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Conserved domains on  [gi|242556686]
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Chain A, Pyrophosphate-dependent phosphofructokinase

Protein Classification

6-phosphofructokinase( domain architecture ID 10014575)

6-phosphofructokinase (diphosphate) catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis by using inorganic phosphate (PPi) as phosphoryl donor instead of ATP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
1-417 0e+00

diphosphate--fructose-6-phosphate 1-phosphotransferase;


:

Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 781.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686   1 MAAKNAFYAQSGGVTAVINASAAGVIEAARKqSGKIGRIYAGRNGIIGALTEDLIDTGQESDAAISALRYTPSGAFGSCR 80
Cdd:PRK14072   1 MMKGNALYAQSGGPTAVINASAAGVIEEARK-HKKIGKVYGARNGIIGILDEDLIDLSKESDEALAALAHTPSGALGSCR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  81 YKLKSLEQNRREYERLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLSGTLGYPIQAIHVPKTVDNDLPITDCCPGFGSVA 160
Cdd:PRK14072  80 YKLKSLEEDRAEYERLLEVFKAHDIGYFFYNGGNDSMDTALKVSQLAKKMGYPIRCIGIPKTIDNDLPGTDHCPGFGSAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 161 KYIAVSTLEASFDVASMSATStKVFVLEVMGRHAGWIAAAGGLASSPEREIPVVILFPEISFDKQKFLAKVDSCVKKFGY 240
Cdd:PRK14072 160 KYIATSVLEAALDVAAMANTS-KVFILEVMGRHAGWLAAAAALAKQNPDDAPHLIYLPERPFDEEKFLADVRAIVKRYGY 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 241 CSVVVSEGVKGDDGKFLSDQGVR-DAFGHAQLGGVAPVVASMVKEGLGLKYHWGVADYLQRAARHIASKTDVEQAYAMGQ 319
Cdd:PRK14072 239 CVVVVSEGIRDADGKFIAEAGLAeDAFGHAQLGGVAPVLANLIKEKLGKKVHWAVLDYLQRAARHIASKTDVEEAYAVGK 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 320 AAVEFAVQGHNSVMPTIERISARPYQWKVGMAQLSQVANVEKMMPENFITEDGFGITDLCREYLAPLIEGEDYPPYKDGL 399
Cdd:PRK14072 319 AAVEYALAGKNGVMPAIRRTSDDPYKWKIGLVPLSKVANKEKKMPPEFINEDGNGITEAFRRYLRPLIQGEPYPPYKNGL 398

                        410
                 ....*....|....*...
gi 242556686 400 PDYVRLKNVAVPKKLSGF 417
Cdd:PRK14072 399 PDYVRLKNVLVPKKLPAF 416
 
Name Accession Description Interval E-value
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
1-417 0e+00

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 781.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686   1 MAAKNAFYAQSGGVTAVINASAAGVIEAARKqSGKIGRIYAGRNGIIGALTEDLIDTGQESDAAISALRYTPSGAFGSCR 80
Cdd:PRK14072   1 MMKGNALYAQSGGPTAVINASAAGVIEEARK-HKKIGKVYGARNGIIGILDEDLIDLSKESDEALAALAHTPSGALGSCR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  81 YKLKSLEQNRREYERLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLSGTLGYPIQAIHVPKTVDNDLPITDCCPGFGSVA 160
Cdd:PRK14072  80 YKLKSLEEDRAEYERLLEVFKAHDIGYFFYNGGNDSMDTALKVSQLAKKMGYPIRCIGIPKTIDNDLPGTDHCPGFGSAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 161 KYIAVSTLEASFDVASMSATStKVFVLEVMGRHAGWIAAAGGLASSPEREIPVVILFPEISFDKQKFLAKVDSCVKKFGY 240
Cdd:PRK14072 160 KYIATSVLEAALDVAAMANTS-KVFILEVMGRHAGWLAAAAALAKQNPDDAPHLIYLPERPFDEEKFLADVRAIVKRYGY 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 241 CSVVVSEGVKGDDGKFLSDQGVR-DAFGHAQLGGVAPVVASMVKEGLGLKYHWGVADYLQRAARHIASKTDVEQAYAMGQ 319
Cdd:PRK14072 239 CVVVVSEGIRDADGKFIAEAGLAeDAFGHAQLGGVAPVLANLIKEKLGKKVHWAVLDYLQRAARHIASKTDVEEAYAVGK 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 320 AAVEFAVQGHNSVMPTIERISARPYQWKVGMAQLSQVANVEKMMPENFITEDGFGITDLCREYLAPLIEGEDYPPYKDGL 399
Cdd:PRK14072 319 AAVEYALAGKNGVMPAIRRTSDDPYKWKIGLVPLSKVANKEKKMPPEFINEDGNGITEAFRRYLRPLIQGEPYPPYKNGL 398

                        410
                 ....*....|....*...
gi 242556686 400 PDYVRLKNVAVPKKLSGF 417
Cdd:PRK14072 399 PDYVRLKNVLVPKKLPAF 416
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 4-366 6.90e-120

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 352.07  E-value: 6.90e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686   4 KNAFYAQSGGVTAVINASAAGVIEAARKQsgKIgRIYAGRNGIIGALTEDLIDTGQESdaaISALRYTPSGAFGSCRYKL 83
Cdd:COG0205    2 KRIGILTSGGDAPGLNAAIRAVVRTAIKY--GI-EVYGIRDGYEGLLEGDIIDLTRED---VSGILQRGGTILGSSRSKP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  84 KsleQNRREYERLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLsgtlgYPIQAIHVPKTVDNDLPITDCCPGFGSVAKYI 163
Cdd:COG0205   76 F---KTEEGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEE-----YGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTA 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 164 AVSTLEASFDVASmsatSTKVFVLEVMGRHAGWIAAAGGLASSPEreipvVILFPEISFDKQKFLAKVDSCVKKF-GYCS 242
Cdd:COG0205  148 AEAIDRLRDTAAS----HERVFVVEVMGRHAGWLALAAGLAGGAD-----LILIPEVPFDLDKLLEKLKERRKRGkGYSI 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 243 VVVSEGVKGDDGKFLSDQGvRDAFGHAQLGGVAPVVASMVKEGLGLKYHWGVADYLQRAARhiASKTDVEQAYAMGQAAV 322
Cdd:COG0205  219 IVVAEGAGDEDGEAVLEAD-TDAFGHVRLGGIGEYLAKEIEERTGIETRVTVLGHLQRGGS--PSAFDRVLASRLGAAAV 295

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 242556686 323 EFAVQGHNSVMPTIER--ISARPyqwkvgmaqLSQVANVEKMMPEN 366
Cdd:COG0205  296 ELLLEGKTGVMVGIRRgeIVLVP---------LEEVANKEKPVDPD 332
PFK pfam00365
Phosphofructokinase;
10-273 9.41e-52

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 174.84  E-value: 9.41e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686   10 QSGGVTAVINASAAGVIEAARKQsgkiG-RIYAGRNGIIGALTEDLIDTGQESdaaISALRYTPSGAFGSCRYKLkslEQ 88
Cdd:pfam00365   6 TSGGDAPGMNAAIRAVVRTAIYR----GhEVYGIRNGYEGLVEGDIDELTWRD---VSGILNRGGTILGTSRSKP---FK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686   89 NRREYERLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLSGtlgypIQAIHVPKTVDNDLPITDCCPGFGSVAKYIAvstl 168
Cdd:pfam00365  76 TEEGREKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG-----IPVVGIPKTIDNDIPGTDYTIGFDTALNTIV---- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  169 EASfDVASMSATSTK-VFVLEVMGRHAGWIAAAGGLASSPEreipvVILFPEISFDKQKFLAKVDSCVKKFGYCSVVVSE 247
Cdd:pfam00365 147 EAI-DRIRDTASSHNrVFVVEVMGRHCGWLALMAGLAGGAD-----AILIPEIPFDIEELCEKIKELRKGKRFSIIVVAE 220

                         250       260       270
                  ....*....|....*....|....*....|....
gi 242556686  248 GVKgdDGKFLSDQG-------VR-DAFGHAQLGG 273
Cdd:pfam00365 221 GAS--DGEFLAKLIeegtgieTRvTVLGHVQRGG 252
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
 113-333 1.01e-28

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 114.71  E-value: 1.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  113 GGDsaDTcLKVSQLSGTLGYPIqaIHVPKTVDNDLPITDCCPGFGSvakyiAVSTLEASFDVASMSATS-TKVFVLEVMG 191
Cdd:TIGR02483 102 GGD--GT-LGIARRLADKGLPV--VGVPKTIDNDLEATDYTFGFDT-----AVEIATEALDRLHTTAEShHRVMVVEVMG 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  192 RHAGWIAAAGGLASSPEreipvVILFPEISFDKQKFLAKVDSCVKKFG-YCSVVVSEGVKGDDGKFLSDQGVRDAFGHAQ 270
Cdd:TIGR02483 172 RHAGWIALHSGIAGGAD-----VILIPEIPFDIDSVCEKVRERFARGKrFAIVVVAEGAKPKGGEMVVQEGVKDAFGHVR 246

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242556686  271 LGGVAPVVASMVKEGLGLKYHWGVADYLQRAArhIASKTDVEQAYAMGQAAVEFAVQGHNSVM 333
Cdd:TIGR02483 247 LGGIGNWLAEEIERRTGIETRATVLGHLQRGG--SPSAFDRVLATRFGVAAVDLVHEGQFGHM 307
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 11-361 5.45e-20

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 90.44  E-value: 5.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  11 SGGVTAVINASAAGVIEAARKQSGKIGRIYAGRNGIIGAlteDLIDTGQESdaaISALRYTPSGAFGSCRYKLKSLEQNR 90
Cdd:cd00363    8 SGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG---DIKELDWES---VSDIINRGGTIIGSARCKEFRTEEGR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  91 ReyeRLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLSGTLGYPIQAIHVPKTVDNDLPITDCCPGFGSvakyiAVSTLEA 170
Cdd:cd00363   82 A---KAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSKYQGFNVIGLPGTIDNDIKGTDYTIGFDT-----ALKTIVE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 171 SFDVASMSATSTK-VFVLEVMGRHAGWIAAAGGLASSPEreipvVILFPEISFDKQKFLAKVDSCV------KKFGYcsV 243
Cdd:cd00363  154 AIDRIRDTASSHQrTFVVEVMGRHCGDIALEAGLATGAD-----IIFIPEEPAADEWEEEMVDVIKkrrergKRHGI--V 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 244 VVSEGVKGDDGKFLSDQGvrdafghaqlggvapvVASMVKEGLGLKYHWGVADYLQRAArhIASKTDVEQAYAMGQAAVE 323
Cdd:cd00363  227 IVAEGAIDFIPKPITEKL----------------LAKLVEERLGFDTRATVLGHVQRGG--TPTAFDRILASRLGAEAVE 288

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 242556686 324 FAVQGHNSVMPTIERISarpyQWKVGMAQLSQVANVEK 361
Cdd:cd00363  289 LLLEGTGGTPVGIQNLN----ENQVVRHPLTEAVNMTK 322
PFKA_PPi_Ttgales NF041103
diphosphate--fructose-6-phosphate 1-phosphotransferase;
94-343 5.61e-13

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 469029  Cd Length: 406  Bit Score: 69.89  E-value: 5.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  94 ERLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLSGtlgYPIQAIHVPKTVDNDLPITDCCPGFG-SVAKYIAVSTLEASF 172
Cdd:NF041103  83 ENVVDTLKELGVTHLVTIGGDDTAFSASKVAKYAG---GRIRVVHVPKTIDNDLPLPEGIPTFGfETARHVGVELVKNLM 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 173 DVASmsaTSTKVFVLEVMGRHAGWIAAAGGLASSpereiPVVILFPEiSFDKQKF-LAKV-D----SCVKKF----GYCS 242
Cdd:NF041103 160 EDAR---TTNRWYFVVAMGRKAGHLALGIGKAAG-----ATLTIIPE-EFREEKItLQTVvDilvgSIIKRLamgrNYGV 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 243 VVVSEGV--KGDDGKFLSDQGV-RDAFGHAQLGGV--APVVASMVKEGL---GLKYHWGVAD--YLQRAARHIAskTDVE 312
Cdd:NF041103 231 AVLAEGLieKIDPEDLEALGGVeRDEHGHIRLAEInfGEILKKAVKKRLkelGIKITIVDKNigYELRCADPIP--FDIE 308

                        250       260       270
                 ....*....|....*....|....*....|.
gi 242556686 313 QAYAMGQAAVEFAVQGHNSVMPTIERISARP 343
Cdd:NF041103 309 YTRDLGYGAVRFLLEGGTGAMISIQNGRFVP 339
 
Name Accession Description Interval E-value
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
1-417 0e+00

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 781.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686   1 MAAKNAFYAQSGGVTAVINASAAGVIEAARKqSGKIGRIYAGRNGIIGALTEDLIDTGQESDAAISALRYTPSGAFGSCR 80
Cdd:PRK14072   1 MMKGNALYAQSGGPTAVINASAAGVIEEARK-HKKIGKVYGARNGIIGILDEDLIDLSKESDEALAALAHTPSGALGSCR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  81 YKLKSLEQNRREYERLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLSGTLGYPIQAIHVPKTVDNDLPITDCCPGFGSVA 160
Cdd:PRK14072  80 YKLKSLEEDRAEYERLLEVFKAHDIGYFFYNGGNDSMDTALKVSQLAKKMGYPIRCIGIPKTIDNDLPGTDHCPGFGSAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 161 KYIAVSTLEASFDVASMSATStKVFVLEVMGRHAGWIAAAGGLASSPEREIPVVILFPEISFDKQKFLAKVDSCVKKFGY 240
Cdd:PRK14072 160 KYIATSVLEAALDVAAMANTS-KVFILEVMGRHAGWLAAAAALAKQNPDDAPHLIYLPERPFDEEKFLADVRAIVKRYGY 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 241 CSVVVSEGVKGDDGKFLSDQGVR-DAFGHAQLGGVAPVVASMVKEGLGLKYHWGVADYLQRAARHIASKTDVEQAYAMGQ 319
Cdd:PRK14072 239 CVVVVSEGIRDADGKFIAEAGLAeDAFGHAQLGGVAPVLANLIKEKLGKKVHWAVLDYLQRAARHIASKTDVEEAYAVGK 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 320 AAVEFAVQGHNSVMPTIERISARPYQWKVGMAQLSQVANVEKMMPENFITEDGFGITDLCREYLAPLIEGEDYPPYKDGL 399
Cdd:PRK14072 319 AAVEYALAGKNGVMPAIRRTSDDPYKWKIGLVPLSKVANKEKKMPPEFINEDGNGITEAFRRYLRPLIQGEPYPPYKNGL 398

                        410
                 ....*....|....*...
gi 242556686 400 PDYVRLKNVAVPKKLSGF 417
Cdd:PRK14072 399 PDYVRLKNVLVPKKLPAF 416
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 4-366 6.90e-120

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 352.07  E-value: 6.90e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686   4 KNAFYAQSGGVTAVINASAAGVIEAARKQsgKIgRIYAGRNGIIGALTEDLIDTGQESdaaISALRYTPSGAFGSCRYKL 83
Cdd:COG0205    2 KRIGILTSGGDAPGLNAAIRAVVRTAIKY--GI-EVYGIRDGYEGLLEGDIIDLTRED---VSGILQRGGTILGSSRSKP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  84 KsleQNRREYERLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLsgtlgYPIQAIHVPKTVDNDLPITDCCPGFGSVAKYI 163
Cdd:COG0205   76 F---KTEEGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEE-----YGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTA 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 164 AVSTLEASFDVASmsatSTKVFVLEVMGRHAGWIAAAGGLASSPEreipvVILFPEISFDKQKFLAKVDSCVKKF-GYCS 242
Cdd:COG0205  148 AEAIDRLRDTAAS----HERVFVVEVMGRHAGWLALAAGLAGGAD-----LILIPEVPFDLDKLLEKLKERRKRGkGYSI 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 243 VVVSEGVKGDDGKFLSDQGvRDAFGHAQLGGVAPVVASMVKEGLGLKYHWGVADYLQRAARhiASKTDVEQAYAMGQAAV 322
Cdd:COG0205  219 IVVAEGAGDEDGEAVLEAD-TDAFGHVRLGGIGEYLAKEIEERTGIETRVTVLGHLQRGGS--PSAFDRVLASRLGAAAV 295

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 242556686 323 EFAVQGHNSVMPTIER--ISARPyqwkvgmaqLSQVANVEKMMPEN 366
Cdd:COG0205  296 ELLLEGKTGVMVGIRRgeIVLVP---------LEEVANKEKPVDPD 332
PFK pfam00365
Phosphofructokinase;
10-273 9.41e-52

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 174.84  E-value: 9.41e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686   10 QSGGVTAVINASAAGVIEAARKQsgkiG-RIYAGRNGIIGALTEDLIDTGQESdaaISALRYTPSGAFGSCRYKLkslEQ 88
Cdd:pfam00365   6 TSGGDAPGMNAAIRAVVRTAIYR----GhEVYGIRNGYEGLVEGDIDELTWRD---VSGILNRGGTILGTSRSKP---FK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686   89 NRREYERLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLSGtlgypIQAIHVPKTVDNDLPITDCCPGFGSVAKYIAvstl 168
Cdd:pfam00365  76 TEEGREKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG-----IPVVGIPKTIDNDIPGTDYTIGFDTALNTIV---- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  169 EASfDVASMSATSTK-VFVLEVMGRHAGWIAAAGGLASSPEreipvVILFPEISFDKQKFLAKVDSCVKKFGYCSVVVSE 247
Cdd:pfam00365 147 EAI-DRIRDTASSHNrVFVVEVMGRHCGWLALMAGLAGGAD-----AILIPEIPFDIEELCEKIKELRKGKRFSIIVVAE 220

                         250       260       270
                  ....*....|....*....|....*....|....
gi 242556686  248 GVKgdDGKFLSDQG-------VR-DAFGHAQLGG 273
Cdd:pfam00365 221 GAS--DGEFLAKLIeegtgieTRvTVLGHVQRGG 252
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
 113-333 1.01e-28

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 114.71  E-value: 1.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  113 GGDsaDTcLKVSQLSGTLGYPIqaIHVPKTVDNDLPITDCCPGFGSvakyiAVSTLEASFDVASMSATS-TKVFVLEVMG 191
Cdd:TIGR02483 102 GGD--GT-LGIARRLADKGLPV--VGVPKTIDNDLEATDYTFGFDT-----AVEIATEALDRLHTTAEShHRVMVVEVMG 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  192 RHAGWIAAAGGLASSPEreipvVILFPEISFDKQKFLAKVDSCVKKFG-YCSVVVSEGVKGDDGKFLSDQGVRDAFGHAQ 270
Cdd:TIGR02483 172 RHAGWIALHSGIAGGAD-----VILIPEIPFDIDSVCEKVRERFARGKrFAIVVVAEGAKPKGGEMVVQEGVKDAFGHVR 246

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242556686  271 LGGVAPVVASMVKEGLGLKYHWGVADYLQRAArhIASKTDVEQAYAMGQAAVEFAVQGHNSVM 333
Cdd:TIGR02483 247 LGGIGNWLAEEIERRTGIETRATVLGHLQRGG--SPSAFDRVLATRFGVAAVDLVHEGQFGHM 307
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
113-328 1.50e-22

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 97.83  E-value: 1.50e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 113 GGDSADTCL-KVSQLSGtlgypIQAIHVPKTVDNDLPITDCCPGFgSVAKYIAVSTLEA-SFDVASMSatstKVFVLEVM 190
Cdd:PRK14071 115 GGDGSLAILrRLAQQGG-----INLVGIPKTIDNDVGATEVSIGF-DTAVNIATEALDRlHFTAASHN----RVMILEVM 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 191 GRHAGWIAAAGGLASSPEreipvVILFPEISFDKQKFLAKVDScVKKFG--YCSVVVSEGVKGDDGKFLSdqgVRDAFGH 268
Cdd:PRK14071 185 GRDAGHIALAAGIAGGAD-----VILIPEIPYTLENVCKKIRE-RQEEGknFCLVVVSEAVRTEEGEQVT---KTQALGE 255

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 269 AQLGGVAPVVASMVKEGLGLKYHWGVADYLQRAArhIASKTDVEQAYAMGQAAVEFAVQG 328
Cdd:PRK14071 256 DRYGGIGQYLAEQIAERTGAETRVTVLGHIQRGG--IPSPRDRLLASAFGVAAVDLIAQG 313
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
94-333 7.29e-22

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 95.15  E-value: 7.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  94 ERLIEVFKAHDIGYFFYNGGGDSadtcLKVSQLSGTLGYPIqaIHVPKTVDNDLPITDCCPGFGSvakyiAVST-LEASF 172
Cdd:PRK03202  83 AKAIENLKKLGIDALVVIGGDGS----YMGAKRLTEHGIPV--IGLPGTIDNDIAGTDYTIGFDT-----ALNTaVEAID 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 173 DVASMSATSTKVFVLEVMGRHAGWIAAAGGLASSPEreipvVILFPEISFDKQKFLAKVDScVKKFG--YCSVVVSEGVK 250
Cdd:PRK03202 152 RLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAE-----VILIPEVPFDIEELCAKIKK-GRERGkkHAIIVVAEGVM 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 251 GDDG--KFLSDQGVRDA----FGHAQLGGvAPVVASMVkeglglkyhwgvadylqraarhIASKtdveqayaMGQAAVEF 324
Cdd:PRK03202 226 PAEElaKEIEERTGLETrvtvLGHIQRGG-SPTAFDRV----------------------LASR--------MGAHAVEL 274


                 ....*....
gi 242556686 325 AVQGHNSVM 333
Cdd:PRK03202 275 LLEGKGGRM 283
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 11-361 5.45e-20

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 90.44  E-value: 5.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  11 SGGVTAVINASAAGVIEAARKQSGKIGRIYAGRNGIIGAlteDLIDTGQESdaaISALRYTPSGAFGSCRYKLKSLEQNR 90
Cdd:cd00363    8 SGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG---DIKELDWES---VSDIINRGGTIIGSARCKEFRTEEGR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  91 ReyeRLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLSGTLGYPIQAIHVPKTVDNDLPITDCCPGFGSvakyiAVSTLEA 170
Cdd:cd00363   82 A---KAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSKYQGFNVIGLPGTIDNDIKGTDYTIGFDT-----ALKTIVE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 171 SFDVASMSATSTK-VFVLEVMGRHAGWIAAAGGLASSPEreipvVILFPEISFDKQKFLAKVDSCV------KKFGYcsV 243
Cdd:cd00363  154 AIDRIRDTASSHQrTFVVEVMGRHCGDIALEAGLATGAD-----IIFIPEEPAADEWEEEMVDVIKkrrergKRHGI--V 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 244 VVSEGVKGDDGKFLSDQGvrdafghaqlggvapvVASMVKEGLGLKYHWGVADYLQRAArhIASKTDVEQAYAMGQAAVE 323
Cdd:cd00363  227 IVAEGAIDFIPKPITEKL----------------LAKLVEERLGFDTRATVLGHVQRGG--TPTAFDRILASRLGAEAVE 288

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 242556686 324 FAVQGHNSVMPTIERISarpyQWKVGMAQLSQVANVEK 361
Cdd:cd00363  289 LLLEGTGGTPVGIQNLN----ENQVVRHPLTEAVNMTK 322
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 38-343 1.82e-17

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 83.94  E-value: 1.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  38 RIYAGRNGIIGALTEDLIDTGQESDAAISALrytpSGAF-GSCRYKlksleQNRREyerLIEVFKAHDIGYFFYNGGGDS 116
Cdd:PTZ00286 121 TIYGAKYGYKGLYKEDWIKLDPKDVKTIHRL----GGTIlGSSRGG-----FDPKV---MVDTLIRHGINILFTLGGDGT 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 117 ADTCLKVSQLSGTLGYPIQAIHVPKTVDNDLPITDCCPGFGSvAKYIAVSTLEASFdVASMSAtSTKVFVLEVMGRHAGW 196
Cdd:PTZ00286 189 HRGALAIYKELRRRKLNISVVGIPKTIDNDIPIIDESFGFQT-AVEEAQNAIRAAY-VEAKSA-KNGVGIVKLMGRDSGF 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 197 IAAAGGLASspeREIPVViLFPEISFDKQKFLAKVDSCVKKFGYCSVVVSEGVkGDDGKFLSDQGVRDAFGHAQLGGVAP 276
Cdd:PTZ00286 266 IALHASVAS---ADVNVC-LIPEFDIPLEGVLEYIEQRLQKKGHCVIVVAEGA-GQSLKDADLDLGTDASGNKKLWDIGV 340

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 277 VVASMVKEGLG-------LKYhwgvAD--YLQRAARhiASKTDVEQAYAMGQAAVEFAVQG----------HNSVMPTIE 337
Cdd:PTZ00286 341 YLKDEITKYLKkkkpehtVKY----IDpsYMIRAVP--ANAADAKFCTQLAQNAVHGAMAGftgfiighvhNNYVMIPIK 414


                 ....*.
gi 242556686 338 RISARP 343
Cdd:PTZ00286 415 EMSGNY 420
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
 11-343 2.16e-16

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 79.31  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686   11 SGGVTAVINASAAGVIEAARKQSGKIGRIYAGRNGIIGALTEDLidtgqesdAAISALRYTPSG--AFGSCRYK-LKSLE 87
Cdd:TIGR02482   7 SGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLINGKIEPL--------ESKNVSGIIHRGgtILGTARCPeFKTEE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686   88 QNRREYERLievfKAHDIGYFFYNGGGDSADTCLKVSQLSGtlgypIQAIHVPKTVDNDLPITDCCPGFGSvakyiAVST 167
Cdd:TIGR02482  79 VREKAVENL----KKLGIEGLVVIGGDGSYTGAQKLYEEGG-----IPVIGLPGTIDNDIPGTDYTIGFDT-----ALNT 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  168 LEASFDVASMSATS-TKVFVLEVMGRHAGWIAAAGGLASSPEreipvVILFPEISFDKQKFLAKVDSCVKKFGYCSVV-V 245
Cdd:TIGR02482 145 IIDAVDKIRDTATShERAFVIEVMGRHAGDLALYAGIATGAE-----IIIIPEFDYDIDELIQRLKEQHEAGKKHSIIiV 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  246 SEGVKGDDGKflsdqgvrdafghaqlggvapVVASMVKEGLGLKYHWGVADYLQRAARhiASKTDVEQAYAMGQAAVEFA 325
Cdd:TIGR02482 220 AEGNIVGSAK---------------------EVAKKIEEKTGIETRVTVLGHTQRGGS--PSAFDRVLASRLGAKAVELL 276

                         330       340
                  ....*....|....*....|
gi 242556686  326 VQGHNSVMPTIE--RISARP 343
Cdd:TIGR02482 277 LEGKGGVMIGIQnnKIVTHP 296
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 11-337 3.87e-16

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 78.61  E-value: 3.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  11 SGGVTAVINASAAGVIEAARKQSGKIGRIYAGRNGIIgaltEDLIDTGQESDAAISALRytpSGAF-GSCRYKLKSLEQN 89
Cdd:cd00763    8 SGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLI----AGDIVPLDRYSVSDIINR---GGTFlGSARFPEFKDEEG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  90 RReyeRLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLsgtlGYPiqAIHVPKTVDNDLPITDCCPGFGSvakyiAVST-L 168
Cdd:cd00763   81 QA---KAIEQLKKHGIDALVVIGGDGSYMGAMRLTEH----GFP--CVGLPGTIDNDIPGTDYTIGFDT-----ALNTvV 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 169 EASFDVASMSATSTKVFVLEVMGRHAGWIAAAGGLASSPEreipvVILFPEISFDKQKFLAKVDSCVKKFGYCS-VVVSE 247
Cdd:cd00763  147 EAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAE-----FIVIPEAEFDREEVANRIKAGIERGKKHAiVVVAE 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 248 GVKGDDG--KFLSDQGVRDA----FGHAQLGGvAPVVASmvkeglglkyhwgvadylqraaRHIASKtdveqayaMGQAA 321
Cdd:cd00763  222 GVYDVDElaKEIEEATGFETratvLGHIQRGG-SPTAFD----------------------RILASR--------MGAYA 270

                        330
                 ....*....|....*.
gi 242556686 322 VEFAVQGHNSVMPTIE 337
Cdd:cd00763  271 VELLLAGKGGLAVGIQ 286
PFKA_PPi_Ttgales NF041103
diphosphate--fructose-6-phosphate 1-phosphotransferase;
94-343 5.61e-13

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 469029  Cd Length: 406  Bit Score: 69.89  E-value: 5.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  94 ERLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLSGtlgYPIQAIHVPKTVDNDLPITDCCPGFG-SVAKYIAVSTLEASF 172
Cdd:NF041103  83 ENVVDTLKELGVTHLVTIGGDDTAFSASKVAKYAG---GRIRVVHVPKTIDNDLPLPEGIPTFGfETARHVGVELVKNLM 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 173 DVASmsaTSTKVFVLEVMGRHAGWIAAAGGLASSpereiPVVILFPEiSFDKQKF-LAKV-D----SCVKKF----GYCS 242
Cdd:NF041103 160 EDAR---TTNRWYFVVAMGRKAGHLALGIGKAAG-----ATLTIIPE-EFREEKItLQTVvDilvgSIIKRLamgrNYGV 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 243 VVVSEGV--KGDDGKFLSDQGV-RDAFGHAQLGGV--APVVASMVKEGL---GLKYHWGVAD--YLQRAARHIAskTDVE 312
Cdd:NF041103 231 AVLAEGLieKIDPEDLEALGGVeRDEHGHIRLAEInfGEILKKAVKKRLkelGIKITIVDKNigYELRCADPIP--FDIE 308

                        250       260       270
                 ....*....|....*....|....*....|.
gi 242556686 313 QAYAMGQAAVEFAVQGHNSVMPTIERISARP 343
Cdd:NF041103 309 YTRDLGYGAVRFLLEGGTGAMISIQNGRFVP 339
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
131-284 2.66e-12

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 67.97  E-value: 2.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 131 GYPIQAIHVPKTVDNDLPITDCCPGFGSvakyiAVSTLEASFDVASMSATSTK--VFVLEVMGRHAGWIAAAGGLASSpe 208
Cdd:PRK06830 199 GLKISVIGIPKTIDNDINFIQKSFGFET-----AVEKATEAIRCAHVEANGAPngIGLVKLMGRHSGFIAAYAALASK-- 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 209 rEIPVViLFPEISFD---KQKFLAKVDSCVKKFGYCSVVVSEGVkgddG-KFLSDQGVRDAFGHAQLGGVAPVVASMVKE 284
Cdd:PRK06830 272 -DVNFV-LIPEVPFDlegPNGLLAALEKRLAERGHAVIVVAEGA----GqELFDDTGETDASGNPKLGDIGLFLKDRIKE 345
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
 1-332 4.16e-12

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 67.34  E-value: 4.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686   1 MAAKNAFYAQSGGVTAVINASAAGVIEAARKQSGKIgRIYAGRNGIIGALTEDLIDTGQESDAAISAL-RYTPSgAFGSC 79
Cdd:PRK06555   1 MAVKKVALLTAGGLAPCLSSAVGGLIERYTEIAPEV-EIIAYRSGYQGLLLGDSIEITPAVRANAGLLhRYGGS-PIGNS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  80 RYKLKSLE-----------QN--RREYERLIE--VFKAHDIGyffynggGDsaDTCLKVSQLSGTL---GYPIQAIHVPK 141
Cdd:PRK06555  79 RVKLTNVAdcvkrglvkegENplKVAAERLAAdgVDILHTIG-------GD--DTNTTAADLAAYLaenGYDLTVVGLPK 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 142 TVDNDL-PITDccpgfgSVAKYIAVSTLEASFD--VASMSATSTKVFVLEVMGRHAGWIAAA---------------GGL 203
Cdd:PRK06555 150 TIDNDVvPIRQ------SLGAWTAAEQGARFFDnvINEHSANPRMLIIHEVMGRNCGWLTAAtarayrewldrqeyvPGF 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 204 ASSPER-EIPVVILfPEISFDKQKFLAKVDSCVKKFGYCSVVVSEGVKGDD--GKFLSD-QGV-RDAFGHAQLGGVAP-- 276
Cdd:PRK06555 224 GLSAERwDIHAVYL-PEMAFDLEAEAERLKAVMDEVGNVNIFLSEGAGLDAivAEMEAAgEEVkRDAFGHVKLDTINPga 302

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 242556686 277 -----------VVASMV-KEGlglkyhwgvadYLQRAARhiASKTDVEQAYAMGQAAVEFAVQGHNSV 332
Cdd:PRK06555 303 wfakqfaellgAEKVMVqKSG-----------YFARSAP--ANAEDLRLIKSMVDLAVECALRGVSGV 357
PLN02884 PLN02884
6-phosphofructokinase
 139-341 3.92e-09

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 58.28  E-value: 3.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 139 VPKTVDNDLPITDCCPGFGSvakyiAVSTLEASFDVASMSATST--KVFVLEVMGRHAGWIAAAGGLASSperEIPVViL 216
Cdd:PLN02884 178 VPKTIDNDILLMDKTFGFDT-----AVEEAQRAINSAYIEAHSAyhGIGLVKLMGRSSGFIAMHASLASG---QVDIC-L 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 217 FPEISFD---KQKFLAKVDSCVKKFGYCSVVVSEGVKGDdgkFLSDQGVRDAFGHAQLGGVAPVVASMVKE-----GLGL 288
Cdd:PLN02884 249 IPEVPFTldgPNGVLRHLEHLIETKGSAVVCVAEGAGQD---LLQKTNATDASGNPVLGDIGVHLQQEIKKhfkdiGVPA 325

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242556686 289 KYHWGVADYLQRAARhiASKTDVEQAYAMGQAAVEFAVQG-----------HNSVMPTIERISA 341
Cdd:PLN02884 326 DVKYIDPTYMIRACR--ANASDAILCTVLGQNAVHGAFAGfsgitvgicntHYVYLPIPEVIAY 387
PLN02564 PLN02564
6-phosphofructokinase
 139-330 6.63e-08

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 54.37  E-value: 6.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 139 VPKTVDNDLPITDCCPGFGSvakyiAVSTLEASFDVASMSATSTK--VFVLEVMGRHAGWIAAAGGLASspeREIPVViL 216
Cdd:PLN02564 211 IPKTIDNDIPVIDKSFGFDT-----AVEEAQRAINAAHVEAESVEngIGLVKLMGRYSGFIAMYATLAS---RDVDCC-L 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 217 FPEISF---DKQKFLAKVDSCVKKFGYCSVVVSEGVkGDD--GKFLSDQGVRDAFGHAQLGGVAPVVASMVKE------- 284
Cdd:PLN02564 282 IPESPFyleGKGGLFEFIEKRLKENGHMVIVVAEGA-GQDliAESMESSDLQDASGNKLLLDVGLWLSQKIKDhftkvkk 360

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 242556686 285 -GLGLKYhwgvAD--YLQRAARHIASktdvEQAYA--MGQAAVEFAVQGHN 330
Cdd:PLN02564 361 mPINLKY----IDptYMIRAIPSNAS----DNVYCtlLAHSAVHGAMAGYT 403
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 142-277 6.63e-08

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 54.65  E-value: 6.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  142 TVDNDLPITDCCPGFGSVAKYIavstLEASFDVASMSATSTKVFVLEVMGRHAGWIAAAGGLASSPEreipvVILFPEIS 221
Cdd:TIGR02478 149 SIDNDMCGTDMTIGADSALHRI----CEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGAD-----YVFIPERP 219

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242556686  222 FDK--QKFLAKVDSCVKKFG--YCSVVVSEGVKGDDGKFLSDQGVRD-------------AFGHAQLGGvAPV 277
Cdd:TIGR02478 220 PEEgwEDQLCHKLKRNRKAGkrKTIVIVAEGAIDRDLNPITSEDVKDvlverlgldtritVLGHVQRGG-APS 291
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 142-275 1.73e-07

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 53.29  E-value: 1.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 142 TVDNDLPITDCcpgfgSVAKYIAVSTLEASFDVASMSATS-TKVFVLEVMGRHAGWIAAAGGLASSPEreipvVILFPEI 220
Cdd:cd00764  152 SIDNDFCGTDM-----TIGTDSALHRICEVVDAITTTAQShQRTFVLEVMGRHCGYLALVSGLATGAD-----WIFIPER 221

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242556686 221 SFDK--QKFLAKVDSCVKKFG--YCSVVVSEGVKGDDGKFLSDQGVRD-------------AFGHAQLGGVA 275
Cdd:cd00764  222 PPEDgwEDQMCRRLSEHRSRGkrLNIIIVAEGAIDDQLKPITSEDVKDlvverlgldtrvtTLGHVQRGGTP 293
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 16-274 3.89e-07

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 52.52  E-value: 3.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  16 AVINASA-AGVIEAARKQSGKIG-----RIYAGRNGIIGaltedLIDTGQESDAAISALRYTPSGafGSCRYKLKSLEQn 89
Cdd:cd00764  393 AIVNVGApAAGMNAAVRSAVRYGlahghRPYAIYDGFEG-----LAKGQIVELGWIDVGGWTGRG--GSELGTKRTLPK- 464

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  90 rREYERLIEVFKAHDIGYFFYNGGGDSADTCLKVSQlsGTLGYPIQAIH---VPKTVDNDLPITDCcpgfgSVAKYIAVS 166
Cdd:cd00764  465 -KDLETIAYNFQKYGIDGLIIVGGFEAYKGLLQLRE--AREQYEEFCIPmvlIPATVSNNVPGTDF-----SLGSDTALN 536

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 167 TLEASFDVASMSATSTK--VFVLEVMGRHAGWIAAAGGLASS------PEREIPVVILFPEISFDKQKF-----LAKVDS 233
Cdd:cd00764  537 ALMKYCDRIKQSASGTKrrVFIVETMGGYCGYLATMTGLAVGadaayvFEEPFNIRDLQENVEHLTEKMkttigRGLVLR 616

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 242556686 234 CVKKFGYCSVVVSEGVKGDDGKFLSDqgVRDAF-GHAQLGGV 274
Cdd:cd00764  617 NEKCNENYTTVFTYELYSEEGKGVFD--CRTNVlGHVQQGGA 656
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 113-227 2.38e-06

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 49.65  E-value: 2.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  113 GGDSADTCLkvSQL-SGTLGYP---IQAIHVPKTVDNDLPITDCcpgfgSVAKYIAVSTLEASFDVASMSATSTK--VFV 186
Cdd:TIGR02478 486 GGFEAFEAL--YQLdAAREKYPafrIPMVVIPATISNNVPGTEY-----SLGSDTALNEITEYCDNIKQSASASKrrVFV 558

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 242556686  187 LEVMGRHAGWIAAAGGLASS------PEREIPVVILFPEISFDKQKF 227
Cdd:TIGR02478 559 VETMGGYSGYLATMAGLATGadaayiPEEGISLKDLQEDIEHLKETF 605
Pyrophosphate_PFK cd00765
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 23-361 2.90e-04

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.


Pssm-ID: 238390  Cd Length: 550  Bit Score: 42.94  E-value: 2.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  23 AGVIEAARKQSgKIGRIYAGRNGIIGALTEDLIDTGQEsdaAISALRYTpsGAF---GSCRYKLKSLEQnrreYERLIEV 99
Cdd:cd00765   92 SGLFDYLKERA-KGSTLYGFKGGPAGILKCDYIELNAE---YIQPYRNT--GGFdmiCSGRTKIETEDQ----FKQAEET 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 100 FKAHDIGYFFYNGGGDSADTCLKVSQLSGTLGYPIQAIHVPKTVDNDLPITDCCPGFGSVAKYIAVSTLEASFDVASMSA 179
Cdd:cd00765  162 AKKLDLDALVVIGGDDSNTNAALLAENFRSKGLKTRVIGVPKTIDGDLKNKEIETSFGFDTATKIYSELIGNVMRDARST 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 180 TSTKVFVlEVMGRHAGWIAAAGGLASSPEreipVVILFPEISFDKQKFLAKVDSCVK--------KFGYCSVVVSEGV-- 249
Cdd:cd00765  242 GKYWHFV-KLMGRSASHIALECALKTHPN----ICIISEEVSAQKQTLKNITDYMVDvickraelGYNFGVVLVPEGLie 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 250 -----------------------KGDDGKFLSDQGV--------------------------RDAFGHAQLGG------- 273
Cdd:cd00765  317 fipevkeliaelneilanevvefNGLWKKKLTEQSLklfdllpkgvylplfieaiqeqlmleRDPHGNVQVSRietekll 396

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686 274 ---VAPVVASMVKEGLGLKYHWGVADYLQRAAR-HIASKTDVEQAYAMGQAAVEFAVQGHNSVMPTIERISARPYQWKVG 349
Cdd:cd00765  397 iqmVETRLEKMKQAGAYKGQFMGQSHFFGYEGRcAFPSNFDADYCYALGYGAGVLLNSGKTGYISSVGNLAAPVEEWTVG 476

                        410
                 ....*....|..
gi 242556686 350 MAQLSQVANVEK 361
Cdd:cd00765  477 GVPLTMLMNMER 488
PRK07085 PRK07085
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
 50-147 3.64e-04

diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 235930  Cd Length: 555  Bit Score: 42.60  E-value: 3.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242556686  50 LTEDLIDTgqesdaaisalrYTPSGAF---GSCRYKLKSLEQnrreYERLIEVFKAHDIGYFFYNGGGDS-ADTCLKVSQ 125
Cdd:PRK07085 123 ITEEVIDE------------YRNTGGFdmiGSGRTKIETEEQ----KEACLETVKKLKLDGLVIIGGDDSnTNAAILAEY 186

                         90       100
                 ....*....|....*....|..
gi 242556686 126 LSGTlGYPIQAIHVPKTVDNDL 147
Cdd:PRK07085 187 FAKH-GCKTQVIGVPKTIDGDL 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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