NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|240254318|ref|NP_176659|]
View 

ILITYHIA [Arabidopsis thaliana]

Protein Classification

U-box domain-containing protein( domain architecture ID 12145868)

U-box domain-containing protein contains a modified RING finger and functions as an E3 ubiquitin ligase that mediates the ubiquitination of target proteins by bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HSH155 super family cl26678
U2 snRNP spliceosome subunit [RNA processing and modification];
1861-2526 3.44e-11

U2 snRNP spliceosome subunit [RNA processing and modification];


The actual alignment was detected with superfamily member COG5181:

Pssm-ID: 227508 [Multi-domain]  Cd Length: 975  Bit Score: 69.21  E-value: 3.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1861 LKEIMPILMStlissLASPSSERRQVAG------RSLGELVRKLGERVLPLIIPILSkglkDPDVDKRqgvCIGLNEVMA 1934
Cdd:COG5181   205 FNKVLPMLMS-----RELEDQERHLVVKlidrllYGLDDLKVPYVHKILVVVGPLLI----DEDLKRR---CMGREIILN 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1935 SAGRSQLlSFMdqlIPTIRTALCDSALEVRESAGLAFSTLYKSAGLQAMDEIIPTLLEALEDDEMSTTALDGLKQIISVR 2014
Cdd:COG5181   273 LVYRCGL-GFS---VSSMRPDITSKDEYVRNVTGRAVGVVADALGVEELLPFLEALCGSRKSWEARHTGIRIAQQICELL 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2015 TAAVLPH------ILPKLV---HLPLSALNAHALGALAEVAG---------------AGFNTHLGTILPALLSAMGGENK 2070
Cdd:COG5181   349 GRSRLSHlgpllkCISKLLkdrSRFVRIDTANALSYLAELVGpygieqfdevlcplwEGASQHRGKELVSFLKAMGFIIP 428

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2071 EVQ-ELAQEAAERVVLVI-------DEEGVETLLseLLKGVSDSQASI-------------------RRSSAYLIGY--- 2120
Cdd:COG5181   429 LMSpEYACHDTREHMEIVfrefkspDEEMKKDLL--VVERICDKVGTDtpwklrdqvspeffspfwrRRSAGDRRSYkqv 506

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2121 FFKSSKLYLIDEAPNMISTLIVMLSDSDSTTVAVSWEALARVIGSVPK-EVLPSYIKLVRDAVSTA------RDKERRKR 2193
Cdd:COG5181   507 VLTTVILAKMGGDPRVSRKILEYYSDEPEPYRKMNAGLVSRIFSRLGRlGFDERLEERLYDSILNAfqeqdtTVGLILPC 586

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2194 KGGYVVIPGLCLPKSLKPLLPVFLQGLISGSAELREQAAIGLGELIEVTSEQALKEFVIPITGPLIRIIGDRFPWQVKSA 2273
Cdd:COG5181   587 FSTVLVSLEFRGKPHLSMIVSTILKLLRSKPPDVRIRAADLMGSLAKVLKACGETKELAKLGNILYENLGEDYPEVLGSI 666

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2274 ILATLIILIQRGGMALKPFLPQLQTTFVKCLQDSTRTIRSSAAVALGKLSALS-TRIDP-----LVGDLMTSFQAADSGV 2347
Cdd:COG5181   667 LKAICSIYSVHRFRSMQPPISGILPSLTPILRNKHQKVVANTIALVGTICMNSpEYIGVrewmrICFELVDSLKSWNKEI 746

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2348 REAILSAMrGVIkhaGKSIGPAvrvRIFDLLKDLMHHEDDQVRISATSMLGVLSQYleAAQLSVLLQEVNDLSaSQNWGA 2427
Cdd:COG5181   747 RRNATETF-GCI---SRAIGPQ---DVLDILLNNLKVQERQQRVCTSVAISIVAEY--CGPFSVLPTLMSDYE-TPEANV 816

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2428 RHGSVLCISSLLK--HNpstiMTSSLFSSMLNSLKSSLKDekfplRESSTKALGRLLLKQLATDPSNTKVV---IDVLSS 2502
Cdd:COG5181   817 QNGVLKAMCFMFEyiGQ----ASLDYVYSITPLLEDALTD-----RDPVHRQTAMNVIRHLVLNCPGTGDEdaaIHLLNL 887

                         730       740
                  ....*....|....*....|....
gi 240254318 2503 IVSALHDDSSEVRRRALSSLKAFA 2526
Cdd:COG5181   888 LWPNILEPSPHVIQSFDEGMESFA 911
HEAT COG1413
HEAT repeat [General function prediction only];
1617-1784 2.31e-06

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 49.24  E-value: 2.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1617 VRSVAARAVGSLirgmGEdnfPDLVPWLFETLKSDTSNVeRYGAAQglseviaALGTDYFENILPDLIRHCSHQKASVRD 1696
Cdd:COG1413     1 VRRAAARALGRL----GD---PAAVPALIAALADEDPDV-RAAAAR-------ALGRLGDPRAVPALLEALKDPDPEVRA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1697 GYLtlfkflpRSLGAQFQKylqLVLPAILDGLADENESVRDAALGAghvLVEHHATTSLPLLLPAVEDgifnDNWRIRQS 1776
Cdd:COG1413    66 AAA-------EALGRIGDP---EAVPALIAALKDEDPEVRRAAAEA---LGRLGDPAAVPALLEALKD----PDWEVRRA 128


                  ....*...
gi 240254318 1777 SVELLGDL 1784
Cdd:COG1413   129 AARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
1432-1538 5.66e-04

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 5.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1432 QLSAYGVKLVLPSLLKGLEDKAWRTKQSSVQLLGAMAfcapqqlsqcLPRVVPKLTEVLTDTHPKVQSAGQLALqqvgSV 1511
Cdd:COG1413     8 ALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLG----------DPRAVPALLEALKDPDPEVRAAAAEAL----GR 73

                          90       100
                  ....*....|....*....|....*..
gi 240254318 1512 IKNPEIsslVPTLLLALTDPNEYTRHA 1538
Cdd:COG1413    74 IGDPEA---VPALIAALKDEDPEVRRA 97
 
Name Accession Description Interval E-value
HSH155 COG5181
U2 snRNP spliceosome subunit [RNA processing and modification];
1861-2526 3.44e-11

U2 snRNP spliceosome subunit [RNA processing and modification];


Pssm-ID: 227508 [Multi-domain]  Cd Length: 975  Bit Score: 69.21  E-value: 3.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1861 LKEIMPILMStlissLASPSSERRQVAG------RSLGELVRKLGERVLPLIIPILSkglkDPDVDKRqgvCIGLNEVMA 1934
Cdd:COG5181   205 FNKVLPMLMS-----RELEDQERHLVVKlidrllYGLDDLKVPYVHKILVVVGPLLI----DEDLKRR---CMGREIILN 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1935 SAGRSQLlSFMdqlIPTIRTALCDSALEVRESAGLAFSTLYKSAGLQAMDEIIPTLLEALEDDEMSTTALDGLKQIISVR 2014
Cdd:COG5181   273 LVYRCGL-GFS---VSSMRPDITSKDEYVRNVTGRAVGVVADALGVEELLPFLEALCGSRKSWEARHTGIRIAQQICELL 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2015 TAAVLPH------ILPKLV---HLPLSALNAHALGALAEVAG---------------AGFNTHLGTILPALLSAMGGENK 2070
Cdd:COG5181   349 GRSRLSHlgpllkCISKLLkdrSRFVRIDTANALSYLAELVGpygieqfdevlcplwEGASQHRGKELVSFLKAMGFIIP 428

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2071 EVQ-ELAQEAAERVVLVI-------DEEGVETLLseLLKGVSDSQASI-------------------RRSSAYLIGY--- 2120
Cdd:COG5181   429 LMSpEYACHDTREHMEIVfrefkspDEEMKKDLL--VVERICDKVGTDtpwklrdqvspeffspfwrRRSAGDRRSYkqv 506

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2121 FFKSSKLYLIDEAPNMISTLIVMLSDSDSTTVAVSWEALARVIGSVPK-EVLPSYIKLVRDAVSTA------RDKERRKR 2193
Cdd:COG5181   507 VLTTVILAKMGGDPRVSRKILEYYSDEPEPYRKMNAGLVSRIFSRLGRlGFDERLEERLYDSILNAfqeqdtTVGLILPC 586

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2194 KGGYVVIPGLCLPKSLKPLLPVFLQGLISGSAELREQAAIGLGELIEVTSEQALKEFVIPITGPLIRIIGDRFPWQVKSA 2273
Cdd:COG5181   587 FSTVLVSLEFRGKPHLSMIVSTILKLLRSKPPDVRIRAADLMGSLAKVLKACGETKELAKLGNILYENLGEDYPEVLGSI 666

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2274 ILATLIILIQRGGMALKPFLPQLQTTFVKCLQDSTRTIRSSAAVALGKLSALS-TRIDP-----LVGDLMTSFQAADSGV 2347
Cdd:COG5181   667 LKAICSIYSVHRFRSMQPPISGILPSLTPILRNKHQKVVANTIALVGTICMNSpEYIGVrewmrICFELVDSLKSWNKEI 746

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2348 REAILSAMrGVIkhaGKSIGPAvrvRIFDLLKDLMHHEDDQVRISATSMLGVLSQYleAAQLSVLLQEVNDLSaSQNWGA 2427
Cdd:COG5181   747 RRNATETF-GCI---SRAIGPQ---DVLDILLNNLKVQERQQRVCTSVAISIVAEY--CGPFSVLPTLMSDYE-TPEANV 816

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2428 RHGSVLCISSLLK--HNpstiMTSSLFSSMLNSLKSSLKDekfplRESSTKALGRLLLKQLATDPSNTKVV---IDVLSS 2502
Cdd:COG5181   817 QNGVLKAMCFMFEyiGQ----ASLDYVYSITPLLEDALTD-----RDPVHRQTAMNVIRHLVLNCPGTGDEdaaIHLLNL 887

                         730       740
                  ....*....|....*....|....
gi 240254318 2503 IVSALHDDSSEVRRRALSSLKAFA 2526
Cdd:COG5181   888 LWPNILEPSPHVIQSFDEGMESFA 911
HEAT COG1413
HEAT repeat [General function prediction only];
1617-1784 2.31e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 49.24  E-value: 2.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1617 VRSVAARAVGSLirgmGEdnfPDLVPWLFETLKSDTSNVeRYGAAQglseviaALGTDYFENILPDLIRHCSHQKASVRD 1696
Cdd:COG1413     1 VRRAAARALGRL----GD---PAAVPALIAALADEDPDV-RAAAAR-------ALGRLGDPRAVPALLEALKDPDPEVRA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1697 GYLtlfkflpRSLGAQFQKylqLVLPAILDGLADENESVRDAALGAghvLVEHHATTSLPLLLPAVEDgifnDNWRIRQS 1776
Cdd:COG1413    66 AAA-------EALGRIGDP---EAVPALIAALKDEDPEVRRAAAEA---LGRLGDPAAVPALLEALKD----PDWEVRRA 128


                  ....*...
gi 240254318 1777 SVELLGDL 1784
Cdd:COG1413   129 AARALGRL 136
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 2268-2322 3.72e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 40.43  E-value: 3.72e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 240254318  2268 WQVKSAILATLIILIQRGGMALKPFLPQLQTTFVKCLQDSTRTIRSSAAVALGKL 2322
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
1432-1538 5.66e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 5.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1432 QLSAYGVKLVLPSLLKGLEDKAWRTKQSSVQLLGAMAfcapqqlsqcLPRVVPKLTEVLTDTHPKVQSAGQLALqqvgSV 1511
Cdd:COG1413     8 ALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLG----------DPRAVPALLEALKDPDPEVRAAAAEAL----GR 73

                          90       100
                  ....*....|....*....|....*..
gi 240254318 1512 IKNPEIsslVPTLLLALTDPNEYTRHA 1538
Cdd:COG1413    74 IGDPEA---VPALIAALKDEDPEVRRA 97
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
1722-1972 1.33e-03

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 44.07  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1722 PAILDGLADENESVRDAALGAGHVLVEhhaTTSLPlllPAVEDGIFNDNWRIRQSSVELLGDLLfkvAGTSGKALLEGGS 1801
Cdd:PRK13800  655 PALVAALGDGAAAVRRAAAEGLRELVE---VLPPA---PALRDHLGSPDPVVRAAALDVLRALR---AGDAALFAAALGD 725

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1802 DDEGASTEAQgRAIIDIlgmDKRNEVLAAlymvRTDVSLSVRQAALHVWKTIVANTPKTLkeimpilmSTLISSLASPSS 1881
Cdd:PRK13800  726 PDHRVRIEAV-RALVSV---DDVESVAGA----ATDENREVRIAVAKGLATLGAGGAPAG--------DAVRALTGDPDP 789

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1882 ERRQVAGRSLGELvrklgeRVLPLIIPILSKGLKDPDVDKRQGVCIGLNEVMASAGrsqllsfmdqlIPTIRTALCDSAL 1961
Cdd:PRK13800  790 LVRAAALAALAEL------GCPPDDVAAATAALRASAWQVRQGAARALAGAAADVA-----------VPALVEALTDPHL 852

                         250
                  ....*....|.
gi 240254318 1962 EVRESAGLAFS 1972
Cdd:PRK13800  853 DVRKAAVLALT 863
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 1454-1508 1.45e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 1.45e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 240254318  1454 WRTKQSSVQLLGAMAFCAPQQLSQCLPRVVPKLTEVLTDTHPKVQSAGQLALQQV 1508
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Name Accession Description Interval E-value
HSH155 COG5181
U2 snRNP spliceosome subunit [RNA processing and modification];
1861-2526 3.44e-11

U2 snRNP spliceosome subunit [RNA processing and modification];


Pssm-ID: 227508 [Multi-domain]  Cd Length: 975  Bit Score: 69.21  E-value: 3.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1861 LKEIMPILMStlissLASPSSERRQVAG------RSLGELVRKLGERVLPLIIPILSkglkDPDVDKRqgvCIGLNEVMA 1934
Cdd:COG5181   205 FNKVLPMLMS-----RELEDQERHLVVKlidrllYGLDDLKVPYVHKILVVVGPLLI----DEDLKRR---CMGREIILN 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1935 SAGRSQLlSFMdqlIPTIRTALCDSALEVRESAGLAFSTLYKSAGLQAMDEIIPTLLEALEDDEMSTTALDGLKQIISVR 2014
Cdd:COG5181   273 LVYRCGL-GFS---VSSMRPDITSKDEYVRNVTGRAVGVVADALGVEELLPFLEALCGSRKSWEARHTGIRIAQQICELL 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2015 TAAVLPH------ILPKLV---HLPLSALNAHALGALAEVAG---------------AGFNTHLGTILPALLSAMGGENK 2070
Cdd:COG5181   349 GRSRLSHlgpllkCISKLLkdrSRFVRIDTANALSYLAELVGpygieqfdevlcplwEGASQHRGKELVSFLKAMGFIIP 428

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2071 EVQ-ELAQEAAERVVLVI-------DEEGVETLLseLLKGVSDSQASI-------------------RRSSAYLIGY--- 2120
Cdd:COG5181   429 LMSpEYACHDTREHMEIVfrefkspDEEMKKDLL--VVERICDKVGTDtpwklrdqvspeffspfwrRRSAGDRRSYkqv 506

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2121 FFKSSKLYLIDEAPNMISTLIVMLSDSDSTTVAVSWEALARVIGSVPK-EVLPSYIKLVRDAVSTA------RDKERRKR 2193
Cdd:COG5181   507 VLTTVILAKMGGDPRVSRKILEYYSDEPEPYRKMNAGLVSRIFSRLGRlGFDERLEERLYDSILNAfqeqdtTVGLILPC 586

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2194 KGGYVVIPGLCLPKSLKPLLPVFLQGLISGSAELREQAAIGLGELIEVTSEQALKEFVIPITGPLIRIIGDRFPWQVKSA 2273
Cdd:COG5181   587 FSTVLVSLEFRGKPHLSMIVSTILKLLRSKPPDVRIRAADLMGSLAKVLKACGETKELAKLGNILYENLGEDYPEVLGSI 666

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2274 ILATLIILIQRGGMALKPFLPQLQTTFVKCLQDSTRTIRSSAAVALGKLSALS-TRIDP-----LVGDLMTSFQAADSGV 2347
Cdd:COG5181   667 LKAICSIYSVHRFRSMQPPISGILPSLTPILRNKHQKVVANTIALVGTICMNSpEYIGVrewmrICFELVDSLKSWNKEI 746

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2348 REAILSAMrGVIkhaGKSIGPAvrvRIFDLLKDLMHHEDDQVRISATSMLGVLSQYleAAQLSVLLQEVNDLSaSQNWGA 2427
Cdd:COG5181   747 RRNATETF-GCI---SRAIGPQ---DVLDILLNNLKVQERQQRVCTSVAISIVAEY--CGPFSVLPTLMSDYE-TPEANV 816

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2428 RHGSVLCISSLLK--HNpstiMTSSLFSSMLNSLKSSLKDekfplRESSTKALGRLLLKQLATDPSNTKVV---IDVLSS 2502
Cdd:COG5181   817 QNGVLKAMCFMFEyiGQ----ASLDYVYSITPLLEDALTD-----RDPVHRQTAMNVIRHLVLNCPGTGDEdaaIHLLNL 887

                         730       740
                  ....*....|....*....|....
gi 240254318 2503 IVSALHDDSSEVRRRALSSLKAFA 2526
Cdd:COG5181   888 LWPNILEPSPHVIQSFDEGMESFA 911
HEAT COG1413
HEAT repeat [General function prediction only];
1617-1784 2.31e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 49.24  E-value: 2.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1617 VRSVAARAVGSLirgmGEdnfPDLVPWLFETLKSDTSNVeRYGAAQglseviaALGTDYFENILPDLIRHCSHQKASVRD 1696
Cdd:COG1413     1 VRRAAARALGRL----GD---PAAVPALIAALADEDPDV-RAAAAR-------ALGRLGDPRAVPALLEALKDPDPEVRA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1697 GYLtlfkflpRSLGAQFQKylqLVLPAILDGLADENESVRDAALGAghvLVEHHATTSLPLLLPAVEDgifnDNWRIRQS 1776
Cdd:COG1413    66 AAA-------EALGRIGDP---EAVPALIAALKDEDPEVRRAAAEA---LGRLGDPAAVPALLEALKD----PDWEVRRA 128


                  ....*...
gi 240254318 1777 SVELLGDL 1784
Cdd:COG1413   129 AARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
2299-2418 3.54e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.78  E-value: 3.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2299 TFVKCLQDSTRTIRSSAAVALGKLSAlstriDPLVGDLMTSFQAADSGVREAILSAMRgvikhagkSIGPAvrvRIFDLL 2378
Cdd:COG1413    20 ALIAALADEDPDVRAAAARALGRLGD-----PRAVPALLEALKDPDPEVRAAAAEALG--------RIGDP---EAVPAL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 240254318 2379 KDLMHHEDDQVRISATSMLGVLSqylEAAQLSVLLQEVND 2418
Cdd:COG1413    84 IAALKDEDPEVRRAAAEALGRLG---DPAAVPALLEALKD 120
HEAT COG1413
HEAT repeat [General function prediction only];
2459-2559 2.35e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.46  E-value: 2.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2459 LKSSLKDEKFPLRESSTKALGRL-------LLKQLATDPSNT--KVVIDVLSSI---------VSALHDDSSEVRRRALS 2520
Cdd:COG1413    21 LIAALADEDPDVRAAAARALGRLgdpravpALLEALKDPDPEvrAAAAEALGRIgdpeavpalIAALKDEDPEVRRAAAE 100

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 240254318 2521 SLKAFakDNPSATmanisvigPPLAECLKDGNTPVRLAA 2559
Cdd:COG1413   101 ALGRL--GDPAAV--------PALLEALKDPDWEVRRAA 129
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 2268-2322 3.72e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 40.43  E-value: 3.72e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 240254318  2268 WQVKSAILATLIILIQRGGMALKPFLPQLQTTFVKCLQDSTRTIRSSAAVALGKL 2322
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
1432-1538 5.66e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 5.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1432 QLSAYGVKLVLPSLLKGLEDKAWRTKQSSVQLLGAMAfcapqqlsqcLPRVVPKLTEVLTDTHPKVQSAGQLALqqvgSV 1511
Cdd:COG1413     8 ALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLG----------DPRAVPALLEALKDPDPEVRAAAAEAL----GR 73

                          90       100
                  ....*....|....*....|....*..
gi 240254318 1512 IKNPEIsslVPTLLLALTDPNEYTRHA 1538
Cdd:COG1413    74 IGDPEA---VPALIAALKDEDPEVRRA 97
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
1722-1972 1.33e-03

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 44.07  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1722 PAILDGLADENESVRDAALGAGHVLVEhhaTTSLPlllPAVEDGIFNDNWRIRQSSVELLGDLLfkvAGTSGKALLEGGS 1801
Cdd:PRK13800  655 PALVAALGDGAAAVRRAAAEGLRELVE---VLPPA---PALRDHLGSPDPVVRAAALDVLRALR---AGDAALFAAALGD 725

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1802 DDEGASTEAQgRAIIDIlgmDKRNEVLAAlymvRTDVSLSVRQAALHVWKTIVANTPKTLkeimpilmSTLISSLASPSS 1881
Cdd:PRK13800  726 PDHRVRIEAV-RALVSV---DDVESVAGA----ATDENREVRIAVAKGLATLGAGGAPAG--------DAVRALTGDPDP 789

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1882 ERRQVAGRSLGELvrklgeRVLPLIIPILSKGLKDPDVDKRQGVCIGLNEVMASAGrsqllsfmdqlIPTIRTALCDSAL 1961
Cdd:PRK13800  790 LVRAAALAALAEL------GCPPDDVAAATAALRASAWQVRQGAARALAGAAADVA-----------VPALVEALTDPHL 852

                         250
                  ....*....|.
gi 240254318 1962 EVRESAGLAFS 1972
Cdd:PRK13800  853 DVRKAAVLALT 863
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 1454-1508 1.45e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 1.45e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 240254318  1454 WRTKQSSVQLLGAMAFCAPQQLSQCLPRVVPKLTEVLTDTHPKVQSAGQLALQQV 1508
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
2376-2526 3.36e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 2376 DLLKDLMHHEDDQVRISATSMLGVLSqylEAAQLSVLLQEVNDlsasQNWGARHGSVLCISSLlkHNPSTImtsslfssm 2455
Cdd:COG1413    19 PALIAALADEDPDVRAAAARALGRLG---DPRAVPALLEALKD----PDPEVRAAAAEALGRI--GDPEAV--------- 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 240254318 2456 lNSLKSSLKDEKFPLRESSTKALGRLllkqlatdpsNTKVVIDVLssiVSALHDDSSEVRRRALSSLKAFA 2526
Cdd:COG1413    81 -PALIAALKDEDPEVRRAAAEALGRL----------GDPAAVPAL---LEALKDPDWEVRRAAARALGRLG 137
HEAT COG1413
HEAT repeat [General function prediction only];
1720-1894 6.49e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.23  E-value: 6.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1720 VLPAILDGLADENESVRDAALGAghvLVEHHATTSLPLLLPAVEDgifnDNWRIRQSSVELLGDLlfkvagtsgkalleg 1799
Cdd:COG1413    17 AVPALIAALADEDPDVRAAAARA---LGRLGDPRAVPALLEALKD----PDPEVRAAAAEALGRI--------------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254318 1800 gsddegasteaQGRAIIDILgmdkrnevLAALymvrTDVSLSVRQAALHvwktivantpkTLKEIM-PILMSTLISSLAS 1878
Cdd:COG1413    75 -----------GDPEAVPAL--------IAAL----KDEDPEVRRAAAE-----------ALGRLGdPAAVPALLEALKD 120

                         170
                  ....*....|....*.
gi 240254318 1879 PSSERRQVAGRSLGEL 1894
Cdd:COG1413   121 PDWEVRRAAARALGRL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH