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Conserved domains on  [gi|24308295|ref|NP_079472|]
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grpE protein homolog 1, mitochondrial precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 72-213 8.06e-55

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


:

Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 171.15  E-value: 8.06e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  72 KETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEIkddnphLKNLYEGLVMTEVQI 151
Cdd:cd00446   1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE------LKNLLEGVEMTLKQL 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24308295 152 QKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGV 213
Cdd:cd00446  75 LKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 72-213 8.06e-55

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 171.15  E-value: 8.06e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  72 KETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEIkddnphLKNLYEGLVMTEVQI 151
Cdd:cd00446   1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE------LKNLLEGVEMTLKQL 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24308295 152 QKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGV 213
Cdd:cd00446  75 LKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
46-215 1.56e-47

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 153.92  E-value: 1.56e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295    46 QSEQKADPPATEKTLLEEKV-KLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQC 124
Cdd:pfam01025   1 EEKKNEEALTDEIESLEEEIeELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   125 VPKEEIkddnphLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGR 204
Cdd:pfam01025  81 APENED------VKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDR 154

                         170
                  ....*....|.
gi 24308295   205 TLRPALVGVVK 215
Cdd:pfam01025 155 VLRPAMVVVSK 165
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 66-215 1.81e-46

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 150.30  E-value: 1.81e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  66 KLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKAtqcvpkEEIKDDNPHLKNLYEGLV 145
Cdd:COG0576   3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERA------LAAAEEDEDVKSLLEGVE 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295 146 MTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:COG0576  77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 51-215 7.90e-39

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 132.87  E-value: 7.90e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   51 ADPPATEKTLLEekvKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEI 130
Cdd:PRK14141  30 EMEDDPEPDPLE---ALKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRALDAIPAEAR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  131 KDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPAL 210
Cdd:PRK14141 107 AAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVPNPDVPNNTVVQVVQAGYTIGERVLRPAM 186


                 ....*
gi 24308295  211 VGVVK 215
Cdd:PRK14141 187 VGVAK 191
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 72-213 8.06e-55

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 171.15  E-value: 8.06e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  72 KETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEIkddnphLKNLYEGLVMTEVQI 151
Cdd:cd00446   1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE------LKNLLEGVEMTLKQL 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24308295 152 QKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGV 213
Cdd:cd00446  75 LKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
46-215 1.56e-47

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 153.92  E-value: 1.56e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295    46 QSEQKADPPATEKTLLEEKV-KLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQC 124
Cdd:pfam01025   1 EEKKNEEALTDEIESLEEEIeELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   125 VPKEEIkddnphLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGR 204
Cdd:pfam01025  81 APENED------VKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDR 154

                         170
                  ....*....|.
gi 24308295   205 TLRPALVGVVK 215
Cdd:pfam01025 155 VLRPAMVVVSK 165
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 66-215 1.81e-46

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 150.30  E-value: 1.81e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  66 KLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKAtqcvpkEEIKDDNPHLKNLYEGLV 145
Cdd:COG0576   3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERA------LAAAEEDEDVKSLLEGVE 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295 146 MTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:COG0576  77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 51-215 7.90e-39

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 132.87  E-value: 7.90e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   51 ADPPATEKTLLEekvKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEI 130
Cdd:PRK14141  30 EMEDDPEPDPLE---ALKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRALDAIPAEAR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  131 KDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPAL 210
Cdd:PRK14141 107 AAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVPNPDVPNNTVVQVVQAGYTIGERVLRPAM 186


                 ....*
gi 24308295  211 VGVVK 215
Cdd:PRK14141 187 VGVAK 191
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 31-215 3.81e-33

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 117.77  E-value: 3.81e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   31 TKQKNSGQNLEEDMGQSEQKADPPA----TEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQA 106
Cdd:PRK14139   4 TQQNPSEQEAEEAGAAAQAAAAAAAaaedAAPALEAELAEAEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKFAIES 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  107 FCKDLLEVADVLEKAtqcvpkeeIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGk 186
Cdd:PRK14139  84 FAESLLPVKDSLEAA--------LADESGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVPAEQ- 154

                        170       180
                 ....*....|....*....|....*....
gi 24308295  187 EPGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14139 155 EPNTVVAVLQKGYTIADRVLRPALVTVAA 183
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 63-217 7.79e-32

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 115.06  E-value: 7.79e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   63 EKVKLE-EQLKETVEKYKralADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEikdDNPHLKNLY 141
Cdd:PRK14155  23 EALKAEvAALKDQALRYA---AEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRATAASPKDS---ADPAVKNFI 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24308295  142 EGLVMTEVQIQKVFTKHGLLKLNP-VGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKEA 217
Cdd:PRK14155  97 IGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQPSTEVAAGGVLQVMQAGYELMGRLVRPAMVAVAAKG 173
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 31-213 6.61e-30

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 109.32  E-value: 6.61e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   31 TKQKNSGQNLEEDMGQSEQKADPPATEKTLLEEKVK-LEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCK 109
Cdd:PRK14140  12 VEETEVEEAVEDEVEEETVEEESEAELLDEEQAKIAeLEAKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLAS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  110 DLLEVADVLEKATQcvpkeeIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPG 189
Cdd:PRK14140  92 DLLPALDNFERALQ------IEADDEQTKSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVMQDEDEDFESN 165

                        170       180
                 ....*....|....*....|....
gi 24308295  190 TVALVSKVGYKLHGRTLRPALVGV 213
Cdd:PRK14140 166 EVVEELQKGYKLKDRVIRPSMVKV 189
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 41-215 2.57e-29

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 107.56  E-value: 2.57e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   41 EEDMGQSEQKADPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEK 120
Cdd:PRK14151   6 TLDLQAPEAAQAEAAAGDDLTARVQELEEQLAAAKDQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLER 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  121 ATqcvpkEEIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYK 200
Cdd:PRK14151  86 GL-----ELSSADDEAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVLKVFQKGYL 160

                        170
                 ....*....|....*
gi 24308295  201 LHGRTLRPALVGVVK 215
Cdd:PRK14151 161 LNGRLLRPAMVVVSK 175
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 32-215 4.92e-27

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 101.92  E-value: 4.92e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   32 KQKNSGQNLEEDMgQSEQKADPPATEKTLLEE------KV-KLEEQLKETVEKYK----RALADTENLRQRSQKLVEEAK 100
Cdd:PRK14150   5 EQKTPQEQVSEEI-EAEVEQQEEADEAELEDEldeadaRIaELEAQLAEAQAEERdsvlRARAEVENIRRRAEQDVEKAH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  101 LYGIQAFCKDLLEVADVLEKATQCVPKEeikddNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFH 180
Cdd:PRK14150  84 KFALEKFANELLPVIDNLERALQAADKE-----NEALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISM 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 24308295  181 TPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14150 159 QESEDHEPNTVMMVMQKGYTLNGRLLRPAMVMVSK 193
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 32-216 1.23e-26

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 101.34  E-value: 1.23e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   32 KQKNSGQNLEEDMGQSEQKADPPATEK--TLLEEKVKL-EEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFC 108
Cdd:PRK14144  19 EHKVENEILEEETDEESQHQEPALGHPsyTALEEQLTLaEQKAHENWEKSVRALAELENVRRRMEREVANAHKYGVEKLI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  109 KDLLEVADVLEKATQCVpkeeIKDDNPhlkNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEP 188
Cdd:PRK14144  99 SALLPVVDSLEQALQLA----DKNSDP---SMHEGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAPGAPP 171

                        170       180
                 ....*....|....*....|....*...
gi 24308295  189 GTVALVSKVGYKLHGRTLRPALVGVVKE 216
Cdd:PRK14144 172 NSVITVFQKGYKLSDRVIRPARVIVSTK 199
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 62-216 1.18e-23

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 92.73  E-value: 1.18e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   62 EEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPkeeiKDDNPHLKNLY 141
Cdd:PRK14161  26 PEITALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRALAHKP----ANSDVEVTNII 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24308295  142 EGLVMTEVQIQKVFTKHGLLKLNP-VGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKE 216
Cdd:PRK14161 102 AGVQMTKDELDKVFHKHHIEEIKPeIGSMFDYNLHNAISQIEHPDHAPNSIITLMQSGYKIRDRLLRPATVQVVKK 177
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 43-216 3.60e-23

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 91.55  E-value: 3.60e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   43 DMGQSEQKADPPATEKtLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKAT 122
Cdd:PRK14147   7 EFDSEDLAQNPPETDP-LKAEVESLRSEIALVKADALRERADLENQRKRIARDVEQARKFANEKLLGELLPVFDSLDAGL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  123 QCVPKEeikddnPHlkNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLH 202
Cdd:PRK14147  86 TAAGTE------PS--PLRDGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQVFQKGYLLN 157

                        170
                 ....*....|....
gi 24308295  203 GRTLRPALVGVVKE 216
Cdd:PRK14147 158 ERLLRPALVVVAKQ 171
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 38-215 1.25e-21

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 87.44  E-value: 1.25e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   38 QNLEEDMGQSEQKADPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADV 117
Cdd:PRK14159   6 QEFENENAENSEHLQDENLQNIEDVEQNKLQKDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  118 LEKATQCVPKEEIKddnphLKnLYEGLVMTEVQIQKVFTKHGLlKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKV 197
Cdd:PRK14159  86 LEAAVNVECHDEIS-----LK-IKEGVQNTLDLFLKKLEKHGV-ALIKEEKEFDPNLHEAMFHVDSENHQSGEVVQVLQK 158

                        170
                 ....*....|....*...
gi 24308295  198 GYKLHGRTLRPALVGVVK 215
Cdd:PRK14159 159 GYKIADRVIRPTKVSVAK 176
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 30-215 3.56e-21

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 86.82  E-value: 3.56e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   30 ATKQKNSGQNLEEDMGQSEQKADPPATEKtlleekvkLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCK 109
Cdd:PRK14153  16 ARNSGSSAEEAEELKEEPEDSTADSETEK--------CREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  110 DLLEVADVLEKATQCVPKEEikDDNPhlknLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPG 189
Cdd:PRK14153  88 DLLEVTDNFERALESARTAE--DMNS----IVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETSEVPDN 161

                        170       180
                 ....*....|....*....|....*.
gi 24308295  190 TVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14153 162 TIVDVCKPGYALNSKVIRPAMVSVAR 187
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 46-215 1.37e-20

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 85.31  E-value: 1.37e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   46 QSEQKADPPATEKtllEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKA---T 122
Cdd:PRK14149  30 QGEEKQEASEKEG---EIKEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAlksA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  123 QCVPKEEikddnphlkNLYEGLVMTEVQIQKVFTKHGLLKLNPVGaKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLH 202
Cdd:PRK14149 107 AEVDKES---------ALTKGLELTMEKLHEVLARHGIEGIECLE-EFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYK 176

                        170
                 ....*....|...
gi 24308295  203 GRTLRPALVGVVK 215
Cdd:PRK14149 177 GRVLRPAMVSIAK 189
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 46-215 2.90e-20

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 84.42  E-value: 2.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   46 QSEQKADPPATEKTLLEEKVKLE----EQLKETVEKYK----RALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADV 117
Cdd:PRK14148  23 ETAQESASGALEELSVEEQLERAkdtiKELEDSCDQFKdealRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPVIDS 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  118 LEKATqcvpKEEIKDDNPhlKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKV 197
Cdd:PRK14148 103 IEQAL----KHEVKLEEA--IAMKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIPNPEFEDNTIFDVFQK 176

                        170
                 ....*....|....*...
gi 24308295  198 GYKLHGRTLRPALVGVVK 215
Cdd:PRK14148 177 GYMLNGRIVRAAKVVIVK 194
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 62-215 1.08e-18

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 80.49  E-value: 1.08e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   62 EEKVKLEEQLKETVEKYK----RALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEeikddNPHL 137
Cdd:PRK10325  42 EKIANLEAQLAEAQTRERdgilRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKA-----NPDM 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24308295  138 KNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK10325 117 SAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 29-213 2.01e-18

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 79.85  E-value: 2.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   29 TATKQKNSGQNL-------EEDMGQSEQKADP-------PATEKtLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQK 94
Cdd:PRK14154  13 SETKAKNKWEKVmeaeeeqEEGGGDGSQEMEPhreglefPSREK-LEGQLTRMERKVDEYKTQYLRAQAEMDNLRKRIER 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   95 LVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEikddnPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNP-VGAKFDPY 173
Cdd:PRK14154  92 EKADIIKFGSKQLITDLLPVADSLIHGLESPASED-----PQVKSMRDGMSLTLDLLHNTLAKHGVQVINPnPGDPFDPA 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 24308295  174 EHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGV 213
Cdd:PRK14154 167 LHEAMSVQAVPDAKPDTIIQVLQKGYQLNGRVLRAARVIV 206
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 48-213 1.97e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 76.80  E-value: 1.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   48 EQKADPPATEktLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKlvEEAKL--YGIQAFCKDLLEVADVLEKATQcv 125
Cdd:PRK14162  34 DQEKQNPVED--LEKEIADLKAKNKDLEDKYLRSQAEIQNMQNRYAK--ERAQLikYESQSLAKDVLPAMDNLERALA-- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  126 pkeeIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEP-GTVALVSKVGYKLHGR 204
Cdd:PRK14162 108 ----VKADDEAAKQLKKGVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVQTVAAENDDQkDHVVQVLQKGYQYKDR 183


                 ....*....
gi 24308295  205 TLRPALVGV 213
Cdd:PRK14162 184 TLRPAMVVV 192
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 35-215 4.08e-17

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 76.11  E-value: 4.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   35 NSGQNLEEDMGQSEQKADPPaTEKTLLEEKVKL---EEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDL 111
Cdd:PRK14145  23 EQMEGPPEDEQAQQNQPQQQ-TVDEIEELKQKLqqkEVEAQEYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVILEL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  112 LEVADVLEKATqcvpkeEIKDDNPHLKnlyEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTV 191
Cdd:PRK14145 102 LPVMDNFERAL------ASSGDYNSLK---EGIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEVEGKQPNEI 172

                        170       180
                 ....*....|....*....|....
gi 24308295  192 ALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14145 173 IEVFQKGYYLKDKVIRPSLVKVAK 196
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 31-213 6.72e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 76.30  E-value: 6.72e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   31 TKQKNSGQNLEEDMG----QSEQKADPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQA 106
Cdd:PRK14143  39 TNPEGDAAEAESSPDsgsaASETAADNAARLAQLEQELESLKQELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCN 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  107 FCKDLLEVADVLEKATQCVPKEeiKDDNPHLKNLYEGLVMtevQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGK 186
Cdd:PRK14143 119 TLSEILPVVDNFERARQQLKPE--GEEAQALHRSYQGLYK---QLVDVLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEH 193

                        170       180
                 ....*....|....*....|....*..
gi 24308295  187 EPGTVALVSKVGYKLHGRTLRPALVGV 213
Cdd:PRK14143 194 PEDVVLEELQRGYHLGGRVLRHAMVKV 220
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 42-215 2.05e-15

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 71.50  E-value: 2.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   42 EDMGQSEQKADPPATEKTLLEEKVKLEEQLKE-------TVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEV 114
Cdd:PRK14158  20 AKEAEAAQGKPEAAQPVAAADRIKELEEALAAkeaeaaaNWDKYLRERADLENYRKRVQKEKEELLKYGNESLILEILPA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  115 ADVLEKATQcvpkeeiKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLN-PVGAKFDPYEHEALFHTPVEGKEPGTVAL 193
Cdd:PRK14158 100 VDNMERALD-------HADEESMSAIIEGIRMTLSMLLSTLKKFGVTPVEaEKGTPFDPAYHQAMCQVESAEQEPNTVVA 172

                        170       180
                 ....*....|....*....|..
gi 24308295  194 VSKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14158 173 VFQKGYLLNERLLRPAMVSVAT 194
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 36-215 2.74e-11

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 60.52  E-value: 2.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   36 SGQNLEEDMGQSEQKADPPATEKTLLEEKVKLEEQLKETvekYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVA 115
Cdd:PRK14146  38 SQTITEETQEQAVEGAETETSLQKELDNAKKEIESLKDS---WARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  116 DVLEKATQcvpkeeIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVS 195
Cdd:PRK14146 115 DNLERVGA------TQNQSEELKPFVEGVKMILKEFYSVLEKSNVIRFDPKGEPFDPMSMEALSSEEGDQYSEETVIDVY 188

                        170       180
                 ....*....|....*....|....
gi 24308295  196 KVGYKLH----GRTLRPALVGVVK 215
Cdd:PRK14146 189 QAGYYYKenedKFTLRPARVRIGK 212
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 30-213 7.15e-11

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 59.58  E-value: 7.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   30 ATKQKNSGQNLEEDMGQSEQKADPPATEKT------LLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYG 103
Cdd:PRK14157  46 AQADANAGADAAPAAAEGEAKAAAEKTGEAqsdsddTLTPLGQAKKEAAEYLEALQRERAEFINYRNRTQKEQDRFRQHG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  104 IQAFCKDLLEVADVLEKATQcvpKEEIKDDNPHLKNlyeglvmtevQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPV 183
Cdd:PRK14157 126 IIDVLTALLPALDDIDRIRE---HSEMDDSFKAVAA----------KIDKAFEKFGVEKFGEKGEDFDPTKHDAILHKPD 192

                        170       180       190
                 ....*....|....*....|....*....|
gi 24308295  184 EGKEPGTVALVSKVGYKLHGRTLRPALVGV 213
Cdd:PRK14157 193 PDAEKETVDTVVEAGYRIGDRVIRAARVVV 222
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 68-214 5.04e-08

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 51.54  E-value: 5.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   68 EEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKAtqcvpKEEIKDDNPHLKNLYEGLvmt 147
Cdd:PRK14142  46 EDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERA-----RKHGDLESGPLKSVADKL--- 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24308295  148 evqiQKVFTKHGLLKLNPVGAKFDPYEHEALFHT--PVEGKEPgTVALVSKVGYKLHGRTLRPALVGVV 214
Cdd:PRK14142 118 ----DSALTGLGLVAFGAEGEDFDPVLHEAVQHEgdGGQGSKP-VIGTVMRQGYQLGEQVLRHALVGVV 181
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 28-215 9.32e-08

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 50.52  E-value: 9.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   28 CTATKQKNSGQNLEEDMGQSEQkaDPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAF 107
Cdd:PRK14160  36 FEEIEKEEIIEDSEESNEVKIE--ELKDENNKLKEENKKLENELEALKDRLLRTVAEYDNYRKRTAKEKEGIYSDACEDV 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  108 CKDLLEVADVLEKAtqcVPKEEIKDDnphlknLYEGLVMTEVQIQKVFTKHGLLKLnPVGAKFDPYEHEALFHTPVEGKE 187
Cdd:PRK14160 114 LKELLPVLDNLERA---AAVEGSVED------LKKGIEMTVKQFKTSLEKLGVEEI-STEGEFDPNLHNAVMHVEDENYG 183

                        170       180
                 ....*....|....*....|....*...
gi 24308295  188 PGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14160 184 ENEIVEVFQKGYKRGDKVIRYSMVKVAN 211
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 42-215 2.73e-07

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 49.35  E-value: 2.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   42 EDMGQSEQKADPP---ATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVL 118
Cdd:PRK14163  24 EPKAASEEGAAPAgdaAATAGLTAQLDQVRTALGERTADLQRLQAEYQNYRRRVERDRVTVKEIAVANLLSELLPVLDDV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  119 EKATQcvpkeeikddnpHlKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVG 198
Cdd:PRK14163 104 GRARE------------H-GELVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAILQPG 170

                        170
                 ....*....|....*..
gi 24308295  199 YKLHGRTLRPALVGVVK 215
Cdd:PRK14163 171 YRIGERTIRPARVAVAE 187
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 62-213 1.24e-06

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 47.13  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   62 EEKVKLEEQLKETVE---KYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCvpkEEIKDDnphlk 138
Cdd:PRK14156  31 PEKSELELANERADEfenKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAKAILPSLDNLERALAV---EGLTDD----- 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24308295  139 nLYEGLVMTEVQIQKVFTKHGLLKLnpVGAKFDPYEHEALFHTPVEGKEPG-TVALVSKVGYKLHGRTLRPALVGV 213
Cdd:PRK14156 103 -VKKGLEMVQESLIQALKEEGVEEV--AVDSFDHNLHMAVQTLPADDEHPAdSIAQVFQKGYKLHERLLRPAMVVV 175
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 67-211 2.92e-05

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 43.64  E-value: 2.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295   67 LEEQLKETVEKYKRALADTENLRQRS----QKLVEEAKlygiQAFCKDLLEVADVLEKATQcvpkeeikddnpHlKNLYE 142
Cdd:PRK14164  82 VEAQLAERTEDLQRVTAEYANYRRRTererQAIIETAK----AGVATDLLPILDDLDLAEQ------------H-GDLNE 144

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308295  143 G-LVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPvEGKEPgTVALVSKVGYKLHGRTLRPALV 211
Cdd:PRK14164 145 GpLKAFSDKLTNVLAGLKVEKFGEEGDAFDPEIHEAVQDLS-SGDEK-VLGTVLRKGYRMGDRVLRTAMV 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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