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Conserved domains on  [gi|256362611|gb|ACU76108|]
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galactokinase [Catenulispora acidiphila DSM 44928]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
17-417 3.22e-165

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 468.87  E-value: 3.22e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  17 ARRGFHERFGSEPAGVWAAPGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAPRQDRTLRVYAAQLDETVEISLDalvgpg 96
Cdd:COG0153    5 LIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDLD------ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  97 sagdsrdaadpamaPLAEPAVRGWAGYPVGVAWILQQAGFPVGGADVYLTSTVPVGSGLSSSAALECATALALAGVSGFE 176
Cdd:COG0153   79 --------------DLEPGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLG 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 177 LTTAELARHTQRAENIYAGVPCGPLDQMSSAFGQDGSVLYIDTRSGEVRPQPFDLaaENALLLIIDTRVSHAHGENGYAD 256
Cdd:COG0153  145 LDPVELAKIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPL--EGYALVIVDTNVKHSLADSEYNE 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 257 RRSACERAAEFLGVAALRDVSVAELPESFAKVSvglGETFARRLRHVVTEDARVEQFVEILNQEplSLPRLGHRMMQSHA 336
Cdd:COG0153  223 RRAECEAAAAILGVKSLRDVTLEDLEAARARLG---DEVLRRRARHVVTENQRVLEAVEALRAG--DLEAFGKLMNASHA 297

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 337 SLRDDYEVSAPELD-LAVATAVAAGAHGARMTGGGFGGSAIALVDRDLLDDVRAAVVAAFAEHGYTEPQFFPAVASAGAH 415
Cdd:COG0153  298 SLRDDYEVSCPELDtLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGAR 377


                 ..
gi 256362611 416 RI 417
Cdd:COG0153  378 RL 379
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
17-417 3.22e-165

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 468.87  E-value: 3.22e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  17 ARRGFHERFGSEPAGVWAAPGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAPRQDRTLRVYAAQLDETVEISLDalvgpg 96
Cdd:COG0153    5 LIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDLD------ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  97 sagdsrdaadpamaPLAEPAVRGWAGYPVGVAWILQQAGFPVGGADVYLTSTVPVGSGLSSSAALECATALALAGVSGFE 176
Cdd:COG0153   79 --------------DLEPGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLG 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 177 LTTAELARHTQRAENIYAGVPCGPLDQMSSAFGQDGSVLYIDTRSGEVRPQPFDLaaENALLLIIDTRVSHAHGENGYAD 256
Cdd:COG0153  145 LDPVELAKIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPL--EGYALVIVDTNVKHSLADSEYNE 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 257 RRSACERAAEFLGVAALRDVSVAELPESFAKVSvglGETFARRLRHVVTEDARVEQFVEILNQEplSLPRLGHRMMQSHA 336
Cdd:COG0153  223 RRAECEAAAAILGVKSLRDVTLEDLEAARARLG---DEVLRRRARHVVTENQRVLEAVEALRAG--DLEAFGKLMNASHA 297

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 337 SLRDDYEVSAPELD-LAVATAVAAGAHGARMTGGGFGGSAIALVDRDLLDDVRAAVVAAFAEHGYTEPQFFPAVASAGAH 415
Cdd:COG0153  298 SLRDDYEVSCPELDtLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGAR 377


                 ..
gi 256362611 416 RI 417
Cdd:COG0153  378 RL 379
PRK05101 PRK05101
galactokinase; Provisional
 21-417 3.48e-102

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 308.39  E-value: 3.48e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  21 FHERFGSEPAGVWAAPGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAPRQDRTLRVYAAQLD-ETVEISLDAlvgpgsag 99
Cdd:PRK05101  11 FAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAADYDnQQDEFSLDA-------- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 100 dsrdaadpamaPLAEPAVRGWAGYPVGVAWILQQAGFPVGGADVYLTSTVPVGSGLSSSAALECATALALAGVSGFELTT 179
Cdd:PRK05101  83 -----------PIVPHPEQQWANYVRGVVKHLQERNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 180 AELARHTQRAENIYAGVPCGPLDQMSSAFGQDGSVLYIDTRSGEVRPQPFdlaAENALLLIIDTRVSHAHGENGYADRRS 259
Cdd:PRK05101 152 AEIALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPM---PEGVAVVIINSNVKRGLVDSEYNTRRQ 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 260 ACERAAEFLGVAALRDVSVAElpesFAKVSVGLGETFARRLRHVVTEDARVEQFVEILNQEplSLPRLGHRMMQSHASLR 339
Cdd:PRK05101 229 QCETAARFFGVKALRDVTLEQ----FNAVAAELDPVVAKRARHVITENARTLEAASALAAG--DLKRMGELMAESHASMR 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 340 DDYEVSAPELDLAVATAVAAGAHG--ARMTGGGFGGSAIALVDRDLLDDVRAAVVAAFAEHGYTEPQFFPAVASAGAHRI 417
Cdd:PRK05101 303 DDFEITVPQIDTLVEIVKAVIGDQggVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKTGLKETFYVCKASQGAGQC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 21-414 4.93e-86

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 267.08  E-value: 4.93e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611   21 FHERFGSEPAGVWAAPGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAPRQDRTLRVYAAQLD-ETVEISLDalvgpgsag 99
Cdd:TIGR00131   8 FASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADnKFAERSLD--------- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  100 dsrdaadpamAPLAEPAVRGWAGYPVGVAWILQQAGFPVG-GADVYLTSTVPVGSGLSSSAALECATALALAGVSGFELT 178
Cdd:TIGR00131  79 ----------LPLDGSEVSDWANYFKGVLHVAQERFNSFPlGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  179 TAELARHTQRAENIYAGVPCGPLDQMSSAFGQDGSVLYIDTRSGEVRPQPF---DLAaenalLLIIDTRVSHAHGENGYA 255
Cdd:TIGR00131 149 SKQILLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFpqlGIA-----FVIANTNVKRTLAPSNYN 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  256 DRRSACERAAEFLGV---AALRDVSVAELPESFAKVSVGLGETfARRLRHVVTEDARVEQFVEILNQEPLSlpRLGHRMM 332
Cdd:TIGR00131 224 TRRQECTTAANFLAAtdkGALRDFMNEYFARYIARLTKMLPLV-EERAKHVVSENLRVLKAVKAMKDNDFK--QFGALMN 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  333 QSHASLRDDYEVSAPELD-LAVATAVAAGAHGARMTGGGFGGSAIALVDRDLLDDVRAAVVAAFAEHGYTEPQFFPAVAS 411
Cdd:TIGR00131 301 ESHASCDDDYECTCPEIDeLVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSK 380


                  ...
gi 256362611  412 AGA 414
Cdd:TIGR00131 381 PGA 383
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 21-68 8.25e-24

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 93.29  E-value: 8.25e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 256362611   21 FHERFGSEPAGVWAAPGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAP 68
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
17-417 3.22e-165

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 468.87  E-value: 3.22e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  17 ARRGFHERFGSEPAGVWAAPGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAPRQDRTLRVYAAQLDETVEISLDalvgpg 96
Cdd:COG0153    5 LIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDLD------ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  97 sagdsrdaadpamaPLAEPAVRGWAGYPVGVAWILQQAGFPVGGADVYLTSTVPVGSGLSSSAALECATALALAGVSGFE 176
Cdd:COG0153   79 --------------DLEPGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLG 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 177 LTTAELARHTQRAENIYAGVPCGPLDQMSSAFGQDGSVLYIDTRSGEVRPQPFDLaaENALLLIIDTRVSHAHGENGYAD 256
Cdd:COG0153  145 LDPVELAKIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPL--EGYALVIVDTNVKHSLADSEYNE 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 257 RRSACERAAEFLGVAALRDVSVAELPESFAKVSvglGETFARRLRHVVTEDARVEQFVEILNQEplSLPRLGHRMMQSHA 336
Cdd:COG0153  223 RRAECEAAAAILGVKSLRDVTLEDLEAARARLG---DEVLRRRARHVVTENQRVLEAVEALRAG--DLEAFGKLMNASHA 297

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 337 SLRDDYEVSAPELD-LAVATAVAAGAHGARMTGGGFGGSAIALVDRDLLDDVRAAVVAAFAEHGYTEPQFFPAVASAGAH 415
Cdd:COG0153  298 SLRDDYEVSCPELDtLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGAR 377


                 ..
gi 256362611 416 RI 417
Cdd:COG0153  378 RL 379
PRK05101 PRK05101
galactokinase; Provisional
 21-417 3.48e-102

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 308.39  E-value: 3.48e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  21 FHERFGSEPAGVWAAPGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAPRQDRTLRVYAAQLD-ETVEISLDAlvgpgsag 99
Cdd:PRK05101  11 FAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAADYDnQQDEFSLDA-------- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 100 dsrdaadpamaPLAEPAVRGWAGYPVGVAWILQQAGFPVGGADVYLTSTVPVGSGLSSSAALECATALALAGVSGFELTT 179
Cdd:PRK05101  83 -----------PIVPHPEQQWANYVRGVVKHLQERNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 180 AELARHTQRAENIYAGVPCGPLDQMSSAFGQDGSVLYIDTRSGEVRPQPFdlaAENALLLIIDTRVSHAHGENGYADRRS 259
Cdd:PRK05101 152 AEIALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPM---PEGVAVVIINSNVKRGLVDSEYNTRRQ 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 260 ACERAAEFLGVAALRDVSVAElpesFAKVSVGLGETFARRLRHVVTEDARVEQFVEILNQEplSLPRLGHRMMQSHASLR 339
Cdd:PRK05101 229 QCETAARFFGVKALRDVTLEQ----FNAVAAELDPVVAKRARHVITENARTLEAASALAAG--DLKRMGELMAESHASMR 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 340 DDYEVSAPELDLAVATAVAAGAHG--ARMTGGGFGGSAIALVDRDLLDDVRAAVVAAFAEHGYTEPQFFPAVASAGAHRI 417
Cdd:PRK05101 303 DDFEITVPQIDTLVEIVKAVIGDQggVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKTGLKETFYVCKASQGAGQC 382
PRK05322 PRK05322
galactokinase; Provisional
 21-417 6.43e-91

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 279.82  E-value: 6.43e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  21 FHERFGSEPAGVWAAPGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAPRQDRTLRVYAAQLDET--VEISLDALvgpgsa 98
Cdd:PRK05322  10 FAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEDLgiIEFDLDDL------ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  99 gdSRDAADpamaplaepavrGWAGYPVGVAWILQQAGFPV-GGADVYLTSTVPVGSGLSSSAALECATALALAGVSGFEL 177
Cdd:PRK05322  84 --SFDKED------------DWANYPKGVLKFLQEAGYKIdHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 178 TTAELARHTQRAENIYAGVPCGPLDQMSSAFGQDGSVLYIDTRSGEVRPQPFDLaaENALLLIIDTRVSHAHGENGYADR 257
Cdd:PRK05322 150 DRLELVKLGQKTENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDL--GDYVIVIMNTNKRRELADSKYNER 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 258 RSACERAAEFL----GVAALRDVSVAElpesFAKVSVGLG-ETFARRLRHVVTEDARVEQFVEILNQEplSLPRLGHRMM 332
Cdd:PRK05322 228 RAECEKALEELqkklDIKSLGELTEEE----FDEYSYLIKdETLLKRARHAVTENQRTLKAVKALKAG--DLEKFGRLMN 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 333 QSHASLRDDYEVSAPELD-LAVATAVAAGAHGARMTGGGFGGSAIALVDRDLLDDVRAAVVAAFAEH-GYtEPQFFPAVA 410
Cdd:PRK05322 302 ASHVSLRDDYEVTGLELDtLVEAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKiGY-AASFYVAEI 380


                 ....*..
gi 256362611 411 SAGAHRI 417
Cdd:PRK05322 381 GDGAREL 387
PRK03817 PRK03817
galactokinase; Provisional
 35-417 7.59e-90

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 275.72  E-value: 7.59e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  35 APGRVNVIGEHTDYNDGFVLPMAIDRacYAAAAPRQDRTLRVYAAQLDETVEISLDALVGPGSagdsrdaadpamaplae 114
Cdd:PRK03817   5 SPGRVNLIGEHTDYNDGYVLPFAINL--YTFLEIEKSEKFIFYSENFNEEKTFELDKLEKLNS----------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 115 pavrgWAGYPVGVAWILQQAGFPVGGADVYLTSTVPVGSGLSSSAALECATALALAGVSGFELTTAELARHTQRAENIYA 194
Cdd:PRK03817  66 -----WADYIKGVIWVLEKRGYEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFV 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 195 GVPCGPLDQMSSAFGQDGSVLYIDTRSGEVRPQPFDlaaENALLLIIDTRVSHAHGENGYADRRSACERAAEFLGVAALR 274
Cdd:PRK03817 141 GVPCGIMDQFAVAFGKKDHAIFLDTMTLEYEYVPFP---EDYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSK 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 275 DVSVAELPesfakvsvGLGETFARRLRHVVTEDARVEQFVEILNQEplSLPRLGHRMMQSHASLRDDYEVSAPELDLAVA 354
Cdd:PRK03817 218 EVTEEDLS--------KLPPLLRKRAGYVLRENERVLKVRDALKEG--DIETLGELLTESHWDLADNYEVSCEELDFFVE 287

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256362611 355 TAVAAGAHGARMTGGGFGGSAIALVDRDLLDDVRAAVVAAFAEHGYTEPQFFPAVASAGAHRI 417
Cdd:PRK03817 288 FALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKRFGIDPKYFVVESSDGVRKI 350
PRK00555 PRK00555
galactokinase; Provisional
 33-414 2.03e-88

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 272.50  E-value: 2.03e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  33 WAAPGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAPRQDRTLRVYAAQLDETVEISLDAlvGPGSagdsrdaadpamapl 112
Cdd:PRK00555   5 YAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSDRADGSARIPLDT--TPGQ--------------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 113 aepaVRGWAGYPVGVAWILQQAGFPVGGADVYLTSTVPVGSGLSSSAALECATALALAGVSGFELTTAELARHTQRAENI 192
Cdd:PRK00555  68 ----VTGWAAYAAGVIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENE 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 193 YAGVPCGPLDQMSSAFGQDGSVLYIDTRSGEVRPQPFDLAAENALLLIIDTRVSHAHGENGYADRRSACERAAEFLGVAA 272
Cdd:PRK00555 144 YVGAPTGLLDQLAALFGAPKTALLIDFRDLTVRPVAFDPDAAGVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSS 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 273 LRDVSVAELpESFAKVSvglGETFARRLRHVVTEDARVEQFVEILNQEPLSlpRLGHRMMQSHASLRDDYEVSAPELDLA 352
Cdd:PRK00555 224 LRAVQDRGL-AALGAIA---DPIDARRARHVLTENQRVLDFAAALADSDFT--AAGQLLTASHASMRDDFEITTERIDLI 297

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 256362611 353 VATAVAAGAHGARMTGGGFGGSAIALVDRDLLDDVRAAVVAAFAEHGYTEPQFFPAVASAGA 414
Cdd:PRK00555 298 ADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRAAVTAGYPEPAVSRTYAAPGA 359
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 21-414 4.93e-86

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 267.08  E-value: 4.93e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611   21 FHERFGSEPAGVWAAPGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAPRQDRTLRVYAAQLD-ETVEISLDalvgpgsag 99
Cdd:TIGR00131   8 FASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADnKFAERSLD--------- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  100 dsrdaadpamAPLAEPAVRGWAGYPVGVAWILQQAGFPVG-GADVYLTSTVPVGSGLSSSAALECATALALAGVSGFELT 178
Cdd:TIGR00131  79 ----------LPLDGSEVSDWANYFKGVLHVAQERFNSFPlGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  179 TAELARHTQRAENIYAGVPCGPLDQMSSAFGQDGSVLYIDTRSGEVRPQPF---DLAaenalLLIIDTRVSHAHGENGYA 255
Cdd:TIGR00131 149 SKQILLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFpqlGIA-----FVIANTNVKRTLAPSNYN 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  256 DRRSACERAAEFLGV---AALRDVSVAELPESFAKVSVGLGETfARRLRHVVTEDARVEQFVEILNQEPLSlpRLGHRMM 332
Cdd:TIGR00131 224 TRRQECTTAANFLAAtdkGALRDFMNEYFARYIARLTKMLPLV-EERAKHVVSENLRVLKAVKAMKDNDFK--QFGALMN 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  333 QSHASLRDDYEVSAPELD-LAVATAVAAGAHGARMTGGGFGGSAIALVDRDLLDDVRAAVVAAFAEHGYTEPQFFPAVAS 411
Cdd:TIGR00131 301 ESHASCDDDYECTCPEIDeLVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSK 380


                  ...
gi 256362611  412 AGA 414
Cdd:TIGR00131 381 PGA 383
PLN02521 PLN02521
galactokinase
 21-385 8.75e-35

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 134.84  E-value: 8.75e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  21 FHERFGSEPAGVWAAPGRVNVIGEHTDYNDGFVLPMAIdracyaaaapRQDRTLRVYAAQLDETVEIsldalvgpgsaGD 100
Cdd:PLN02521  39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAI----------RQDTIVAIRRAEGSKKLRI-----------AN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 101 SRDAADPAMAPlAEP------AVRGWAGYPV----GVAWILQQAGFPVG---GADVYLTSTVPVGSGLSSSAALECATAL 167
Cdd:PLN02521  98 VNDKYTTCTFP-ADPdqevdlANHKWGNYFIcgykGVFEFLKSKGVDVGppvGLDVVVDGTVPTGSGLSSSAALVCSAAI 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 168 ALAGVSGFELTTAELARHTQRAENiYAGVPCGPLDQMSSAFGQDGSVLYIDTRSgeVRPQPFDLAAENALLLIIDTRVSH 247
Cdd:PLN02521 177 AIMAALGLNFTKKEVAQFTCKCER-HIGTQSGGMDQAISIMAQQGVAKLIDFNP--VRATDVQLPAGGTFVIANSLAESN 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 248 ----AHgENgYADRRSACERAAEFLG-------------VAALRDV------------------SVAEL----------- 281
Cdd:PLN02521 254 kavtAA-TN-YNNRVVECRLAAIVLAvklgmsaeeaiskVKTLSDVeglcvsfagshgssdpavAVKELlhegpytaeei 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 282 ---------------PESFAKVSVGLGETFARRLRHVVTEDARVEQFVEILNQ---EPLSLPRLGHRMMQSHASLRDDYE 343
Cdd:PLN02521 332 eeilgesltsifknsPTSLAVLKAAKHFKLHQRAVHVYSEAKRVHAFRDTVSSslsEEEKLKKLGDLMNESHYSCSVLYE 411

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 256362611 344 VSAPELDLAVATAVAAGAHGARMTGGGFGGSAIALVDRDLLD 385
Cdd:PLN02521 412 CSCPELEELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVP 453
PLN02865 PLN02865
galactokinase
 26-386 1.65e-25

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 107.58  E-value: 1.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  26 GSEPAGVWAAPGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAPRQDRTLRVYAAQLDETVEISLDALVGP-GSAGDSRDA 104
Cdd:PLN02865  26 NSGEVRVVVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFEGEVRFRVDEIQHPiANVSSDSKE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 105 ADpamaplaepavrGWAGYPVGVAWILQQAGFPVGGADVYLTSTVP--VGSGLSSSAALECATALALAGVSGFELTTAEL 182
Cdd:PLN02865 106 ES------------NWGDYARGAVYALQSRGHALSQGITGYISGSEglDSSGLSSSAAVGVAYLLALENANNLTVSPEDN 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 183 ARHTQRAENIYAGVPCGPLDQMSSAFGQDGSVLYIDTRSGEVRPQPFDLAAENALL----LIIDTRVSHAHGEN-GYADR 257
Cdd:PLN02865 174 IELDRLIENEYLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQPGGEKpfkiLLAFSGLRHALTNKpGYNLR 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 258 RSACERAAEFLGVAALRDVSVAEL----PESFAKVSVGLGETFARRLRHVVTEDARVEQFVEILNQEplSLPRLGHRMMQ 333
Cdd:PLN02865 254 VSECQEAARFLLEASGNDELEPLLcnvePEVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEAWASG--NLEEFGKLISA 331

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 256362611 334 SHASLRDDYEVSAPEL-DLAVATAVAAGAHGARMTGGGFGGSAIALVDRDLLDD 386
Cdd:PLN02865 332 SGLSSIENYECGCEPLiQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEE 385
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 21-68 8.25e-24

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 93.29  E-value: 8.25e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 256362611   21 FHERFGSEPAGVWAAPGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAP 68
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PTZ00290 PTZ00290
galactokinase; Provisional
 35-385 1.14e-23

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 102.59  E-value: 1.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  35 APGRVNVIGEHTDYNDGFVLPMAIDRACY---AAAAPRQDRTLRvYAAQLDETVEisLDALvgpgsAGDSRDAAdpamap 111
Cdd:PTZ00290  42 APGRVNFIGEHVDYMGGYVCPAAVLEGCHilvGRVKHFCDHKLR-FATETDEHFV--LDHL-----GGAKHNKA------ 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 112 laepavrgWAGYPVGVAWI-LQQAGFPVG-----GADVYLTSTVPVGSGLSSSAALECATALALAGV-----SGFELTTA 180
Cdd:PTZ00290 108 --------WTTFVRGAATLrLNRLGVAIDapslqGVCMVVHGTLPMGAGMSASASFGVALLNAINTVvtrryKGCPTSPG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 181 ---------------ELARHTQRAENIYAGVPCGPLDQMSSAFGQDGSVLYIDTRSGEVRPQPFD-LAAENALLLIIDTR 244
Cdd:PTZ00290 180 rrysilppmskeeliELAKQARRIETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFESHDMTpLLGDGACFLLIDSM 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 245 VSH---AHGENGYADRRSACERAAEFLGVAALRD--VSVAEL---PE--SFAKVSVGLGETFAR--------RLRHVVTE 306
Cdd:PTZ00290 260 IKHdllGGTAGMYNTVRSDQEGAQKKIGKHRYRGkpFTFSDLvrnPKkyTFDGDVVAFMESCKPlmtpgefeRGTYNIME 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 307 DARVEQFVEiLNQEPLSLPR------LGHRMMQSHASLRDDYEVSAPELD-LAVATAVAAGAHGARMTGGGFGGSAIALV 379
Cdd:PTZ00290 340 QIRTLEFIK-LNDPELPLSReerfrkAGEILNAGHQGMRDLMKITTPELDfIHELINEEKGVAGGRMMGGGFGGCIILLL 418


                 ....*.
gi 256362611 380 DRDLLD 385
Cdd:PTZ00290 419 KKNAVD 424
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 35-379 4.32e-18

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 83.74  E-value: 4.32e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  35 APGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAPRQDRTLRVYAAQLDETVEISldalvgpgsagdsrDAADPAMAPLAE 114
Cdd:COG1577    1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGGTLDLD--------------PLADAALRYIKA 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 115 pavrgwagypvGVAWILQQAGFPVGGADVYLTSTVPVGSGLSSSAALECATALALAGVSGFELTTAELARHTQRAENIYA 194
Cdd:COG1577   67 -----------AIEAALEYLGLPLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLALEAEKIVH 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 195 GVPcGPLDQMSSAFGqdGSVLYidtRSGEvRPQPFDLaAENALLLIIDTRVSHAHGEngyadrrsaceraaeflgvaALR 274
Cdd:COG1577  136 GNP-SGLDTAASTYG--GPIYY---QRGD-RAEPLEL-PKNLPLVVGDTGVPASTKE--------------------LVA 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 275 DvsVAELPESFAKVSVGLGETFARrlrhvVTEDARveqfvEILNQEplSLPRLGHRMMQSHAsLRDDYEVSAPELDLAVA 354
Cdd:COG1577  188 K--VRKLKERNPELYEAFLEEIGD-----LVEEAI-----EALEEG--DLEALGELMNENHG-LLRALGVSTPELDRLVE 252

                        330       340
                 ....*....|....*....|....*
gi 256362611 355 TAVAAGAHGARMTGGGFGGSAIALV 379
Cdd:COG1577  253 AARKAGALGAKLTGAGGGGCVIALA 277
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 142-209 2.74e-12

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 61.41  E-value: 2.74e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 256362611  142 DVYLTSTVPVGSGLSSSAALECATALALAgvsgfELTTAELARHTQRAENIYAGVPCGPLDQMSSAFG 209
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALN-----ELFGLPLAKLALEAEELAGGGRGGGMDVAASLYG 63
PRK03926 PRK03926
mevalonate kinase; Provisional
 137-382 1.12e-08

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 56.21  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 137 PVGGADVYLTSTVPVGSGLSSSAALECATALALAGVSGFELTTAELARHTQRAENIYAGVpCGPLDQMSSAFGqdGSVLY 216
Cdd:PRK03926  72 DKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQGA-ASPTDTYVSTMG--GFVTI 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 217 IDTRSGEvrpqPFDLAaenalLLIIDTRVSHAHGENgyadrrsaceraaeflgVAalrdvSVAELPESFAKVSVGLGETF 296
Cdd:PRK03926 149 PDRKKLP----FPECG-----IVVGYTGSSGSTKEL-----------------VA-----NVRKLKEEYPELIEPILSSI 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 297 ARrlrhvVTEDARveqfvEILNQEPLSlpRLGhRMMQSHASLRDDYEVSAPELDLAVATAVAAGAHGARMTGGGFGGSAI 376
Cdd:PRK03926 198 GK-----ISEKGE-----ELILSGDYV--SLG-ELMNINQGLLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMV 264


                 ....*.
gi 256362611 377 ALVDRD 382
Cdd:PRK03926 265 ALAAPE 270
PLN02677 PLN02677
mevalonate kinase
 35-264 3.80e-04

mevalonate kinase


Pssm-ID: 215363 [Multi-domain]  Cd Length: 387  Bit Score: 42.51  E-value: 3.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611  35 APGRVNVIGEHTDYNDGFVLPMAIDRACYAAAAPR----QDRTLRVYAAQLD-------ETVEISLDALVGPGSAGDSRD 103
Cdd:PLN02677   7 APGKIILAGEHAVVHGSTAVAAAIDLYTYVSLRFPpsaeNDDTLKLQLKDLGlefswplARIKEALPDLGTPCPSTPTSC 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 104 AAD--PAMAPLAE----PAVRGWAGYPVGVAWILQQAGFPVGGADVYLTSTVPVGSGLSSSAALECATALALAGVSG--- 174
Cdd:PLN02677  87 SEEtlKSIAALVEeqniPEAKIWLSSGVSAFLWLYTSILGFNPATVVVTSELPLGSGLGSSAAFCVALSAALLAASDsis 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256362611 175 ----------FELTTAELA-RHTQRAENIYAGVPCGpLDQMSSAFGQdgsvlYIDTRSGEVRpqpfDLAAENAL-LLIID 242
Cdd:PLN02677 167 vstggngwssLDETDLELVnKWAFEGEKIIHGKPSG-IDNTVSTYGN-----MIKFKSGELT----RLQSNMPLkMLITN 236

                        250       260
                 ....*....|....*....|..
gi 256362611 243 TRVshahGENGYADRRSACERA 264
Cdd:PLN02677 237 TRV----GRNTKALVAGVSERA 254
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 125-185 3.08e-03

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 39.31  E-value: 3.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256362611 125 VGVAW--ILQQAGFPVGGADVYLTSTVPVGSGLSSSAALECATALALAGVSGFELTTAELARH 185
Cdd:COG0083   61 VYQAAlaLLEKLGKEPPGLRIEIEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLEL 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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