NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|258676425|gb|ACV87209|]
View 

epididymis secretory protein Li 307, partial [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-261 5.40e-18

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 5.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  10 AWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 89
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  90 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRV 163
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAT--GKLLRtltghsGSVRSVAFSPDGRLLASGSADGTVRL 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425 164 FSAyikevdekpaSTpwgskmpfGQLMSEFGGSGtgGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLP 243
Cdd:COG2319  273 WDL----------AT--------GELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                        250
                 ....*....|....*...
gi 258676425 244 LLSVSFVSENSVVAAGHD 261
Cdd:COG2319  333 VRSVAFSPDGKTLASGSD 350
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-261 5.40e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 5.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  10 AWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 89
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  90 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRV 163
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAT--GKLLRtltghsGSVRSVAFSPDGRLLASGSADGTVRL 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425 164 FSAyikevdekpaSTpwgskmpfGQLMSEFGGSGtgGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLP 243
Cdd:COG2319  273 WDL----------AT--------GELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                        250
                 ....*....|....*...
gi 258676425 244 LLSVSFVSENSVVAAGHD 261
Cdd:COG2319  333 VRSVAFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-271 1.96e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.83  E-value: 1.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  41 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRInrAATFVKWSPLENKFAVGSGARLISVcyf 120
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425 121 esendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFSayikevdekpastpwgskMPFGQLMSEFg 194
Cdd:cd00200   78 -----WDLET--GECVRtltghtSYVSSVAFSPDGRILSSSSRDKTIKVWD------------------VETGKCLTTL- 131

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 258676425 195 gSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFV-SENSVVAAGHDCCPMLFNYDD 271
Cdd:cd00200  132 -RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLST 208
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-75 1.05e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.05e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 258676425    41 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 75
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
37-75 6.32e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 6.32e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 258676425   37 WVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 75
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-261 5.40e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 5.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  10 AWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 89
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  90 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRV 163
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAT--GKLLRtltghsGSVRSVAFSPDGRLLASGSADGTVRL 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425 164 FSAyikevdekpaSTpwgskmpfGQLMSEFGGSGtgGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLP 243
Cdd:COG2319  273 WDL----------AT--------GELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                        250
                 ....*....|....*...
gi 258676425 244 LLSVSFVSENSVVAAGHD 261
Cdd:COG2319  333 VRSVAFSPDGKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
4-259 2.71e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.57  E-value: 2.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425   4 EPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKP 83
Cdd:COG2319  163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KL 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  84 TLVILRINRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVS----KHIKKPIRSTVLSLDWHPNNVLLAAGSCDF 159
Cdd:COG2319  239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL--------WDLAtgelLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425 160 KCRVFSAyikevdekpaSTpwgskmpfGQLMSEFggSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKT 239
Cdd:COG2319  311 TVRLWDL----------AT--------GKLLRTL--TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG 370

                        250       260
                 ....*....|....*....|
gi 258676425 240 EFLPLLSVSFVSENSVVAAG 259
Cdd:COG2319  371 HTGAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-271 1.96e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.83  E-value: 1.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  41 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRInrAATFVKWSPLENKFAVGSGARLISVcyf 120
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425 121 esendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFSayikevdekpastpwgskMPFGQLMSEFg 194
Cdd:cd00200   78 -----WDLET--GECVRtltghtSYVSSVAFSPDGRILSSSSRDKTIKVWD------------------VETGKCLTTL- 131

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 258676425 195 gSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFV-SENSVVAAGHDCCPMLFNYDD 271
Cdd:cd00200  132 -RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
10-261 2.82e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 2.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  10 AWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 89
Cdd:COG2319   85 AFSPDGRLLASASADGTVRLWDLATGLLL--RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG--KLLRTLTG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  90 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIRS------TVLSLDWHPNNVLLAAGSCDFKCRV 163
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRL--------WDLAT--GKLLRTltghtgAVRSVAFSPDGKLLASGSADGTVRL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425 164 FSayikevdekpASTpwgskmpfGQLMSEFGGSgtGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLP 243
Cdd:COG2319  231 WD----------LAT--------GKLLRTLTGH--SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290

                        250
                 ....*....|....*...
gi 258676425 244 LLSVSFVSENSVVAAGHD 261
Cdd:COG2319  291 VNSVAFSPDGKLLASGSD 308
WD40 COG2319
WD40 repeat [General function prediction only];
10-229 7.49e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 7.49e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  10 AWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVilR 89
Cdd:COG2319  211 AFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--G 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  90 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIRS------TVLSLDWHPNNVLLAAGSCDFKCRV 163
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRL--------WDLAT--GKLLRTltghtgAVRSVAFSPDGKTLASGSDDGTVRL 356

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258676425 164 FSAyikevdekpastpwgskmPFGQLMSEFggSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADAS 229
Cdd:COG2319  357 WDL------------------ATGELLRTL--TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-263 6.36e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 6.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425   5 PITCHAWNRDRTQIALSPNNHEVHIYKKNGSQwvKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPT 84
Cdd:cd00200   53 PVRDVAASADGTYLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  85 LVILRINRAATFVKWSPlENKFAVGSGA-RLISVCYFESEndwwvskhikKPIR------STVLSLDWHPNNVLLAAGSC 157
Cdd:cd00200  129 TTLRGHTDWVNSVAFSP-DGTFVASSSQdGTIKLWDLRTG----------KCVAtltghtGEVNSVAFSPDGEKLLSSSS 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425 158 DFKCRVFSayikevdekpastpwgskMPFGQLMSEFGGSgtGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTL 237
Cdd:cd00200  198 DGTIKLWD------------------LSTGKCLGTLRGH--ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257

                        250       260
                 ....*....|....*....|....*..
gi 258676425 238 KTEFLPLLSVSFVSENSVVAAG-HDCC 263
Cdd:cd00200  258 SGHTNSVTSLAWSPDGKRLASGsADGT 284
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-165 5.08e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 5.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425   5 PITCHAWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPT 84
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  85 LVilRINRAATFVKWSPLENKFAVGSGARLISVcyfesendW-WVSKHIKKPIR---STVLSLDWHPNNVLLAAGSCDFK 160
Cdd:cd00200  215 LR--GHENGVNSVAFSPDGYLLASGSEDGTIRV--------WdLRTGECVQTLSghtNSVTSLAWSPDGKRLASGSADGT 284


                 ....*
gi 258676425 161 CRVFS 165
Cdd:cd00200  285 IRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-225 1.05e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425   4 EPITCHAWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKP 83
Cdd:cd00200   94 SYVSSVAFSPDGRILSSSSRDKTIKVW--DVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG--KC 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  84 TLVILRINRAATFVKWSPLENKFAVGSGARLI---------SVCYFESENDWwvskhikkpirstVLSLDWHPNNVLLAA 154
Cdd:cd00200  170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIklwdlstgkCLGTLRGHENG-------------VNSVAFSPDGYLLAS 236

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 258676425 155 GSCDFKCRVFSAYIkevdekpastpwgskmpfGQLMSEFggSGTGGWVHGVSFSASGSRLAWVSHDSTVSV 225
Cdd:cd00200  237 GSEDGTIRVWDLRT------------------GECVQTL--SGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
54-261 5.98e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 5.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425  54 DWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRinRAATFVKWSPLENKFAVGSGARLISVcyfeSENDWWVSKHIK 133
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLA--AAVASLAASPDGARLAAGAGDLTLLL----LDAAAGALLATL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258676425 134 KPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAyikeVDEKPASTPWGskmpfgqlmsefggsgTGGWVHGVSFSASGSR 213
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDL----ATGLLLRTLTG----------------HTGAVRSVAFSPDGKT 134

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 258676425 214 LAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHD 261
Cdd:COG2319  135 LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-75 1.05e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.05e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 258676425    41 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 75
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
37-75 6.32e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 6.32e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 258676425   37 WVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 75
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH