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Conserved domains on  [gi|242827307|ref|XP_002488806|]
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MFS multidrug transporter, putative [Talaromyces stipitatus ATCC 10500]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 92-525 7.50e-133

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 390.78  E-value: 7.50e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  92 VGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLlGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTI 171
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEV-ANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 172 ACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVL 251
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 252 TMVGGFCTIVSLLFLretyptvllkrktqrliketgntnlrskrhnglstrqlflqaltrpfkilflsPIVFVSSIYVGI 331
Cdd:cd17323  160 AIISGFCLILIFLFL-----------------------------------------------------PIVLLLGLYVGL 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 332 VYGYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRILKARSKptpeAPSGGMKPEYRLPPLVVG 411
Cdd:cd17323  187 VYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKK----KNGGKPEPEARLPPAFIG 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 412 AFFIPAGLFMYGWSAYYKTHWIVPVIGTAIMGIGNIAVFMCITSYLVDAFTIYAASALAANTVVRSIMGALLPLAGPAMY 491
Cdd:cd17323  263 AFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMF 342

                        410       420       430
                 ....*....|....*....|....*....|....
gi 242827307 492 NSMGLGWGNSLLGFIAVVCIPVPWAMIRYGERMR 525
Cdd:cd17323  343 NNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 92-525 7.50e-133

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 390.78  E-value: 7.50e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  92 VGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLlGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTI 171
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEV-ANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 172 ACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVL 251
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 252 TMVGGFCTIVSLLFLretyptvllkrktqrliketgntnlrskrhnglstrqlflqaltrpfkilflsPIVFVSSIYVGI 331
Cdd:cd17323  160 AIISGFCLILIFLFL-----------------------------------------------------PIVLLLGLYVGL 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 332 VYGYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRILKARSKptpeAPSGGMKPEYRLPPLVVG 411
Cdd:cd17323  187 VYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKK----KNGGKPEPEARLPPAFIG 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 412 AFFIPAGLFMYGWSAYYKTHWIVPVIGTAIMGIGNIAVFMCITSYLVDAFTIYAASALAANTVVRSIMGALLPLAGPAMY 491
Cdd:cd17323  263 AFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMF 342

                        410       420       430
                 ....*....|....*....|....*....|....
gi 242827307 492 NSMGLGWGNSLLGFIAVVCIPVPWAMIRYGERMR 525
Cdd:cd17323  343 NNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
92-482 3.07e-37

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 140.49  E-value: 3.07e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  92 VGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTI 171
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAG-LVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 172 ACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVL 251
Cdd:COG2814   91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 252 TMVGGFCTIVSLLFLRETYPTVllkrktqrliketgntnlrskrhnglstrqlfLQALTRPFKILFLSPIVFVSSIYVGI 331
Cdd:COG2814  171 AVLALLALLLLLRLLPESRPAA--------------------------------RARLRGSLRELLRRPRLLLLLLLAFL 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 332 VYGYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRIlkarskptpeapsggmkpeYRLPPLVVG 411
Cdd:COG2814  219 LGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-------------------GRRRLLLIG 279

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242827307 412 AFFIPAGLFMYGWSayykTHWIVPVIGTAIMGIGNIAVFMCITSYLVDAFTI-YAASALAANTVVRSIMGAL 482
Cdd:COG2814  280 LLLLALGLLLLALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPeARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
95-484 5.76e-30

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 120.22  E-value: 5.76e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307   95 VSALTFITPLASSMFAPGVPL-LMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIAC 173
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIG-LLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  174 AVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTM 253
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  254 VGGFCTIVSLLFLRETYPTVLLKRKTQRLIketgntnlrskrhnglstrqlflqaLTRPFKILFLSPIVFVssIYVGIVY 333
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLS-------------------------LIVAWKALLRDPVLWL--LLALLLF 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  334 GYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRilkarskptpeapsggMKPEYRLPPLVVGAF 413
Cdd:pfam07690 213 GFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR----------------LGRRRRLLLALLLLI 276

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242827307  414 FIPAGLFMYGWSAYYKTHWIVPVigtaIMGIGNIAVFMCITSYLVDAFTI-YAASALAANTVVRSIMGALLP 484
Cdd:pfam07690 277 LAALGLLLLSLTLSSLWLLLALL----LLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
133-269 1.22e-25

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 102.34  E-value: 1.22e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  133 SVYVLGFAIGPLILAPASEL----VGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLI 208
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 242827307  209 VQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMVGGFCTIVSLLFLRET 269
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
101-271 2.25e-19

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 89.97  E-value: 2.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 101 ITPLASSMFAPGVPLLMEEFHTTNTLLgSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMG 180
Cdd:PRK11102   2 LMPLAIDMYLPALPVIAADFGVSAGSV-QMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 181 MLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMVGGFCTI 260
Cdd:PRK11102  81 QLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAA 160

                        170
                 ....*....|.
gi 242827307 261 VSLLFLRETYP 271
Cdd:PRK11102 161 LVFFFIPETLP 171
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 92-525 7.50e-133

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 390.78  E-value: 7.50e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  92 VGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLlGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTI 171
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEV-ANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 172 ACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVL 251
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 252 TMVGGFCTIVSLLFLretyptvllkrktqrliketgntnlrskrhnglstrqlflqaltrpfkilflsPIVFVSSIYVGI 331
Cdd:cd17323  160 AIISGFCLILIFLFL-----------------------------------------------------PIVLLLGLYVGL 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 332 VYGYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRILKARSKptpeAPSGGMKPEYRLPPLVVG 411
Cdd:cd17323  187 VYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKK----KNGGKPEPEARLPPAFIG 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 412 AFFIPAGLFMYGWSAYYKTHWIVPVIGTAIMGIGNIAVFMCITSYLVDAFTIYAASALAANTVVRSIMGALLPLAGPAMY 491
Cdd:cd17323  263 AFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMF 342

                        410       420       430
                 ....*....|....*....|....*....|....
gi 242827307 492 NSMGLGWGNSLLGFIAVVCIPVPWAMIRYGERMR 525
Cdd:cd17323  343 NNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
92-482 3.07e-37

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 140.49  E-value: 3.07e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  92 VGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTI 171
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAG-LVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 172 ACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVL 251
Cdd:COG2814   91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 252 TMVGGFCTIVSLLFLRETYPTVllkrktqrliketgntnlrskrhnglstrqlfLQALTRPFKILFLSPIVFVSSIYVGI 331
Cdd:COG2814  171 AVLALLALLLLLRLLPESRPAA--------------------------------RARLRGSLRELLRRPRLLLLLLLAFL 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 332 VYGYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRIlkarskptpeapsggmkpeYRLPPLVVG 411
Cdd:COG2814  219 LGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-------------------GRRRLLLIG 279

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242827307 412 AFFIPAGLFMYGWSayykTHWIVPVIGTAIMGIGNIAVFMCITSYLVDAFTI-YAASALAANTVVRSIMGAL 482
Cdd:COG2814  280 LLLLALGLLLLALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPeARGRASGLYNSAFFLGGPL 347
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 94-511 6.78e-31

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 123.45  E-value: 6.78e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  94 IVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLgSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIAC 173
Cdd:cd17320    3 LLALLVALGPLAIDMYLPALPAIARDLGASASAV-QLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 174 AVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTM 253
Cdd:cd17320   82 ALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 254 VGGFCTIVSLLFLRETYPtvllkrktqrliketgntnlrskrhngLSTRQLFLQALTRPFKILFLSPIVFVSSIYVGIVY 333
Cdd:cd17320  162 LGLLLLLLVLLFLPETLP---------------------------EEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSF 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 334 GYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRIlkarskptpeapsggmkPEYRLPPLVVGAF 413
Cdd:cd17320  215 AGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRF-----------------GPRRLLRLGLLLL 277

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 414 FIPAGLFMYGWSAYYKTHWIVpVIGTAIMGIGNIAVFMCITSYLVDAFTIYAASALAANTVVRSIMGALL-PLAGPAMYN 492
Cdd:cd17320  278 LAAALVLLLAALLGGLSLWPL-VAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAgALVGLLPNG 356

                        410       420
                 ....*....|....*....|
gi 242827307 493 SMG-LGWGNSLLGFIAVVCI 511
Cdd:cd17320  357 TALpMGLLILVLGLLALLLL 376
MFS_1 pfam07690
Major Facilitator Superfamily;
95-484 5.76e-30

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 120.22  E-value: 5.76e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307   95 VSALTFITPLASSMFAPGVPL-LMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIAC 173
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIG-LLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  174 AVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTM 253
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  254 VGGFCTIVSLLFLRETYPTVLLKRKTQRLIketgntnlrskrhnglstrqlflqaLTRPFKILFLSPIVFVssIYVGIVY 333
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLS-------------------------LIVAWKALLRDPVLWL--LLALLLF 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  334 GYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRilkarskptpeapsggMKPEYRLPPLVVGAF 413
Cdd:pfam07690 213 GFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR----------------LGRRRRLLLALLLLI 276

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242827307  414 FIPAGLFMYGWSAYYKTHWIVPVigtaIMGIGNIAVFMCITSYLVDAFTI-YAASALAANTVVRSIMGALLP 484
Cdd:pfam07690 277 LAALGLLLLSLTLSSLWLLLALL----LLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 92-511 1.13e-27

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 114.18  E-value: 1.13e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  92 VGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTI 171
Cdd:cd17324    1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAG-LLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 172 ACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVL 251
Cdd:cd17324   80 LAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 252 TMVGGFCTIVSLLFLRetyptvllkrktqrliketgntnlRSKRHNGLSTRQLflqaltRPFKILFLSPIVFVSSIYVGI 331
Cdd:cd17324  160 AVLALLAALLLWRLLP------------------------SLPPKKPGSLGLL------SSLLLLLRNPRLRLAYLITFL 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 332 VYGYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRILKARSkptpeapsggmkpeyrlppLVVG 411
Cdd:cd17324  210 LFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRAL-------------------LIAL 270

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 412 AFFIPAGLFMYGWSAyyktHWIVPVIGTAIMGIGNIAVFMCITSYLVDAFTIYAASALAANTVVRSIMGALLPLAGPAMY 491
Cdd:cd17324  271 LLLAAALLLLTLLGP----SPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVL 346

                        410       420
                 ....*....|....*....|...
gi 242827307 492 NSMGL---GWGNSLLGFIAVVCI 511
Cdd:cd17324  347 DHGGWagvGWVGAALLLLALLLA 369
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 95-518 1.41e-27

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 114.21  E-value: 1.41e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  95 VSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACA 174
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIG-LIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 175 VSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMV 254
Cdd:cd17325   80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 255 GGFCTIVSLLFLRETYPTvllkrktqrliketgntnlRSKRHNGLSTRQLFLQALTRPFKILFLSPIVFVSSIYVGIVyg 334
Cdd:cd17325  160 ALLALVLALLLLPEPRPP-------------------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGAL-- 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 335 yqylmFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRILkarskptpeapsggmkpeyRLPPLVVGAFF 414
Cdd:cd17325  219 -----EPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG-------------------RKPLILIGLLL 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 415 IPAGLFMYGWSAYYkthWIVpVIGTAIMGIGNIAVFMCITSYLVDAFTIYA-ASALAANTVVRSIMGALLPLAGPAMYNS 493
Cdd:cd17325  275 SAVALLLLPLATSF---WLL-LLLLALLGLGLGLVFPATLALLADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDA 350

                        410       420
                 ....*....|....*....|....*
gi 242827307 494 MGLGWGNSLLGFIAVVCIPVPWAMI 518
Cdd:cd17325  351 FGFATPFLAAAALLLLAAVLFLLLR 375
2_A_01_02 TIGR00880
Multidrug resistance protein;
133-269 1.22e-25

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 102.34  E-value: 1.22e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  133 SVYVLGFAIGPLILAPASEL----VGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLI 208
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 242827307  209 VQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMVGGFCTIVSLLFLRET 269
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 99-482 1.38e-23

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 102.65  E-value: 1.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  99 TFITPLASSMFAPGVPLLMEEFHTTnTLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTD 178
Cdd:cd17503    5 AFMAILDTTIVNVALPTIMGDLGAS-LDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 179 MGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMVGGFC 258
Cdd:cd17503   84 LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 259 -TIVSLLFLRetyptvLLKRKTQRLIketgntnlrskrhnglstrqLFLQALTRpfkiLFLSPIVFVSSIYVGIVYGYqy 337
Cdd:cd17503  164 lLLAPLLDLR------LFKDRNFTLG--------------------LLLSFLLG----LGLFGAMFLLPLYLQNVLGY-- 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 338 lmfSTFTevfeeqyrwptksSGLSFLGIGIGSLLGLFVIGAASDRIlkarskptpeapsgGMKpeyrlPPLVVGAFFIPA 417
Cdd:cd17503  212 ---SAFE-------------SGLVLAPGGLASAILSPLVGRLLDKF--------------GPR-----LLLLAGLLLLAL 256

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242827307 418 GLFMYGWSAYYKTHWIVpVIGTAIMGIGNIAVFMCI-TSYLVDAFTIYAASALAANTVVRSIMGAL 482
Cdd:cd17503  257 GTLLLAFLTPDTSLWLI-ILPLFIRGLGMGLVFMPLnTLALNSLPPEQIGDATALFNTIRQLGGSI 321
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 92-275 1.82e-23

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 100.66  E-value: 1.82e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  92 VGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTI 171
Cdd:COG0477   16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLG-WIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 172 ACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVL 251
Cdd:COG0477   95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLIN 174

                        170       180
                 ....*....|....*....|....
gi 242827307 252 TMVGGFCtIVSLLFLRETYPTVLL 275
Cdd:COG0477  175 APLGLLA-LVLRLRLPESRGLLLA 197
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
92-523 4.51e-23

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 100.71  E-value: 4.51e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  92 VGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTI 171
Cdd:COG2271   12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLG-LLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 172 ACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVL 251
Cdd:COG2271   91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 252 TMVGGFCTIVSLLFLretyptvllkrktqrliketgntnlrskrhnglstrqlflqaltrpfkilflspivfvsSIYVGI 331
Cdd:COG2271  171 GLPGLLLALLRFWLL-----------------------------------------------------------ALAYFL 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 332 VYGYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRILKARSkptpeapsggmkpeyrlPPLVVG 411
Cdd:COG2271  192 VYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRK-----------------LVLAIG 254

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 412 AFFIPAGLFMYGWSayykTHWIVPVIGTAIMGIGNIAVFMCITSYLVDAF-TIYAASALAANTVVRSIMGALLPLAGPAM 490
Cdd:COG2271  255 LLLAALALLLLALL----PSPALAIALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYL 330

                        410       420       430
                 ....*....|....*....|....*....|...
gi 242827307 491 YNSMGLGWGNSLLGFIAVVCIPVPWAMIRYGER 523
Cdd:COG2271  331 LDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 99-266 1.68e-21

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 96.09  E-value: 1.68e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  99 TFITPLASSMFAPGVPLLMEEFHTTNTLLgSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTD 178
Cdd:cd17321    5 VFLAALDVTIVNVALPTIARDLGASPSQL-QWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 179 MGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMVGGFC 258
Cdd:cd17321   84 LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA 163


                 ....*...
gi 242827307 259 TIVSLLFL 266
Cdd:cd17321  164 LLLARTFS 171
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 95-518 4.47e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 95.19  E-value: 4.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  95 VSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACA 174
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLG-LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 175 VSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAA--KGWRWVFWVLT 252
Cdd:cd06174   80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 253 MVGGFCTIVSLLFLRETyptvllkrktqrliketgntnlrsKRHNGLSTRQLFLQALTRPFKILFLSPIVFVSSIYVGIV 332
Cdd:cd06174  160 ALALLAAILLLLVVPDP------------------------PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLV 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 333 YGYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRILKARskptpeapsggmkpeyrlpPLVVGA 412
Cdd:cd06174  216 NLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRK-------------------PLLLIG 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 413 FFIPAGLFMYGWSAyykTHWIVPVIGTAIMGIGNIAVFMCITSYLVDAF-TIYAASALAANTVVRSIMGALLPLAGPAMY 491
Cdd:cd06174  277 LLLMALGLALLLLA---PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFpPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353

                        410       420
                 ....*....|....*....|....*..
gi 242827307 492 NsMGLGWGNsllGFIAVVCIPVPWAMI 518
Cdd:cd06174  354 A-ATFGLTG---AFLVLAVLLLLAAIL 376
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 93-454 1.55e-20

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 94.37  E-value: 1.55e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307   93 GIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLlGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIA 172
Cdd:TIGR00711   5 IVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQ-VQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  173 CAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLT 252
Cdd:TIGR00711  84 CGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  253 MVGGFCTIVSLLFLRETYPTVLLKRKTQRLIKETGNTNL------RSKRHNGLSTRQLFLQALTRPFKI----------- 315
Cdd:TIGR00711 164 PIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSllyglsEGPERGWFDSNEILILSITGLVAIiafvvweltdd 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  316 -------LFLSPIVFVSSIYVGIVYGYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRIlkars 388
Cdd:TIGR00711 244 nplvdlrLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKI----- 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242827307  389 kptpeapsgGMKpeyrlPPLVVGAFFIPAGLFMYGWSAYYKTHWIVPVIGTAIMGIGNIAVFMCIT 454
Cdd:TIGR00711 319 ---------DPR-----KLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLT 370
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 94-383 3.77e-20

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 92.45  E-value: 3.77e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307   94 IVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLgSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIAC 173
Cdd:TIGR00710   9 LLGCLSILGPLGIDMYLPAFPEIAADLSTPASIV-QMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  174 AVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTM 253
Cdd:TIGR00710  88 ALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  254 VGgfcTIVSLLFLretyptvllkrktqRLIKETGNTNLRSkrHNGLSTRQLFLqaltrPFKILFLSPIVFVSSIYVGIVY 333
Cdd:TIGR00710 168 AG---ILLSALIF--------------FILPETLPYEARI--QISTYFETFLL-----LLKSKMFWGYALIYGASFGGFF 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 242827307  334 GYqylmFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRI 383
Cdd:TIGR00710 224 AF----FSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKW 269
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
101-271 2.25e-19

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 89.97  E-value: 2.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 101 ITPLASSMFAPGVPLLMEEFHTTNTLLgSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMG 180
Cdd:PRK11102   2 LMPLAIDMYLPALPVIAADFGVSAGSV-QMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 181 MLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMVGGFCTI 260
Cdd:PRK11102  81 QLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAA 160

                        170
                 ....*....|.
gi 242827307 261 VSLLFLRETYP 271
Cdd:PRK11102 161 LVFFFIPETLP 171
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 92-511 1.29e-18

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 87.63  E-value: 1.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  92 VGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTI 171
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVG-LLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 172 ACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLtAAKGWRWVFWVL 251
Cdd:cd17474   80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 252 TMVGGFCTIVSLLFLRETyptvllKRKTQRLIKETGNTNLRSKRHNGLstrqlflqaltrpfkilflspIVFVSSIYVGI 331
Cdd:cd17474  159 AALIPVAFLAILFLLPEP------KEKAKSSSATKLRDLKKALRGRGL---------------------LTFLVSAFLYF 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 332 VYGYQYLMFSTFteVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGaasdRILKARSKptpeapsggmkpeyRLPPLVVG 411
Cdd:cd17474  212 FLYFAFLTYLPF--LLELLYGISPIIIGLLFAGWSVLLALGSLFVG----RLLKKRFG--------------ARRILVIG 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 412 AFFIPAGLFMYGWSayykTHWIVPVIGTAIMGIGNIAVFMCITSYLVDAFTIYA-ASALAANTVVRSIMGALLPLAGPAM 490
Cdd:cd17474  272 LLLYALSLLLLGFV----PSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGTASSLYNFVRFLGQAVGPLLFGLL 347

                        410       420
                 ....*....|....*....|.
gi 242827307 491 YNSMGLGWGNSLLGFIAVVCI 511
Cdd:cd17474  348 LEIFGLSAPFLVGAAIALAAA 368
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 100-266 4.14e-16

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 79.53  E-value: 4.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 100 FITPLASSMFAPGVPLLMEEFHTTNTLlgSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDM 179
Cdd:cd17502    6 FLAALDQTIVATALPTIVAEFGGLSLV--SWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 180 GMLIAFRFFQGcFGSAPVTNGGGTI-ADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMVGGFC 258
Cdd:cd17502   84 TMLIVGRAIQG-IGGGGLMSLAFIIiADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLA 162


                 ....*...
gi 242827307 259 TIVSLLFL 266
Cdd:cd17502  163 LALLRTIL 170
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
87-519 1.41e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 72.61  E-value: 1.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  87 IKSTNVGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGF 166
Cdd:COG2223    2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLG-LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 167 TVFTIACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRW 246
Cdd:COG2223   81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 247 VFWVLTMVGGFCTIVSLLFLRETYPTVLLKRKTQRliketgntnlrskrhnglstrqlflqaltRPFKILFLSPIVFVSS 326
Cdd:COG2223  161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASL-----------------------------RDQLEALRDPRFWLLS 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 327 IYVGIVYGYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRILKARSkptpeapsggmkpeYRLP 406
Cdd:COG2223  212 LLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRV--------------LLIV 277

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 407 PLVVGAFFIPAGLFMYGWSAYYkthwIVPVIGTAIMGIGNIAVFMCITsylvdafTIYAASALAANTVVRSIMGALLPLA 486
Cdd:COG2223  278 FALMALGLLLLALALGSLWLFL----VLFLLLGLALGGGNGAVFALVP-------DIFPTKNAGAVYGLVGAAGGLGGFL 346

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 242827307 487 GPAMYNSMGLGWGN-----SLLGFIAVVCIPVPWAMIR 519
Cdd:COG2223  347 GPLLFGALLDATGSytaafLVFAVLALVALVLTLLLYR 384
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 114-383 3.44e-13

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 71.23  E-value: 3.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  114 PLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGCFG 193
Cdd:TIGR00895  41 PAISAEWGLDPVQLG-FLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  194 SAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWvltmVGGFCTIVSLLFLRETYP-- 271
Cdd:TIGR00895 120 GGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY----VGGIAPLLLLLLLMRFLPes 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  272 TVLLKRKTQRLIKETGNTNLRSKRHN---GLSTRQLFLQALTRPFKILF-----LSPIVFVSSIYVGIVygyQYLMFSTF 343
Cdd:TIGR00895 196 IDFLVSKRPETVRRIVNAIAPQMQAEaqsALPEQKSTQGTKRSVFKALFqgktaRITVLLWLLYFMLLV---GVYFLTNW 272

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 242827307  344 TEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRI 383
Cdd:TIGR00895 273 LPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL 312
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 95-267 4.36e-13

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 70.68  E-value: 4.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  95 VSALTFITPLASSMFAPGVPLLMEEFHTTN--TLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIA 172
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGasGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 173 CAVSTDMGMLIAFRFFQGCFGSAPVTnGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLT 252
Cdd:cd17330   81 LGLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159

                        170
                 ....*....|....*
gi 242827307 253 MVGGFCTIVSLLFLR 267
Cdd:cd17330  160 ALALLNLVLVLFFLP 174
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 114-274 1.09e-12

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 69.52  E-value: 1.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 114 PLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGcFG 193
Cdd:cd17319   27 PTIMKDLGLSPTQYG-LIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLG-VA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 194 SAPVTNGGG-TIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMVGGFCTIVSLLFLRETYPT 272
Cdd:cd17319  105 EAGFFPGAIkALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVWGL 184


                 ..
gi 242827307 273 VL 274
Cdd:cd17319  185 AL 186
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 95-459 3.72e-12

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 68.00  E-value: 3.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  95 VSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACA 174
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAG-LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 175 VSTDMGMLIAFRFFQGcFGSAPVTNGGGTI-ADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVlTM 253
Cdd:cd17489   80 LATSVALLLVLRLIHG-IGWGAFTTAAATLvADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV-AA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 254 VGGFCTIVSLLFLRETYPtvllKRKTQRLIKETGNTNLRSKRhnglstrqlflqaltrpfkILFLSPIVFVSSIYVGIVy 333
Cdd:cd17489  158 VLALLALLLVFLVKDPPP----VAAEEAEAGTRAFRRLVEKK-------------------VLPPALILFLASIAYGAI- 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 334 gyqylmfSTFTEVFEEQYRWptKSSGLSFLGIGIGSLLGLFVIGAASDRILKARSkptpeapsggmkpeyrlppLVVGAF 413
Cdd:cd17489  214 -------STFLPLYAAERGI--SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTV-------------------IIPGLL 265

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 242827307 414 FIPAGLFMygwsAYYKTHWIVPVIGTAIMGIGNIAVFMCITSYLVD 459
Cdd:cd17489  266 LLALGLLL----LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVD 307
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 113-269 1.09e-11

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 66.45  E-value: 1.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 113 VPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGCF 192
Cdd:cd17365   22 APALAQDWGLSPAQLG-PVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 242827307 193 GSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWvltmVGGFCTIVSLLFLRET 269
Cdd:cd17365  101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL----LGGVPPLILLPLLRGT 173
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 94-275 5.25e-11

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 64.21  E-value: 5.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  94 IVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLgSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIAC 173
Cdd:cd17476    2 TISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQL-SWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 174 AVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGG-VIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLT 252
Cdd:cd17476   81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLA 160

                        170       180
                 ....*....|....*....|...
gi 242827307 253 MVGGFCTIVSLLFLRETYPTVLL 275
Cdd:cd17476  161 ILAAIVAVAAIFWTSPSFIAVLL 183
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 95-262 6.09e-11

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 64.14  E-value: 6.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  95 VSALTFITPLASSMFAPGVPLLMEEFHTTNTLlGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACA 174
Cdd:cd17504    1 LALAALAVMLVETMLSPALPTIQREFGTSAAA-VSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 175 VSTDMGMLIAFRFFQGCfGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMV 254
Cdd:cd17504   80 FAPNLPVLIAGRALQGI-GGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPV 158


                 ....*...
gi 242827307 255 GGFCTIVS 262
Cdd:cd17504  159 AVLLAALV 166
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 118-399 2.10e-10

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 62.64  E-value: 2.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 118 EEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGcFGSAPV 197
Cdd:cd17328   27 SDFLIDDSLAG-LLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVG-IGEASY 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 198 TNGGGT-IADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLT-AAKGWRWVFWVLTMVGGFCTIVSLLFLREtyptvll 275
Cdd:cd17328  105 SPIAPTiIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLAILLLLFVRE------- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 276 krkTQRLIKETGntnlrskrHNGLSTRQLFLQALtrpfKILFLSPIVFVSSIYVGIV----YGYQYLMFSTFTEVFEEQy 351
Cdd:cd17328  178 ---PPRGAAEGG--------VMAKSTATSFLADL----KALAKNPSFILSTLGFTAVsfvtGALAFWAPTFFLRAFGVG- 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 242827307 352 RWPTKSSGLSFLGI-GIGSLLGLFVIGAASDRILKARSKPTPEAPSGGM 399
Cdd:cd17328  242 DLSSADVGLIFGAItCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGL 290
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 86-266 2.23e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 62.59  E-value: 2.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  86 LIKSTNVGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLG 165
Cdd:cd17325  195 LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 166 FTVFTIACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWR 245
Cdd:cd17325  275 SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA 354

                        170       180
                 ....*....|....*....|.
gi 242827307 246 WVFWVLTMVGGFCTIVSLLFL 266
Cdd:cd17325  355 TPFLAAAALLLLAAVLFLLLR 375
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
100-276 9.27e-10

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 60.70  E-value: 9.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 100 FITPLASSMFAPGVPLLMEEF----HTTNTLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAV 175
Cdd:PRK09874  24 FLTGAAFSLVMPFLPLYVEQLgvtgHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 176 STDMGMLIAFRFFQGCFGSApVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMVG 255
Cdd:PRK09874 104 AQNIWQFLILRALLGLLGGF-VPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVL 182

                        170       180
                 ....*....|....*....|.
gi 242827307 256 GFCTIVSLLFLRETYPTVLLK 276
Cdd:PRK09874 183 FLCFLVTLFCIRENFQPVSKK 203
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 100-470 1.84e-09

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 59.56  E-value: 1.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 100 FITPLASSMFAPGV----PLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAV 175
Cdd:cd17475    2 TLAQAAASLVAQGIpalaPFLQEDLHLSLAQVG-LLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 176 STDMGMLIAFRFFQGcFGSAPVTNGGGT-IADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMV 254
Cdd:cd17475   81 VGSYPVLLVLLFLVG-AGYGSVQPGGGRaIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 255 GGFCTIVSLLFLREtyptvllkRKTQRLIKETGNTNLRSKRhnglstrqlflqaltRPFKILFLSPIVFVSSIYVGIVYG 334
Cdd:cd17475  160 SILAAVLFWLFYRE--------PPAASAATESASTLLRSLK---------------EVLRNRDVWLIAIAGALLVAPQFA 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 335 yqylmFSTFTEVF-EEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRILKARSKP-------TPEAPSGGMK-PEYRL 405
Cdd:cd17475  217 -----LLTFLLLFlHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPvlvitaaIAAAALLVLSlLSPGT 291

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 242827307 406 PPLVVGAFFIPAGLFMYGWSAYYKThWIVPV-----IGTAI---MGIGNIAVFMC--ITSYLVDAFTIYAASALA 470
Cdd:cd17475  292 PLWLLVLLLILLGLFAIGWNGLYLT-LVAESagpeqAGTALglaNTINFIGIAIGppLFGLLVDATHSYAPAWLA 365
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 131-285 3.84e-09

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 59.18  E-value: 3.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 131 VVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGcFGSAPVTNGGGTIADLIVQ 210
Cdd:cd06179   37 ISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIG-IGAGTQGLGAAVASELVPN 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 242827307 211 EKRGGVIAIYALGPLLGPVIGPVAGGYLTAAK--GWRWVFWVLTMVGGFCTIVSLLFLRETYPTVLLKRKTQRLIKE 285
Cdd:cd06179  116 KYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYINAIFNALALILLFFFYHPPPRPQLHGSSTRQKLKR 192
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 114-250 8.48e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 57.23  E-value: 8.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 114 PLLMEEFHTTNTLLGSF-VVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGcF 192
Cdd:cd17316   23 PVLAAEFSLGLSLLQTGlLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQG-I 101

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242827307 193 GSAPVTNGGGT-IADLIVQEKRGGVIAI----YALGPLLGPVIGPVAGGYLTAAKGWRWVFWV 250
Cdd:cd17316  102 GIGGEYPGASTyVAEFAPSKRRGFALGLlqsgWALGALLAALVASLLIPLLSGDWGWRILFLI 164
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
100-258 1.71e-08

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 56.49  E-value: 1.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 100 FITPLASSMFAPGVPLLMEEFHTTNTLLGSfVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDM 179
Cdd:PRK15402  23 FATYIANDMIQPGMLAVVEDFNAGAEWVPT-SMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 180 GMLIAFRFFQG---CFGSAPvtnGGGTI------ADLIvqekrgGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWV 250
Cdd:PRK15402 102 EQFTLLRFLQGiglCFIGAV---GYAAIqesfeeADAI------KITALMANVALLAPLLGPLVGAALIHVLPWRGMFVL 172


                 ....*...
gi 242827307 251 LTMVGGFC 258
Cdd:PRK15402 173 FAALAALS 180
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 92-272 1.90e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 56.43  E-value: 1.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  92 VGIVSALTFiTPLASSMFAPGVPLLMEEFHTTNTLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTI 171
Cdd:cd17473    2 ITLLLASTL-TVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 172 ACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLtAAKGWRWVFWVL 251
Cdd:cd17473   81 AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVY 159

                        170       180
                 ....*....|....*....|.
gi 242827307 252 tMVGGFCTIVSLLFLRETYPT 272
Cdd:cd17473  160 -LLALPVLILVLLFLPEPARK 179
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 109-423 3.48e-08

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 55.46  E-value: 3.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  109 FAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFF 188
Cdd:TIGR00881  14 FALAMPYLVEEIGLSKTDLG-LLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWAL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  189 QGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGyLTAAKGWRWVfWVLTMVGGFCTIVSLL---F 265
Cdd:TIGR00881  93 NGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVL-FGIAELYSWH-WVFIVPGIIAIIVSLIcflL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  266 LRETYPTVLLKRKTQRLIKETGNTNlrSKRHNGLSTRQLFLQaltrpfKILFLSPIVFVSSIYVgIVYGYQYLMFSTFTE 345
Cdd:TIGR00881 171 LRDSPQSCGLPPAEEMPNEEPDGDA--EKKEEELTKKQIFLQ------YVLLNKVLWYISLGYV-FVYVVRTGILDWSPL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  346 VFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRILKARSKPTPEAPSGGMKPE---YRLPP----LVVGAFFIPAG 418
Cdd:TIGR00881 242 YLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSllvYWLNPaanpLMDLICLFALG 321


                  ....*
gi 242827307  419 LFMYG 423
Cdd:TIGR00881 322 FLVYG 326
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 104-513 5.38e-08

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 55.00  E-value: 5.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 104 LASSMFAPGVPLLMEEFHTTNTLLGSfVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLI 183
Cdd:cd17371   13 FDLLLLGLVLPALIAEFGLDEAEAGL-LGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 184 AFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAI----YALGPLLGPVIGPVAGGYLTAAKGWRWVFWvltmVGGFCT 259
Cdd:cd17371   92 ILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYvqsgWAVGWLLATLLAALLFPLLPPEIAWRVLFL----LGALPA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 260 IVsLLFLRetyptvllkrktqRLIKETgnTNLRSKRHNGLSTRQLFLQALTrpFKILFLSPIVFVSSIYVGIVYGYQYLM 339
Cdd:cd17371  168 LL-VLFIR-------------RFVKEP--PQWQAARAARRHFADRPSLREL--FSPPLLRTTLLASLLATGALGGYYGIT 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 340 fsTFTEVFEEQYRWPT-KSSGLSFLGIGIGSLLGLFVIGAASDRIlkarskptpeapsgGMKPEYRLpplvvgaFFIPAG 418
Cdd:cd17371  230 --TWLPSYLTGERGLSfEGSAGYLVVTILGGFLGYLAGGFLADRI--------------GRRNNFAL-------FALGSA 286

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 419 LFMYgWSAYYKTHWIVPVIGTAIMGIGNIAVFMCITSYLVDAF-TIYAASALAANTVVRSIMGALLPlAGPAMYNSMGlG 497
Cdd:cd17371  287 ISIL-LYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFpTAVRATAQGFCYNVGRIIGALFP-FLVGFLATSG-S 363

                        410
                 ....*....|....*.
gi 242827307 498 WGNSLLGFIAVVCIPV 513
Cdd:cd17371  364 LGTAIAVFAAVYYIAG 379
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 86-265 7.49e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 54.54  E-value: 7.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  86 LIKSTNVGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLG 165
Cdd:cd06173  204 LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 166 FTVFTIACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWR 245
Cdd:cd06173  284 LGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363

                        170       180
                 ....*....|....*....|
gi 242827307 246 WVFWVLTMVGGFCTIVSLLF 265
Cdd:cd06173  364 AVFLLAGALLLLAALLLLLL 383
emrD PRK11652
multidrug transporter EmrD;
104-282 1.28e-07

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 53.76  E-value: 1.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 104 LASSMFAPGVPLLMEEFHTTNTLLGSfVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLI 183
Cdd:PRK11652  22 MAQTIYVPAIADMARDLNVREGAVQA-VMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 184 AFRFFQGcFGsapvTNGGGTIADLIVQEKRGGVIAIYA-----LGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMVGGFC 258
Cdd:PRK11652 101 AASAIQG-LG----TGVGGVMARTLPRDLYEGTQLRHAnsllnMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGV 175

                        170       180
                 ....*....|....*....|....
gi 242827307 259 TIVSLLFLRETYPTVllKRKTQRL 282
Cdd:PRK11652 176 TFSMARWMPETRPAD--ARRTRVL 197
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
100-269 5.43e-07

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 52.14  E-value: 5.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 100 FITPLASSMFAPGVPLLMEEFHTtNTLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHIcnlGFTVFTIACA---VS 176
Cdd:PRK15403  26 FAAYLTTDLIQPGIINVVRDFNA-DVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLIT---GALIFTLACAatlFT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 177 TDMGMLIAFRFFQG---CFGSapvTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTM 253
Cdd:PRK15403 102 TSMTQFLIARFIQGtsiCFIA---TVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAV 178

                        170
                 ....*....|....*.
gi 242827307 254 VGGFCTIVSLLFLRET 269
Cdd:PRK15403 179 MGLIAFVGLLLAMPET 194
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
94-485 1.96e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.24  E-value: 1.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  94 IVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIAC 173
Cdd:COG0738   12 AIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAG-LLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 174 AVSTDMGMLIAFRFFQGCFGSApVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAK---GWRWVFWV 250
Cdd:COG0738   91 ALAPSYPLLLLALFLLGLGLGL-LDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGlslSWHLPYLI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 251 ltmVGGFCTIVSLLFLRETYPTVLLKRKTQRLIKETGNTNLRSKRhnglstrqlflqaltrpfkILFLSPIVFVssiYVG 330
Cdd:COG0738  170 ---LAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPR-------------------LLLGGLAIFL---YVG 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 331 IvygyQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRIlkarskptpeapsggmkPEYRLppLVV 410
Cdd:COG0738  225 A----EGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-----------------GPVRL--LRL 281

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 242827307 411 GAFFIPAGLFMygwsAYYKTHWIVPVIGTAIMGIGNIAVFMCITSYLVDAFTIYAASALAANTVVRSIMGALLPL 485
Cdd:COG0738  282 SALLAAVGLLL----ALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPP 352
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 99-285 2.05e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 49.96  E-value: 2.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  99 TFITPLASSMFAPGVPLLMEEFHTTNT----LLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACA 174
Cdd:cd17391    5 NFFTGIGFSLIAPFLPLYIEQLGVTSGglveLWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 175 VSTDMGMLIAFRFFQGCFgSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMV 254
Cdd:cd17391   85 FVTNVWQLLILRLLQGVF-SGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGL 163

                        170       180       190
                 ....*....|....*....|....*....|.
gi 242827307 255 GGFCTIVSLLFLRETYPTVllKRKTQRLIKE 285
Cdd:cd17391  164 LFLAFLLTLFFVKEDFKPV--EKKKMVSTKE 192
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 99-510 2.31e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 49.92  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  99 TFITPLASSMFAPGVPLLMEEFHTTNTLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYhICNLGFTVFTIACAVSTD 178
Cdd:cd06173    8 QLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLI-LADLLRALLAAVLALLAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 179 MGM-----LIAFRFFQGCFGS--APVTNGggTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVl 251
Cdd:cd06173   87 LGSlslwlLLVLAFLLGIASAffGPARQA--LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAI- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 252 TMVGGFCTIVSLLFLRETYPTVLLKRKTqrliketgntnlrskrhnglstrqLFLQALTRPFKILFLSPIVFVSSIYVGI 331
Cdd:cd06173  164 NALSFLLSALLLLFIRRPPPAAPGESSS------------------------LLLRDLREGLRYLRRSPLLRLLLLALAL 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 332 VYGYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRILKARSkptpeapsggmkpeyrlppLVVG 411
Cdd:cd06173  220 FALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRL-------------------LLIG 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 412 AFFIPAGLFMYGWSayykTHWIVPVIGTAIMGIGNIAVFMCITSYL---VDAFtiYAASALAANTVVRSIMGALLPLAGP 488
Cdd:cd06173  281 ALLLGLALLVLGLS----PSLWLLLAALFLLGLAGGLFNVPLNTLLqlrVPDE--LRGRVFSVYNALNSGAMPLGALLAG 354

                        410       420
                 ....*....|....*....|..
gi 242827307 489 AMYNSMGLGWGNSLLGFIAVVC 510
Cdd:cd06173  355 LLADALGLSAVFLLAGALLLLA 376
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 113-266 2.52e-06

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 49.87  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 113 VPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGCF 192
Cdd:cd17359   24 LPFLQTDFNLTPFLEG-LVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 193 GSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGP--------VIGPVAGGYLTAAKGWRWVFWVltmvggfCTIVSLL 264
Cdd:cd17359  103 VGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQllayivnyLIANAGGADWLGAEGWRWMLGL-------EAIPAIL 175


                 ..
gi 242827307 265 FL 266
Cdd:cd17359  176 FL 177
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
104-255 2.81e-06

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 49.51  E-value: 2.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 104 LASSMFAPGVPLLMEEFHTTNTLLGSfVVSVYVLGFAIGPLILAPASELVGR--AIIyhicnLGFTVFTIAC---AVSTD 178
Cdd:PRK11043  20 LATDMYLPAFKAIQADLQTSASAVSA-SLSLFLAGFALGQLLWGPLSDRYGRkpVLL-----AGLSLFALGSlgmLWVES 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 179 MGMLIAFRFFQGcFG--SAPVtngggtIADLIVQEKRGGVIA--IYA-LGPL--LGPVIGPVAGGYLTAAKGWRWVFWVL 251
Cdd:PRK11043  94 AAQLLVLRFVQA-VGvcSAAV------IWQALVIDRYPAQKAnrVFAtIMPLvaLSPALAPLLGAWLLNHFGWQAIFATL 166


                 ....
gi 242827307 252 TMVG 255
Cdd:PRK11043 167 FAIT 170
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 97-387 3.12e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 49.48  E-value: 3.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  97 ALTFITPLASSMFAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVS 176
Cdd:cd17477    3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIG-LVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 177 TDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIY----ALGPLLGPVIGPVAGGYLtaakgwrwvfWVLT 252
Cdd:cd17477   82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYstvlGLGFALGPLLLALVGTAG----------ALPF 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 253 MVGGFCTIVSLLFlretyptVLLKRKTQRLIKETGNTNLRskrhnglstrqlflqaltrpfKILFLSPIVFVSSIYVGIV 332
Cdd:cd17477  152 LIAAVLLLLALVP-------LLLTRRAAPEIEEAESISLR---------------------RLLRIAPLALLGAFVAGFL 203

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 242827307 333 YGyqylMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRILKAR 387
Cdd:cd17477  204 EG----AFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRR 254
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 79-263 7.57e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.19  E-value: 7.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  79 NPVNFSGLIKSTNVGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGSFVVSVYVLGFAIGPLILAPASE-LVGRAI 157
Cdd:cd06174  192 VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKP 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 158 IYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGY 237
Cdd:cd06174  272 LLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGF 351

                        170       180
                 ....*....|....*....|....*..
gi 242827307 238 LTAAK-GWRWVFWVLTMVGGFCTIVSL 263
Cdd:cd06174  352 LLAATfGLTGAFLVLAVLLLLAAILLL 378
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 127-269 1.86e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 46.80  E-value: 1.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 127 LGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGcFGSAPVTNGGGTIAD 206
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVG-VTSAGIFTVGFVLGM 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 242827307 207 LIVQEKRGGVIAI-----YALGPLLGPVIgpvagGYLTaaKGWRWVFWVLTMVGGFCTIVSLLFLRET 269
Cdd:cd17317  105 EIVGPKYRSFVGIlfglfWALGYMLLALL-----AYLI--RDWRWLQLAISLPGLLFLLLLWWLPRRT 165
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 129-383 3.32e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 46.47  E-value: 3.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 129 SFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGCFGSapvtnggGTIADLI 208
Cdd:cd17327   44 NWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFES-------GVFPGFI 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 209 V-------QEKRGGVIAIYALGPLLGPVIgpvaGGYLTAA----------KGWRWVFWVLTMVGGFCTIVSLLFLRETYP 271
Cdd:cd17327  117 LylgmwykREEQAKRIAFFYAAAGLGSIF----GGLLAYGvfkilgvgglAGWRWLFIIEGLITIIIGLVIFFWLPDNPS 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 272 TV-LLKRKTQRLIKETGNTNLRSKRHNGLSTRQlFLQALTRPFKILFlspivFVSSIYVGIVYGyqylMFSTFTEVFEEQ 350
Cdd:cd17327  193 KAwFLTEEEKELAVERLRANQTGKGDQKFKWKQ-IKEAFKDPRTWLL-----FLFFFCSQITNN----GISNFLPLILKS 262

                        250       260       270
                 ....*....|....*....|....*....|...
gi 242827307 351 YRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRI 383
Cdd:cd17327  263 LGFYSLQTNLLSVPIGALGAVSLLIAALLSDRF 295
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 145-388 4.37e-05

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 45.70  E-value: 4.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 145 ILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGCFGsAPVTNGGGTIADLIVQEKR----GGVIAIY 220
Cdd:cd17388   57 ILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITG-ATGAVAAAYIADVTPPEQRarnfGLLGAAF 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 221 ALGPLLGPVIGPVAGGYltaakGWRWVFWVLTMVGGFCTIVSLLFLRETYPTvllkrktqrlikeTGNTNLRSKRHNGLS 300
Cdd:cd17388  136 GLGFIAGPALGGLLGEI-----SPRAPFLVAAGLNGLNFLLGLFVLPESLPP-------------ERRRAFRWRRANPFG 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 301 TrqlfLQALTRPFKILFLSPIVFvssiyvgIVYGYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGI-GSLLGLFVIGAA 379
Cdd:cd17388  198 S----LRWLTGFPGLLGLLAVFF-------LIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLlHALFQAFVTGPI 266


                 ....*....
gi 242827307 380 SDRILKARS 388
Cdd:cd17388  267 AKRLGEKRA 275
PRK10504 PRK10504
putative transporter; Provisional
 131-266 4.67e-05

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 45.88  E-value: 4.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 131 VVSVYVLGFAIgpliLAPAS----ELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIAD 206
Cdd:PRK10504  50 VIVSYVLTVAV----MLPASgwlaDRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMK 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 207 LIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMVGGFCTIVSLLFL 266
Cdd:PRK10504 126 IVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLM 185
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 94-284 6.99e-05

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 45.26  E-value: 6.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  94 IVSALTFITPLASSMFAPGVPLLMEEFHTTNTLL---GSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFT 170
Cdd:cd17358    6 VANLGSFSFGIAVGWSSPALPSLMSDNSLSLPLTvaqFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 171 IACAVSTDMGMLIAFRFFQG-----CFGSAPVtngggTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTaakgWR 245
Cdd:cd17358   86 LLIAFAKDVWMLYLGRFLAGfgggaASVVVPV-----YIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP----WR 156

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 242827307 246 WVFWvLTMVGGFCTIVSLLFLRETYPTVLLKRKTQRLIK 284
Cdd:cd17358  157 TLAL-IGAIPPVVFLILLFFIPESPRWLAKKGREEEAEK 194
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 121-511 1.27e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 44.56  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 121 HTTNTLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTV---FTIACAVSTDMGMLIAFRFFQG-CFGSAP 196
Cdd:cd17357   44 DSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVsslLMFLSKSAKSPELLIFGRFLVGiACGLST 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 197 VtngggtIADLIVQEK-----RGGVIAIYALGPLLGPVIGPVAG--GYLTAAKGWRWVFWVLTMVGGFCTIVsLLFLRET 269
Cdd:cd17357  124 G------FVPMYLQEIspselRGALGSLTQIGVTLGILLGQVFGlpSVLGTETLWPYLLFFPGIPALLQLAA-LPFFPES 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 270 YPTVLLKRK--------TQRLIKETG------NTNLRSKRHNGLSTRQLFLQALTRPFKILFLSPIVFV------SSIYV 329
Cdd:cd17357  197 PKFLLISKGdeeeaeksLKFLRGIEDdvdqelEEIKKESEQMGDQKQVSLMQLLRDPSLRLPLLLVLVVsasqqfSGINA 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 330 GIVYGYQYLMFSTFTEVFEEQyrwptKSSGLSFLGIgIGSLLGLFVIGAASDRILKARSkptpeapsggmkpeyrLPPLV 409
Cdd:cd17357  277 IFFYSTFIFENAGFSPQLAEW-----ANLGIGIVNV-LSTIVGPFLIEKVGRRPLLLIS----------------LSVCA 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 410 VGAFFIPAGLFM---YGWSAYYKTHWIVPVIGTAIMGIGNIAVFmcITSYLVDAFTIYAASALAanTVVRSIMGALLPLA 486
Cdd:cd17357  335 VALLLMSVFLFLseqNSWMSYGCIVAIFLFIFFFAIGLGPIPWF--IGAELFPQAPRSAAQSLG--SSVNWTSNFIVGMA 410

                        410       420
                 ....*....|....*....|....*
gi 242827307 487 GPAMYNSMGlgwGNSLLGFIAVVCI 511
Cdd:cd17357  411 FPPLQSIGG---GFVFIIFAIPCAL 432
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 161-391 1.45e-04

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 44.15  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 161 ICNLGFTVFTiacAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYAL-----GPLLGPVIGpvAG 235
Cdd:cd17345   80 IINILIGFVP---SATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNIshnvgGGLVGPLAG--LG 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 236 GYLTAAKGWRWVFWVLTMVGGFCTIVSLLFLRETYPTVLLKrKTQRLIKETGNTNLRSKRHNGLSTRQLFlqaltrpFKI 315
Cdd:cd17345  155 LAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLP-PIEEYKGDYPEEADGEEEEQELSAWEIF-------VKY 226

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242827307 316 LFLSPIVFVSSIYVGIVYGYQYLMFSTFTEVFEEQYRWPTKSSGLSFLGIGIGSLLGLFVIGAASDRILKARSKPT 391
Cdd:cd17345  227 VLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPT 302
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 94-279 1.47e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.14  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  94 IVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIAC 173
Cdd:cd17329    3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 174 AVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAkGWRWVFWVLTM 253
Cdd:cd17329   83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAV 161

                        170       180
                 ....*....|....*....|....*.
gi 242827307 254 VGGFCTIVSLLFLRETYPTVLLKRKT 279
Cdd:cd17329  162 LFLLAALVLLFLLPETRPKRRAAEKT 187
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 112-274 1.68e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 44.10  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 112 GVPLLMEEFHTT---NTLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFF 188
Cdd:cd17315   17 NGALLYIAKDLGfglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 189 QGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYL--TAAKGWRWVFWVLTMVGGFcTIVSLLFL 266
Cdd:cd17315   97 LGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALslSPPGWWRLMFALAAVPALL-QLLLMFFL 175


                 ....*...
gi 242827307 267 RETYPTVL 274
Cdd:cd17315  176 PESRALLV 183
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 109-275 2.64e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 43.42  E-value: 2.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 109 FAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASE-------LVGRAIIYHICNLGFtvftiacAVSTDMGM 181
Cdd:cd17312   22 FSVAKPPIVEEIGLSKDDLG-IIGSAFLIAYAVGKFISGFLSDrsnirrfMSAGLLLSALANIFM-------GFSTSLWF 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 182 LIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMVGGFCTIV 261
Cdd:cd17312   94 FAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAII 173

                        170
                 ....*....|....
gi 242827307 262 SLLFLRETYPTVLL 275
Cdd:cd17312  174 LFFFLRDSPPYVWV 187
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 133-268 4.02e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 43.08  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  133 SVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEK 212
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 242827307  213 RGGVIAIYALGPLLGPVIGPvagGYLTAAKGWRWVFWVLTmVGGFCTIVSLLFLRE 268
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLVLLP---LVAYFIPDWRWLQLAVS-LPTFLFFLLSWFVPE 265
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 113-385 5.47e-04

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 42.32  E-value: 5.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  113 VPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGCF 192
Cdd:TIGR00893  17 APMLQEDLGLSAAQYG-YVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYILRVLLGAA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  193 gSAPVTNGGGTI-ADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLTMVGGFCTIVSLLFLRETYP 271
Cdd:TIGR00893  96 -EAPFFPGIILIvASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIWGVLWLKFIPDPPQ 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  272 TVLLKRKTQRLIKETGNTNLRSKRHNGLSTRQLFLQALTRPFKIlflspIVFVSSIYVGIVYGyqylMFSTFTEVFEEQY 351
Cdd:TIGR00893 175 KAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKYQIKELLKDRRVW-----GLALGQFLVNIGLG----FFLTWFPTYLVQE 245

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 242827307  352 R-WPTKSSGLSFLGIGIGSLLGLFVIGAASDRILK 385
Cdd:TIGR00893 246 RgLSILEAGFMASLPGIVGFIGMILGGRLSDLLLR 280
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 137-253 5.80e-04

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 42.34  E-value: 5.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 137 LGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGV 216
Cdd:cd17379   44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTV 123

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 242827307 217 IAIYALGPLLGPVIGPVAGGYLTAakgWRWVFWVLTM 253
Cdd:cd17379  124 GIVYQMFFTLGLLILPGIAYFIPH---WRWLQLAVTL 157
Sugar_tr pfam00083
Sugar (and other) transporter;
125-269 6.09e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 42.26  E-value: 6.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  125 TLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDM---GMLIAFRFFQG-----CFGSAP 196
Cdd:pfam00083  45 SVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKwsvYQLIVGRVLVGigvggASVLAP 124

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242827307  197 VtngggTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAG---GYLTAAKGWRWVFWVLTMVGGFCTIVsLLFLRET 269
Cdd:pfam00083 125 M-----YISEIAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGLQLVPALLLIIG-LLFLPES 194
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
218-460 8.79e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.81  E-value: 8.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 218 AIYALGPLLGPVIGPVAGGYL--TAAKGWRWVFWVLTMVGGFCTIVSLLFLRETYPTvllkrktqrliketgntnlrskR 295
Cdd:COG2211  154 AFAGLGGLLASVLPPPLVAAFggDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVP----------------------E 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 296 HNGLSTRQLFLQALT-RPFKILFLspIVFVSSIYVGIVYGYQYLMFstftevfeeQYRW--PTKSSGLSFLGIGIGSLLG 372
Cdd:COG2211  212 EEKVSLKESLKALLKnRPFLLLLL--AYLLFFLALALVAALLLYYF---------KYVLglSAALVGLLLALYFLAALLG 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 373 LFVIGAASDRILKARSkptpeapsggmkpeyrlppLVVGAFFIPAGLFMYGWSAYykTHWIVPVIGTAIMGIGNIAVFMC 452
Cdd:COG2211  281 APLWPRLAKRFGKKKA-------------------FIIGLLLAALGLLLLFFLGP--GNLWLLLVLAALAGIGLGAILVL 339


                 ....*...
gi 242827307 453 ITSYLVDA 460
Cdd:COG2211  340 PWAMLADV 347
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 125-275 9.89e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 41.49  E-value: 9.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 125 TLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGcFG------SAPVt 198
Cdd:cd17360   34 TGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVG-LGvgiasmTVPL- 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 199 ngggTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAK-GWRWVFwVLTMVGGFCTIVSLLFLRET--YPTVLL 275
Cdd:cd17360  112 ----YIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPgGWRWML-GLAAVPAVLQFIGLLFLPESprWPSTRR 186
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 94-265 1.20e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.44  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  94 IVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIAC 173
Cdd:cd17329  204 LFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 174 AVSTDMGMLIAFRFFQGcFGSAPVTNGGGTI-ADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWVLT 252
Cdd:cd17329  284 AFANTLAVLILAMIVLT-LGEMLVFPAVQTLvAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILA 362

                        170
                 ....*....|...
gi 242827307 253 MVGGFCTIVSLLF 265
Cdd:cd17329  363 ALGLIAAALLLGL 375
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 95-266 1.60e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 40.67  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  95 VSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGsFVVSVY-VLGFAIGPLIlAPASELVGRAIIYHICNLGFTVFTIAC 173
Cdd:cd17390    1 LYLVGFLDLFGVSMILPLLSTHIRSLGASPTVIG-LIGSVYgALQLFSSPLV-GSWSDVVGRRPVLLICLLLTALGYVLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 174 AVSTDMGMLIAFRFFQGCFGSApVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTA-AKGWRWVfwvlt 252
Cdd:cd17390   79 GFSTSLALLFLSRIPLGIFKHT-QSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAEtDGGFYYV----- 152

                        170
                 ....*....|....
gi 242827307 253 mvggfCTIVSLLFL 266
Cdd:cd17390  153 -----ALLCSAIFI 161
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
94-269 1.70e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 41.01  E-value: 1.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  94 IVSALTFITPLASsmFAPGVPLLMEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVG--RAIIyhicnLGFTVFTI 171
Cdd:COG2807   24 VLVALNLRPAITS--VGPLLPEIRADLGLSATQAG-LLTTLPLLAFGLFAPLAPRLARRFGleRTLL-----LALLLLAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 172 ACAV---STDMGMLIAFRFFQGCFGSApvtnGGGTIADLIVQ---EKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWR 245
Cdd:COG2807   96 GLLLrslAPSVALLLAGTALIGAGIAV----GNVLLPGLIKRwfpDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171

                        170       180
                 ....*....|....*....|....
gi 242827307 246 WVFWVLTMVGGFCTIVSLLFLRET 269
Cdd:COG2807  172 GALAVWALLALLALLLWLPLLRRR 195
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
83-267 2.05e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.63  E-value: 2.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  83 FSGLIKSTNVGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHIC 162
Cdd:COG2223  198 QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIV 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 163 NLGFTVFTIACAVSTD------MGMLIAFRFFQGCFGSAPvtnggGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGG 236
Cdd:COG2223  278 FALMALGLLLLALALGslwlflVLFLLLGLALGGGNGAVF-----ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFG 352

                        170       180       190
                 ....*....|....*....|....*....|..
gi 242827307 237 YLTAAKG-WRWVFWVLTMVGGFCTIVSLLFLR 267
Cdd:COG2223  353 ALLDATGsYTAAFLVFAVLALVALVLTLLLYR 384
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
133-272 3.06e-03

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 40.00  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 133 SVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEK 212
Cdd:PRK10473  45 SVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRR 124

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 242827307 213 RGGVIA----IYALGPLLGPVIGpvaggYLTAAK-GWRWVFWVLTMVGGFCTIVSLLFLRETYPT 272
Cdd:PRK10473 125 RAKVLSllngITCIIPVLAPVLG-----HLIMLKfPWQSLFYTMAAMGILVLLLSLFILKETRPA 184
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 110-485 4.12e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.61  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 110 APGVPLLMEEFHTTNTLLGSFVVSVYvLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQ 189
Cdd:cd17333   16 GILGPSLEEAFNLNVADVSVIFSSQN-AGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 190 GCFGSAPVTNGGGTIADLIvqEKRGGVI-----AIYALGPLLGPVIgpvAGGYLTAAKGWRWVFWVltmVGGFCTIVSLL 264
Cdd:cd17333   95 GLGAGILDTGANTFVGALF--EESSATRlnvlhGFFGLGALIGPLI---ATSLLTSELSWSWAYLI---IGLIYLLLAIL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 265 FLRETYPtvllkrktqrliketgntNLRSKRHNGLSTR--QLFLQALTRPFKILFLspiVFVSSIYVGIVYGYQYLMFST 342
Cdd:cd17333  167 ILLTLFP------------------ELPSARNPQQSVGafSASASRLLRNPSIILG---ALALFLYVGAETAFSSWVPSY 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 343 FTEVFEEQYrwptKSSGLSFLGIGIGSLLGLFVIGAASDRILKARSkptpeapsggmkpeyrlppLVVGAFFIPAGLFMY 422
Cdd:cd17333  226 LVEKKHVSD----GLAGYLLSGFWVGITIGRLLGGPISRRIKPHTL-------------------LVLSGSGALLGLLIL 282

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242827307 423 GWSAYYkthwIVPVIGTAIMGIGNIAVFMCITSYLVDAFTIYAASALAANTVVRSIMGALLPL 485
Cdd:cd17333  283 LLAPTL----VVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPF 341
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
82-222 4.70e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.19  E-value: 4.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  82 NFSGLIKSTNVGIVSALTFITPLASSMFAPGVPLLMEEFHTTNTLLGSFVVSVYVLGFAIGPLILAPASELVGRAIIYHI 161
Cdd:COG2814  199 SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLI 278

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 242827307 162 CNLGFTVFTIACAVSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYAL 222
Cdd:COG2814  279 GLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNS 339
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 117-285 6.00e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.12  E-value: 6.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 117 MEEFHTTNTLLGsFVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACAVSTDMGMLIAFRFFQGcfGSAP 196
Cdd:cd17472   24 KSLPGATPTLIG-LALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG--SGAI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 197 VTNGGGTIADLIVQEKR-------GGVIAIYAlgpLLGPVIGPVAGGYLtaakGWRWVFWVLTMVGGFCTIVSLLFLRET 269
Cdd:cd17472  101 SSVVMALLADLTREENRtkamaliGASIGIAF---AISMVLGPLLAAHL----GVSGLFLITAILSLVSLLILLFFVPDP 173

                        170
                 ....*....|....*.
gi 242827307 270 YPTVLLKRKTQRLIKE 285
Cdd:cd17472  174 PKIVQISEKEKKKLKK 189
PRK10489 PRK10489
enterobactin transporter EntS;
81-266 9.25e-03

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 38.42  E-value: 9.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  81 VNFSGLIKSTNVGIVSALTFITPLASSMFAPGVPLLMEEFhTTNTLLGSFVVSVYVLGFAIGPL---ILAPASE-----L 152
Cdd:PRK10489   8 LDLSLLKTHPAFRAVFIARFISIFGLGLLGVAVPVQIQMM-TGSTLQVGLSVTLTGGAMFIGLMvggVLADRYDrkkliL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307 153 VGRAIiyhiCNLGFTVFTIACAVST-DMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIG 231
Cdd:PRK10489  87 LARGT----CGLGFIGLALNAFLPEpSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVIS 162

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 242827307 232 PVAGGYLTAAKGWRWVFWvLTMVGGFCTIVSLLFL 266
Cdd:PRK10489 163 PALGGLLIAAGGVAWNYG-LAAAGTFITLLPLLRL 196
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 98-250 9.26e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 38.40  E-value: 9.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242827307  98 LTFITPLASSMFAPGVPLLMEEFH--TTNTLLGS-FVVSVYVLGFAIGPLILAPASELVGRAIIYHICNLGFTVFTIACA 174
Cdd:cd17391  209 TTFIIQLANQSIEPILTLYIRQLMgdASNLAFISgLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQA 288

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242827307 175 VSTDMGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPVAGGYLTAAKGWRWVFWV 250
Cdd:cd17391  289 FVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVV 364
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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