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Conserved domains on  [gi|242247521|ref|NP_001156033|]
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shadow of prion protein precursor [Ovis aries]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Shadoo super family cl20877
Shadow of prion protein, neuroprotective; This protein family is a Prion-like protein and its ...
 48-145 6.61e-27

Shadow of prion protein, neuroprotective; This protein family is a Prion-like protein and its function is neuroprotective and similar to PrP(C)-like. Shadoo is mainly expressed in the brain, and highly expressed in the hippocampus, the area of the brain which co-ordinates memory as well as spatial memory and navigation. This protein may also alter the biological actions of normal and abnormal Prion Protein (PrP) which lead to lethal neurodegenerative diseases. This family of proteins is found in eukaryotes. Proteins in this family are approximately 150 amino acids in length, of which the first 90 are alanine rich.


The actual alignment was detected with superfamily member pfam14999:

Pssm-ID: 373461  Cd Length: 133  Bit Score: 97.70  E-value: 6.61e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242247521   48 PAPRY--AGSSVRAAAGAAAGAAAAAGVAAGLAAgSSWRRAAGPAELGLEDAEDGAPGSNGTGRGVYSYWAWTSGAGPTG 125
Cdd:pfam14999  35 PAPRYsaAGSSLRVAAAGAAAGAAAGAAAGLAAG-SGWRRATGPGEGGLEDDEDGAPGGNGTGRGVYSYWAWTSGTGSTH 113

                          90       100
                  ....*....|....*....|
gi 242247521  126 HRHLCPLLGGALGALRLLRP 145
Cdd:pfam14999 114 HPPLCLLLGGALGALELLQP 133
 
Name Accession Description Interval E-value
Shadoo pfam14999
Shadow of prion protein, neuroprotective; This protein family is a Prion-like protein and its ...
 48-145 6.61e-27

Shadow of prion protein, neuroprotective; This protein family is a Prion-like protein and its function is neuroprotective and similar to PrP(C)-like. Shadoo is mainly expressed in the brain, and highly expressed in the hippocampus, the area of the brain which co-ordinates memory as well as spatial memory and navigation. This protein may also alter the biological actions of normal and abnormal Prion Protein (PrP) which lead to lethal neurodegenerative diseases. This family of proteins is found in eukaryotes. Proteins in this family are approximately 150 amino acids in length, of which the first 90 are alanine rich.


Pssm-ID: 373461  Cd Length: 133  Bit Score: 97.70  E-value: 6.61e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242247521   48 PAPRY--AGSSVRAAAGAAAGAAAAAGVAAGLAAgSSWRRAAGPAELGLEDAEDGAPGSNGTGRGVYSYWAWTSGAGPTG 125
Cdd:pfam14999  35 PAPRYsaAGSSLRVAAAGAAAGAAAGAAAGLAAG-SGWRRATGPGEGGLEDDEDGAPGGNGTGRGVYSYWAWTSGTGSTH 113

                          90       100
                  ....*....|....*....|
gi 242247521  126 HRHLCPLLGGALGALRLLRP 145
Cdd:pfam14999 114 HPPLCLLLGGALGALELLQP 133
 
Name Accession Description Interval E-value
Shadoo pfam14999
Shadow of prion protein, neuroprotective; This protein family is a Prion-like protein and its ...
 48-145 6.61e-27

Shadow of prion protein, neuroprotective; This protein family is a Prion-like protein and its function is neuroprotective and similar to PrP(C)-like. Shadoo is mainly expressed in the brain, and highly expressed in the hippocampus, the area of the brain which co-ordinates memory as well as spatial memory and navigation. This protein may also alter the biological actions of normal and abnormal Prion Protein (PrP) which lead to lethal neurodegenerative diseases. This family of proteins is found in eukaryotes. Proteins in this family are approximately 150 amino acids in length, of which the first 90 are alanine rich.


Pssm-ID: 373461  Cd Length: 133  Bit Score: 97.70  E-value: 6.61e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242247521   48 PAPRY--AGSSVRAAAGAAAGAAAAAGVAAGLAAgSSWRRAAGPAELGLEDAEDGAPGSNGTGRGVYSYWAWTSGAGPTG 125
Cdd:pfam14999  35 PAPRYsaAGSSLRVAAAGAAAGAAAGAAAGLAAG-SGWRRATGPGEGGLEDDEDGAPGGNGTGRGVYSYWAWTSGTGSTH 113

                          90       100
                  ....*....|....*....|
gi 242247521  126 HRHLCPLLGGALGALRLLRP 145
Cdd:pfam14999 114 HPPLCLLLGGALGALELLQP 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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