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Conserved domains on  [gi|24430137|ref|NP_006005|]
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EKC/KEOPS complex subunit LAGE3 [Homo sapiens]

Protein Classification

CTAG/PCC1 family protein( domain architecture ID 10558562)

CTAG/PCC1 family protein similar to human cancer/testis antigen (CTAG) 1 and 2, and yeast EKC/KEOPS complex subunit PCC1, which is a component of the complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine

CATH:  3.30.310.50
Gene Ontology:  GO:0008033
PubMed:  22912744|16874308

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pcc1 pfam09341
Transcription factor Pcc1; Pcc1 is a transcription factor that functions in regulating genes ...
 62-135 1.24e-23

Transcription factor Pcc1; Pcc1 is a transcription factor that functions in regulating genes involved in cell cycle progression and polarised growth.


:

Pssm-ID: 462764  Cd Length: 75  Bit Score: 87.23  E-value: 1.24e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24430137    62 IFTLSVPFPTPLEAEIAHGSLAPDAEPHQ-RVVGKDLTVSGRILVVRWKAEDCRLLRISVINFLDQLSLVVRTMQ 135
Cdd:pfam09341   1 TLTLEIPFPTEREAEIAYRSLAPDLEPSPdLRVRRELSVDGNTLVVTIEATDLRSLRASVNSFLDLLKLVEETME 75
 
Name Accession Description Interval E-value
Pcc1 pfam09341
Transcription factor Pcc1; Pcc1 is a transcription factor that functions in regulating genes ...
 62-135 1.24e-23

Transcription factor Pcc1; Pcc1 is a transcription factor that functions in regulating genes involved in cell cycle progression and polarised growth.


Pssm-ID: 462764  Cd Length: 75  Bit Score: 87.23  E-value: 1.24e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24430137    62 IFTLSVPFPTPLEAEIAHGSLAPDAEPHQ-RVVGKDLTVSGRILVVRWKAEDCRLLRISVINFLDQLSLVVRTMQ 135
Cdd:pfam09341   1 TLTLEIPFPTEREAEIAYRSLAPDLEPSPdLRVRRELSVDGNTLVVTIEATDLRSLRASVNSFLDLLKLVEETME 75
PRK14887 PRK14887
KEOPS complex Pcc1-like subunit; Provisional
 58-120 2.71e-04

KEOPS complex Pcc1-like subunit; Provisional


Pssm-ID: 237849  Cd Length: 84  Bit Score: 37.60  E-value: 2.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24430137   58 MRPHIFTLSVPFPTPLEAEIAHGSLAPDAE--PHQRVVGkDLTVSGRILVVRWKAEDCRLLRISV 120
Cdd:PRK14887   1 MRMHKFTLEFEFETEERARIIYRSVLPEHGdsQGERSKA-DLSLDGNTIVITIEAEDLSALRASL 64
 
Name Accession Description Interval E-value
Pcc1 pfam09341
Transcription factor Pcc1; Pcc1 is a transcription factor that functions in regulating genes ...
 62-135 1.24e-23

Transcription factor Pcc1; Pcc1 is a transcription factor that functions in regulating genes involved in cell cycle progression and polarised growth.


Pssm-ID: 462764  Cd Length: 75  Bit Score: 87.23  E-value: 1.24e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24430137    62 IFTLSVPFPTPLEAEIAHGSLAPDAEPHQ-RVVGKDLTVSGRILVVRWKAEDCRLLRISVINFLDQLSLVVRTMQ 135
Cdd:pfam09341   1 TLTLEIPFPTEREAEIAYRSLAPDLEPSPdLRVRRELSVDGNTLVVTIEATDLRSLRASVNSFLDLLKLVEETME 75
PRK14887 PRK14887
KEOPS complex Pcc1-like subunit; Provisional
 58-120 2.71e-04

KEOPS complex Pcc1-like subunit; Provisional


Pssm-ID: 237849  Cd Length: 84  Bit Score: 37.60  E-value: 2.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24430137   58 MRPHIFTLSVPFPTPLEAEIAHGSLAPDAE--PHQRVVGkDLTVSGRILVVRWKAEDCRLLRISV 120
Cdd:PRK14887   1 MRMHKFTLEFEFETEERARIIYRSVLPEHGdsQGERSKA-DLSLDGNTIVITIEAEDLSALRASL 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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