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pyruvate dehydrogenase complex dehydrogenase (E1) component [uncultured bacterium HF130_AEPn_2]
Protein Classification
AceE family protein ( domain architecture ID 11457666 )
AceE family protein
List of domain hits
Name
Accession
Description
Interval
E-value
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
1-886
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1850.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 1 M NANNAVRL -- D D DPQET R EWLES IES V LST EG RP RA H YL IDQ LL DFDVARHGDFHGRV TTPY V NTI A V DRQL PYPG NLA 78
Cdd:COG2609 1 M SMDGLPSQ lp D I DPQET Q EWLES LDA V IEE EG PE RA R YL LER LL ERARRSGVGLPFSA TTPY I NTI P V EQEP PYPG DEE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 79 I ERR LNAF IRWNAMAMV L RA GK - HS G V GGHI ATY ASAA V LY D VGF D HFFRG RTETFA GDLVY I QGH S SPGIY G RA Y LEGR 157
Cdd:COG2609 81 L ERR IRSI IRWNAMAMV V RA NR k GG G L GGHI SSF ASAA T LY E VGF N HFFRG PDHPGG GDLVY F QGH A SPGIY A RA F LEGR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 158 ID E A QLDNFR R E AG G Q GLSSYPHP R LMPDFWQFPTVSMGLGPI T A A YQARFM R YL DL R S LK PEAG RKVWAFLGDGEMD Q P 237
Cdd:COG2609 161 LT E E QLDNFR Q E VD G K GLSSYPHP W LMPDFWQFPTVSMGLGPI N A I YQARFM K YL HN R G LK DTSD RKVWAFLGDGEMD E P 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 238 ESL A AISLA G REKLDNLIFV V NCNLQRLDGPVRGN A K V IQE F E SLY R A AGWNVIKVIWG GG WD A LLAKD RS G L L RQ RM M E 317
Cdd:COG2609 241 ESL G AISLA A REKLDNLIFV I NCNLQRLDGPVRGN G K I IQE L E GVF R G AGWNVIKVIWG SE WD P LLAKD TD G A L VK RM N E 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 318 C VDGDYQ N YK SQN GAYVREHFFGKYPEL L ALV E D L SD D DIW K L S RGGHDP D KVY N AY A AAV R H T GQPTVILAKT V KG F GM 397
Cdd:COG2609 321 T VDGDYQ T YK AKD GAYVREHFFGKYPEL K ALV A D M SD E DIW R L N RGGHDP R KVY A AY K AAV E H K GQPTVILAKT I KG Y GM 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 398 GEAGEG Q NI N HQ L KK MGAEAV KAFRDRF GLEVA D D QL A E I PY L KP TA DS E E GR Y FAA RR Q ALGGY I P A R HSSVPA L Q VP P 477
Cdd:COG2609 401 GEAGEG R NI T HQ Q KK LDLDDL KAFRDRF NIPIS D E QL E E L PY Y KP AE DS P E MK Y LHE RR K ALGGY L P Q R RTKAEP L E VP E 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 478 L E AFA TQ LK DT G E R A ISTTMAFVRIL GT LLKD PH IGK L IVPIVPDE S RTFGME S LFRQIGI H S A VGQLYTP Q DA G QL S YY 557
Cdd:COG2609 481 L S AFA AL LK GS G K R E ISTTMAFVRIL ND LLKD KE IGK R IVPIVPDE A RTFGME G LFRQIGI Y S P VGQLYTP V DA D QL L YY 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 558 KESKDGQILQEG L NE S GA F SSWIAA S TSY AN HG LMTL PFYI F YSMFGFQRVGDLAWAAGD A RARGFL L GATAGRTTL M GE 637
Cdd:COG2609 561 KESKDGQILQEG I NE A GA M SSWIAA G TSY ST HG VPMI PFYI Y YSMFGFQRVGDLAWAAGD Q RARGFL I GATAGRTTL N GE 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 638 GLQH D DGHSH V LAS VV P C CVSYDP T FAYELAVI IRE G M RRMY V EQE DIY YYIT LL NENY PH PAMPEGVE D GILKGMY R LK 717
Cdd:COG2609 641 GLQH Q DGHSH L LAS TI P N CVSYDP A FAYELAVI VQD G L RRMY G EQE NVF YYIT VM NENY AQ PAMPEGVE E GILKGMY L LK 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 718 A G --- QQAQ VQL M GSG S ILREV I AAA D LL R ED FA V DS DVWSVTS LT ELRR E GL G VERWNLLHPE D EPR TS YV E QCLA DHP 794
Cdd:COG2609 721 E G egk GKPR VQL L GSG T ILREV L AAA E LL A ED WG V AA DVWSVTS FN ELRR D GL D VERWNLLHPE E EPR VP YV T QCLA GAE 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 795 GPVV I ATDYM KIFA DQIRP F V T g R R FVA LGTDGFG Q SDTREALR E FFEVDR HF IV L A T LKALAD D G L I SRTK V G EAI SR Y 874
Cdd:COG2609 801 GPVV A ATDYM RAVP DQIRP W V P - G R YTV LGTDGFG R SDTREALR R FFEVDR YS IV V A A LKALAD E G K I DASV V A EAI KK Y 879
890
....*....|..
gi 256556960 875 GID V DK AD P AGV 886
Cdd:COG2609 880 GID P DK PN P LTA 891
Name
Accession
Description
Interval
E-value
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
1-886
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1850.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 1 M NANNAVRL -- D D DPQET R EWLES IES V LST EG RP RA H YL IDQ LL DFDVARHGDFHGRV TTPY V NTI A V DRQL PYPG NLA 78
Cdd:COG2609 1 M SMDGLPSQ lp D I DPQET Q EWLES LDA V IEE EG PE RA R YL LER LL ERARRSGVGLPFSA TTPY I NTI P V EQEP PYPG DEE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 79 I ERR LNAF IRWNAMAMV L RA GK - HS G V GGHI ATY ASAA V LY D VGF D HFFRG RTETFA GDLVY I QGH S SPGIY G RA Y LEGR 157
Cdd:COG2609 81 L ERR IRSI IRWNAMAMV V RA NR k GG G L GGHI SSF ASAA T LY E VGF N HFFRG PDHPGG GDLVY F QGH A SPGIY A RA F LEGR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 158 ID E A QLDNFR R E AG G Q GLSSYPHP R LMPDFWQFPTVSMGLGPI T A A YQARFM R YL DL R S LK PEAG RKVWAFLGDGEMD Q P 237
Cdd:COG2609 161 LT E E QLDNFR Q E VD G K GLSSYPHP W LMPDFWQFPTVSMGLGPI N A I YQARFM K YL HN R G LK DTSD RKVWAFLGDGEMD E P 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 238 ESL A AISLA G REKLDNLIFV V NCNLQRLDGPVRGN A K V IQE F E SLY R A AGWNVIKVIWG GG WD A LLAKD RS G L L RQ RM M E 317
Cdd:COG2609 241 ESL G AISLA A REKLDNLIFV I NCNLQRLDGPVRGN G K I IQE L E GVF R G AGWNVIKVIWG SE WD P LLAKD TD G A L VK RM N E 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 318 C VDGDYQ N YK SQN GAYVREHFFGKYPEL L ALV E D L SD D DIW K L S RGGHDP D KVY N AY A AAV R H T GQPTVILAKT V KG F GM 397
Cdd:COG2609 321 T VDGDYQ T YK AKD GAYVREHFFGKYPEL K ALV A D M SD E DIW R L N RGGHDP R KVY A AY K AAV E H K GQPTVILAKT I KG Y GM 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 398 GEAGEG Q NI N HQ L KK MGAEAV KAFRDRF GLEVA D D QL A E I PY L KP TA DS E E GR Y FAA RR Q ALGGY I P A R HSSVPA L Q VP P 477
Cdd:COG2609 401 GEAGEG R NI T HQ Q KK LDLDDL KAFRDRF NIPIS D E QL E E L PY Y KP AE DS P E MK Y LHE RR K ALGGY L P Q R RTKAEP L E VP E 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 478 L E AFA TQ LK DT G E R A ISTTMAFVRIL GT LLKD PH IGK L IVPIVPDE S RTFGME S LFRQIGI H S A VGQLYTP Q DA G QL S YY 557
Cdd:COG2609 481 L S AFA AL LK GS G K R E ISTTMAFVRIL ND LLKD KE IGK R IVPIVPDE A RTFGME G LFRQIGI Y S P VGQLYTP V DA D QL L YY 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 558 KESKDGQILQEG L NE S GA F SSWIAA S TSY AN HG LMTL PFYI F YSMFGFQRVGDLAWAAGD A RARGFL L GATAGRTTL M GE 637
Cdd:COG2609 561 KESKDGQILQEG I NE A GA M SSWIAA G TSY ST HG VPMI PFYI Y YSMFGFQRVGDLAWAAGD Q RARGFL I GATAGRTTL N GE 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 638 GLQH D DGHSH V LAS VV P C CVSYDP T FAYELAVI IRE G M RRMY V EQE DIY YYIT LL NENY PH PAMPEGVE D GILKGMY R LK 717
Cdd:COG2609 641 GLQH Q DGHSH L LAS TI P N CVSYDP A FAYELAVI VQD G L RRMY G EQE NVF YYIT VM NENY AQ PAMPEGVE E GILKGMY L LK 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 718 A G --- QQAQ VQL M GSG S ILREV I AAA D LL R ED FA V DS DVWSVTS LT ELRR E GL G VERWNLLHPE D EPR TS YV E QCLA DHP 794
Cdd:COG2609 721 E G egk GKPR VQL L GSG T ILREV L AAA E LL A ED WG V AA DVWSVTS FN ELRR D GL D VERWNLLHPE E EPR VP YV T QCLA GAE 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 795 GPVV I ATDYM KIFA DQIRP F V T g R R FVA LGTDGFG Q SDTREALR E FFEVDR HF IV L A T LKALAD D G L I SRTK V G EAI SR Y 874
Cdd:COG2609 801 GPVV A ATDYM RAVP DQIRP W V P - G R YTV LGTDGFG R SDTREALR R FFEVDR YS IV V A A LKALAD E G K I DASV V A EAI KK Y 879
890
....*....|..
gi 256556960 875 GID V DK AD P AGV 886
Cdd:COG2609 880 GID P DK PN P LTA 891
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
10-886
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1788.55
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 10 D D DP Q ET R EWLE SIE SV LST EG RP RAHYL ID QLL DFDVARHGDFHGRV TTPY V NTI A V DRQLP YPG N L AI ERR LNAF IRW 89
Cdd:PRK09405 11 D I DP I ET Q EWLE ALD SV IRE EG PE RAHYL LE QLL ERAREKGVSLPASA TTPY I NTI P V EEEPE YPG D L EL ERR IRSY IRW 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 90 NA M AMVLRA G K HS - G V GGHI ATY AS A A V LY D VGF D HFFR GRT E TFA GDLV YI QGH S SPGIY G RA Y LEGR ID E A QLDNFR R 168
Cdd:PRK09405 91 NA A AMVLRA N K KD l G L GGHI SSF AS S A T LY E VGF N HFFR APN E PHG GDLV FF QGH A SPGIY A RA F LEGR LT E E QLDNFR Q 170
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 169 E AG G Q GLSSYPHP R LMPDFWQFPTVSMGLGPI T A A YQARF MR YL DL R S LK PEAGR KVWAFLGDGEMD Q PESL A AISLA G R 248
Cdd:PRK09405 171 E VD G K GLSSYPHP W LMPDFWQFPTVSMGLGPI M A I YQARF LK YL EN R G LK DTSDQ KVWAFLGDGEMD E PESL G AISLA A R 250
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 249 EKLDNLIFV V NCNLQRLDGPVRGN A K V IQE F E SLY R A AGWNVIKVIWG GG WD A LLAKD R SG L L R Q R M M E C VDGDYQ N YK S 328
Cdd:PRK09405 251 EKLDNLIFV I NCNLQRLDGPVRGN G K I IQE L E GIF R G AGWNVIKVIWG SR WD P LLAKD T SG K L V Q L M N E T VDGDYQ T YK A 330
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 329 QN GAYVREHFFGKYPE LL ALV E D L SDDDIW K L S RGGHDP D KVY N AY A AAV R H T GQPTVILAKT V KG F GMGEAGEG Q NI N H 408
Cdd:PRK09405 331 KD GAYVREHFFGKYPE TK ALV A D M SDDDIW A L N RGGHDP R KVY A AY K AAV E H K GQPTVILAKT I KG Y GMGEAGEG K NI A H 410
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 409 Q L KK MGAEAV K A FRDRF GLEVA D D QL AEI PY L KP TA DS E E GR Y FAA RR Q ALGGY I PAR HSSVPA L Q VP P L E AF ATQ LK DT 488
Cdd:PRK09405 411 Q V KK LDLDDL K H FRDRF NIPIS D E QL EKL PY Y KP GE DS P E IK Y LHE RR K ALGGY L PAR RPKFEP L E VP A L S AF EAL LK GS 490
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 489 GER A ISTTMAFVRIL GT LLKD PH IGK L IVPI V PDE S RTFGME S LFRQIGI HSAV GQLYTP Q D AG QL S YYKESKDGQILQE 568
Cdd:PRK09405 491 GER E ISTTMAFVRIL NI LLKD KE IGK R IVPI I PDE A RTFGME G LFRQIGI YNPH GQLYTP V D RD QL M YYKESKDGQILQE 570
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 569 G L NE S GA FS SWIAA S TSY AN HG LMTL PFYI F YSMFGFQR V GDLAWAAGD A RARGFLLG A TAGRTTL M GEGLQH D DGHSH V 648
Cdd:PRK09405 571 G I NE A GA MA SWIAA A TSY ST HG EPMI PFYI Y YSMFGFQR I GDLAWAAGD Q RARGFLLG G TAGRTTL N GEGLQH E DGHSH I 650
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 649 LAS VV P C CVSYDP T FAYE L AVI IRE G M RRMY V EQE DIY YYIT LL NENY PH PAMPEG V E D GILKGMY R L KAGQ ---- QAQ V 724
Cdd:PRK09405 651 LAS TI P N CVSYDP A FAYE V AVI VQD G L RRMY G EQE NVF YYIT VM NENY HQ PAMPEG A E E GILKGMY K L ETAE gkkg KPK V 730
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 725 QL M GSG S ILREV IA AA DL L R ED FA V DS DVWSVTS LT EL R R E G LG VERWN L LHP ED EPR TS YV E Q C L ADHP GPVV I ATDYM 804
Cdd:PRK09405 731 QL L GSG T ILREV LE AA EI L A ED YG V AA DVWSVTS FN EL A R D G QD VERWN M LHP TE EPR VP YV T Q V L KGAE GPVV A ATDYM 810
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 805 K I FA D QIR P FV T g RRF V A LGTDGFG Q SDTREALR E FFEVD RHFI V L A T LKALAD D G L I SRTK V G EAI SR YGID V DKA D P A 884
Cdd:PRK09405 811 K L FA E QIR A FV P - GDY V V LGTDGFG R SDTREALR R FFEVD AEYV V V A A LKALAD E G E I DASV V A EAI KK YGID P DKA N P R 889
..
gi 256556960 885 GV 886
Cdd:PRK09405 890 TA 891
aceE
TIGR00759 pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
10-883
0e+00
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain]
Cd Length: 885
Bit Score: 1416.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 10 D D DP Q ET R EWLES IE SVL ST EG RP RA H YL ID QLL D fdvar HGDF HG ----- RV TT P Y V NTI A V DR Q LP YPG N L AI ERR LN 84
Cdd:TIGR00759 5 D V DP I ET Q EWLES LD SVL AE EG PA RA R YL LE QLL E ----- YARE HG vpipa GT TT D Y I NTI P V EE Q PA YPG D L EL ERR IR 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 85 AF IRWNA M AMVLRA G - K HS G V GGHI A TYASAA V LY D VGF D HFFRG RT E TFA GDLV YI QGH SS PGIY G RA Y LEGR ID E A QL 163
Cdd:TIGR00759 80 SI IRWNA I AMVLRA N k K DL G L GGHI S TYASAA T LY E VGF N HFFRG HS E GGG GDLV FF QGH AA PGIY A RA F LEGR LT E E QL 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 164 DNFR R E AG G Q GLSSYPHP R LMPDFWQFPTVSMGLGPI T A A YQARFM R YL DL R S LK PEAGR KVWAFLGDGEMD Q PES LA AI 243
Cdd:TIGR00759 160 DNFR Q E VQ G D GLSSYPHP W LMPDFWQFPTVSMGLGPI N A I YQARFM K YL EN R G LK DTGDQ KVWAFLGDGEMD E PES KG AI 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 244 SL A G REKLDNL I FV V NCNLQRLDGPVRGN A K V IQE F ESL Y R A AGWNVIKV I WG GG WDALLA K D R SG L L RQR M M E C VDGDY 323
Cdd:TIGR00759 240 TF A A REKLDNL T FV I NCNLQRLDGPVRGN G K I IQE L ESL F R G AGWNVIKV L WG SE WDALLA R D T SG V L VKL M N E T VDGDY 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 324 Q N YK SQN GAYVREHFF GKY PEL L ALV E D L SD D DIW K L S RGGHDP D KVY N AYAAA VR H T GQPTVILAKT V KG F GMG E A G E G 403
Cdd:TIGR00759 320 Q T YK AKD GAYVREHFF NRT PEL K ALV A D M SD A DIW A L N RGGHDP R KVY A AYAAA QE H K GQPTVILAKT I KG Y GMG D A A E S 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 404 Q N IN HQ L KK MGAE A V K A FRDRF G L EVA D D Q LA E I PY LK P TAD S E E G RY FA ARRQALGGY I PAR HSSVPA L Q VP P LE A F AT 483
Cdd:TIGR00759 400 R N TA HQ V KK LEVD A L K N FRDRF E L PLS D A Q VE E L PY YH P GEG S P E V RY LL ARRQALGGY L PAR RTFAEH L T VP A LE F F GA 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 484 Q LK DT GER AI STTMAFVRIL GT LLKD PH IGK L IVPIVPDE S RTFGME S LFRQIGI H S AV GQ L YTP Q DA GQ L SY YKESKDG 563
Cdd:TIGR00759 480 L LK GS GER EV STTMAFVRIL NK LLKD KE IGK R IVPIVPDE A RTFGME G LFRQIGI Y S PH GQ T YTP V DA DS L LA YKESKDG 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 564 QILQEG L NE S GA FS SWIAA S TSYA N HG LMTL PFYI F YSMFGFQR V GDL A WAA G D A RARGFLLGATAGRTTL M GEGLQH D D 643
Cdd:TIGR00759 560 QILQEG I NE A GA MA SWIAA A TSYA T HG EPMI PFYI Y YSMFGFQR I GDL C WAA A D Q RARGFLLGATAGRTTL N GEGLQH E D 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 644 GHS HVL A SVV P C C VS YDP T FAYE L AVI IRE G M RRMY V EQED IY YY I T LL NENY PH P A MPEG V E D GILKG M YR LKAGQ --- 720
Cdd:TIGR00759 640 GHS LLQ A ATI P N C IA YDP A FAYE V AVI MED G L RRMY G EQED VF YY V T VM NENY VQ P P MPEG A E E GILKG L YR FETST eek 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 721 - QAQ VQL M GSG S I L R E VI A AA D LL RE D FA V D SDVWSVTS L TEL R R E G LG VERWNLLHP EDE PR T SYV E Q C L ADHPG PV VI 799
Cdd:TIGR00759 720 a KGH VQL L GSG A I M R A VI E AA Q LL AA D WG V A SDVWSVTS F TEL A R D G HD VERWNLLHP TET PR V SYV A Q V L NEADA PV IA 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 800 A TDY MKI FA D QIRP F V T g R RF V A LGTDGFG Q SDTRE A LR E FFEVD RHFI VLA T L K ALADDG L I SRTK V GE AI SR YGID V D 879
Cdd:TIGR00759 800 S TDY VRA FA E QIRP Y V P - R KY V T LGTDGFG R SDTRE N LR H FFEVD AKSV VLA A L Y ALADDG E I DGDV V AD AI AK YGID P D 878
....
gi 256556960 880 KA D P 883
Cdd:TIGR00759 879 KA N P 882
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
77-461
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 689.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 77 L A IERR LNAF IRWNAMAMV L RA G K HS - G V GGHIAT Y ASAA V LY D VGF D HFFR G R T E TFA GDLVY I QGH S SPGIY G RA Y LE 155
Cdd:cd02017 1 L E IERR IRSL IRWNAMAMV H RA N K KD l G I GGHIAT F ASAA T LY E VGF N HFFR A R G E GGG GDLVY F QGH A SPGIY A RA F LE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 156 GR ID E A QLDNFR R E A GG Q GLSSYPHP R LMPDFW Q FPTVSMGLGPI T A A YQARF M RYL DL R S LK PEAGR KVWAFLGDGEMD 235
Cdd:cd02017 81 GR LT E E QLDNFR Q E V GG G GLSSYPHP W LMPDFW E FPTVSMGLGPI Q A I YQARF N RYL ED R G LK DTSDQ KVWAFLGDGEMD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 236 Q PESL A AI S LA G REKLDNLIFVVNCNLQRLDGPVRGN A K V IQE F E SLY R A AGWNVIKVIWG GG WD A LLAKD RS G L LRQRM 315
Cdd:cd02017 161 E PESL G AI G LA A REKLDNLIFVVNCNLQRLDGPVRGN G K I IQE L E GIF R G AGWNVIKVIWG SK WD E LLAKD GG G A LRQRM 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 316 M E C VDGDYQ NY K SQN GAYVREHFFGKYPEL L ALV E DLSD D D I W K L S RGGHDP D KVY N AY AA AV R H T G Q PTVILAKT V KG F 395
Cdd:cd02017 241 E E T VDGDYQ TL K AKD GAYVREHFFGKYPEL K ALV T DLSD E D L W A L N RGGHDP R KVY A AY KK AV E H K G K PTVILAKT I KG Y 320
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 256556960 396 G M G E AGEG Q N IN HQ L KKM GAEAV KA F RDRFG LE V A D D QL A E I PY L KP TAD SEE GR Y FAA RR Q ALGG 461
Cdd:cd02017 321 G L G A AGEG R N HA HQ V KKM TEDEL KA L RDRFG IP V S D E QL E E G PY Y KP PEG SEE IK Y LHE RR H ALGG 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
473-699
5.43e-106
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 326.69
E-value: 5.43e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 473 L QV P P L E -- A FA T Q LKDTGE R A ISTTMAFVRIL GT L L KD PH IGK LI VPI V PDE S RTFGME SL FRQ I GI HSAV GQ L Y T P Q D 550
Cdd:pfam17831 1 L EI P D L D dk I FA S Q TGGSKG R E ISTTMAFVRIL NG L V KD KK IGK QV VPI I PDE A RTFGME GM FRQ L GI YTSE GQ K Y E P V D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 551 A GQ LSY Y K E S K D GQIL Q EG LN E S GA F S S WIAA S TSY A NH GLMT LPFY IF YSMFGFQR V GDLAWAAGD AR ARGFL L G A TAG 630
Cdd:pfam17831 81 K GQ IMF Y R E D K Q GQIL E EG IS E A GA M S A WIAA A TSY S NH NTTL LPFY VY YSMFGFQR I GDLAWAAGD MQ ARGFL V G G TAG 160
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256556960 631 RTTL M GEGLQH D DGHSH VL AS VV P C C V SYDPT F A Y E L AVI IRE G MR RM YVEQ E DIY YY I T LL NENY P HP 699
Cdd:pfam17831 161 RTTL N GEGLQH Q DGHSH IQ AS TI P N C R SYDPT Y A H E V AVI VQD G LK RM FADK E NCF YY L T VM NENY E HP 229
Name
Accession
Description
Interval
E-value
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
1-886
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1850.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 1 M NANNAVRL -- D D DPQET R EWLES IES V LST EG RP RA H YL IDQ LL DFDVARHGDFHGRV TTPY V NTI A V DRQL PYPG NLA 78
Cdd:COG2609 1 M SMDGLPSQ lp D I DPQET Q EWLES LDA V IEE EG PE RA R YL LER LL ERARRSGVGLPFSA TTPY I NTI P V EQEP PYPG DEE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 79 I ERR LNAF IRWNAMAMV L RA GK - HS G V GGHI ATY ASAA V LY D VGF D HFFRG RTETFA GDLVY I QGH S SPGIY G RA Y LEGR 157
Cdd:COG2609 81 L ERR IRSI IRWNAMAMV V RA NR k GG G L GGHI SSF ASAA T LY E VGF N HFFRG PDHPGG GDLVY F QGH A SPGIY A RA F LEGR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 158 ID E A QLDNFR R E AG G Q GLSSYPHP R LMPDFWQFPTVSMGLGPI T A A YQARFM R YL DL R S LK PEAG RKVWAFLGDGEMD Q P 237
Cdd:COG2609 161 LT E E QLDNFR Q E VD G K GLSSYPHP W LMPDFWQFPTVSMGLGPI N A I YQARFM K YL HN R G LK DTSD RKVWAFLGDGEMD E P 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 238 ESL A AISLA G REKLDNLIFV V NCNLQRLDGPVRGN A K V IQE F E SLY R A AGWNVIKVIWG GG WD A LLAKD RS G L L RQ RM M E 317
Cdd:COG2609 241 ESL G AISLA A REKLDNLIFV I NCNLQRLDGPVRGN G K I IQE L E GVF R G AGWNVIKVIWG SE WD P LLAKD TD G A L VK RM N E 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 318 C VDGDYQ N YK SQN GAYVREHFFGKYPEL L ALV E D L SD D DIW K L S RGGHDP D KVY N AY A AAV R H T GQPTVILAKT V KG F GM 397
Cdd:COG2609 321 T VDGDYQ T YK AKD GAYVREHFFGKYPEL K ALV A D M SD E DIW R L N RGGHDP R KVY A AY K AAV E H K GQPTVILAKT I KG Y GM 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 398 GEAGEG Q NI N HQ L KK MGAEAV KAFRDRF GLEVA D D QL A E I PY L KP TA DS E E GR Y FAA RR Q ALGGY I P A R HSSVPA L Q VP P 477
Cdd:COG2609 401 GEAGEG R NI T HQ Q KK LDLDDL KAFRDRF NIPIS D E QL E E L PY Y KP AE DS P E MK Y LHE RR K ALGGY L P Q R RTKAEP L E VP E 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 478 L E AFA TQ LK DT G E R A ISTTMAFVRIL GT LLKD PH IGK L IVPIVPDE S RTFGME S LFRQIGI H S A VGQLYTP Q DA G QL S YY 557
Cdd:COG2609 481 L S AFA AL LK GS G K R E ISTTMAFVRIL ND LLKD KE IGK R IVPIVPDE A RTFGME G LFRQIGI Y S P VGQLYTP V DA D QL L YY 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 558 KESKDGQILQEG L NE S GA F SSWIAA S TSY AN HG LMTL PFYI F YSMFGFQRVGDLAWAAGD A RARGFL L GATAGRTTL M GE 637
Cdd:COG2609 561 KESKDGQILQEG I NE A GA M SSWIAA G TSY ST HG VPMI PFYI Y YSMFGFQRVGDLAWAAGD Q RARGFL I GATAGRTTL N GE 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 638 GLQH D DGHSH V LAS VV P C CVSYDP T FAYELAVI IRE G M RRMY V EQE DIY YYIT LL NENY PH PAMPEGVE D GILKGMY R LK 717
Cdd:COG2609 641 GLQH Q DGHSH L LAS TI P N CVSYDP A FAYELAVI VQD G L RRMY G EQE NVF YYIT VM NENY AQ PAMPEGVE E GILKGMY L LK 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 718 A G --- QQAQ VQL M GSG S ILREV I AAA D LL R ED FA V DS DVWSVTS LT ELRR E GL G VERWNLLHPE D EPR TS YV E QCLA DHP 794
Cdd:COG2609 721 E G egk GKPR VQL L GSG T ILREV L AAA E LL A ED WG V AA DVWSVTS FN ELRR D GL D VERWNLLHPE E EPR VP YV T QCLA GAE 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 795 GPVV I ATDYM KIFA DQIRP F V T g R R FVA LGTDGFG Q SDTREALR E FFEVDR HF IV L A T LKALAD D G L I SRTK V G EAI SR Y 874
Cdd:COG2609 801 GPVV A ATDYM RAVP DQIRP W V P - G R YTV LGTDGFG R SDTREALR R FFEVDR YS IV V A A LKALAD E G K I DASV V A EAI KK Y 879
890
....*....|..
gi 256556960 875 GID V DK AD P AGV 886
Cdd:COG2609 880 GID P DK PN P LTA 891
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
10-886
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1788.55
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 10 D D DP Q ET R EWLE SIE SV LST EG RP RAHYL ID QLL DFDVARHGDFHGRV TTPY V NTI A V DRQLP YPG N L AI ERR LNAF IRW 89
Cdd:PRK09405 11 D I DP I ET Q EWLE ALD SV IRE EG PE RAHYL LE QLL ERAREKGVSLPASA TTPY I NTI P V EEEPE YPG D L EL ERR IRSY IRW 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 90 NA M AMVLRA G K HS - G V GGHI ATY AS A A V LY D VGF D HFFR GRT E TFA GDLV YI QGH S SPGIY G RA Y LEGR ID E A QLDNFR R 168
Cdd:PRK09405 91 NA A AMVLRA N K KD l G L GGHI SSF AS S A T LY E VGF N HFFR APN E PHG GDLV FF QGH A SPGIY A RA F LEGR LT E E QLDNFR Q 170
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 169 E AG G Q GLSSYPHP R LMPDFWQFPTVSMGLGPI T A A YQARF MR YL DL R S LK PEAGR KVWAFLGDGEMD Q PESL A AISLA G R 248
Cdd:PRK09405 171 E VD G K GLSSYPHP W LMPDFWQFPTVSMGLGPI M A I YQARF LK YL EN R G LK DTSDQ KVWAFLGDGEMD E PESL G AISLA A R 250
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 249 EKLDNLIFV V NCNLQRLDGPVRGN A K V IQE F E SLY R A AGWNVIKVIWG GG WD A LLAKD R SG L L R Q R M M E C VDGDYQ N YK S 328
Cdd:PRK09405 251 EKLDNLIFV I NCNLQRLDGPVRGN G K I IQE L E GIF R G AGWNVIKVIWG SR WD P LLAKD T SG K L V Q L M N E T VDGDYQ T YK A 330
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 329 QN GAYVREHFFGKYPE LL ALV E D L SDDDIW K L S RGGHDP D KVY N AY A AAV R H T GQPTVILAKT V KG F GMGEAGEG Q NI N H 408
Cdd:PRK09405 331 KD GAYVREHFFGKYPE TK ALV A D M SDDDIW A L N RGGHDP R KVY A AY K AAV E H K GQPTVILAKT I KG Y GMGEAGEG K NI A H 410
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 409 Q L KK MGAEAV K A FRDRF GLEVA D D QL AEI PY L KP TA DS E E GR Y FAA RR Q ALGGY I PAR HSSVPA L Q VP P L E AF ATQ LK DT 488
Cdd:PRK09405 411 Q V KK LDLDDL K H FRDRF NIPIS D E QL EKL PY Y KP GE DS P E IK Y LHE RR K ALGGY L PAR RPKFEP L E VP A L S AF EAL LK GS 490
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 489 GER A ISTTMAFVRIL GT LLKD PH IGK L IVPI V PDE S RTFGME S LFRQIGI HSAV GQLYTP Q D AG QL S YYKESKDGQILQE 568
Cdd:PRK09405 491 GER E ISTTMAFVRIL NI LLKD KE IGK R IVPI I PDE A RTFGME G LFRQIGI YNPH GQLYTP V D RD QL M YYKESKDGQILQE 570
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 569 G L NE S GA FS SWIAA S TSY AN HG LMTL PFYI F YSMFGFQR V GDLAWAAGD A RARGFLLG A TAGRTTL M GEGLQH D DGHSH V 648
Cdd:PRK09405 571 G I NE A GA MA SWIAA A TSY ST HG EPMI PFYI Y YSMFGFQR I GDLAWAAGD Q RARGFLLG G TAGRTTL N GEGLQH E DGHSH I 650
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 649 LAS VV P C CVSYDP T FAYE L AVI IRE G M RRMY V EQE DIY YYIT LL NENY PH PAMPEG V E D GILKGMY R L KAGQ ---- QAQ V 724
Cdd:PRK09405 651 LAS TI P N CVSYDP A FAYE V AVI VQD G L RRMY G EQE NVF YYIT VM NENY HQ PAMPEG A E E GILKGMY K L ETAE gkkg KPK V 730
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 725 QL M GSG S ILREV IA AA DL L R ED FA V DS DVWSVTS LT EL R R E G LG VERWN L LHP ED EPR TS YV E Q C L ADHP GPVV I ATDYM 804
Cdd:PRK09405 731 QL L GSG T ILREV LE AA EI L A ED YG V AA DVWSVTS FN EL A R D G QD VERWN M LHP TE EPR VP YV T Q V L KGAE GPVV A ATDYM 810
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 805 K I FA D QIR P FV T g RRF V A LGTDGFG Q SDTREALR E FFEVD RHFI V L A T LKALAD D G L I SRTK V G EAI SR YGID V DKA D P A 884
Cdd:PRK09405 811 K L FA E QIR A FV P - GDY V V LGTDGFG R SDTREALR R FFEVD AEYV V V A A LKALAD E G E I DASV V A EAI KK YGID P DKA N P R 889
..
gi 256556960 885 GV 886
Cdd:PRK09405 890 TA 891
PRK13012
PRK13012 2-oxoacid dehydrogenase subunit E1; Provisional
1-886
0e+00
2-oxoacid dehydrogenase subunit E1; Provisional
Pssm-ID: 237267 [Multi-domain]
Cd Length: 896
Bit Score: 1730.94
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 1 MN A NN A VRL D D DPQET R EWLE SIES V LSTE G RP RA H YL I D Q LL DFDV AR HGDFH G RV TTPYVNTI A VD R Q L PYPG N LA I E 80
Cdd:PRK13012 10 LL A AA A QLP D I DPQET A EWLE ALDA V VAHA G PE RA R YL L D R LL ERAA AR GIALP G LL TTPYVNTI P VD Q Q P PYPG D LA L E 89
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 81 R RL N A F IRWNA M AMV L RA GK - HSGV GGHIA T YASAA V L YD VGF D HFFRGR TETFA GDLVY I Q G HS S PGIY G RA Y LEGR ID 159
Cdd:PRK13012 90 E RL A A I IRWNA L AMV V RA NR a YGEL GGHIA S YASAA D L FE VGF N HFFRGR DDAGG GDLVY F Q P HS A PGIY A RA F LEGR LS 169
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 160 E A QLD N FR R E A GG Q GLSSYPHP R LMPDFWQFPT V SMG L GPI T A A YQARFMRYL DL R S LK PEA GRKVW A F L GDGEMD Q PES 239
Cdd:PRK13012 170 E E QLD H FR Q E I GG P GLSSYPHP W LMPDFWQFPT G SMG I GPI N A I YQARFMRYL QH R G LK DTS GRKVW G F F GDGEMD E PES 249
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 240 L AA I SLA G RE K LDNL I FV V NCNLQRLDGPVRGN AKV IQE F E S L Y R A AGWNVIKV I WG GG WDAL L A K D RS G L L RQ R MM E C V 319
Cdd:PRK13012 250 I AA L SLA A RE G LDNL V FV I NCNLQRLDGPVRGN GRI IQE L E A L F R G AGWNVIKV L WG SD WDAL F A R D TT G A L VR R FA E T V 329
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 320 DG DY Q NY K SQN GAY V REHFFG KY PEL L ALV ED LSD D DI WK L S RGGHDP D KVY N AYAAAVRH T GQPTVILAKT V KG F GMGE 399
Cdd:PRK13012 330 DG QF Q TF K AND GAY N REHFFG QD PEL A ALV AH LSD E DI DR L K RGGHDP R KVY A AYAAAVRH K GQPTVILAKT K KG Y GMGE 409
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 400 AGEG QNIN HQ L KK MGA EA V KAFRDRF G L EVA D D QL AEI P YL KP TA DS E E G RY FA ARR Q ALGGY I P A R HSSV P A L Q VPPL E 479
Cdd:PRK13012 410 AGEG RMTT HQ Q KK LDV EA L KAFRDRF R L PLS D E QL EQL P FY KP AE DS P E M RY LH ARR A ALGGY L P R R RTAA P P L P VPPL S 489
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 480 AFA TQLKDT G ERAI STTMAFVR I LG T LLKD PHI G KL IVPIV P DE S RTFGM ES LFRQ I GI H S AV GQLY T P Q DAG Q L S YY K E 559
Cdd:PRK13012 490 AFA QFALGA G GKEM STTMAFVR M LG N LLKD KAL G PR IVPIV A DE A RTFGM AN LFRQ V GI Y S PL GQLY E P E DAG S L L YY R E 569
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 560 S KDGQIL Q EG LN E S GA F SSWIAA S TSY AN HGL MT LPFYI F YSMFGFQRVGDL A WAA G D A RARGFLLGATAGRTTL M GEGL 639
Cdd:PRK13012 570 A KDGQIL E EG IT E A GA I SSWIAA A TSY SV HGL PM LPFYI Y YSMFGFQRVGDL I WAA A D Q RARGFLLGATAGRTTL G GEGL 649
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 640 QH D DGHSH V LAS VV P C C VS YDP T FAYELAVI IRE GMRRM YV EQED IY YY I T LL NENY PH PA M PEG V E D GILKGMYRL K A - 718
Cdd:PRK13012 650 QH Q DGHSH L LAS TI P N C RA YDP A FAYELAVI VDD GMRRM LE EQED VF YY L T VM NENY AQ PA L PEG A E E GILKGMYRL A A a 729
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 719 GQQAQ VQL M GSG S ILREV I AAA D LL RE D FA VD S DVWSVTS L TELRR E GL GV ER W NLL H P ED E P R TS YV E QCLA DHP GPVV 798
Cdd:PRK13012 730 AEAPR VQL L GSG A ILREV L AAA R LL AD D WG VD A DVWSVTS F TELRR D GL AA ER A NLL G P AE E A R VP YV T QCLA GTR GPVV 809
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 799 I ATDY MKIFAD QIR P FV T g R R F V A LGTDGFG Q SDTR E ALR E FFEVDRH F IVLA T LKALADDG LIS RT K V G EAI S RYGID V 878
Cdd:PRK13012 810 A ATDY VRAVPE QIR A FV P - A R Y V T LGTDGFG R SDTR A ALR R FFEVDRH S IVLA A LKALADDG EVE RT V V A EAI E RYGID D 888
....*...
gi 256556960 879 DK AD P AG V 886
Cdd:PRK13012 889 DK TP P WE V 896
aceE
TIGR00759 pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
10-883
0e+00
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain]
Cd Length: 885
Bit Score: 1416.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 10 D D DP Q ET R EWLES IE SVL ST EG RP RA H YL ID QLL D fdvar HGDF HG ----- RV TT P Y V NTI A V DR Q LP YPG N L AI ERR LN 84
Cdd:TIGR00759 5 D V DP I ET Q EWLES LD SVL AE EG PA RA R YL LE QLL E ----- YARE HG vpipa GT TT D Y I NTI P V EE Q PA YPG D L EL ERR IR 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 85 AF IRWNA M AMVLRA G - K HS G V GGHI A TYASAA V LY D VGF D HFFRG RT E TFA GDLV YI QGH SS PGIY G RA Y LEGR ID E A QL 163
Cdd:TIGR00759 80 SI IRWNA I AMVLRA N k K DL G L GGHI S TYASAA T LY E VGF N HFFRG HS E GGG GDLV FF QGH AA PGIY A RA F LEGR LT E E QL 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 164 DNFR R E AG G Q GLSSYPHP R LMPDFWQFPTVSMGLGPI T A A YQARFM R YL DL R S LK PEAGR KVWAFLGDGEMD Q PES LA AI 243
Cdd:TIGR00759 160 DNFR Q E VQ G D GLSSYPHP W LMPDFWQFPTVSMGLGPI N A I YQARFM K YL EN R G LK DTGDQ KVWAFLGDGEMD E PES KG AI 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 244 SL A G REKLDNL I FV V NCNLQRLDGPVRGN A K V IQE F ESL Y R A AGWNVIKV I WG GG WDALLA K D R SG L L RQR M M E C VDGDY 323
Cdd:TIGR00759 240 TF A A REKLDNL T FV I NCNLQRLDGPVRGN G K I IQE L ESL F R G AGWNVIKV L WG SE WDALLA R D T SG V L VKL M N E T VDGDY 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 324 Q N YK SQN GAYVREHFF GKY PEL L ALV E D L SD D DIW K L S RGGHDP D KVY N AYAAA VR H T GQPTVILAKT V KG F GMG E A G E G 403
Cdd:TIGR00759 320 Q T YK AKD GAYVREHFF NRT PEL K ALV A D M SD A DIW A L N RGGHDP R KVY A AYAAA QE H K GQPTVILAKT I KG Y GMG D A A E S 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 404 Q N IN HQ L KK MGAE A V K A FRDRF G L EVA D D Q LA E I PY LK P TAD S E E G RY FA ARRQALGGY I PAR HSSVPA L Q VP P LE A F AT 483
Cdd:TIGR00759 400 R N TA HQ V KK LEVD A L K N FRDRF E L PLS D A Q VE E L PY YH P GEG S P E V RY LL ARRQALGGY L PAR RTFAEH L T VP A LE F F GA 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 484 Q LK DT GER AI STTMAFVRIL GT LLKD PH IGK L IVPIVPDE S RTFGME S LFRQIGI H S AV GQ L YTP Q DA GQ L SY YKESKDG 563
Cdd:TIGR00759 480 L LK GS GER EV STTMAFVRIL NK LLKD KE IGK R IVPIVPDE A RTFGME G LFRQIGI Y S PH GQ T YTP V DA DS L LA YKESKDG 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 564 QILQEG L NE S GA FS SWIAA S TSYA N HG LMTL PFYI F YSMFGFQR V GDL A WAA G D A RARGFLLGATAGRTTL M GEGLQH D D 643
Cdd:TIGR00759 560 QILQEG I NE A GA MA SWIAA A TSYA T HG EPMI PFYI Y YSMFGFQR I GDL C WAA A D Q RARGFLLGATAGRTTL N GEGLQH E D 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 644 GHS HVL A SVV P C C VS YDP T FAYE L AVI IRE G M RRMY V EQED IY YY I T LL NENY PH P A MPEG V E D GILKG M YR LKAGQ --- 720
Cdd:TIGR00759 640 GHS LLQ A ATI P N C IA YDP A FAYE V AVI MED G L RRMY G EQED VF YY V T VM NENY VQ P P MPEG A E E GILKG L YR FETST eek 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 721 - QAQ VQL M GSG S I L R E VI A AA D LL RE D FA V D SDVWSVTS L TEL R R E G LG VERWNLLHP EDE PR T SYV E Q C L ADHPG PV VI 799
Cdd:TIGR00759 720 a KGH VQL L GSG A I M R A VI E AA Q LL AA D WG V A SDVWSVTS F TEL A R D G HD VERWNLLHP TET PR V SYV A Q V L NEADA PV IA 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 800 A TDY MKI FA D QIRP F V T g R RF V A LGTDGFG Q SDTRE A LR E FFEVD RHFI VLA T L K ALADDG L I SRTK V GE AI SR YGID V D 879
Cdd:TIGR00759 800 S TDY VRA FA E QIRP Y V P - R KY V T LGTDGFG R SDTRE N LR H FFEVD AKSV VLA A L Y ALADDG E I DGDV V AD AI AK YGID P D 878
....
gi 256556960 880 KA D P 883
Cdd:TIGR00759 879 KA N P 882
AKGDH_not_PDH
TIGR03186 alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric ...
10-875
0e+00
alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric form of the pyruvate dehydrogenase E1 component (see model TIGR00759), often encoded next to L-methionine gamma-lyase gene (mdeA). The member from a strain of Pseudomonas putida was shown to act on alpha-ketobutyrate, which is produced by MdeA.This model serves as an exception model to TIGR00759, as other proteins hitting TIGR00759 should be identified as the pyruvate dehydrogenase E1 component.
Pssm-ID: 132230 [Multi-domain]
Cd Length: 889
Bit Score: 1159.64
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 10 D D DPQET R EWL ESIES V LSTE G RP RA H YL ID QL LDFDVARHGDFHGRVT TPYVNTIAVD RQL PYPG N L AI E R RL N A FI RW 89
Cdd:TIGR03186 5 D T DPQET A EWL DALDG V VAHA G AE RA Q YL LA QL AAHAARLGLAPPAAGA TPYVNTIAVD QEP PYPG D L QL E E RL A A IL RW 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 90 NA M AMV L RA GK - HSGV GGHIA T YASAA V L YD VGF D HFFR GRTETFA GDLVY I Q G HS S PG I Y G RA Y LEG RIDE AQL DNF R R 168
Cdd:TIGR03186 85 NA L AMV V RA NR a YGEL GGHIA S YASAA D L FE VGF N HFFR AAGDASG GDLVY F Q P HS A PG V Y A RA F LEG FLSD AQL AHY R Q 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 169 E AG G Q GL S SYPHP R LMPDFWQFPT V SMG L GPI T A A YQARFMRYL DL R S L KPEA GRKVW A F L GDGEMD Q PES LA A I SLA G R 248
Cdd:TIGR03186 165 E IA G P GL C SYPHP W LMPDFWQFPT G SMG I GPI N A I YQARFMRYL QN R G L ARTE GRKVW G F F GDGEMD E PES IG A L SLA A R 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 249 E K LDNL I FV V NCNLQRLDGPVRGN AKV I Q E F ES LYRA AGWNVIKV I WG GG WDAL L A K D RS G L L RQRMMEC VDG DY Q NYKS 328
Cdd:TIGR03186 245 E R LDNL V FV I NCNLQRLDGPVRGN GRI I D E L ES QFAG AGWNVIKV L WG SD WDAL F A R D AT G A L ARAFAHT VDG QF Q TFSA 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 329 QN GAY V R EH FFG KY P E L L ALV ED LSD D DI WK L S RGGHD PD K V Y N AY AA AVRH T G Q PTVILAKT V KGFGMG EA G E G QNIN H 408
Cdd:TIGR03186 325 ND GAY N R AR FFG QD P A L A ALV AH LSD E DI DR L R RGGHD AR K L Y A AY DR AVRH E G R PTVILAKT M KGFGMG AI G Q G RMTT H 404
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 409 Q L KK MGA EA VK AFRDRF G L EVA D DQLAEIPYL KP TA DS E E G RY FA ARR Q ALGGY I P A R HSSVP - AL Q VP P L EAFATQLK D 487
Cdd:TIGR03186 405 Q Q KK LDV EA LL AFRDRF R L PLS D ADVEQLKFY KP DE DS A E M RY LH ARR A ALGGY L P R R RTAAT h AL A VP A L PSWGRFAL D 484
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 488 TGERAI STTMA F VR I LG T LLKD PHI G KL IVPIV P DE S RTFGM ES LFRQ I GI H S AV GQ L Y T P Q D A G QLS YY K E SK DGQIL Q 567
Cdd:TIGR03186 485 AEGKEM STTMA I VR M LG A LLKD AEL G PR IVPIV A DE A RTFGM AN LFRQ V GI Y S PL GQ R Y E P E D L G SML YY R E DT DGQIL E 564
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 568 EG LN E S GA F SSWIAA S TSY AN H G L MT LPFYI F YSMFGFQR V GDL A WAA G D A RARGFL L GAT A G R TTL M GEGLQH D DG H SH 647
Cdd:TIGR03186 565 EG IS E A GA I SSWIAA A TSY SV H D L PM LPFYI Y YSMFGFQR I GDL I WAA A D Q RARGFL I GAT S G K TTL G GEGLQH Q DG T SH 644
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 648 VL AS V VP C C VSY DP T FAYE L AVI IR EGMR R M YVE Q E D IY YY I T LL NENY PH P AM PE GVE D ---- GILKGMY R L KAGQQ A - 722
Cdd:TIGR03186 645 LA AS T VP N C RAW DP A FAYE V AVI VD EGMR E M LER Q R D EF YY L T VT NENY AQ P SL PE DRL D avrr GILKGMY P L DPAAL A a 724
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 723 - Q VQL M GSG S IL R EV I AAA D LLR E D FAV D SD VWSVTS L TEL R R E G LGV ER WNL L HPEDE P RTSY V E Q C L ADHP GPV VI AT 801
Cdd:TIGR03186 725 a R VQL L GSG A IL G EV Q AAA R LLR D D WGI D AA VWSVTS F TEL A R D G RAA ER AQR L GDAER P PSPH V A Q A L GATQ GPV IA AT 804
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256556960 802 DY MKIFADQ IR PF V TG r R F V A LGTDGFG Q SDTR E ALR E FFEVDR HF IV L A T L K ALADDGL IS R TK V GE AI S RYG 875
Cdd:TIGR03186 805 DY VRAVPEL IR AY V PR - R Y V T LGTDGFG R SDTR A ALR A FFEVDR AS IV I A A L Q ALADDGL VA R DV V RQ AI A RYG 877
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
77-461
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 689.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 77 L A IERR LNAF IRWNAMAMV L RA G K HS - G V GGHIAT Y ASAA V LY D VGF D HFFR G R T E TFA GDLVY I QGH S SPGIY G RA Y LE 155
Cdd:cd02017 1 L E IERR IRSL IRWNAMAMV H RA N K KD l G I GGHIAT F ASAA T LY E VGF N HFFR A R G E GGG GDLVY F QGH A SPGIY A RA F LE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 156 GR ID E A QLDNFR R E A GG Q GLSSYPHP R LMPDFW Q FPTVSMGLGPI T A A YQARF M RYL DL R S LK PEAGR KVWAFLGDGEMD 235
Cdd:cd02017 81 GR LT E E QLDNFR Q E V GG G GLSSYPHP W LMPDFW E FPTVSMGLGPI Q A I YQARF N RYL ED R G LK DTSDQ KVWAFLGDGEMD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 236 Q PESL A AI S LA G REKLDNLIFVVNCNLQRLDGPVRGN A K V IQE F E SLY R A AGWNVIKVIWG GG WD A LLAKD RS G L LRQRM 315
Cdd:cd02017 161 E PESL G AI G LA A REKLDNLIFVVNCNLQRLDGPVRGN G K I IQE L E GIF R G AGWNVIKVIWG SK WD E LLAKD GG G A LRQRM 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 316 M E C VDGDYQ NY K SQN GAYVREHFFGKYPEL L ALV E DLSD D D I W K L S RGGHDP D KVY N AY AA AV R H T G Q PTVILAKT V KG F 395
Cdd:cd02017 241 E E T VDGDYQ TL K AKD GAYVREHFFGKYPEL K ALV T DLSD E D L W A L N RGGHDP R KVY A AY KK AV E H K G K PTVILAKT I KG Y 320
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 256556960 396 G M G E AGEG Q N IN HQ L KKM GAEAV KA F RDRFG LE V A D D QL A E I PY L KP TAD SEE GR Y FAA RR Q ALGG 461
Cdd:cd02017 321 G L G A AGEG R N HA HQ V KKM TEDEL KA L RDRFG IP V S D E QL E E G PY Y KP PEG SEE IK Y LHE RR H ALGG 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
473-699
5.43e-106
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 326.69
E-value: 5.43e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 473 L QV P P L E -- A FA T Q LKDTGE R A ISTTMAFVRIL GT L L KD PH IGK LI VPI V PDE S RTFGME SL FRQ I GI HSAV GQ L Y T P Q D 550
Cdd:pfam17831 1 L EI P D L D dk I FA S Q TGGSKG R E ISTTMAFVRIL NG L V KD KK IGK QV VPI I PDE A RTFGME GM FRQ L GI YTSE GQ K Y E P V D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 551 A GQ LSY Y K E S K D GQIL Q EG LN E S GA F S S WIAA S TSY A NH GLMT LPFY IF YSMFGFQR V GDLAWAAGD AR ARGFL L G A TAG 630
Cdd:pfam17831 81 K GQ IMF Y R E D K Q GQIL E EG IS E A GA M S A WIAA A TSY S NH NTTL LPFY VY YSMFGFQR I GDLAWAAGD MQ ARGFL V G G TAG 160
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256556960 631 RTTL M GEGLQH D DGHSH VL AS VV P C C V SYDPT F A Y E L AVI IRE G MR RM YVEQ E DIY YY I T LL NENY P HP 699
Cdd:pfam17831 161 RTTL N GEGLQH Q DGHSH IQ AS TI P N C R SYDPT Y A H E V AVI VQD G LK RM FADK E NCF YY L T VM NENY E HP 229
TPP_TK
cd02012 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK ...
87-422
6.98e-24
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.
Pssm-ID: 238970 [Multi-domain]
Cd Length: 255
Bit Score: 101.81
E-value: 6.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 87 IR WNAMA MV LR AG khsgv G GH IATYA SAA VLYD V GFDHFFRGRTE -- TFAGDLVYIQ -- GH S SP GI Y GRAY L E G RID E AQ 162
Cdd:cd02012 3 IR RLSID MV QK AG ----- S GH PGGSL SAA DILA V LYFKVLKYDPA dp KWPNRDRFVL sk GH A SP AL Y AVLA L A G YLP E ED 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 163 L DN FR reagg Q GL S SY P - HP - RLMPDFWQFP T V S M G L G - PITA -- A YQARFMR yldlrslkpe AGRK V WAF LGDGE MDQP 237
Cdd:cd02012 78 L KT FR ----- Q LG S RL P g HP e YGLTPGVEVT T G S L G Q G l SVAV gm A LAEKLLG ---------- FDYR V YVL LGDGE LQEG 142
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 238 ESLA A I S L AG RE KLDNLI FV V NC N LQRL DGP VRGNAKV i QEFESLYR A A GWNVI K V I wgggwdallakdrsgllrqrmme 317
Cdd:cd02012 143 SVWE A A S F AG HY KLDNLI AI V DS N RIQI DGP TDDILFT - EDLAKKFE A F GWNVI E V D ----------------------- 198
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 318 cvdgdyqnyksqngayvrehffgkypellalvedlsdddiwklsrg GHD PDKVYN A YAA A VRHT G Q PT V I L AKT V KG F G M 397
Cdd:cd02012 199 ---------------------------------------------- GHD VEEILA A LEE A KKSK G K PT L I I AKT I KG K G V 232
330 340
....*....|....*....|....*
gi 256556960 398 GEA g E GQNIN H q L K KM G A E A V KAFR 422
Cdd:cd02012 233 PFM - E NTAKW H - G K PL G E E E V ELAK 255
PRK05899
PRK05899 transketolase; Reviewed
76-428
9.37e-19
transketolase; Reviewed
Pssm-ID: 235639 [Multi-domain]
Cd Length: 586
Bit Score: 90.96
E-value: 9.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 76 NLAIERR L NAF IR WNAMAM V LR A G khsgv G GH IATYAS AA VLYD V GFDH F F R --------- G R tetfag D - L V YIQ GH S S 145
Cdd:PRK05899 4 DMELLQL L ANA IR VLSIDA V QK A N ----- S GH PGMPMG AA DIAY V LWTR F L R hdpknpkwp N R ------ D r F V LSA GH G S 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 146 PGI Y GRAY L E G - RIDEAQ L D NFR reagg Q GL S SY P - HP rlmp DFWQF P T V SMGL GP ---- ITA ---- A YQARFMRY L DL R 215
Cdd:PRK05899 73 MLL Y SLLH L A G y DLSIDD L K NFR ----- Q LG S KT P g HP ---- EYGHT P G V ETTT GP lgqg LAN avgm A LAEKYLAA L FN R 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 216 SLKPEAGRKVWAFL GDG EMDQPE S LA A I SLAG RE KL D NLI FVVNC N - LQ r L DGP VR G -- NAK V IQE FE slyr A A GW N VI k 292
Cdd:PRK05899 144 PGLDIVDHYTYVLC GDG DLMEGI S HE A C SLAG HL KL G NLI VIYDD N r IS - I DGP TE G wf TED V KKR FE ---- A Y GW H VI - 217
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 293 viwgggwdallakdrsgllrqrmme C VD gdyqnyksqngayvrehffgkypellalvedlsdddiwklsrg GHD PDKVYN 372
Cdd:PRK05899 218 ------------------------- E VD ------------------------------------------- GHD VEAIDA 229
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 256556960 373 A YAA A VRH T g Q PT V I L AKT VK G F G mge A GEGQNIN -- H Q l KKM GAE AVK A FRDRF G LE 428
Cdd:PRK05899 230 A IEE A KAS T - K PT L I I AKT II G K G --- A PNKEGTH kv H G - APL GAE EIA A AKKEL G WD 282
Transketolase_N
pfam00456 Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes ...
79-438
8.01e-09
Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4. Both these enzymes utilize thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.
Pssm-ID: 395366 [Multi-domain]
Cd Length: 334
Bit Score: 58.17
E-value: 8.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 79 I ER R LNAF IR WN AM AM V LR A G khsgv G GH IATYASA A VLYD V G F DH F FR --- GRTETFAG D - L V YIQ GH S S PGI Y GRAY L 154
Cdd:pfam00456 1 I DK R AVNA IR AL AM DA V EK A N ----- S GH PGAPMGM A PIAE V L F KR F LK hnp NDPKWINR D r F V LSN GH G S MLL Y SLLH L 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 155 E G - RIDEAQ L DN FR reagg Q GL S SY P - HP rlmp D F WQFPT V SMGL GP I ----- T A AYQ A RFM R Y L DLRSLK P EAG --- RK 224
Cdd:pfam00456 76 T G y DLSMED L KS FR ----- Q LG S KT P g HP ---- E F GHTAG V EVTT GP L gqgia N A VGM A IAE R N L AATYNR P GFD ivd HY 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 225 VWA FLGDG EMDQPE S LA A I SLAG REK L D NLI FVVNC N LQRL DG PVRGN ak VIQEFESLYR A A GW N VI K V I wgggwdalla 304
Cdd:pfam00456 147 TYV FLGDG CLMEGV S SE A S SLAG HLG L G NLI VFYDD N QISI DG ETKIS -- FTEDTAARFE A Y GW H VI E V E ---------- 214
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 305 kdrsgllrqrmmecvdgdyqnyksqngayvrehffgkypellalvedlsdddiwklsr G GHD PDKVYN A YAA A VRHTGQ P 384
Cdd:pfam00456 215 ---------------------------------------------------------- D GHD VEAIAA A IEE A KAEKDK P 236
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 256556960 385 T V I LAK TV K G F G m GEAGE G QNIN H Q l KKM GA EA V K A FRDRF G LE va DDQLA EIP 438
Cdd:pfam00456 237 T L I KCR TV I G Y G - SPNKQ G THDV H G - APL GA DE V A A LKQKL G WD -- PYKPF EIP 286
PTZ00089
PTZ00089 transketolase; Provisional
224-428
2.21e-06
transketolase; Provisional
Pssm-ID: 173383 [Multi-domain]
Cd Length: 661
Bit Score: 51.60
E-value: 2.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 224 K V WAFL GDG EMDQPE S LA A I SLAG REK L DN LI FVVNC N LQRL DG P -- VRGNAK V IQEF E SL yraa GW N VI K V iwgggwda 301
Cdd:PTZ00089 150 Y V YVIC GDG CLQEGV S QE A L SLAG HLG L EK LI VLYDD N KITI DG N td LSFTED V EKKY E AY ---- GW H VI E V -------- 217
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 302 llakdrsgllrqrmmecvdgdyqnyksqngayvrehffgkypellalvedlsdddiwkl SR G GH D P D KVYN A YAA A VRHT 381
Cdd:PTZ00089 218 ----------------------------------------------------------- DN G NT D F D GLRK A IEE A KKSK 238
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 256556960 382 G Q P TV I LA KT VK G F G MGE A ge G QNIN H QL k KM G A E AVKAFRDR FGL E 428
Cdd:PTZ00089 239 G K P KL I IV KT TI G Y G SSK A -- G TEKV H GA - PL G D E DIAQVKEL FGL D 282
TPP_enzymes
cd00568 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ...
178-305
1.27e-05
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.
Pssm-ID: 238318 [Multi-domain]
Cd Length: 168
Bit Score: 46.48
E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256556960 178 Y P HP R LMPDFWQFPTVS MG L G PIT A AYQ A RFMR yldlrslkpea G R K V WAFL GDG EMD qp ESLAAISL A G R EK L d NL I F V 257
Cdd:cd00568 31 L P LR R GRRFLTSTGFGA MG Y G LPA A IGA A LAAP ----------- D R P V VCIA GDG GFM -- MTGQELAT A V R YG L - PV I V V 96
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 256556960 258 V NC N -------- L Q RLDGPV R GNAKVIQE -- F ES L YR A A G WNVIK V IWGGGWD A L LA K 305
Cdd:cd00568 97 V FN N ggygtirm H Q EAFYGG R VSGTDLSN pd F AA L AE A Y G AKGVR V EDPEDLE A A LA E 154
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
