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Conserved domains on  [gi|251757450|sp|P14543|]
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RecName: Full=Nidogen-1; Short=NID-1; AltName: Full=Entactin; Flags: Precursor

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 11272459)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 429-660 2.52e-108

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


:

Pssm-ID: 238158  Cd Length: 224  Bit Score: 339.67  E-value: 2.52e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  429 GSPQRVNGKVKGRIFVGSSqvPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNG 508
Cdd:cd00255     1 GIPQRVNGKVSGNINVGQS--PVEFGDADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  509 FSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVI-TSSSTR 587
Cdd:cd00255    79 FSLTGGEFTRQAEVTFYTGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPGVlTSSSTR 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 251757450  588 EYTVTEPerdgaSPSRIYTYQWRQTITFQECVHDDsrPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPV 660
Cdd:cd00255   159 EYTVDEG-----GESQTLSYQWNQTITYEECPHDD--EAAPDLQQLLVARIFALYNPEEEILRFAITNSIGPG 224
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
106-269 3.11e-45

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


:

Pssm-ID: 214712  Cd Length: 152  Bit Score: 160.29  E-value: 3.11e-45
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450    106 PFLADLDTtDGLGKVYYREDLSPSITQRAAECVHRGFPE-ISFQPSSAVVVTWESVAPYQGPSRDPdqkgkRNTFQAVLA 184
Cdd:smart00539    1 PFWADADT-EGTGKVYYRETTDHAILDRATESVREGFTDmGGFRAKSVVIVTWENVAAYGSQSSDG-----TNTFQAVLA 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450    185 SSDSSSYAIFLYPEDGLQFHTTFSKKenNQVPAVVAFSQGSVGFlwksngAYNIFANDRESVENLAKSSNSGQQGVWVFE 264
Cdd:smart00539   75 TDGSRTYAIFLYPSLGWTSDTTAGGD--DGVRARAGFNGGDGTF------SYTLPASGEENIKNLAEGSNVGIPGRWMFR 146


                    ....*
gi 251757450    265 IGSPA 269
Cdd:smart00539  147 VDGAE 151
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 849-919 1.79e-28

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 108.93  E-value: 1.79e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 251757450   849 CQHEREHILGAAGATDPqrpiPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMtPPC 919
Cdd:pfam00086    1 CERERARALEQAASGRP----ASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGD-PDC 66
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1014-1055 9.55e-14

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 66.47  E-value: 9.55e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 251757450   1014 TIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQR 1055
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 811-839 5.24e-12

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 61.08  E-value: 5.24e-12
                           10        20
                   ....*....|....*....|....*....
gi 251757450   811 CHPDAFCYNTPGSFTCQCKPGYQGDGFRC 839
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1056-1100 2.45e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.54  E-value: 2.45e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 251757450   1056 RVLFETDLVNPRGIVTDSVRGNLYWTDWNRDnpKIETSYMDGTNR 1100
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD--VIEVANLDGTNR 43
Vgb super family cl26743
Streptogramin lyase [Defense mechanisms];
934-1177 1.17e-09

Streptogramin lyase [Defense mechanisms];


The actual alignment was detected with superfamily member COG4257:

Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 60.80  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  934 PTAVIPLPPGThLLFAQT--GKIERLPLEGNTMRKTEAKAFLHVpakviIGLAFDcVDKMVYWTDITEPSIGRASLHGGE 1011
Cdd:COG4257    19 PRDVAVDPDGA-VWFTDQggGRIGRLDPATGEFTEYPLGGGSGP-----HGIAVD-PDGNLWFTDNGNNRIGRIDPKTGE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1012 PTTI-IRQDLGSPEGIAVDHLGrNIFWTDSNLDRIevAKLDGTQRRVL---FETDLVNPRGIVTDSvRGNLYWTDWNRDN 1087
Cdd:COG4257    92 ITTFaLPGGGSNPHGIAFDPDG-NLWFTDQGGNRI--GRLDPATGEVTefpLPTGGAGPYGIAVDP-DGNLWVTDFGANA 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1088 P-KIETSymDGTNRRILVQDDLGLPNGLTFDAfSSQLCWVDAGTNRAECLNPS--------QPSRRKALEGLqypfAVTS 1158
Cdd:COG4257   168 IgRIDPD--TGTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGSGRIGRFDPKtgtvteypLPGGGARPYGV----AVDG 240

                         250
                  ....*....|....*....
gi 251757450 1159 YGkNLYFTDWKMNSVVALD 1177
Cdd:COG4257   241 DG-RVWFAESGANRIVRFD 258
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1212-1236 2.73e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 53.40  E-value: 2.73e-09
                           10        20
                   ....*....|....*....|....*
gi 251757450  1212 CSVNNGGCTHLCLATPGSRTCRCPD 1236
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 762-800 2.89e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 50.68  E-value: 2.89e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 251757450   762 CETGLHNCDipQRAQCIYTGGSsYTCSCLPGFSGDGQAC 800
Cdd:pfam12947    1 CSDNNGGCH--PNATCTNTGGS-FTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 390-425 4.27e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 50.29  E-value: 4.27e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 251757450   390 CANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQC 425
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
710-751 2.72e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 2.72e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 251757450    710 DIDECSEqPSVCGSHTICNNHPGTFRCECVEGYQfsDEGTCV 751
Cdd:smart00179    1 DIDECAS-GNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 672-708 3.34e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 3.34e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 251757450   672 CYIGTHGCDTNAACRPGPrTQFTCECSIGFRGDGRTC 708
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTG-GSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 429-660 2.52e-108

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 339.67  E-value: 2.52e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  429 GSPQRVNGKVKGRIFVGSSqvPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNG 508
Cdd:cd00255     1 GIPQRVNGKVSGNINVGQS--PVEFGDADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  509 FSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVI-TSSSTR 587
Cdd:cd00255    79 FSLTGGEFTRQAEVTFYTGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPGVlTSSSTR 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 251757450  588 EYTVTEPerdgaSPSRIYTYQWRQTITFQECVHDDsrPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPV 660
Cdd:cd00255   159 EYTVDEG-----GESQTLSYQWNQTITYEECPHDD--EAAPDLQQLLVARIFALYNPEEEILRFAITNSIGPG 224
G2F smart00682
G2 nidogen domain and fibulin;
427-666 1.90e-100

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 318.23  E-value: 1.90e-100
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450    427 AEGSPQRVNGKVKGRIFVGssQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFK 506
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVG--EFPVAFENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAV 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450    507 NGFSITGGEFTRQAEVTFvGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTS-VITSSS 585
Cdd:smart00682   79 NGFQLTGGVFTRETEVTF-AGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTGPgVLTTSS 157

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450    586 TREYTVteperdgasPSRIYTYQWRQTITFQECVHDDsrPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSP 665
Cdd:smart00682  158 TREYTV---------DNQTHSYTVDQTITFEECQHRD--AFPPTTQQLHVSSVFVDYNDEERVLRFAAHNSVGPGDESNQ 226


                    .
gi 251757450    666 D 666
Cdd:smart00682  227 C 227
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 429-622 5.16e-79

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 257.52  E-value: 5.16e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450   429 GSPQRVNGKVKGRIfvgssqVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNG 508
Cdd:pfam07474    1 GVPQRVNGKVSGTI------NGVEFGDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFALEQGGAKNG 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450   509 FSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVI-TSSSTR 587
Cdd:pfam07474   75 FSLTGGVFNRTAEVTFPPTGERLTITQEFRGLDEDGHLVVDTVISGTVPQVPAGSTVIIEDYTELYQYTGPGElTSSSTR 154

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 251757450   588 EYTVTEPERDgaspsRIYTYQWRQTITFQECVHDD 622
Cdd:pfam07474  155 TYTVDGEGNT-----RTISYTVNQTITYQECRHAE 184
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
106-269 3.11e-45

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 160.29  E-value: 3.11e-45
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450    106 PFLADLDTtDGLGKVYYREDLSPSITQRAAECVHRGFPE-ISFQPSSAVVVTWESVAPYQGPSRDPdqkgkRNTFQAVLA 184
Cdd:smart00539    1 PFWADADT-EGTGKVYYRETTDHAILDRATESVREGFTDmGGFRAKSVVIVTWENVAAYGSQSSDG-----TNTFQAVLA 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450    185 SSDSSSYAIFLYPEDGLQFHTTFSKKenNQVPAVVAFSQGSVGFlwksngAYNIFANDRESVENLAKSSNSGQQGVWVFE 264
Cdd:smart00539   75 TDGSRTYAIFLYPSLGWTSDTTAGGD--DGVRARAGFNGGDGTF------SYTLPASGEENIKNLAEGSNVGIPGRWMFR 146


                    ....*
gi 251757450    265 IGSPA 269
Cdd:smart00539  147 VDGAE 151
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 849-919 1.79e-28

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 108.93  E-value: 1.79e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 251757450   849 CQHEREHILGAAGATDPqrpiPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMtPPC 919
Cdd:pfam00086    1 CERERARALEQAASGRP----ASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGD-PDC 66
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 176-267 5.34e-28

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 108.53  E-value: 5.34e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450   176 RNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENN---QVPAVVAFSQGsvgfLWKSNgAYNIFANDRESVENLAKS 252
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDGGIQWTTGKASGGTNglgGTPAQAGFSAG----DGDGR-YYELPGSGTDSIRNLTET 75

                           90
                   ....*....|....*
gi 251757450   253 SNSGQQGVWVFEIGS 267
Cdd:pfam06119   76 SNVGVPGRWVFRIDS 90
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 849-919 3.94e-25

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 99.46  E-value: 3.94e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 251757450  849 CQHEREHILGAAGatdpqRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGmTPPC 919
Cdd:cd00191     2 CERERASALESLA-----GPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGG-PPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 875-921 8.31e-17

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 75.11  E-value: 8.31e-17
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 251757450    875 VPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTrPGMTPPCLS 921
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRT-EGGDPDCPS 46
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1014-1055 9.55e-14

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 66.47  E-value: 9.55e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 251757450   1014 TIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQR 1055
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 811-839 5.24e-12

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 61.08  E-value: 5.24e-12
                           10        20
                   ....*....|....*....|....*....
gi 251757450   811 CHPDAFCYNTPGSFTCQCKPGYQGDGFRC 839
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1056-1100 2.45e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.54  E-value: 2.45e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 251757450   1056 RVLFETDLVNPRGIVTDSVRGNLYWTDWNRDnpKIETSYMDGTNR 1100
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD--VIEVANLDGTNR 43
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
934-1177 1.17e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 60.80  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  934 PTAVIPLPPGThLLFAQT--GKIERLPLEGNTMRKTEAKAFLHVpakviIGLAFDcVDKMVYWTDITEPSIGRASLHGGE 1011
Cdd:COG4257    19 PRDVAVDPDGA-VWFTDQggGRIGRLDPATGEFTEYPLGGGSGP-----HGIAVD-PDGNLWFTDNGNNRIGRIDPKTGE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1012 PTTI-IRQDLGSPEGIAVDHLGrNIFWTDSNLDRIevAKLDGTQRRVL---FETDLVNPRGIVTDSvRGNLYWTDWNRDN 1087
Cdd:COG4257    92 ITTFaLPGGGSNPHGIAFDPDG-NLWFTDQGGNRI--GRLDPATGEVTefpLPTGGAGPYGIAVDP-DGNLWVTDFGANA 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1088 P-KIETSymDGTNRRILVQDDLGLPNGLTFDAfSSQLCWVDAGTNRAECLNPS--------QPSRRKALEGLqypfAVTS 1158
Cdd:COG4257   168 IgRIDPD--TGTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGSGRIGRFDPKtgtvteypLPGGGARPYGV----AVDG 240

                         250
                  ....*....|....*....
gi 251757450 1159 YGkNLYFTDWKMNSVVALD 1177
Cdd:COG4257   241 DG-RVWFAESGANRIVRFD 258
EGF_CA smart00179
Calcium-binding EGF-like domain;
802-840 1.25e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 54.56  E-value: 1.25e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 251757450    802 DVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQgDGFRCV 840
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 992-1030 2.15e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.09  E-value: 2.15e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 251757450   992 VYWTD-ITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDH 1030
Cdd:pfam00058    3 LYWTDsSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1212-1236 2.73e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 53.40  E-value: 2.73e-09
                           10        20
                   ....*....|....*....|....*
gi 251757450  1212 CSVNNGGCTHLCLATPGSRTCRCPD 1236
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 802-840 7.23e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 7.23e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 251757450  802 DVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGDgfRCV 840
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGR--NCE 38
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1019-1176 2.68e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 56.56  E-value: 2.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1019 DLGSPEGIAVDHLGrNIFWTDSNLDRIEVAKLDGTQRRVL-----FETDLVNPRGIVTDSVrGNLYWTDWNRD-----NP 1088
Cdd:cd05819   100 EFNGPRGIAVDSSG-NIYVADTGNHRIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHriqvfDP 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1089 kiETSYMDGTNRRILVQDDLGLPNGLTFDafSSQLCWV-DAGTNRAECLNPSQP------SRRKALEGLQYPF--AVTSY 1159
Cdd:cd05819   178 --DGNFLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYVaDSGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSglAVDSD 253

                         170
                  ....*....|....*..
gi 251757450 1160 GkNLYFTDWKMNSVVAL 1176
Cdd:cd05819   254 G-NLYVADTGNNRIQVF 269
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1033-1072 2.75e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.01  E-value: 2.75e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 251757450  1033 RNIFWTDSNLD-RIEVAKLDGTQRRVLFETDLVNPRGIVTD 1072
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 762-800 2.89e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 50.68  E-value: 2.89e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 251757450   762 CETGLHNCDipQRAQCIYTGGSsYTCSCLPGFSGDGQAC 800
Cdd:pfam12947    1 CSDNNGGCH--PNATCTNTGGS-FTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 390-425 4.27e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 50.29  E-value: 4.27e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 251757450   390 CANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQC 425
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1076-1117 9.53e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 9.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 251757450  1076 GNLYWTDWNRDnPKIETSYMDGTNRRILVQDDLGLPNGLTFD 1117
Cdd:pfam00058    1 GRLYWTDSSLR-ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
EGF_CA smart00179
Calcium-binding EGF-like domain;
710-751 2.72e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 2.72e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 251757450    710 DIDECSEqPSVCGSHTICNNHPGTFRCECVEGYQfsDEGTCV 751
Cdd:smart00179    1 DIDECAS-GNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 672-708 3.34e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 3.34e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 251757450   672 CYIGTHGCDTNAACRPGPrTQFTCECSIGFRGDGRTC 708
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTG-GSFTCTCNDGYTGDGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 710-743 2.68e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.68e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 251757450  710 DIDECSEqPSVCGSHTICNNHPGTFRCECVEGYQ 743
Cdd:cd00054     1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 982-1011 2.90e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 2.90e-06
                            10        20        30
                    ....*....|....*....|....*....|
gi 251757450    982 GLAFDCVDKMVYWTDITEPSIGRASLHGGE 1011
Cdd:smart00135   13 GLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
EGF_CA pfam07645
Calcium-binding EGF domain;
710-741 1.78e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 1.78e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 251757450   710 DIDECSEQPSVCGSHTICNNHPGTFRCECVEG 741
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
759-801 5.94e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 5.94e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 251757450    759 INYCETGlHNCDipQRAQCIYTGGSsYTCSCLPGFSgDGQACQ 801
Cdd:smart00179    2 IDECASG-NPCQ--NGGTCVNTVGS-YRCECPPGYT-DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 390-426 6.91e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 251757450  390 CANNrHQCSVHAECRDYATGFCCSCVAGYTgnGRQCV 426
Cdd:cd00054     5 CASG-NPCQNGGTCVNTVGSYRCSCPPGYT--GRNCE 38
 
Name Accession Description Interval E-value
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 429-660 2.52e-108

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 339.67  E-value: 2.52e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  429 GSPQRVNGKVKGRIFVGSSqvPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNG 508
Cdd:cd00255     1 GIPQRVNGKVSGNINVGQS--PVEFGDADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  509 FSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVI-TSSSTR 587
Cdd:cd00255    79 FSLTGGEFTRQAEVTFYTGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPGVlTSSSTR 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 251757450  588 EYTVTEPerdgaSPSRIYTYQWRQTITFQECVHDDsrPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPV 660
Cdd:cd00255   159 EYTVDEG-----GESQTLSYQWNQTITYEECPHDD--EAAPDLQQLLVARIFALYNPEEEILRFAITNSIGPG 224
G2F smart00682
G2 nidogen domain and fibulin;
427-666 1.90e-100

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 318.23  E-value: 1.90e-100
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450    427 AEGSPQRVNGKVKGRIFVGssQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFK 506
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVG--EFPVAFENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAV 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450    507 NGFSITGGEFTRQAEVTFvGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTS-VITSSS 585
Cdd:smart00682   79 NGFQLTGGVFTRETEVTF-AGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTGPgVLTTSS 157

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450    586 TREYTVteperdgasPSRIYTYQWRQTITFQECVHDDsrPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSP 665
Cdd:smart00682  158 TREYTV---------DNQTHSYTVDQTITFEECQHRD--AFPPTTQQLHVSSVFVDYNDEERVLRFAAHNSVGPGDESNQ 226


                    .
gi 251757450    666 D 666
Cdd:smart00682  227 C 227
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 429-622 5.16e-79

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 257.52  E-value: 5.16e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450   429 GSPQRVNGKVKGRIfvgssqVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNG 508
Cdd:pfam07474    1 GVPQRVNGKVSGTI------NGVEFGDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFALEQGGAKNG 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450   509 FSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVI-TSSSTR 587
Cdd:pfam07474   75 FSLTGGVFNRTAEVTFPPTGERLTITQEFRGLDEDGHLVVDTVISGTVPQVPAGSTVIIEDYTELYQYTGPGElTSSSTR 154

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 251757450   588 EYTVTEPERDgaspsRIYTYQWRQTITFQECVHDD 622
Cdd:pfam07474  155 TYTVDGEGNT-----RTISYTVNQTITYQECRHAE 184
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
106-269 3.11e-45

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 160.29  E-value: 3.11e-45
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450    106 PFLADLDTtDGLGKVYYREDLSPSITQRAAECVHRGFPE-ISFQPSSAVVVTWESVAPYQGPSRDPdqkgkRNTFQAVLA 184
Cdd:smart00539    1 PFWADADT-EGTGKVYYRETTDHAILDRATESVREGFTDmGGFRAKSVVIVTWENVAAYGSQSSDG-----TNTFQAVLA 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450    185 SSDSSSYAIFLYPEDGLQFHTTFSKKenNQVPAVVAFSQGSVGFlwksngAYNIFANDRESVENLAKSSNSGQQGVWVFE 264
Cdd:smart00539   75 TDGSRTYAIFLYPSLGWTSDTTAGGD--DGVRARAGFNGGDGTF------SYTLPASGEENIKNLAEGSNVGIPGRWMFR 146


                    ....*
gi 251757450    265 IGSPA 269
Cdd:smart00539  147 VDGAE 151
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 849-919 1.79e-28

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 108.93  E-value: 1.79e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 251757450   849 CQHEREHILGAAGATDPqrpiPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMtPPC 919
Cdd:pfam00086    1 CERERARALEQAASGRP----ASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGD-PDC 66
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 176-267 5.34e-28

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 108.53  E-value: 5.34e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450   176 RNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENN---QVPAVVAFSQGsvgfLWKSNgAYNIFANDRESVENLAKS 252
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDGGIQWTTGKASGGTNglgGTPAQAGFSAG----DGDGR-YYELPGSGTDSIRNLTET 75

                           90
                   ....*....|....*
gi 251757450   253 SNSGQQGVWVFEIGS 267
Cdd:pfam06119   76 SNVGVPGRWVFRIDS 90
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 849-919 3.94e-25

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 99.46  E-value: 3.94e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 251757450  849 CQHEREHILGAAGatdpqRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGmTPPC 919
Cdd:cd00191     2 CERERASALESLA-----GPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGG-PPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 875-921 8.31e-17

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 75.11  E-value: 8.31e-17
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 251757450    875 VPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTrPGMTPPCLS 921
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRT-EGGDPDCPS 46
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1014-1055 9.55e-14

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 66.47  E-value: 9.55e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 251757450   1014 TIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQR 1055
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 811-839 5.24e-12

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 61.08  E-value: 5.24e-12
                           10        20
                   ....*....|....*....|....*....
gi 251757450   811 CHPDAFCYNTPGSFTCQCKPGYQGDGFRC 839
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1056-1100 2.45e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.54  E-value: 2.45e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 251757450   1056 RVLFETDLVNPRGIVTDSVRGNLYWTDWNRDnpKIETSYMDGTNR 1100
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD--VIEVANLDGTNR 43
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
934-1177 1.17e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 60.80  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  934 PTAVIPLPPGThLLFAQT--GKIERLPLEGNTMRKTEAKAFLHVpakviIGLAFDcVDKMVYWTDITEPSIGRASLHGGE 1011
Cdd:COG4257    19 PRDVAVDPDGA-VWFTDQggGRIGRLDPATGEFTEYPLGGGSGP-----HGIAVD-PDGNLWFTDNGNNRIGRIDPKTGE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1012 PTTI-IRQDLGSPEGIAVDHLGrNIFWTDSNLDRIevAKLDGTQRRVL---FETDLVNPRGIVTDSvRGNLYWTDWNRDN 1087
Cdd:COG4257    92 ITTFaLPGGGSNPHGIAFDPDG-NLWFTDQGGNRI--GRLDPATGEVTefpLPTGGAGPYGIAVDP-DGNLWVTDFGANA 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1088 P-KIETSymDGTNRRILVQDDLGLPNGLTFDAfSSQLCWVDAGTNRAECLNPS--------QPSRRKALEGLqypfAVTS 1158
Cdd:COG4257   168 IgRIDPD--TGTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGSGRIGRFDPKtgtvteypLPGGGARPYGV----AVDG 240

                         250
                  ....*....|....*....
gi 251757450 1159 YGkNLYFTDWKMNSVVALD 1177
Cdd:COG4257   241 DG-RVWFAESGANRIVRFD 258
EGF_CA smart00179
Calcium-binding EGF-like domain;
802-840 1.25e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 54.56  E-value: 1.25e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 251757450    802 DVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQgDGFRCV 840
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 992-1030 2.15e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.09  E-value: 2.15e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 251757450   992 VYWTD-ITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDH 1030
Cdd:pfam00058    3 LYWTDsSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1212-1236 2.73e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 53.40  E-value: 2.73e-09
                           10        20
                   ....*....|....*....|....*
gi 251757450  1212 CSVNNGGCTHLCLATPGSRTCRCPD 1236
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
913-1133 4.83e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 58.17  E-value: 4.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  913 PGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMV 992
Cdd:COG3391     3 VASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  993 YWTDITEPSIGRASLHGGEPTTIIRQDlGSPEGIAVDHLGRNIFWTDSNLDRieVAKLDGTQRRVLFETDL-VNPRGIVT 1071
Cdd:COG3391    83 YVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKVVATIPVgAGPHGIAV 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 251757450 1072 DSVRGNLYWTDWnrDNPKIET--SYMDGTNRRILVQDDLG-LPNGLTFDAFSSQLCWVDAGTNRA 1133
Cdd:COG3391   160 DPDGKRLYVANS--GSNTVSVivSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNTS 222
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 802-840 7.23e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 7.23e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 251757450  802 DVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGDgfRCV 840
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGR--NCE 38
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1019-1176 2.68e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 56.56  E-value: 2.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1019 DLGSPEGIAVDHLGrNIFWTDSNLDRIEVAKLDGTQRRVL-----FETDLVNPRGIVTDSVrGNLYWTDWNRD-----NP 1088
Cdd:cd05819   100 EFNGPRGIAVDSSG-NIYVADTGNHRIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHriqvfDP 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1089 kiETSYMDGTNRRILVQDDLGLPNGLTFDafSSQLCWV-DAGTNRAECLNPSQP------SRRKALEGLQYPF--AVTSY 1159
Cdd:cd05819   178 --DGNFLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYVaDSGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSglAVDSD 253

                         170
                  ....*....|....*..
gi 251757450 1160 GkNLYFTDWKMNSVVAL 1176
Cdd:cd05819   254 G-NLYVADTGNNRIQVF 269
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1033-1072 2.75e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.01  E-value: 2.75e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 251757450  1033 RNIFWTDSNLD-RIEVAKLDGTQRRVLFETDLVNPRGIVTD 1072
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 762-800 2.89e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 50.68  E-value: 2.89e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 251757450   762 CETGLHNCDipQRAQCIYTGGSsYTCSCLPGFSGDGQAC 800
Cdd:pfam12947    1 CSDNNGGCH--PNATCTNTGGS-FTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 390-425 4.27e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 50.29  E-value: 4.27e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 251757450   390 CANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQC 425
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1076-1117 9.53e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 9.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 251757450  1076 GNLYWTDWNRDnPKIETSYMDGTNRRILVQDDLGLPNGLTFD 1117
Cdd:pfam00058    1 GRLYWTDSSLR-ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
EGF_CA smart00179
Calcium-binding EGF-like domain;
710-751 2.72e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 2.72e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 251757450    710 DIDECSEqPSVCGSHTICNNHPGTFRCECVEGYQfsDEGTCV 751
Cdd:smart00179    1 DIDECAS-GNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 672-708 3.34e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 3.34e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 251757450   672 CYIGTHGCDTNAACRPGPrTQFTCECSIGFRGDGRTC 708
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTG-GSFTCTCNDGYTGDGVTC 36
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1020-1177 5.07e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 52.71  E-value: 5.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1020 LGSPEGIAVDHLGrNIFWTDSNLDRIEVAKLDGTQRRV-----LFETDLVNPRGIVTDSvRGNLYWTDWNRDNPKIETSy 1094
Cdd:cd05819    54 FNEPAGVAVDSDG-NLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGNHRIQKFDP- 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1095 mDGTNRRIL-----VQDDLGLPNGLTFDAfSSQLCWVDAGTNRAECLNP------SQPSRRKALEGLQYPF--AVTSYGk 1161
Cdd:cd05819   131 -DGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGNHRIQVFDPdgnfltTFGSTGTGPGQFNYPTgiAVDSDG- 207

                         170
                  ....*....|....*.
gi 251757450 1162 NLYFTDWKMNSVVALD 1177
Cdd:cd05819   208 NIYVADSGNNRVQVFD 223
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1019-1117 5.66e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 52.68  E-value: 5.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1019 DLGSPEGIAVDHLGrNIFWTDSNLDRIEVAKLDGT-----QRRVLFETDLVNPRGIVTDSvRGNLYWTDwNRDNpKIETS 1093
Cdd:cd14963   146 ELSYPNGIAVDEDG-NIYVADSGNGRIQVFDKNGKfikelNGSPDGKSGFVNPRGIAVDP-DGNLYVVD-NLSH-RVYVF 221

                          90       100
                  ....*....|....*....|....*....
gi 251757450 1094 YMDGTNRRILVQ--DDLG---LPNGLTFD 1117
Cdd:cd14963   222 DEQGKELFTFGGrgKDDGqfnLPNGLFID 250
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 805-840 1.92e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 45.55  E-value: 1.92e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 251757450  805 ECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGDgFRCV 840
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGD-RSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 710-743 2.68e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.68e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 251757450  710 DIDECSEqPSVCGSHTICNNHPGTFRCECVEGYQ 743
Cdd:cd00054     1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 982-1011 2.90e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 2.90e-06
                            10        20        30
                    ....*....|....*....|....*....|
gi 251757450    982 GLAFDCVDKMVYWTDITEPSIGRASLHGGE 1011
Cdd:smart00135   13 GLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 989-1177 1.25e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 48.35  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  989 DKMVYWTDITEPSIGRASLHGGEpTTIIRQDLGSPEGIAVDHLGRniFWTDSNLDRIEVAKLDGTQRRVL---FETDLVN 1065
Cdd:COG3386    18 DGRLYWVDIPGGRIHRYDPDGGA-VEVFAEPSGRPNGLAFDPDGR--LLVADHGRGLVRFDPADGEVTVLadeYGKPLNR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1066 PRGIVTDSvRGNLYWTD--WNRDNPKIetSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTN---RAECLNPSQ 1140
Cdd:COG3386    95 PNDGVVDP-DGRLYFTDmgEYLPTGAL--YRVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGriyRFDLDADGT 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 251757450 1141 PSRRKAL----EGLQYP--FAVTSYGkNLYFTDWKMNSVVALD 1177
Cdd:COG3386   172 LGNRRVFadlpDGPGGPdgLAVDADG-NLWVALWGGGGVVRFD 213
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1101-1137 1.29e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.36  E-value: 1.29e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 251757450   1101 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLN 1137
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVAN 37
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 937-1086 1.56e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.97  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  937 VIPLPPGTHllfAQTgkieRLPLEGntmrkteakafLHVPAkviiGLAFDCVDkMVYWTDITEPSIGRASLHGGEPTTII 1016
Cdd:cd14952   117 VLKLAAGSN---TQT----VLPFTG-----------LSNPD----GVAVDGAG-NVYVTDTGNNRVLKLAAGSTTQTVLP 173

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 251757450 1017 RQDLGSPEGIAVDHLGrNIFWTDSNLDRieVAKLD---GTQRRVLFeTDLVNPRGIVTDSvRGNLYWTDWNRD 1086
Cdd:cd14952   174 FTGLNSPSGVAVDTAG-NVYVTDHGNNR--VLKLAagsTTPTVLPF-TGLNGPLGVAVDA-AGNVYVADRGND 241
EGF_CA pfam07645
Calcium-binding EGF domain;
710-741 1.78e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 1.78e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 251757450   710 DIDECSEQPSVCGSHTICNNHPGTFRCECVEG 741
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1012-1177 2.98e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 46.82  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1012 PTTIIRQDLGSPEGIAVDHLGrNIFWTDSNLDRieVAKL--DGTQRRVLFETDLVNPRGIVTDSVrGNLYWTDWnrdnpk 1089
Cdd:cd14952    43 QTVLPFTGLYQPQGVAVDAAG-TVYVTDFGNNR--VLKLaaGSTTQTVLPFTGLNDPTGVAVDAA-GNVYVADT------ 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1090 ietsymdgTNRRILVQ------------DDLGLPNGLTFDAfsSQLCWV-DAGTNRAECLNP--SQPSrrkAL--EGLQY 1152
Cdd:cd14952   113 --------GNNRVLKLaagsntqtvlpfTGLSNPDGVAVDG--AGNVYVtDTGNNRVLKLAAgsTTQT---VLpfTGLNS 179

                         170       180
                  ....*....|....*....|....*..
gi 251757450 1153 PFAVT--SYGkNLYFTDWKMNSVVALD 1177
Cdd:cd14952   180 PSGVAvdTAG-NVYVTDHGNNRVLKLA 205
EGF_CA pfam07645
Calcium-binding EGF domain;
802-831 1.37e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.30  E-value: 1.37e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 251757450   802 DVDECQ--PSRCHPDAFCYNTPGSFTCQCKPG 831
Cdd:pfam07645    1 DVDECAtgTHNCPANTVCVNTIGSFECRCPDG 32
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1019-1176 1.54e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 44.89  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1019 DLGSPEGIAVDHlGRNIFWTDSNLDRieVAKLDG---TQRRVLFeTDLVNPRGIVTDSVrGNLYWTDwnRDNPKIETSYM 1095
Cdd:cd14952    92 GLNDPTGVAVDA-AGNVYVADTGNNR--VLKLAAgsnTQTVLPF-TGLSNPDGVAVDGA-GNVYVTD--TGNNRVLKLAA 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1096 DGTNRRILVQDDLGLPNGLTFDAfSSQLCWVDAGTNRAECLNPSQPSRRK-ALEGLQYP--FAVTSYGkNLYFTDWKMNS 1172
Cdd:cd14952   165 GSTTQTVLPFTGLNSPSGVAVDT-AGNVYVTDHGNNRVLKLAAGSTTPTVlPFTGLNGPlgVAVDAAG-NVYVADRGNDR 242


                  ....
gi 251757450 1173 VVAL 1176
Cdd:cd14952   243 VVKL 246
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
992-1182 2.00e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 2.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450  992 VYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVakLDGTQRRVLFETDL-VNPRGIV 1070
Cdd:COG3391    39 AASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLA 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251757450 1071 TDSVRGNLYWTDWNRDNpkieTSYMDGTNRRILVQDDLGL-PNGLTFDAFSSQLCWVDAGTNRA----ECLNPSQPSRRK 1145
Cdd:COG3391   117 VDPDGGRLYVADSGNGR----VSVIDTATGKVVATIPVGAgPHGIAVDPDGKRLYVANSGSNTVsvivSVIDTATGKVVA 192

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 251757450 1146 ALEGLQYPF--AVTSYGKNLYFTDWKMNSVVALDLAISK 1182
Cdd:COG3391   193 TIPVGGGPVgvAVSPDGRRLYVANRGSNTSNGGSNTVSV 231
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 806-835 3.96e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 3.96e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 251757450   806 CQPSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF smart00181
Epidermal growth factor-like domain;
805-840 9.53e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.88  E-value: 9.53e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 251757450    805 ECQPSR-CHPDaFCYNTPGSFTCQCKPGYQGDGfRCV 840
Cdd:smart00181    1 ECASGGpCSNG-TCINTPGSYTCSCPPGYTGDK-RCE 35
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 714-743 2.77e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.42  E-value: 2.77e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 251757450   714 CSEQPSVCGSHTICNNHPGTFRCECVEGYQ 743
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYT 30
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 713-743 5.08e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 5.08e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 251757450  713 ECSeQPSVCGSHTICNNHPGTFRCECVEGYQ 743
Cdd:cd00053     1 ECA-ASNPCSNGGTCVNTPGSYRCVCPPGYT 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
759-801 5.94e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 5.94e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 251757450    759 INYCETGlHNCDipQRAQCIYTGGSsYTCSCLPGFSgDGQACQ 801
Cdd:smart00179    2 IDECASG-NPCQ--NGGTCVNTVGS-YRCECPPGYT-DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 390-426 6.91e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 251757450  390 CANNrHQCSVHAECRDYATGFCCSCVAGYTgnGRQCV 426
Cdd:cd00054     5 CASG-NPCQNGGTCVNTVGSYRCSCPPGYT--GRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 393-421 8.50e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 8.50e-03
                           10        20
                   ....*....|....*....|....*....
gi 251757450   393 NRHQCSVHAECRDYATGFCCSCVAGYTGN 421
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGK 30
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 786-805 8.70e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 34.69  E-value: 8.70e-03
                           10        20
                   ....*....|....*....|..
gi 251757450   786 TCSCLPGFSG--DGQACQDVDE 805
Cdd:pfam12662    1 TCSCPPGYQLdpDGRTCVDIDE 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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