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Conserved domains on  [gi|2497534|sp|Q55863|]
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RecName: Full=Pyruvate kinase 1; Short=PK 1

Protein Classification

pyruvate kinase( domain architecture ID 11422070)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  2379684|12798932|10751408|31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 16-482 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 727.21  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   16 HRTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGE 95
Cdd:COG0469   3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   96 KQLREGEKVSLVPVEI-GDRHpgAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRKGVNLP 174
Cdd:COG0469  83 VELKKGDTFTLTTDDVeGDAE--RVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  175 GLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHpDLPVIAKIEKPQAIDNLEEIVAVSNGIM 254
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEASDGIM 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  255 VARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVGQYP 334
Cdd:COG0469 240 VARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYP 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  335 VKSVQMLRKIAEETE-----VGLHLVNNPPIENTETHALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSVPVIAF 409
Cdd:COG0469 320 VEAVETMARIAEEAEksldyRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILAL 399

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2497534  410 TPSEKVYHSLNLVWGIIPFLInEEFDTFEDLIQQAEVLLRDRKMVEKGDQLLIMAGIPTKIPRGTNFLKIHRI 482
Cdd:COG0469 400 TPNERTARRLALVWGVYPVLV-DDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
 
Name Accession Description Interval E-value
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 16-482 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 727.21  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   16 HRTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGE 95
Cdd:COG0469   3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   96 KQLREGEKVSLVPVEI-GDRHpgAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRKGVNLP 174
Cdd:COG0469  83 VELKKGDTFTLTTDDVeGDAE--RVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  175 GLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHpDLPVIAKIEKPQAIDNLEEIVAVSNGIM 254
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEASDGIM 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  255 VARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVGQYP 334
Cdd:COG0469 240 VARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYP 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  335 VKSVQMLRKIAEETE-----VGLHLVNNPPIENTETHALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSVPVIAF 409
Cdd:COG0469 320 VEAVETMARIAEEAEksldyRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILAL 399

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2497534  410 TPSEKVYHSLNLVWGIIPFLInEEFDTFEDLIQQAEVLLRDRKMVEKGDQLLIMAGIPTKIPRGTNFLKIHRI 482
Cdd:COG0469 400 TPNERTARRLALVWGVYPVLV-DDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 16-479 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 683.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534     16 HRTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGE 95
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534     96 KQLREGEKVSLVP-VEIGDRHPGAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRKGVNLP 174
Cdd:TIGR01064  81 VKLKKGDKVIITTdDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    175 GLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHPDLPVIAKIEKPQAIDNLEEIVAVSNGIM 254
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    255 VARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVGQYP 334
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    335 VKSVQMLRKIAEETEVGLHLVNNPP-------IENTETHALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSVPVI 407
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFNdrknsdpKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2497534    408 AFTPSEKVYHSLNLVWGIIPFLINEEFDTFEDLIQQAEVLLRDRKMVEKGDQLLIMAGIPTKIPRGTNFLKI 479
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
PRK05826 PRK05826
pyruvate kinase; Provisional
 15-467 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 582.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    15 SHRTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGG 94
Cdd:PRK05826   3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    95 EKQLREGEKVSLV--PVEIGDRhpGAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRKGVN 172
Cdd:PRK05826  83 KITLKTGDKFTLDtdQKEEGDK--ERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   173 LPGLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHPDLPVIAKIEKPQAIDNLEEIVAVSNG 252
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   253 IMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVGQ 332
Cdd:PRK05826 241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   333 YPVKSVQMLRKIAEETE------VGLHLVNNPPIENTETHALSeALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSVPV 406
Cdd:PRK05826 321 YPVEAVEAMARICKGAEkefsinLSKHRLDRQFDRIDEAIAMS-AMYAANHLKGVKAIVALTESGRTARLISRFRPGAPI 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2497534   407 IAFTPSEKVYHSLNLVWGIIPFLINEEFDTfEDLIQQAEVLLRDRKMVEKGDQLLIMAGIP 467
Cdd:PRK05826 400 FAVTRDEKTQRRLALYRGVYPVLFDSAADT-DDAAEEALRLLLEKGLVESGDLVVVTSGDP 459
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 17-482 2.80e-168

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 482.97  E-value: 2.80e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   17 RTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGEK 96
Cdd:cd00288   3 RTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGKD 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   97 -QLREGEKVSLV---PVEIGDrhPGAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDP-EVICEVVTGGILKSRKGV 171
Cdd:cd00288  83 iSLKAGDKFLVTtdpAAKKGT--KEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKGV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  172 NLPGLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHpDLPVIAKIEKPQAIDNLEEIVAVSN 251
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGK-DIKIIAKIENQEGVNNFDEILEASD 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  252 GIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVG 331
Cdd:cd00288 240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  332 QYPVKSVQMLRKIAEETEVGLH-------LVNNPPIENTETHALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSV 404
Cdd:cd00288 320 KYPVEAVKAMARICLEAEKALShrvlfneMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  405 PVIAFTPSEKVYHSLNLVWGIIPFLINEEFDTF----EDLIQQAEVLLRDRKMVEKGDQLLIMAGIPTKIPRgTNFLKIH 480
Cdd:cd00288 400 PIIAVTRNEQTARQLHLYRGVYPVLFEEPKPGWqedtDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGS-TNTMRIL 478


                ..
gi 2497534  481 RI 482
Cdd:cd00288 479 TV 480
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 17-352 2.73e-137

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 399.05  E-value: 2.73e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534     17 RTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGEK 96
Cdd:pfam00224   3 RTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGKK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534     97 --QLREGEK--VSLVPVEIGDRHPGAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPE-VICEVVTGGILKSRKGV 171
Cdd:pfam00224  83 diELKAGDEmiVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRKGV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    172 NLPGLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHpDLPVIAKIEKPQAIDNLEEIVAVSN 251
Cdd:pfam00224 163 NLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGK-NIQIIAKIENQEGVNNFDEILEATD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    252 GIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVG 331
Cdd:pfam00224 242 GIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 321

                         330       340
                  ....*....|....*....|.
gi 2497534    332 QYPVKSVQMLRKIAEETEVGL 352
Cdd:pfam00224 322 NYPVEAVRMMHEICLEAEKAL 342
 
Name Accession Description Interval E-value
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 16-482 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 727.21  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   16 HRTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGE 95
Cdd:COG0469   3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   96 KQLREGEKVSLVPVEI-GDRHpgAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRKGVNLP 174
Cdd:COG0469  83 VELKKGDTFTLTTDDVeGDAE--RVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  175 GLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHpDLPVIAKIEKPQAIDNLEEIVAVSNGIM 254
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEASDGIM 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  255 VARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVGQYP 334
Cdd:COG0469 240 VARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYP 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  335 VKSVQMLRKIAEETE-----VGLHLVNNPPIENTETHALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSVPVIAF 409
Cdd:COG0469 320 VEAVETMARIAEEAEksldyRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILAL 399

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2497534  410 TPSEKVYHSLNLVWGIIPFLInEEFDTFEDLIQQAEVLLRDRKMVEKGDQLLIMAGIPTKIPRGTNFLKIHRI 482
Cdd:COG0469 400 TPNERTARRLALVWGVYPVLV-DDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 16-479 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 683.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534     16 HRTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGE 95
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534     96 KQLREGEKVSLVP-VEIGDRHPGAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRKGVNLP 174
Cdd:TIGR01064  81 VKLKKGDKVIITTdDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    175 GLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHPDLPVIAKIEKPQAIDNLEEIVAVSNGIM 254
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    255 VARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVGQYP 334
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    335 VKSVQMLRKIAEETEVGLHLVNNPP-------IENTETHALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSVPVI 407
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFNdrknsdpKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2497534    408 AFTPSEKVYHSLNLVWGIIPFLINEEFDTFEDLIQQAEVLLRDRKMVEKGDQLLIMAGIPTKIPRGTNFLKI 479
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
PRK05826 PRK05826
pyruvate kinase; Provisional
 15-467 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 582.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    15 SHRTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGG 94
Cdd:PRK05826   3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    95 EKQLREGEKVSLV--PVEIGDRhpGAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRKGVN 172
Cdd:PRK05826  83 KITLKTGDKFTLDtdQKEEGDK--ERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   173 LPGLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHPDLPVIAKIEKPQAIDNLEEIVAVSNG 252
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   253 IMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVGQ 332
Cdd:PRK05826 241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   333 YPVKSVQMLRKIAEETE------VGLHLVNNPPIENTETHALSeALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSVPV 406
Cdd:PRK05826 321 YPVEAVEAMARICKGAEkefsinLSKHRLDRQFDRIDEAIAMS-AMYAANHLKGVKAIVALTESGRTARLISRFRPGAPI 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2497534   407 IAFTPSEKVYHSLNLVWGIIPFLINEEFDTfEDLIQQAEVLLRDRKMVEKGDQLLIMAGIP 467
Cdd:PRK05826 400 FAVTRDEKTQRRLALYRGVYPVLFDSAADT-DDAAEEALRLLLEKGLVESGDLVVVTSGDP 459
PRK06247 PRK06247
pyruvate kinase; Provisional
 11-483 0e+00

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 542.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    11 MRPLShRTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQ 90
Cdd:PRK06247   1 MKRNR-RVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    91 LPGGEKQLREGEKVSL-VPVEIGDRHpgAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRK 169
Cdd:PRK06247  80 FADGKVQLANGQTFRLdVDDAPGDHD--RVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   170 GVNLPGLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERghpdLPVIAKIEKPQAIDNLEEIVAV 249
Cdd:PRK06247 158 GVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR----VPVMAKIEKPQAIDRLEAIVEA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   250 SNGIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESA 329
Cdd:PRK06247 234 SDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETA 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   330 VGQYPVKSVQMLRKIAEETEVGLHL-----VNNPPIENTETHALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSV 404
Cdd:PRK06247 314 SGKYPVEAVRTMARIIRQVERDPTYpplihAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPL 393

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2497534   405 PVIAFTPSEKVYHSLNLVWGIIPFLiNEEFDTFEDLIQQAEVLLRDRKMVEKGDQLLIMAGIPTKIPRGTNFLKIHRIS 483
Cdd:PRK06247 394 PILALTPNPETARRLALTWGVHCVV-VDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIG 471
PRK06354 PRK06354
pyruvate kinase; Provisional
 12-483 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 533.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    12 RPLSHRTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQL 91
Cdd:PRK06354   4 RDLMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    92 PGGEKQLREGEKVSLVPVEI-GDRHPGAVgiDYPHLATEAKVGERILLDDGLLEMKV--VSIQDPEVICEVVTGGILKSR 168
Cdd:PRK06354  84 EDGPIELKTGDEFILTSREVlGTQEKFSV--TYDGLADEVPVGSRILLDDGLIELEVeeVDKADGELHCKVLVGGVLSNK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   169 KGVNLPGLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHPDLPVIAKIEKPQAIDNLEEIVA 248
Cdd:PRK06354 162 KGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILE 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   249 VSNGIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGES 328
Cdd:PRK06354 242 LCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNET 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   329 AVGQYPVKSVQMLRKIAEETEVGLH----LVNNPPIENTETHALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSV 404
Cdd:PRK06354 322 AAGDYPVEAVQTMATIAVRIEKDLPyrdiLSKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKT 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   405 PVIAFTPSEKVYHSLNLVWGIIPFLI---NEEFDTFEDLIQQAEvllrDRKMVEKGDQLLIMAGIPTKIPRGTNFLKIHR 481
Cdd:PRK06354 402 PILAVTPNESVARRLQLVWGVTPLLVldaPSTDETFDAAINVAQ----ESGLLKQGDLVVITAGTLVGESGSTDLMKVHV 477


                 ..
gi 2497534   482 IS 483
Cdd:PRK06354 478 VG 479
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 17-482 2.80e-168

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 482.97  E-value: 2.80e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   17 RTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGEK 96
Cdd:cd00288   3 RTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGKD 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   97 -QLREGEKVSLV---PVEIGDrhPGAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDP-EVICEVVTGGILKSRKGV 171
Cdd:cd00288  83 iSLKAGDKFLVTtdpAAKKGT--KEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKGV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  172 NLPGLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHpDLPVIAKIEKPQAIDNLEEIVAVSN 251
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGK-DIKIIAKIENQEGVNNFDEILEASD 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  252 GIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVG 331
Cdd:cd00288 240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  332 QYPVKSVQMLRKIAEETEVGLH-------LVNNPPIENTETHALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSV 404
Cdd:cd00288 320 KYPVEAVKAMARICLEAEKALShrvlfneMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  405 PVIAFTPSEKVYHSLNLVWGIIPFLINEEFDTF----EDLIQQAEVLLRDRKMVEKGDQLLIMAGIPTKIPRgTNFLKIH 480
Cdd:cd00288 400 PIIAVTRNEQTARQLHLYRGVYPVLFEEPKPGWqedtDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGS-TNTMRIL 478


                ..
gi 2497534  481 RI 482
Cdd:cd00288 479 TV 480
PRK09206 PRK09206
pyruvate kinase PykF;
17-482 4.59e-149

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 433.71  E-value: 4.59e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    17 RTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGEK 96
Cdd:PRK09206   3 KTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGGND 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    97 -QLREGEKVSLVPVE--IGDRHPGAVgiDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRKGVNL 173
Cdd:PRK09206  83 vSLKAGQTFTFTTDKsvVGNKERVAV--TYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   174 PGLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHPDLPVIAKIEKPQAIDNLEEIVAVSNGI 253
Cdd:PRK09206 161 PGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNFDEILEASDGI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   254 MVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVGQY 333
Cdd:PRK09206 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   334 PVKSVQMLRKIAEETEVGLH-----LVNNPPIENTEthALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSVPVIA 408
Cdd:PRK09206 321 PLEAVSIMATICERTDRVMNsrlesNNDNRKLRITE--AVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILA 398

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2497534   409 FTPSEKVYHSLNLVWGIIPFLInEEFDTFEDLIQQAEVLLRDRKMVEKGDQLLIMAGipTKIPRG-TNFLKIHRI 482
Cdd:PRK09206 399 LTTNEKTARQLVLSKGVVPQLV-KEIASTDDFYRLGKELALQSGLAQKGDVVVMVSG--ALVPSGtTNTASVHVL 470
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 17-352 2.73e-137

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 399.05  E-value: 2.73e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534     17 RTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGEK 96
Cdd:pfam00224   3 RTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGKK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534     97 --QLREGEK--VSLVPVEIGDRHPGAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPE-VICEVVTGGILKSRKGV 171
Cdd:pfam00224  83 diELKAGDEmiVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRKGV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    172 NLPGLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHpDLPVIAKIEKPQAIDNLEEIVAVSN 251
Cdd:pfam00224 163 NLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGK-NIQIIAKIENQEGVNNFDEILEATD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    252 GIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVG 331
Cdd:pfam00224 242 GIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 321

                         330       340
                  ....*....|....*....|.
gi 2497534    332 QYPVKSVQMLRKIAEETEVGL 352
Cdd:pfam00224 322 NYPVEAVRMMHEICLEAEKAL 342
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 9-482 4.12e-127

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 379.11  E-value: 4.12e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534     9 KFMRPLS------HRTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLR-SVEQEMDTPITLLQDL 81
Cdd:PTZ00066  25 KILEPISdndlrqKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVReAAKARPNANLGILLDT 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    82 QGPKIRIGQLPGG-EKQLREGEKVSLVP--VEIGDRHpgAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICE 158
Cdd:PTZ00066 105 KGPEIRTGFLKNHkPITLKEGQTLKITTdyTFLGDET--CISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITK 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   159 VVTGGILKSRKGVNLPGLVLTLPSMTTKDKQD-LEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHpDLPVIAKIEKP 237
Cdd:PTZ00066 183 VLNNATIGERKNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGR-HIKIIPKIENI 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   238 QAIDNLEEIVAVSNGIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILD 317
Cdd:PTZ00066 262 EGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLD 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   318 GTDAVMLSGESAVGQYPVKSVQMLRKIAEETEV---------GLHLVNNPPIENTETHALSEALVVIDgiLDLKYIVTFT 388
Cdd:PTZ00066 342 GTDCVMLSGETANGKFPVEAVNIMAKICFEAETcidyrvlyhAIHLAVPTPVSVQEAVARSAVETAED--INAKLIIALT 419

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   389 TSGFTSLLASNQRPSVPVIAFTPSEKVYHSLNLVWGIIPFLINEEFDTfEDLIQQAEVLLRDRKMVEKGDQLLIMAGIPT 468
Cdd:PTZ00066 420 ETGNTARLISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNSFQGT-DVVIRNAIALAKERGLVESGDSAIAVHGVKE 498

                        490
                 ....*....|....
gi 2497534   469 KIPRGTNFLKIHRI 482
Cdd:PTZ00066 499 EVAGSSNLMKVVKI 512
PLN02461 PLN02461
Probable pyruvate kinase
 17-459 8.03e-117

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 352.74  E-value: 8.03e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    17 RTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGEK 96
Cdd:PLN02461  22 KTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDGKP 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    97 -QLREGEKVSL-VPVEI-GDRHPGAVgiDYPHLATEAKVGERILLDDGLLEMKVVSIqDPE---VICEVVTGGILKSRKG 170
Cdd:PLN02461 102 vQLKQGQEITItTDYSIkGDENMIAM--SYKKLAVDVKPGSVILCADGTITLTVLSC-DVEagtVRCRCENSAMLGERKN 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   171 VNLPGLVLTLPSMTTKDKQD-LEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHpDLPVIAKIEKPQAIDNLEEIVAV 249
Cdd:PLN02461 179 VNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAK-SILLISKVENQEGLDNFDDILAE 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   250 SNGIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESA 329
Cdd:PLN02461 258 SDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETA 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   330 VGQYPVKSVQMLRKIAEETEVGL-------HLVNNPPIENTETHALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRP 402
Cdd:PLN02461 338 AGAYPELAVKTMARICREAEASLdygalfkEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAKYRP 417

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2497534   403 SVPV------------IAFTPSEKV--YHSLnLVWGIIPFLINEEF-----DTFEDLIQQAEVLLRDRKMVEKGDQ 459
Cdd:PLN02461 418 AVPIlsvvvpeittdsFDWSCSDEApaRHSL-IYRGLIPVLAEGSAkatdsESTEEILEAAIEHAKKKGLCKPGDS 492
PLN02623 PLN02623
pyruvate kinase
 12-465 5.05e-110

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 337.67  E-value: 5.05e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    12 RPLSHR-TKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVE-QEMDTPITLLQDLQGPKIRIG 89
Cdd:PLN02623 105 KPSVRRkTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNaQSKDNVIAIMLDTKGPEVRSG 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    90 QLPGGEKqLREGEKVSLVpVEIGDRHPGAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRK 169
Cdd:PLN02623 185 DLPQPIM-LEEGQEFTFT-IKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRR 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   170 GVNLPGLVLTLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGhPDLPVIAKIEKPQAIDNLEEIVAV 249
Cdd:PLN02623 263 HLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCN-ADIHVIVKIESADSIPNLHSIITA 341

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   250 SNGIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESA 329
Cdd:PLN02623 342 SDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETA 421

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   330 VGQYPVKSVQMLRKIAEETEVGLHLVNNPP-IENTETHALSEALVVIDGILDLKY---IVTFTTSGFTSLLASNQRPSVP 405
Cdd:PLN02623 422 HGKFPLKAVKVMHTVALRTEATLPEGTTPPnLGQAFKNHMSEMFAFHATMMANTLgtsIIVFTRTGFMAILLSHYRPSGT 501

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2497534   406 VIAFTPSEKVYHSLNLVWGIIPflINEEF-DTFEDLIQQAEVLLRDRKMVEKGDQL-LIMAG 465
Cdd:PLN02623 502 IFAFTNEKRIQQRLALYQGVCP--IYMQFsDDAEETFARALSLLLNKGMVKEGEEVaLVQSG 561
PRK06739 PRK06739
pyruvate kinase; Validated
 21-359 1.20e-104

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 316.12  E-value: 1.20e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    21 VATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSveqeMDTPITLLQDLQGPKIRIGQLPGGEKQLRE 100
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKS----LDDSIKILGDVQGPKIRLGEIKGEQITLQA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   101 GEKVSLVPVEIGDRHPGAvGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRKGVNLPGLVLTL 180
Cdd:PRK06739  82 GDSFILHTQPVTGSSTEA-SVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   181 PSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHPDLPVIAKIEKPQAIDNLEEIVAVSNGIMVARGDL 260
Cdd:PRK06739 161 PAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIARGDL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   261 GVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVGQYPVKSVQM 340
Cdd:PRK06739 241 GVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVST 320

                        330
                 ....*....|....*....
gi 2497534   341 LRKIAEETEvglHLVNNPP 359
Cdd:PRK06739 321 LRLVSEFAE---HVKKDGP 336
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 17-466 1.54e-101

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 313.61  E-value: 1.54e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    17 RTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGEK 96
Cdd:PLN02762  26 RTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLGGASS 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    97 QLREGEKVSLVPVEI--GDRHPGAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRKGVNL- 173
Cdd:PLN02762 106 AKAEDGEEWTFTVRKfdGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLLPRANLTFw 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   174 --PGLVL----TLPSMTTKDKQDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERG-HPDLPVIAKIEKPQAIDNLEEI 246
Cdd:PLN02762 186 rdGSLVRernaMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSrDSDIGVIAKIESLDSLKNLEEI 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   247 VAVSNGIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSG 326
Cdd:PLN02762 266 IRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALMLSG 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   327 ESAVGQYPVKSVQMLRKIAEETEVGLH------LVNNPPIENTETHALSEAL----VVIDGILDLKYIVTFTTSGFTSLL 396
Cdd:PLN02762 346 ESAMGLYPEKALSVLRSVSLRMELWSReekrheALELPQLSSSLSDRISEEIcnsaAKMANNLGVDAIFVYTKHGHMASL 425

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   397 ASNQRPSVPVIAFTPSEKVYHSLNLVWGIIPFLINEEfDTFEDLIQQAEVLLRDRKMVEKGDQLLIMAGI 466
Cdd:PLN02762 426 LSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFS-DDMESNLNKTFSLLKARGMIKSGDLVIAVSDL 494
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 42-463 5.40e-97

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 300.04  E-value: 5.40e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    42 MNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGEKQLREGEK--VSLVPV--EIGDRHpg 117
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATcyVTTDPAfaDKGTKD-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   118 AVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVI-CEVVTGGILKSRKGVNLPGLVLTLPSMTTKDKQDLEFGLS 196
Cdd:PTZ00300  79 KFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQTLkCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   197 QGIDWVSLSFVRKGEDIHTLKQFLAERGHpDLPVIAKIEKPQAIDNLEEIVAVSNGIMVARGDLGVEVNPEKVPRLQKEI 276
Cdd:PTZ00300 159 QGVDMIFASFIRSAEQVGEVRKALGAKGG-DIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKIL 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   277 IRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVANAILDGTDAVMLSGESAVGQYPVKSVQMLRKIAEETEVGLH--- 353
Cdd:PTZ00300 238 ISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNeyv 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   354 LVNN----PPIENTETHALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSVPVIAFTPSEKVYHSLNLVWGIIPFL 429
Cdd:PTZ00300 318 FFNSikklQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVF 397

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 2497534   430 INEEF----DTFEDLIQQAEVLLRDRKMVEKGDQLLIM 463
Cdd:PTZ00300 398 FDAERlghdEGKEQRVAMGVGFAKSKGYVQSGDLMVVV 435
PLN02765 PLN02765
pyruvate kinase
 18-409 9.99e-75

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 244.19  E-value: 9.99e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    18 TKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQLPGGEKQ 97
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    98 LREGEKVSLVPVEigDRHPGA--VGIDYPHLATEAKVGERILLDDGLLE--------MKVVSIQDPEVICEVvtggilks 167
Cdd:PLN02765 110 LKAGNTVTLTPDQ--SKEASSevLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDVVCTV-------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   168 RKGVNLPGLVLT---------LPSMTTKDKQDLE-FGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHPDLPVIAKIEKP 237
Cdd:PLN02765 180 KNSATLAGSLFTlhvsqvridLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIFAKIENV 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   238 QAIDNLEEIVAVSNGIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITaTQMLDSMIQNSRPTRAEASDVANAILD 317
Cdd:PLN02765 260 EGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLD 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   318 GTDAVMLSGESAVGQYPVKSVQMLRKIAEETEvglhLVNN---------PPIENTETHALSEALVVIDGILDLK--YIVT 386
Cdd:PLN02765 339 GADAILLGAETLRGLYPVETISTVGRICAEAE----KVFNqdlyfkktvKYVGEPMSHLESIASSAVRAAIKVKasVIIV 414

                        410       420
                 ....*....|....*....|...
gi 2497534   387 FTTSGFTSLLASNQRPSVPVIAF 409
Cdd:PLN02765 415 FTSSGRAARLIAKYRPTMPVLSV 437
PRK08187 PRK08187
pyruvate kinase; Validated
 12-344 1.21e-66

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 222.20  E-value: 1.21e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    12 RPLSHRTKIVATI-GPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQ 90
Cdd:PRK08187 129 RPAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGA 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    91 L--PGGEKQLREGEKVSLV---PVEIGDRHPGAVGIDYPHLATEAKVGERILLDDGLLEMKVVSIQDPEVICEVV----T 161
Cdd:PRK08187 209 VagPLGKTRLYTGDRLALVaqgPPRRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTharpK 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   162 GGILKSRKGVNLPGLVLTLPSMTTKDKQDLEFGLSQGiDWVSLSFVRKGEDIHTLKQFLAERGH---PDLPVIAKIEKPQ 238
Cdd:PRK08187 289 GLKLKPEKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALAARRPddwRKLGLVLKIETPR 367

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   239 AIDNLEEIVA-----VSNGIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEASDVAN 313
Cdd:PRK08187 368 AVANLPELIVqaagrQPFGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAM 447

                        330       340       350
                 ....*....|....*....|....*....|.
gi 2497534   314 AilDGTDAVMLSGesavGQYPVKSVQMLRKI 344
Cdd:PRK08187 448 A--ARAECVMLNK----GPYLVEAVTFLDDL 472
PRK14725 PRK14725
pyruvate kinase; Provisional
 32-346 3.28e-53

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 189.00  E-value: 3.28e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    32 EVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITLLQDLQGPKIRIGQL-PGGE--------------- 95
Cdd:PRK14725 156 DLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGPIaPGPRviklrptrdalgrvl 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    96 -------------------------------KQLREGEKVSL-------------------------------------- 106
Cdd:PRK14725 236 tparlwltasespppspppgpvglpvdpewlARLEPGDELRFtdargkkrkltvtevddegvlaegsqtaylangtllrl 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   107 ----------VP-------VEIGDR----------HPGAVGIDYPHLAT-------EAKVGERILLDDGLLEMKVVSIQD 152
Cdd:PRK14725 316 grhdstrvggLPpveqklrLKVGDRlvltrddapgDPAQGDAPPARISCtlpeafrAARVGERVWFDDGKIGAVVVKVEA 395

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   153 PEVICEVV----TGGILKSRKGVNLPGLVLTLPSMTTKDKQDLEFgLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHPDL 228
Cdd:PRK14725 396 DEVELRITharpGGSKLKAGKGINLPDSHLPLPALTDKDLEDLAF-VAKHADIVALSFVRSPEDVRLLLDALEKLGADDL 474

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534   229 PVIAKIEKPQAIDNLEEIV-----AVSNGIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRP 303
Cdd:PRK14725 475 GVVLKIETRRAFENLPRILleamrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLP 554

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 2497534   304 TRAEASDVANAILdgTDAVMLSGesavGQYPVKSVQMLRKIAE 346
Cdd:PRK14725 555 SRAEITDAAMALR--AECVMLNK----GPHIVEAVRVLDDILR 591
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 366-480 1.27e-33

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 122.59  E-value: 1.27e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534    366 HALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSVPVIAFTPSEKVYHSLNLVWGIIPFLINEEfDTFEDLIQQAE 445
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEA-ETTDEMLRRAV 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2497534    446 VLLRDRKMVEKGDQLLIMAGIPTKIPRGTNFLKIH 480
Cdd:pfam02887  80 KVAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
CitE COG2301
Citrate lyase beta subunit [Carbohydrate transport and metabolism];
189-267 3.05e-03

Citrate lyase beta subunit [Carbohydrate transport and metabolism];


Pssm-ID: 441876  Cd Length: 288  Bit Score: 39.36  E-value: 3.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497534  189 QDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFL--AERGHPDLPVIAKIEKPQAIDNLEEIVAVSNGIMVAR-------GD 259
Cdd:COG2301  79 DDLAALVGAGLDGIVLPKVESAEDVRALAALLteLEAEGGSIPLMALIETARGLLNAAEIAAASPRVEALVfgaedlaAD 158


                ....*...
gi 2497534  260 LGVEVNPE 267
Cdd:COG2301 159 LGARRTRD 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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