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Conserved domains on  [gi|259165937|gb|EEW50491|]
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hypothetical protein HMPREF0290_0939 [Corynebacterium efficiens YS-314]

Protein Classification

DUF3152 domain-containing protein( domain architecture ID 10568353)

DUF3152 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF3152 pfam11350
Protein of unknown function (DUF3152); Some members in this family of proteins are annotated ...
82-286 8.11e-146

Protein of unknown function (DUF3152); Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.


:

Pssm-ID: 431834  Cd Length: 206  Bit Score: 407.63  E-value: 8.11e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259165937   82 LPPGGPFTQEGEGSFRVVGNPLPPVGEG-RVYTYIIEVENGIDTAAYGGDDGFVSVVDATLANPKGWIANPDYAFQHVRP 160
Cdd:pfam11350   1 LPPGGPFTEKGAGTFRVVPGTSPRVGKGtKVFTYTIEVENGLDTAAYGGDDAFAAMVDATLANPKSWTHDPQFAFERVDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259165937  161 DEDPDLRIQLSSLATTHALCGNDIEMETSCFYSDGNRVLINESRWIRGALPFDGDLGSYRQYLINHEVGHGLGYAAHDHC 240
Cdd:pfam11350  81 GKDPDFRIQLVSPQTTRELCGNDIPMETSCFYPDGDRVVINEARWVRGALPFEGDLGSYRQYLINHEVGHGIGYAAHEPC 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 259165937  241 AADGELAPIMMQQTLSLNNSELYRIDPDEVYPDDGATCVYNPWPYP 286
Cdd:pfam11350 161 DKDGELAPIMMQQTFSLSNNELAKIDPDEVYPDDGATCRFNPWPYP 206
 
Name Accession Description Interval E-value
DUF3152 pfam11350
Protein of unknown function (DUF3152); Some members in this family of proteins are annotated ...
82-286 8.11e-146

Protein of unknown function (DUF3152); Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.


Pssm-ID: 431834  Cd Length: 206  Bit Score: 407.63  E-value: 8.11e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259165937   82 LPPGGPFTQEGEGSFRVVGNPLPPVGEG-RVYTYIIEVENGIDTAAYGGDDGFVSVVDATLANPKGWIANPDYAFQHVRP 160
Cdd:pfam11350   1 LPPGGPFTEKGAGTFRVVPGTSPRVGKGtKVFTYTIEVENGLDTAAYGGDDAFAAMVDATLANPKSWTHDPQFAFERVDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259165937  161 DEDPDLRIQLSSLATTHALCGNDIEMETSCFYSDGNRVLINESRWIRGALPFDGDLGSYRQYLINHEVGHGLGYAAHDHC 240
Cdd:pfam11350  81 GKDPDFRIQLVSPQTTRELCGNDIPMETSCFYPDGDRVVINEARWVRGALPFEGDLGSYRQYLINHEVGHGIGYAAHEPC 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 259165937  241 AADGELAPIMMQQTLSLNNSELYRIDPDEVYPDDGATCVYNPWPYP 286
Cdd:pfam11350 161 DKDGELAPIMMQQTFSLSNNELAKIDPDEVYPDDGATCRFNPWPYP 206
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
148-284 3.92e-03

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 37.40  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259165937 148 IANPDyaFQHVRPDEDPDLRIQLSSLA--TTHALCGNDIEMETSCFYSDGnrvlinesrWI-RGALPFDGDLGSYRQYLI 224
Cdd:cd04277   49 VADID--FVEVSDNSGADIRFGNSSDPdgNTAGYAYYPGSGSGTAYGGDI---------WFnSSYDTNSDSPGSYGYQTI 117
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 259165937 225 NHEVGHGLGYaAHDHCAADGELAPImmqqTLSLNNSEL----YRidpDEVYPDDGATCVYNPWP 284
Cdd:cd04277  118 IHEIGHALGL-EHPGDYNGGDPVPP----TYALDSREYtvmsYN---SGYGNGASAGGGYPQTP 173
 
Name Accession Description Interval E-value
DUF3152 pfam11350
Protein of unknown function (DUF3152); Some members in this family of proteins are annotated ...
82-286 8.11e-146

Protein of unknown function (DUF3152); Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.


Pssm-ID: 431834  Cd Length: 206  Bit Score: 407.63  E-value: 8.11e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259165937   82 LPPGGPFTQEGEGSFRVVGNPLPPVGEG-RVYTYIIEVENGIDTAAYGGDDGFVSVVDATLANPKGWIANPDYAFQHVRP 160
Cdd:pfam11350   1 LPPGGPFTEKGAGTFRVVPGTSPRVGKGtKVFTYTIEVENGLDTAAYGGDDAFAAMVDATLANPKSWTHDPQFAFERVDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259165937  161 DEDPDLRIQLSSLATTHALCGNDIEMETSCFYSDGNRVLINESRWIRGALPFDGDLGSYRQYLINHEVGHGLGYAAHDHC 240
Cdd:pfam11350  81 GKDPDFRIQLVSPQTTRELCGNDIPMETSCFYPDGDRVVINEARWVRGALPFEGDLGSYRQYLINHEVGHGIGYAAHEPC 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 259165937  241 AADGELAPIMMQQTLSLNNSELYRIDPDEVYPDDGATCVYNPWPYP 286
Cdd:pfam11350 161 DKDGELAPIMMQQTFSLSNNELAKIDPDEVYPDDGATCRFNPWPYP 206
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
148-284 3.92e-03

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 37.40  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259165937 148 IANPDyaFQHVRPDEDPDLRIQLSSLA--TTHALCGNDIEMETSCFYSDGnrvlinesrWI-RGALPFDGDLGSYRQYLI 224
Cdd:cd04277   49 VADID--FVEVSDNSGADIRFGNSSDPdgNTAGYAYYPGSGSGTAYGGDI---------WFnSSYDTNSDSPGSYGYQTI 117
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 259165937 225 NHEVGHGLGYaAHDHCAADGELAPImmqqTLSLNNSEL----YRidpDEVYPDDGATCVYNPWP 284
Cdd:cd04277  118 IHEIGHALGL-EHPGDYNGGDPVPP----TYALDSREYtvmsYN---SGYGNGASAGGGYPQTP 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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