TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376    8 SEDLVTSLLDTRLVHHNASKWETFDVTPAIMRWIAHEQPNLGFVVEVVHLNN-ASNVSKRHVRISrslHQDDasWSRIRP 86
Cdd:pfam00688 160 GGDASLRLLDSRLVTASEEGWLSFDVTEALNRWLANPEENLGLQLSVHCSCRsGREIKPDDVGLV---GRRG--WDQKQP 234

                  ....*
gi 238636376   87 LLVTF 91
Cdd:pfam00688 235 FLVTF 239

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 238636376   120 CKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQTLVHSVN-SKIPKACCVPTELSPISML 196
Cdd:smart00204   1 CRRRQLYVDFKDLGWDDWIIAPKGYNAYYCEGECPFPLSTSLNATNHAIVQTLVHLLGpNPVPKPCCVPTKLSPLSML 78

TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376    8 SEDLVTSLLDTRLVHHNASKWETFDVTPAIMRWIAHEQPNLGFVVEVVHLNN-ASNVSKRHVRISrslHQDDasWSRIRP 86
Cdd:pfam00688 160 GGDASLRLLDSRLVTASEEGWLSFDVTEALNRWLANPEENLGLQLSVHCSCRsGREIKPDDVGLV---GRRG--WDQKQP 234

                  ....*
gi 238636376   87 LLVTF 91
Cdd:pfam00688 235 FLVTF 239

DNRLRE domain; The DNRLRE domain, with a length of about 160 amino acids, appears typically in large, repetitive surface proteins of bacteria and archaea, sometimes repeated several times. It occurs, notably, three times in the C-terminal region of the enzyme disaggregatase from the archaeal species Methanosarcina mazei, each time with the motif DNRLRE, for which the domain is named. Archaeal proteins within this family are described particularly well by the currently more narrowly defined Pfam model, PF06848. Note that the catalytic region of disaggregatase, in the N-terminal portion of the protein, is modeled by a different HMM, PF08480.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238636376  24 NASKWETFDVTPAIMRWIAHEQPNLGFVVEvvhlnnASNVSKRHVRI-SRslhqdDASWSRIRPLLV 89
Cdd:NF033679 107 PDGGWVEIDVTDLVQAWVSGTYPNYGFLLK------ASDESNGWKSFySS-----EAGNASNRPYLV 162

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2), 4 (BMP-4) and similar proteins; The family includes BMP2 and BMP4 (also known as BMP2B), both of which induce cartilage and bone formation. BMP-2 stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP-4 acts in mesoderm induction, tooth development, limb formation and fracture repair.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 120 CKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQTLVHSVNS-KIPKACCVPTELSPISML*L 198
Cdd:cd13760    1 CRRHSLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNPgAVPKACCVPTELSPISMLYL 80

                 ..
gi 238636376 199 *E 200
Cdd:cd13760   81 DE 82

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster protein decapentaplegic (Dpp) and similar proteins; decapentaplegic (Dpp) and similar proteins Dpp, also termed as protein DPP-C, is required later in embryogenesis for dorsal closure and patterning of the hindgut. It also functions postembryonically as a long-range morphogen during imaginal disk development and is responsible for the progression of the morphogenetic furrow during eye development.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 113 RRRLKSNCKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQTLVHSVN-SKIPKACCVPTELS 191
Cdd:cd19392    1 RKGHQNLCRRHPLYVDFSDVGWDDWIVAPLGYDAYYCNGECPFPLADYLNATNHAVVQTLVNSVDpQAVPKACCVPTELS 80

                 ....*....
gi 238636376 192 PISML*L*E 200
Cdd:cd19392   81 SIAMLYVDE 89

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 238636376   120 CKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQTLVHSVN-SKIPKACCVPTELSPISML 196
Cdd:smart00204   1 CRRRQLYVDFKDLGWDDWIIAPKGYNAYYCEGECPFPLSTSLNATNHAIVQTLVHLLGpNPVPKPCCVPTKLSPLSML 78

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, BMP-9, BMP-10 and similar proteins; The family includes BMP9 (also known as GDF2) and BMP10. BMP-9 is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs). BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 118 SNCKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQTLVHSVN-SKIPKACCVPTELSPISML 196
Cdd:cd13767    1 NSCRRKPLYVNFADIGWDSWIIAPKGYEAYECSGKCFFPLADHLSPTKHAIIQTLVHSKSpEKVSRACCVPTKLEPISLL 80

                 ....
gi 238636376 197 *L*E 200
Cdd:cd13767   81 YIDE 84

Transforming growth factor beta like domain;

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238636376  119 NCKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQTLVHSVN-SKIPKACCVPTELSPISML 196
Cdd:pfam00019   1 ECRRHSLYVDFEDLGWDDWIIAPKGYNAYYCSGSCPSHLNPQLSATNHAILQSLLHSLKpANVPKPCCVPTKLSPLSVL 79

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins; BMP-7, also termed osteogenic protein 1 (OP-1), or eptotermin alfa, induces cartilage and bone formation. It may act as the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis and play a role in calcium regulation and bone homeostasis.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 116 LKSNCKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQTLVHSVN-SKIPKACCVPTELSPIS 194
Cdd:cd19397    2 QRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINpETVPKPCCAPTQLNAIS 81

                 ..
gi 238636376 195 ML 196
Cdd:cd19397   82 VL 83

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 (BMP-10) and similar proteins; BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 120 CKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQTLVHSVNS-KIPKACCVPTELSPISML*L 198
Cdd:cd19401    3 CKRSPLYVDFKEIGWDSWIIAPTGYEAYECRGVCYYPLTEHVTPTKHAIVQTLVHLKNPqKASKACCVPTKLDPISILYL 82

transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic protein (ADMP) and similar proteins; ADMP is a bone morphogenetic protein (BMP)-like transforming growth factor beta ligand, functions in the trunk organizer to antagonize head formation, thereby regulating organizer patterning. It negatively affects the formation of the organizer, although it is robustly expressed within the organizer itself. The organizer-promoting signal of ADMP is mediated by the activin A type I receptor, ACVR1 (also known as activin receptor-like kinase-2, ALK2).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238636376 120 CKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQTLVH--SVNSKIPKACCVPTELSPISML 196
Cdd:cd13765    3 CQRHELYVDFEEIGWSGWIISPKGYNAYHCKGSCPFPLGQNQKPTNHATVQSIVHalKLAKGVEMPCCVPDKLYSISLL 81

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3), growth/differentiation factor 10 (GDF10) and similar proteins; The family includes BMP-3 (also known as BMP-3A or osteogenin) and GDF10 (also known as BMP-3B). BMP-3 negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. GDF10 is a growth factor involved in osteogenesis and adipogenesis.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 120 CKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQTLVHSVN--SKIPKACCVPTELSPISML* 197
Cdd:cd13763    1 CSRRPLTVDFADIGWSDWIISPKSFDAYYCAGSCPFPLTKELRPSNHATIQSIVHAVGiqPGVPAPCCVPDKMSSLTLLY 80

                 ...
gi 238636376 198 L*E 200
Cdd:cd13763   81 FDE 83

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9), growth/differentiation factor 9B (GDF-9B) and similar proteins; The family includes GDF-9B (also known as BMP15) and GDF9. GDF-9B acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 120 CKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQTLVHS-VNSKIPKACCVPTELSPISML*L 198
Cdd:cd13762    3 CRRHRLRVRFRDLKWNGWIIAPTRYTANYCKGTCPRVLGQDLNPTNHAIVQNILHHlLDKSVPRPSCVPTELHPLSVLYY 82

                 ..
gi 238636376 199 *E 200
Cdd:cd13762   83 EE 84

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 (BMP-9) and similar proteins; BMP-9, also termed growth/differentiation factor 2 (GDF-2), is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 118 SNCKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQTLVHSVN-SKIPKACCVPTELSPISML 196
Cdd:cd19400    1 NHCRKTSLRVNFKDIGWDSWIIAPKEYDAYECKGGCYFPLTDDVTPTKHAIIQTLVHLKNpKKAGKACCVPTKLDPISVL 80

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3) and similar proteins; BMP-3, also termed BMP-3A, or osteogenin, negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 119 NCKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQTLVHSVN--SKIPKACCVPTELSPISML 196
Cdd:cd19393    7 NCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGvvPGIPEPCCVPEKMSSLSIL 86

                 ....
gi 238636376 197 *L*E 200
Cdd:cd19393   87 FFDE 90

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), E chain (INHBE) and similar proteins; The family includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 238636376 120 CKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPlADHMNSTNHAIVQTLVHSVNSKI-PKACCVPTELSPISML 196
Cdd:cd13752    1 CCRESFYVSFTDIGWDDWIIAPSGYYANYCKGSCSGS-SSPFRSHHTTILQKYLSKNKAKSeLTPCCTPTKMSPLSLL 77

transforming growth factor beta (TGF-beta) like domain found in mammalian growth/differentiation factor 15 (GDF-15) and similar proteins; GDF-15, also termed macrophage inhibitory cytokine 1 (MIC-1), or NSAID-activated gene 1 protein (NAG-1), or NSAID-regulated gene 1 protein (NRG-1), or placental TGF-beta, or placental bone morphogenetic protein, or prostate differentiation factor, regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238636376 119 NCKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPfplADHMNSTNHAIVQTLVHSVN-SKIPKACCVPTELSPISML 196
Cdd:cd19376    2 RCCRFSLRVSFKEIGWADWVLAPESYNAYYCDGSCP---HNYKPANMHAQIKSRLHRLNpGAVPAPCCVPSSYEPLTLL 77

transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), beta chain (INHB) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland. INHB includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238636376 120 CKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPL-ADHMNSTN-HAIVQTLVHSVnSKIPKACCVPTELSPISML 196
Cdd:cd19377    1 CCRVALFVSFEELGWNRWIIAPPGFNFHFCHGGCALHIvPDLSLPVPsAPPTPARPYSV-LPGAQPCCAPTKVTPLSVL 78

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins; INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 120 CKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLAD--------HMNSTNHAIVQTlvHSVNSKIpKACCVPTELS 191
Cdd:cd19404    3 CCKKQFYVSFKDIGWSDWIIAPSGYHANYCEGECPSHIAGtsgsslsfHSTVINHYRMRG--YSPFANL-KSCCVPTKLR 79

                 ....*
gi 238636376 192 PISML 196
Cdd:cd19404   80 AMSML 84

TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376    8 SEDLVTSLLDTRLVHHNASKWETFDVTPAIMRWIAHEQPNLGFVVEVVHLNN-ASNVSKRHVRISrslHQDDasWSRIRP 86
Cdd:pfam00688 160 GGDASLRLLDSRLVTASEEGWLSFDVTEALNRWLANPEENLGLQLSVHCSCRsGREIKPDDVGLV---GRRG--WDQKQP 234

                  ....*
gi 238636376   87 LLVTF 91
Cdd:pfam00688 235 FLVTF 239

transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), inhibin beta E chain (INHBE) and similar proteins; The family includes INHBC and INHBE. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 120 CKRHPLYVDFNDVGWNDWIVAPPGYGAFYCHGDCPFPLADH--MNSTNHAIVQTLVHSVNSKIP-KACCVPTELSPISML 196
Cdd:cd19406    1 CCRRDFYVDFKDIGWNDWIIKPEGYQMNYCMGQCPLHIAGSpgIAASFHTAVLNLVKANNIATAvHSCCVPTARRPLSLL 80

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 120 CKRhPLYVDF-NDVGWnDWIVAPPGYGAFYCHGDCPFPladhMNSTNHA--IVQTLVHSVNSKIPKACCVPTELSPISML 196
Cdd:cd13753    2 CLR-PLYINFrRDLGW-KWIHEPKGFNANYCAGACPYL----WSADTQHstVLQLYNRLNPVASAAPCCSPRELEPLTIL 75

transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer larva development regulatory growth factor DAF-7 and similar proteins; DAF-7, also termed abnormal dauer formation protein 7, may act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. It is involved in sensitivity to CO2 levels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 120 CKRHPLYVDFNDVGWNdWIVAPPGYGAFYCHGDCPfPLADHMNSTNHAIVQTLVHSVNSKIPKACCVPTELSPISML*L* 199
Cdd:cd19378    3 CCLYDLTIDFEEIGWN-FIIAPKKYNANMCRGDCK-SNHHHRPNSASILLNPITRSESKQEHGSCCHPTEYDPITVVYFN 80

                 .
gi 238636376 200 E 200
Cdd:cd19378   81 E 81

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins; TGF-beta-3 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 117 KSNCKRHPLYVDF-NDVGWNdWIVAPPGYGAFYCHGDCPFPLAdhmNSTNHAIVQTLVHSVNSKIPKA-CCVPTELSPIS 194
Cdd:cd19386    1 EENCCVRPLYIDFrQDLGWK-WVHEPKGYFANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASASpCCVPQDLEPLT 76

                 ..
gi 238636376 195 ML 196
Cdd:cd19386   77 IL 78

transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins; AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 120 CKRHPLYVDFNDvgwNDWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVqtLVHSVNSKIPKA---CCVPTELSPISML 196
Cdd:cd13757    2 CRLRELSVSLRS---EKFILSPKRYNINNCQGPCRFPLSDRPRYNNHAVL--LLKMQERGLPLQrapCCVPVAYEELLVV 76

                 ....
gi 238636376 197 *L*E 200
Cdd:cd13757   77 ELSD 80

transforming growth factor beta (TGF-beta) like domain found in left-right determination factor 1 (lefty-1), factor 2 (lefty-2) and similar proteins; Lefty-1, also termed left-right determination factor B, or protein lefty-B, is required for left-right axis determination as a regulator of Lefty-2 and NODAL. Lefty-2, also termed endometrial bleeding-associated factor, or left-right determination factor A, or protein lefty-A, or transforming growth factor beta-4 (TGF-beta-4), is required for left-right (L-R) asymmetry determination of organ systems in mammals. It may play a role in endometrial bleeding.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238636376 120 CKRHPLYVDFNDVGW-NDWIVAPPGYGAFYCHGDCPfpladhmNSTNHAIVQTLVHSVnskipkacCVPTELSPISML*L 198
Cdd:cd13758    2 CCRQEYYIDFRELTWtDYWIIEPPGYQAYECVGGCP-------QPPPPLAWPSLGHRQ--------CGVSESASLPMMYL 66

TGF-beta-like protein; Provisional

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238636376 116 LKSNCKRHPLYVDFN-DVGWNdWIVAPPGYGAFYCHGDCPFPLADHMNSTNHAIVQtlvHSVNSKIPKACCVPTELS 191
Cdd:PHA02913  73 IDAICCIRDFNIDFKaDMGMK-WILKPEGTHANLCIGICSISNHKKINLMYGTAFK---HHMPDNTIPFCCAPIKMK 145

DNRLRE domain; The DNRLRE domain, with a length of about 160 amino acids, appears typically in large, repetitive surface proteins of bacteria and archaea, sometimes repeated several times. It occurs, notably, three times in the C-terminal region of the enzyme disaggregatase from the archaeal species Methanosarcina mazei, each time with the motif DNRLRE, for which the domain is named. Archaeal proteins within this family are described particularly well by the currently more narrowly defined Pfam model, PF06848. Note that the catalytic region of disaggregatase, in the N-terminal portion of the protein, is modeled by a different HMM, PF08480.

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                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238636376  24 NASKWETFDVTPAIMRWIAHEQPNLGFVVEvvhlnnASNVSKRHVRI-SRslhqdDASWSRIRPLLV 89
Cdd:NF033679 107 PDGGWVEIDVTDLVQAWVSGTYPNYGFLLK------ASDESNGWKSFySS-----EAGNASNRPYLV 162