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Conserved domains on  [gi|24645883|ref|NP_650053|]
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SCP-containing protein C, isoform A [Drosophila melanogaster]

Protein Classification

CAP domain-containing protein( domain architecture ID 10143468)

CAP (CSP/antigen 5/PR1) domain-containing protein similar to Venom allergen 5, CRISP/Allergen/PR-1 and scoloptoxins

CATH:  3.40.33.10
PubMed:  18824526
SCOP:  4001882

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 57-210 2.95e-37

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


:

Pssm-ID: 349399  Cd Length: 144  Bit Score: 128.34  E-value: 2.95e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645883  57 HKLILNLFNELRNNVAGGKIEGLPKAVRMAKMSWCEELSHLALLNVKTCESLPDKCRSTErfaYAGQNNAVFQYSGaete 136
Cdd:cd05380   1 RQEILDAHNELRSKVAKGKLKGLPPAANMPKLKWDCELAKLAQNWAKTCVFAHSPCRNTG---GVGQNLASVSSSG---- 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24645883 137 YTDAEIIKEQIENWFAERSNASPEILasfPEELPNKAVTKFTIAVAEKNTHVGCAAVRFSRDFYNHFVLTCNFA 210
Cdd:cd05380  74 KDLKELIEDAVNAWFDELKDYGFGSN---PNNNFNSGIGHFTQMVWAKTTKVGCAVARCPKGGGNKTYVVCNYS 144
 
Name Accession Description Interval E-value
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 57-210 2.95e-37

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 128.34  E-value: 2.95e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645883  57 HKLILNLFNELRNNVAGGKIEGLPKAVRMAKMSWCEELSHLALLNVKTCESLPDKCRSTErfaYAGQNNAVFQYSGaete 136
Cdd:cd05380   1 RQEILDAHNELRSKVAKGKLKGLPPAANMPKLKWDCELAKLAQNWAKTCVFAHSPCRNTG---GVGQNLASVSSSG---- 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24645883 137 YTDAEIIKEQIENWFAERSNASPEILasfPEELPNKAVTKFTIAVAEKNTHVGCAAVRFSRDFYNHFVLTCNFA 210
Cdd:cd05380  74 KDLKELIEDAVNAWFDELKDYGFGSN---PNNNFNSGIGHFTQMVWAKTTKVGCAVARCPKGGGNKTYVVCNYS 144
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 58-209 6.08e-10

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 56.24  E-value: 6.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645883     58 KLILNLFNELRNNVAGGKiEGLPKAVRMAKMSWCEELSHLALLNVKTCESLPDKCRST--ERFAYAGQNNAVFQYSGAet 135
Cdd:smart00198   4 QEILDAHNKLRSQVAGGF-LAAPAASNMLKLTWDCELASSAQNWANQCPFGHSTPRPGygENLAWWSSSTALPDTYAS-- 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24645883    136 eytDAEI--IKEQIENWFAERSNASPeilasfpeelpNKAVTKFTIAVAEKNTHVGCAAVRFSRDFYNHFVLTCNF 209
Cdd:smart00198  81 ---AAVQlwYDEFQDYGYSSNTCKDT-----------NGKIGHYTQVVWAKTYKVGCGVANCPDGTKKKTVVVCNY 142
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 61-209 2.14e-08

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 51.43  E-value: 2.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645883    61 LNLFNELRnnvaggkieglpKAVRMAKMSWCEELSHLALLNVKTCeslPDKCRSTERFAYAGQNNAVFQYSGAETEYTDA 140
Cdd:pfam00188   1 LDLHNEYR------------AAAGLPPLSWDNELAAAAQDHAKYC---ADNGSHNHRSPYGGNIYARVVAAGYALGDAGP 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24645883   141 EIIKEQIENWFaersnaspeilasfpEELPNKAVTKFTIAVAEKNTHVGCAAVRFSRDFYNHFVltCNF 209
Cdd:pfam00188  66 DSAEDAVDGWY---------------DSPGTYNCGHRTNLLWPKSTKVGCAVAKCGDGGTYYFV--CNY 117
 
Name Accession Description Interval E-value
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 57-210 2.95e-37

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 128.34  E-value: 2.95e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645883  57 HKLILNLFNELRNNVAGGKIEGLPKAVRMAKMSWCEELSHLALLNVKTCESLPDKCRSTErfaYAGQNNAVFQYSGaete 136
Cdd:cd05380   1 RQEILDAHNELRSKVAKGKLKGLPPAANMPKLKWDCELAKLAQNWAKTCVFAHSPCRNTG---GVGQNLASVSSSG---- 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24645883 137 YTDAEIIKEQIENWFAERSNASPEILasfPEELPNKAVTKFTIAVAEKNTHVGCAAVRFSRDFYNHFVLTCNFA 210
Cdd:cd05380  74 KDLKELIEDAVNAWFDELKDYGFGSN---PNNNFNSGIGHFTQMVWAKTTKVGCAVARCPKGGGNKTYVVCNYS 144
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 58-209 6.08e-10

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 56.24  E-value: 6.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645883     58 KLILNLFNELRNNVAGGKiEGLPKAVRMAKMSWCEELSHLALLNVKTCESLPDKCRST--ERFAYAGQNNAVFQYSGAet 135
Cdd:smart00198   4 QEILDAHNKLRSQVAGGF-LAAPAASNMLKLTWDCELASSAQNWANQCPFGHSTPRPGygENLAWWSSSTALPDTYAS-- 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24645883    136 eytDAEI--IKEQIENWFAERSNASPeilasfpeelpNKAVTKFTIAVAEKNTHVGCAAVRFSRDFYNHFVLTCNF 209
Cdd:smart00198  81 ---AAVQlwYDEFQDYGYSSNTCKDT-----------NGKIGHYTQVVWAKTYKVGCGVANCPDGTKKKTVVVCNY 142
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 61-209 2.14e-08

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 51.43  E-value: 2.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645883    61 LNLFNELRnnvaggkieglpKAVRMAKMSWCEELSHLALLNVKTCeslPDKCRSTERFAYAGQNNAVFQYSGAETEYTDA 140
Cdd:pfam00188   1 LDLHNEYR------------AAAGLPPLSWDNELAAAAQDHAKYC---ADNGSHNHRSPYGGNIYARVVAAGYALGDAGP 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24645883   141 EIIKEQIENWFaersnaspeilasfpEELPNKAVTKFTIAVAEKNTHVGCAAVRFSRDFYNHFVltCNF 209
Cdd:pfam00188  66 DSAEDAVDGWY---------------DSPGTYNCGHRTNLLWPKSTKVGCAVAKCGDGGTYYFV--CNY 117
CAP_PI16_HrTT-1 cd05559
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 58-210 8.04e-05

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein; Human peptidase inhibitor 16 (PI16) is also called cysteine-rich secretory protein 9 (CRISP-9) or PSP94-binding protein. Mouse PI16 is also called cysteine-rich protease inhibitor. PI16 is predominantly expressed by cardiac fibroblasts and is exposed to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor. It suppresses the activation of the chemokine chemerin in the myocardium, which may be a part of the cardiac stress response. At high endothelial shear stress, PI16 is an inflammation-regulated inhibitor of matrix metalloproteinase 2 (MMP2). Also included in this subfamily is the HrTT-1 protein, a tail-tip epidermis marker in ascidians. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349405  Cd Length: 134  Bit Score: 41.63  E-value: 8.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645883  58 KLILNLFNELRNNVaggkiegLPKAVRMAKMSWCEELSHLAllnvktcESLPDKC---RSTERfAYAGQNnaVFQYSGAE 134
Cdd:cd05559   2 KLLVDLHNQYRSQV-------SPSAANMLKMTWDTELEALA-------KAYARKCiweHNPDR-GRVGEN--LFASTGKP 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645883 135 TEYTDAeiikeqIENWFAERS--NASPEILAsfpeelPNKAVTKFTIAVAEKNTHVGCAAVRFS----RDFYNHFVLTCN 208
Cdd:cd05559  65 LDVELA------VEDWHNEKEyyNFETKTCA------PGKMCGHYTQVVWANTEKIGCGSYFCEtlegVEWENATLLVCN 132


                ..
gi 24645883 209 FA 210
Cdd:cd05559 133 YE 134
CAP cd00168
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 60-209 1.01e-04

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.


Pssm-ID: 349397  Cd Length: 128  Bit Score: 41.07  E-value: 1.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645883  60 ILNLFNELRNNVAggkieglPKAVRMAKMSWCEELSHLALLNVKTCESLPDKCRSTERfayAGQNNAVFQYSGAeteytd 139
Cdd:cd00168   4 ILDLHNSYRSSVS-------PPASNMPLMAWDQELADVAIGYAKDCIFSHSSPTSRQL---AGENIAASSYDMD------ 67

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645883 140 aeiIKEQIENWFAERSNASpeilASFPEELPNKAVTKFTIAVAEKNTHVGCAAvrFSRDFYNHFVlTCNF 209
Cdd:cd00168  68 ---GVAALQAWHNEIKNYN----FGTAQPGFNSGTGHYTQMVWEKTTKLGCGV--ADCSDNSKFV-VCNY 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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