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Conserved domains on  [gi|25742698|ref|NP_612550|]
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epithelial cell adhesion molecule precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EpCAM_N pfam18635
Epithelial cell adhesion molecule N-terminal domain; EpCAM (epithelial cell adhesion molecule), ...
 29-61 1.29e-15

Epithelial cell adhesion molecule N-terminal domain; EpCAM (epithelial cell adhesion molecule), a stem and carcinoma cell marker, is a cell surface protein involved in homotypic cell-cell adhesion via intercellular oligomerization and proliferative signalling via proteolytic cleavage. Structure analysis indicate that it is composed of three domains: N-domain, Thyroglobulin type-1A (TY) domain and the C-terminal domain. This entry represents the small and compact disulphide-rich N-terminal domain of 39 amino-acid residues.


:

Pssm-ID: 465828  Cd Length: 33  Bit Score: 69.44  E-value: 1.29e-15
                          10        20        30
                  ....*....|....*....|....*....|...
gi 25742698    29 CNNYKLTSRCYENENGECQCTSYGTQNTVICSK 61
Cdd:pfam18635   1 CENYKLTTNCSLNNNGQCQCTSYGTQNTVICSK 33
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 66-131 1.10e-13

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 65.02  E-value: 1.10e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25742698    66 CLVMKAEMTHSKSGRRmkpegaiqNNDGLYDPECDEQGLFKAKQCNG-TATCWCVNTAGVRRTDKDT 131
Cdd:pfam00086   1 CERERARALEQAASGR--------PASGLYIPNCDEDGFYKPVQCHGsTGYCWCVDPEGQEIPGTRT 59
 
Name Accession Description Interval E-value
EpCAM_N pfam18635
Epithelial cell adhesion molecule N-terminal domain; EpCAM (epithelial cell adhesion molecule), ...
 29-61 1.29e-15

Epithelial cell adhesion molecule N-terminal domain; EpCAM (epithelial cell adhesion molecule), a stem and carcinoma cell marker, is a cell surface protein involved in homotypic cell-cell adhesion via intercellular oligomerization and proliferative signalling via proteolytic cleavage. Structure analysis indicate that it is composed of three domains: N-domain, Thyroglobulin type-1A (TY) domain and the C-terminal domain. This entry represents the small and compact disulphide-rich N-terminal domain of 39 amino-acid residues.


Pssm-ID: 465828  Cd Length: 33  Bit Score: 69.44  E-value: 1.29e-15
                          10        20        30
                  ....*....|....*....|....*....|...
gi 25742698    29 CNNYKLTSRCYENENGECQCTSYGTQNTVICSK 61
Cdd:pfam18635   1 CENYKLTTNCSLNNNGQCQCTSYGTQNTVICSK 33
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 66-131 1.10e-13

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 65.02  E-value: 1.10e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25742698    66 CLVMKAEMTHSKSGRRmkpegaiqNNDGLYDPECDEQGLFKAKQCNG-TATCWCVNTAGVRRTDKDT 131
Cdd:pfam00086   1 CERERARALEQAASGR--------PASGLYIPNCDEDGFYKPVQCHGsTGYCWCVDPEGQEIPGTRT 59
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 65-125 1.71e-13

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 64.41  E-value: 1.71e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25742698  65 KCLVMKAEMTHSKSGRRmkpegaiqnNDGLYDPECDEQGLFKAKQCNG-TATCWCVNTAGVR 125
Cdd:cd00191   1 PCERERASALESLAGPK---------LSGLYVPQCDEDGNYEPVQCHGsTGYCWCVDPDGEE 53
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 97-125 1.06e-06

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 44.68  E-value: 1.06e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 25742698     97 PECDEQGLFKAKQCNG-TATCWCVNTAGVR 125
Cdd:smart00211   2 PQCDEDGNYEPVQCDGsSGQCWCVDATGRE 31
 
Name Accession Description Interval E-value
EpCAM_N pfam18635
Epithelial cell adhesion molecule N-terminal domain; EpCAM (epithelial cell adhesion molecule), ...
 29-61 1.29e-15

Epithelial cell adhesion molecule N-terminal domain; EpCAM (epithelial cell adhesion molecule), a stem and carcinoma cell marker, is a cell surface protein involved in homotypic cell-cell adhesion via intercellular oligomerization and proliferative signalling via proteolytic cleavage. Structure analysis indicate that it is composed of three domains: N-domain, Thyroglobulin type-1A (TY) domain and the C-terminal domain. This entry represents the small and compact disulphide-rich N-terminal domain of 39 amino-acid residues.


Pssm-ID: 465828  Cd Length: 33  Bit Score: 69.44  E-value: 1.29e-15
                          10        20        30
                  ....*....|....*....|....*....|...
gi 25742698    29 CNNYKLTSRCYENENGECQCTSYGTQNTVICSK 61
Cdd:pfam18635   1 CENYKLTTNCSLNNNGQCQCTSYGTQNTVICSK 33
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 66-131 1.10e-13

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 65.02  E-value: 1.10e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25742698    66 CLVMKAEMTHSKSGRRmkpegaiqNNDGLYDPECDEQGLFKAKQCNG-TATCWCVNTAGVRRTDKDT 131
Cdd:pfam00086   1 CERERARALEQAASGR--------PASGLYIPNCDEDGFYKPVQCHGsTGYCWCVDPEGQEIPGTRT 59
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 65-125 1.71e-13

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 64.41  E-value: 1.71e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25742698  65 KCLVMKAEMTHSKSGRRmkpegaiqnNDGLYDPECDEQGLFKAKQCNG-TATCWCVNTAGVR 125
Cdd:cd00191   1 PCERERASALESLAGPK---------LSGLYVPQCDEDGNYEPVQCHGsTGYCWCVDPDGEE 53
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 97-125 1.06e-06

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 44.68  E-value: 1.06e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 25742698     97 PECDEQGLFKAKQCNG-TATCWCVNTAGVR 125
Cdd:smart00211   2 PQCDEDGNYEPVQCDGsSGQCWCVDATGRE 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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