|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-866 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1556.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 1 MHEQYQPRDIEVAAQQKWEKTAAFKAVEDASRPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWD 80
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 81 AFGMPAENAALKNQVAPAAWTYSNIEYMKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGVVNWDP 160
Cdd:COG0495 81 AFGLPAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 161 VDQTVLANEQVIDGRGWRSGALVEKREIPMYYFGITQYADELLADLDTLD-WPPQVATMQRNWIGKSFGADVRFAYDeas 239
Cdd:COG0495 161 VDQTVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDgWPEKVKTMQRNWIGRSEGAEVDFPVE--- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 240 iGSAGELTVYTTRPDTLMGATYVAVAAEHPLATQAAA--NDPALQAFIAKCKAGSVAEADMATMEKEGMPTGLFVVHPLT 317
Cdd:COG0495 238 -GSDEKITVFTTRPDTLFGATFMVLAPEHPLVKELATpeQNAAVAAFIEEAKKKSEIERTSETKEKTGVFTGLYAINPLT 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 318 GAKLPVWVANYVLMSYGSGAVMAVPAHDERDFAFANKYALPIQQVIALKEGDatfDASTWQDWYatkDDSTRLVNSGKYD 397
Cdd:COG0495 317 GEKIPIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGD---DPDILEEAY---TGDGVLINSGEFD 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 398 GLDFQGAFDAIVADLAAKAAGEKKTQYRLRDWGISRQRYWGCPIPIIHCDSCGDVPVPADQLPVVLPENVVPDGSG-NPL 476
Cdd:COG0495 391 GLDSEEAKEAIIEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDPTGgSPL 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 477 AKMPEFYETTCPCCGKPARRETDTMDTFVESSWYFARYASPDCATGMVD-DRARYWLNVDQYIGGIEHAILHLLYARFFN 555
Cdd:COG0495 471 ARAPEWVNVTCPKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDpEAANYWLPVDQYIGGIEHAILHLLYARFFT 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 556 KLMRDEGLLANDEPFQRLLTQGMVvcetfyrdldngskewitpadVVIERDGkgkiiaathkadglpVVVGGIEKMSKSK 635
Cdd:COG0495 551 KVLRDLGLVSFDEPFKRLLTQGMV---------------------LEVGKDG---------------VVIGGIEKMSKSK 594
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 636 NNGVDPQALIEQYGADTARLFMMFAAPPSQSLEWSDAGVEGAYRFLKRLYKIVSEYVAGGvaeRFVAGELTADEKALRLK 715
Cdd:COG0495 595 GNVVDPDEIIEKYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEAEAL---KLDVADLSEADKELRRA 671
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 716 LHTTIQKVSDDFGvRQQFNTAIAAVMELLN----LFDRTEASRAVRQEVLESVVVLLSPIVPHICETLWSALKPGSELLA 791
Cdd:COG0495 672 LHKTIKKVTEDIE-RLRFNTAIAALMELVNalykAKDSGEADRAVLREALETLVLLLAPFAPHIAEELWERLGHEGSVAD 750
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254782503 792 QRWPEVDPAALVQDEIELVVQVNGKLRGSVRVAADAGRDVIEAAALAHEQVRKFMDGQPAKKVIVVPGRLVNIVV 866
Cdd:COG0495 751 APWPEADEAALVEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKFLEGKTIRKVIVVPGKLVNIVV 825
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
5-866 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1196.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 5 YQPRDIEVAAQQKWEKTAAFKAVEDASRPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGM 84
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 85 PAENAALKNQVAPAAWTYSNIEYMKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGVVNWDPVDQT 164
Cdd:TIGR00396 81 PAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 165 VLANEQVI-DGRGWRSGALVEKREIPMYYFGITQYADELLADLDTLD-WPPQVATMQRNWIGKSFGADVRFAYDeasiGS 242
Cdd:TIGR00396 161 VLANEQVDsDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDhWPESVKEMQRNWIGKSEGVEITFKIA----DH 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 243 AGELTVYTTRPDTLMGATYVAVAAEHPLATQAAANDPALQAFIAKCKAGSVAEADMATMEKEGMPTGLFVVHPLTGAKLP 322
Cdd:TIGR00396 237 DEKITVFTTRPDTIFGVTYLALAPEHPLVEKAAENNPKVAAFIKKILNKTVAERTKATKEKKGVDTGIKAIHPLTGEKIP 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 323 VWVANYVLMSYGSGAVMAVPAHDERDFAFANKYALPIQQVIALKEGDATFDASTWQDwyatkddsTRLVNSGKYDGLDFQ 402
Cdd:TIGR00396 317 IWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDLSLTAAYTED--------GVLVNSGEFNGLNSS 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 403 GAFDAIVADLAAKAAGEKKTQYRLRDWGISRQRYWGCPIPIIHCDSCGDVPVPADQLPVVLPENVVPDGSG-NPLAKMPE 481
Cdd:TIGR00396 389 EARNAIIDMLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDGgSPLSRIPE 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 482 FYETTCPCCGKPARRETDTMDTFVESSWYFARYASPDCATGMVD-DRARYWLNVDQYIGGIEHAILHLLYARFFNKLMRD 560
Cdd:TIGR00396 469 WVNVTCPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDkEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRD 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 561 EGLLANDEPFQRLLTQGMVvceTFYRDLDNGSkewiTPADVVIERDGKGKIiaathkADGLPVVVGGIEKMSKSKNNGVD 640
Cdd:TIGR00396 549 IGYVNTKEPFKKLINQGMV---LGFYYPPNGK----VPADVLTERDEKGKD------KAGGELVYVGYEKMSKSKGNGID 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 641 PQALIEQYGADTARLFMMFAAPPSQSLEWSDAGVEGAYRFLKRLYKIVSEYVAGGVAERFVAGELTADEKALRLKLHTTI 720
Cdd:TIGR00396 616 PQEIVESYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEITGELDAASLTVTALEEAQKELRRDVHKFL 695
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 721 QKVSDDFGVRQQFNTAIAAVMELLNLFDRTEaSRAVRQEVLESVVVLLSPIVPHICETLWSALKPG-SELLAQRWPEVDP 799
Cdd:TIGR00396 696 KKVTEDLEKRESFNTAISAMMELLNKLYKAK-KEALMLEYLKGFVTVLSPFAPHLAEELWEKLGSEpFIIDNAKWPVVDE 774
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254782503 800 AALVQDEIELVVQVNGKLRGSVRVAADAGRDVIEAAALAHEQVRKFMDGQPAKKVIVVPGRLVNIVV 866
Cdd:TIGR00396 775 TALVEDKTLIVVQVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVI 841
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
9-866 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 830.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 9 DIEVAAQQKWEKTAAFKAVE--DASRPKYYCLSMFPYPSGK-LHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMP 85
Cdd:PLN02563 84 EIEPKWQRYWEENRTFRTPDdvDTSKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLP 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 86 AENAALKNQVAPAAWTYSNIEYMKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGVVNWDPVDQTV 165
Cdd:PLN02563 164 AEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTV 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 166 LANEQVIDGRGWRSGALVEKREIPMYYFGITQYADELLADLDTLDWPPQVATMQRNWIGKSFGADVRFAYDEASIGSAGE 245
Cdd:PLN02563 244 LANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLDWPESIKEMQRNWIGRSEGAELDFSVLDGEGKERDE 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 246 -LTVYTTRPDTLMGATYVAVAAEHPLATQAAAND--PALQAFIAKCKAGSVAEADMATMEKEGMPTGLFVVHPLTGAKLP 322
Cdd:PLN02563 324 kITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEqkEAVEEYVDAASRKSDLERTELQKEKTGVFTGSYAINPATGEAIP 403
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 323 VWVANYVLMSYGSGAVMAVPAHDERDFAFANKYALPIQQVIALKEGDATfdastwqDWYATKDDSTRLVNSGkYDGLDFQ 402
Cdd:PLN02563 404 IWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGNED-------DAEKAYTGEGVIVNSS-SSGLDIN 475
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 403 G-----AFDAIVADLAAKAAGEKKTQYRLRDWGISRQRYWGCPIPIIHCDSCGD-VPVPADQLPVVLPE--NVVPDGSGN 474
Cdd:PLN02563 476 GlsskeAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDSGEpVPVPESDLPLTLPEldDFTPTGTGE 555
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 475 -PLAKMPEFYETTCPCCGKPARRETDTMDTFVESSWYFARYASPDCATGMVD-DRARYWLNVDQYIGGIEHAILHLLYAR 552
Cdd:PLN02563 556 pPLAKAVSWVNTVDPSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDkEKEKYWMPVDLYVGGAEHAVLHLLYAR 635
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 553 FFNKLMRDEGLLANDEPFQRLLTQGMVVCETFYRDLDNGSKEWITPADVVIERDGKGKIIAA---THKADGLPV------ 623
Cdd:PLN02563 636 FWHKVLYDIGVVSTKEPFQCLVNQGMILGEVEYTAFKDSDGEYVSADTADRLGELQQEKIPEekvIKSGDSFVLkddpsi 715
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 624 -VVGGIEKMSKSKNNGVDPQALIEQYGADTARLFMMFAAPPSQSLEWSDAGVEGAYRFLKRLYKIVSEYVA--GGVAERF 700
Cdd:PLN02563 716 rLIARAHKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLVVGAPLpdGSFRDGT 795
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 701 VAGELTADEKALRLkLHTTIQKVSDDF-GVRqqFNTAIAAVMELLNLFDRTEasrAVRQEVLESVVVLLSPIVPHICETL 779
Cdd:PLN02563 796 VVTDEEPSLEQLRL-LHKCIAKVTEEIeSTR--FNTAISAMMEFTNAAYKWD---KVPREAIEPFVLLLSPYAPHLAEEL 869
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 780 WSALKPGSELLAQRWPEVDPAALVQDEIELVVQVNGKLRGSVRVAADAGRDVIEAAALAHEQVRKFMDGQPAKKVIVVPG 859
Cdd:PLN02563 870 WFRLGHSNSLAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKLSKYLDGKEIKKRIYVPG 949
|
....*..
gi 254782503 860 RLVNIVV 866
Cdd:PLN02563 950 KILNVIL 956
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
1-818 |
3.44e-101 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 333.95 E-value: 3.44e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 1 MHEQYQPRDIEVAAQQKWEKTAAFKAVEDASRPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWD 80
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 81 AFGMPAEN-----AALKNQVAPAA-----------WTYSNIEYMKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLF 144
Cdd:TIGR00422 81 HAGIATQVkvekkLGAEGKTKHDLgreefrekiweWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 145 EKGVIYRKNGVVNWDPVDQTVLANEQVIdgrgwrsgalVEKREIPMYYFgitqyaDELLADldtldwppqvatmqrnwig 224
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIEVE----------YKEVKGKLYYI------RYPLAN------------------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 225 ksfgadvrfaydeasiGSAGELTVYTTRPDTLMGATYVAVaaeHPlatqaaaNDPALQAFIAKckagsvaeadmatmeke 304
Cdd:TIGR00422 206 ----------------GSKDYLVVATTRPETMFGDTAVAV---HP-------EDERYKHLIGK----------------- 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 305 gmptglFVVHPLTGAKLPVWVANYVLMSYGSGAVMAVPAHDERDFAFANKYALPIQQVIalkegdaTFDASTWQdwyatk 384
Cdd:TIGR00422 243 ------KVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINIL-------DEDGLLNE------ 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 385 ddstrlvNSGKYDGLDFQGAFDAIVADLAAKAAGEK-------------------------------------------- 420
Cdd:TIGR00422 304 -------NAGKYQGLTRFEARKKIVEDLKEEGLLVKiephthnvgtcwrsgtvvepllskqwfvkvekladkaleaaeeg 376
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 421 ---------KTQYR-----LRDWGISRQRYWGCPIPIIHCDSCGDVPVPADQLPVVLPENVVPDgsgnplakmpefyett 486
Cdd:TIGR00422 377 eikfvpkrmEKRYLnwlrnIKDWCISRQLIWGHRIPVWYCKECGEVYVAKEEPLPDDKTNTGPS---------------- 440
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 487 cpccgKPARRETDTMDTFVESS-WYFARYASPDcatgmVDDRARYWLNVDQYIGGieHAILHLLYARFFNKLMRDEGLLa 565
Cdd:TIGR00422 441 -----VELEQDTDVLDTWFSSSlWPFSTLGWPD-----ETKDLKKFYPTDLLVTG--YDIIFFWVARMIFRSLALTGQV- 507
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 566 ndePFQRLLTQGMVvcetfyrdldngskewitpadvvieRDGKGKiiaathkadglpvvvggieKMSKSKNNGVDPQALI 645
Cdd:TIGR00422 508 ---PFKEVYIHGLV-------------------------RDEQGR-------------------KMSKSLGNVIDPLDVI 540
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 646 EQYGADTARLFMMFAAPPSQSLEWSDAGVEGAYRFLKRLYKivseyvaggvAERFV------AGELTADEKALRL----- 714
Cdd:TIGR00422 541 EKYGADALRFTLASLVTPGDDINFDWKRVESARNFLNKLWN----------ASRFVlmnlsdDLELSGGEEKLSLadrwi 610
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 715 --KLHTTIQKVSDDFGvRQQFNTAIAAVMELL-NLF--------------DRTEASRAVRQE---VLESVVVLLSPIVPH 774
Cdd:TIGR00422 611 lsKLNRTIKEVRKALD-KYRFAEAAKALYEFIwNDFcdwyielvkyrlynGNEAEKKAARDTlyyVLDKALRLLHPFMPF 689
|
890 900 910 920
....*....|....*....|....*....|....*....|....*...
gi 254782503 775 ICETLWSALKPGSELLAQR-WPEVDPAALVQD---EIELVVQVNGKLR 818
Cdd:TIGR00422 690 ITEEIWQHFKEGADSIMLQsYPVVDAEFVDEEaekAFELLKEIIVSIR 737
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
220-413 |
1.02e-96 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 300.23 E-value: 1.02e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 220 RNWIGKSFGADVRFAYDeasiGSAGELTVYTTRPDTLMGATYVAVAAEHPLATQAAANDPALQAFIAKCKAGSVAEADMA 299
Cdd:pfam13603 1 RNWIGRSEGAEITFPVE----GTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLAEKNPEVAAFIEECKNTSEIERTSE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 300 TMEKEGMPTGLFVVHPLTGAKLPVWVANYVLMSYGSGAVMAVPAHDERDFAFANKYALPIQQVIALKEGDATFDasTWQD 379
Cdd:pfam13603 77 TKEKEGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEDGDLDLD--IMTE 154
|
170 180 190
....*....|....*....|....*....|....
gi 254782503 380 WYatkDDSTRLVNSGKYDGLDFQGAFDAIVADLA 413
Cdd:pfam13603 155 AY---TEEGILVNSGEFDGLDSEEAKEAIIKKLE 185
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
34-224 |
9.17e-80 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 260.26 E-value: 9.17e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 34 KYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAENAALKNQVAPAAWTYSNIEYMKTQLK 113
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 114 SLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGVVNWDpvdqtvlaneqvidgrgwrsgalvekREIPMYYF 193
Cdd:cd00812 81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWFL 134
|
170 180 190
....*....|....*....|....*....|....
gi 254782503 194 GI--TQYADELLADLDTLD-WPPQVATMQRNWIG 224
Cdd:cd00812 135 KYseTEWKEKLLKDLEKLDgWPEEVRAMQENWIG 168
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
3-857 |
1.55e-79 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 273.61 E-value: 1.55e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 3 EQYQPRDIEVAAQQKWEKTAAFKAVEDASRPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAF 82
Cdd:PRK13208 8 KKYDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDDN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 83 GMPAE------NAALKNQVAPA-------AWTYSNIEYMKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVI 149
Cdd:PRK13208 88 GLPTErkvekyYGIRKDDISREefielcrELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKGLI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 150 YRKNGVVNWDPVDQTVLANeqvidgrgwrsgALVEKREIPMYYfgitqyadelladldtldwppqvatmqrnwigksfgA 229
Cdd:PRK13208 168 YRAEAPVLWCPRCETAIAQ------------AEVEYREREGKL------------------------------------N 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 230 DVRFaydeaSIGSAGELTVYTTRPDtLMGATyVAVAAeHPlatqaaaNDPALQAFIakckagsvaeadmatmekegmptG 309
Cdd:PRK13208 200 YIKF-----PVEDGEEIEIATTRPE-LLPAC-VAVVV-HP-------DDERYKHLV-----------------------G 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 310 LFVVHPLTGAKLPVWVANYVLMSYGSGAVMAVPAHDERDFAFANKYALPIQQVIalkegdatfdastwqdwyatkDDSTR 389
Cdd:PRK13208 242 KTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIII---------------------DEDGR 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 390 LV-NSGKYDGLDFQGAFDAIVADLaaKAAG-----EKKTQ---------------------------------------- 423
Cdd:PRK13208 301 MTeAAGKLAGLTIEEARKKIVEDL--KSGGllgkqEPIKHnvkfcercdtpleilvtrqwfikvldlkeellergkeinw 378
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 424 ----YRLR----------DWGISRQRYWGCPIPIIHCDSCGDVPVPAD-QLPVVlpenvvpdgsgnPLAKMPEFYetTCP 488
Cdd:PRK13208 379 ypehMRVRlenwieglnwDWCISRQRYFGTPIPVWYCKDCGHPILPDEeDLPVD------------PTKDEPPGY--KCP 444
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 489 CCG----KParrETDTMDTFVESSwyfaryASPdcatgmvddrarywlnvdQYIGGIEhailhllyarffnklmRDEGLL 564
Cdd:PRK13208 445 QCGspgfEG---ETDVMDTWATSS------ITP------------------LIVTGWE----------------RDEDLF 481
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 565 ANDEPFQrLLTQGMVVCET--FYR----DLDNGSKEWitpADVVIerdgKGKIIAAthkaDGlpvvvggiEKMSKSKNNG 638
Cdd:PRK13208 482 EKVFPMD-LRPQGHDIIRTwlFYTilraYLLTGKLPW---KNIMI----SGMVLDP----DG--------KKMSKSKGNV 541
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 639 VDPQALIEQYGADTARLFMMFAAPPSQS-LEWSDagVEGAYRFLKRLYKIvSEYVA--GGVAERFVAGELTADEKALRLK 715
Cdd:PRK13208 542 VTPEELLEKYGADAVRYWAASARLGSDTpFDEKQ--VKIGRRLLTKLWNA-SRFVLhfSADPEPDKAEVLEPLDRWILAK 618
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 716 LHTTIQKVSDDFGvRQQFNTAIAAVMELL-NLF---------DR---------TEASRAVRQEVLESVVVLLSPIVPHIC 776
Cdd:PRK13208 619 LAKVVEKATEALE-NYDFAKALEEIESFFwHVFcddylelvkSRaygedeeeeQKSARYTLYTVLDTLLRLLAPFLPFIT 697
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 777 ETLWSALKPGSELLaQRWPEVDPAALVQD---EIELVVQVNGKLRG--------------SVRVAADAGRDVIEAA---- 835
Cdd:PRK13208 698 EEVWSWLYGGSVHR-ASWPEPDEELIDEEdeeLGELAKEILSAVRKykseaglslnaplkKVEVYGPADLELLEAAeedl 776
|
970 980
....*....|....*....|...
gi 254782503 836 -ALAHEQVRKFMDGQPAKKVIVV 857
Cdd:PRK13208 777 kAAGNIEELELVEGDPELEVEII 799
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-813 |
3.99e-64 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 231.92 E-value: 3.99e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 1 MHEQYQPRDIEVAAQQKWEKTAAFKAVEDASRPkyYCLsMFPYP--SGKLHMGHVRNYTIGDVLSRYMALKGYNVL-QP- 76
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFKPDDNSKKP--FSI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwLPg 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 77 -------------------------MGWDAFgmpaenaaLKnqvapAAW----TYSNIeyMKTQLKSLGFAIDWEREVTT 127
Cdd:PRK05729 82 tdhagiatqmvverqlaaegksrhdLGREKF--------LE-----KVWewkeESGGT--ITNQLRRLGASCDWSRERFT 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 128 CKPDYYRWEQWLFTRLFEKGVIYRKNGVVNWDPVDQTVLANEQVIDgrgwrsgalvEKREIPMYYFgitQYAdelLADld 207
Cdd:PRK05729 147 MDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEY----------KEVKGKLWHI---RYP---LAD-- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 208 tldwppqvatmqrnwigksfgadvrfaydeasigSAGELTVYTTRPDTLMGATYVAVaaeHPlatqaaaNDPALQAFIAK 287
Cdd:PRK05729 209 ----------------------------------GSDYLVVATTRPETMLGDTAVAV---NP-------EDERYKHLIGK 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 288 ckagsvaeadmatmekegmptglFVVHPLTGAKLPVwVA-NYVLMSYGSGAVMAVPAHDERDFAFANKYALPIQQVIALk 366
Cdd:PRK05729 245 -----------------------TVILPLVGREIPI-IAdEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDE- 299
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 367 egDATFDAstwqdwyatkddstrlvNSGKYDGLD-FQgAFDAIVADLA-------------------------------- 413
Cdd:PRK05729 300 --DGTINE-----------------NPGEYQGLDrFE-ARKAIVADLEelgllvkiephthsvghsdrsgvviepylsdq 359
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 414 --------AKAAGE--------------KKTqYR-----LRDWGISRQRYWGCPIPIIHCDSCGdvpvpadqlpVVLPEN 466
Cdd:PRK05729 360 wfvkmkplAKPALEavengeikfvperwEKT-YFhwmenIQDWCISRQLWWGHRIPAWYDEDGE----------VYVGRE 428
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 467 VVPDGSGNPLakmpefyettcpccgkpaRRETDTMDT-FveSS--WYFARYASPDcATgmvDDRARYwlnvdqY-----I 538
Cdd:PRK05729 429 EPEAREKALL------------------TQDEDVLDTwF--SSalWPFSTLGWPE-KT---EDLKRF------YptsvlV 478
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 539 GGieHAILHLLYAR--FFnklmrdeGL-LANDEPFQRLLTQGMVvcetfyrdldngskewitpadvvieRDGKGKiiaat 615
Cdd:PRK05729 479 TG--FDIIFFWVARmiMM-------GLhFTGQVPFKDVYIHGLV-------------------------RDEQGR----- 519
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 616 hkadglpvvvggieKMSKSKNNGVDPQALIEQYGADTARLFMMFAAPPSQSLEWSDAGVEGAYRFLKRLYKIvSEYV--- 692
Cdd:PRK05729 520 --------------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGYRNFANKLWNA-SRFVlmn 584
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 693 --AGGVAERFVAGELTADEKALRLKLHTTIQKVSDDFgvrQQFNTAIAAvMELLNLF------------------DRTEA 752
Cdd:PRK05729 585 leGADVGELPDPEELSLADRWILSRLNRTVAEVTEAL---DKYRFDEAA-RALYEFIwnefcdwylelakpvlqeAAKRA 660
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254782503 753 SRAVRQEVLESVVVLLSPIVPHICETLWSALKPGSE---LLAQRWPEVDPAALVQDE--IELVVQV 813
Cdd:PRK05729 661 TRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIeesIMLAPWPEADEAIDEAAEaeFEWLKEL 726
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
4-822 |
1.94e-63 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 229.94 E-value: 1.94e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 4 QYQPRDIEVAAQQKWEKTAAFKAVEDASRPKYyCLsMFPYP--SGKLHMGHVRNYTIGDVLSRYMALKGYNVL-QP---- 76
Cdd:COG0525 6 TYDPKEVEAKWYQYWEENGYFKADPDSDKEPF-TI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwQPgtdh 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 77 ----------------------MGWDAFgmpaenaaLKnqvapAAW----TYSNIeyMKTQLKSLGFAIDWEREVTTCKP 130
Cdd:COG0525 84 agiatqavverqlaeegksrhdLGREKF--------LE-----RVWewkeESGGT--ITNQLRRLGASCDWSRERFTMDE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 131 DYYRWEQWLFTRLFEKGVIYRKNGVVNWDPVDQTVLANEQVidgrgwrsgalvEKREIP--MYYFgitQYAdelLADldt 208
Cdd:COG0525 149 GLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEV------------EHEEVKghLWHI---RYP---LAD--- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 209 ldwppqvatmqrnwigksfgadvrfaydeasigSAGELTVYTTRPDTLMGATYVAVaaeHPlatqaaaNDPALQAFIAKc 288
Cdd:COG0525 208 ---------------------------------GSGYIVVATTRPETMLGDTAVAV---HP-------EDERYKHLIGK- 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 289 kagsvaeadmatmekegmptglFVVHPLTGAKLPVwVA-NYVLMSYGSGAVMAVPAHDERDFAFANKYALPIQQVIalke 367
Cdd:COG0525 244 ----------------------TVILPLVGREIPI-IAdEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIL---- 296
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 368 gdaTFDASTWQdwyatkddstrlvNSGKYDGLD-FQgAFDAIVADLA--------------------------------- 413
Cdd:COG0525 297 ---DEDGTINE-------------NAGKYRGLDrFE-ARKAIVADLEelgllvkvephkhsvghsdrsgtviepylsdqw 359
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 414 -------AKAAGE--------------KKTqYR-----LRDWGISRQRYWGCPIPIIHCDScGDVPVPADQlpvvlpenv 467
Cdd:COG0525 360 fvkmkplAKPAIEavedgeikfvperwEKT-YFhwmenIRDWCISRQLWWGHRIPAWYCPD-GEVYVARTE--------- 428
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 468 vpdgsgnplakmpefyETTCPCCG-KPARRETDTMDT-FveSSW-----------------YFarYASPDCATGmvddra 528
Cdd:COG0525 429 ----------------PEACAKAGsVNLTQDEDVLDTwF--SSAlwpfstlgwpektedlkYF--YPTSVLVTG------ 482
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 529 rywlnvdqyiggieHAILHLLYAR--FFnklmrdeGL-LANDEPFQRLLTQGMVvcetfyrdldngskewitpadvvieR 605
Cdd:COG0525 483 --------------FDIIFFWVARmiMM-------GLhFTGEVPFKDVYIHGLV-------------------------R 516
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 606 DGKGKiiaathkadglpvvvggieKMSKSKNNGVDPQALIEQYGADTARLFMMFAAPPSQSLEWSDAGVEGAYRFLKRLY 685
Cdd:COG0525 517 DEQGR-------------------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFDEERVEGYRNFANKLW 577
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 686 KivseyvaggvAERFV-------AGELTADEKALRL-------KLHTTIQKVSDDFGvRQQFNTAIAAVMELL------- 744
Cdd:COG0525 578 N----------ASRFVlmnlegfDPGLDPDPEELSLadrwilsRLNKTIAEVTEALE-KYRFDEAAQALYDFVwnefcdw 646
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 745 -------NLFDRTEASRAVRQ----EVLESVVVLLSPIVPHICETLWSALKPGSE---LLAQRWPEVDPAAL---VQDEI 807
Cdd:COG0525 647 ylelakpRLYGGDEAAKRETRatlvYVLEQILRLLHPFMPFITEEIWQKLPPRKEgesIMLAPWPEADEELIdeeAEAEF 726
|
970
....*....|....*
gi 254782503 808 ELVVQVNGKLRgSVR 822
Cdd:COG0525 727 EWLKEVISAIR-NIR 740
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
4-857 |
2.50e-61 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 224.57 E-value: 2.50e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 4 QYQPRDIEVAAQQKWEKTAAFKAVEDAS--RPKYYclsmF----PYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVL-QP 76
Cdd:COG0060 15 RANLPKREPEILKFWEENDIYEKSREARagRPKFV----LhdgpPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPyVP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 77 mGWDAFGMPAENAALKN---------QVAPA---------AWTYsnIEYMKTQLKSLGFAIDWEREVTTCKPDYYRWEQW 138
Cdd:COG0060 91 -GWDCHGLPIELKVEKElgikkkdieKVGIAefrekcreyALKY--VDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWW 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 139 LFTRLFEKGVIYRKNGVVNWDPVDQTVLANeqvidgrgwrsgALVEkreipmyyfgitqYADElladldtldwppqvatm 218
Cdd:COG0060 168 ALKKLYEKGLLYKGLKPVPWCPRCGTALAE------------AEVE-------------YKDV----------------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 219 qrnwigKSFGADVRFAYDEASIGSAGE---LTVYTTRPDTLMG---------ATYVAVAAEHP----LAtqaaanDPALQ 282
Cdd:COG0060 206 ------TSPSIYVKFPVKDEKALLLLEdayLVIWTTTPWTLPAnlavavhpdIDYVLVEVTGGerliLA------EALVE 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 283 AFIAKCKAGS---VAEADMATMEkegmptGLFVVHPLTGAKL-----PVWVANYVLMSYGSGAV-MAvPAHDERDFAFAN 353
Cdd:COG0060 274 AVLKELGIEDyevLATFKGAELE------GLRYEHPFYYVVGydrahPVILGDYVTTEDGTGIVhTA-PGHGEDDFEVGK 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 354 KYALPIQQVIalkEGDATFDASTwqdwyatkddstrlvnsGKYDGLDFQGAFDAIVADLAAK----AAGE---------- 419
Cdd:COG0060 347 KYGLPVLNPV---DDDGRFTEEA-----------------PLFAGLFVKDANPAIIEDLKERgallAREKithsyphcwr 406
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 420 -KK--------------TQYR---------------------------LRDWGISRQRYWGCPIPIIHCDSCGDVPVPAD 457
Cdd:COG0060 407 cKTpliyratpqwfismDKLRdraleaiekvnwipewgegrfgnmlenRPDWCISRQRYWGVPIPIWVCEDCGELHRTEE 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 458 qlpVV--LPENVVPDGSGNPLAKMP-EFY---ETTCPCCGKPARRETDTMDTFVES--SWYFAryaspdcatgmVDDRAR 529
Cdd:COG0060 487 ---VIgsVAELLEEEGADAWFELDLhRPFldeTLKCPKCGGTMRRVPDVLDVWFDSgsMHFAV-----------LENREE 552
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 530 YWLNVDQYIGGI-EHailhllyaR-FFNKLMRdEGLLANDE-PFQRLLTQGMVVcetfyrdldngskewitpadvvierD 606
Cdd:COG0060 553 LHFPADFYLEGSdQT--------RgWFYSSLL-TSTALFGRaPYKNVLTHGFVL-------------------------D 598
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 607 GKGKiiaathkadglpvvvggieKMSKSKNNGVDPQALIEQYGADTARLFMMfAAPPSQSLEWSDAGVEGAYRFLKRLYK 686
Cdd:COG0060 599 EDGR-------------------KMSKSLGNVVDPQEVIDKYGADILRLWVA-SSDYWGDLRFSDEILKEVRDVYRRLRN 658
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 687 IVseyvaggvaeRFVAGEL---TADEKALRL------------KLHTTIQKVS---DDFgvrqQFNTAIAAVMELLNL-- 746
Cdd:COG0060 659 TY----------RFLLANLddfDPAEDAVPYedlpeldrwilsRLNELIKEVTeayDNY----DFHRAYRALHNFCVEdl 724
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 747 ----FDR-------TEAS----RAVRQ---EVLESVVVLLSPIVPHICETLWSAL---KPGSELLAQrWPEVDPAAlvqd 805
Cdd:COG0060 725 snwyLDIskdrlytEAADsldrRAAQTtlyEVLETLVRLLAPILPFTAEEIWQNLpgeAEESVHLAD-WPEVDEEL---- 799
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*
gi 254782503 806 eielvvqVNGKLRGSVRVAadagRDVIEAAALAHEQVRKfmD---GQPAKKVIVV 857
Cdd:COG0060 800 -------IDEELEAKWDLV----REVRSAVLKALEAARK--EkliRQPLEAAVVL 841
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
15-670 |
3.76e-58 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 209.96 E-value: 3.76e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 15 QQKWEKTAAFKAVEDASRPK-YYCLSMFP-YPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAEN---- 88
Cdd:pfam00133 3 YEFWDEQGYFKPELEKRKGKpSFTIHDGPpNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQvvek 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 89 ---------------AALKNQVAPAAWTYSNIeyMKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIYRKN 153
Cdd:pfam00133 83 klgikekktrhkygrEEFREKCREWKMEYADE--IRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 154 GVVNWDPVDQTVLANeqvidgrgwrsgALVEKREIPmyyfgitqyadelladldtldwppqvatmqrnwigksfGADVRF 233
Cdd:pfam00133 161 KLVNWSPALNTALSN------------LEVEYKDVK--------------------------------------GPSIHV 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 234 AYDEASiGSAGELTVYTTRPDTLMGATYVAVAAEhplaTQAAANDPALqaFIAKCKAGSVAEADmATMEKEGMPT----- 308
Cdd:pfam00133 191 AFPLAD-DEGASLVIWTTTPWTLPGNTAVAVNPE----FDYVITGEGY--ILAEALLKSLYKKG-TDKKILEDFRgkele 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 309 GLFVVHPLTGAKLPVWVANYVLMSYGSGAVMAVPAHDERDFAFANKYALPIQQVIalkegdatfdastwqdwyatKDDST 388
Cdd:pfam00133 263 GKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPV--------------------DDDGT 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 389 RLVNSGKYDGLDFQGAFDAIVADLAAKAAGEKKTQ----------------YRL-------------------------- 426
Cdd:pfam00133 323 FTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPfthsypfcwrsgtpiiPRAtpqwfvrmdeladqaleavekvqfvp 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 427 --------------RDWGISRQRYWGCPIPIIHCDSCGDVpVPADQLPVVLPENVVPDGSGNPLAKmpeFYETTCPCCGK 492
Cdd:pfam00133 403 ksgekryfnwlaniQDWCISRQRWWGHPIPAWVSKDTEEV-VCRGELFELVAGRFEEEGSIKWLHR---EAKDKLGYGKG 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 493 PARRETDTMDTFVES-SWYFARYASPDCATGMVDDRarywLNVDQYIGGIEHailhllyARF-FNKLMRDEGLLANDEPF 570
Cdd:pfam00133 479 TLEQDEDVLDTWFSSgSWPFSTLGWPFVNTEEFKKF----FPADMLLEGSDQ-------TRGwFYRMIMLSTALTGSVPF 547
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 571 QRLLTQGMVvcetfyrdldngskewitpadvvieRDGKGKiiaathkadglpvvvggieKMSKSKNNGVDPQALIEQYGA 650
Cdd:pfam00133 548 KNVLVHGLV-------------------------RDEQGR-------------------KMSKSLGNVIDPLDVIDKYGA 583
|
730 740
....*....|....*....|
gi 254782503 651 DTARLFMMFaAPPSQSLEWS 670
Cdd:pfam00133 584 DALRLWLAN-SDYGRDINLS 602
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
3-844 |
3.42e-52 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 196.83 E-value: 3.42e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 3 EQYQPRDIEVAAQQKWEKTAAFKAVEDAS--RPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWD 80
Cdd:TIGR00392 4 MRGNLSKREEKILAFWQENDIFEKVKKLNkgKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 81 AFGMPAENAALK-------NQVAPA------------AWTYsnIEYMKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFT 141
Cdd:TIGR00392 84 THGLPIEHKVEKklgisgkKEISSLeieefrekcrefALKQ--IEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 142 RLFEKGVIYRKNGVVNWDPVDQTVLANEQVidgrgwrsgalvekrEIPMYYfgitqyadelladldtldwppqvatmqrn 221
Cdd:TIGR00392 162 EAHEKGLLYRGLKPVYWSPRCRTALAEAEV---------------EYKENY----------------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 222 WIGKSFGADVRF----AYDEASIGSAGELTVYTTRPDTLMGATYVAVaaeHPLATQAAANDPAL-QAFI-AKCKAGSVAE 295
Cdd:TIGR00392 198 KDVKDPSIYVKFpvkkDKKTYLKVKLSSLLIWTTTPWTLPSNLAIAV---HPDFEYALVQDNTKvEYFIlAKKLVEKLYN 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 296 ADMATMEKegMPT-------GLFVVHPLTG-------AKLPVWVANYVLMSYGSGAVMAVPAHDERDFAFANKYALPIqq 361
Cdd:TIGR00392 275 KAGSDYEI--IKTfkgsdleGLEYEHPLYDfvsqlkeGAPVVIGGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEV-- 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 362 VIALKE-GDATFDASTWQDWYAtkddstrlvnsgKYDGLDFQGAFDAIVADLAAK----AAGE----------------- 419
Cdd:TIGR00392 351 LSPVDEkGVYTEGVNDFQGRFV------------KDADKDIIKANKIIIEQLKDKglllKAEKithsyphcwrtktpviy 418
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 420 ---------------------KKTQY-------RL-------RDWGISRQRYWGCPIPIIHCDSCGDVPVpadqlpvvlp 464
Cdd:TIGR00392 419 rateqwfiktkdikdqmleqiKKVNWvpewgegRFgnwlenrPDWCISRQRYWGIPIPIWYCEDTGEPIV---------- 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 465 envvpDGSGNPLAKMPEFYE----------------TTCPCCGKPARRETDTMDTFVES--SWyfarYASPDCATGMVDD 526
Cdd:TIGR00392 489 -----VGSIEELIELIELKGidawfedlhrdfldkiTLKSGDGGEYRRVPDVLDVWFDSgsMP----YASIHYPFENEKF 559
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 527 RARYWLNV-----DQYIGgiehailhllyarFFNKLMRDEGLLANDEPFQRLLTQGMVVcetfyrdldngskewitpadv 601
Cdd:TIGR00392 560 KEVFPADFilegsDQTRG-------------WFYSSLAIGTALFGQAPYKNVITHGFTL--------------------- 605
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 602 vierDGKGkiiaathkadglpvvvggiEKMSKSKNNGVDPQALIEQYGADTARLFMMFAApPSQSLEWSDAGVEGAYRFL 681
Cdd:TIGR00392 606 ----DEKG-------------------RKMSKSLGNVVDPLKVINKYGADILRLYVASSD-PWEDLRFSDEILKQVVEKY 661
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 682 KR-LYKIVSEYVAGGVAERFVAGE-LTADEKALRL------KLHTTIQKVSDDFGVrQQFNTAIAAVMELLNLF------ 747
Cdd:TIGR00392 662 RKiRWNTYRFLLTYANLDKFDPLFnSVAVEKFPEEdrwilsRLNSLVEEVNEALEK-YNFHKVLRALQDFIVEElsnwyi 740
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 748 ----DRTEASR---------AVRQEVLESVVVLLSPIVPHICETLWSALKPGSE---LLAQRWPEVDpAALVQDEIELVV 811
Cdd:TIGR00392 741 riirDRLYCEAkdndkraaqTTLYYALLTLVRLLAPFLPHTAEEIYQNLPGGEEeesVHLNLWPEVD-EEFIDEALEANM 819
|
970 980 990
....*....|....*....|....*....|...
gi 254782503 812 QVNGKLRGSVRVAADAGRDVIEaAALAHEQVRK 844
Cdd:TIGR00392 820 AIVREIVEAFLALRDAANKKLR-QPLKELVIGK 851
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
426-669 |
1.42e-50 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 180.52 E-value: 1.42e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 426 LRDW-GISRQRYWGCPIPIihcdscgdvpvpadqlpvvlpenvvpdgsgnplakmpefyettcpccgkparreTDTMDTF 504
Cdd:cd00812 163 QENWiGCSRQRYWGTPIPW------------------------------------------------------TDTMESL 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 505 VESSWYFARYASP-----DCATGMVDDR--ARYWLNVDQYIGGIEHAILHLLYARFFNKLMRDEGLLAnDEPFQRLLTQG 577
Cdd:cd00812 189 SDSTWYYARYTDAhnleqPYEGDLEFDReeFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLVT-DEPPKGLIVQG 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 578 MVVCETfyrdldngskewitpadvvierdgkgkiiaathkadglpvvvggiEKMSKSKNNGVDPQALIEQYGADTARLFM 657
Cdd:cd00812 268 MVLLEG---------------------------------------------EKMSKSKGNVVTPDEAIKKYGADAARLYI 302
|
250
....*....|..
gi 254782503 658 MFAAPPSQSLEW 669
Cdd:cd00812 303 LFAAPPDADFDW 314
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
48-809 |
1.59e-49 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 188.92 E-value: 1.59e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 48 LHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMP----AEnaALKNQVAPAAWTYSNI------------------ 105
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAE--RIARGDPETIELYKSLygipeeelekfkdpeyiv 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 106 EY----MKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGVVNWDPVDQTVLANEQVIDGrgwrsga 181
Cdd:PRK12300 79 EYfseeAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDG------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 182 lVEKreipmyyfGITQYadelladldTLdwppqvatmqrnwigksfgadVRFA-YDEASIGSAgeltvyTTRPDTLMGAT 260
Cdd:PRK12300 152 -EEP--------EIVEY---------TL---------------------IKFEeSEDLILPAA------TLRPETIFGVT 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 261 YVAVaaeHPLATQAAANDPALQAFIAKCKAGSVAEADMaTMEKEG-MP----TGLFVVHPLTGAKLPVWVANYVLMSYGS 335
Cdd:PRK12300 187 NLWV---NPDATYVKAEVDGEKWIVSKEAAEKLSFQDR-DVEIIEeIKgselIGKKVKNPVTGKEVPILPADFVDPDNGT 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 336 GAVMAVPAHDERDFA-----FANKYALPIQQVIAL--KEGDATFDASTWQDWYATKD-------DSTRLV---------- 391
Cdd:PRK12300 263 GVVMSVPAHAPYDYValrdlKKNKELLDVIEPIPLieVEGYGEFPAKEVVEKLGIKSqedpeleEATKEVyraefhkgvl 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 392 --NSGKYDGLDFQGAFDAIVADLAAKAAGEK----------------------KTQ------------------------ 423
Cdd:PRK12300 343 keNTGEYAGKPVREAREKITKDLIEKGIADImyefsnrpvycrcgtecvvkvvKDQwfidysdpewkelahkaldnmeii 422
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 424 ---YR---------LRDWGISRQRYWGCPIP-----IIhcDSCGDV-----------PVPADQLPvvlPENVVPD----- 470
Cdd:PRK12300 423 peeYRkefentidwLKDRACARRRGLGTRLPwdeewII--ESLSDStiymayytiahKIREYGIK---PEQLTPEffdyv 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 471 --GSGNP--LAK----MPEFYETtcpccgkpARREtdtmdtfvesswyFaryaspdcatgmvddraRYWLNVDQYIGGIE 542
Cdd:PRK12300 498 flGKGDPeeVSKktgiPKEILEE--------MREE-------------F-----------------LYWYPVDWRHSGKD 539
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 543 HAILHLLyarFFnkLMRDEGLlandepFQR-LLTQGMVVcetfyrdldNGskeWITpadvvieRDGKgkiiaathkadgl 621
Cdd:PRK12300 540 LIPNHLT---FF--IFNHVAI------FPEeKWPRGIVV---------NG---FVL-------LEGK------------- 576
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 622 pvvvggieKMSKSKNNgVDP--QAlIEQYGADTARLFMMFAAPPSQSLEWSDAGVEGAYRFLKRLYKIVSEyvaggVAER 699
Cdd:PRK12300 577 --------KMSKSKGN-VIPlrKA-IEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYELAKE-----LIEI 641
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 700 FVAGELTADEKALRLKLHTTIQKVS---DDFGVRQQFNTAIAAVMELLN-LFDRT-EASRAVRQEVLESVVVLLSPIVPH 774
Cdd:PRK12300 642 GGEEELRFIDKWLLSRLNRIIKETTeamESFQTRDAVQEAFYELLNDLRwYLRRVgEANNKVLREVLEIWIRLLAPFTPH 721
|
890 900 910
....*....|....*....|....*....|....*.
gi 254782503 775 ICETLWSALKpGSELLA-QRWPEVDPaALVQDEIEL 809
Cdd:PRK12300 722 LAEELWHKLG-GEGFVSlEKWPEPDE-SKIDEEAEL 755
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
669-783 |
5.51e-44 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 154.69 E-value: 5.51e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 669 WSDAGVEGAYRFLKRLYKIVSEYVAGGVAERFVAgELTADEKALRLKLHTTIQKVSDDFGvRQQFNTAIAAVMELLN--- 745
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPAAAA-ELSEEDKELRRKLHKTIKKVTEDIE-RLRFNTAIAALMELVNaly 78
|
90 100 110
....*....|....*....|....*....|....*....
gi 254782503 746 -LFDRTEASRAVRQEVLESVVVLLSPIVPHICETLWSAL 783
Cdd:cd07958 79 kYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
42-665 |
1.04e-43 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 162.80 E-value: 1.04e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 42 PYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAEN---------AALKNQVAPAA-------WTYSNI 105
Cdd:cd00817 10 PNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVvvekklgieGKTRHDLGREEflekcweWKEESG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 106 EYMKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGVVNWDPVDQTVLANEQVidgrGWRSGALVEk 185
Cdd:cd00817 90 GKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CSRSGDVIE- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 186 reiPMyyfgitqyadelladldtldwppqvatMQRNWigksfgadvrfaydeasigsageltvyttrpdtlmgatYVAVA 265
Cdd:cd00817 165 ---PL---------------------------LKPQW--------------------------------------FVKVK 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 266 aehPLAtqaaanDPALQAfiakckagsVAEADMAtmekegmptglfvvhpltgaklpvWvanyvlmsygsgavmaVPAHD 345
Cdd:cd00817 177 ---DLA------KKALEA---------VKEGDIK------------------------F----------------VPERM 198
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 346 ERdfafankyalpiqqvialkegdatfdasTWQDWyatkddstrlVNSgkydgldfqgafdaivadlaakaagekktqyr 425
Cdd:cd00817 199 EK----------------------------RYENW----------LEN-------------------------------- 208
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 426 LRDWGISRQRYWGCPIPIIHCDSCGDVPVPADQlpvvlpenvvpdgsgnPLAKMPEFYETTCPCCGKPARRETDTMDTFV 505
Cdd:cd00817 209 IRDWCISRQLWWGHRIPAWYCKDGGHWVVAREE----------------DEAIDKAAPEACVPCGGEELKQDEDVLDTWF 272
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 506 ESS-WYFARYASPDcatGMVDDRARYwlNVDQYIGGieHAILhllyaRF--FNKLMRDEgLLANDEPFQRLLTQGMVvce 582
Cdd:cd00817 273 SSSlWPFSTLGWPE---ETKDLKKFY--PTSLLVTG--HDII-----FFwvARMIMRGL-KLTGKLPFKEVYLHGLV--- 336
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 583 tfyrdldngskewitpadvvieRDGKGKiiaathkadglpvvvggieKMSKSKNNGVDPQALIEQYGADTARLFMMFAAP 662
Cdd:cd00817 337 ----------------------RDEDGR-------------------KMSKSLGNVIDPLDVIDGYGADALRFTLASAAT 375
|
...
gi 254782503 663 PSQ 665
Cdd:cd00817 376 QGR 378
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
5-836 |
1.10e-40 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 162.08 E-value: 1.10e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 5 YQPRDIEVAAQQKWEKTAAFKAVE-DASRPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFG 83
Cdd:PRK14900 19 YEHREVEARWYPFWQERGYFHGDEhDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 84 MpAENAALKNQVAPA------------------AWTYSNIEYMKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFE 145
Cdd:PRK14900 99 I-ATQMIVEKELKKTekksrhdlgreaflervwAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 146 KGVIYRKNGVVNWDPVDQTVLANEQVidgrgwrsgalvEKREipmyyfgitQYADELladldtldwppqvatmqrnWigk 225
Cdd:PRK14900 178 EGLIYREKKLINWCPDCRTALSDLEV------------EHEE---------AHQGEL-------------------W--- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 226 sfgadvRFAYDEASigSAGELTVYTTRPDTLMGATYVAVaaeHPLatqaaanDPALQAFIAKckagsvaeadmatmekeg 305
Cdd:PRK14900 215 ------SFAYPLAD--GSGEIVVATTRPETMLGDTAVAV---HPL-------DPRYMALHGK------------------ 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 306 mptglFVVHPLTGAKLPVwVANYVLM--SYGSGAVMAVPAHDERDFAFANKYALPIQQVIalkegdatfdastwqdwyat 383
Cdd:PRK14900 259 -----KVRHPITGRTFPI-VADAILVdpKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVI-------------------- 312
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 384 kDDSTRLVN-SGKYDGLDFQGAFDAIVADLA----------------------------------------AKAAGEKKT 422
Cdd:PRK14900 313 -GPDGRMTAeAGPLAGLDRFEARKEVKRLLAeqgldrgakphvlplgrcqrsatilepllsdqwyvrieplARPAIEAVE 391
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 423 QYRLR------------------DWGISRQRYWGCPIPIIHCdscgdvpvpadqlpvvlpenvvPDGSGNPLAKMPEfye 484
Cdd:PRK14900 392 QGRTRfipeqwtntymawmrnihDWCISRQLWWGHQIPAWYC----------------------PDGHVTVARETPE--- 446
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 485 tTCPCCGKPA-RRETDTMDTFVESS-WYFARYASPDCATGMvddRARYWLNVDQyiggIEHAILHLLYARffnklMRDEG 562
Cdd:PRK14900 447 -ACSTCGKAElRQDEDVLDTWFSSGlWPFSTMGWPEQTDTL---RTFYPTSVME----TGHDIIFFWVAR-----MMMMG 513
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 563 L-LANDEPFQRLLTQGMVvcetfyrdldngskewitpadvvieRDGKGkiiaathkadglpvvvggiEKMSKSKNNGVDP 641
Cdd:PRK14900 514 LhFMGEVPFRTVYLHPMV-------------------------RDEKG-------------------QKMSKTKGNVIDP 549
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 642 QALIEQYGADTARLFMMFAAPPSQSLEWSDAGVEGAYRFLKRLYKI-------VSEYVAGGVAERFVAGELtADEKAL-R 713
Cdd:PRK14900 550 LVITEQYGADALRFTLAALTAQGRDIKLAKERIEGYRAFANKLWNAsrfalmnLSGYQERGEDPARLARTP-ADRWILaR 628
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 714 LKLHTTIQKVS-DDFGVRQQFNTAIAAVM-ELLNLF-------------DRTEASRAVRQEVLESVVVLLSPIVPHICET 778
Cdd:PRK14900 629 LQRAVNETVEAlEAFRFNDAANAVYAFVWhELCDWYielakealasedpEARRSVQAVLVHCLQTSYRLLHPFMPFITEE 708
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254782503 779 LWSALK-------PGSELLAQRWPEVDPA--------ALVQDEIELVVQVNGKLRGSVRVAADAGRDVIEAAA 836
Cdd:PRK14900 709 LWHVLRaqvgasaWADSVLAAEYPRKGEAdeaaeaafRPVLGIIDAVRNIRGEMGIPWKVKLGAQAPVEIAVA 781
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
34-233 |
6.93e-31 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 123.68 E-value: 6.93e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 34 KYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAENAA-------------LKNQVAPAAW 100
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggrkkktiwiEEFREDPKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 101 TYSNIEYMKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGVV----NW----DPVDQTVLANEQVI 172
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPVriteQWffdmPKFKEKLLKALRRG 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254782503 173 DGR--GWRS--GALVEKR-------------EIPMYYFGItqYADELLADLDTLDWPPQVAtmqrnWIGKSFGADVRF 233
Cdd:cd00668 161 KIVpeHVKNrmEAWLESLldwaisrqrywgtPLPEDVFDV--WFDSGIGPLGSLGYPEEKE-----WFKDSYPADWHL 231
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-646 |
7.22e-31 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 130.90 E-value: 7.22e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 1 MHEQYQPRDIEVAAQQKWEKTAAFKAVEDASRP----KYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQP 76
Cdd:PTZ00419 24 MAASYDPKEVESGWYEWWEKSGFFKPAEDAKSLnsgkKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 77 MGWDAFGMPA----ENAALKNQvAPAAWTYSNIEYMK--------------TQLKSLGFAIDWEREVTTCkpDYYRWE-- 136
Cdd:PTZ00419 104 PGTDHAGIATqvvvEKKLMKEE-NKTRHDLGREEFLKkvwewkdkhgnnicNQLRRLGSSLDWSREVFTM--DEQRSKav 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 137 QWLFTRLFEKGVIYRKNGVVNWDPVDQTVLANEQV--IDgrgwrsgalVEK---REIPMYyfgitQYADElladldtldw 211
Cdd:PTZ00419 181 KEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVefEE---------IEKptkITIPGY-----DKKVE---------- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 212 ppqvatmqrnwigksFGADVRFAYdEASIGSAGELTVYTTRPDTLMGATYVAVaaeHPlatqaaaNDPALQAFIAKckag 291
Cdd:PTZ00419 237 ---------------VGVLWHFAY-PLEDSGQEEIVVATTRIETMLGDVAVAV---HP-------KDERYKKLHGK---- 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 292 svaeadmatmekegmptglFVVHPLT-GAKLPVwVAN--YVLMSYGSGAVMAVPAHDERDFAFANKYALPIQQVialkeg 368
Cdd:PTZ00419 287 -------------------ELIHPFIpDRKIPI-IADdeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINI------ 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 369 datFDastwqdwyatkDDSTRLVNSGKYDGLDfqgAFDA--------------------------------IV------- 409
Cdd:PTZ00419 341 ---FT-----------LDGKINENGGEFAGMH---RFDCrrkieeelkemgllrdkvpnpmrlprcsrsgdIVepmlipq 403
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 410 -----ADLAAKAA-----GEKK--------TQYR----LRDWGISRQRYWGCPIPIIHCDSCGDVPVPADQLPVVLPENv 467
Cdd:PTZ00419 404 wyvncKDMAKRAVeavrnGELKiipsshenVWYHwlenIQDWCISRQLWWGHRIPAYRVISKGPETDPSDEEPWVVARS- 482
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 468 VPDGSGNPLAKMP---EFYETTcpccgkparRETDTMDTFVESS-WYFARYASPDcatgMVDDRARYWLNVDQYIGgieH 543
Cdd:PTZ00419 483 EEEALEKAKKKFGlseEDFELE---------QDEDVLDTWFSSGlFPFSTLGWPD----QTDDLQRFFPTSLLETG---S 546
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 544 AILHLLYAR-------FFNKLmrdegllandePFQRLLTQGMVvcetfyrdldngskewitpadvvieRDGKGkiiaath 616
Cdd:PTZ00419 547 DILFFWVARmvmmslhLTDKL-----------PFKTVFLHAMV-------------------------RDSQG------- 583
|
730 740 750
....*....|....*....|....*....|
gi 254782503 617 kadglpvvvggiEKMSKSKNNGVDPQALIE 646
Cdd:PTZ00419 584 ------------EKMSKSKGNVIDPLEVIE 601
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
18-796 |
6.10e-28 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 121.20 E-value: 6.10e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 18 WEKTAAFKAVED-ASRPkyYCLSMfPYP--SGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFG---------MP 85
Cdd:PLN02943 73 WESQGYFKPNFDrGGDP--FVIPM-PPPnvTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGiatqlvvekML 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 86 AENAALKNQVAPAAWTYSNIEY-------MKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGVVNW 158
Cdd:PLN02943 150 ASEGIKRTDLGRDEFTKRVWEWkekyggtITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNW 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 159 DPVDQTVLANEQvidgrgwrsgalVEKREIP--MYYFgitQYadelladldtldwppQVATmqrnwigksfgadvrfayd 236
Cdd:PLN02943 230 SPNLQTAVSDLE------------VEYSEEPgtLYYI---KY---------------RVAG------------------- 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 237 easiGSAGELTVYTTRPDTLMGATYVAVAAEhplatqaaanDPALQAFIAKckagsvaeadMAtmekegmptglfvVHPL 316
Cdd:PLN02943 261 ----GSEDFLTIATTRPETLFGDVAIAVNPE----------DDRYSKYIGK----------MA-------------IVPM 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 317 TGAK-LPVWVANYVLMSYGSGAVMAVPAHDERDFAFANKYALPIQQVIalkEGDAT---------FDAST--WQDWYAT- 383
Cdd:PLN02943 304 TYGRhVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVM---NKDGTlnevaglywFEAREklWSDLEETg 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 384 ----KDDSTRLVNSGKYDG-----LDFQGAFdAIVADLAAKAAG--------------EKKTQYRL---RDWGISRQRYW 437
Cdd:PLN02943 381 lavkKEPHTLRVPRSQRGGeviepLVSKQWF-VTMEPLAEKALKavengeltiiperfEKIYNHWLsniKDWCISRQLWW 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 438 GCPIPI--IHCDSCGDvpvpadqlpvvlpENVVPDGSGNPLAKMPEFYettcpccGKPAR--RETDTMDTFVESS-WYFA 512
Cdd:PLN02943 460 GHRIPVwyIVGKDCEE-------------DYIVARSAEEALEKAREKY-------GKDVEiyQDPDVLDTWFSSAlWPFS 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 513 RYASPDCATgmvDDRARYWLNVDQYIGgieHAILHLLYARFFNKLMRDEGLLandePFQRLLTQGMVvcetfyrdldngs 592
Cdd:PLN02943 520 TLGWPDVSA---EDFKKFYPTTVLETG---HDILFFWVARMVMMGIEFTGTV----PFSYVYLHGLI------------- 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 593 kewitpadvvieRDGKGKiiaathkadglpvvvggieKMSKSKNNGVDPQALIEQYGADTARlFMMFAAPPSQSLEWSDA 672
Cdd:PLN02943 577 ------------RDSQGR-------------------KMSKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDLNLSTE 624
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 673 GVEGAYRFLKRLY---KIVSEYVAG----GVAERFVAGELTADEKALRL---------KLHTTIQKVSDDFGvRQQFNTA 736
Cdd:PLN02943 625 RLTSNKAFTNKLWnagKFVLQNLPSqsdtSAWEHILACKFDKEESLLSLplpecwvvsKLHELIDSVTTSYD-KYFFGDV 703
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 737 IAAVMELL--------------NLFDR-----TEASRAVRQEVLESVVVLLSPIVPHICETLWSAL-KPGSELLAQRWPE 796
Cdd:PLN02943 704 GREIYDFFwsdfadwyieasktRLYHSgdnsaLSRAQAVLLYVFENILKLLHPFMPFVTEELWQALpYRKEALIVSPWPQ 783
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
11-829 |
2.22e-27 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 119.49 E-value: 2.22e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 11 EVAAQQKWEKTAAFKAVEDASRPKYYCL-SMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAENA 89
Cdd:PLN02843 9 EPEIQKLWEENQVYKRVSDRNNGESFTLhDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 90 ALKN-------QVAP-------AAWTYSNIEYMKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGV 155
Cdd:PLN02843 89 VLQSldqearkELTPiklrakaAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 156 VNWDPVDQTVLANEQVIDGRGWRSGAlvekreipMYyfgitqyadelladldtldwppqvATMQRNWIGKSFGADVRFAY 235
Cdd:PLN02843 169 VHWSPSSRTALAEAELEYPEGHVSKS--------IY------------------------VAFPVVSPSETSPEELEEFL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 236 DEASigsageLTVYTTRPDTLMGATYVAVAAEHPLA---TQAAANDPALQAFIAKCKAGS-----------VAEADMATM 301
Cdd:PLN02843 217 PGLS------LAIWTTTPWTMPANAAVAVNDKLQYSvveVQSFSEDESTSGGNKKKRPGNvlkeqqklfliVATDLVPAL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 302 E-KEGMP------------TGLFVVHPLTGAKLPVWVA-NYVLMSYGSGAVMAVPAHDERDFAFANKYALPIQQ------ 361
Cdd:PLN02843 291 EaKWGVKlvvlktfpgsdlEGCRYIHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSpvddag 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 362 ----------------------VIALKEGDATFDASTWQ-----DWYATKDDSTRLVNS--GKYDGLDfQGAFDAIVADL 412
Cdd:PLN02843 371 kfteeagqfsglsvlgegnaavVEALDEAGSLLMEEAYGhkypyDWRTKKPTIFRATEQwfASVEGFR-QAALDAIDKVK 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 413 AAKAAGEKK----TQYRlRDWGISRQRYWGCPIPII-HCDScgDVPVPADQLPVVLPENVVPDGSgNPLAKM------PE 481
Cdd:PLN02843 450 WIPAQGENRiramVSGR-SDWCISRQRTWGVPIPVFyHVET--KEPLMNEETIAHVKSIVAQKGS-DAWWYMdvedllPE 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 482 FYETTCPccgkPARRETDTMDTFVES--SWyfaryaspdcaTGMVDDRAR-------YWLNVDQYIGGIEHAILHLLYAR 552
Cdd:PLN02843 526 KYRDKAS----DYEKGTDTMDVWFDSgsSW-----------AGVLGSREGlsypadlYLEGSDQHRGWFQSSLLTSVATK 590
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 553 ffnklmrdegllaNDEPFQRLLTQGMVVcetfyrdldngskewitpadvvierDGKGkiiaathkadglpvvvggiEKMS 632
Cdd:PLN02843 591 -------------GKAPYKSVLTHGFVL-------------------------DEKG-------------------FKMS 613
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 633 KSKNNGVDPQALIE---------QYGADTARLFMmfaappsQSLEW-SDAGVEG--------AYRFLKRLYKIVSEYVAG 694
Cdd:PLN02843 614 KSLGNVVDPRLVIEggknqkqepAYGADVLRLWV-------ASVDYtGDVLIGPqilkqmsdIYRKLRGTLRYLLGNLHD 686
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 695 GVAERFVAGE-LTADEKALRLKLHTTIQKVSDDFGvRQQFNTAIA-----AVMELLNLF-----DR------TEASRAVR 757
Cdd:PLN02843 687 WKPDNAVPYEdLPSIDKYALFQLENVVNEIEESYD-NYQFFKIFQilqrfTIVDLSNFYldvakDRlyvggtTSFTRRSC 765
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 758 QEV----LESVVVLLSPIVPHICETLWSAL------KPGSELLAQRWPEVDPAALVQDEIELVV-QVNGKLRGSVRVAAD 826
Cdd:PLN02843 766 QTVlaahLLSLLRAIAPILPHLAEDAWQNLpfqedgSAAESVFEAGWPTPNEEWLSFPAEDVDFwSLLLEVRDEVNKVLE 845
|
...
gi 254782503 827 AGR 829
Cdd:PLN02843 846 SAR 848
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-357 |
1.59e-24 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 110.37 E-value: 1.59e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 1 MHEQYQPRDIEVAAQQKWEKTAAFKAVEDASRPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWD 80
Cdd:PLN02381 96 MAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVD 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 81 AFGMPAENAALKN---------------QVAPAAWTYSNiEYMKT---QLKSLGFAIDWEREVTTCKPDYYRWEQWLFTR 142
Cdd:PLN02381 176 HAGIATQVVVEKKlmrerhltrhdigreEFVSEVWKWKD-EYGGTilnQLRRLGASLDWSRECFTMDEQRSKAVTEAFVR 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 143 LFEKGVIYRKNGVVNWDPVDQTVLANEQvidgrgwrsgalVEKREIpmyyfgitqyADELLADLDTLDWPPQvatmqrnw 222
Cdd:PLN02381 255 LYKEGLIYRDIRLVNWDCTLRTAISDVE------------VDYIDI----------KERTLLKVPGYDKPVE-------- 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 223 igksFGADVRFAYDEAsiGSAGELTVYTTRPDTLMGATYVAVaaeHPlatqaaaNDPALQAFiakckagsvaeadmatme 302
Cdd:PLN02381 305 ----FGVLTSFAYPLE--GGLGEIVVATTRIETMLGDTAIAI---HP-------DDERYKHL------------------ 350
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 254782503 303 kegmpTGLFVVHPLTGAKLPVwVANYVLM--SYGSGAVMAVPAHDERDFAFANKYAL 357
Cdd:PLN02381 351 -----HGKFAVHPFNGRKLPI-ICDAILVdpNFGTGAVKITPAHDPNDFEVGKRHNL 401
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
34-223 |
1.50e-22 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 99.53 E-value: 1.50e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 34 KYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAENAALKNQVAPAAWTYSNIEYMKTQLK 113
Cdd:cd00814 1 KVLITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 114 SLGFAIDweREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGVVNWDPVDQTVLAneqvidgrgwrsgalvEKREIPMYYF 193
Cdd:cd00814 81 WLNISFD--YFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP----------------EWREEEHYFF 142
|
170 180 190
....*....|....*....|....*....|...
gi 254782503 194 GITQYADELLADLDT---LDWPPQVATMQRNWI 223
Cdd:cd00814 143 RLSKFQDRLLEWLEKnpdFIWPENARNEVLSWL 175
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
33-223 |
9.07e-20 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 94.02 E-value: 9.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 33 PKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAENAALKNQVAPAAWTYSNIEYMKTQL 112
Cdd:COG0143 1 KKFLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKELF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 113 KSLGfaIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGVVNWDPVDQT---------------------------- 164
Cdd:COG0143 81 EKLG--ISFDNFIRTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERflpdryvegtcpkcgaedaygdqcencg 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254782503 165 -VLANEQVIDGRGWRSGALVEKREIPMYYFGITQYADELLADLDTL-DWPPQVATMQRNWI 223
Cdd:COG0143 159 aTLEPTELINPRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENpDIQPEVRNEVLSWL 219
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
35-223 |
4.53e-18 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 87.35 E-value: 4.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 35 YYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAENAALKNQVAPAAWTYSNIEYMKTQLKS 114
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 115 LGFAID-WERevtTCKPDYYRWEQWLFTRLFEKGVIYRKNGVVNWDPVDQTVLANEQVI---------DGRGWR------ 178
Cdd:pfam09334 81 FNISFDdYGR---TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVEgtcphcgseDARGDQcencgr 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254782503 179 --------------SGALVEKREIPMYYFGITQYADELLADLDT--LDWPPQVATMQRNWI 223
Cdd:pfam09334 158 hleptelinpkcviCGTTPEVKETEHYFFDLSKFQDKLREWIEEnnPEWPENVKNMVLEWL 218
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
625-797 |
5.23e-18 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 88.25 E-value: 5.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 625 VGGiEKMSKSKNNGVDPQALIEQYGADTARLFMMFAAPPSQ--SLEWSD---------AGVEG--AYRFLKRLYKivseY 691
Cdd:COG0143 323 VEG-EKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQdgDFSWEDfvarvnsdlANDLGnlASRTLSMIHK----Y 397
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 692 VAGGVAErfvAGELTADEKALRLKLHTTIQKVSDDFGvRQQFNTAIAAVMELLNL----FDRTE-------ASRAVRQEV 760
Cdd:COG0143 398 FDGKVPE---PGELTEADEELLAEAEAALEEVAEAME-AFEFRKALEEIMALARAankyIDETApwklakdEDPERLATV 473
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 254782503 761 L----ESV---VVLLSPIVPHICETLWSALkpGSELLAQRWPEV 797
Cdd:COG0143 474 LytllEALrilAILLKPFLPETAEKILEQL--GLEGDELTWEDA 515
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
42-667 |
9.66e-18 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 85.36 E-value: 9.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 42 PYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAENAALKN----------QVAPAAW-------TYSN 104
Cdd:cd00818 10 PYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKElgisgkkdieKMGIAEFnakcrefALRY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 105 IEYMKTQLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGVVNWdPVDQtvlaneqvidgrgwrsgalve 184
Cdd:cd00818 90 VDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-PLIY--------------------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 185 kREIPMYYFGITQYADELLADLDTLDWPPqvatmqrNWIGKSFGAdvrfaydeasigsageltvyttrpdtlmgatyvav 264
Cdd:cd00818 148 -RATPQWFIRVTKIKDRLLEANDKVNWIP-------EWVKNRFGN----------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 265 aaehplatqaaandpalqafiakckagsvaeadmatmekegmptglfvvhpltgaklpvWVANyvlmsygsgavmavpah 344
Cdd:cd00818 185 -----------------------------------------------------------WLEN----------------- 188
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 345 derdfafankyalpiqqvialkegdatfdastwqdwyatkddstrlvnsgkydgldfqgafdaivadlaakaagekktqy 424
Cdd:cd00818 --------------------------------------------------------------------------------
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 425 rLRDWGISRQRYWGCPIPIIHCDSCGDVPVpadqlpvvlpenvvpdgsgnplakmpefyettcpccgkpaRRETDTMDTF 504
Cdd:cd00818 189 -RRDWCISRQRYWGTPIPVWYCEDCGEVLV----------------------------------------RRVPDVLDVW 227
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 505 VES--SWYFARYASPDCATGMVDDRARYWLN-VDQYIGgiehailhllyarFFNKLMRDEGLLANDEPFQRLLTQGMVVc 581
Cdd:cd00818 228 FDSgsMPYAQLHYPFENEDFEELFPADFILEgSDQTRG-------------WFYSLLLLSTALFGKAPYKNVIVHGFVL- 293
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 582 etfyrdldngskewitpadvvierDGKGKiiaathkadglpvvvggieKMSKSKNNGVDPQALIEQYGADTARLFMMFAA 661
Cdd:cd00818 294 ------------------------DEDGR-------------------KMSKSLGNYVDPQEVVDKYGADALRLWVASSD 330
|
....*.
gi 254782503 662 PPSQSL 667
Cdd:cd00818 331 VYAEDL 336
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
709-832 |
6.05e-17 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 78.21 E-value: 6.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 709 EKALRLKLHTTIQKVSDDFGvRQQFNTAIAAVMELLN--------------LFDRTEASRAVR--QEVLESVVVLLSPIV 772
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYE-NYRFNTAAQALYEFFWndlsdwylelikdrLYGEEPDSRAQTtlYEVLETLLRLLAPFM 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254782503 773 PHICETLWSalkpGSELLAQRWPEVDPAALVQDEIEL-----VVQVNGKLRGSVRVAADAGRDVI 832
Cdd:pfam08264 80 PFITEELWQ----KESIHLAPWPEDAELEEAELEEAFelrqeIVQAIRKLRSELKIKKSLPLEVV 140
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
617-789 |
1.40e-15 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 80.70 E-value: 1.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 617 KADGLPV----------VVGGiEKMSKSKNNGVDPQALIEQYGADTARLFMMFAAPPSQSLEWSDAGVEGAYR------- 679
Cdd:PRK11893 277 MAAGLPLpkrvfahgflTLDG-EKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDGDFSREAFINRINadlandl 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 680 --FLKRLYKIVSEYVAGGVAErfvAGELTADEKALRLKLHTTIQKVSDDFGvRQQFNTAIAAVMELLN----LFDRTE-- 751
Cdd:PRK11893 356 gnLAQRTLSMIAKNFDGKVPE---PGALTEADEALLEAAAALLERVRAAMD-NLAFDKALEAILALVRaankYIDEQApw 431
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 254782503 752 ----ASRAVRQEVLESVV-------VLLSPIVPHICETLWSALKPGSEL 789
Cdd:PRK11893 432 slakTDPERLATVLYTLLevlrgiaVLLQPVMPELAAKILDQLGVEEDE 480
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
42-204 |
1.84e-15 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 80.31 E-value: 1.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 42 PYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAENAALKNQVAPAAWTYSNIEYMKTQLKSLGfaIDW 121
Cdd:PRK11893 10 YYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLWEALN--ISY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 122 EREVTTCKPDYYRWEQWLFTRLFEKGVIYRKN--GvvnWDPV-DQTVLANEQVIDGRGW--RSGALVEKREIPMYYFGIT 196
Cdd:PRK11893 88 DDFIRTTDPRHKEAVQEIFQRLLANGDIYLGKyeG---WYCVrCEEFYTESELIEDGYRcpPTGAPVEWVEEESYFFRLS 164
|
....*...
gi 254782503 197 QYADELLA 204
Cdd:PRK11893 165 KYQDKLLE 172
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
11-684 |
2.48e-12 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 70.91 E-value: 2.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 11 EVAAQQKWEKTAAFKAV--EDASRPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAEN 88
Cdd:PLN02882 14 EEKILSLWSEIDAFKTQlkRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEY 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 89 AALK------------------NQVAPAAWTYSNIEYMKTqLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIY 150
Cdd:PLN02882 94 EIDKklgikrrddvlkmgidkyNEECRSIVTRYSKEWEKT-VTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVY 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 151 RKNGVVNWDPVDQTVLANEQVidGRGWRSgalVEKREIpMYYFGITqyADELLADLdtldwppqVATMQRNWIGKSFGA- 229
Cdd:PLN02882 173 KGFKVMPYSTACKTPLSNFEA--GLNYKD---VSDPAV-MVSFPIV--GDPDNASF--------VAWTTTPWTLPSNLAl 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 230 --DVRFAYdeasigsageltVYTTRPDTlmGATYvaVAAEHPLAtqaaandpALQAFIAKCKAGSVAEADMATMEKEGMP 307
Cdd:PLN02882 237 cvNPNFTY------------VKVRNKYT--GKVY--IVAESRLS--------ALPTAKPKSKKGSKPENAAEGYEVLAKV 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 308 TGLFVV----HPL-------TGAKLPVWVANYVLMSYGSGAVMAVPAHDERDF--AFANK-----------------YAL 357
Cdd:PLN02882 293 PGSSLVgkkyEPLfdyfsefSDTAFRVVADDYVTDDSGTGVVHCAPAFGEDDYrvCLANGiiekggnlpvpvdddgcFTE 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 358 PIQQVIAL--KEGDatfdastwQDWYATKDDSTRLVNSGKYDG-------LDFQGAFDAI------VADLAAK-AAGEKK 421
Cdd:PLN02882 373 KVTDFSGRyvKDAD--------KDIIAAIKAKGRLVKSGSITHsypfcwrSDTPLIYRAVpswfvkVEEIKDRlLENNKQ 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 422 TQY--------RL-------RDWGISRQRYWGCPIPiIHCDSCGdvpvpadqlpvvlpENVVPDGSGNPLAKMPEFYET- 485
Cdd:PLN02882 445 TYWvpdyvkekRFhnwlenaRDWAVSRSRFWGTPLP-IWISDDG--------------EEVVVIGSIAELEKLSGVKVTd 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 486 ---------TCPCCGKPA----RRETDTMDTFVES-SWYFARYASP--------------DCATGMvdDRARYWlnvdqy 537
Cdd:PLN02882 510 lhrhfidhiTIPSSRGPEfgvlRRVDDVFDCWFESgSMPYAYIHYPfenkelfeknfpadFVAEGL--DQTRGW------ 581
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 538 iggiehailhllyarfFNKLMRDEGLLANDEPFQRLLTQGMVVCEtfyrdldngskewitpadvvierDGKgkiiaathk 617
Cdd:PLN02882 582 ----------------FYTLMVLSTALFDKPAFKNLICNGLVLAE-----------------------DGK--------- 613
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 618 adglpvvvggieKMSKSKNNGVDPQALIEQYGADTARLFMMfAAP--PSQSLEWSDAGVEG-----------AYRFL--- 681
Cdd:PLN02882 614 ------------KMSKSLKNYPDPNEVIDKYGADALRLYLI-NSPvvRAEPLRFKEEGVFGvvkdvflpwynAYRFLvqn 680
|
....
gi 254782503 682 -KRL 684
Cdd:PLN02882 681 aKRL 684
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
623-835 |
1.20e-10 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 64.74 E-value: 1.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 623 VVVGGiEKMSKSKNNGVDPQALIEQYGADTARLFMMfAAPPSQSLEWSDAGVEGAYRFLKRLY---KIVSEYVAGGVAER 699
Cdd:COG0215 259 LTVNG-EKMSKSLGNFFTVRDLLKKYDPEVLRFFLL-SAHYRSPLDFSEEALEEAEKALERLYnalRRLEEALGAADSSA 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 700 FVAGELTAD-EKALrlklhttiqkvSDDFGVRQqfntAIAAVMELLNLFDRTEASRAVRQEVlesvvvllspivphicET 778
Cdd:COG0215 337 EEIEELREEfIAAM-----------DDDFNTPE----ALAVLFELVREINKALDEGEDKAAL----------------AA 385
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254782503 779 LWSALKPGSELL------AQRWPEVDPAALVQDEIELVVQVngklRGSVRVA-----ADAGRDVIEAA 835
Cdd:COG0215 386 LAALLRALGGVLgllllePEAWQGAAEDELLDALIEALIEE----RAEARKAkdfarADRIRDELAAL 449
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
617-783 |
6.49e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 62.90 E-value: 6.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 617 KADGLP----VVVGGI-----EKMSKSKNNGVDPQALIEQYGADTARLFMMFAAPPSQSLEWS-DAGVEgayRF------ 680
Cdd:PRK12267 277 MALGLPlpkkVFAHGWwlmkdGKMSKSKGNVVDPEELVDRYGLDALRYYLLREVPFGSDGDFSpEALVE---RInsdlan 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 681 -----LKRLYKIVSEYVAGGVAErfvAGELTADEKALRLKLHTTIQKVSDDFGvRQQFNTAIAAVMELLNL----FDRTE 751
Cdd:PRK12267 354 dlgnlLNRTVAMINKYFDGEIPA---PGNVTEFDEELIALAEETLKNYEELME-ELQFSRALEEVWKLISRankyIDETA 429
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 254782503 752 ----ASRAVRQEVLESVV-----------VLLSPIVPHICETLWSAL 783
Cdd:PRK12267 430 pwvlAKDEGKKERLATVMyhlaeslrkvaVLLSPFMPETSKKIFEQL 476
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
43-204 |
2.20e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 60.97 E-value: 2.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 43 YPSGKLHMGHVrnYT--IGDVLSRYMALKGYNVLQPMGWDAFGMPAENAALKNQVAPAAWTYSNIEYMKTQLKSLGfaID 120
Cdd:PRK12267 14 YPNGKPHIGHA--YTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYVDEISAGFKELWKKLD--IS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 121 WEREVTTCKPDYYRWEQWLFTRLFEKGVIYrKNGVVNWDPV-DQTVLANEQVID-GRGWRSGALVEKREIPMYYFGITQY 198
Cdd:PRK12267 90 YDKFIRTTDERHKKVVQKIFEKLYEQGDIY-KGEYEGWYCVsCETFFTESQLVDgGKCPDCGREVELVKEESYFFRMSKY 168
|
....*.
gi 254782503 199 ADELLA 204
Cdd:PRK12267 169 QDRLLE 174
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
8-92 |
1.05e-08 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 59.31 E-value: 1.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 8 RDIEVAAQQKWEKTAAFKA----VEDASRPKYYclSMFPYP--SGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDA 81
Cdd:PLN02959 16 LEIEVAVQKWWEEEKVFEAeagdEPPKPGEKFF--GNFPYPymNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHC 93
|
90
....*....|.
gi 254782503 82 FGMPAENAALK 92
Cdd:PLN02959 94 TGMPIKASADK 104
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
42-223 |
1.36e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 58.62 E-value: 1.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 42 PYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAENAALKNQVAPAAWtysnIEYMKTQLKS--LGFAI 119
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITPEEL----IARYHAEHKRdfAGFGI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 120 DWEREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGVVNWDPVDQTVL-------------ANEQ---------------- 170
Cdd:PRK00133 87 SFDNYGSTHSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLpdrfvkgtcpkcgAEDQygdncevcgatyspte 166
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 254782503 171 VIDGRGWRSGALVEKREIPMYYFGITQYADELLADLDT-LDWPPQVATMQRNWI 223
Cdd:PRK00133 167 LINPKSAISGATPVLKESEHFFFKLPRFEEFLKEWITRsGELQPNVANKMKEWL 220
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
669-783 |
1.40e-08 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 53.75 E-value: 1.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 669 WSDAGVEGAYRFLKRLYKIVSEyvagGVAERFVAGELTADEKALRLKLHTTIQKVS---DDFgvrqQFNTAI-AAVMELL 744
Cdd:cd07959 1 FREEEANSAILRLERFYELAEE----LIETEGELEELTFIDRWLLSRLNRLIKETTeayENM----QFREALkEGLYELQ 72
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 254782503 745 NLFD------RTEASRAVRQEVLESVVVLLSPIVPHICETLWSAL 783
Cdd:cd07959 73 NDLDwyrergGAGMNKDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
623-669 |
1.92e-07 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 53.96 E-value: 1.92e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 254782503 623 VVVGGIEKMSKSKNNGVDPQALIEQYGADTARLFMMFAAPPSQSLEW 669
Cdd:cd00668 266 VLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
18-151 |
6.44e-07 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 53.43 E-value: 6.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 18 WEKTAAFKAVEDASRPK--YYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAE-------- 87
Cdd:PTZ00427 85 WKSIDAFNTSNKLAKNKkaYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEyeiekenn 164
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254782503 88 ---------------NAALKNQVApaawTYSNiEYMKTqLKSLGFAIDWEREVTTCKPDYYRWEQWLFTRLFEKGVIYR 151
Cdd:PTZ00427 165 inkkedilkmgidvyNEKCRGIVL----KYSN-EWVKT-VERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYK 237
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
629-665 |
9.53e-07 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 51.76 E-value: 9.53e-07
10 20 30
....*....|....*....|....*....|....*..
gi 254782503 629 EKMSKSKNNGVDPQALIEQYGADTARLFMMFAAPPSQ 665
Cdd:cd00814 279 KKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGK 315
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
674-783 |
1.59e-06 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 48.32 E-value: 1.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 674 VEGAYRFLKRLYKI---VSEYVAGGVAERFVAGELTADEKALRLKLHTTIQKVSDDFGVRQqFNTAIAAVME-LLNLF-- 747
Cdd:cd07962 6 VEGGRNFCNKLWNAarfVLMNLEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYR-FSEAATALYEfFWNDFcd 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 254782503 748 ---------------DRTEASRAVRQEVLESVVVLLSPIVPHICETLWSAL 783
Cdd:cd07962 85 wylelvkprlygedeEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
715-829 |
3.27e-06 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 48.32 E-value: 3.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 715 KLHTTIQKVS---DDFgvrqQFNTAIAAVM----ELLNLF-----DR---------TEASRAVRQEVLESVVVLLSPIVP 773
Cdd:cd07961 55 RLNSLIKEVTeemEAY----DLYTAVRALLefidELTNWYirrnrKRfwgeegdddKLAAYATLYEVLLTLSRLMAPFTP 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254782503 774 HICETLWSALKPGSELLA-----QRWPEVDpAALVQDEIELVVQVngklrgsVRVAADAGR 829
Cdd:cd07961 131 FITEEIYQNLRRELGDAPesvhlLDWPEVD-ESLIDEELEEAMEL-------VREIVELGR 183
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
629-672 |
4.89e-05 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 46.51 E-value: 4.89e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 254782503 629 EKMSKSKNNGVDPQALIEQYGADTARLFMMFAAPPSQ--SLEWSDA 672
Cdd:pfam09334 323 GKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKdtDFSWEDF 368
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
680-783 |
6.26e-05 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 43.63 E-value: 6.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 680 FLKRLYKIVSEYvAGGVAERFvaGELTADEKALRLKLHTTIQKVSDDFGvRQQFNTAIAAVMELLNL----FDRTE---- 751
Cdd:cd07957 12 LVNRTLNMASKY-FGGVVPEF--GGLTEEDEELLEEAEELLEEVAEAME-ELEFRKALEEIMELARAankyIDETApwkl 87
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 254782503 752 ---ASRAVRQEVLESVV-------VLLSPIVPHICETLWSAL 783
Cdd:cd07957 88 akeEDPERLATVLYVLLellrilaILLSPFMPETAEKILDQL 129
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
427-674 |
9.81e-05 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 46.11 E-value: 9.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 427 RDWGISRQRYWGCPIPiIHCDS------CGDVPVPADQLPVVlpENVV--------------PDGSGNP-LAKMPEFYET 485
Cdd:PTZ00427 569 KDWCISRNRYWGTPIP-IWADEkmetviCVESIKHLEELSGV--KNINdlhrhfidhieiknPKGKTYPkLKRIPEVFDC 645
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 486 TCPCCGKPARRETDTMDTFVESswyFARYASPD-CATGMvdDRARYWlnvdqyiggiehailhllyarfFNKLMRDEGLL 564
Cdd:PTZ00427 646 WFESGSMPYAKVHYPFSTEKED---FHKIFPADfIAEGL--DQTRGW----------------------FYTLLVISTLL 698
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254782503 565 ANDEPFQRLLTQGMVVCEtfyrdldngskewitpadvvierDGKgkiiaathkadglpvvvggieKMSKSKNNGVDPQAL 644
Cdd:PTZ00427 699 FDKAPFKNLICNGLVLAS-----------------------DGK---------------------KMSKRLKNYPDPLYI 734
|
250 260 270
....*....|....*....|....*....|.
gi 254782503 645 IEQYGADTARLFMMFA-APPSQSLEWSDAGV 674
Cdd:PTZ00427 735 LDKYGADSLRLYLINSvAVRAENLKFQEKGV 765
|
|
| argS |
TIGR00456 |
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed ... |
42-74 |
1.16e-04 |
|
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed genome to date. An interesting feature of the alignment of all arginyl-tRNA synthetases is a fairly deep split between two families. One family includes archaeal, eukaryotic and organellar, spirochete, E. coli, and Synechocystis sp. The second, sharing a deletion of about 25 residues in the central region relative to the first, includes Bacillus subtilis, Aquifex aeolicus, the Mycoplasmas and Mycobacteria, and the Gram-negative bacterium Helicobacter pylori. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273085 [Multi-domain] Cd Length: 563 Bit Score: 45.80 E-value: 1.16e-04
10 20 30
....*....|....*....|....*....|...
gi 254782503 42 PYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVL 74
Cdd:TIGR00456 121 ANPAGPLHVGHLRNAIIGDSLARILEFLGYDVI 153
|
|
| ArgRS_core |
cd00671 |
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic ... |
42-74 |
2.47e-04 |
|
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. There are at least three subgroups of ArgRS. One type contains both characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The second subtype lacks the KMSKS motif; however, it has a lysine N-terminal to the HIGH motif, which serves as the functional counterpart to the second lysine of the KMSKS motif. A third group, which is found primarily in archaea and a few bacteria, lacks both the KMSKS motif and the HIGH loop lysine.
Pssm-ID: 185675 [Multi-domain] Cd Length: 212 Bit Score: 43.32 E-value: 2.47e-04
10 20 30
....*....|....*....|....*....|...
gi 254782503 42 PYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVL 74
Cdd:cd00671 9 ANPTGPLHVGHLRNAIIGDSLARILEFLGYDVT 41
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
42-112 |
6.86e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 37.84 E-value: 6.86e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254782503 42 PYPSGKLHMGHVRNYTIGDVLSRYMALKGYNVLQPMGWDAFGMPAENAALKNQVAPAAWTYSNIEYMKTQL 112
Cdd:cd00802 6 ITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPANKKGENAKAFVERWIERIKEDV 76
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
48-73 |
6.97e-03 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 39.27 E-value: 6.97e-03
10 20
....*....|....*....|....*.
gi 254782503 48 LHMGHVRNYTIGDVLSRYMALKGYNV 73
Cdd:pfam01406 23 SHIGHARSAVAFDVLRRYLQALGYDV 48
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
44-73 |
9.71e-03 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 39.37 E-value: 9.71e-03
10 20 30
....*....|....*....|....*....|
gi 254782503 44 PSGKLHMGHVRNYTIGDVLSRYMALKGYNV 73
Cdd:PRK01611 122 PTGPLHVGHLRSAVIGDALARILEFAGYDV 151
|
|
| |
