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Conserved domains on  [gi|2506782|sp|P16506|]
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RecName: Full=RNA-directed RNA polymerase catalytic subunit; AltName: Full=Polymerase basic protein 1; Short=PB1; AltName: Full=RNA-directed RNA polymerase subunit P1

Protein Classification

RNA-directed RNA polymerase catalytic subunit( domain architecture ID 10457089)

RNA-directed RNA polymerase catalytic subunit is responsible for replication and transcription of virus RNA segments

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Flu_PB1 pfam00602
Influenza RNA-dependent RNA polymerase subunit PB1; Two GTP binding sites exist in this ...
1-740 0e+00

Influenza RNA-dependent RNA polymerase subunit PB1; Two GTP binding sites exist in this protein.


:

Pssm-ID: 395479  Cd Length: 732  Bit Score: 1254.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782      1 MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPED--NE 78
Cdd:pfam00602   1 MEINPYLLFLDVPIQAAISTTYPYTGPPPYSHGTGTGYTLETIIRTYQYSEKGVQYTSDVTGCPMVDPTNCPEPEDivNE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782     79 PSGYAQTDCVLEAMAFLEESH-PGIFENSCLETMEVIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNgLTA 157
Cdd:pfam00602  81 PSGYAQTDSVLELADRMEEEHrPGLFEALSQEAMEALMKTTVDKLTQGRQTYDWTVCRNQPAATALNTTVESFRLN-LNG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    158 NESGRLIDFLKDVIESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLK 237
Cdd:pfam00602 160 ADGGTLLPYCQDIIDSLDKPEMTFFTVKNIKRREPDKNRKKFLIKRVPMKVKDRIKRVEYLIRALTLNTMTKDAERGKLK 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    238 RRAIATPGMQIRGFVHFVETLARNICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRV 317
Cdd:pfam00602 240 RRAIATPGMQIRGFVKIVETLAKNICENLEQSGLPVGGNEKKAKLANAVAKMLSNCPPTGISMTITGDNTKWNECLNPRA 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    318 FLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEmlasiDLKYFNESTRKKIEKIRPL-L 396
Cdd:pfam00602 320 FLAMTTYITRDSPDWFRDLCSIAPVLFSNKIARLGKGFMITSKTKTLRAQIPAE-----PLERYNDLTRAKLKNLKPLfN 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    397 IDGTVSLSPGMMMGMFNMLSTVLGVSILnlGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVNRFYRTCKLVGIN 476
Cdd:pfam00602 395 EEGTASLSPGMMMGMFNMLSTVLGVSAL--GIEELTNKEYLWDGLQSSDDFALFVNAKNHETIMEGINRFYRTCKLLGIN 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    477 MSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYR 556
Cdd:pfam00602 473 MSKKKSYISETGMFEFTSMFYRDGFVSNFAMELPAFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQMALRIFIADYR 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    557 YTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGSNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKe 636
Cdd:pfam00602 553 YTYRCHRGDSKVEGRRMKIIKELWENTKGKDGLLVADGGPNLYNISTLHIPEVVLKYELMDEEYKGRLLNPQNPFTGHL- 631
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    637 iesvNNAVVMPAHGPAKSMEYDAVATTHSWTPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVE 716
Cdd:pfam00602 632 ----KEADIFRAHGPIKKMEYDAVSSTHSWRTKRNRTILNTDQRAMLLEEQRYQRVCNLFEKCFPSASIRKPVGQHSMLE 707
                         730       740
                  ....*....|....*....|....
gi 2506782    717 AMVSRARIDARIDFESGRIKKEEF 740
Cdd:pfam00602 708 AMAHRLRERARLDYESGRISKEEF 731
 
Name Accession Description Interval E-value
Flu_PB1 pfam00602
Influenza RNA-dependent RNA polymerase subunit PB1; Two GTP binding sites exist in this ...
1-740 0e+00

Influenza RNA-dependent RNA polymerase subunit PB1; Two GTP binding sites exist in this protein.


Pssm-ID: 395479  Cd Length: 732  Bit Score: 1254.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782      1 MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPED--NE 78
Cdd:pfam00602   1 MEINPYLLFLDVPIQAAISTTYPYTGPPPYSHGTGTGYTLETIIRTYQYSEKGVQYTSDVTGCPMVDPTNCPEPEDivNE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782     79 PSGYAQTDCVLEAMAFLEESH-PGIFENSCLETMEVIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNgLTA 157
Cdd:pfam00602  81 PSGYAQTDSVLELADRMEEEHrPGLFEALSQEAMEALMKTTVDKLTQGRQTYDWTVCRNQPAATALNTTVESFRLN-LNG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    158 NESGRLIDFLKDVIESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLK 237
Cdd:pfam00602 160 ADGGTLLPYCQDIIDSLDKPEMTFFTVKNIKRREPDKNRKKFLIKRVPMKVKDRIKRVEYLIRALTLNTMTKDAERGKLK 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    238 RRAIATPGMQIRGFVHFVETLARNICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRV 317
Cdd:pfam00602 240 RRAIATPGMQIRGFVKIVETLAKNICENLEQSGLPVGGNEKKAKLANAVAKMLSNCPPTGISMTITGDNTKWNECLNPRA 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    318 FLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEmlasiDLKYFNESTRKKIEKIRPL-L 396
Cdd:pfam00602 320 FLAMTTYITRDSPDWFRDLCSIAPVLFSNKIARLGKGFMITSKTKTLRAQIPAE-----PLERYNDLTRAKLKNLKPLfN 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    397 IDGTVSLSPGMMMGMFNMLSTVLGVSILnlGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVNRFYRTCKLVGIN 476
Cdd:pfam00602 395 EEGTASLSPGMMMGMFNMLSTVLGVSAL--GIEELTNKEYLWDGLQSSDDFALFVNAKNHETIMEGINRFYRTCKLLGIN 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    477 MSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYR 556
Cdd:pfam00602 473 MSKKKSYISETGMFEFTSMFYRDGFVSNFAMELPAFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQMALRIFIADYR 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    557 YTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGSNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKe 636
Cdd:pfam00602 553 YTYRCHRGDSKVEGRRMKIIKELWENTKGKDGLLVADGGPNLYNISTLHIPEVVLKYELMDEEYKGRLLNPQNPFTGHL- 631
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    637 iesvNNAVVMPAHGPAKSMEYDAVATTHSWTPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVE 716
Cdd:pfam00602 632 ----KEADIFRAHGPIKKMEYDAVSSTHSWRTKRNRTILNTDQRAMLLEEQRYQRVCNLFEKCFPSASIRKPVGQHSMLE 707
                         730       740
                  ....*....|....*....|....
gi 2506782    717 AMVSRARIDARIDFESGRIKKEEF 740
Cdd:pfam00602 708 AMAHRLRERARLDYESGRISKEEF 731
 
Name Accession Description Interval E-value
Flu_PB1 pfam00602
Influenza RNA-dependent RNA polymerase subunit PB1; Two GTP binding sites exist in this ...
1-740 0e+00

Influenza RNA-dependent RNA polymerase subunit PB1; Two GTP binding sites exist in this protein.


Pssm-ID: 395479  Cd Length: 732  Bit Score: 1254.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782      1 MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPED--NE 78
Cdd:pfam00602   1 MEINPYLLFLDVPIQAAISTTYPYTGPPPYSHGTGTGYTLETIIRTYQYSEKGVQYTSDVTGCPMVDPTNCPEPEDivNE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782     79 PSGYAQTDCVLEAMAFLEESH-PGIFENSCLETMEVIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNgLTA 157
Cdd:pfam00602  81 PSGYAQTDSVLELADRMEEEHrPGLFEALSQEAMEALMKTTVDKLTQGRQTYDWTVCRNQPAATALNTTVESFRLN-LNG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    158 NESGRLIDFLKDVIESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLK 237
Cdd:pfam00602 160 ADGGTLLPYCQDIIDSLDKPEMTFFTVKNIKRREPDKNRKKFLIKRVPMKVKDRIKRVEYLIRALTLNTMTKDAERGKLK 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    238 RRAIATPGMQIRGFVHFVETLARNICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRV 317
Cdd:pfam00602 240 RRAIATPGMQIRGFVKIVETLAKNICENLEQSGLPVGGNEKKAKLANAVAKMLSNCPPTGISMTITGDNTKWNECLNPRA 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    318 FLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEmlasiDLKYFNESTRKKIEKIRPL-L 396
Cdd:pfam00602 320 FLAMTTYITRDSPDWFRDLCSIAPVLFSNKIARLGKGFMITSKTKTLRAQIPAE-----PLERYNDLTRAKLKNLKPLfN 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    397 IDGTVSLSPGMMMGMFNMLSTVLGVSILnlGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVNRFYRTCKLVGIN 476
Cdd:pfam00602 395 EEGTASLSPGMMMGMFNMLSTVLGVSAL--GIEELTNKEYLWDGLQSSDDFALFVNAKNHETIMEGINRFYRTCKLLGIN 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    477 MSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYR 556
Cdd:pfam00602 473 MSKKKSYISETGMFEFTSMFYRDGFVSNFAMELPAFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQMALRIFIADYR 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    557 YTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGSNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKe 636
Cdd:pfam00602 553 YTYRCHRGDSKVEGRRMKIIKELWENTKGKDGLLVADGGPNLYNISTLHIPEVVLKYELMDEEYKGRLLNPQNPFTGHL- 631
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    637 iesvNNAVVMPAHGPAKSMEYDAVATTHSWTPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVE 716
Cdd:pfam00602 632 ----KEADIFRAHGPIKKMEYDAVSSTHSWRTKRNRTILNTDQRAMLLEEQRYQRVCNLFEKCFPSASIRKPVGQHSMLE 707
                         730       740
                  ....*....|....*....|....
gi 2506782    717 AMVSRARIDARIDFESGRIKKEEF 740
Cdd:pfam00602 708 AMAHRLRERARLDYESGRISKEEF 731
Bunya_RdRp pfam04196
Bunyavirus RNA dependent RNA polymerase; The bunyaviruses are enveloped viruses with a genome ...
255-500 2.83e-03

Bunyavirus RNA dependent RNA polymerase; The bunyaviruses are enveloped viruses with a genome consisting of 3 ssRNA segments (called L, M and S). The nucleocapsid protein is encode on the small (S) genomic RNA. The L segment codes for an RNA polymerase. This family contains the RNA dependent RNA polymerase on the L segment.


Pssm-ID: 282102  Cd Length: 739  Bit Score: 41.30  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    255 VETLARNICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGD--NTKWNEnqnprvflamITYITRNQPEW 332
Cdd:pfam04196 375 VERISRAILKLNPSEMISEPKDKKILAISEKHEMEARWTVEDTFKTLSTSDdaISKKNQ----------LMHVSADMSKW 444
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    333 ------FRNVLSIAPI-MFSNKMARLGKGYM--FESKSM-----KLRTQIPAEMLASIDLKYFNESTRKKiekirpllid 398
Cdd:pfam04196 445 sasdltYKYFFLIALLpILYPKEKFLGLYLLcnYMSKTDllpsdILLNLVDQKYYGRYDIIFWMTNGLNK---------- 514
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506782    399 GTVSLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTTYWWDG------LQSSDDFALIVNAPNHegIQAGVNRFYRTC-- 470
Cdd:pfam04196 515 NFVEVKRNWLQGNLNYTSSLVHSCAMEVYKEFLKRAIKLLDGsclvnsIVHSDDSQTSISIPCH--VDDKQADFKSVLva 592
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2506782    471 -----------KLVGINMSKKKSYINRTgTFEFTSFFYRYG 500
Cdd:pfam04196 593 nsafrskelifKYLCIYASPKKTYVTLT-VKEFNSEFFFSG 632
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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