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Conserved domains on  [gi|242054913|ref|XP_002456602|]
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caffeoylshikimate esterase isoform X1 [Sorghum bicolor]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 7-299 4.92e-93

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member PLN02298:

Pssm-ID: 473884 [Multi-domain]  Cd Length: 330  Bit Score: 279.35  E-value: 4.92e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913   7 NIKYEEDFFVNSRGNRLFTCSWTPRKSQS-RALIFICHGYGGECSISMGDTAARLVHRGYAVHGIDHEGHGKSSGSKGYI 85
Cdd:PLN02298  29 GIKGSKSFFTSPRGLSLFTRSWLPSSSSPpRALIFMVHGYGNDISWTFQSTAIFLAQMGFACFALDLEGHGRSEGLRAYV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  86 SSFSDIVRDCSDHFKSVCEKQENGLKKRFLYGFSMGGTVVLQLHRKDPLYWDGAVLLAPFCKMFDNMRPHPIIVSTLKMI 165
Cdd:PLN02298 109 PNVDLVVEDCLSFFNSVKQREEFQGLPRFLYGESMGGAICLLIHLANPEGFDGAVLVAPMCKISDKIRPPWPIPQILTFV 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 166 STVAPSWRVIPAIDMIDKVCKDPQFKKEIRSNPYMYKGNLALQTGRELLSVGLDTEKNLHEVSLPFLVLHGTDDVVADPC 245
Cdd:PLN02298 189 ARFLPTLAIVPTADLLEKSVKVPAKKIIAKRNPMRYNGKPRLGTVVELLRVTDYLGKKLKDVSIPFIVLHGSADVVTDPD 268

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 242054913 246 GSKLLHERASSRDKTLKLYPGMWH-VLMGELPEDVERVFADVISWLDDRVGGTAT 299
Cdd:PLN02298 269 VSRALYEEAKSEDKTIKIYDGMMHsLLFGEPDENIEIVRRDILSWLNERCTGKAT 323
 
Name Accession Description Interval E-value
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 7-299 4.92e-93

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 279.35  E-value: 4.92e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913   7 NIKYEEDFFVNSRGNRLFTCSWTPRKSQS-RALIFICHGYGGECSISMGDTAARLVHRGYAVHGIDHEGHGKSSGSKGYI 85
Cdd:PLN02298  29 GIKGSKSFFTSPRGLSLFTRSWLPSSSSPpRALIFMVHGYGNDISWTFQSTAIFLAQMGFACFALDLEGHGRSEGLRAYV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  86 SSFSDIVRDCSDHFKSVCEKQENGLKKRFLYGFSMGGTVVLQLHRKDPLYWDGAVLLAPFCKMFDNMRPHPIIVSTLKMI 165
Cdd:PLN02298 109 PNVDLVVEDCLSFFNSVKQREEFQGLPRFLYGESMGGAICLLIHLANPEGFDGAVLVAPMCKISDKIRPPWPIPQILTFV 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 166 STVAPSWRVIPAIDMIDKVCKDPQFKKEIRSNPYMYKGNLALQTGRELLSVGLDTEKNLHEVSLPFLVLHGTDDVVADPC 245
Cdd:PLN02298 189 ARFLPTLAIVPTADLLEKSVKVPAKKIIAKRNPMRYNGKPRLGTVVELLRVTDYLGKKLKDVSIPFIVLHGSADVVTDPD 268

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 242054913 246 GSKLLHERASSRDKTLKLYPGMWH-VLMGELPEDVERVFADVISWLDDRVGGTAT 299
Cdd:PLN02298 269 VSRALYEEAKSEDKTIKIYDGMMHsLLFGEPDENIEIVRRDILSWLNERCTGKAT 323
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 33-275 4.81e-74

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 227.87  E-value: 4.81e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913   33 SQSRALIFICHGYGgECSISMGDTAARLVHRGYAVHGIDHEGHGKSSGSKGYISSFSDIVRDCSDHFKSVceKQENGLKK 112
Cdd:pfam12146   1 GEPRAVVVLVHGLG-EHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKI--REEHPGLP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  113 RFLYGFSMGGTVVLQLHRKDPLYWDGAVLLAPFCKMfDNMRPHPIIVSTLKMISTVAPSWRVIPAIDMiDKVCKDPQFKK 192
Cdd:pfam12146  78 LFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKI-KPYLAPPILKLLAKLLGKLFPRLRVPNNLLP-DSLSRDPEVVA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  193 EIRSNPYMyKGNLALQTGRELLSVGLDTEKNLHEVSLPFLVLHGTDDVVADPCGSKLLHERASSRDKTLKLYPGMWHVLM 272
Cdd:pfam12146 156 AYAADPLV-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHELL 234


                  ...
gi 242054913  273 GEL 275
Cdd:pfam12146 235 NEP 237
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
14-292 4.96e-38

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 134.36  E-value: 4.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  14 FFVNSRGNRLFTCSWTPRKsQSRALIFICHGYGgECSISMGDTAARLVHRGYAVHGIDHEGHGKSSGSKGYISSFSDIVR 93
Cdd:COG2267    7 TLPTRDGLRLRGRRWRPAG-SPRGTVVLVHGLG-EHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSFDDYVD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  94 DCsDHFksVCEKQENGLKKRFLYGFSMGGTVVLQLHRKDPLYWDGAVLLAPFckmfdnMRPHPIivstlkmistVAPSWR 173
Cdd:COG2267   85 DL-RAA--LDALRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPA------YRADPL----------LGPSAR 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 174 VIPAIDMIDkvckdpqfkkeirsnpymykgnlalqtgrellsvgldtekNLHEVSLPFLVLHGTDDVVADPCGSKLLHER 253
Cdd:COG2267  146 WLRALRLAE----------------------------------------ALARIDVPVLVLHGGADRVVPPEAARRLAAR 185

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 242054913 254 AsSRDKTLKLYPGMWHVLMGELPEdvERVFADVISWLDD 292
Cdd:COG2267  186 L-SPDVELVLLPGARHELLNEPAR--EEVLAAILAWLER 221
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 59-290 2.49e-12

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 66.73  E-value: 2.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913   59 RLVHRGYAVHGIDHEGHGKSSGS---KGYISSFSDIVRDCSDHFK-----SVCEK----------QENGLKKR---FLYG 117
Cdd:TIGR01607  69 NFNKNGYSVYGLDLQGHGESDGLqnlRGHINCFDDLVYDVIQYMNrindsIILENetksddesydIVNTKENRlpmYIIG 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  118 FSMGGTVVL---QLHRK-----DPLYWDGAVLLAPFCKMFDNMRPHPI-----IVSTLKMISTVAPSWRVIPAIdmidKV 184
Cdd:TIGR01607 149 LSMGGNIALrllELLGKsnennDKLNIKGCISLSGMISIKSVGSDDSFkfkyfYLPVMNFMSRVFPTFRISKKI----RY 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  185 CKDPQFKKEIRSNPYMYKGNLALQTGRELLSVGLDTEKNLHEV--SLPFLVLHGTDDVVADPCGSKLLHERASSRDKTLK 262
Cdd:TIGR01607 225 EKSPYVNDIIKFDKFRYDGGITFNLASELIKATDTLDCDIDYIpkDIPILFIHSKGDCVCSYEGTVSFYNKLSISNKELH 304

                         250       260
                  ....*....|....*....|....*...
gi 242054913  263 LYPGMWHVLMGElPEDvERVFADVISWL 290
Cdd:TIGR01607 305 TLEDMDHVITIE-PGN-EEVLKKIIEWI 330
 
Name Accession Description Interval E-value
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 7-299 4.92e-93

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 279.35  E-value: 4.92e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913   7 NIKYEEDFFVNSRGNRLFTCSWTPRKSQS-RALIFICHGYGGECSISMGDTAARLVHRGYAVHGIDHEGHGKSSGSKGYI 85
Cdd:PLN02298  29 GIKGSKSFFTSPRGLSLFTRSWLPSSSSPpRALIFMVHGYGNDISWTFQSTAIFLAQMGFACFALDLEGHGRSEGLRAYV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  86 SSFSDIVRDCSDHFKSVCEKQENGLKKRFLYGFSMGGTVVLQLHRKDPLYWDGAVLLAPFCKMFDNMRPHPIIVSTLKMI 165
Cdd:PLN02298 109 PNVDLVVEDCLSFFNSVKQREEFQGLPRFLYGESMGGAICLLIHLANPEGFDGAVLVAPMCKISDKIRPPWPIPQILTFV 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 166 STVAPSWRVIPAIDMIDKVCKDPQFKKEIRSNPYMYKGNLALQTGRELLSVGLDTEKNLHEVSLPFLVLHGTDDVVADPC 245
Cdd:PLN02298 189 ARFLPTLAIVPTADLLEKSVKVPAKKIIAKRNPMRYNGKPRLGTVVELLRVTDYLGKKLKDVSIPFIVLHGSADVVTDPD 268

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 242054913 246 GSKLLHERASSRDKTLKLYPGMWH-VLMGELPEDVERVFADVISWLDDRVGGTAT 299
Cdd:PLN02298 269 VSRALYEEAKSEDKTIKIYDGMMHsLLFGEPDENIEIVRRDILSWLNERCTGKAT 323
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 6-294 2.50e-89

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 270.86  E-value: 2.50e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913   6 DNIKYEEDFFVNSRGNRLFTCSWTPRKSQSRALIFICHGYGGECSISMGDTAARLVHRGYAVHGIDHEGHGKSSGSKGYI 85
Cdd:PLN02385  57 SGIKTEESYEVNSRGVEIFSKSWLPENSRPKAAVCFCHGYGDTCTFFFEGIARKIASSGYGVFAMDYPGFGLSEGLHGYI 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  86 SSFSDIVRDCSDHFKSVCEKQENGLKKRFLYGFSMGGTVVLQLHRKDPLYWDGAVLLAPFCKMFDNMRPHPIIVSTLKMI 165
Cdd:PLN02385 137 PSFDDLVDDVIEHYSKIKGNPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAPMCKIADDVVPPPLVLQILILL 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 166 STVAPSWRVIPAIDMIDKVCKDPQFKKEIRSNPYMYKGNLALQTGRELLSVGLDTEKNLHEVSLPFLVLHGTDDVVADPC 245
Cdd:PLN02385 217 ANLLPKAKLVPQKDLAELAFRDLKKRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHGEADKVTDPS 296

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 242054913 246 GSKLLHERASSRDKTLKLYPGMWH-VLMGELPEDVERVFADVISWLDDRV 294
Cdd:PLN02385 297 VSKFLYEKASSSDKKLKLYEDAYHsILEGEPDEMIFQVLDDIISWLDSHS 346
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 33-275 4.81e-74

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 227.87  E-value: 4.81e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913   33 SQSRALIFICHGYGgECSISMGDTAARLVHRGYAVHGIDHEGHGKSSGSKGYISSFSDIVRDCSDHFKSVceKQENGLKK 112
Cdd:pfam12146   1 GEPRAVVVLVHGLG-EHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKI--REEHPGLP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  113 RFLYGFSMGGTVVLQLHRKDPLYWDGAVLLAPFCKMfDNMRPHPIIVSTLKMISTVAPSWRVIPAIDMiDKVCKDPQFKK 192
Cdd:pfam12146  78 LFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKI-KPYLAPPILKLLAKLLGKLFPRLRVPNNLLP-DSLSRDPEVVA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  193 EIRSNPYMyKGNLALQTGRELLSVGLDTEKNLHEVSLPFLVLHGTDDVVADPCGSKLLHERASSRDKTLKLYPGMWHVLM 272
Cdd:pfam12146 156 AYAADPLV-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHELL 234


                  ...
gi 242054913  273 GEL 275
Cdd:pfam12146 235 NEP 237
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 1-296 5.18e-41

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 146.96  E-value: 5.18e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913   1 MAQYRDNIKYEEDFFVNSRGNRLFTCSWTPRKSQSRALIFICHGYGgECSISMGDTAARLVHRGYAVHGIDHEGHGKSSG 80
Cdd:PLN02652 101 MVEDGEGTRWATSLFYGARRNALFCRSWAPAAGEMRGILIIIHGLN-EHSGRYLHFAKQLTSCGFGVYAMDWIGHGGSDG 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  81 SKGYISSFSDIVRDCSDHFKSVceKQENGLKKRFLYGFSMGGTVVLQL----HRKDPLywDGAVLLAPFCKMfdnmRP-H 155
Cdd:PLN02652 180 LHGYVPSLDYVVEDTEAFLEKI--RSENPGVPCFLFGHSTGGAVVLKAasypSIEDKL--EGIVLTSPALRV----KPaH 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 156 PIIVSTLKMISTVAPSWRVIPAIDMIDKVCKDPQFKKEIRSNPYMYKGNLALQTGRELLSVGLDTEKNLHEVSLPFLVLH 235
Cdd:PLN02652 252 PIVGAVAPIFSLVAPRFQFKGANKRGIPVSRDPAALLAKYSDPLVYTGPIRVRTGHEILRISSYLTRNFKSVTVPFMVLH 331

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 242054913 236 GTDDVVADPCGSKLLHERASSRDKTLKLYPGMWHVLMGElPEDvERVFADVISWLDDRVGG 296
Cdd:PLN02652 332 GTADRVTDPLASQDLYNEAASRHKDIKLYDGFLHDLLFE-PER-EEVGRDIIDWMEKRLDL 390
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
14-292 4.96e-38

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 134.36  E-value: 4.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  14 FFVNSRGNRLFTCSWTPRKsQSRALIFICHGYGgECSISMGDTAARLVHRGYAVHGIDHEGHGKSSGSKGYISSFSDIVR 93
Cdd:COG2267    7 TLPTRDGLRLRGRRWRPAG-SPRGTVVLVHGLG-EHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSFDDYVD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  94 DCsDHFksVCEKQENGLKKRFLYGFSMGGTVVLQLHRKDPLYWDGAVLLAPFckmfdnMRPHPIivstlkmistVAPSWR 173
Cdd:COG2267   85 DL-RAA--LDALRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPA------YRADPL----------LGPSAR 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 174 VIPAIDMIDkvckdpqfkkeirsnpymykgnlalqtgrellsvgldtekNLHEVSLPFLVLHGTDDVVADPCGSKLLHER 253
Cdd:COG2267  146 WLRALRLAE----------------------------------------ALARIDVPVLVLHGGADRVVPPEAARRLAAR 185

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 242054913 254 AsSRDKTLKLYPGMWHVLMGELPEdvERVFADVISWLDD 292
Cdd:COG2267  186 L-SPDVELVLLPGARHELLNEPAR--EEVLAAILAWLER 221
PHA02857 PHA02857
monoglyceride lipase; Provisional
 13-294 6.23e-26

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 104.20  E-value: 6.23e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  13 DFFVNSRGNRLFTCSWTPrKSQSRALIFICHGyGGECSISMGDTAARLVHRGYAVHGIDHEGHGKSSGSKGYISSFSDIV 92
Cdd:PHA02857   3 NCMFNLDNDYIYCKYWKP-ITYPKALVFISHG-AGEHSGRYEELAENISSLGILVFSHDHIGHGRSNGEKMMIDDFGVYV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  93 RDCSDH---FKSVCEKQenglkKRFLYGFSMGGTVVLQLHRKDPLYWDGAVLLAPFCKMfDNMRPHPIIVStlKMISTVA 169
Cdd:PHA02857  81 RDVVQHvvtIKSTYPGV-----PVFLLGHSMGATISILAAYKNPNLFTAMILMSPLVNA-EAVPRLNLLAA--KLMGIFY 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 170 PSwRVIPAIDmIDKVCKDPQFKKEIRSNPYMYKGNLALQTGRELLSVGLDTEKNLHEVSLPFLVLHGTDDVVADPCGSKL 249
Cdd:PHA02857 153 PN-KIVGKLC-PESVSRDMDEVYKYQYDPLVNHEKIKAGFASQVLKATNKVRKIIPKIKTPILILQGTNNEISDVSGAYY 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 242054913 250 LHERASSrDKTLKLYPGMWHVLMGELPEDVERVFADVISWLDDRV 294
Cdd:PHA02857 231 FMQHANC-NREIKIYEGAKHHLHKETDEVKKSVMKEIETWIFNRV 274
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
39-295 2.16e-25

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 101.94  E-value: 2.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  39 IFICHGYGGeCSISMGDTAARLVHRGYAVHGIDHEGHGKSSG--SKgyiSSFSDIVRDCSDHFKSVCEKQEnglkKRFLY 116
Cdd:COG1647   18 VLLLHGFTG-SPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEdlLK---TTWEDWLEDVEEAYEILKAGYD----KVIVI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 117 GFSMGGTVVLQL--HRKDPlywDGAVLLAPfckmfdNMRPHPIIVSTLKMISTVAPSWRVIPAIDmidkvcKDPQFKKE- 193
Cdd:COG1647   90 GLSMGGLLALLLaaRYPDV---AGLVLLSP------ALKIDDPSAPLLPLLKYLARSLRGIGSDI------EDPEVAEYa 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 194 IRSNPymykgnlaLQTGRELLSVGLDTEKNLHEVSLPFLVLHGTDDVVADPCGSKLLHERASSRDKTLKLYPGMWHVLMg 273
Cdd:COG1647  155 YDRTP--------LRALAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVIT- 225

                        250       260
                 ....*....|....*....|..
gi 242054913 274 eLPEDVERVFADVISWLDDRVG 295
Cdd:COG1647  226 -LDKDREEVAEEILDFLERLAA 246
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
29-295 2.75e-20

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 87.76  E-value: 2.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  29 TPRKSQSRALIFICHGYGGECSISMGDTAARLVHRGYAVHGIDHEGHGKSSGSKGYissfsDIVRDCSDHFKSVCEKQEN 108
Cdd:COG1506   16 LPADGKKYPVVVYVHGGPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGG-----DEVDDVLAAIDYLAARPYV 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 109 GLKKRFLYGFSMGGTVVLQLHRKDPLYWDGAVLLAPfckmfdnmrphpiiVSTLKMISTVAPSWRvipaidmiDKVCKDP 188
Cdd:COG1506   91 DPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAG--------------VSDLRSYYGTTREYT--------ERLMGGP 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 189 QfkkeirSNPYMYKGNlalqtgrellsvglDTEKNLHEVSLPFLVLHGTDDVVADPCGSKLLHERASSR--DKTLKLYPG 266
Cdd:COG1506  149 W------EDPEAYAAR--------------SPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKAgkPVELLVYPG 208

                        250       260
                 ....*....|....*....|....*....
gi 242054913 267 MWHvlmGELPEDVERVFADVISWLDDRVG 295
Cdd:COG1506  209 EGH---GFSGAGAPDYLERILDFLDRHLK 234
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 5-292 1.11e-17

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 80.73  E-value: 1.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913   5 RDNIKYEEDFFVNSRGNRLFTCSWTPRK-SQSRALIFICHGYGGeCSISMGDTAARLVHRGYAVHGIDHEGHGKSSGSKG 83
Cdd:COG1073    5 SDKVNKEDVTFKSRDGIKLAGDLYLPAGaSKKYPAVVVAHGNGG-VKEQRALYAQRLAELGFNVLAFDYRGYGESEGEPR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  84 YISSFSdiVRDCSDHFKSVCEKQENGLKKRFLYGFSMGGTVVLQLHRKDPLYwDGAVLLApfckMFDNMRphpiivstlk 163
Cdd:COG1073   84 EEGSPE--RRDARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPRV-KAVILDS----PFTSLE---------- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 164 mistvapswrvipaiDMIDKVCKDpQFKKEIRSNPYMYKGNLAlqtgrELLSVGLDTEKNLHEVSLPFLVLHGTDDvVAD 243
Cdd:COG1073  147 ---------------DLAAQRAKE-ARGAYLPGVPYLPNVRLA-----SLLNDEFDPLAKIEKISRPLLFIHGEKD-EAV 204

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 242054913 244 PCG-SKLLHERASSrDKTLKLYPGMWHVLMGELPEdvERVFADVISWLDD 292
Cdd:COG1073  205 PFYmSEDLYEAAAE-PKELLIVPGAGHVDLYDRPE--EEYFDKLAEFFKK 251
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 36-291 1.80e-13

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 68.49  E-value: 1.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  36 RALIFIcHGYGGecSISMGDTAARLVHRGYAVHGIDHEGHGKSSGSKGYISsFSDIVRDCSDhfksVCEkqENGLKKRFL 115
Cdd:COG0596   24 PPVVLL-HGLPG--SSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYT-LDDLADDLAA----LLD--ALGLERVVL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 116 YGFSMGGTVVLQLHRKDPLYWDGAVLLAPFCKMFDNMrphpiivstlkmistvapswrvipaidMIDKVCKDPQFKKEIR 195
Cdd:COG0596   94 VGHSMGGMVALELAARHPERVAGLVLVDEVLAALAEP---------------------------LRRPGLAPEALAALLR 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 196 SNpymykgnlalqtgrellsVGLDTEKNLHEVSLPFLVLHGTDDVVADPCGSKLLHERAssRDKTLKLYPGMWHVLMGEL 275
Cdd:COG0596  147 AL------------------ARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELL--PNAELVVLPGAGHFPPLEQ 206

                        250
                 ....*....|....*.
gi 242054913 276 PedvERVFADVISWLD 291
Cdd:COG0596  207 P---EAFAAALRDFLA 219
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 59-290 2.49e-12

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 66.73  E-value: 2.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913   59 RLVHRGYAVHGIDHEGHGKSSGS---KGYISSFSDIVRDCSDHFK-----SVCEK----------QENGLKKR---FLYG 117
Cdd:TIGR01607  69 NFNKNGYSVYGLDLQGHGESDGLqnlRGHINCFDDLVYDVIQYMNrindsIILENetksddesydIVNTKENRlpmYIIG 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  118 FSMGGTVVL---QLHRK-----DPLYWDGAVLLAPFCKMFDNMRPHPI-----IVSTLKMISTVAPSWRVIPAIdmidKV 184
Cdd:TIGR01607 149 LSMGGNIALrllELLGKsnennDKLNIKGCISLSGMISIKSVGSDDSFkfkyfYLPVMNFMSRVFPTFRISKKI----RY 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  185 CKDPQFKKEIRSNPYMYKGNLALQTGRELLSVGLDTEKNLHEV--SLPFLVLHGTDDVVADPCGSKLLHERASSRDKTLK 262
Cdd:TIGR01607 225 EKSPYVNDIIKFDKFRYDGGITFNLASELIKATDTLDCDIDYIpkDIPILFIHSKGDCVCSYEGTVSFYNKLSISNKELH 304

                         250       260
                  ....*....|....*....|....*...
gi 242054913  263 LYPGMWHVLMGElPEDvERVFADVISWL 290
Cdd:TIGR01607 305 TLEDMDHVITIE-PGN-EEVLKKIIEWI 330
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
28-293 8.32e-08

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 52.80  E-value: 8.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  28 WTPRKSQSRA-------LIFICHGYGGECSiSMGDTAARLVHRGYAVHGIDHEGH---GKSSGSKGYISSFSDI-----V 92
Cdd:COG4188   47 WYPATAPADApaggpfpLVVLSHGLGGSRE-GYAYLAEHLASHGYVVAAPDHPGSnaaDLSAALDGLADALDPEelwerP 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  93 RDCS---DHFKSVcEKQENGLKKRF------LYGFSMGGTVVLQLhrkdplywDGAVL----LAPFCKmfdnmrPHPIIV 159
Cdd:COG4188  126 LDLSfvlDQLLAL-NKSDPPLAGRLdldrigVIGHSLGGYTALAL--------AGARLdfaaLRQYCG------KNPDLQ 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 160 STLKMISTVAPSWRvipaidmidkvckDPQFKKEIRSNPYMykgnlalqtgrellsVGLDTEKNLHEVSLPFLVLHGT-D 238
Cdd:COG4188  191 CRALDLPRLAYDLR-------------DPRIKAVVALAPGG---------------SGLFGEEGLAAITIPVLLVAGSaD 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 242054913 239 DVVADPCGSKLLHERASSRDKTLKLYPGMWHVLMGELPEDVERVFADVISWLDDR 293
Cdd:COG4188  243 DVTPAPDEQIRPFDLLPGADKYLLTLEGATHFSFLDPCTPGAAILPEPDPPGPDR 297
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 38-150 1.22e-07

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 51.74  E-value: 1.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913   38 LIFICHGYGG--ECSISMGDTAARlvhRGYAVHGIDHEGHGKSSGSKgyissfsdivrDCSD-HFKSVCE-----KQENG 109
Cdd:pfam00561   2 PVLLLHGLPGssDLWRKLAPALAR---DGFRVIALDLRGFGKSSRPK-----------AQDDyRTDDLAEdleyiLEALG 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 242054913  110 LKKRFLYGFSMGGTVVLQLHRKDPLYWDGAVLLAPFCKMFD 150
Cdd:pfam00561  68 LEKVNLVGHSMGGLIALAYAAKYPDRVKALVLLGALDPPHE 108
PRK10749 PRK10749
lysophospholipase L2; Provisional
 31-156 2.45e-07

lysophospholipase L2; Provisional


Pssm-ID: 182697  Cd Length: 330  Bit Score: 51.54  E-value: 2.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  31 RKSQSRALIFICHGYGgECSISMGDTAARLVHRGYAVHGIDHEGHGKSS-----GSKGYISSFSDIVRDcsdhFKSVCEK 105
Cdd:PRK10749  49 RAPHHDRVVVICPGRI-ESYVKYAELAYDLFHLGYDVLIIDHRGQGRSGrllddPHRGHVERFNDYVDD----LAAFWQQ 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 242054913 106 Q--ENGLKKRFLYGFSMGGTVVLQLHRKDPLYWDGAVLLAPfckMFDNMRPHP 156
Cdd:PRK10749 124 EiqPGPYRKRYALAHSMGGAILTLFLQRHPGVFDAIALCAP---MFGIVLPLP 173
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 39-282 2.97e-07

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 50.16  E-value: 2.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913   39 IFICHGyGGECSISMgdtaARLVHRGYAVHGIDHEGHGKSSGSkgyISSFSDiVRDCSDHFKSVcekqeNGLKKRFLYGF 118
Cdd:pfam12697   1 VVLVHG-AGLSAAPL----AALLAAGVAVLAPDLPGHGSSSPP---PLDLAD-LADLAALLDEL-----GAARPVVLVGH 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  119 SMGGTVVLQLhrkDPLYWDGAVLLAPFCKMFDNMRPHPIIvstlkmistVAPSWRVIPAIDMIDKVCKDPQFkkeIRSNP 198
Cdd:pfam12697  67 SLGGAVALAA---AAAALVVGVLVAPLAAPPGLLAALLAL---------LARLGAALAAPAWLAAESLARGF---LDDLP 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  199 YMYKGNLALQTGRELLS-VGLDTEKNLHEVSLPFLVLHGTDDVVADPCGSKLlherASSRDKTLKLYPGMWHVLMGElPE 277
Cdd:pfam12697 132 ADAEWAAALARLAALLAaLALLPLAAWRDLPVPVLVLAEEDRLVPELAQRLL----AALAGARLVVLPGAGHLPLDD-PE 206


                  ....*
gi 242054913  278 DVERV 282
Cdd:pfam12697 207 EVAEA 211
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
230-295 5.92e-05

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 43.32  E-value: 5.92e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913 230 PFLVLHGTDDVVADpcGSKLLHER--ASSRDKTLKLYPGMWHV--LMGELPEDvERVFADVISWLDDRVG 295
Cdd:COG0657  141 PTLIVTGEADPLVD--ESEALAAAlrAAGVPVELHVYPGGGHGfgLLAGLPEA-RAALAEIAAFLRRALA 207
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
26-126 1.62e-03

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 39.74  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242054913  26 CSWTPRKSQSRALIFICHGYGGeCSIS--MGDTAARLVHRGYAVHGIDHEGHGKSSG--SKGYISSFSDIVRDCSDHFKs 101
Cdd:COG0429   51 LDWSDPPAPSKPLVVLLHGLEG-SSDShyARGLARALYARGWDVVRLNFRGCGGEPNllPRLYHSGDTEDLVWVLAHLR- 128

                         90       100
                 ....*....|....*....|....*
gi 242054913 102 vcekQENGLKKRFLYGFSMGGTVVL 126
Cdd:COG0429  129 ----ARYPYAPLYAVGFSLGGNLLL 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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