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Conserved domains on  [gi|2498866|sp|Q15404|]
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RecName: Full=Ras suppressor protein 1; Short=RSP-1; Short=Rsu-1

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-205 9.41e-38

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.37  E-value: 9.41e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   34 NGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866  114 LDLTYNNLSEnsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886 187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263

                       170
                ....*....|..
gi 2498866  194 VLPPELGNLDLT 205
Cdd:COG4886 264 DLPPLANLTNLK 275
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-205 9.41e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.37  E-value: 9.41e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   34 NGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866  114 LDLTYNNLSEnsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886 187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263

                       170
                ....*....|..
gi 2498866  194 VLPPELGNLDLT 205
Cdd:COG4886 264 DLPPLANLTNLK 275
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-200 8.50e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 8.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866    34 NGLFTLSHITQLVLSHNKLT-MVPPNIAELKNLEVLNF-FNNQIEELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPA 110
Cdd:PLN00113 182 NSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKN 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   111 LEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDNDF--EIlPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHI 187
Cdd:PLN00113 262 LQYLFLYQNKLS-GPIPPSIFSLQKLISLDLSDNSLsgEI-PELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQL 339

                        170
                 ....*....|....
gi 2498866   188 QGNRLT-VLPPELG 200
Cdd:PLN00113 340 WSNKFSgEIPKNLG 353
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-206 5.65e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 5.65e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   42 ITQLVLSHNKLTMVPpNIAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLPrGFGSLPALEVLDLTYNNL 121
Cdd:cd21340   4 ITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866  122 SENSlpgNFFYLTTLRALYLSDNDfeiLPPDiGKLTK-----------LQILSLRDNDLISLpKEIGELTQLKELHIQGN 190
Cdd:cd21340  81 SVVE---GLENLTNLEELHIENQR---LPPG-EKLTFdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNN 152

                       170       180
                ....*....|....*....|....*
gi 2498866  191 RLTVLP---------PELGNLDLTG 206
Cdd:cd21340 153 QISDLEelldllsswPSLRELDLTG 177
LRR_8 pfam13855
Leucine rich repeat;
64-121 1.58e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 1.58e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866     64 NLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMNRLNTL-PRGFGSLPALEVLDLTYNNL 121
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-205 9.41e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.37  E-value: 9.41e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   34 NGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866  114 LDLTYNNLSEnsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886 187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263

                       170
                ....*....|..
gi 2498866  194 VLPPELGNLDLT 205
Cdd:COG4886 264 DLPPLANLTNLK 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-202 3.86e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 3.86e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNl 121
Cdd:COG4886  29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866  122 senslpgNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 201
Cdd:COG4886 108 -------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGN 180


                .
gi 2498866  202 L 202
Cdd:COG4886 181 L 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-200 8.50e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 8.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866    34 NGLFTLSHITQLVLSHNKLT-MVPPNIAELKNLEVLNF-FNNQIEELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPA 110
Cdd:PLN00113 182 NSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKN 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   111 LEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDNDF--EIlPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHI 187
Cdd:PLN00113 262 LQYLFLYQNKLS-GPIPPSIFSLQKLISLDLSDNSLsgEI-PELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQL 339

                        170
                 ....*....|....
gi 2498866   188 QGNRLT-VLPPELG 200
Cdd:PLN00113 340 WSNKFSgEIPKNLG 353
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-202 2.09e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.88  E-value: 2.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866    40 SHITQLVLSHNKLT-MVPPNIAELKNLEVLNFFNNQIE-ELPTQISSL-QKLKHLNLGMNRLN-TLPRGFgsLPALEVLD 115
Cdd:PLN00113  69 SRVVSIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTgSIPRGS--IPNLETLD 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   116 LTyNNLSENSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI------------------------ 170
Cdd:PLN00113 147 LS-NNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnls 225

                        170       180       190
                 ....*....|....*....|....*....|....
gi 2498866   171 -SLPKEIGELTQLKELHIQGNRLT-VLPPELGNL 202
Cdd:PLN00113 226 gEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNL 259
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-193 3.26e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.41  E-value: 3.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866    34 NGLFTLSHITQLVLSHNKLT-MVPPNIAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPA 110
Cdd:PLN00113 278 PSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNN 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   111 LEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQ 188
Cdd:PLN00113 358 LTVLDLSTNNLT-GEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDIS 436


                 ....*
gi 2498866   189 GNRLT 193
Cdd:PLN00113 437 NNNLQ 441
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-217 5.89e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.49  E-value: 5.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866    31 LDVNGLFTL-----SHITQLVLSHNKLTMVPPNIAElkNLEVLNFFNNQIEELPTQISSlqKLKHLNLGMNRLNTLPRGF 105
Cdd:PRK15370 248 LSINRITELperlpSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETL 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   106 GslPALEVLDLTYNNLSenSLPGNFfyLTTLRALYLSDNDFEILPPDIGKltKLQILSLRDNDLISLPKEIGelTQLKEL 185
Cdd:PRK15370 324 P--PGLKTLEAGENALT--SLPASL--PPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLP--AALQIM 393

                        170       180       190
                 ....*....|....*....|....*....|...
gi 2498866   186 HIQGNRLTVLPPELGNLDLTG-QKQVFKAENNP 217
Cdd:PRK15370 394 QASRNNLVRLPESLPHFRGEGpQPTRIIVEYNP 426
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
34-196 8.39e-12

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 65.18  E-value: 8.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866    34 NGLFTL-----SHITQLVLSHNKLTMVPPNIAELKNLEV-----------------LNFFNNQIEELPTQISSLQKLKHL 91
Cdd:PRK15387 211 SGLTTLpdclpAHITTLVIPDNNLTSLPALPPELRTLEVsgnqltslpvlppglleLSIFSNPLTHLPALPSGLCKLWIF 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866    92 NLGMNRLNTLPRGF----------GSLPAL--EVLDLTYNNLSENSLPGnffYLTTLRALYLSDNDFEILPPDIGKLTKL 159
Cdd:PRK15387 291 GNQLTSLPVLPPGLqelsvsdnqlASLPALpsELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKL 367

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 2498866   160 QILSLRDNDLISLPKEIGEL--------------TQLKELHIQGNRLTVLP 196
Cdd:PRK15387 368 WAYNNRLTSLPALPSGLKELivsgnrltslpvlpSELKELMVSGNRLTSLP 418
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-208 1.33e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.48  E-value: 1.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866    40 SHITQLVLSHNKLT-MVPPNIAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDL 116
Cdd:PLN00113 356 NNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDI 435

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   117 TYNNLSENsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT-V 194
Cdd:PLN00113 436 SNNNLQGR-INSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgE 514

                        170       180
                 ....*....|....*....|
gi 2498866   195 LPPELG------NLDLTGQK 208
Cdd:PLN00113 515 IPDELSsckklvSLDLSHNQ 534
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-206 5.65e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 5.65e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   42 ITQLVLSHNKLTMVPpNIAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLPrGFGSLPALEVLDLTYNNL 121
Cdd:cd21340   4 ITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866  122 SENSlpgNFFYLTTLRALYLSDNDfeiLPPDiGKLTK-----------LQILSLRDNDLISLpKEIGELTQLKELHIQGN 190
Cdd:cd21340  81 SVVE---GLENLTNLEELHIENQR---LPPG-EKLTFdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNN 152

                       170       180
                ....*....|....*....|....*
gi 2498866  191 RLTVLP---------PELGNLDLTG 206
Cdd:cd21340 153 QISDLEelldllsswPSLRELDLTG 177
PLN03150 PLN03150
hypothetical protein; Provisional
 78-144 1.10e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 61.76  E-value: 1.10e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2498866    78 LPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDN 144
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFN-GSIPESLGQLTSLRILNLNGN 500
PLN03150 PLN03150
hypothetical protein; Provisional
 51-217 4.35e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.83  E-value: 4.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866    51 KLTMVPP--NIAELKNLEVLNFFNNQIEELPTQISSLQKLKH-----LNLGMNRLNTLPR---------GFGSLPALEVL 114
Cdd:PLN03150 341 TIVLQPKkgTHAIINAIEVFEIITAESKTLLEEVSALQTLKSslglpLRFGWNGDPCVPQqhpwsgadcQFDSTKGKWFI 420

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   115 D-LTYNNLS-ENSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGN 190
Cdd:PLN03150 421 DgLGLDNQGlRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500

                        170       180
                 ....*....|....*....|....*...
gi 2498866   191 RLT-VLPPELGNLDLTGQKqvFKAENNP 217
Cdd:PLN03150 501 SLSgRVPAALGGRLLHRAS--FNFTDNA 526
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 11-170 1.42e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 1.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866    11 ESREKNQPEVDMSDRGISNML-DVNGLFTLSHITQLVLSHNKLT-MVPPNIAELKNLEVLNFFNNQIE-ELPTQISSLQK 87
Cdd:PLN00113 445 NSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKK 524

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866    88 LKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRD 166
Cdd:PLN00113 525 LVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLS-GEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAG 603


                 ....
gi 2498866   167 NDLI 170
Cdd:PLN00113 604 NIDL 607
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 35-174 3.17e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 3.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   35 GLFTLSHITQLVLSHNKLTMVpPNIAELKNLEVLNFFNNQIEELpTQISSLQKLKHLNLGMNRlntLPRG---------- 104
Cdd:cd21340  41 NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQR---LPPGekltfdprsl 115

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2498866  105 FGSLPALEVLDLTYNNLSEnslPGNFFYLTTLRALYLSDN---DFEILPPDIGKLTKLQILSLRDNDLISLPK 174
Cdd:cd21340 116 AALSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
64-121 1.58e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 1.58e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866     64 NLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMNRLNTL-PRGFGSLPALEVLDLTYNNL 121
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-146 1.66e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 1.66e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2498866     86 QKLKHLNLGMNRLNTLPRG-FGSLPALEVLDLTYNNLSENSlPGNFFYLTTLRALYLSDNDF 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
40-193 1.77e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.92  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866    40 SHITQLVLSHNKLTMVPPNIAELKNLEVlnfFNNQIEELPTQISSLQKLKHLNlgmNRLNTLPrgfgSLPA-LEVLDLTY 118
Cdd:PRK15387 322 SELCKLWAYNNQLTSLPTLPSGLQELSV---SDNQLASLPTLPSELYKLWAYN---NRLTSLP----ALPSgLKELIVSG 391

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2498866   119 NNLSenSLPgnfFYLTTLRALYLSDNDFEILP--PdigklTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLT 193
Cdd:PRK15387 392 NRLT--SLP---VLPSELKELMVSGNRLTSLPmlP-----SGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLS 458
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 52-182 4.56e-05

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 44.87  E-value: 4.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866     52 LTMVPPNIAELknlevlnFFNN--QIEELPTQISSLQKLKHLNLgMN--RLNTLPRGFgSLPALEVLDL-------TYNN 120
Cdd:PLN03210  773 MTMLSPSLTRL-------FLSDipSLVELPSSIQNLHKLEHLEI-ENciNLETLPTGI-NLESLESLDLsgcsrlrTFPD 843

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2498866    121 LSENslpgnffylttLRALYLSDNDFEILPPDIGKLTKLQILSLRD-NDLISLPKEIGELTQL 182
Cdd:PLN03210  844 ISTN-----------ISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHL 895
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 80-193 8.96e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 8.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   80 TQISSLQKLKHLN--LGMNRLNTLPRGFGSL-PALEVLDLTYNNLSENS---LPGNFFYLTTLRALYLSDND-----FEI 148
Cdd:cd00116 105 LRSSSLQELKLNNngLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASceaLAKALRANRDLKELNLANNGigdagIRA 184

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 2498866  149 LPPDIGKLTKLQILSLRDNDL-----ISLPKEIGELTQLKELHIQGNRLT 193
Cdd:cd00116 185 LAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLT 234
LRR_8 pfam13855
Leucine rich repeat;
109-169 1.40e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2498866    109 PALEVLDLTYNNLSENSlPGNFFYLTTLRALYLSDNDFEILPPD-IGKLTKLQILSLRDNDL 169
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 40-193 3.84e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 3.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   40 SHITQLVLSHNKLTMVP-PNIAEL----KNLEVLNFFNNQIEE-----LPTQISSLQKLKHLNLGMNRLN-----TLPRG 104
Cdd:cd00116 137 PALEKLVLGRNRLEGAScEALAKAlranRDLKELNLANNGIGDagiraLAEGLKANCNLEVLDLNNNGLTdegasALAET 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866  105 FGSLPALEVLDLTYNNLSENSL----PGNFFYLTTLRALYLSDNDfeilppdigkltklqilsLRDNDLISLPKEIGELT 180
Cdd:cd00116 217 LASLKSLEVLNLGDNNLTDAGAaalaSALLSPNISLLTLSLSCND------------------ITDDGAKDLAEVLAEKE 278

                       170
                ....*....|...
gi 2498866  181 QLKELHIQGNRLT 193
Cdd:cd00116 279 SLLELDLRGNKFG 291
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 21-210 1.69e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866     21 DMSDRGISNMLDVNGLFTLSHITQLVLSH-NKLTMVPPNIAELKNLEVLNF-FNNQIEELPTQISsLQKLKHLNL-GMNR 97
Cdd:PLN03210  638 NIDLRGSKNLKEIPDLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLDMsRCENLEILPTGIN-LKSLYRLNLsGCSR 716

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866     98 LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLT--TLRALYLSDND------FEILPPDIGKLTKLQILSLrdndl 169
Cdd:PLN03210  717 LKSFPDISTNISWLDLDETAIEEFPSNLRLENLDELIlcEMKSEKLWERVqpltplMTMLSPSLTRLFLSDIPSL----- 791

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2498866    170 ISLPKEIGELTQLKELHIQGNR-LTVLP-----PELGNLDLTGQKQV 210
Cdd:PLN03210  792 VELPSSIQNLHKLEHLEIENCInLETLPtginlESLESLDLSGCSRL 838
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-210 2.69e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 2.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   32 DVNGLFTLSHITQLVLSHNKLTMVPPnIAELKNLEVLNFFNNQIEELptqisSLQKLKHLNLGMNRLNTLPRGFGSLPAL 111
Cdd:COG4886 242 DLPELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLELLI 315

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866  112 EVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNR 191
Cdd:COG4886 316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395

                       170
                ....*....|....*....
gi 2498866  192 LTVLPPELGNLDLTGQKQV 210
Cdd:COG4886 396 TTAGVLLLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 32-115 2.82e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 2.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   32 DVNGLFTLSH-ITQLVLSHNKLTMVPPnIAELKNLEVLNFFNNQI---EELPTQISSLQKLKHLNLGMNRLNTLPRGFGS 107
Cdd:cd21340 111 DPRSLAALSNsLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQIsdlEELLDLLSSWPSLRELDLTGNPVCKKPKYRDK 189

                        90
                ....*....|..
gi 2498866  108 L----PALEVLD 115
Cdd:cd21340 190 IilasKSLEVLD 201
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 60-195 6.22e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 37.85  E-value: 6.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866   60 AELKNLEVLNFFNNQI-----EELPTQISSLQKLKHLNLGMNRLN-----TLPRGFGSLPALEVLDLTYNNLSE------ 123
Cdd:COG5238 233 KGNKSLTTLDLSNNQIgdegvIALAEALKNNTTVETLYLSGNQIGaegaiALAKALQGNTTLTSLDLSVNRIGDegaial 312

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498866  124 -NSLPGNffylTTLRALYLSDNDF-----EILPPDIGKLTKLQILSLRDNDL-----ISLPKEIGELTQLKELHIQGNRL 192
Cdd:COG5238 313 aEGLQGN----KTLHTLNLAYNGIgaqgaIALAKALQENTTLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNI 388


                ...
gi 2498866  193 TVL 195
Cdd:COG5238 389 GKQ 391
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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