NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|257153465|ref|NP_001158012|]
View 

disrupted in schizophrenia 1 protein isoform d [Homo sapiens]

Protein Classification

GumC domain-containing protein( domain architecture ID 1004375)

GumC domain-containing protein similar to Homo sapiens C-type lectin domain family 4 member M (CLEC4M), also known as DC-SIGNR (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin-Related), which is a type of C-type lectin receptor (CLR) that is primarily involved in the recognition and binding of specific carbohydrate structures on the surface of pathogens

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GumC super family cl34566
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
347-540 1.92e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3206:

Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.01  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153465 347 QMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQL---PSRQPALSSFLGHLAAQVQAALRRGATQH 423
Cdd:COG3206  188 RKELEEAEAALEEFRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELaeaEARLAALRAQLGSGPDALPELLQSPVIQQ 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153465 424 LQERIKSLNLSLKEittkvcMSEKFCS------TLRKKVNDIETQLPALLEAKMHAISGNhfwtAKDLTEEIRSLTSERE 497
Cdd:COG3206  268 LRAQLAELEAELAE------LSARYTPnhpdviALRAQIAALRAQLQQEAQRILASLEAE----LEALQAREASLQAQLA 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 257153465 498 GLEgllskllvlssRNVKKLGSVKEDYNRLRREVEHQETAYET 540
Cdd:COG3206  338 QLE-----------ARLAELPELEAELRRLEREVEVARELYES 369
 
Name Accession Description Interval E-value
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
347-540 1.92e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.01  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153465 347 QMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQL---PSRQPALSSFLGHLAAQVQAALRRGATQH 423
Cdd:COG3206  188 RKELEEAEAALEEFRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELaeaEARLAALRAQLGSGPDALPELLQSPVIQQ 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153465 424 LQERIKSLNLSLKEittkvcMSEKFCS------TLRKKVNDIETQLPALLEAKMHAISGNhfwtAKDLTEEIRSLTSERE 497
Cdd:COG3206  268 LRAQLAELEAELAE------LSARYTPnhpdviALRAQIAALRAQLQQEAQRILASLEAE----LEALQAREASLQAQLA 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 257153465 498 GLEgllskllvlssRNVKKLGSVKEDYNRLRREVEHQETAYET 540
Cdd:COG3206  338 QLE-----------ARLAELPELEAELRRLEREVEVARELYES 369
 
Name Accession Description Interval E-value
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
347-540 1.92e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.01  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153465 347 QMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQL---PSRQPALSSFLGHLAAQVQAALRRGATQH 423
Cdd:COG3206  188 RKELEEAEAALEEFRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELaeaEARLAALRAQLGSGPDALPELLQSPVIQQ 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153465 424 LQERIKSLNLSLKEittkvcMSEKFCS------TLRKKVNDIETQLPALLEAKMHAISGNhfwtAKDLTEEIRSLTSERE 497
Cdd:COG3206  268 LRAQLAELEAELAE------LSARYTPnhpdviALRAQIAALRAQLQQEAQRILASLEAE----LEALQAREASLQAQLA 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 257153465 498 GLEgllskllvlssRNVKKLGSVKEDYNRLRREVEHQETAYET 540
Cdd:COG3206  338 QLE-----------ARLAELPELEAELRRLEREVEVARELYES 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH