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Conserved domains on  [gi|242782825|ref|XP_002480077|]
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bicyclomycin resistance protein, putative [Talaromyces stipitatus ATCC 10500]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 100-528 6.31e-132

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 388.47  E-value: 6.31e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 100 VGLISAITFIVPLASSMFAPGVAQVSSDFNeTNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTV 179
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFH-VSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 180 ACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVL 259
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 260 AIASGVITVGHIIFChetsavvilnrkvkrlqketgnmnlrskldrqisntevlkraivrpakltilsPISVLMSVSTAV 339
Cdd:cd17323  160 AIISGFCLILIFLFL-----------------------------------------------------PIVLLLGLYVGL 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 340 VYGNLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYLQQ-KSAKGLQLKPEDRLPLMLLSGPAI 418
Cdd:cd17323  187 VYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRlKKKNGGKPEPEARLPPAFIGAFLF 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 419 AAGMFWYGWSAKAQTHWIVPILGSSLVGAGNMFFFMPMMGYLVDAYTIYAASALAANTVLRSIGGGLLPLAGQSMYKSLG 498
Cdd:cd17323  267 PIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLG 346

                        410       420       430
                 ....*....|....*....|....*....|
gi 242782825 499 YGWGNSLLGFIMIGFTPVVLFIYRYGEYIR 528
Cdd:cd17323  347 VGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 100-528 6.31e-132

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 388.47  E-value: 6.31e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 100 VGLISAITFIVPLASSMFAPGVAQVSSDFNeTNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTV 179
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFH-VSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 180 ACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVL 259
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 260 AIASGVITVGHIIFChetsavvilnrkvkrlqketgnmnlrskldrqisntevlkraivrpakltilsPISVLMSVSTAV 339
Cdd:cd17323  160 AIISGFCLILIFLFL-----------------------------------------------------PIVLLLGLYVGL 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 340 VYGNLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYLQQ-KSAKGLQLKPEDRLPLMLLSGPAI 418
Cdd:cd17323  187 VYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRlKKKNGGKPEPEARLPPAFIGAFLF 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 419 AAGMFWYGWSAKAQTHWIVPILGSSLVGAGNMFFFMPMMGYLVDAYTIYAASALAANTVLRSIGGGLLPLAGQSMYKSLG 498
Cdd:cd17323  267 PIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLG 346

                        410       420       430
                 ....*....|....*....|....*....|
gi 242782825 499 YGWGNSLLGFIMIGFTPVVLFIYRYGEYIR 528
Cdd:cd17323  347 VGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
89-485 1.30e-41

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 152.82  E-value: 1.30e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  89 MNWTLLKKWTNVGLISAITFIVPLASSMFAPGVAQVSSDFNeTNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYA 168
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLG-ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 169 TCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQ 248
Cdd:COG2814   80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 249 SEGWKWIFWVLAIASGVITVGHIIFCHETSAVVilnrkvkrlqketgnmnlrskldrqisntevlKRAIVRPAKLTILSP 328
Cdd:COG2814  160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAA--------------------------------RARLRGSLRELLRRP 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 329 ISVLMSVSTAVVYGNLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpeDRL 408
Cdd:COG2814  208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF--------------GRR 273

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 242782825 409 PLMLLSGPAIAAGMFWYGWSakaqTHWIVPILGSSLVGAGNMFFFMPMMGYLVDAYTI-YAASALAANTVLRSIGGGL 485
Cdd:COG2814  274 RLLLIGLLLLALGLLLLALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPeARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
103-487 2.69e-33

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 129.85  E-value: 2.69e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  103 ISAITFIVPLASSMFAPGVAQVSSDFNETNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACA 182
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  183 VSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIA 262
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  263 SGVITVGHIIFCHETSAVVILNRKvkrlqketgnmnlrskldrqisntevlKRAIVRPAKLTILSPISVLMSVSTAVVYG 342
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAE---------------------------EARLSLIVAWKALLRDPVLWLLLALLLFG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  343 NLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlKPEDRLPLMLLSGPAIAAGM 422
Cdd:pfam07690 214 FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL-----------GRRRRLLLALLLLILAALGL 282

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242782825  423 FWYGWSakaqTHWIVPILGSSLVGAGNMFFFMPMMGYLVDAYTI-YAASALAANTVLRSIGGGLLP 487
Cdd:pfam07690 283 LLLSLT----LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
141-277 1.64e-29

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 113.13  E-value: 1.64e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  141 SIYVIGLAIGPLVQAPMSEV----YGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLF 216
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 242782825  217 PPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITVGHIIFCHET 277
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
111-277 2.54e-22

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 98.83  E-value: 2.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 111 PLASSMFAPGVAQVSSDFNETNPLLQaLVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISML 190
Cdd:PRK11102   4 PLAIDMYLPALPVIAADFGVSAGSVQ-MTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 191 IVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITVGH 270
Cdd:PRK11102  83 IYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALV 162


                 ....*..
gi 242782825 271 IIFCHET 277
Cdd:PRK11102 163 FFFIPET 169
MFS_efflux_LmrB NF000060
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters ...
 147-258 6.65e-06

lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters Lmr(B) expression in Bacillus subtilis and allows Lmr(B) to confer resistance to lincomycin.


Pssm-ID: 411077 [Multi-domain]  Cd Length: 479  Bit Score: 48.87  E-value: 6.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 147 LAIGPLVqaPMSEVYGRWI----VYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRG 222
Cdd:NF000060  63 LVLGILV--PVSGLLLQWFttrqLFTVSLIFSILGTFIAALAPSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRG 140

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 242782825 223 RALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWV 258
Cdd:NF000060 141 AAMGTIGLVIMFAPAIGPTFSGLVLEHLNWHWIFWI 176
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 100-528 6.31e-132

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 388.47  E-value: 6.31e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 100 VGLISAITFIVPLASSMFAPGVAQVSSDFNeTNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTV 179
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFH-VSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 180 ACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVL 259
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 260 AIASGVITVGHIIFChetsavvilnrkvkrlqketgnmnlrskldrqisntevlkraivrpakltilsPISVLMSVSTAV 339
Cdd:cd17323  160 AIISGFCLILIFLFL-----------------------------------------------------PIVLLLGLYVGL 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 340 VYGNLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYLQQ-KSAKGLQLKPEDRLPLMLLSGPAI 418
Cdd:cd17323  187 VYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRlKKKNGGKPEPEARLPPAFIGAFLF 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 419 AAGMFWYGWSAKAQTHWIVPILGSSLVGAGNMFFFMPMMGYLVDAYTIYAASALAANTVLRSIGGGLLPLAGQSMYKSLG 498
Cdd:cd17323  267 PIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLG 346

                        410       420       430
                 ....*....|....*....|....*....|
gi 242782825 499 YGWGNSLLGFIMIGFTPVVLFIYRYGEYIR 528
Cdd:cd17323  347 VGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
89-485 1.30e-41

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 152.82  E-value: 1.30e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  89 MNWTLLKKWTNVGLISAITFIVPLASSMFAPGVAQVSSDFNeTNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYA 168
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLG-ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 169 TCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQ 248
Cdd:COG2814   80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 249 SEGWKWIFWVLAIASGVITVGHIIFCHETSAVVilnrkvkrlqketgnmnlrskldrqisntevlKRAIVRPAKLTILSP 328
Cdd:COG2814  160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAA--------------------------------RARLRGSLRELLRRP 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 329 ISVLMSVSTAVVYGNLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpeDRL 408
Cdd:COG2814  208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF--------------GRR 273

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 242782825 409 PLMLLSGPAIAAGMFWYGWSakaqTHWIVPILGSSLVGAGNMFFFMPMMGYLVDAYTI-YAASALAANTVLRSIGGGL 485
Cdd:COG2814  274 RLLLIGLLLLALGLLLLALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPeARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
103-487 2.69e-33

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 129.85  E-value: 2.69e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  103 ISAITFIVPLASSMFAPGVAQVSSDFNETNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACA 182
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  183 VSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIA 262
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  263 SGVITVGHIIFCHETSAVVILNRKvkrlqketgnmnlrskldrqisntevlKRAIVRPAKLTILSPISVLMSVSTAVVYG 342
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAE---------------------------EARLSLIVAWKALLRDPVLWLLLALLLFG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  343 NLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlKPEDRLPLMLLSGPAIAAGM 422
Cdd:pfam07690 214 FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL-----------GRRRRLLLALLLLILAALGL 282

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242782825  423 FWYGWSakaqTHWIVPILGSSLVGAGNMFFFMPMMGYLVDAYTI-YAASALAANTVLRSIGGGLLP 487
Cdd:pfam07690 283 LLLSLT----LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 102-522 1.81e-31

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 125.38  E-value: 1.81e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 102 LISAITFIVPLASSMFAPGVAQVSSDFNETNPLLQaLVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVAC 181
Cdd:cd17320    3 LLALLVALGPLAIDMYLPALPAIARDLGASASAVQ-LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 182 AVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAI 261
Cdd:cd17320   82 ALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 262 ASGVITVGHIIFCHETsavvilnrkvkrlqketgnmnlrskldRQISNTEVLKRAIVRPAKLTILSPISVLMSVSTAVVY 341
Cdd:cd17320  162 LGLLLLLLVLLFLPET---------------------------LPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSF 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 342 GNLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGllsfSITSDKYLQQKSAKGLqlkpedrlpLMLLSGPAIAAG 421
Cdd:cd17320  215 AGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILG----SLLNGRLVRRFGPRRL---------LRLGLLLLLAAA 281

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 422 MFWYGWSAKAQTHWIVPILGSSLVGAGNMFFFMPMMGYLVDAYTIYAASALAANTVLR-SIGGGLLPLAGQSMykslGYG 500
Cdd:cd17320  282 LVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQfLIGALAGALVGLLP----NGT 357

                        410       420
                 ....*....|....*....|..
gi 242782825 501 WGNSLLGFIMIGFTPVVLFIYR 522
Cdd:cd17320  358 ALPMGLLILVLGLLALLLLILL 379
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 103-521 1.16e-29

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 119.99  E-value: 1.16e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 103 ISAITFIVPLASSMFAPGVAQVSSDFNETnPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACA 182
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGAS-VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 183 VSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIA 262
Cdd:cd17325   80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 263 SGVITVGHIIFCHETSAVVILNRKVKRLQKETgnmnlrskldrqisntevlKRAIVRPAKLTILSPISVLMSVSTAVVYG 342
Cdd:cd17325  160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSG-------------------LRLLLRDRRLLALFLAIFVLAFAFGALEP 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 343 NLYLMLTTItavfevsYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpeDRLPLMLLSGPAIAAGM 422
Cdd:cd17325  221 FLPLYAAEL-------GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI--------------GRKPLILIGLLLSAVAL 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 423 FWYGWsakAQTHWIVpILGSSLVGAGNMFFFMPMMGYLVDAYTIYA-ASALAANTVLRSIGGGLLPLAGQSMYKSLGYGW 501
Cdd:cd17325  280 LLLPL---ATSFWLL-LLLLALLGLGLGLVFPATLALLADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT 355

                        410       420
                 ....*....|....*....|
gi 242782825 502 GNSLLGFIMIGFTPVVLFIY 521
Cdd:cd17325  356 PFLAAAALLLLAAVLFLLLR 375
2_A_01_02 TIGR00880
Multidrug resistance protein;
141-277 1.64e-29

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 113.13  E-value: 1.64e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  141 SIYVIGLAIGPLVQAPMSEV----YGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLF 216
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 242782825  217 PPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITVGHIIFCHET 277
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 95-283 1.54e-27

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 112.21  E-value: 1.54e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  95 KKWTNVGLISAITFIVPLASSMFAPGVAQVSSDFNETNPLLQaLVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILY 174
Cdd:COG0477   11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLG-WIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 175 VVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKW 254
Cdd:COG0477   90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169

                        170       180
                 ....*....|....*....|....*....
gi 242782825 255 IFWVLAIAsGVITVGHIIFCHETSAVVIL 283
Cdd:COG0477  170 IFLINAPL-GLLALVLRLRLPESRGLLLA 197
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
96-522 5.56e-27

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 112.27  E-value: 5.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  96 KWTNVGLISAITFIVPLASSMFAPGVAQVSSDFNETNPLLqALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYV 175
Cdd:COG2271    8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQL-GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 176 VFTVACAVSSNISMLIVFRFFAGcFGSAPVTIGGGT-IADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKW 254
Cdd:COG2271   87 LATLLFGFATSFWQLLLLRFLLG-LGEAGFFPAALKlIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 255 IFWVLAIASGVITVGHIIfchetsavvilnrkvkrlqketgnmnlrskldrqisntevlkraivrpakltilspisvLMS 334
Cdd:COG2271  166 AFLILGLPGLLLALLRFW-----------------------------------------------------------LLA 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 335 VSTAVVYGNLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYLqqksakglqlkpEDRLPLMLLS 414
Cdd:COG2271  187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLG------------RRRKLVLAIG 254

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 415 GPAIAAGMFWYGWsakAQTHWIVpILGSSLVGAGNMFFFMPMMGYLVDAY-TIYAASALAANTVLRSIGGGLLPLAGQSM 493
Cdd:COG2271  255 LLLAALALLLLAL---LPSPALA-IALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYL 330

                        410       420
                 ....*....|....*....|....*....
gi 242782825 494 YKSLGYGWGNSLLGFIMIGFTPVVLFIYR 522
Cdd:COG2271  331 LDATGYQAAFLLLAALALLAALLALLLLR 359
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 100-512 5.68e-27

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 112.26  E-value: 5.68e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 100 VGLISAITFIVPLASSMFAPGVAQVSSDFNETNPLLqALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTV 179
Cdd:cd17324    1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQA-GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 180 ACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVL 259
Cdd:cd17324   80 LAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 260 AIASGVitvghiifchetsAVVILNRKVKRLQKETgnmnlRSKLDRQISNTEVLKRAIVRPAKLTILspiSVLMSVSTAV 339
Cdd:cd17324  160 AVLALL-------------AALLLWRLLPSLPPKK-----PGSLGLLSSLLLLLRNPRLRLAYLITF---LLFGGFFALY 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 340 VYGNLYLMlttitavfEVSYGWSTGISGLaYIGMGVGNVIGLLSFSITSDKYLqqksakglqlkpedRLPLMLLSGPAIA 419
Cdd:cd17324  219 TYLAPFLT--------DVPGFSSSAIIGL-LLLFGVAGVVGSPLAGRLADRGG--------------RRALLIALLLLAA 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 420 AGMFWYGWSAkaqtHWIVPILGSSLVGAGNMFFFMPMMGYLVDAYTIYAASALAANTVLRSIGGGLLPLAGQSMYKSLGY 499
Cdd:cd17324  276 ALLLLTLLGP----SPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGW 351

                        410
                 ....*....|...
gi 242782825 500 gWGNSLLGFIMIG 512
Cdd:cd17324  352 -AGVGWVGAALLL 363
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 107-485 8.77e-26

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 108.80  E-value: 8.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 107 TFIVPLASSMFAPGVAQVSSDFNeTNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSN 186
Cdd:cd17321    5 VFLAALDVTIVNVALPTIARDLG-ASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 187 ISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIAsgvi 266
Cdd:cd17321   84 LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI---- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 267 tvghiifchetsAVVILnrkvkrlqketgnmnlrskldrqisntevlkraivrpakltILSPISVLMSVSTAVVYGNLYL 346
Cdd:cd17321  160 ------------GLVAL-----------------------------------------LLARTFSGAVLAAFLLGAALGG 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 347 MLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIgllsFSITSDKYLQQKSAKglqlkpedrlPLMLLSGPAIAAGMFWYG 426
Cdd:cd17321  187 LLFLLPLYLQGVLGYSPLQAGLALLPLALAMLV----AAPLAGRLADRFGPR----------LVLVAGLLLTAVGLLLLA 252

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 427 WSAKAQTHWIVpILGSSLVGAGNMFFFMPMMGYLVDAYTI-YAASALAANTVLRSIGGGL 485
Cdd:cd17321  253 LLGADSSVWLL-LPGLVLLGLGLGLFATPLTNAALSSVPKeKAGAASGILNTARQLGGAL 311
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 103-520 3.15e-25

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 107.51  E-value: 3.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 103 ISAITFIVPLASSMFAPGVAQVSSDFNETNPLLqALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACA 182
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQL-GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 183 VSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQ--SEGWKWIFWVLA 260
Cdd:cd06174   80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 261 IASGVITVGHIIFCHETsavvilnrkvkrlqketgnmnlrsKLDRQISNTEVLKRAIVRPAKLTILSPISVLMSVSTAVV 340
Cdd:cd06174  160 ALALLAAILLLLVVPDP------------------------PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLV 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 341 YGNLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYLQqksakglqlkpedRLPLMLLSGPAIAA 420
Cdd:cd06174  216 NLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG-------------RKPLLLIGLLLMAL 282

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 421 GMFWYGWSakaqTHWIVPILGSSLVGAGNMFFFMPMMGYLVDAY-TIYAASALAANTVLRSIGGGLLPLAGQSMYkSLGY 499
Cdd:cd06174  283 GLALLLLA----PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFpPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL-AATF 357

                        410       420
                 ....*....|....*....|.
gi 242782825 500 GWGNSLLGFIMIGFTPVVLFI 520
Cdd:cd06174  358 GLTGAFLVLAVLLLLAAILLL 378
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 107-485 7.75e-25

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 106.12  E-value: 7.75e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 107 TFIVPLASSMFAPGVAQVSSDFNETNPLLQaLVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSN 186
Cdd:cd17503    5 AFMAILDTTIVNVALPTIMGDLGASLDTVQ-WVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 187 ISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWV-LAIASGV 265
Cdd:cd17503   84 LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYInLPIGILA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 266 ITVGHIIfchetsavvilnrkvkrlqketgnmNLRskldrqisnteVLKRAIVRPAkltilspiSVLMSVSTAVVYGNLY 345
Cdd:cd17503  164 LLLAPLL-------------------------DLR-----------LFKDRNFTLG--------LLLSFLLGLGLFGAMF 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 346 LMlttiTAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqkSAKglqlkpedrlpLMLLSGPAI-AAGMFW 424
Cdd:cd17503  200 LL----PLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF----GPR-----------LLLLAGLLLlALGTLL 260

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242782825 425 YGWSAKAQTHWIVpILGSSLVGAGNMFFFMPMMGY-LVDAYTIYAASALAANTVLRSIGGGL 485
Cdd:cd17503  261 LAFLTPDTSLWLI-ILPLFIRGLGMGLVFMPLNTLaLNSLPPEQIGDATALFNTIRQLGGSI 321
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 111-302 5.05e-23

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 100.92  E-value: 5.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  111 PLASSMFAPGVAQVSSDFNETNPLLQaLVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISML 190
Cdd:TIGR00710  18 PLGIDMYLPAFPEIAADLSTPASIVQ-MTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  191 IVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIAsGVITVGH 270
Cdd:TIGR00710  97 LVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLA-GILLSAL 175

                         170       180       190
                  ....*....|....*....|....*....|..
gi 242782825  271 IIFCHETSAVVIlNRKVKRLQKETGNMNLRSK 302
Cdd:TIGR00710 176 IFFILPETLPYE-ARIQISTYFETFLLLLKSK 206
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 100-514 6.11e-23

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 100.34  E-value: 6.11e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 100 VGLISAITFIVPLASSMFAPGVAQVSSDFNETnPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTV 179
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEALGAS-PAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 180 ACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSeGWKWIFWVL 259
Cdd:cd17474   80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 260 AIASGVITVGHIIFCHETSAVVILNRKVKRLQketgnmnlrskldrqisntevlKRAIVRPAKLtilspisVLMSVSTAV 339
Cdd:cd17474  159 AALIPVAFLAILFLLPEPKEKAKSSSATKLRD----------------------LKKALRGRGL-------LTFLVSAFL 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 340 VYGNLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGllsfSITSDKYLQQKSakglqlkpeDRLPLMLLSGPAIA 419
Cdd:cd17474  210 YFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALG----SLFVGRLLKKRF---------GARRILVIGLLLYA 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 420 AGMFWYGWsAKAQTHWIVPILGSSLVGAGNMFFFMPMMGYLVDAYtiYAASALAANTVLRSIGGGLLPLAGQSMYKSLGY 499
Cdd:cd17474  277 LSLLLLGF-VPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEE--ERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGL 353

                        410
                 ....*....|....*...
gi 242782825 500 GW---GNSLLGFIMIGFT 514
Cdd:cd17474  354 SApflVGAAIALAAAVLL 371
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
111-277 2.54e-22

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 98.83  E-value: 2.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 111 PLASSMFAPGVAQVSSDFNETNPLLQaLVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISML 190
Cdd:PRK11102   4 PLAIDMYLPALPVIAADFGVSAGSVQ-MTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 191 IVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITVGH 270
Cdd:PRK11102  83 IYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALV 162


                 ....*..
gi 242782825 271 IIFCHET 277
Cdd:PRK11102 163 FFFIPET 169
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 139-483 1.09e-19

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 92.06  E-value: 1.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  139 VVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPP 218
Cdd:TIGR00711  42 VITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPP 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  219 QQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWV-LAIASGVITVGHIIFCHETSAVVILNRKVKRLQKETGNM 297
Cdd:TIGR00711 122 EKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLInVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLG 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  298 NLRSKLDRQ-----ISNTEVLKRAIVRPA--------KLTILSPI--------------SVLMSVSTAVVYGNLYLmltt 350
Cdd:TIGR00711 202 SLLYGLSEGpergwFDSNEILILSITGLVaiiafvvwELTDDNPLvdlrlfkyrnftigCVYMSLLGLGLYGSFYL---- 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  351 ITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpeDRLPLMLLSGPAIAAGMFWYGWSAK 430
Cdd:TIGR00711 278 LPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKI--------------DPRKLVTIGLILYAVGFYWRAFTFT 343

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 242782825  431 AQTHWIVPILGSSLVGAGNMFFFMPMMGYLVD---AYTIYAASALAanTVLRSIGG 483
Cdd:TIGR00711 344 PDTPFLAIALPQFIRGFGMGCFFMPLTTIALSglpPHKIARGSSLS--NFTRQLGG 397
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 139-402 1.27e-18

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 87.80  E-value: 1.27e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  139 VVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGcfgsapVTIGGGTI------ 212
Cdd:TIGR00895  57 LFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAG------LGLGGLMPnlnalv 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  213 ADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITVGHIIFCHETSAVVILNRKVKRLQK 292
Cdd:TIGR00895 131 SEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRI 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  293 -----ETGNMNLRSKLDRQISNTEVlKRAIVRPAKLTILSPISVLMSVSTAVVYGNLYlMLTTITAVFEVSYGWSTGISG 367
Cdd:TIGR00895 211 vnaiaPQMQAEAQSALPEQKSTQGT-KRSVFKALFQGKTARITVLLWLLYFMLLVGVY-FLTNWLPKLMVELGFSLSLAA 288

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 242782825  368 LAYIGMGVGNVIGLLSFSITSDKYLQQKSAKGLQL 402
Cdd:TIGR00895 289 TGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLL 323
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
95-520 2.97e-17

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 83.78  E-value: 2.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  95 KKWTNVGLISAITFIVPLASSMFAPGVAQVSSDFNETNPLLqALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILY 174
Cdd:COG2223    2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL-GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 175 VVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKW 254
Cdd:COG2223   81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 255 IFWVLAIASGVITVGHIIFCHETSAvvilnrkvkrlqketgnmnlrskldrqisNTEVLKRAIVRPAKLTILSPISVLMS 334
Cdd:COG2223  161 AFLILGILLLVVAVLAWLFLRDPPA-----------------------------GAAAAAKASLRDQLEALRDPRFWLLS 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 335 VSTAVVYGNLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpeDRLPLMLLS 414
Cdd:COG2223  212 LLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI--------------GGRRVLLIV 277

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 415 GPAIAAGMFWYGWsakAQTHWIVPILGSSLVGAGNMFFFMPMMGYLVDaytIYAASALAANTVLRSIGGGLLPLAGQSMY 494
Cdd:COG2223  278 FALMALGLLLLAL---ALGSLWLFLVLFLLLGLALGGGNGAVFALVPD---IFPTKNAGAVYGLVGAAGGLGGFLGPLLF 351

                        410       420
                 ....*....|....*....|....*.
gi 242782825 495 KSLGYGWGNSLLGFIMIGFTPVVLFI 520
Cdd:COG2223  352 GALLDATGSYTAAFLVFAVLALVALV 377
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 101-520 5.67e-16

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 79.57  E-value: 5.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 101 GLISAITFIVPLASSMFAPGVAQVSSDFneTNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVA 180
Cdd:cd17316    5 GLGWFFDAYDFFLIGFVAPVLAAEFSLG--LSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 181 CAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSL----YTLGPVAGPAIGPIAGGFLSQSEGWKWIF 256
Cdd:cd17316   83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLlqsgWALGALLAALVASLLIPLLSGDWGWRILF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 257 WVLAIASGVItvghiifchetsavvilnrkvkrlqketgnmnlrskldrqisntevlkraivrpaklTILSPISVLMSVS 336
Cdd:cd17316  163 LIGALPALLA---------------------------------------------------------LLLRRRTLLLILL 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 337 TAVVYGNLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpeDRLPLMLLSGP 416
Cdd:cd17316  186 WFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI--------------GRKKTLVIGLI 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 417 AIAAGMFWYGWSAKAQTHWIvpILGSSLVGAGNMFFFMPMMGYLVDAY-TIYAASALAANTVLRSIGGGLLPLAGQSMyk 495
Cdd:cd17316  252 LSGILALPLFYLLSGSPTLL--LLLLFILSFFVGGVWGALYAYLAELFpTEVRATGVGLSYNLGRLGGGGAPPLIALL-- 327

                        410       420
                 ....*....|....*....|....*
gi 242782825 496 sLGYGWGNSLLGFIMIGFTPVVLFI 520
Cdd:cd17316  328 -LASTGGTGVPALILALLAIVALIV 351
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 124-275 1.84e-15

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 77.60  E-value: 1.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 124 VSSDFNETNplLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSA 203
Cdd:cd17502   22 IVAEFGGLS--LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 204 PVTIGGGTIADLFPPQQRGRALSLytLGPVAGPA--IGPIAGGFLSQSEGWKWIFWV--------LAIASGVITVGHIIF 273
Cdd:cd17502  100 LMSLAFIIIADLVPPRERGKYQGY--IGAVFGIAsvAGPLIGGAFTDHLSWRWCFYInlpigglaLALLRTILLSSIFGF 177


                 ..
gi 242782825 274 CH 275
Cdd:cd17502  178 LF 179
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 122-268 4.48e-15

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 76.84  E-value: 4.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 122 AQVSSDFNETnPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGcFG 201
Cdd:cd17319   27 PTIMKDLGLS-PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLG-VA 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 242782825 202 SAPVTIGGG-TIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITV 268
Cdd:cd17319  105 EAGFFPGAIkALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAV 172
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 103-275 5.47e-15

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 77.67  E-value: 5.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 103 ISAITFIVPLASSMFAPGVAQVSSDFNETnpllqaLVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACA 182
Cdd:cd06179    7 YFAQLFGVTLPAAVLPFIVADLGPSSNST------WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 183 VSSNISMLIVFRFFAGcFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFL--SQSEGWKWIFWVLA 260
Cdd:cd06179   81 TAKSVNMLIGGQALIG-IGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINA 159

                        170
                 ....*....|....*
gi 242782825 261 IASGVITVGHIIFCH 275
Cdd:cd06179  160 IFNALALILLFFFYH 174
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 103-511 3.07e-14

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 74.15  E-value: 3.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 103 ISAITFIVPLASSMFAPGVAQVSSDFNETN--PLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVA 180
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGasGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 181 CAVSSNISMLIVFRFFAGCFGSAPVTIGGgTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLA 260
Cdd:cd17330   81 LGLSRNLWLLFLARFLDGLTGGNVSVAQA-YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 261 IASGVitvghiifchetSAVVILnrkvkrlqketgnmnlrskldrqisntevlkrAIVRPAKLTILspISVLMSVSTAVV 340
Cdd:cd17330  160 ALALL------------NLVLVL--------------------------------FFLPPLRRLLL--VYFLIALAFAGL 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 341 YGNLYLMLttitavfEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYLQQKsakglqlkpedrlPLMLLSGPAIAA 420
Cdd:cd17330  194 ESVFSLFL-------KDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGER-------------KLLRLGLLLAII 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 421 GMFWYGWSakAQTHWIVpiLGSSLVGAGNMFFFMPMMGYLVDAYTIYA-ASALAANTVLRSIGGGLLPLAGQSMYKSLGY 499
Cdd:cd17330  254 GLLLLPFA--SSVPLLV--LAAAILAFGTGIVFPALSALLSKSVPSKEqGKAQGIIQSLQSLARIIGPLLAGPLYSFLGP 329

                        410
                 ....*....|..
gi 242782825 500 GWGNSLLGFIMI 511
Cdd:cd17330  330 GVPFLLAAGLLL 341
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 121-269 3.53e-14

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 74.14  E-value: 3.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 121 VAQVSSDFNeTNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGcf 200
Cdd:cd17359   24 LPFLQTDFN-LTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGG-- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 201 gsapVTIGGGT------IADLFPPQQRGRALSLYTLGPVAGP--------AIGPIAGGFLSQSEGWKWIFWVLAIASGVI 266
Cdd:cd17359  101 ----LAVGGASalvpmyIAEVAPAEIRGRLVSLNQLMIVFGQllayivnyLIANAGGADWLGAEGWRWMLGLEAIPAILF 176


                 ...
gi 242782825 267 TVG 269
Cdd:cd17359  177 LLG 179
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 137-268 6.98e-14

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 73.00  E-value: 6.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 137 ALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLF 216
Cdd:cd17365   37 GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYA 116

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 242782825 217 PPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITV 268
Cdd:cd17365  117 PARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP 168
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 104-268 5.56e-13

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 70.30  E-value: 5.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 104 SAITFIVPLASSMFAPGVAQVSSDFNeTNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAV 183
Cdd:cd17504    2 ALAALAVMLVETMLSPALPTIQREFG-TSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 184 SSNISMLIVFRFFAGCfGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIAS 263
Cdd:cd17504   81 APNLPVLIAGRALQGI-GGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159


                 ....*
gi 242782825 264 GVITV 268
Cdd:cd17504  160 VLLAA 164
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 136-518 8.74e-13

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 70.02  E-value: 8.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 136 QALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGcFGSAPVTIGGGT-IAD 214
Cdd:cd17371   36 AGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAG-LGFGGEWAAGAAlMAE 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 215 LFPPQQRGRALSL----YTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVlaiasGVITVGHIIFchetsavvilnrkVKRL 290
Cdd:cd17371  115 YVPARHRGKALGYvqsgWAVGWLLATLLAALLFPLLPPEIAWRVLFLL-----GALPALLVLF-------------IRRF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 291 QKETgNMNLRSKLDRQISNTEVLKRAIVRPAKLTILSPISVLMSVSTAVVYGNLYLMLTTITAVFEVSYGWSTGISGLAY 370
Cdd:cd17371  177 VKEP-PQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTI 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 371 IGMgvgnVIGLLSFSITSDKYlqqksakglqlkpeDRLPLMLLSGPAIAAGMFWY--GWSAKAQTHWIVPILGSSLVGA- 447
Cdd:cd17371  256 LGG----FLGYLAGGFLADRI--------------GRRNNFALFALGSAISILLYffLPLSPTLILILGFPLGFFASGPf 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242782825 448 GNMFFFMPmmgylvDAY--TIYAASALAANTVLRSIGGGLLPLAGqsmYKSLGYGWGNSLLGFIMIGFTPVVL 518
Cdd:cd17371  318 SGMGAYLT------ELFptAVRATAQGFCYNVGRIIGALFPFLVG---FLATSGSLGTAIAVFAAVYYIAGLV 381
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 130-282 2.58e-12

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 68.37  E-value: 2.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 130 ETNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGG 209
Cdd:cd17315   30 GLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVP 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242782825 210 GTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKW-IFWVLAIASGVITVGHIIFCHETSAVVI 282
Cdd:cd17315  110 LYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWrLMFALAAVPALLQLLLMFFLPESRALLV 183
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 119-268 4.21e-12

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 68.03  E-value: 4.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 119 PGVAQ-VSSDFNeTNPLLQALVVSIYVIGLAI-GPLVqAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFF 196
Cdd:cd17328   19 AGVLPdIQSDFL-IDDSLAGLLQTVFIISYMVlSPIF-GYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242782825 197 AGcFGSAPV-TIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSE-GWKWIFWVLAIAsGVITV 268
Cdd:cd17328   97 VG-IGEASYsPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVL-GVLLA 168
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 91-268 1.13e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 66.45  E-value: 1.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  91 WTLLKKWTNVGLISAITFIVPLASSMFAPGVAQVSSDFNETNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATC 170
Cdd:cd17325  192 LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 171 NILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSE 250
Cdd:cd17325  272 LLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351

                        170
                 ....*....|....*...
gi 242782825 251 GWKWIFWVLAIASGVITV 268
Cdd:cd17325  352 GFATPFLAAAALLLLAAV 369
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
137-277 1.19e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 66.43  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 137 ALVVSIYVIGLAIGPLVQAPMSEVYGR--WIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIAD 214
Cdd:COG2271  219 GLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE 298

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242782825 215 LFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITVGHIIFCHET 277
Cdd:COG2271  299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 103-282 1.96e-11

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 65.75  E-value: 1.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 103 ISAITFIVPLASSMFAPGVAQVSSDFNeTNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACA 182
Cdd:cd17476    3 ISGAQLLNQAGLGSVIVILPIIGDSFG-TSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 183 VSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPP-QQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAI 261
Cdd:cd17476   82 FSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAI 161

                        170       180
                 ....*....|....*....|..
gi 242782825 262 ASGVITVGHII-FCHETSAVVI 282
Cdd:cd17476  162 LAAIVAVAAIFwTSPSFIAVLL 183
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 103-292 7.45e-11

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 63.77  E-value: 7.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 103 ISAITFIVPLASSMFAPGVAQVSSDFNETnPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACA 182
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHDLGGS-EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 183 VSSNISMLIVFRFFAGcFGSAPVTIGGGTI-ADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAI 261
Cdd:cd17489   80 LATSVALLLVLRLIHG-IGWGAFTTAAATLvADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158

                        170       180       190
                 ....*....|....*....|....*....|.
gi 242782825 262 ASgVITVGHIIFCHETSAVVILNRKVKRLQK 292
Cdd:cd17489  159 LA-LLALLLVFLVKDPPPVAAEEAEAGTRAF 188
Sugar_tr pfam00083
Sugar (and other) transporter;
124-521 8.83e-11

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 64.22  E-value: 8.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  124 VSSDFNETNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVS---SNISMLIVFRFFAG-- 198
Cdd:pfam00083  36 KSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGig 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  199 ---CFGSAPVtigggTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFL---SQSEGWKWIFWVLAIASGVITVGhII 272
Cdd:pfam00083 116 vggASVLAPM-----YISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLnktSNSDGWRIPLGLQLVPALLLIIG-LL 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  273 FCHETSAVVILNRKVKR----LQKETGNMNLRSKLDRQISNTEV---LKRAIVRPAKLTILSPISVLMSVSTAVVygnly 345
Cdd:pfam00083 190 FLPESPRWLVEKGRLEEarevLAKLRGVPDVDRELDEIKDSLEAgqeAEKASWKELFSTKTRRQRLLIGVMLQIF----- 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  346 LMLTTITAVFevsyGWSTGI--------SGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpeDRLPLMLLSGPA 417
Cdd:pfam00083 265 QQLTGINAIF----YYSTTIfenlglsdSFLVTIIVGVVNFVFTFIAIFLVDRF--------------GRRPLLLLGAAG 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  418 IAAGMFWYGWSAKAQTHwiVPILGSSLVGAGNMFFFM-------PMMGYLVD--AYTIYAASALAANTVLRSIGGGLLPL 488
Cdd:pfam00083 327 MAICFVILGIVALLGVS--KSDWAGIVAIVFIALFIAffamgwgPVPWVIVSelFPLSVRSKAMALATAANWLANFLIGF 404

                         410       420       430
                  ....*....|....*....|....*....|...
gi 242782825  489 AGQSMYKSLGYGWGNSLLGFIMIGFTPVVLFIY 521
Cdd:pfam00083 405 LFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFV 437
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 102-487 4.49e-10

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 61.82  E-value: 4.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 102 LISAITFIVPLASSMFAPGVAQVSSDFNETNPLLQA---LVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFT 178
Cdd:cd17358    6 VANLGSFSFGIAVGWSSPALPSLMSDNSLSLPLTVAqfsWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 179 VACAVSSNISMLIVFRFFAG-----CFGSAPVTIggGTIAdlfPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSqsegWK 253
Cdd:cd17358   86 LLIAFAKDVWMLYLGRFLAGfgggaASVVVPVYI--AEIA---PKNVRGALGSLNQLLVNIGILLGYVLGSFLP----WR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 254 WIFWVLAIASGVITVGhIIFCHETSAVVILNRKVKR----LQKETGNMNLRSKLDRQISNTEVLKRAIVRPAKLTILSPI 329
Cdd:cd17358  157 TLALIGAIPPVVFLIL-LFFIPESPRWLAKKGREEEaeksLQFLRGKDADISKEAAEIQEELAELEKEAKESSFSDLFQR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 330 SVLMSVSTAVVygnlyLM----LTTITAV-------FEVSYgwSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksak 398
Cdd:cd17358  236 KYLKPLVIGLG-----LMlfqqLSGINAVifyassiFDEAG--SGLDPNTATIIIGVVQVVGTLVATLLVDRL------- 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 399 glqlkpeDRLPLMLLSgpaiAAGMFwygwsakaqthwivpiLGSSLVGAgnmFFFMPMMGYLVDAYTIYAASALAANTVL 478
Cdd:cd17358  302 -------GRRPLLLVS----AIGMG----------------IGLLALGL---YFYLQEHGALLSSVSWLPLVGLVIYIIS 351


                 ....*....
gi 242782825 479 RSIGGGLLP 487
Cdd:cd17358  352 FSIGLGPLP 360
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 135-261 1.19e-09

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 59.90  E-value: 1.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 135 LQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGcFGSAPVTIGGGTIA- 213
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVG-VTSAGIFTVGFVLGm 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 242782825 214 DLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQsegWKWIFWVLAI 261
Cdd:cd17317  105 EIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLAISL 149
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 100-449 1.21e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 60.28  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 100 VGLISAITFIVpLASSMFAPGVAQVSSDFNETNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTV 179
Cdd:cd17473    2 ITLLLASTLTV-MAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 180 ACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSeGWKWIFWVL 259
Cdd:cd17473   81 AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 260 AIAsGVITVGHIIFCHETsavvilnRKVKRLQKETGNMNLRSKLDRQIsntevlkraivrpakltilSPISVLMSVSTAV 339
Cdd:cd17473  160 LLA-LPVLILVLLFLPEP-------ARKSKSAASPGAATAAALPWKRV-------------------LPIYFLAFLAMLL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 340 vygnLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYLQQKsakglqlkpedrlpLMLLSGPAIA 419
Cdd:cd17473  213 ----FYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR--------------LLAIGFALMA 274

                        330       340       350
                 ....*....|....*....|....*....|
gi 242782825 420 AGMFWYGWsakAQTHWIVpILGSSLVGAGN 449
Cdd:cd17473  275 LGFLLLAL---ASGLWVV-LLGAILAGLGF 300
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 134-261 3.49e-09

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 58.82  E-value: 3.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 134 LLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGcFGsapVTIGGGT-- 211
Cdd:cd17360   35 GWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVG-LG---VGIASMTvp 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 242782825 212 --IADLFPPQQRGRALSLYTLGPVAGPAIGP-IAGGFLSQSEGWKWIFWVLAI 261
Cdd:cd17360  111 lyIAEAAPPRIRGRLVTINVLFITGGQFVAYvINGAFSYLPGGWRWMLGLAAV 163
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
112-261 8.59e-09

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 57.59  E-value: 8.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 112 LASSMFAPGVAQVSSDFNeTNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWivyatcNILY---VVFTVAC---AVSS 185
Cdd:PRK11043  20 LATDMYLPAFKAIQADLQ-TSASAVSASLSLFLAGFALGQLLWGPLSDRYGRK------PVLLaglSLFALGSlgmLWVE 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 242782825 186 NISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSlyTLGPVAG--PAIGPIAGGFLSQSEGWKWIFWVLAI 261
Cdd:PRK11043  93 SAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFA--TIMPLVAlsPALAPLLGAWLLNHFGWQAIFATLFA 168
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 116-277 8.82e-09

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 57.65  E-value: 8.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 116 MFAPGVAQVSSDFNET------NPLLQALVVSIYVIGLaIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISM 189
Cdd:cd17361   28 KFFPSVYEKKKGASENnyckydDQLLQLFTSSLYLAGL-VASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAM 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 190 LIVFRFFAGC---FGSAPVTIgggTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSE--GWKWIFWVLAIASG 264
Cdd:cd17361  107 LIVGRILLGFgvgFGNQAVPL---YLSEMAPAKLRGALNIGFQLAITIGILIANLINYGTSKIKpnGWRLSLGLAAVPAL 183

                        170
                 ....*....|...
gi 242782825 265 VITVGHiIFCHET 277
Cdd:cd17361  184 ILLLGS-LFLPET 195
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 138-268 2.44e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 56.08  E-value: 2.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 138 LVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFP 217
Cdd:cd06173  248 LLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVP 327

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 242782825 218 PQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITV 268
Cdd:cd06173  328 DELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAAL 378
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 105-520 3.70e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 55.26  E-value: 3.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 105 AITFIVPLASSMFAPGVAQVSSDFNETnPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVS 184
Cdd:cd17477    3 LSVALLGLGSGLLLPLLSLRLEREGVS-TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 185 SNISMLIVFRFFAGcFGSAPVTIGGGT-IADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEgwkwiFWVLAIAS 263
Cdd:cd17477   82 DSPWVWFLLRFVMG-IGLAGLFVVSESwLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG-----ALPFLIAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 264 GVITVGhiifchetSAVVILNRKVKRLQKETGNMNLrskldrqisntevlkRAIVRPAKLTILSpisvlmsvstAVVYGN 343
Cdd:cd17477  156 VLLLLA--------LVPLLLTRRAAPEIEEAESISL---------------RRLLRIAPLALLG----------AFVAGF 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 344 LYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpeDRLPLMLLSGpAIAAGMF 423
Cdd:cd17477  203 LEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRF--------------DRRRVLLGCA-LLGALAA 267

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 424 WYGWSAKAQTHWIVPILGssLVGAGNMFFFMPMMGYLVDAYT---IYAASALAanTVLRSIGGGLLPLAGQSMYKSLGyg 500
Cdd:cd17477  268 LLLPLVPGLPLALLVLLF--LWGGAAGPLYTLALALAGDRLPgdeLVAANAAL--LLLYGLGSVIGPLLAGALMDAFG-- 341

                        410       420
                 ....*....|....*....|
gi 242782825 501 wGNSLLGFIMIGFTPVVLFI 520
Cdd:cd17477  342 -PHGLFLFLAAVALLFLLFL 360
PRK10504 PRK10504
putative transporter; Provisional
 132-266 3.81e-08

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 55.89  E-value: 3.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 132 NPLLQALVVSIYVIGLAIGPLVQAPMSEVYG-RWIVYATCnILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGG 210
Cdd:PRK10504  43 SPLHMHMVIVSYVLTVAVMLPASGWLADRVGvRNIFFTAI-VLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRL 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 242782825 211 TIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFwVLAIASGVI 266
Cdd:PRK10504 122 TVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIF-LINIPVGII 176
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 129-414 4.11e-08

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 55.73  E-value: 4.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 129 NETNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVV---FTVACAVSSNISMLIVFRFFAGCFGSAPV 205
Cdd:cd17357   44 DSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVsslLMFLSKSAKSPELLIFGRFLVGIACGLST 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 206 TIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAG--GFLSQSEGWKWIFWVLAIASGVITVGhIIFCHETSAVVIL 283
Cdd:cd17357  124 GFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGlpSVLGTETLWPYLLFFPGIPALLQLAA-LPFFPESPKFLLI 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 284 NRK--------VKRLQKETGN----MNLRSKLDRQISNTEVLK-RAIVRPAKLTIlsPISVLMSVSTAVvygnlylMLTT 350
Cdd:cd17357  203 SKGdeeeaeksLKFLRGIEDDvdqeLEEIKKESEQMGDQKQVSlMQLLRDPSLRL--PLLLVLVVSASQ-------QFSG 273

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 351 ITAVFEVSY------GWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpeDRLPLMLLS 414
Cdd:cd17357  274 INAIFFYSTfifenaGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKV--------------GRRPLLLIS 329
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 138-268 7.10e-08

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 54.65  E-value: 7.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  138 LVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFgSAPVTIGGGTI-ADLF 216
Cdd:TIGR00893  33 YVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYILRVLLGAA-EAPFFPGIILIvASWF 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 242782825  217 PPQQRGRALSLYTLG-PVAGPAIGPIAGGFLsQSEGWKWIFWVLAIASGVITV 268
Cdd:TIGR00893 112 PASERATAVSIFNSAqGLGGIIGGPLVGWIL-IHFSWQWAFIIEGVLGIIWGV 163
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
108-277 1.19e-07

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 54.06  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 108 FIVPLASSMFAPGVAQVSSDFNETNPLLQAlVVSIYVIG-LAIGPLVqAPMSEVYGRWIVYATCNIlyvVFTVACA---V 183
Cdd:PRK15403  26 FAAYLTTDLIQPGIINVVRDFNADVSLAPA-SVSLYLAGgMALQWLL-GPLSDRIGRRPVLITGAL---IFTLACAatlF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 184 SSNISMLIVFRFFAG---CFGSapvTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLA 260
Cdd:PRK15403 101 TTSMTQFLIARFIQGtsiCFIA---TVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIA 177

                        170
                 ....*....|....*..
gi 242782825 261 IASGVITVGHIIFCHET 277
Cdd:PRK15403 178 VMGLIAFVGLLLAMPET 194
emrD PRK11652
multidrug transporter EmrD;
95-277 1.35e-07

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 53.76  E-value: 1.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  95 KKWTNVGLISAITFIVP---LASSMFAPGVAQVSSDFNETNPLLQAlVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCN 171
Cdd:PRK11652   2 KRQRNVNLLFMLVLLVAvgqMAQTIYVPAIADMARDLNVREGAVQA-VMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 172 ILYVVFTVACAVSSNISMLIVFRFFAGcFGSApvtiGGGTIA-----DLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFL 246
Cdd:PRK11652  81 SIFILGTLVALFAHSLTVLIAASAIQG-LGTG----VGGVMArtlprDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLL 155

                        170       180       190
                 ....*....|....*....|....*....|.
gi 242782825 247 SQSEGWKWIFWVLAIASGVITVGHIIFCHET 277
Cdd:PRK11652 156 TTLFGWRACYLFLLLLGAGVTFSMARWMPET 186
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 105-523 3.54e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 52.61  E-value: 3.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 105 AITFIVPLASSMFAPGVAQVSSDFNETNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVS 184
Cdd:cd17329    6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 185 SNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSeGWKWIFWVLAIASG 264
Cdd:cd17329   86 HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 265 VITVGHIIFCHETsavvilnrkvKRLQKETGNMNLRSKLdrqisntevlkRAIVRPAKLTILSPISVLMSVSTAVVYGNL 344
Cdd:cd17329  165 LAALVLLFLLPET----------RPKRRAAEKTEILRGY-----------KIVLRDRAFLLFLLASFLISLIYFQLESTL 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 345 YLMLTTITAVFEVSYGWSTGISGLayigmgvgnVIGLLSFSITsdKYLQQKSakglqlkpedRLPLMLLSGPAIAAGMFW 424
Cdd:cd17329  224 PVYVVEILGLGESLLGLLLALNAL---------LIVLLQFPVA--RLVERFR----------LRKILMIGILLFAIGFAV 282

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 425 YGWSakaqTHWIVPILGSSLVGAGNMFFFmPMMGYLVDAY-------TIYAASALAAntvlrSIGGGLLPLAGQSMYKSL 497
Cdd:cd17329  283 LAFA----NTLAVLILAMIVLTLGEMLVF-PAVQTLVAALappdkrgSYMGFYALAW-----GLGRAIGPLVGGLLLDLL 352

                        410       420
                 ....*....|....*....|....*.
gi 242782825 498 GYGWGnsLLGFIMIGFTPVVLFIYRY 523
Cdd:cd17329  353 GPGLP--WLILAALGLIAAALLLGLQ 376
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 138-426 7.70e-07

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 51.22  E-value: 7.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  138 LVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFP 217
Cdd:TIGR00881  34 LLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  218 PQQRGRALSLYTLGP-VAGPAIGPIAGGFLSQSEGWKWIFWVLAIASgvITVGHIIFchetsaVVILNRKVKRLQKETGN 296
Cdd:TIGR00881 114 RSERGTWVSFWNCSHnVGGGLLPPLVLFGIAELYSWHWVFIVPGIIA--IIVSLICF------LLLRDSPQSCGLPPAEE 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  297 M-NLRSKLDRQISNTEVLKRAIVrpAKLTILSPISVLMSVSTAVVYGNLYLMLTTITAVFEVSYGWSTGISGLAYIGMGV 375
Cdd:TIGR00881 186 MpNEEPDGDAEKKEEELTKKQIF--LQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYEL 263

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 242782825  376 GNVIGLLSFSITSDKYLQQK--------------SAKGLQLKPEDRLPLMLLSGpaIAAGMFWYG 426
Cdd:TIGR00881 264 GGLVGTLLAGWLSDKLFNGRrgplavffmaliivSLLVYWLNPAANPLMDLICL--FALGFLVYG 326
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
108-269 7.90e-07

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 51.48  E-value: 7.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 108 FIVPLASSMFAPGVAQVSSDFNeTNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNI 187
Cdd:PRK15402  23 FATYIANDMIQPGMLAVVEDFN-AGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 188 SMLIVFRFFAG---CFGSApvtIGGGTIADLFPPQQRGRALSLytLGPVA--GPAIGPIAGGFLSQSEGWKWIFWVLAIA 262
Cdd:PRK15402 102 EQFTLLRFLQGiglCFIGA---VGYAAIQESFEEADAIKITAL--MANVAllAPLLGPLVGAALIHVLPWRGMFVLFAAL 176


                 ....*..
gi 242782825 263 SGVITVG 269
Cdd:PRK15402 177 AALSFFG 183
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 138-268 2.28e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.91  E-value: 2.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 138 LVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTV--ACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADL 215
Cdd:cd17316  217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALplFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 242782825 216 FPPQQRGRALSL-YTLGpVAGPAIGPIAGGFLSQSEG----WKWIFWVLAIASGVITV 268
Cdd:cd17316  297 FPTEVRATGVGLsYNLG-RLGGGGAPPLIALLLASTGgtgvPALILALLAIVALIVAL 353
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 132-262 3.71e-06

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 49.27  E-value: 3.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 132 NPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGcFG------SAPV 205
Cdd:cd17362   37 SSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYG-VGiglamhAAPV 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 242782825 206 tigggTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAG-GFLSQSEGWKWIF-WVLAIA 262
Cdd:cd17362  116 -----YIAETSPSHIRGLLVSLKELFIVLGILLGYVSGyAFADVVGGWRYMYgLAAPPA 169
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 103-261 3.90e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 49.14  E-value: 3.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 103 ISAITFIVPLASSMFAPGVAQVSSDFNETNPLLQALVVSIYVIGLAIgplVQAPM---SEVYGRWIVYATCNILYVVFTV 179
Cdd:cd17472    1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAI---FQIPFgllSDRIGRKPVILFGLLLFIAGSL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 180 ACAVSSNISMLIVFRFFAGcfGSAPVTIGGGTIADLFPPQQRGRALSLytLGPVAGPA--IGPIAGGFLSQSEGWKWIFW 257
Cdd:cd17472   78 LAAYATSIYGLILGRALQG--SGAISSVVMALLADLTREENRTKAMAL--IGASIGIAfaISMVLGPLLAAHLGVSGLFL 153


                 ....
gi 242782825 258 VLAI 261
Cdd:cd17472  154 ITAI 157
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 137-473 4.16e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 49.16  E-value: 4.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 137 ALVVSIYVIGLAIGPLVQAPMSEVYG-RWIVYATCNILYVVFTVACAVSSnISMLIVFRFFAGcFGSAPVTIGGGT-IAD 214
Cdd:cd17475   34 GLLLSALNLGVAVSMLPAGWLLDRFGeRRVLAVGLLLMGAAALLMALVGS-YPVLLVLLFLVG-AGYGSVQPGGGRaIMR 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 215 LFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITVGHIIFCHEtsavvilnRKVKRLQKET 294
Cdd:cd17475  112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYRE--------PPAASAATES 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 295 GNMNLRSKLdrqisntEVLKRAIVRPAKLTILSPISVLMSVSTavvygnlYLMLTTITAVfevsyGWSTGISGLAYIGMG 374
Cdd:cd17475  184 ASTLLRSLK-------EVLRNRDVWLIAIAGALLVAPQFALLT-------FLLLFLHDHL-----GLSVVAAGALLAVAQ 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 375 VGNVIGLLSFSITSDKYLQQKSAKGLQ-------------LKPEDRLPLMLLSGPAIAAGMFWYGWSAKAQThWIVPILG 441
Cdd:cd17475  245 LGGALGRIGLGRVSDRVFGGRRRPVLVitaaiaaaallvlSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLT-LVAESAG 323

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 242782825 442 SSLVGA----GNMFFFM------PMMGYLVDAYTIYAASALA 473
Cdd:cd17475  324 PEQAGTalglANTINFIgiaigpPLFGLLVDATHSYAPAWLA 365
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
102-488 4.44e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 49.08  E-value: 4.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 102 LISAITFIVPLASSMFAPGVAQVSSDFNETNPLLqALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVAC 181
Cdd:COG0738   12 AIYLLFFLWGFATALWGPLIPALKDAFGLSDAQA-GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 182 AVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFpPQQRGRALSL----YTLGPVAGPAIGPIAgGFLSQSEGWKWIFW 257
Cdd:COG0738   91 ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLlhafFSLGALLGPLLGGLL-ILLGLSLSWHLPYL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 258 VLAIASGVItvghiifchetsAVVILNRKVKRLQKETGNmnlrsKLDRQISNTEVLKRaivrpaKLTILSPISVLMSVST 337
Cdd:COG0738  169 ILAVLLLLL------------ALLFLRSKLPEIEEEEEE-----AAGSAASLKSLLKN------PRLLLGGLAIFLYVGA 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 338 AVVygnlylMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpeDRLPLMLLSGPA 417
Cdd:COG0738  226 EGA------IGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF--------------GPVRLLRLSALL 285

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 242782825 418 IAAGMFWYGWSakaqTHWIVPILGSSLVGAGNMFFFMPMMGYLVDAYTIYAASALAANTVLRSIGGGLLPL 488
Cdd:COG0738  286 AAVGLLLALLA----PGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPP 352
MFS_efflux_LmrB NF000060
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters ...
 147-258 6.65e-06

lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters Lmr(B) expression in Bacillus subtilis and allows Lmr(B) to confer resistance to lincomycin.


Pssm-ID: 411077 [Multi-domain]  Cd Length: 479  Bit Score: 48.87  E-value: 6.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 147 LAIGPLVqaPMSEVYGRWI----VYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRG 222
Cdd:NF000060  63 LVLGILV--PVSGLLLQWFttrqLFTVSLIFSILGTFIAALAPSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRG 140

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 242782825 223 RALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWV 258
Cdd:NF000060 141 AAMGTIGLVIMFAPAIGPTFSGLVLEHLNWHWIFWI 176
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 131-520 7.90e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.38  E-value: 7.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 131 TNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAV-----SSNISMLIVFRFFAGCFGSAPV 205
Cdd:cd06173   31 GSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLAFLLGIASAFFG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 206 TIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVitvghiifchetSAVVILnr 285
Cdd:cd06173  111 PARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLL------------SALLLL-- 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 286 kvkRLQKETGNMNLRSKLDRQISNTEVLKRAIVRPAKLTILSPISVLMSVSTAvvygnlylMLTTITAVFEVSYGWSTGI 365
Cdd:cd06173  177 ---FIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGA--------LTVLLPLLAKEVLGGGAAG 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 366 SGLAYIGMGVGNVIGllsfSITSDKYLQQKSakglqlkpedRLPLMLLSGPAIAAGMFWYGWSakaqTHWIVPILGSSLV 445
Cdd:cd06173  246 YGLLLAAFGVGALLG----ALLLGRLSKRRR----------RGRLLLIGALLLGLALLVLGLS----PSLWLLLAALFLL 307

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 242782825 446 GAGNMFFFMPMMGYL---VDAYtiYAASALAANTVLRSIGGGLLPLAGQSMYKSLGYGWGNSLLGFIMIGFTPVVLFI 520
Cdd:cd06173  308 GLAGGLFNVPLNTLLqlrVPDE--LRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 132-266 8.20e-06

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 47.99  E-value: 8.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 132 NPLLQALVVSIY-VIGLAIGPLVqAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSApVTIGGG 210
Cdd:cd17390   29 SPTVIGLIGSVYgALQLFSSPLV-GSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHT-QSLCKA 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 242782825 211 TIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWkwiFWVLAIASGVI 266
Cdd:cd17390  107 YLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGG---FYYVALLCSAI 159
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 137-273 1.12e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.59  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 137 ALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLF 216
Cdd:cd17489  230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLV 309

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 242782825 217 PPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFwvlAIASGVITVGHIIF 273
Cdd:cd17489  310 PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMF---LLAAVVVLLALVLY 363
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 138-390 1.14e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 47.63  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 138 LVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSA--PVTIggGTIADL 215
Cdd:cd17327   45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGvfPGFI--LYLGMW 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 216 FPPQQRGRALSLYtlgpVAGPAIGPIAGGFLSQS----------EGWKWIFWVLAIASGVITV-GHIIFCHETSAVVILN 284
Cdd:cd17327  123 YKREEQAKRIAFF----YAAAGLGSIFGGLLAYGvfkilgvgglAGWRWLFIIEGLITIIIGLvIFFWLPDNPSKAWFLT 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 285 RKVKRLQKETGNMNLRSKLDRQISNTEVLKraivrpaklTILSPISVLMSVSTAVVYGNLYlMLTTITAVFEVSYGWSTG 364
Cdd:cd17327  199 EEEKELAVERLRANQTGKGDQKFKWKQIKE---------AFKDPRTWLLFLFFFCSQITNN-GISNFLPLILKSLGFYSL 268

                        250       260
                 ....*....|....*....|....*.
gi 242782825 365 ISGLAYIGMGVGNVIGLLSFSITSDK 390
Cdd:cd17327  269 QTNLLSVPIGALGAVSLLIAALLSDR 294
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 107-289 1.36e-05

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 47.74  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  107 TFIVPLASSMFAPGVAQvssDFNETNPllQALVVSIYVIGLAIGPLVQAPMSEVYGRW-IVYATCNILYVVFTVACAVSS 185
Cdd:pfam06609  56 TYFVLQASASALPNILQ---DIGQSEN--QGLFSTLWTMGQAVSILMMGRLTDRFGRRpFVIATHIIGLVGAIVGCTANK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  186 NISMLIVFRFF---AGCFGSAPVTIGggtiaDLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIA 262
Cdd:pfam06609 131 FNTLLAAMTLLgvaAGPAGASPLFIG-----ELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIM 205

                         170       180
                  ....*....|....*....|....*..
gi 242782825  263 SGVITVGHIIFCHETSAVVILNRKVKR 289
Cdd:pfam06609 206 SAIAVLLIIIWYHPPSFAQLHGKKARK 232
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 135-207 1.68e-05

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 46.90  E-value: 1.68e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242782825 135 LQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGcFGSAPVTI 207
Cdd:cd17374   36 LKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAG-FAVSGISI 107
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
102-522 1.96e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.18  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 102 LISAITFIVPLASsmFAPGVAQVSSDFNETNPLLqALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVAC 181
Cdd:COG2807   24 VLVALNLRPAITS--VGPLLPEIRADLGLSATQA-GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLR 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 182 AVSSNISMLIVFRFFAGC-FGSAPVTIGGgTIADLFPpQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLA 260
Cdd:COG2807  101 SLAPSVALLLAGTALIGAgIAVGNVLLPG-LIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 261 IASGVITVGHIIFCHETSAvvilnrkvkrlqketgnmnlrsklDRQISNTEVLKRAIVRPAKLTILSPISVLMSVSTAVV 340
Cdd:COG2807  179 LLALLALLLWLPLLRRRPA------------------------AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAV 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 341 YGNLYLMLttitavfeVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpEDRLPLMLLSGPAIAA 420
Cdd:COG2807  235 VAWLPPIL--------RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL-------------GDRRPLLLLLGLLGLA 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 421 GMFWYGWsakAQTHWivPILGSSLVGAGNMFFFmPMMGYLVDAYTIYAASALAANTVLRSIG---GGLLPLAGQSMYKSL 497
Cdd:COG2807  294 GLLGLLL---APGSL--PWLWAVLLGLGQGGLF-PLALTLIGLRARTPAEAAALSGMAQSVGyllAALGPLLVGALHDAT 367

                        410       420
                 ....*....|....*....|....*.
gi 242782825 498 G-YGWGNSLLGFIMIGFTPVVLFIYR 522
Cdd:COG2807  368 GsWTAALLLLAALAVLMLVAGLLAGR 393
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 106-239 2.67e-05

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 46.47  E-value: 2.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 106 ITFIVPLASSMFAPGVAQVSS---------------DFNETNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGR-WIVYAT 169
Cdd:cd17356    2 LCAFVSLGGFLFGYDTGSISGilnmksfqkyfadntGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRkKSIQIG 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 242782825 170 CNILYVVFTVACAVSSNISMLIVFRFFAG-CFGSAPVTIgGGTIADLFPPQQRGRALSLYTLGPVAGPAIG 239
Cdd:cd17356   82 CVIYIIGAIIQVAAIGKWYQLIVGRIIAGlGVGFASVLV-PVYQSEVAPKHIRGTLVSLYQLAITIGILVA 151
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 136-273 3.15e-05

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 46.33  E-value: 3.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 136 QALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADL 215
Cdd:cd17435   38 QEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEI 117

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 242782825 216 FPPQQRGRALSLYTLGPVAGPAIGPIAG-GFLSQSEGWKWIFWvLAIASGVITVGHIIF 273
Cdd:cd17435  118 APQHRRGLLVSLNELMIVIGILLAYISNyAFANVSNGWKYMFG-LVIPLAALQAIAMYF 175
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 118-258 3.70e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 46.11  E-value: 3.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 118 APGVAQvssDFNETNPLLqALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFA 197
Cdd:PRK11551  38 APRMAQ---EFGLDVAQM-GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLT 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242782825 198 GC-FGSA-PVTIGggTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWV 258
Cdd:PRK11551 114 GVgLGGAlPNLIA--LTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYV 174
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 95-273 3.70e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.03  E-value: 3.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  95 KKWTNVGLISAITFIVPLASSMFAPGVAQVSSDFNETNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILY 174
Cdd:cd17473  194 LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALM 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 175 VVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKW 254
Cdd:cd17473  274 ALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLS 353

                        170       180
                 ....*....|....*....|
gi 242782825 255 -IFWVLAIASGVITVGHIIF 273
Cdd:cd17473  354 gAFLILGVLALVLAIVLLLL 373
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 132-273 7.46e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 45.30  E-value: 7.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 132 NPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNIS--MLIVFRFFAGCFGSAPVTIGG 209
Cdd:cd17318   54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGygALIVLRILQGLAQGVTFPAMH 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242782825 210 GTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVlaiaSGVITVGHIIF 273
Cdd:cd17318  134 ALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYI----FGGLGLLWCLL 193
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 182-520 8.81e-05

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 44.87  E-value: 8.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 182 AVSSNISMLIVFRFFAGcFGSAPVTIGG-GTIADLFP-PQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVL 259
Cdd:cd17384   79 AFGESYGVLFLARALQG-VGSACSSVAGmGMLASLYPdDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLIL 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 260 AIAsgvitvghiIFCHETSAVVILNRKVKRLQKETGNmnlrskldrqiSNTEVLKRaivrpaKLTILSPISVLMSVST-A 338
Cdd:cd17384  158 AFL---------ALLDGALQLFILQPSVKSEESEEGT-----------PWKTLLKD------PYILIAAGAICFSNSGiA 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 339 VVYGNLYL-MLTTITAVfevsyGWSTGIsglAYIGMGVGNVIGLLSFSITSDKYLQQKSAkglqlkpedrLPLMLLSGPA 417
Cdd:cd17384  212 ILEPCLPIwMMETMCPP-----KWQLGT---AFLPDSIGYLIGTNLFGPLAHKIGRWLCS----------LLGMLLVGIS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 418 IAAGMFwygwsAKAQTHWIVPI----LGSSLVGAGnmffFMPMMGYLVDA-----Y-TIYAASALAAntvlrSIGGGLLP 487
Cdd:cd17384  274 LILIPL-----AKNIYGLIIPHfglgLGIGMVDSS----MMPLLAYLVDLrhssvYgSVYAIADVAF-----CLAFALGP 339

                        330       340       350
                 ....*....|....*....|....*....|...
gi 242782825 488 LAGQSMYKSLGYGWGNSLLGFIMIGFTPVVLFI 520
Cdd:cd17384  340 SLGGAIVKSIGFPWLMRIIGIINILYAPLLFFL 372
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 102-274 1.07e-04

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 44.55  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 102 LISAITFIVPLAS-SMFAPGVAQVSSDFNETnPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVA 180
Cdd:cd17341    2 HLSWLSFFLGFMVwFLFAPLGPVIRDDLGLS-TSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 181 CAVS-SNISMLIVFRFFAGcFGSAPVTIGGGTIADLFPPQQRGRALSLY----TLGPVAGPAIGPI---AGGFLSQSEGW 252
Cdd:cd17341   81 LALAvSSYWGLLVLGFLLG-FAGANFASGQPWASFWFPKEKIGGAAGGIagagNMGVAVSQLLAPLiagAIVFDGGFVGW 159

                        170       180
                 ....*....|....*....|..
gi 242782825 253 KWIFWVLAIASGVITVGHIIFC 274
Cdd:cd17341  160 RNAFFVPGILLAIAAVLVLLFG 181
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
88-260 1.33e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 44.53  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  88 PMNW--TLLKKWTNVGLI-SAITFIVPlassmFAP-GVAQVSSDFNETNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGR 163
Cdd:PRK09874   9 PINWkrNLTVAWLGCFLTgAAFSLVMP-----FLPlYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 164 WIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSApVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAG 243
Cdd:PRK09874  84 KIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGF-VPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAG 162

                        170
                 ....*....|....*..
gi 242782825 244 GFLSQSEGWKWIFWVLA 260
Cdd:PRK09874 163 GLLADSYGLRPVFFITA 179
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 137-275 1.39e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 44.23  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 137 ALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLF 216
Cdd:cd17333   34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242782825 217 pPQQRGRALSL----YTLGPVAGPaigPIAGGFLSQSEGWKWIFWVLAiASGVITVGHIIFCH 275
Cdd:cd17333  114 -EESSATRLNVlhgfFGLGALIGP---LIATSLLTSELSWSWAYLIIG-LIYLLLAILILLTL 171
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
161-520 2.13e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.74  E-value: 2.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 161 YGR---WIVYATcnILYVVFTVACAVSSNIS------MLIVFRFFAGCFGSAPVTIGGGTIADLFP-PQQRGRALSLYTL 230
Cdd:COG2211   77 WGRrrpWILIGA--IPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFA 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 231 GPVAGPAIGPIAGGFL------SQSEGWKWIFWVLAIASGVITVGHIIFCHEtsavvilnrkvkRLQKETGNMNLRSKLd 304
Cdd:COG2211  155 FAGLGGLLASVLPPPLvaafggDAALGYRLTALIFAVLGLLAFLLTFFGTKE------------RPVPEEEKVSLKESL- 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 305 rqisntevlkRAIVRPAKLTILSPISVLMSVSTAvvygnlyLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSF 384
Cdd:COG2211  222 ----------KALLKNRPFLLLLLAYLLFFLALA-------LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLW 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 385 SITSDKYlqqksakglqlkpeDRLPLMLLSGPAIAAGMFWYGWSAKAQTHW-IVPILGSSLVGAGNMFFFMPMMGYLVDA 463
Cdd:COG2211  285 PRLAKRF--------------GKKKAFIIGLLLAALGLLLLFFLGPGNLWLlLVLAALAGIGLGAILVLPWAMLADVVDY 350

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 242782825 464 YTIY-----AASALAANTVLRSIGGGLLPLAGQSMYKSLGYGWG-----NSLLGF-IMIGFTPVVLFI 520
Cdd:COG2211  351 DEWKtgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGaaqspSALTGIrLLFFLLPAVLLL 418
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
137-268 2.23e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.69  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 137 ALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSA--PVTIgggTIAD 214
Cdd:COG0738  249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLmfPTIF---SLAL 325

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 242782825 215 LFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITV 268
Cdd:COG0738  326 DGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILL 379
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 131-209 3.23e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 43.04  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 131 TNPLLQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSN------ISMLIVFRFFAGcFGsap 204
Cdd:cd17364   36 LPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLG-IG--- 111


                 ....*
gi 242782825 205 vtIGG 209
Cdd:cd17364  112 --IGG 114
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 182-245 5.71e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 42.24  E-value: 5.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 242782825 182 AVSSNISMLIVFRFFAGCFGsAPVTIGGGTIADLFPPQQRGRALSL----YTLGPVAGPAIGPIAGGF 245
Cdd:cd17388   86 AFAPTLWWLYLGRIIAGITG-ATGAVAAAYIADVTPPEQRARNFGLlgaaFGLGFIAGPALGGLLGEI 152
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 165-268 7.99e-04

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 41.84  E-value: 7.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 165 IVYATCNILYVVFTVAcavSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTL-----GPVAGPAIG 239
Cdd:cd17345   76 ILSAIINILIGFVPSA---TSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNIshnvgGGLVGPLAG 152

                         90       100
                 ....*....|....*....|....*....
gi 242782825 240 PIAGGFLSQSegWKWIFWVLAIASGVITV 268
Cdd:cd17345  153 LGLAIFGDGW--WRGAFIFPAIIAIIVAV 179
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 135-268 8.68e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 41.74  E-value: 8.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 135 LQALVVSIyVIGLAIGPLVqAPMSEVYGRWIVYATCNILYVVFTVAC--AVSSNISMLIVFRFFAGCFGSAPVTIG--GG 210
Cdd:cd17369  267 LLAVLIAS-VVAAITIPLF-GWLSDRVGRRPVYLAGALLAALFAFPFfwLLDTGSTWLIVLAAVVVLGVLHGMMYGpqAA 344

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 211 TIADLFPPQQRGRALSL-YTLGPVAGPAIGP-IAGGFLSQSEGWKWIFWVLAIASgVITV 268
Cdd:cd17369  345 FLAELFPTRVRYTGASLgYQLGAILGGGFAPlIATALVAATGSWWPVALYLAALA-VISL 403
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 172-265 1.02e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 41.38  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 172 ILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPpQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEG 251
Cdd:cd17471  273 LAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMP-GQPGLATTLYSNASRIGSLLGGLLAGVIAQYFG 351

                         90
                 ....*....|....
gi 242782825 252 WKWIFWVLAIASGV 265
Cdd:cd17471  352 YRAVFLVCAVLALL 365
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 151-273 1.07e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 41.49  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 151 PLVQApMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGcFGSAPVTIGGGTIADLFPPQQRGRALSL--- 227
Cdd:cd17389   82 PITGA-ASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGG-ISKGNVSLSTAIVADVTSPKKRSKGMALigv 159

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 242782825 228 -YTLGPVAGPAIGpiaGGFLSQSEGWKWIFWVL-AIASGVITVGHIIF 273
Cdd:cd17389  160 aFSLGFIIGPMIG---AYFASFTRSLGEVFFSMpALFALVLALADLLF 204
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 135-229 1.13e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 41.54  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  135 LQALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIAD 214
Cdd:TIGR00898 128 KVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTE 207

                          90
                  ....*....|....*
gi 242782825  215 LFPPQQRGRALSLYT 229
Cdd:TIGR00898 208 FLPKKQRAIVGTLIQ 222
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 171-268 1.33e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 41.14  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 171 NILYVVFTVACAVSSNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAI-GPIAGGFLSQS 249
Cdd:cd06180   71 LLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALsGLLVPAGLGGG 150

                         90
                 ....*....|....*....
gi 242782825 250 EGWKWIFWVLAIASGVITV 268
Cdd:cd06180  151 LSWRAGWLALALLSAVLLL 169
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 137-277 1.52e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 41.13  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 137 ALVVSIYVIGLAIGPLVQAPMSEVYGR-------WIVYATCNILYVVFTVacavssNISMLIVFRFFAGCFGSAPVTIGG 209
Cdd:cd17371  248 AGYLVVTILGGFLGYLAGGFLADRIGRrnnfalfALGSAISILLYFFLPL------SPTLILILGFPLGFFASGPFSGMG 321

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242782825 210 GTIADLFPPQQRGRALS-LYTLGPvAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITVGHIIFCHET 277
Cdd:cd17371  322 AYLTELFPTAVRATAQGfCYNVGR-IIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 176-459 1.58e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.00  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 176 VFTVACAVSSNISMLIVFRFFAGcFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWI 255
Cdd:cd17478   73 LGLSLLGFAPNYWLLLLLVALAG-IGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 256 FWVLAIAsgvitvghiifcheTSAVVILNRKVKRLQKETgnmnlRSKLDRQISNTEVLKraivrpAKLTILSPISVLMSV 335
Cdd:cd17478  152 LILLIIP--------------GLAVALLLLRLRPLKKPE-----AKKAAAKSSARSTLK------GVWRALLLLLIIVFL 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 336 STAVVYGnlylmLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpeDRLPLMLLSg 415
Cdd:cd17478  207 RSWVLSS-----LTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRF--------------GRRRVIIAS- 266

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 242782825 416 paIAAGMFWYGWSAKAQTHWIVPILGssLVGAGNMFFFMPMMGY 459
Cdd:cd17478  267 --LLLAAPFLLLFLLTPGIWSYILLV--LAGFLLFASFPVTVVL 306
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 107-276 1.86e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.71  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 107 TFIVPLASSMFAPGVAQVSSDFNETNP----LLQALVVSIYVIGLAIGPLVQAPMSEVYGR--WIVYATCNILYVVFTVA 180
Cdd:cd17391    5 NFFTGIGFSLIAPFLPLYIEQLGVTSGglveLWSGLAFSSTFLVSAIFSPIWGRLADRYGRkpMLLRASLGMAIVIGLMA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 181 CAvsSNISMLIVFRFFAGCFG---SAPVTIgggtIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFW 257
Cdd:cd17391   85 FV--TNVWQLLILRLLQGVFSgyvPNATAL----IASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFF 158

                        170
                 ....*....|....*....
gi 242782825 258 VLAIASGVITVGHIIFCHE 276
Cdd:cd17391  159 ITGGLLFLAFLLTLFFVKE 177
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 137-268 2.01e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 40.72  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 137 ALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAV----SSNISMLIVFRFFAGCFGSAPVTIGGGTI 212
Cdd:cd17312  222 GWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALfwffPHNKLLSIVLLFLIGFFVGGPINLIGGAA 301

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 242782825 213 ADLFPPQQ-RGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITV 268
Cdd:cd17312  302 AQDIGRKEaAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVL 358
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 132-276 2.47e-03

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 40.50  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  132 NPLLQALVVSIYVIGLAIGPLVQAPMSEVY--GRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGcFGSAPVTIG- 208
Cdd:TIGR00894  74 SGALQGLILSSHFYGQIIIQIPVGYLAGKYvfKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQG-LAQGSVSPAt 152

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242782825  209 GGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSE-GWKWIFWVLAIASGVITVGHIIFCHE 276
Cdd:TIGR00894 153 HKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPAD 221
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 137-268 3.06e-03

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 39.83  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 137 ALVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVSSNISMLIVFRFFAGCfGSAPVTIGGGTIADLF 216
Cdd:cd17372   37 ALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGL-GLGGGPQLASWYLEFL 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 242782825 217 PPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITV 268
Cdd:cd17372  116 PAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLV 167
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 80-262 5.29e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 39.12  E-value: 5.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  80 DSEDDPANPMNWTLLKKWT--NVGLISAITFIVPLASSMFAPGVAQVSSDF----NETNPLLQAL--VVSIYVIGLAIGP 151
Cdd:cd17331  187 ESASPPSVFNLKEILRLLRlpGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFfgltPEENGYLMSYagVLGMVVQGLLVGP 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 152 LvqapmSEVYGRWIVYATCNILYVV-FTVACAVSSNISMLIVFRFFAgCFGSAPVTIGGGTIADLFPPQQRGRALSL-YT 229
Cdd:cd17331  267 L-----TKRFGERSLLKLSVALLAIgYLLLAFVTTVWQLLVLLLPLV-IGGSVLYTVITSLLTKAVPPEDTGTALGLsHA 340

                        170       180       190
                 ....*....|....*....|....*....|...
gi 242782825 230 LGPVAGpAIGPIAGGFLSQSEGWkWIFWVLAIA 262
Cdd:cd17331  341 LFSLVR-TVSPTIGGALLQAYGF-PSFGLLGAA 371
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 172-266 5.62e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.13  E-value: 5.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 172 ILYVVFTVACAV----SSNISMLIVFRFFAGCFGSAPVTIgggTI--ADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGF 245
Cdd:cd17490   66 IIGLLFTVLASLimilFPSPWGLLIARFLSGIAAATWVSF---TVlyASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGL 142

                         90       100
                 ....*....|....*....|.
gi 242782825 246 LSQSEGWKWIFWVlAIASGVI 266
Cdd:cd17490  143 IAEHFGMRAPFLL-AALAGVL 162
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 145-263 5.77e-03

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 39.09  E-value: 5.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 145 IGLAIGPLVQAPMSEVYGRWIvyatCNILYVVFTVACAV----SSNISMLIVFRFFAGcFG-----SAPVTIGGgTIADL 215
Cdd:cd17384  241 IGYLIGTNLFGPLAHKIGRWL----CSLLGMLLVGISLIliplAKNIYGLIIPHFGLG-LGigmvdSSMMPLLA-YLVDL 314

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 242782825 216 FPPQQRGralSLYTLGPVA---GPAIGPIAGGFLSQSEGWKWIFWVLAIAS 263
Cdd:cd17384  315 RHSSVYG---SVYAIADVAfclAFALGPSLGGAIVKSIGFPWLMRIIGIIN 362
MFS_1 pfam07690
Major Facilitator Superfamily;
333-519 7.11e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.94  E-value: 7.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  333 MSVSTAVVYGNLYLMLTTITAVFEVSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpeDRLPLML 412
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF--------------GRRRVLL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825  413 LSGPAIAAGMFWYGWSAkaqTHWIVpILGSSLVGAGNMFFFMPMMGYLVDAYTIYA-ASALAANTVLRSIGGGLLPLAGQ 491
Cdd:pfam07690  67 IGLLLFALGLLLLLFAS---SLWLL-LVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGG 142

                         170       180
                  ....*....|....*....|....*...
gi 242782825  492 SMYKSLGYGWGNSLLGFIMIGFTPVVLF 519
Cdd:pfam07690 143 LLASLFGWRAAFLILAILSLLAAVLLLL 170
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 132-391 8.37e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 38.79  E-value: 8.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 132 NPLLQALVVSIYVIGLA--IGPLVQAPMSEVYGRWI-------VYATCNILYVVFTVACAVSSNISMLIVFRFFAGCFGS 202
Cdd:cd17355   27 IPIIAEFGWSRAVISLAftVGLLAFGLAQPFVGRLLdrfgprrVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 203 APVTIGGG-TIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASGVITVghiifchetSAVV 281
Cdd:cd17355  107 GTLAAVAFaTVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLV---------PVLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 282 ILNRKVKRLQKETGnmnlrsKLDRQISNTEVLKRAIVRPAKLTILSPIsvlmSVSTAVVYGnlyLMLTTITAVfeVSYGW 361
Cdd:cd17355  178 LLRRRPADLALRAY------DDASPASPGSTLKEALRSASFWLLALAF----FLCGFAVVG---LIVHLVPYL--ADRGI 242

                        250       260       270
                 ....*....|....*....|....*....|
gi 242782825 362 STGISGLAYIGMGVGNVIGLLSFSITSDKY 391
Cdd:cd17355  243 SPAAAAVALALIGLFNIVGRLLSGWLGDRY 272
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
105-277 8.62e-03

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 38.46  E-value: 8.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 105 AITFIVPLASSMFAPGVAQVSSDFNETNPLLQaLVVSIYVIGLAIGPLVQAPMSEVYGRWIVYATCNILYVVFTVACAVS 184
Cdd:PRK10473  10 ALVLLYPAGIDMYLVGLPRIAADLNASEAQLH-IAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 185 SNISMLIVFRFFAGCFGSAPVTIGGGTIADLFPPQQRGRALSLYTLGPVAGPAIGPIAGGFLSQSEGWKWIFWVLAIASG 264
Cdd:PRK10473  89 ETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGI 168

                        170
                 ....*....|...
gi 242782825 265 VITVGHIIFCHET 277
Cdd:PRK10473 169 LVLLLSLFILKET 181
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
 163-518 8.63e-03

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 38.75  E-value: 8.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 163 RWIVyaTCNILYVVFTVACA---VSSNISMLIVFrFFAGCFGSAPVTIG-GGTIADLFPPQQRGRALSLYTLGPVAGPAI 238
Cdd:cd17485   67 SWLL--PTQLGLALLLLALAflpPTTNLLAFLGL-LFLLNLFSATQDIAtDGLAVELLTPEERGLGNAAQVVGYKLGSLL 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 239 GpiAGGFLSQSE--GWKWIFWVLAIASGVITVghiifchetsaVVILNRKVKRLQKETGNMNLRSKLDRqisntevLKRA 316
Cdd:cd17485  144 G--GGGLLWLYDliGWQSLLLSLAALYLLLLL-----------PVLFLRELELPQQPPASERGAALKAS-------LRAF 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 317 IVRPAKLTILSPISVLMSVStAVVYGNLYLMLttitavfeVSYGWStgisgLAYIGMGVGnvIGLLSFSITSdkylqqKS 396
Cdd:cd17485  204 LRRPGTRWLLLFLLLYKLGE-QGALAMLPPFL--------VDRGFS-----LSQIGLLSG--VGGSLVSIAG------SL 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 397 AKGLQLKPEDRLPLMLLSGPAIAAGMFWYGWSAKAQTHWIVPILGSSLVGAGnmfFFMPMMgyLVDAYTI---YAASALA 473
Cdd:cd17485  262 LGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWVLLLASLALLH---LVGGMI--TTALFTLmmdCSQQAQA 336

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 242782825 474 AN--TVLRSIG--GGLL--PLAGqSMYKSLGYGWgnSLLGFIMIGFTPVVL 518
Cdd:cd17485  337 GTdyTLLATVEvlGKLLfgSLAG-FLADHLGYAA--AFLLFAILSALSVLL 384
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
331-519 9.55e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.42  E-value: 9.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 331 VLMSVSTAVVYGNLYLMLTTITAVFEvSYGWSTGISGLAYIGMGVGNVIGLLSFSITSDKYlqqksakglqlkpeDRLPL 410
Cdd:COG2814   13 LALALGAFLSGLGIGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF--------------GRRRV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242782825 411 MLLSGPAIAAGMFWYGWsakAQTHWIVpILGSSLVGAGNMFFFMPMMGYLVDAYTI-YAASALAANTVLRSIGGGLLPLA 489
Cdd:COG2814   78 LLLGLLLFALGSLLCAL---APSLWLL-LAARFLQGLGAGALFPAALALIADLVPPeRRGRALGLLGAGLGLGPALGPLL 153

                        170       180       190
                 ....*....|....*....|....*....|
gi 242782825 490 GQSMYKSLGYGWGNSLLGFIMIGFTPVVLF 519
Cdd:COG2814  154 GGLLADLFGWRWVFLVNAVLALLALLLLLR 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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