|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
1-344 |
0e+00 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 550.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 1 MSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP 80
Cdd:cd17343 65 ISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGP 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 81 ILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGK-KGSLKEESTLQELLLSPYLWVLSTG 159
Cdd:cd17343 145 ILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKkKKSPRGESTLKELLLSPFLWLLSLG 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 160 YLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSNYGNPRHGLLLFMMAGMT 239
Cdd:cd17343 225 YLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVFMAGLT 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 240 VSMYLFRVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYS 319
Cdd:cd17343 305 VSLHLFRVHITSDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYD 384
|
330 340
....*....|....*....|....*
gi 256219564 320 WSTAFWVAEVICAASTAAFFLLRNI 344
Cdd:cd17343 385 WRTAFLLLEILCAITVVILFLLRNI 409
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
1-324 |
3.59e-120 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 351.68 E-value: 3.59e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 1 MSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP 80
Cdd:TIGR00881 57 SNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 81 -ILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEG--------KKGSLKEESTLQELLLSP 151
Cdd:TIGR00881 137 pLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEEpdgdaekkEEELTKKQIFLQYVLLNK 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 152 YLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsNYGNPRHGLL 231
Cdd:TIGR00881 217 VLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDK--------LFNGRRGPLA 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 232 LFMMAGMTVSMYLFRVTVTSDspKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPF 311
Cdd:TIGR00881 289 VFFMALIIVSLLVYWLNPAAN--PLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPL 366
|
330
....*....|...
gi 256219564 312 STIAKHYSWSTAF 324
Cdd:TIGR00881 367 GYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
1-342 |
1.22e-91 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 278.39 E-value: 1.22e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 1 MSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP 80
Cdd:cd17312 65 SNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAP 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 81 ILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPadvglrnldpmpsegkkgslkeestlqelllsPYLWVLSTGY 160
Cdd:cd17312 145 ILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP--------------------------------PYVWVLSLAY 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 161 LVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnYGNPRHGLLLFMMAGMTV 240
Cdd:cd17312 193 AFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKL--------FGGRRAPIAVIYMLLMTL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 241 SMYLFRVTVtsdSPKLWILVLGAVFGFSSYGPIALFGVIANESAPP-NLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYS 319
Cdd:cd17312 265 SLALFWFFP---HNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRkEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYG 341
|
330 340
....*....|....*....|...
gi 256219564 320 WSTAFWVAEVICAASTAAFFLLR 342
Cdd:cd17312 342 WSTVFYFLISAALLSVLLLLSLW 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
3-340 |
2.06e-53 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 181.83 E-value: 2.06e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 3 ARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIL 82
Cdd:PRK11663 87 ARYFMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLV 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 83 ATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGL------RNlDPMP----SEGKKGSLKEESTlQELLLSPY 152
Cdd:PRK11663 167 VGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLpsvgewRH-DALElaqqQEGAGLSRKEILT-KYVLLNPY 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 153 LWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnYGNPRHGLLL 232
Cdd:PRK11663 245 IWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKL--------FNGNRGPMNL 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 233 FMMAGMtvsmyLFRVTVTSDSPKLWILVLGAVF---GFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGL 309
Cdd:PRK11663 317 IFAAGI-----LLSVGSLWLMPFASYVMQAACFftiGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGY 391
|
330 340 350
....*....|....*....|....*....|.
gi 256219564 310 PFSTIAKHYSWsTAFWVAEVICAASTAAFFL 340
Cdd:PRK11663 392 PLAKVLEIWHW-TGFFVVISIAAGISALLLL 421
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
3-341 |
7.15e-47 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 162.96 E-value: 7.15e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 3 ARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIL 82
Cdd:cd17488 67 PRYFMGIGLIATGIINILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPIL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 83 ATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPadvglrnldpmpsegkkgslkeestlqelllsPYLWVLSTGYLV 162
Cdd:cd17488 147 TGFAALTYGWRAGMYVPGIIAILMGIVLCWRLRDRP--------------------------------PYIWLLAFCYVL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 163 VFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAkaglsnyGNPRHGLLLFMMAGMTVSM 242
Cdd:cd17488 195 VYVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFK-------GNRGPMNLIFALGLLVSVG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 243 YLFRVTVTSdspkLWIL-VLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWS 321
Cdd:cd17488 268 ALWLVPVHS----YWLLaTCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWS 343
|
330 340
....*....|....*....|
gi 256219564 322 tAFWVAEVICAASTAAFFLL 341
Cdd:cd17488 344 -GFFIVISIAAAISGLLLLP 362
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
2-342 |
9.25e-44 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 155.86 E-value: 9.25e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 2 SARWLFSSGLLLVGLVNIFFA----WSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGG 77
Cdd:cd17345 66 NPKRFLAIGLILSAIINILIGfvpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGG 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 78 LGPILATILAQ---SYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNLDPM----PSEGKKGSLKEESTLQELLL- 149
Cdd:cd17345 146 LVGPLAGLGLAifgDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYkgdyPEEADGEEEEQELSAWEIFVk 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 150 ----SPYLWVLSTG----YLVVFGVktccTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakagls 221
Cdd:cd17345 226 yvlkNKLLWYIAIAnvfvYLVRYGI----LDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKL------- 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 222 nYGNPRHGLLLFMMAGMTVSMylfrVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMAN 301
Cdd:cd17345 295 -FKGRRAPTGIIFMILVIVAL----IVYWLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGY 369
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 256219564 302 VGG-FLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLR 342
Cdd:cd17345 370 LGGsVLATALIGIIVDHFGWNGGFIVLLASCILAIIFLALVA 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-342 |
3.07e-39 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 142.70 E-value: 3.07e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 2 SARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPI 81
Cdd:COG2271 73 GRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPP 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 82 LATILAQSYSWRSTLALSGALCVVVSFLclllihnepadvglrnldpmpsegkkgslkeestlqelllspYLWVLSTGYL 161
Cdd:COG2271 153 LLGWLLAAFGWRAAFLILGLPGLLLALL------------------------------------------RFWLLALAYF 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 162 VVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRHGLLLFMMAGMTVS 241
Cdd:COG2271 191 LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---------LGRRRKLVLAIGLLLAALA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 242 MYLFRVTvtsdSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWS 321
Cdd:COG2271 262 LLLLALL----PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
330 340
....*....|....*....|.
gi 256219564 322 TAFWVAEVICAASTAAFFLLR 342
Cdd:COG2271 338 AAFLLLAALALLAALLALLLL 358
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
4-326 |
1.59e-28 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 114.94 E-value: 1.59e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 4 RWLFSSGLLLVGLVNIFFA---W-SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLG 79
Cdd:TIGR00712 91 RVFLPAGLILSAAVMLLMGfvpWaTSSIAIMFVLLFLNGWFQGMGWPPCGRTMVHWWSQSERGTIVSIWNCAHNIGGGIP 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 80 PILATI-LAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNLDP----MPSEGKKGSLKEEST----LQELLLS 150
Cdd:TIGR00712 171 PLLVLLgMAWFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIEEyrndYPDDYNEKAEQELTAkeifMQYVLPN 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 151 PYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGqSALVGSSYMSAL-EVGGLVGSIAAGYLSDRAM-AKAGLSNYgnprh 228
Cdd:TIGR00712 251 KLLWYIAIANVFVYLLRYGVLDWSPTYLKEVKH-FALDKSSWAYFLyEYAGIPGTLLCGWMSDKVFkGNRGATGV----- 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 229 glllFMMAGMTVSMYLFRVTVTSDSpkLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFL-A 307
Cdd:TIGR00712 325 ----FFMTLVTIAVIVYWMNPAGNP--LVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaA 398
|
330
....*....|....*....
gi 256219564 308 GLPFSTIAKHYSWSTAFWV 326
Cdd:TIGR00712 399 SAIVGYTVDFFGWDGGFMV 417
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-342 |
3.57e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 110.36 E-value: 3.57e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 3 ARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIL 82
Cdd:COG2223 69 PRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFL 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 83 ATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADvglrnldpmPSEGKKGSLKeesTLQELLLSPYLWVLSTGYLV 162
Cdd:COG2223 149 APLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAG---------AAAAAKASLR---DQLEALRDPRFWLLSLLYFG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 163 VFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSM 242
Cdd:COG2223 217 TFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-----------GGRRVLLIVFALMALGL 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 243 YLFrvTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIAnESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHY-SWS 321
Cdd:COG2223 286 LLL--ALALGSLWLFLVLFLLLGLALGGGNGAVFALVP-DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYT 362
|
330 340
....*....|....*....|.
gi 256219564 322 TAFWVAEVICAASTAAFFLLR 342
Cdd:COG2223 363 AAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-307 |
8.80e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.79 E-value: 8.80e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 1 MSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP 80
Cdd:pfam07690 59 FGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGP 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 81 ILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVglrnldpmPSEGKKGSLKEESTLQELLLSPYLWVLSTGY 160
Cdd:pfam07690 139 LLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKR--------PKPAEEARLSLIVAWKALLRDPVLWLLLALL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 161 LVVFGVKTCCTdwGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSnygnprhgLLLFMMAGMTV 240
Cdd:pfam07690 211 LFGFAFFGLLT--YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL--------LALLLLILAAL 280
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 256219564 241 SMYLFRVTVTSdspkLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLA 307
Cdd:pfam07690 281 GLLLLSLTLSS----LWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-307 |
1.15e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 94.27 E-value: 1.15e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 4 RWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILA 83
Cdd:COG2814 75 RRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 84 TILAQSYSWRSTLALSGALCVVVSFLCLLLihnepadvglrnldpMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVV 163
Cdd:COG2814 155 GLLADLFGWRWVFLVNAVLALLALLLLLRL---------------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 164 FGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMY 243
Cdd:COG2814 220 GFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-----------GRRRLLLIGLLLLALGLL 288
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256219564 244 LFRVTVTSdspkLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLA 307
Cdd:COG2814 289 LLALAGSL----WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
4-338 |
1.26e-19 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 88.83 E-value: 1.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 4 RWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILA 83
Cdd:cd17475 61 RRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALL 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 84 TILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPAdvglrnldpmPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVV 163
Cdd:cd17475 141 PPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA----------ASAATESASTLLRSLKEVLRNRDVWLIAIAGALL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 164 FGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsNYGNPRHGLLLFMMAgmTVSMY 243
Cdd:cd17475 211 VAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDR--------VFGGRRRPVLVITAA--IAAAA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 244 LFRVTVTSDSPKLWILVLG-AVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPF-STIAKHYSWS 321
Cdd:cd17475 281 LLVLSLLSPGTPLWLLVLLlILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFgLLVDATHSYA 360
|
330
....*....|....*..
gi 256219564 322 TAFWVAEVICAASTAAF 338
Cdd:cd17475 361 PAWLALALLLVLAALLL 377
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
3-340 |
3.47e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 87.48 E-value: 3.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 3 ARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIL 82
Cdd:cd06174 60 RRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 83 ATILAQ--SYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGKKGslkeestLQELLLSPYLWVLSTGY 160
Cdd:cd06174 140 GGILASslGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL-------LKRVLKNPGLWLLLLAI 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 161 LVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnyGNPRHGLLLFMMAGMTV 240
Cdd:cd06174 213 FLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR----------LIGRKPLLLIGLLLMAL 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 241 SMYLFRVTvtsdSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSW 320
Cdd:cd06174 283 GLALLLLA----PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG 358
|
330 340
....*....|....*....|
gi 256219564 321 STAFWVAEVICAASTAAFFL 340
Cdd:cd06174 359 LTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
1-341 |
9.29e-19 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 86.09 E-value: 9.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 1 MSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP 80
Cdd:cd17319 65 FGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGP 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 81 ILATILAQSYSWRSTLALSGALCVVVSFLCLLLIhnePADVGLrnldpmpsegkkgslkeesTLQELLLSPYLWVLSTgy 160
Cdd:cd17319 145 PLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL---RQVWGL-------------------ALGYFGINYALYGLLT-- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 161 lvvfgvktcctdWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAglsnygnpRHGLLLFMMAGMTV 240
Cdd:cd17319 201 ------------WLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA--------RRLVIIIGLLLAAV 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 241 SMYLFrvtVTSDSPKLWILVLGAVFGFsSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKH-YS 319
Cdd:cd17319 261 GLLLA---YLTTSPVVAVILLSLAGFG-IGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtGS 336
|
330 340
....*....|....*....|..
gi 256219564 320 WSTAFWVAEVICAASTAAFFLL 341
Cdd:cd17319 337 YTAAFLFLAAVALLAALLVLLL 358
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
4-341 |
2.12e-18 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 85.92 E-value: 2.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 4 RWLFSSGLLLVGLVNIFFAW----SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGL- 78
Cdd:PRK11273 93 RVFLPAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLp 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 79 GPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGL------RNLDPmpsEGKKGSLKEESTLQEL----- 147
Cdd:PRK11273 173 PLLFLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLppieeyKNDYP---DDYNEKHEQELTAKQIfmqyv 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 148 LLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLiQEKGQSALVGSSYMSAL-EVGGLVGSIAAGYLSDRAMAkaglsnyGNp 226
Cdd:PRK11273 250 LPNKLLWYIAIANVFVYLLRYGILDWSPTYL-KEVKHFALDKSSWAYFLyEYAGIPGTLLCGWMSDKVFR-------GN- 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 227 RHGLLLFMMAGMTVSMYLFRVTvTSDSPKLWILVLGAVfGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFL 306
Cdd:PRK11273 321 RGATGVFFMTLVTIATIVYWLN-PAGNPTVDMACMIVI-GFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSV 398
|
330 340 350
....*....|....*....|....*....|....*....
gi 256219564 307 AGlpfSTI----AKHYSWSTAFWVaeVICAASTAAFFLL 341
Cdd:PRK11273 399 AA---SAIvgytVDFFGWDGGFMV--MIGGSILAVILLI 432
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
4-342 |
2.41e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 79.16 E-value: 2.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 4 RWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILA 83
Cdd:cd17325 61 KRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 84 TILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPadvglrnldPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVV 163
Cdd:cd17325 141 GLLADALGYRAPFLVCAALALLALVLALLLLPEPR---------PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 164 FGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMY 243
Cdd:cd17325 212 AFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-----------GRKPLILIGLLLSAVALL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 244 LFRVtvtsdSPKLWILVLGAVF---GFSSYGPiALFGVIAnESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSW 320
Cdd:cd17325 281 LLPL-----ATSFWLLLLLLALlglGLGLVFP-ATLALLA-DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF 353
|
330 340
....*....|....*....|..
gi 256219564 321 STAFWVAEVICAASTAAFFLLR 342
Cdd:cd17325 354 ATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
3-339 |
3.34e-14 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 73.07 E-value: 3.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 3 ARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQ--GLGWPPCGKVLRKWFEPSQfGTWWAILSTSMNLAGGLGP 80
Cdd:cd17355 67 PRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGagTLAAVAFATVAAWWFERRR-GLALGILTAGGGLGSLVFL 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 81 ILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGkkgslkEESTLQELLLSPYLWVLSTGY 160
Cdd:cd17355 146 PLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPAS------PGSTLKEALRSASFWLLALAF 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 161 LVVfGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRHGLLLFMMAGMTV 240
Cdd:cd17355 220 FLC-GFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR---------YSPRRLLAASYALRALGL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 241 SMYLFrvtvtSDSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHY-S 319
Cdd:cd17355 290 ALLLL-----LPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgS 364
|
330 340
....*....|....*....|
gi 256219564 320 WSTAFWVAEVICAASTAAFF 339
Cdd:cd17355 365 YTAAWALAVALGLIAALLVL 384
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
1-339 |
6.92e-14 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 71.82 E-value: 6.92e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 1 MSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKwFEPSQFGTWWAILSTSMNLAGGLGP 80
Cdd:cd17478 58 KPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 81 ILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHnepadvglRNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGY 160
Cdd:cd17478 137 LIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP--------LKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRS 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 161 LVVFGVKTCCTdwgqfFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAglsnygnprhgLLLFMMAGMTV 240
Cdd:cd17478 209 WVLSSLTTFLP-----FYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRR-----------VIIASLLLAAP 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 241 SMYLFRVTvtsdsPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLcGTSHAIVGLMANVGGFLAGLPFSTIAKHYSW 320
Cdd:cd17478 273 FLLLFLLT-----PGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNV-GLASGLMMGLSFGLGGIGAPVLGALADAFGL 346
|
330
....*....|....*....
gi 256219564 321 STAFWVAEVICAASTAAFF 339
Cdd:cd17478 347 ESVLLILALLPLLGALLAF 365
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
6-346 |
2.08e-13 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 70.85 E-value: 2.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 6 LFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATI 85
Cdd:PRK09556 101 LILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALW 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 86 LAQSYSWRSTLAL---SGALCVVVSFLCLLLIHNEPADVGLRN--------LDPMPSEGKKGSL-KEESTLQELLLSPYL 153
Cdd:PRK09556 181 GANYFFDGHVIGMfifPSIIALIIGFIGLRYGSDSPEELGWGKaeeifgepISEEDKETESTDMtKWQIFVEYVLKNPVI 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 154 WVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygNPRHGLLLF 233
Cdd:PRK09556 261 WLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLA----------NGRRALVAC 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 234 MMAGMTVSMYLFRVTVTSDspklwILVLGAVF--GFSSYGPIALFGVIANESAPPN--------------LCGTSHAIVG 297
Cdd:PRK09556 331 IALALIIFTLGVYQHATSE-----YMYLASLFalGFLVFGPQLLIGVAAVGFVPKKaigvangikgtfayLFGDSFAKVG 405
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 256219564 298 LMANVGGFLAGLPFSTIAKHySWS---TAFWVAEVICAASTA--AFFLLRNIRT 346
Cdd:PRK09556 406 LGMIADPTKNGTPIFGYTLT-GWAgtfAALDIAAIGCICLMAivAVMEERKIRR 458
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
2-341 |
7.30e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 69.13 E-value: 7.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 2 SARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFePSQFGTWWAILSTSMNLAGGLGPI 81
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAG 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 82 LATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADvglrnldpmpsegkKGSLKEESTLQELLLSPYLWVLSTGYL 161
Cdd:COG2807 160 LTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA--------------AAAAPAAASLRSLWRSPLAWLLTLFFG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 162 VVFGVKTCCTDWGQFFLiQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygNPRHGLLLFMMAGMTVS 241
Cdd:COG2807 226 LQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL----------GDRRPLLLLLGLLGLAG 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 242 MYLFrVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANESAP-PNLCGTSHAIVGLMANVGGFLAGLPFSTIAkhySW 320
Cdd:COG2807 295 LLGL-LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATG---SW 370
|
330 340
....*....|....*....|.
gi 256219564 321 STAFWVAEVICAASTAAFFLL 341
Cdd:COG2807 371 TAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
6-339 |
1.01e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 62.18 E-value: 1.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 6 LFSSGLLLVGLVNIFFAWSSTVPVFAAlwFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATI 85
Cdd:cd17324 68 LVLLLLFILGNLLAALAPSFALLLLAR--ALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGL 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 86 LAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPAdvglrnldpmpseGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFG 165
Cdd:cd17324 146 LGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPP-------------KKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 166 VKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAglsnygnprhglLLFMMAGMTVSMYLF 245
Cdd:cd17324 213 GFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA------------LLIALLLLAAALLLL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 246 rvTVTSDSPKLWILVLgAVFGFSSYGPIALFGVIANESAPPNLcGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFW 325
Cdd:cd17324 281 --TLLGPSPLLLLVGL-VLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW 356
|
330
....*....|....
gi 256219564 326 VAEVICAASTAAFF 339
Cdd:cd17324 357 VGAALLLLALLLAL 370
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
10-341 |
2.32e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 58.35 E-value: 2.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 10 GLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAqS 89
Cdd:cd17474 70 GLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-A 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 90 YSWRSTLALSGALCVVvSFLCLLLIHNEPadvglrnldpmPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTC 169
Cdd:cd17474 149 ISWRYPFFLLAALIPV-AFLAILFLLPEP-----------KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFA 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 170 CTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygNPRHGLLLFMMAGMTVSMYLFRVTv 249
Cdd:cd17474 217 FLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR----------FGARRILVIGLLLYALSLLLLGFV- 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 250 tsdsPKLWILVLG-AVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAE 328
Cdd:cd17474 286 ----PSLALLLIAiVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGA 361
|
330
....*....|...
gi 256219564 329 VICAASTAAFFLL 341
Cdd:cd17474 362 AIALAAAVLLALL 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
9-341 |
7.91e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.47 E-value: 7.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 9 SGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQ 88
Cdd:cd06173 74 RALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVA 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 89 SYSWRSTLALSgALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGKKGslkeestLQELLLSPYLWVLSTGYLVVFGVKT 168
Cdd:cd06173 154 LLGPGGAFAIN-ALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREG-------LRYLRRSPLLRLLLLALALFALLGG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 169 CCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnygNPRHGLLLFMMAGMTVSMYLFRVt 248
Cdd:cd06173 226 ALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR-----------RRRGRLLLIGALLLGLALLVLGL- 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 249 vtsdSPKLWILVLGAVFGFSSYGPI-ALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVA 327
Cdd:cd06173 294 ----SPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLA 369
|
330
....*....|....
gi 256219564 328 EVICAASTAAFFLL 341
Cdd:cd06173 370 GALLLLAALLLLLL 383
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
10-309 |
4.90e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 54.28 E-value: 4.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 10 GLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCgKVLRKWFEPSQF-GTWWAILSTSMNLAGGLGPILATILAQ 88
Cdd:TIGR00895 88 SILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNL-NALVSEYAPKRFrGTAVGLMFCGYPIGAAVGGFLAGWLIP 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 89 SYSWRSTLALSGA-----LCVVVSFL-------------CLLLIHNEPADVGLRNLDPMPSE------GKKGSLKEESTL 144
Cdd:TIGR00895 167 VFGWRSLFYVGGIaplllLLLLMRFLpesidflvskrpeTVRRIVNAIAPQMQAEAQSALPEqkstqgTKRSVFKALFQG 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 145 QELLLSPYLWVL-STGYLVVFGVktccTDWGQFfLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsny 223
Cdd:TIGR00895 247 KTARITVLLWLLyFMLLVGVYFL----TNWLPK-LMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL--------- 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 224 gNPRHGLLLFMMAGMTVSMYLFRVTvtsdSPKLwILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTShaiVGLMANVG 303
Cdd:TIGR00895 313 -GPRVTALLLLLGAVFAVLVGSTLF----SPTL-LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATG---VGWAIGIG 383
|
....*.
gi 256219564 304 GFLAGL 309
Cdd:TIGR00895 384 RLGAII 389
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
4-339 |
7.20e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 53.78 E-value: 7.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 4 RWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILA 83
Cdd:cd17328 64 KWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 84 TILAQS-YSWRSTLALSGALCVVVSFLCLLLIHNEPadvgLRNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLV 162
Cdd:cd17328 144 GLVAQAtGGWRWAFRVTGVLGVLLAILLLLFVREPP----RGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAV 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 163 VFGVKTCCTDWGQFFLI---QEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKaglsnygNPRHGLLL--FMMAG 237
Cdd:cd17328 220 SFVTGALAFWAPTFFLRafgVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRK-------TPRADPLVcaVGLLA 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 238 MTVSMYLFRVTVTSDSPKLWILV-LGAVFGFSSYGPIAlfgVIANESAPPNLCGTSHAIVGLMAN-----VGGFLAGLPF 311
Cdd:cd17328 293 AAPFLFLALVLALSNLLLAWVLLfLGEFLLSLNWAPVF---AILLYVVIPTRRSTASAIQILLSHllgdaGSPYLIGLIS 369
|
330 340 350
....*....|....*....|....*....|....*.
gi 256219564 312 STIAKHY--------SWSTAFWVAEVICAASTAAFF 339
Cdd:cd17328 370 DLLRQNKdsplaeaaSLQYALLLCSFVLVLGGFFFL 405
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
4-347 |
1.38e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.85 E-value: 1.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 4 RWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRkWFEPSQFGTWWAILSTSMNLAGGLGPILA 83
Cdd:COG0738 73 KRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 84 TILAQ---SYSWRSTLALSGALCVVVSFLCLLLIHnepadvglrnldPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGY 160
Cdd:COG0738 152 GLLILlglSLSWHLPYLILAVLLLLLALLFLRSKL------------PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAI 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 161 LVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTV 240
Cdd:COG0738 220 FLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-----------GPVRLLRLSALLAAV 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 241 SMYLFRVTvtsdsPKLWILVLGAV---FGFSSYGPIALfgVIANESAPPNLCGTShAIVGLMANVGGFLAGLPFSTIAKH 317
Cdd:COG0738 289 GLLLALLA-----PGPWLALIGLAlvgLGLSLMFPTIF--SLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADA 360
|
330 340 350
....*....|....*....|....*....|
gi 256219564 318 YSWSTAFWVAEVICAASTAAFFLLRNIRTK 347
Cdd:COG0738 361 FGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
4-339 |
1.60e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.52 E-value: 1.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 4 RWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMN----LAGGLG 79
Cdd:cd17316 66 KKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAlgalLAALVA 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 80 PILATILAQSYSWRSTLALSGALCVVVsflclllihnepadvglrnldpmpsegkkgslkeestlqeLLLSPYLWVLSTG 159
Cdd:cd17316 146 SLLIPLLSGDWGWRILFLIGALPALLA----------------------------------------LLLRRRTLLLILL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 160 YLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMT 239
Cdd:cd17316 186 WFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-----------GRKKTLVIGLILSG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 240 VSMYLFRVTVTSDSPklWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMAN-VGGFLAGLPFSTIAKHY 318
Cdd:cd17316 255 ILALPLFYLLSGSPT--LLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRlGGGGAPPLIALLLASTG 332
|
330 340
....*....|....*....|.
gi 256219564 319 SWSTAFWVAEVICAASTAAFF 339
Cdd:cd17316 333 GTGVPALILALLAIVALIVAL 353
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
1-113 |
2.98e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.77 E-value: 2.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 1 MSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP 80
Cdd:cd06173 271 RRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGA 350
|
90 100 110
....*....|....*....|....*....|...
gi 256219564 81 ILATILAQSYSWRSTLALSGALCVVVSFLCLLL 113
Cdd:cd06173 351 LLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
5-341 |
4.60e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.99 E-value: 4.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 5 WLFSSGLLLVGLVNiffawsSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFePSQFGtwwaiLSTSMNLAG-GLGPI-- 81
Cdd:cd17353 76 ILFGLGFILSAFAI------SLPLLFLGYGVLGGIGAGIGYITPVSTAVKWF-PDKRG-----LATGIVIAGfGLGSLif 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 82 --LATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGlrNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLstg 159
Cdd:cd17353 144 spLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWV--PPGVDPLANNAENSPRDYTPREMLRTPTFWLL--- 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 160 YLVVFgvktCCTDWGQF-------FLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGnpRHGLLL 232
Cdd:cd17353 219 WLMFF----LNATAGLMligqakpIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDK---------IG--RKNTLS 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 233 FMMAGMTVSMYLFrvtVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFS 312
Cdd:cd17353 284 IAFLIQGVAMFLL---PFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA 360
|
330 340
....*....|....*....|....*....
gi 256219564 313 TIAKHYSWSTAFWVAevICAASTAAFFLL 341
Cdd:cd17353 361 YVLYTGGYNAAFIIA--AALSLVALALAL 387
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
2-113 |
1.84e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.07 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 2 SARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPI 81
Cdd:cd17329 63 GRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPL 142
|
90 100 110
....*....|....*....|....*....|..
gi 256219564 82 LATILAQSYSwrSTLALSGALCVVVSFLCLLL 113
Cdd:cd17329 143 LGGLLLLYSF--RLLFLAAAVLFLLAALVLLF 172
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
1-332 |
1.97e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.16 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 1 MSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGwPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP 80
Cdd:cd17333 58 LGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGIL-DTGANTFVGALFEESSATRLNVLHGFFGLGALIGP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 81 ILAT-ILAQSYSWRSTLALSGALCVVVsFLCLLLIHNEPadvglrnlDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTG 159
Cdd:cd17333 137 LIATsLLTSELSWSWAYLIIGLIYLLL-AILILLTLFPE--------LPSARNPQQSVGAFSASASRLLRNPSIILGALA 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 160 YLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAglsnygnprhglllFMMAGMT 239
Cdd:cd17333 208 LFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHT--------------LLVLSGS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 240 VSMYLFRVTVTSDSPkLWILVLGAVFGFSSYGPIALFGVIANESAP-PNLCGTSHAIVglMANVGGFLAGLPFSTIAKHY 318
Cdd:cd17333 274 GALLGLLILLLAPTL-VVGLVATALLGLFMAALFPTILSLGISNLPyAKGKGTSVLLA--AGSIGGAIIPFIMGFIAEAV 350
|
330
....*....|....
gi 256219564 319 SWSTAFWVAEVICA 332
Cdd:cd17333 351 GIQTAMLLITILYA 364
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
177-341 |
2.97e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 45.37 E-value: 2.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 177 FLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRHGLLLFMMAGMTVSMYLFrvtvTSDSPKL 256
Cdd:cd17371 235 YLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADR---------IGRRNNFALFALGSAISILLYFF----LPLSPTL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 257 wILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAF-WVAEVICAAST 335
Cdd:cd17371 302 -ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIaVFAAVYYIAGL 380
|
....*.
gi 256219564 336 AAFFLL 341
Cdd:cd17371 381 VLALLL 386
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
6-304 |
4.76e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.86 E-value: 4.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 6 LFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATI 85
Cdd:cd17321 63 VFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGL 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 86 LAQSYSWRSTLALSGALCVVVsflclllihnepadvglrnldpmpsegkkgslkeestlqeLLLSPYLWVLSTGYLVVFG 165
Cdd:cd17321 143 LLELFGWRWIFLINVPIGLVA----------------------------------------LLLARTFSGAVLAAFLLGA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 166 VKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAglsnygnprhgLLLFMMAGMTVSMYLF 245
Cdd:cd17321 183 ALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRL-----------VLVAGLLLTAVGLLLL 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 256219564 246 RVTVTSDSPKLWILVLgAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGG 304
Cdd:cd17321 252 ALLGADSSVWLLLPGL-VLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGG 309
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
3-340 |
5.73e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.55 E-value: 5.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 3 ARWLFSSGLLLVGLVNIFFAWSSTVP-VFAALWFLNGLAqGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPI 81
Cdd:cd17341 63 GRRVFIASLLLLLIPLLALALAVSSYwGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 82 LATILAQS-------YSWRSTLALSGALCVVVSFLCLLLIHNEPadvglrnldpmpsEGKKGSLKEESTLQELLLSPYLW 154
Cdd:cd17341 142 LAPLIAGAivfdggfVGWRNAFFVPGILLAIAAVLVLLFGDDLP-------------TGKASALEFLKVQLAVLKNYRTW 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 155 VLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKaglsnygnprhGLLLFM 234
Cdd:cd17341 209 ILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGR-----------RRLWWL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 235 MAGMTVSMYLFRVTVTSDSPKLWILVLGAVFGFSSYGPI--ALFGVIANESapPNLCGTSHAIVGLMANVGGFLAGLPFS 312
Cdd:cd17341 278 FIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGngSVFRMVPFIF--RRELGAVTGLVGAIGGLGGFFLPLLFG 355
|
330 340
....*....|....*....|....*....
gi 256219564 313 TIAK-HYSWSTAFWVAEVICAASTAAFFL 340
Cdd:cd17341 356 SSALmTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
10-115 |
7.23e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 42.25 E-value: 7.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 10 GLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQS 89
Cdd:TIGR00880 34 GLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQF 113
|
90 100
....*....|....*....|....*.
gi 256219564 90 YSWRSTLALSGALCVVVSFLCLLLIH 115
Cdd:TIGR00880 114 LGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
4-124 |
1.08e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 43.65 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 4 RWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILA 83
Cdd:COG0477 79 KRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 256219564 84 TILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLR 124
Cdd:COG0477 159 GLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALL 199
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
10-308 |
1.75e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.95 E-value: 1.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 10 GLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQS 89
Cdd:cd17320 70 GLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLF 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 90 YSWRSTLALSGALCVVVSFLCLLLIhnepadvglrnldPMPSEGKKGSLKEESTLQ---ELLLSPYLWVLSTGYLVVFGV 166
Cdd:cd17320 150 FGWRAIFVFLALLGLLLLLLVLLFL-------------PETLPEEKRKPLLSSLLRaykRVLKNRRFLGYALALGLSFAG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 167 KTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLsnygnpRHGLLLFMMAGMTVSmyLFR 246
Cdd:cd17320 217 LFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL------RLGLLLLLAAALVLL--LAA 288
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 256219564 247 VTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIaneSAPPNLCGTSHAIVGLMANVGGFLAG 308
Cdd:cd17320 289 LLGGLSLWPLVAPLFLIFFGFGLIFPNATSLAL---EPFPHVAGTASALLGFLQFLIGALAG 347
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
177-341 |
2.11e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.65 E-value: 2.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 177 FLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFrvtVTSDSPkL 256
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-----------GRRRVLLLGLLLFALGSLLC---ALAPSL-W 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 257 WILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTA 336
Cdd:COG2814 100 LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALL 179
|
....*
gi 256219564 337 AFFLL 341
Cdd:COG2814 180 LLLRL 184
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
194-341 |
4.75e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.84 E-value: 4.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 194 SALEVGGLVGSIAAGYLSDRamakaglsnYGNPRhgLLLFMMAGMTVSMYLFRVTVTsdspkLWILVLGAVFGFSSYGPI 273
Cdd:cd17475 38 SALNLGVAVSMLPAGWLLDR---------FGERR--VLAVGLLLMGAAALLMALVGS-----YPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256219564 274 ALFGVIA-NESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLL 341
Cdd:cd17475 102 QPGGGRAiMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLF 170
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
68-356 |
4.77e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 4.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 68 LSTSMNLAGGLGPILATILA----------QSYSWRSTLALSGALCVVVSFLCLLLIHnepadvglrnlDPMPSEGKKGS 137
Cdd:COG2211 148 LSSWRFAFAGLGGLLASVLPpplvaafggdAALGYRLTALIFAVLGLLAFLLTFFGTK-----------ERPVPEEEKVS 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 138 LKEesTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamak 217
Cdd:COG2211 217 LKE--SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR---- 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 218 aglsnYGnpRHGLLLFMMAGMTVSMYLFRVTVTSDSPklWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSH---- 293
Cdd:COG2211 291 -----FG--KKKAFIIGLLLAALGLLLLFFLGPGNLW--LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRrreg 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 294 ------------------AIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLRNIRTKMGRVSKKA 355
Cdd:COG2211 362 lyfgiftfaiklgqalagALAGLLLALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAEL 441
|
.
gi 256219564 356 E 356
Cdd:COG2211 442 A 442
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
183-341 |
1.22e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 183 GQSALVGSSYMSALEVGGLVgsiaAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLfrvtvTSDSPKLWILVLG 262
Cdd:cd17324 34 AQAGLLVSAYALGYALGALL----LGPLSDRI-----------ERRRLLLVLLLLFILGNLL-----AALAPSFALLLLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 263 -AVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVgLMANVGGFLAGLPFST-IAKHYSWSTAFWVAEVICAASTAAFFL 340
Cdd:cd17324 94 rALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLGRPLGGlLGQLLGWRAAFLAIAVLALLAALLLWR 172
|
.
gi 256219564 341 L 341
Cdd:cd17324 173 L 173
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
4-308 |
1.33e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 40.31 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 4 RWLFSSgLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILA 83
Cdd:cd17327 72 KWLSVF-IVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLA 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 84 TILAQS------YSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRN-------LDPMPSEGKKGSLKEE--STLQELL 148
Cdd:cd17327 151 YGVFKIlgvgglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTeeekelaVERLRANQTGKGDQKFkwKQIKEAF 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 149 LSPYLWVLStgyLVVFGVKTCCTDWGQF-FLIQEKGQSALVGSSYMS-ALEVGGLVGSIAAGYLSDRAmakaglsnygnp 226
Cdd:cd17327 231 KDPRTWLLF---LFFFCSQITNNGISNFlPLILKSLGFYSLQTNLLSvPIGALGAVSLLIAALLSDRF------------ 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 227 rHGLLLFMMAGMTVSMYLFRVTVTSDSPklWILVLGAVF--GFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGG 304
Cdd:cd17327 296 -KKRGLFAIFACVLALVGSIILLAAPNP--PGAYFAAYIlgGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGN 372
|
....
gi 256219564 305 FLAG 308
Cdd:cd17327 373 IVAP 376
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
183-341 |
1.53e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 40.25 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 183 GQSALVGSSYMSALEVgglVGSIAAGYLSDRAMakaglsnygnpRHGLLLFMMAGMTVSMYL---FRVTVTSDSPKLWIL 259
Cdd:cd17315 213 GTASILASIIVGVVNL---LATLVAIRLVDKVG-----------RRPLLLIGFAGMAASLLLlaiAFLLPALAKAAGWLA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 260 VLGA---VFGFS-SYGPIalFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAAST 335
Cdd:cd17315 279 LLGIllyIAAFAmGAGPV--PWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLAL 356
|
....*.
gi 256219564 336 AAFFLL 341
Cdd:cd17315 357 VFVFFF 362
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
1-342 |
1.76e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.88 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 1 MSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP 80
Cdd:cd17489 58 FGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGP 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 81 ILATILAQSYSWRStLALSGALCVVVSFLCLLLIHNEPAdvglrnldPMPSEGKKGSLKEESTLQELLLSPYLWVLSTG- 159
Cdd:cd17489 138 ALGLFLYQHLGFAV-LFIVAAVLALLALLLVFLVKDPPP--------VAAEEAEAGTRAFRRLVEKKVLPPALILFLASi 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 160 -------YLVVFGVKTCCTDWGQFFLIQekgQSALVGSSYMSalevgglvgsiaaGYLSDramakaglsnygnpRHGLLL 232
Cdd:cd17489 209 aygaistFLPLYAAERGISNAGLFFTVY---AIALLLSRPFS-------------GKLSD--------------RKGPKT 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 233 FMMAGMTVsmYLFRVTVTSDSPKLWILVLGAVF---GFSSYGPIalFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGL 309
Cdd:cd17489 259 VIIPGLLL--LALGLLLLSFAGSPWMLLLAAVLyglGFGLLFPA--LQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGL 334
|
330 340 350
....*....|....*....|....*....|...
gi 256219564 310 PFSTIAKHYSWSTAFWVAEVICAASTAAFFLLR 342
Cdd:cd17489 335 LLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
177-356 |
2.50e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.32 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 177 FLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRhgLLLFMMAGMTVSMYLFRVTVTSdspkL 256
Cdd:pfam07690 22 LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR---------FGRRR--VLLIGLLLFALGLLLLLFASSL----W 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 257 WILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTA 336
Cdd:pfam07690 87 LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV 166
|
170 180
....*....|....*....|
gi 256219564 337 AFFLLRNIRTKMGRVSKKAE 356
Cdd:pfam07690 167 LLLLPRPPPESKRPKPAEEA 186
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
4-271 |
3.11e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 39.10 E-value: 3.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 4 RWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILA 83
Cdd:cd17323 64 RPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 84 TILAQSYSWRST---LALSGALCVVVSFLCLLLIhnepadvglrnldpmpsegkkgslkeestlqeLLLSPY-------L 153
Cdd:cd17323 144 GFITQSLGWRWIfwfLAIISGFCLILIFLFLPIV--------------------------------LLLGLYvglvyaiL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 154 WVLSTGYLVVFGVKTCCTDWGqffliqekgqsalVGSSYMSALeVGGLVGSIAAGYLSDRAMAKAGLSNYGNPR-HGLLL 232
Cdd:cd17323 192 YLFLTAFPYVFGEVYGFSPGE-------------VGLMYLPIG-IGALIGSIIGGRLSDYYYRRLKKKNGGKPEpEARLP 257
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 256219564 233 FMMAG---MTVSMYLFRVTVTSDSPKLWILVLGAVFGFSSYG 271
Cdd:cd17323 258 PAFIGaflFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLML 299
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
10-342 |
4.35e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.69 E-value: 4.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 10 GLLLVGLVNIFFAWSSTVPVF-AALWFLNGLAQGLGWPPCGKVLRKWFEPsqfgtwWAILSTSMNLAG-GLG----PILA 83
Cdd:cd17352 74 GGLLAALGLLLSSFATSLWQLyLTYGVLGGLGLGLIYSPAIVIVGQYFEK------KRGLATGIAVAGsGVGtfvfPPLL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 84 TILAQSYSWRSTLALSGALCVVVSFLCLLLIhnepadvglrnldpmpsegkkgslkeestlqeLLLSP-YLWVLSTGYLV 162
Cdd:cd17352 148 RYLLDNYGWRGALLILGGLCLNLCVCGLLLR--------------------------------LLKDPtFVLLALGVSFA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 163 VFGVKTCCTdwGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnygnPRHGLLLFMMAGMTVS- 241
Cdd:cd17352 196 MLGFFVPFV--YLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADK------------PRIGRLYLYIFTLLILg 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 242 MYLFRVTVTSDSPKLWilVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGfLAGLPFS--TIAKHYS 319
Cdd:cd17352 262 LSLLAFPLATTYVGLI--VFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAA-LVGPPIAglLRDYTGD 338
|
330 340
....*....|....*....|...
gi 256219564 320 WSTAFWVAEVICAASTAAFFLLR 342
Cdd:cd17352 339 YDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
174-341 |
4.53e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 38.78 E-value: 4.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 174 GQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGnpRHGLLLFMMAGMTVSMYLFRVTVTSDS 253
Cdd:cd17357 36 DRYGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANR---------FG--RKNGLLISNALLVVSSLLMFLSKSAKS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 254 PKLWIL--VLGAVFGFSSYGPIALFgviANESAPPNLCGTSHAIVGLMANVG---GFLAGLPFsTIAKHYSWSTAFWVAE 328
Cdd:cd17357 105 PELLIFgrFLVGIACGLSTGFVPMY---LQEISPSELRGALGSLTQIGVTLGillGQVFGLPS-VLGTETLWPYLLFFPG 180
|
170
....*....|...
gi 256219564 329 VICAASTAAFFLL 341
Cdd:cd17357 181 IPALLQLAALPFF 193
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
1-342 |
4.61e-03 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 38.84 E-value: 4.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 1 MSARWLFSSGLLLVGLVNIFFAWS-----STVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLA 75
Cdd:cd17344 89 LPLRYFLSFGMLLSGLFTALFGLGyywniHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGIWNSHTSVG 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 76 GGLGPILATILAqSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVglrnldpmpsegkkgslkeestlqelllSPYLWV 155
Cdd:cd17344 169 NILGSLIAGIFV-SSAWGLSFIVPGIIIAAMGVLVFLFLVEHPPGV----------------------------IEFSLC 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 156 LSTGYLVVFGVKTcctdWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSnygnprhGLLLFMM 235
Cdd:cd17344 220 LFFAKLVSYTFLY----WLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTC-------AAMLILA 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 236 AGMtvsMYLFRvTVTSDSPKLWILVLgAVFGFSSYGPIALF--GVIANESAPPNLCGTSHAI------------VGlmAN 301
Cdd:cd17344 289 APM---LFIYN-YFGQVSMTTNIVLL-IVCGLLVNGPYALIttAVSADLGTHKSLKGNARALatvtaiidgtgsIG--AA 361
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 256219564 302 VGGFLAGLPFStiakhYSWSTAFWVaeVICAASTAAFFLLR 342
Cdd:cd17344 362 LGPLLAGLISS-----RGWNNVFYM--LIAADVCAGLLLTR 395
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
177-342 |
5.55e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 38.33 E-value: 5.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 177 FLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGnpRHGLLLFMMAGMTVSMYLFRVtvtsdSPKL 256
Cdd:cd17325 21 LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDR---------FG--RKRLLLLGLLLLAVSTLLFAF-----ATSY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 257 WILVLGAV---FGFSSYGPIALfGVIAnESAPPNLCGTSHAIVGlMANVGGFLAGLPFS-TIAKHYSWSTAFWVAEVICA 332
Cdd:cd17325 85 WQLLLARFlqgLASAAVWPAAM-ALIA-DIAPPEERGRAMGIFS-SAIGLGFLIGPLLGgLLADALGYRAPFLVCAALAL 161
|
170
....*....|
gi 256219564 333 ASTAAFFLLR 342
Cdd:cd17325 162 LALVLALLLL 171
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
79-342 |
7.34e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 38.37 E-value: 7.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 79 GPILATILAQSY------SWRSTLALSGALCVVVSFLCLLLihnepadvgLRNLDPMPSEGKKGSLKEES--------TL 144
Cdd:PRK08633 155 GTALFSFLFESVngntpsEILGRIAPAGLVLLAVAVLGLIF---------AYRLPKVPAAAPEVFDKKKYlfpkllwrNL 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 145 QELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGL-VGSIAAGYLSDRAMAkaglsny 223
Cdd:PRK08633 226 KLLRSDRVLWLAIIGLSYFWFISQLAQANFPAYAKEVLGLDNTFQVQYLLAASAIGIgIGSLLAGRLSGRHIE------- 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 224 gnprHGLLLFMMAGMTVSMYLFrvtVTSDSPkLWILVLGAVFGFSSygpiALFGVIANE----SAPPNLCGTSHAIVGLM 299
Cdd:PRK08633 299 ----LGLVPLGALGLALSLFLL---PTAPSL-ASVLVLFFLFGFSA----GLFIVPLNAliqfRAPEKELGKVLAANNFL 366
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 256219564 300 ANVGGFLAgLPFSTIAKHYSWSTA--FWVAEVICAASTAA------FFLLR 342
Cdd:PRK08633 367 QNVGMLLF-LALTTLFSGLGLSPAglFYLIALVTLIGTLYtllllpDSLLR 416
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
1-114 |
7.48e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 37.98 E-value: 7.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 1 MSARWLFSSGLLLVGLVNIF---FAWSSTVPVFAaLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTwwaiLSTSMNLAGG 77
Cdd:cd17318 83 YGAKRVLGYSILITALLTLLtplAARGGYGALIV-LRILQGLAQGVTFPAMHALWAKWAPPLERSR----LTSIAYSGSQ 157
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 256219564 78 LGPI----LATILAQSYSWRSTLALSGALCVVVSFLCLLLI 114
Cdd:cd17318 158 FGTViampLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV 198
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
4-340 |
8.39e-03 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 37.68 E-value: 8.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 4 RWLFSSGLLLVGLVNIFFAWSS------TVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSmnlaGG 77
Cdd:cd17342 93 RLVLAFGMCSSAITVFLFGVLTewlhfyNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVLGLWSAC----AS 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 78 LGPILATILAQSyswrsTLALSGALCVVVSFLCLLLIhnepADVGLRNLDPMPSEGKKGSLKeestlqelllspYLWVLS 157
Cdd:cd17342 169 VGNIIGALLASS-----VLDYGYEYAFLVTSSLLFAG----AIVVFFGLLSSPPGVIPYSLA------------YACLKL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 158 TGYLVVFgvktcctdWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRaMAKaglsnygnpRHGLLLFMMAG 237
Cdd:cd17342 228 VNYSFFF--------WLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDR-MGS---------RSPVVVVMLLL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 238 MTVSMYLFRvtvTSDSPKLWILVLGAVFGFSSYGPIALF--GVIANESAPPNLCGTSHAivglMANVGGFLAG------- 308
Cdd:cd17342 290 AIPSLFVYS---HSPSDKVLNAFVMTITGFFIGGPANLIssAISADLGRQPQLRGSSEA----LATVTGIIDGtgsigaa 362
|
330 340 350
....*....|....*....|....*....|....*
gi 256219564 309 ---LPFSTIAKHYSWSTAFWVAeVICAASTAAFFL 340
Cdd:cd17342 363 igqVLVPLIQNRLGWMWVFYFF-IIMTILTIVCIL 396
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
183-337 |
8.50e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 37.94 E-value: 8.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219564 183 GQSALVGSSYMsaleVGGLVGSIAAGYLSDRamakaglsnYGnpRHGLLLFMMAGMTVSmylfrVTVTSDSPKLWILVLG 262
Cdd:cd17504 31 AAVSWVLTAYL----LVGAVSTPILGRLGDL---------YG--RKKVLLIVLAIYTAG-----SLLAAFAPNLPVLIAG 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 256219564 263 AVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMaNVGGFLAGLPF-STIAKHYSWSTAFWVAEVICAASTAA 337
Cdd:cd17504 91 RALQGIGGAVFPLAFALVREEFPPERVPVAQGILSAT-FGIGAGIGLPLgGWIVQHLGWRWIFWTAAPVAVLLAAL 165
|
|
| |
