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Conserved domains on  [gi|241934314|gb|EES07459|]
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hypothetical protein SORBI_3004G283000 [Sorghum bicolor]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
139-422 5.18e-40

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 147.75  E-value: 5.18e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 139 LTPLKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWDCQTGQCAGIIPVGRE-VGCMII--EGPWLFVGMPD-AVKVWNMQ 214
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGaVTSVAFspDGKLLASGSDDgTVRLWDLA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 215 TAAEM-SLTGPTGQVYALAVA--SELLFAATQDGRILAWrfSAATNcfEPAASLDGHKLAVVSLIV--GGMRLYSASMDK 289
Cdd:COG2319  193 TGKLLrTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLW--DLATG--KLLRTLTGHSGSVRSVAFspDGRLLASGSADG 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 290 TIRVWDLATLQCIQTLSDHTDVVMSVlCW---DQFLLSCSLDQTIKVWAAtESGNLEVTYT-HKEDQGALALSgmPDAQs 365
Cdd:COG2319  269 TVRLWDLATGELLRTLTGHSGGVNSV-AFspdGKLLASGSDDGTVRLWDL-ATGKLLRTLTgHTGAVRSVAFS--PDGK- 343

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 241934314 366 kpVLLCSLNDNTVRLYDLPSFNDRGRLFS-KQEIRAIQMGP-GGLFFTGDGTGELKVWQ 422
Cdd:COG2319  344 --TLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPdGRTLASGSADGTVRLWD 400
ZnF_C3H1 smart00356
zinc finger;
107-130 7.14e-04

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 36.84  E-value: 7.14e-04
                           10        20
                   ....*....|....*....|....
gi 241934314   107 RPCKFFLAGTeCSYGERCRYPHSY 130
Cdd:smart00356   5 ELCKFFKRGY-CPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
139-422 5.18e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 147.75  E-value: 5.18e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 139 LTPLKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWDCQTGQCAGIIPVGRE-VGCMII--EGPWLFVGMPD-AVKVWNMQ 214
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGaVTSVAFspDGKLLASGSDDgTVRLWDLA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 215 TAAEM-SLTGPTGQVYALAVA--SELLFAATQDGRILAWrfSAATNcfEPAASLDGHKLAVVSLIV--GGMRLYSASMDK 289
Cdd:COG2319  193 TGKLLrTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLW--DLATG--KLLRTLTGHSGSVRSVAFspDGRLLASGSADG 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 290 TIRVWDLATLQCIQTLSDHTDVVMSVlCW---DQFLLSCSLDQTIKVWAAtESGNLEVTYT-HKEDQGALALSgmPDAQs 365
Cdd:COG2319  269 TVRLWDLATGELLRTLTGHSGGVNSV-AFspdGKLLASGSDDGTVRLWDL-ATGKLLRTLTgHTGAVRSVAFS--PDGK- 343

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 241934314 366 kpVLLCSLNDNTVRLYDLPSFNDRGRLFS-KQEIRAIQMGP-GGLFFTGDGTGELKVWQ 422
Cdd:COG2319  344 --TLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPdGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 142-422 2.26e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 2.26e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 142 LKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWDCQTGQC-----AGIIPVGRevgCMII-EGPWLF-VGMPDAVKVWNMQ 214
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELlrtlkGHTGPVRD---VAASaDGTYLAsGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 215 TAAE-MSLTGPTGQVYALAV--ASELLFAATQDGRILAWRFSAATNCFepaaSLDGHKLAVVSLIV--GGMRLYSASMDK 289
Cdd:cd00200   82 TGECvRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKCLT----TLRGHTDWVNSVAFspDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 290 TIRVWDLATLQCIQTLSDHTDVVMSVlCWD---QFLLSCSLDQTIKVWaATESGNLEVTYTHKEDqGALALSGMPDAQsk 366
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSV-AFSpdgEKLLSSSSDGTIKLW-DLSTGKCLGTLRGHEN-GVNSVAFSPDGY-- 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 241934314 367 pVLLCSLNDNTVRLYDLPSFNDRGRLFSKQE-IRAIQMGP-GGLFFTGDGTGELKVWQ 422
Cdd:cd00200  233 -LLASGSEDGTIRVWDLRTGECVQTLSGHTNsVTSLAWSPdGKRLASGSADGTIRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 238-333 9.35e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.13  E-value: 9.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 238 LFAATQDGRILAWRFSA---ATNCFEPAASLDGH--KLAVVSLIVGGMR-LYSASMDKTIRVWDLATLQCIQTLSDHTDV 311
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeglTQNISDPIVHLQGHtkKVGIVSFHPSAMNvLASAGADMVVNVWDVERGKAVEVIKCHSDQ 170

                         90       100
                 ....*....|....*....|....*
gi 241934314 312 VMSvLCWD---QFLLSCSLDQTIKV 333
Cdd:PTZ00421 171 ITS-LEWNldgSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
142-174 3.00e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 3.00e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 241934314  142 LKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWD 174
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-174 1.01e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.01e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 241934314   142 LKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWD 174
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ZnF_C3H1 smart00356
zinc finger;
107-130 7.14e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 36.84  E-value: 7.14e-04
                           10        20
                   ....*....|....*....|....
gi 241934314   107 RPCKFFLAGTeCSYGERCRYPHSY 130
Cdd:smart00356   5 ELCKFFKRGY-CPRGDRCKFAHPL 27
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 109-128 1.24e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 35.86  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|
gi 241934314  109 CKFFLAGTeCSYGERCRYPH 128
Cdd:pfam18345   1 CKFFLKGR-CRYGDKCRFAH 19
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
139-422 5.18e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 147.75  E-value: 5.18e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 139 LTPLKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWDCQTGQCAGIIPVGRE-VGCMII--EGPWLFVGMPD-AVKVWNMQ 214
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGaVTSVAFspDGKLLASGSDDgTVRLWDLA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 215 TAAEM-SLTGPTGQVYALAVA--SELLFAATQDGRILAWrfSAATNcfEPAASLDGHKLAVVSLIV--GGMRLYSASMDK 289
Cdd:COG2319  193 TGKLLrTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLW--DLATG--KLLRTLTGHSGSVRSVAFspDGRLLASGSADG 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 290 TIRVWDLATLQCIQTLSDHTDVVMSVlCW---DQFLLSCSLDQTIKVWAAtESGNLEVTYT-HKEDQGALALSgmPDAQs 365
Cdd:COG2319  269 TVRLWDLATGELLRTLTGHSGGVNSV-AFspdGKLLASGSDDGTVRLWDL-ATGKLLRTLTgHTGAVRSVAFS--PDGK- 343

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 241934314 366 kpVLLCSLNDNTVRLYDLPSFNDRGRLFS-KQEIRAIQMGP-GGLFFTGDGTGELKVWQ 422
Cdd:COG2319  344 --TLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPdGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 142-422 2.26e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 2.26e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 142 LKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWDCQTGQC-----AGIIPVGRevgCMII-EGPWLF-VGMPDAVKVWNMQ 214
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELlrtlkGHTGPVRD---VAASaDGTYLAsGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 215 TAAE-MSLTGPTGQVYALAV--ASELLFAATQDGRILAWRFSAATNCFepaaSLDGHKLAVVSLIV--GGMRLYSASMDK 289
Cdd:cd00200   82 TGECvRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKCLT----TLRGHTDWVNSVAFspDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 290 TIRVWDLATLQCIQTLSDHTDVVMSVlCWD---QFLLSCSLDQTIKVWaATESGNLEVTYTHKEDqGALALSGMPDAQsk 366
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSV-AFSpdgEKLLSSSSDGTIKLW-DLSTGKCLGTLRGHEN-GVNSVAFSPDGY-- 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 241934314 367 pVLLCSLNDNTVRLYDLPSFNDRGRLFSKQE-IRAIQMGP-GGLFFTGDGTGELKVWQ 422
Cdd:cd00200  233 -LLASGSEDGTIRVWDLRTGECVQTLSGHTNsVTSLAWSPdGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
139-385 4.05e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 139.66  E-value: 4.05e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 139 LTPLKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWDCQTGQCAGIIPV-GREVGCMII--EGPWLFVGMPD-AVKVWNMQ 214
Cdd:COG2319  155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFspDGKLLASGSADgTVRLWDLA 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 215 TAAEM-SLTGPTGQVYALAVA--SELLFAATQDGRILAWRfsAATNcfEPAASLDGHKLAVVSLIV--GGMRLYSASMDK 289
Cdd:COG2319  235 TGKLLrTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLWD--LATG--ELLRTLTGHSGGVNSVAFspDGKLLASGSDDG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 290 TIRVWDLATLQCIQTLSDHTDVVMSVlCW---DQFLLSCSLDQTIKVWAATESGNLEVTYTHKEDQGALALSgmPDAQsk 366
Cdd:COG2319  311 TVRLWDLATGKLLRTLTGHTGAVRSV-AFspdGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS--PDGR-- 385

                        250
                 ....*....|....*....
gi 241934314 367 pVLLCSLNDNTVRLYDLPS 385
Cdd:COG2319  386 -TLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
139-428 1.04e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.64  E-value: 1.04e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 139 LTPLKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWDCQTGQCAGIipvgrevgcmiiegpwlfvgmpdavkvwnmqtaae 218
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT----------------------------------- 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 219 msLTGPTGQVYALAVAS--ELLFAATQDGRILAWrfSAATNcfEPAASLDGHKLAVVSLIV--GGMRLYSASMDKTIRVW 294
Cdd:COG2319  116 --LTGHTGAVRSVAFSPdgKTLASGSADGTVRLW--DLATG--KLLRTLTGHSGAVTSVAFspDGKLLASGSDDGTVRLW 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 295 DLATLQCIQTLSDHTDVVMSVlCWD---QFLLSCSLDQTIKVWAAtESGNLEVTYTHKEDQ-GALALSgmPDAQskpVLL 370
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRSV-AFSpdgKLLASGSADGTVRLWDL-ATGKLLRTLTGHSGSvRSVAFS--PDGR---LLA 262

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 371 CSLNDNTVRLYDLPSFNDRGRL-FSKQEIRAIQMGPGG-LFFTGDGTGELKVWQWVDGAQ 428
Cdd:COG2319  263 SGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-335 3.33e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 3.33e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 139 LTPLKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWDCQTGQCagiipvgrevgcmiiegpwlfvgmpdavkvwnMQTaae 218
Cdd:cd00200  128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC--------------------------------VAT--- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 219 msLTGPTGQVYALAVA--SELLFAATQDGRILAWRFSAatncFEPAASLDGHKLAVVSLIVGGMRLY--SASMDKTIRVW 294
Cdd:cd00200  173 --LTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLST----GKCLGTLRGHENGVNSVAFSPDGYLlaSGSEDGTIRVW 246

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 241934314 295 DLATLQCIQTLSDHTDVVMSVlCWD---QFLLSCSLDQTIKVWA 335
Cdd:cd00200  247 DLRTGECVQTLSGHTNSVTSL-AWSpdgKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
214-428 8.50e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 8.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 214 QTAAEMSLTGPTGQVYALAVASELLFAATQDGRILAWRFSAATNcfEPAASLDGHKLAVVSLIV--GGMRLYSASMDKTI 291
Cdd:COG2319   25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG--ALLATLLGHTAAVLSVAFspDGRLLASASADGTV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 292 RVWDLATLQCIQTLSDHTDVVMSVlCWD---QFLLSCSLDQTIKVWAAtESGNLEVTYT-HKEDQGALALSgmPDAQskp 367
Cdd:COG2319  103 RLWDLATGLLLRTLTGHTGAVRSV-AFSpdgKTLASGSADGTVRLWDL-ATGKLLRTLTgHSGAVTSVAFS--PDGK--- 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 241934314 368 VLLCSLNDNTVRLYDLPSFNDRGRL-FSKQEIRAIQMGPGG-LFFTGDGTGELKVWQWVDGAQ 428
Cdd:COG2319  176 LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKL 238
WD40 COG2319
WD40 repeat [General function prediction only];
232-428 1.09e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 1.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 232 AVASELLFAATQDGRILAWRFSAATNCFEPAASLDGHKLAVVSLIVGGMRLYSASMDKTIRVWDLATLQCIQTLSDHTDV 311
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 312 VMSVLCW--DQFLLSCSLDQTIKVWAATESGNLEVTYTHKEDQGALALSgmPDAQskpVLLCSLNDNTVRLYDLPSFNDR 389
Cdd:COG2319   81 VLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDGK---TLASGSADGTVRLWDLATGKLL 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 241934314 390 GRLFSKQE-IRAIQMGPGG-LFFTGDGTGELKVWQWVDGAQ 428
Cdd:COG2319  156 RTLTGHSGaVTSVAFSPDGkLLASGSDDGTVRLWDLATGKL 196
PTZ00421 PTZ00421
coronin; Provisional
 238-333 9.35e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.13  E-value: 9.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314 238 LFAATQDGRILAWRFSA---ATNCFEPAASLDGH--KLAVVSLIVGGMR-LYSASMDKTIRVWDLATLQCIQTLSDHTDV 311
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeglTQNISDPIVHLQGHtkKVGIVSFHPSAMNvLASAGADMVVNVWDVERGKAVEVIKCHSDQ 170

                         90       100
                 ....*....|....*....|....*
gi 241934314 312 VMSvLCWD---QFLLSCSLDQTIKV 333
Cdd:PTZ00421 171 ITS-LEWNldgSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
142-174 3.00e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 3.00e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 241934314  142 LKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWD 174
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-174 1.01e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.01e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 241934314   142 LKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWD 174
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 298-334 1.21e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.21e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 241934314   298 TLQCIQTLSDHTDVVMSVlCWD---QFLLSCSLDQTIKVW 334
Cdd:smart00320   1 SGELLKTLKGHTGPVTSV-AFSpdgKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
300-334 8.70e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 8.70e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 241934314  300 QCIQTLSDHTDVVMSVlCWD---QFLLSCSLDQTIKVW 334
Cdd:pfam00400   2 KLLKTLEGHTGSVTSL-AFSpdgKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
134-177 1.28e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 1.28e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 241934314 134 DSVTMLTPLKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWDCQT 177
Cdd:COG2319  360 ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 259-295 2.87e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.87e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 241934314   259 FEPAASLDGHKLAVVSLIV--GGMRLYSASMDKTIRVWD 295
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
ZnF_C3H1 smart00356
zinc finger;
107-130 7.14e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 36.84  E-value: 7.14e-04
                           10        20
                   ....*....|....*....|....
gi 241934314   107 RPCKFFLAGTeCSYGERCRYPHSY 130
Cdd:smart00356   5 ELCKFFKRGY-CPRGDRCKFAHPL 27
Nup160 pfam11715
Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous ...
 230-318 1.13e-03

Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 sub-complex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 sub-complex, but rather that it regulates the association of the sub-complex with the NPC and other proteins.


Pssm-ID: 432020 [Multi-domain]  Cd Length: 540  Bit Score: 41.29  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241934314  230 ALAVASELLFAATQDGRILAWRFSAA-----TNCFEPAASLDGHKL------------------AVVSLIVGGMR----- 281
Cdd:pfam11715 156 LVAVSPLELLVSLADGGLLKLTRSSDggawkESTFEPASWLQSLSGllgwladptirysgssvaLSLSAAPAVTTvggqn 235

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 241934314  282 -LYSASMDKTIRVWDLATLQCIQTLS-DHTDVVMSVLCW 318
Cdd:pfam11715 236 fLFTLSLDHTLRVWDLLTGKCLATIDlLDLELPQDSSSW 274
WD40 pfam00400
WD domain, G-beta repeat;
259-295 1.24e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.24e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 241934314  259 FEPAASLDGHKLAVVSLIV--GGMRLYSASMDKTIRVWD 295
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 109-128 1.24e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 35.86  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|
gi 241934314  109 CKFFLAGTeCSYGERCRYPH 128
Cdd:pfam18345   1 CKFFLKGR-CRYGDKCRFAH 19
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
107-129 1.52e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 35.63  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|...
gi 241934314  107 RPCKFFLAGTECSYGERCRYPHS 129
Cdd:pfam00642   4 ELCRFFLRTGYCKYGDRCKFAHG 26
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-174 2.39e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 2.39e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 241934314 133 SDSVTMLTPLKGHEKGVTGIALPAGSDKLYSGSKDGTVRMWD 174
Cdd:cd00200  248 LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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