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Conserved domains on  [gi|240860233|gb|ACS57900|]
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sarcosine oxidase, gamma subunit family [Rhizobium leguminosarum bv. trifolii WSM1325]

Protein Classification

sarcosine oxidase subunit gamma( domain architecture ID 10008634)

sarcosine oxidase subunit gamma (SoxG) is part of a heterotetrameric enzyme that catalyzes the oxidative demethylation of sarcosine to yield glycine, hydrogen peroxide and 5,10-methylenetetrahydrofolate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SoxG COG4583
Sarcosine oxidase gamma subunit [Amino acid transport and metabolism];
20-181 4.64e-50

Sarcosine oxidase gamma subunit [Amino acid transport and metabolism];


:

Pssm-ID: 443640  Cd Length: 169  Bit Score: 158.88  E-value: 4.64e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240860233  20 AVRLTTAPTASRVALRAPAES---LSALSSALGLTLPDAPKTSGrAGARSALWIGPDEWLVIDEAGAG--LMAALSAA-- 92
Cdd:COG4583    1 GVTLREVPPLGLVSLRARPGQealAAALKAALGLALPAPPRVAA-AGGRAALWLGPDEWLLLAPYGAAedLAAALAAAla 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240860233  93 GTLHSATDVSHRNVAIIVSGPGAEATLSGGCPQDLSLSSFPVGAASRTVFGKAEIVLFRTEEDTFRVECWRSFSDYVFGL 172
Cdd:COG4583   80 GLHAAVVDVSDGRTVFELSGPRARDVLAKLCPLDLHPRAFPVGAAARTVLAHVGVVLWRTGEDRFRLLVRRSFADYLWHW 159


                 ....*....
gi 240860233 173 LNEAAEDAG 181
Cdd:COG4583  160 LEDAAREYG 168
 
Name Accession Description Interval E-value
SoxG COG4583
Sarcosine oxidase gamma subunit [Amino acid transport and metabolism];
20-181 4.64e-50

Sarcosine oxidase gamma subunit [Amino acid transport and metabolism];


Pssm-ID: 443640  Cd Length: 169  Bit Score: 158.88  E-value: 4.64e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240860233  20 AVRLTTAPTASRVALRAPAES---LSALSSALGLTLPDAPKTSGrAGARSALWIGPDEWLVIDEAGAG--LMAALSAA-- 92
Cdd:COG4583    1 GVTLREVPPLGLVSLRARPGQealAAALKAALGLALPAPPRVAA-AGGRAALWLGPDEWLLLAPYGAAedLAAALAAAla 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240860233  93 GTLHSATDVSHRNVAIIVSGPGAEATLSGGCPQDLSLSSFPVGAASRTVFGKAEIVLFRTEEDTFRVECWRSFSDYVFGL 172
Cdd:COG4583   80 GLHAAVVDVSDGRTVFELSGPRARDVLAKLCPLDLHPRAFPVGAAARTVLAHVGVVLWRTGEDRFRLLVRRSFADYLWHW 159


                 ....*....
gi 240860233 173 LNEAAEDAG 181
Cdd:COG4583  160 LEDAAREYG 168
soxG TIGR01375
sarcosine oxidase, gamma subunit family, heterotetrameric form; This model describes the gamma ...
 34-179 5.99e-49

sarcosine oxidase, gamma subunit family, heterotetrameric form; This model describes the gamma subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Mesorhizobium loti and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members are share the same function. The model is designated as subfamily rather than equivalog for this reason. The gamma subunit is the most divergent between operons of the four subunits. Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273586 [Multi-domain]  Cd Length: 152  Bit Score: 155.74  E-value: 5.99e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240860233   34 LRAPAES--LSALSSALGLTLPDAPKTSGRAGARSALWIGPDEWLVIDEA--GAGLMAALSAAGT--LHSATDVSHRNVA 107
Cdd:TIGR01375   1 LRALPGGaiVAALAAALGLTLPARLGSVASGGEISVLWLGPDEWLIIAPQpeGAVLMAALAAALGpePHAVVDLSGGRTA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 240860233  108 IIVSGPGAEATLSGGCPQDLSLSSFPVGAASRTVFGKAEIVLFRTEEDTFRVECWRSFSDYVFGLLNEAAED 179
Cdd:TIGR01375  81 LRISGPMAEEVLAKGCAVDLSLSAFPVGAGRRTIFGKIAAVIWRTGEDTFEIIVRRSFAESLWHWLVDASEE 152
SoxG pfam04268
Sarcosine oxidase, gamma subunit family; Sarcosine oxidase is a hetero-tetrameric enzyme that ...
 42-178 1.19e-03

Sarcosine oxidase, gamma subunit family; Sarcosine oxidase is a hetero-tetrameric enzyme that contains both covalently bound FMN and non-covalently bound FAD and NAD(+). This enzyme catalyzes the oxidative demethylation of sarcosine to yield glycine, H2O2, and 5,10-CH2-tetrahydrofolate (H4folate) in a reaction requiring H4folate and O2.


Pssm-ID: 461245  Cd Length: 152  Bit Score: 37.81  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240860233   42 SALSSALGLTLPDApKTSGRAGARSALWIGPDEWLVI----DEAGAGLMAALSAAGTLHSATD-VSHRNVAIIVSGPGAE 116
Cdd:pfam04268  11 AAPGQAAELELHHA-ELHKAAGETAAKAGAPDEEKKIlgggEERADAADLAFAAAEELALALElPSAGQLLAEGEGALQR 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 240860233  117 ATLSGGCPQDLSLSSFPVGAASRTVFGKAEIVLFRTEEDTFRVECWRSFSDYVFGLLNEAAE 178
Cdd:pfam04268  90 EALDESLLIDPGGEEFAVEKALGQAFAEELCVARHNGEDGQELLELRGAADRELLMKQDASA 151
 
Name Accession Description Interval E-value
SoxG COG4583
Sarcosine oxidase gamma subunit [Amino acid transport and metabolism];
20-181 4.64e-50

Sarcosine oxidase gamma subunit [Amino acid transport and metabolism];


Pssm-ID: 443640  Cd Length: 169  Bit Score: 158.88  E-value: 4.64e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240860233  20 AVRLTTAPTASRVALRAPAES---LSALSSALGLTLPDAPKTSGrAGARSALWIGPDEWLVIDEAGAG--LMAALSAA-- 92
Cdd:COG4583    1 GVTLREVPPLGLVSLRARPGQealAAALKAALGLALPAPPRVAA-AGGRAALWLGPDEWLLLAPYGAAedLAAALAAAla 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240860233  93 GTLHSATDVSHRNVAIIVSGPGAEATLSGGCPQDLSLSSFPVGAASRTVFGKAEIVLFRTEEDTFRVECWRSFSDYVFGL 172
Cdd:COG4583   80 GLHAAVVDVSDGRTVFELSGPRARDVLAKLCPLDLHPRAFPVGAAARTVLAHVGVVLWRTGEDRFRLLVRRSFADYLWHW 159


                 ....*....
gi 240860233 173 LNEAAEDAG 181
Cdd:COG4583  160 LEDAAREYG 168
soxG TIGR01375
sarcosine oxidase, gamma subunit family, heterotetrameric form; This model describes the gamma ...
 34-179 5.99e-49

sarcosine oxidase, gamma subunit family, heterotetrameric form; This model describes the gamma subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Mesorhizobium loti and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members are share the same function. The model is designated as subfamily rather than equivalog for this reason. The gamma subunit is the most divergent between operons of the four subunits. Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273586 [Multi-domain]  Cd Length: 152  Bit Score: 155.74  E-value: 5.99e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240860233   34 LRAPAES--LSALSSALGLTLPDAPKTSGRAGARSALWIGPDEWLVIDEA--GAGLMAALSAAGT--LHSATDVSHRNVA 107
Cdd:TIGR01375   1 LRALPGGaiVAALAAALGLTLPARLGSVASGGEISVLWLGPDEWLIIAPQpeGAVLMAALAAALGpePHAVVDLSGGRTA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 240860233  108 IIVSGPGAEATLSGGCPQDLSLSSFPVGAASRTVFGKAEIVLFRTEEDTFRVECWRSFSDYVFGLLNEAAED 179
Cdd:TIGR01375  81 LRISGPMAEEVLAKGCAVDLSLSAFPVGAGRRTIFGKIAAVIWRTGEDTFEIIVRRSFAESLWHWLVDASEE 152
SoxG pfam04268
Sarcosine oxidase, gamma subunit family; Sarcosine oxidase is a hetero-tetrameric enzyme that ...
 42-178 1.19e-03

Sarcosine oxidase, gamma subunit family; Sarcosine oxidase is a hetero-tetrameric enzyme that contains both covalently bound FMN and non-covalently bound FAD and NAD(+). This enzyme catalyzes the oxidative demethylation of sarcosine to yield glycine, H2O2, and 5,10-CH2-tetrahydrofolate (H4folate) in a reaction requiring H4folate and O2.


Pssm-ID: 461245  Cd Length: 152  Bit Score: 37.81  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240860233   42 SALSSALGLTLPDApKTSGRAGARSALWIGPDEWLVI----DEAGAGLMAALSAAGTLHSATD-VSHRNVAIIVSGPGAE 116
Cdd:pfam04268  11 AAPGQAAELELHHA-ELHKAAGETAAKAGAPDEEKKIlgggEERADAADLAFAAAEELALALElPSAGQLLAEGEGALQR 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 240860233  117 ATLSGGCPQDLSLSSFPVGAASRTVFGKAEIVLFRTEEDTFRVECWRSFSDYVFGLLNEAAE 178
Cdd:pfam04268  90 EALDESLLIDPGGEEFAVEKALGQAFAEELCVARHNGEDGQELLELRGAADRELLMKQDASA 151
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 100-179 1.82e-03

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 37.57  E-value: 1.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240860233  100 DVSHRNVaIIVSGPGAEATLSGGCPQDlsLSSFPVGAASRTVF----G--KAEIVLFRTEEDTFRVECWRSFSDYVFGLL 173
Cdd:pfam01571  43 DVSHMGK-IEVSGPDAAAFLQRLTTND--VSKLKPGRATYTLMlnerGgvIDDLTVYRLGDDHFLLVVNAANREKDLAWL 119


                  ....*.
gi 240860233  174 NEAAED 179
Cdd:pfam01571 120 RKHAEK 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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