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Conserved domains on  [gi|240281950|gb|EER45453|]
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G-protein complex beta subunit CpcB [Histoplasma capsulatum H143]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-70 6.49e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 6.49e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 240281950   7 HRGTLEGHNGWVTSLATSlENPDMLLSASRDKTLIIWNLTRDDtaygyPKRSLHGHSHIVSDCV 70
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVA 58
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-70 6.49e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 6.49e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 240281950   7 HRGTLEGHNGWVTSLATSlENPDMLLSASRDKTLIIWNLTRDDtaygyPKRSLHGHSHIVSDCV 70
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVA 58
WD40 COG2319
WD40 repeat [General function prediction only];
10-70 5.97e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 5.97e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 240281950  10 TLEGHNGWVTSLATSlenPD--MLLSASRDKTLIIWNLTRddtayGYPKRSLHGHSHIVSDCV 70
Cdd:COG2319  199 TLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLAT-----GKLLRTLTGHSGSVRSVA 253
WD40 pfam00400
WD domain, G-beta repeat;
9-44 1.04e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.04e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 240281950   9 GTLEGHNGWVTSLATSlENPDMLLSASRDKTLIIWN 44
Cdd:pfam00400  5 KTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 10-44 1.58e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 1.58e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 240281950   10 TLEGHNGWVTSLATSlENPDMLLSASRDKTLIIWN 44
Cdd:smart00320  7 TLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-70 6.49e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 6.49e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 240281950   7 HRGTLEGHNGWVTSLATSlENPDMLLSASRDKTLIIWNLTRDDtaygyPKRSLHGHSHIVSDCV 70
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVA 58
WD40 COG2319
WD40 repeat [General function prediction only];
10-70 5.97e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 5.97e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 240281950  10 TLEGHNGWVTSLATSlenPD--MLLSASRDKTLIIWNLTRddtayGYPKRSLHGHSHIVSDCV 70
Cdd:COG2319  199 TLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLAT-----GKLLRTLTGHSGSVRSVA 253
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-69 7.27e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 7.27e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 240281950  10 TLEGHNGWVTSLATSlENPDMLLSASRDKTLIIWnltrdDTAYGYPKRSLHGHSHIVSDC 69
Cdd:cd00200  130 TLRGHTDWVNSVAFS-PDGTFVASSSQDGTIKLW-----DLRTGKCVATLTGHTGEVNSV 183
WD40 COG2319
WD40 repeat [General function prediction only];
10-68 7.55e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 7.55e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 240281950  10 TLEGHNGWVTSLATSlenPD--MLLSASRDKTLIIWNLTRddtayGYPKRSLHGHSHIVSD 68
Cdd:COG2319  157 TLTGHSGAVTSVAFS---PDgkLLASGSDDGTVRLWDLAT-----GKLLRTLTGHTGAVRS 209
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-67 7.94e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 7.94e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 240281950   9 GTLEGHNGWVTSLATSlENPDMLLSASRDKTLIIWnltrdDTAYGYPKRSLHGHSHIVS 67
Cdd:cd00200  213 GTLRGHENGVNSVAFS-PDGYLLASGSEDGTIRVW-----DLRTGECVQTLSGHTNSVT 265
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-69 1.29e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 1.29e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 240281950  10 TLEGHNGWVTSLAtSLENPDMLLSASRDKTLIIWnltrdDTAYGYPKRSLHGHSHIVSDC 69
Cdd:cd00200   88 TLTGHTSYVSSVA-FSPDGRILSSSSRDKTIKVW-----DVETGKCLTTLRGHTDWVNSV 141
WD40 COG2319
WD40 repeat [General function prediction only];
10-67 1.92e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 1.92e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 240281950  10 TLEGHNGWVTSLATSlenPD--MLLSASRDKTLIIWNLTRddtayGYPKRSLHGHSHIVS 67
Cdd:COG2319  241 TLTGHSGSVRSVAFS---PDgrLLASGSADGTVRLWDLAT-----GELLRTLTGHSGGVN 292
WD40 COG2319
WD40 repeat [General function prediction only];
10-66 5.16e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 5.16e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 240281950  10 TLEGHNGWVTSLATSlenPD--MLLSASRDKTLIIWNLTRddtayGYPKRSLHGHSHIV 66
Cdd:COG2319  283 TLTGHSGGVNSVAFS---PDgkLLASGSDDGTVRLWDLAT-----GKLLRTLTGHTGAV 333
WD40 COG2319
WD40 repeat [General function prediction only];
7-68 1.07e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 1.07e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 240281950   7 HRGTLEGHNGWVTSLATSlenPD--MLLSASRDKTLIIWNLTRddtayGYPKRSLHGHSHIVSD 68
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFS---PDgkTLASGSADGTVRLWDLAT-----GKLLRTLTGHSGAVTS 167
WD40 COG2319
WD40 repeat [General function prediction only];
10-68 1.61e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 1.61e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 240281950  10 TLEGHNGWVTSLATSlenPD--MLLSASRDKTLIIWNLTRddtayGYPKRSLHGHSHIVSD 68
Cdd:COG2319  325 TLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLAT-----GELLRTLTGHTGAVTS 377
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-70 2.40e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 2.40e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 240281950  10 TLEGHNGWVTSLATSlENPDMLLSASRDKTLIIWNLTRDDTaygypKRSLHGHSHIVSDCV 70
Cdd:cd00200  172 TLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKC-----LGTLRGHENGVNSVA 226
WD40 COG2319
WD40 repeat [General function prediction only];
9-46 2.65e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 2.65e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 240281950   9 GTLEGHNGWVTSLATSlenPD--MLLSASRDKTLIIWNLT 46
Cdd:COG2319  366 RTLTGHTGAVTSVAFS---PDgrTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-69 5.38e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 5.38e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 240281950  10 TLEGHNGWVTSLATSLENpDMLLSASRDKTLIIWNLTRddtayGYPKRSLHGHSHIVSDC 69
Cdd:cd00200   46 TLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLET-----GECVRTLTGHTSYVSSV 99
WD40 pfam00400
WD domain, G-beta repeat;
9-44 1.04e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.04e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 240281950   9 GTLEGHNGWVTSLATSlENPDMLLSASRDKTLIIWN 44
Cdd:pfam00400  5 KTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 10-44 1.58e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 1.58e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 240281950   10 TLEGHNGWVTSLATSlENPDMLLSASRDKTLIIWN 44
Cdd:smart00320  7 TLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-44 1.31e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 35.00  E-value: 1.31e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 240281950   9 GTLEGHNGWVTSLATSlENPDMLLSASRDKTLIIWN 44
Cdd:cd00200  255 QTLSGHTNSVTSLAWS-PDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-67 6.20e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 32.96  E-value: 6.20e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 240281950   8 RGTLEGHNGWVTSLATSLeNPDMLLSASRDKTLIIWNLTRddtayGYPKRSLHGHSHIVS 67
Cdd:COG2319   71 LATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLAT-----GLLLRTLTGHTGAVR 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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