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Conserved domains on  [gi|254547500|gb|ACT66708|]
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toll-like receptor 2 [Sus scrofa]

Protein Classification

toll-like receptor( domain architecture ID 11471630)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-785 1.38e-41

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 148.24  E-value: 1.38e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500   641 CYDAFVSYSGQDsyWVENLMVQELEHFQPPFKLCLHKRDFIPGKWIIDNIIDSIEKSQKTIFVLSENFVKSEWCKYELDF 720
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254547500   721 SHFRLFDENDDTAILILLEPIeKKAIPQRFCKLRKIMnTRTYLEWPADETQRegFWLNLRAAIKS 785
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
298-556 4.55e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 4.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 298 TSALDTIKSLGNVETLTVRRLHIPQFFLFYDLRSIYSLTgAVKRITIENSKVFLVPCSLSQhLKSLEYLDLSENLMSE-- 375
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT-NLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDlp 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 376 EYLKNsacehaWPFLHTLILRQNHLKSLektGEVLVTLKNLTNLDISKNNFDSMPETCQWPEKMKYLNLSSTRIHSLTHC 455
Cdd:COG4886  153 EPLGN------LTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 456 LPQ--TLEVLDISNNNLNSFS--LSLPQLKELYISRNKLKTLPDASFLPMLSVLRISRNTINTFSKEQLDSFQKLKTLEA 531
Cdd:COG4886  224 LANltNLETLDLSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303

                        250       260
                 ....*....|....*....|....*
gi 254547500 532 GGNNFICSCDFLSFTQGQQALAQVL 556
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLL 328
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-316 4.90e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 4.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500  44 LSSIPSGLT--AAVKSLDLSNNRIAYVGSSdLRKCVNLRALGLGANSIHTVEEdSFSSLESLEHLDLSYNHLSNLSSSwF 121
Cdd:COG4886  148 LTDLPEPLGnlTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEP-L 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 122 KSLSTLKFLNLLGNPYKTLgetPLFSHLPNLRILKIGNNdtfaetQAKDFQGLTFLQELEIGASHLQRYAPKSLRSIQNI 201
Cdd:COG4886  225 ANLTNLETLDLSNNQLTDL---PELGNLTNLEELDLSNN------QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELL 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 202 SHLILHMRRPALLPKIFVDLLSSLEYLELRNTDFSTFNFSDVSINEPSTVMKKFTFRKAEITDASFTEIVKLLNYVSGAL 281
Cdd:COG4886  296 LGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 254547500 282 EAEFDDCTLNGRGDFSTSALDTIKSLGNVETLTVR 316
Cdd:COG4886  376 EATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-785 1.38e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 148.24  E-value: 1.38e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500   641 CYDAFVSYSGQDsyWVENLMVQELEHFQPPFKLCLHKRDFIPGKWIIDNIIDSIEKSQKTIFVLSENFVKSEWCKYELDF 720
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254547500   721 SHFRLFDENDDTAILILLEPIeKKAIPQRFCKLRKIMnTRTYLEWPADETQRegFWLNLRAAIKS 785
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
298-556 4.55e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 4.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 298 TSALDTIKSLGNVETLTVRRLHIPQFFLFYDLRSIYSLTgAVKRITIENSKVFLVPCSLSQhLKSLEYLDLSENLMSE-- 375
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT-NLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDlp 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 376 EYLKNsacehaWPFLHTLILRQNHLKSLektGEVLVTLKNLTNLDISKNNFDSMPETCQWPEKMKYLNLSSTRIHSLTHC 455
Cdd:COG4886  153 EPLGN------LTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 456 LPQ--TLEVLDISNNNLNSFS--LSLPQLKELYISRNKLKTLPDASFLPMLSVLRISRNTINTFSKEQLDSFQKLKTLEA 531
Cdd:COG4886  224 LANltNLETLDLSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303

                        250       260
                 ....*....|....*....|....*
gi 254547500 532 GGNNFICSCDFLSFTQGQQALAQVL 556
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLL 328
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-776 1.90e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 88.96  E-value: 1.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500  642 YDAFVSYSGQDSY-WVENLMVQELEHFQppFKLCLHKRDFIPGKWIIDNIIDSIEKSQKTIFVLSENFVKSEWCKYELDF 720
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKELKQKG--IKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254547500  721 S-HFRLfdENDDTAILILLEPIE------KKAIPQRFCKLRKIMNTRTYLEWPADETQREGFW 776
Cdd:pfam01582  79 IlECAL--DLGQKVIPIFYEVDPsdvrkqTGSFGKAFKKHKKVLTEEKVLKWRGALNEVANIW 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-316 4.90e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 4.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500  44 LSSIPSGLT--AAVKSLDLSNNRIAYVGSSdLRKCVNLRALGLGANSIHTVEEdSFSSLESLEHLDLSYNHLSNLSSSwF 121
Cdd:COG4886  148 LTDLPEPLGnlTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEP-L 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 122 KSLSTLKFLNLLGNPYKTLgetPLFSHLPNLRILKIGNNdtfaetQAKDFQGLTFLQELEIGASHLQRYAPKSLRSIQNI 201
Cdd:COG4886  225 ANLTNLETLDLSNNQLTDL---PELGNLTNLEELDLSNN------QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELL 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 202 SHLILHMRRPALLPKIFVDLLSSLEYLELRNTDFSTFNFSDVSINEPSTVMKKFTFRKAEITDASFTEIVKLLNYVSGAL 281
Cdd:COG4886  296 LGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 254547500 282 EAEFDDCTLNGRGDFSTSALDTIKSLGNVETLTVR 316
Cdd:COG4886  376 EATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
334-537 1.59e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 1.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 334 SLTGAVKRITIENSKVFLVPCSLSQhlkSLEYLDLSENLMSEeylknsACEHAWPFLHTLILRQNHLKSLEKTgevlvTL 413
Cdd:PRK15370 217 NLQGNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITE------LPERLPSALQSLDLFHNKISCLPEN-----LP 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 414 KNLTNLDISKNNFDSMPEtcQWPEKMKYLNLSSTRIHSLTHCLPQTLEVLDISNNNLNSFSLSLP-QLKELYISRNKLKT 492
Cdd:PRK15370 283 EELRYLSVYDNSIRTLPA--HLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPpELQVLDVSKNQITV 360

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 254547500 493 LPDaSFLPMLSVLRISRNTINTFSkEQLDSfqKLKTLEAGGNNFI 537
Cdd:PRK15370 361 LPE-TLPPTITTLDVSRNALTNLP-ENLPA--ALQIMQASRNNLV 401
LRR_8 pfam13855
Leucine rich repeat;
78-136 1.38e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 1.38e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 254547500   78 NLRALGLGANSIHTVEEDSFSSLESLEHLDLSYNHLSNLSSSWFKSLSTLKFLNLLGNP 136
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN03150 PLN03150
hypothetical protein; Provisional
 55-135 7.55e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.51  E-value: 7.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500  55 VKSLDLSNNRIAYVGSSDLRKCVNLRALGLGANSIHTVEEDSFSSLESLEHLDLSYNHLSNLSSSWFKSLSTLKFLNLLG 134
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNG 499


                 .
gi 254547500 135 N 135
Cdd:PLN03150 500 N 500
LRR_8 pfam13855
Leucine rich repeat;
478-536 4.53e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.53e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254547500  478 PQLKELYISRNKLKTLPDASF--LPMLSVLRISRNTINTFSKEQLDSFQKLKTLEAGGNNF 536
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 390-534 6.97e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 6.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 390 LHTLILRQNHLKSLEKtgevLVTLKNLTNLDISKN------NFDSMPetcqwpeKMKYLNLSSTRIHSLT--HCLPQtLE 461
Cdd:cd21340   26 LKVLYLYDNKITKIEN----LEFLTNLTHLYLQNNqiekieNLENLV-------NLKKLYLGGNRISVVEglENLTN-LE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 462 VLDISNNNL--------NSFSLS--LPQLKELYISRNKLKTLPDASFLPMLSVLRISRNTINTFS--KEQLDSFQKLKTL 529
Cdd:cd21340   94 ELHIENQRLppgekltfDPRSLAalSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLREL 173


                 ....*
gi 254547500 530 EAGGN 534
Cdd:cd21340  174 DLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 58-136 6.16e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 6.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500  58 LDLSNNRIAYVgsSDLRKCVNLRALGLGA-------------NSIHTVEE---------------DSFSSLESLEHLDLS 109
Cdd:cd21340   73 LYLGGNRISVV--EGLENLTNLEELHIENqrlppgekltfdpRSLAALSNslrvlnisgnnidslEPLAPLRNLEQLDAS 150

                         90       100
                 ....*....|....*....|....*....
gi 254547500 110 YNHLSNLS--SSWFKSLSTLKFLNLLGNP 136
Cdd:cd21340  151 NNQISDLEelLDLLSSWPSLRELDLTGNP 179
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-785 1.38e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 148.24  E-value: 1.38e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500   641 CYDAFVSYSGQDsyWVENLMVQELEHFQPPFKLCLHKRDFIPGKWIIDNIIDSIEKSQKTIFVLSENFVKSEWCKYELDF 720
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254547500   721 SHFRLFDENDDTAILILLEPIeKKAIPQRFCKLRKIMnTRTYLEWPADETQRegFWLNLRAAIKS 785
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
298-556 4.55e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 4.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 298 TSALDTIKSLGNVETLTVRRLHIPQFFLFYDLRSIYSLTgAVKRITIENSKVFLVPCSLSQhLKSLEYLDLSENLMSE-- 375
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT-NLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDlp 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 376 EYLKNsacehaWPFLHTLILRQNHLKSLektGEVLVTLKNLTNLDISKNNFDSMPETCQWPEKMKYLNLSSTRIHSLTHC 455
Cdd:COG4886  153 EPLGN------LTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 456 LPQ--TLEVLDISNNNLNSFS--LSLPQLKELYISRNKLKTLPDASFLPMLSVLRISRNTINTFSKEQLDSFQKLKTLEA 531
Cdd:COG4886  224 LANltNLETLDLSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303

                        250       260
                 ....*....|....*....|....*
gi 254547500 532 GGNNFICSCDFLSFTQGQQALAQVL 556
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLL 328
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-776 1.90e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 88.96  E-value: 1.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500  642 YDAFVSYSGQDSY-WVENLMVQELEHFQppFKLCLHKRDFIPGKWIIDNIIDSIEKSQKTIFVLSENFVKSEWCKYELDF 720
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKELKQKG--IKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254547500  721 S-HFRLfdENDDTAILILLEPIE------KKAIPQRFCKLRKIMNTRTYLEWPADETQREGFW 776
Cdd:pfam01582  79 IlECAL--DLGQKVIPIFYEVDPsdvrkqTGSFGKAFKKHKKVLTEEKVLKWRGALNEVANIW 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-316 4.90e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 4.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500  44 LSSIPSGLT--AAVKSLDLSNNRIAYVGSSdLRKCVNLRALGLGANSIHTVEEdSFSSLESLEHLDLSYNHLSNLSSSwF 121
Cdd:COG4886  148 LTDLPEPLGnlTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEP-L 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 122 KSLSTLKFLNLLGNPYKTLgetPLFSHLPNLRILKIGNNdtfaetQAKDFQGLTFLQELEIGASHLQRYAPKSLRSIQNI 201
Cdd:COG4886  225 ANLTNLETLDLSNNQLTDL---PELGNLTNLEELDLSNN------QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELL 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 202 SHLILHMRRPALLPKIFVDLLSSLEYLELRNTDFSTFNFSDVSINEPSTVMKKFTFRKAEITDASFTEIVKLLNYVSGAL 281
Cdd:COG4886  296 LGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 254547500 282 EAEFDDCTLNGRGDFSTSALDTIKSLGNVETLTVR 316
Cdd:COG4886  376 EATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
334-537 1.59e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 1.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 334 SLTGAVKRITIENSKVFLVPCSLSQhlkSLEYLDLSENLMSEeylknsACEHAWPFLHTLILRQNHLKSLEKTgevlvTL 413
Cdd:PRK15370 217 NLQGNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITE------LPERLPSALQSLDLFHNKISCLPEN-----LP 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 414 KNLTNLDISKNNFDSMPEtcQWPEKMKYLNLSSTRIHSLTHCLPQTLEVLDISNNNLNSFSLSLP-QLKELYISRNKLKT 492
Cdd:PRK15370 283 EELRYLSVYDNSIRTLPA--HLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPpELQVLDVSKNQITV 360

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 254547500 493 LPDaSFLPMLSVLRISRNTINTFSkEQLDSfqKLKTLEAGGNNFI 537
Cdd:PRK15370 361 LPE-TLPPTITTLDVSRNALTNLP-ENLPA--ALQIMQASRNNLV 401
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 645-719 3.75e-14

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 69.27  E-value: 3.75e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254547500  645 FVSYSGQDSYWVENLmVQELEhfQPPFKLCLHKRDFIPGKWIIDNIIDSIEKSQKTIFVLSENFVKSEWCKYELD 719
Cdd:pfam13676   2 FISYAGEDRAWAEWL-ADALE--AAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWE 73
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-207 9.74e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 9.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500  55 VKSLDLSNNRiayvgssDLRKCVNLRALGLGANSIhTVEEDSFSSLESLEHLDLSYNHLSNLSSSwFKSLSTLKFLNLLG 134
Cdd:COG4886   98 LTELDLSGNE-------ELSNLTNLESLDLSGNQL-TDLPEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSN 168

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254547500 135 NPYKTLGETplFSHLPNLRILKIGNNDTfaETQAKDFQGLTFLQELEIGASHLqRYAPKSLRSIQNISHLILH 207
Cdd:COG4886  169 NQLTDLPEE--LGNLTNLKELDLSNNQI--TDLPEPLGNLTNLEELDLSGNQL-TDLPEPLANLTNLETLDLS 236
LRR_8 pfam13855
Leucine rich repeat;
78-136 1.38e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 1.38e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 254547500   78 NLRALGLGANSIHTVEEDSFSSLESLEHLDLSYNHLSNLSSSWFKSLSTLKFLNLLGNP 136
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
341-581 2.34e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 64.33  E-value: 2.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 341 RITIENSKVFLVPCSLSQHLKSL-----EYLDLSENLMSEeylknsacehawpfLHTLILRQNHLKSLEKT-----GEVL 410
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTLildnnELKSLPENLQGN--------------IKTLYANSNQLTSIPATlpdtiQEME 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 411 VTLKNLT-----------NLDISKNNFDSMPETCqwPEKMKYLNLSSTRIHSLTHCLPQTLEVLDISNNNLNSFSLSLP- 478
Cdd:PRK15370 248 LSINRITelperlpsalqSLDLFHNKISCLPENL--PEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPp 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 479 QLKELYISRNKLKTLPdASFLPMLSVLRISRNTInTFSKEQLDSfqKLKTLEAGGNNFICSCDFL-SFTQGQQALAQVLS 557
Cdd:PRK15370 326 GLKTLEAGENALTSLP-ASLPPELQVLDVSKNQI-TVLPETLPP--TITTLDVSRNALTNLPENLpAALQIMQASRNNLV 401

                        250       260
                 ....*....|....*....|....
gi 254547500 558 DWPEnylcdSPSHVRGQRVQDTRL 581
Cdd:PRK15370 402 RLPE-----SLPHFRGEGPQPTRI 420
LRR_8 pfam13855
Leucine rich repeat;
55-113 1.71e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.71e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 254547500   55 VKSLDLSNNRIAYVGSSDLRKCVNLRALGLGANSIHTVEEDSFSSLESLEHLDLSYNHL 113
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 55-135 7.55e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.51  E-value: 7.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500  55 VKSLDLSNNRIAYVGSSDLRKCVNLRALGLGANSIHTVEEDSFSSLESLEHLDLSYNHLSNLSSSWFKSLSTLKFLNLLG 134
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNG 499


                 .
gi 254547500 135 N 135
Cdd:PLN03150 500 N 500
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 51-536 3.82e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 3.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500  51 LTAAVKSLDLSNNRiaYVGSSDLRKCVNLRALGLGANSIHTVEEDSFSSLESLEHLDLSYNHLSNLSSSWFKSLSTLKFL 130
Cdd:PLN00113 116 TSSSLRYLNLSNNN--FTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFL 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 131 NLLGNpyKTLGETPL-FSHLPNLRILKIGNNDTFAETqAKDFQGLTFLQELEIGASHLQRYAPKSLRSIQNISHLILHMR 209
Cdd:PLN00113 194 TLASN--QLVGQIPReLGQMKSLKWIYLGYNNLSGEI-PYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 210 RPA--LLPKIFvdllssleylelRNTDFSTFNFSDVSINE--PSTVMKKFTFrkaeitdasftEIVKLlnyvsgaleaef 285
Cdd:PLN00113 271 KLSgpIPPSIF------------SLQKLISLDLSDNSLSGeiPELVIQLQNL-----------EILHL------------ 315

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 286 ddctlngrgdFSTSALDTIKslgnVETLTVRRLHIPQFFlfydlrsIYSLTGAVkritienskvflvPCSLSQHlKSLEY 365
Cdd:PLN00113 316 ----------FSNNFTGKIP----VALTSLPRLQVLQLW-------SNKFSGEI-------------PKNLGKH-NNLTV 360

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 366 LDLSENLMSEEyLKNSACEHAwpFLHTLILRQNhlkSLEktGEV---LVTLKNLTNLDISKNNFD-SMPETCQWPEKMKY 441
Cdd:PLN00113 361 LDLSTNNLTGE-IPEGLCSSG--NLFKLILFSN---SLE--GEIpksLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYF 432

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 442 LNLSST----RIHSLTHCLPQtLEVLDISNNNlnsFSLSLP------QLKELYISRNKLKTLPDASF--LPMLSVLRISR 509
Cdd:PLN00113 433 LDISNNnlqgRINSRKWDMPS-LQMLSLARNK---FFGGLPdsfgskRLENLDLSRNQFSGAVPRKLgsLSELMQLKLSE 508

                        490       500
                 ....*....|....*....|....*..
gi 254547500 510 NTINTFSKEQLDSFQKLKTLEAGGNNF 536
Cdd:PLN00113 509 NKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR_8 pfam13855
Leucine rich repeat;
478-536 4.53e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.53e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254547500  478 PQLKELYISRNKLKTLPDASF--LPMLSVLRISRNTINTFSKEQLDSFQKLKTLEAGGNNF 536
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
458-510 6.78e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 6.78e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 254547500  458 QTLEVLDISNNNLNSFS----LSLPQLKELYISRNKLKTLPDASF--LPMLSVLRISRN 510
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgafKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 390-534 6.97e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 6.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 390 LHTLILRQNHLKSLEKtgevLVTLKNLTNLDISKN------NFDSMPetcqwpeKMKYLNLSSTRIHSLT--HCLPQtLE 461
Cdd:cd21340   26 LKVLYLYDNKITKIEN----LEFLTNLTHLYLQNNqiekieNLENLV-------NLKKLYLGGNRISVVEglENLTN-LE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 462 VLDISNNNL--------NSFSLS--LPQLKELYISRNKLKTLPDASFLPMLSVLRISRNTINTFS--KEQLDSFQKLKTL 529
Cdd:cd21340   94 ELHIENQRLppgekltfDPRSLAalSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLREL 173


                 ....*
gi 254547500 530 EAGGN 534
Cdd:cd21340  174 DLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-207 9.11e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 9.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500  43 SLSSIPSGLTAAVKSLDLSNNRIAYVGSSDLRKCVNLRALGLGANSIHTVEEDSFSSLESLEHLDLSYNhlsnlssSWFK 122
Cdd:COG4886   38 LLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 123 SLSTLKFLNLLGNPYKTLGETplFSHLPNLRILKIGNNDTfaETQAKDFQGLTFLQELEIGASHLQRyAPKSLRSIQNIS 202
Cdd:COG4886  111 NLTNLESLDLSGNQLTDLPEE--LANLTNLKELDLSNNQL--TDLPEPLGNLTNLKSLDLSNNQLTD-LPEELGNLTNLK 185


                 ....*
gi 254547500 203 HLILH 207
Cdd:COG4886  186 ELDLS 190
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
335-481 1.35e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 335 LTGAVKRITIENSKVFLVPCSLSQHLKSLEYLD-----LSENLMS---EEYLKNSAC----EHAWPFLHTLILRQNHLKS 402
Cdd:PRK15370 260 LPSALQSLDLFHNKISCLPENLPEELRYLSVYDnsirtLPAHLPSgitHLNVQSNSLtalpETLPPGLKTLEAGENALTS 339

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254547500 403 LEKTgevlvTLKNLTNLDISKNNFDSMPETCqwPEKMKYLNLSSTRIHSLTHCLPQTLEVLDISNNNLNSFSLSLPQLK 481
Cdd:PRK15370 340 LPAS-----LPPELQVLDVSKNQITVLPETL--PPTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPESLPHFR 411
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
388-534 3.28e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.38  E-value: 3.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 388 PFLHTLILRQNHLKSLEKTGEVLVTL--------------KNLTNLDISKNNFDSMPETcqwPEKMKYLNLSSTRIHSLT 453
Cdd:PRK15387 302 PGLQELSVSDNQLASLPALPSELCKLwaynnqltslptlpSGLQELSVSDNQLASLPTL---PSELYKLWAYNNRLTSLP 378

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 454 hCLPQTLEVLDISNNNLNSFSLSLPQLKELYISRNKLKTLPdasFLPM-LSVLRISRNTINTFSkEQLDSFQKLKTLEAG 532
Cdd:PRK15387 379 -ALPSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLP---MLPSgLLSLSVYRNQLTRLP-ESLIHLSSETTVNLE 453


                 ..
gi 254547500 533 GN 534
Cdd:PRK15387 454 GN 455
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-541 4.82e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 4.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500  47 IPSGLT--AAVKSLDLSNNRIAYVGSSDLRKCVNLRALGLGANSIHTVEEDSFSSLESLEHLDLSYNHLSNLSSSWFKSL 124
Cdd:PLN00113 180 IPNSLTnlTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNL 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 125 STLKFLNLLGNpyKTLGETP--LFShLPNLRILKIGNNDTFAETQAKDFQgltfLQELEI---GASHLQRYAPKSLRSIQ 199
Cdd:PLN00113 260 KNLQYLFLYQN--KLSGPIPpsIFS-LQKLISLDLSDNSLSGEIPELVIQ----LQNLEIlhlFSNNFTGKIPVALTSLP 332

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 200 NISHLILHMRR-----PALLPKifvdllssleylelRNtdfsTFNFSDVSINEPStvmkkftfrkAEITDA--SFTEIVK 272
Cdd:PLN00113 333 RLQVLQLWSNKfsgeiPKNLGK--------------HN----NLTVLDLSTNNLT----------GEIPEGlcSSGNLFK 384

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 273 LLNYvSGALEAEFDdctlngrgdfstsaldtiKSLGNVETLtvRRLHIPQFFLFYDLRSIYSLTGAVKRITIENSKVFLV 352
Cdd:PLN00113 385 LILF-SNSLEGEIP------------------KSLGACRSL--RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGR 443

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 353 PCSLSQHLKSLEYLDLSENLMSEEYLKNSACehawpflhtlilrqnhlkslektgevlvtlKNLTNLDISKNNFDSM-PE 431
Cdd:PLN00113 444 INSRKWDMPSLQMLSLARNKFFGGLPDSFGS------------------------------KRLENLDLSRNQFSGAvPR 493

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 432 TC-QWPEKMKyLNLSSTRI-----HSLTHClpQTLEVLDISNNNLN-----SFSlSLPQLKELYISRNKL--KTLPDASF 498
Cdd:PLN00113 494 KLgSLSELMQ-LKLSENKLsgeipDELSSC--KKLVSLDLSHNQLSgqipaSFS-EMPVLSQLDLSQNQLsgEIPKNLGN 569

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 254547500 499 LPMLSVLRISRNTINTfSKEQLDSFQKLKTLEAGGNNFICSCD 541
Cdd:PLN00113 570 VESLVQVNISHNHLHG-SLPSTGAFLAINASAVAGNIDLCGGD 611
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 58-136 6.16e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 6.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500  58 LDLSNNRIAYVgsSDLRKCVNLRALGLGA-------------NSIHTVEE---------------DSFSSLESLEHLDLS 109
Cdd:cd21340   73 LYLGGNRISVV--EGLENLTNLEELHIENqrlppgekltfdpRSLAALSNslrvlnisgnnidslEPLAPLRNLEQLDAS 150

                         90       100
                 ....*....|....*....|....*....
gi 254547500 110 YNHLSNLS--SSWFKSLSTLKFLNLLGNP 136
Cdd:cd21340  151 NNQISDLEelLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
438-490 8.70e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 8.70e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254547500  438 KMKYLNLSSTRIHSLT----HCLPQtLEVLDISNNNLNSFSL----SLPQLKELYISRNKL 490
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgafKGLSN-LKVLDLSNNLLTTLSPgafsGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 304-420 8.72e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 8.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 304 IKSLGNVETLT-VRRLHI------PQFFLFYDLRSIYSLTGAVKRITIENSKVflvpCSLSQ--HLKSLEYLDLSENLMS 374
Cdd:cd21340   80 ISVVEGLENLTnLEELHIenqrlpPGEKLTFDPRSLAALSNSLRVLNISGNNI----DSLEPlaPLRNLEQLDASNNQIS 155

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 254547500 375 E-EYLKNSACehAWPFLHTLILRQNHLKSLEKTGEVLVTL-KNLTNLD 420
Cdd:cd21340  156 DlEELLDLLS--SWPSLRELDLTGNPVCKKPKYRDKIILAsKSLEVLD 201
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 408-534 1.43e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 408 EVLVTLKNLTNlDISK--NNFDSMPETCQW-------PEKMKYLNLS----STRIHSLTHCLPqTLEVLDISNNNL---- 470
Cdd:PLN00113  32 ELLLSFKSSIN-DPLKylSNWNSSADVCLWqgitcnnSSRVVSIDLSgkniSGKISSAIFRLP-YIQTINLSNNQLsgpi 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254547500 471 --NSFSLSlPQLKELYISRNKLKTLPDASFLPMLSVLRISRNTINTFSKEQLDSFQKLKTLEAGGN 534
Cdd:PLN00113 110 pdDIFTTS-SSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN 174
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
442-494 1.43e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 1.43e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 254547500 442 LNLSSTRIHSLTHCLPQTLEVLDISNNNLNSFSLSLPQLKELYISRNKLKTLP 494
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLP 258
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 441-529 2.67e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254547500 441 YLN-LSSTRIHSLTHClpQTLEVLDISNNNLNSFS--LSLPQLKELYISRNKLKTLPDASFLPMLSVLRISRNTINTFsk 517
Cdd:cd21340    8 YLNdKNITKIDNLSLC--KNLKVLYLYDNKITKIEnlEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVV-- 83

                         90
                 ....*....|..
gi 254547500 518 EQLDSFQKLKTL 529
Cdd:cd21340   84 EGLENLTNLEEL 95
LRR_8 pfam13855
Leucine rich repeat;
390-449 3.42e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 3.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254547500  390 LHTLILRQNHLKSLEKtgEVLVTLKNLTNLDISKNNFDSM-PETCQWPEKMKYLNLSSTRI 449
Cdd:pfam13855   3 LRSLDLSNNRLTSLDD--GAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 458-495 7.74e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 7.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 254547500  458 QTLEVLDISNNNLNSFSL--SLPQLKELYISRN-KLKTLPD 495
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPlaKLPNLETLDLSGNnKITDLSD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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