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Conserved domains on  [gi|258570887|ref|XP_002544247|]
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uncharacterized protein UREG_03764 [Uncinocarpus reesii 1704]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 10510134)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins

Gene Ontology:  GO:1902936|GO:0008289
PubMed:  12767229|17428729

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
143-323 1.73e-25

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


:

Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 101.64  E-value: 1.73e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887 143 YPQWTGRRDRRGIPVYVFVIKHLNSKNMaayssgaastatssthasstVSPKLLR-LFALYENMTRfvvplssslprpNP 221
Cdd:cd00170   10 GIGYLGGRDKEGRPVLVFRAGWDPPKLL--------------------DLEELLRyLVYLLEKALR------------EL 57
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887 222 ETPISSTTNIVDISGVGLKQFWNLKgHMQDASVLATAHYPETLDRIFIIGAPSFFPTVWGWIKRWFDPVTTSKIFILSAS 301
Cdd:cd00170   58 EEQVEGFVVIIDLKGFSLSNLSDLS-LLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSD 136
                        170       180
                 ....*....|....*....|..
gi 258570887 302 evKSTLTSFMDPSSFPKQYGGE 323
Cdd:cd00170  137 --LEELLEYIDPDQLPKELGGT 156
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
64-113 1.46e-11

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


:

Pssm-ID: 461043  Cd Length: 53  Bit Score: 59.21  E-value: 1.46e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 258570887   64 ALEEFKAICTEKELYRPAEEG--KTASHDDATLLRYLRARKFEVKGALDQFQ 113
Cdd:pfam03765   1 AYDELLELLKDEDEETDREKFwlTREDHDDVCLLRFLRARKWDVEKAIKMLE 52
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
143-323 1.73e-25

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 101.64  E-value: 1.73e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887 143 YPQWTGRRDRRGIPVYVFVIKHLNSKNMaayssgaastatssthasstVSPKLLR-LFALYENMTRfvvplssslprpNP 221
Cdd:cd00170   10 GIGYLGGRDKEGRPVLVFRAGWDPPKLL--------------------DLEELLRyLVYLLEKALR------------EL 57
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887 222 ETPISSTTNIVDISGVGLKQFWNLKgHMQDASVLATAHYPETLDRIFIIGAPSFFPTVWGWIKRWFDPVTTSKIFILSAS 301
Cdd:cd00170   58 EEQVEGFVVIIDLKGFSLSNLSDLS-LLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSD 136
                        170       180
                 ....*....|....*....|..
gi 258570887 302 evKSTLTSFMDPSSFPKQYGGE 323
Cdd:cd00170  137 --LEELLEYIDPDQLPKELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
150-322 1.95e-23

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 95.79  E-value: 1.95e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887  150 RDRRGIPVYVFVIKHLNSKnmaayssgaastatssthasSTVSPKLLRLFAL-YENMTRFVvplssslprpnPETPISST 228
Cdd:pfam00650   9 RDKEGRPVLYLRLGRHDPK--------------------KSSEEELVRFLVLvLERALLLM-----------PEGQVEGL 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887  229 TNIVDISGVGLKQF-WNLKGHMQDASVLATAHYPETLDRIFIIGAPSFFPTVWGWIKRWFDPVTTSKIFILSASEVKsTL 307
Cdd:pfam00650  58 TVIIDLKGLSLSNMdWWSISLLKKIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEE-EL 136
                         170
                  ....*....|....*
gi 258570887  308 TSFMDPSSFPKQYGG 322
Cdd:pfam00650 137 EKYIPPEQLPKEYGG 151
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
137-325 1.15e-19

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 85.43  E-value: 1.15e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887   137 EEARRVYPQWTGRrDRRGIPVYVFVIKHLNSKNMAayssgaastatssthasstvSPKLLR-LFALYENMtrfvvplsss 215
Cdd:smart00516   3 ELLKAYIPGGRGY-DKDGRPVLIERAGRFDLKSVT--------------------LEELLRyLVYVLEKI---------- 51
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887   216 LPRPNPETPISSTTNIVDISGVGLKQFwnlkghmqDASVLATA------HYPETLDRIFIIGAPSFFPTVWGWIKRWFDP 289
Cdd:smart00516  52 LQEEKKTGGIEGFTVIFDLKGLSMSNP--------DLSVLRKIlkilqdHYPERLGKVYIINPPWFFRVLWKIIKPFLDE 123
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 258570887   290 VTTSKIFILSaSEVKSTLTSFMDPSSFPKQYGGELE 325
Cdd:smart00516 124 KTREKIRFVG-NDSKEELLEYIDKEQLPEELGGTLD 158
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
64-113 1.46e-11

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 59.21  E-value: 1.46e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 258570887   64 ALEEFKAICTEKELYRPAEEG--KTASHDDATLLRYLRARKFEVKGALDQFQ 113
Cdd:pfam03765   1 AYDELLELLKDEDEETDREKFwlTREDHDDVCLLRFLRARKWDVEKAIKMLE 52
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
62-113 4.51e-08

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 49.09  E-value: 4.51e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 258570887    62 ERALEEFKAICTEKELYRPAEegktasHDDATLLRYLRARKFEVKGALDQFQ 113
Cdd:smart01100   1 EEALEELRELLEKHPDLLPPR------LDDAFLLRFLRARKFDVEKAKEMLE 46
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
143-323 1.73e-25

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 101.64  E-value: 1.73e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887 143 YPQWTGRRDRRGIPVYVFVIKHLNSKNMaayssgaastatssthasstVSPKLLR-LFALYENMTRfvvplssslprpNP 221
Cdd:cd00170   10 GIGYLGGRDKEGRPVLVFRAGWDPPKLL--------------------DLEELLRyLVYLLEKALR------------EL 57
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887 222 ETPISSTTNIVDISGVGLKQFWNLKgHMQDASVLATAHYPETLDRIFIIGAPSFFPTVWGWIKRWFDPVTTSKIFILSAS 301
Cdd:cd00170   58 EEQVEGFVVIIDLKGFSLSNLSDLS-LLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSD 136
                        170       180
                 ....*....|....*....|..
gi 258570887 302 evKSTLTSFMDPSSFPKQYGGE 323
Cdd:cd00170  137 --LEELLEYIDPDQLPKELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
150-322 1.95e-23

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 95.79  E-value: 1.95e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887  150 RDRRGIPVYVFVIKHLNSKnmaayssgaastatssthasSTVSPKLLRLFAL-YENMTRFVvplssslprpnPETPISST 228
Cdd:pfam00650   9 RDKEGRPVLYLRLGRHDPK--------------------KSSEEELVRFLVLvLERALLLM-----------PEGQVEGL 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887  229 TNIVDISGVGLKQF-WNLKGHMQDASVLATAHYPETLDRIFIIGAPSFFPTVWGWIKRWFDPVTTSKIFILSASEVKsTL 307
Cdd:pfam00650  58 TVIIDLKGLSLSNMdWWSISLLKKIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEE-EL 136
                         170
                  ....*....|....*
gi 258570887  308 TSFMDPSSFPKQYGG 322
Cdd:pfam00650 137 EKYIPPEQLPKEYGG 151
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
137-325 1.15e-19

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 85.43  E-value: 1.15e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887   137 EEARRVYPQWTGRrDRRGIPVYVFVIKHLNSKNMAayssgaastatssthasstvSPKLLR-LFALYENMtrfvvplsss 215
Cdd:smart00516   3 ELLKAYIPGGRGY-DKDGRPVLIERAGRFDLKSVT--------------------LEELLRyLVYVLEKI---------- 51
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258570887   216 LPRPNPETPISSTTNIVDISGVGLKQFwnlkghmqDASVLATA------HYPETLDRIFIIGAPSFFPTVWGWIKRWFDP 289
Cdd:smart00516  52 LQEEKKTGGIEGFTVIFDLKGLSMSNP--------DLSVLRKIlkilqdHYPERLGKVYIINPPWFFRVLWKIIKPFLDE 123
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 258570887   290 VTTSKIFILSaSEVKSTLTSFMDPSSFPKQYGGELE 325
Cdd:smart00516 124 KTREKIRFVG-NDSKEELLEYIDKEQLPEELGGTLD 158
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
64-113 1.46e-11

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 59.21  E-value: 1.46e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 258570887   64 ALEEFKAICTEKELYRPAEEG--KTASHDDATLLRYLRARKFEVKGALDQFQ 113
Cdd:pfam03765   1 AYDELLELLKDEDEETDREKFwlTREDHDDVCLLRFLRARKWDVEKAIKMLE 52
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
62-113 4.51e-08

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 49.09  E-value: 4.51e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 258570887    62 ERALEEFKAICTEKELYRPAEegktasHDDATLLRYLRARKFEVKGALDQFQ 113
Cdd:smart01100   1 EEALEELRELLEKHPDLLPPR------LDDAFLLRFLRARKFDVEKAKEMLE 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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