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Conserved domains on  [gi|238231421|ref|NP_001154185|]
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CMRF35-like molecule 9 isoform 2 precursor [Mus musculus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146027)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to polymeric immunoglobulin receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 19-121 4.44e-21

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 86.68  E-value: 4.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238231421  19 LKGPKEISGFEGDTVSLRCTYVEKMKEHRKYWCRQGGilvSRCGDIVyaNQDQEVTRGRMSIRDSPQELSMTVIMRDLTL 98
Cdd:cd05716    1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS---EGCQTLV--SSEGVVPGGRISLTDDPDNGVFTVTLNQLRK 75

                         90       100
                 ....*....|....*....|....
gi 238231421  99 KDSGKYWCGI-DRLGRDESFEVTL 121
Cdd:cd05716   76 EDAGWYWCGVgDDGDRGLTVQVKL 99
PLN02217 super family cl33436
probable pectinesterase/pectinesterase inhibitor
 105-245 3.70e-04

probable pectinesterase/pectinesterase inhibitor


The actual alignment was detected with superfamily member PLN02217:

Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 42.38  E-value: 3.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238231421 105 WCGIDRLGRDESFEVTLIVF------------PASPGLHP-TVVTAKQGKTGVKAPVFTEVAPawSTGTSQVPPGISPYA 171
Cdd:PLN02217 524 WPGIKKLSDEEILKFTPAQYiqgdawipgkgvPYIPGLFAgNPGSTNSTPTGSAASSNTTFSS--DSPSTVVAPSTSPPA 601

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238231421 172 ---GSSPhtATPARSAGTSQVPPgiSPYAGRSPHTATSPHagSSRPVVWLPLTTPQDSRAVASSVSkpsvSIPMVRM 245
Cdd:PLN02217 602 ghlGSPP--ATPSKIVSPSTSPP--ASHLGSPSTTPSSPE--SSIKVASTETASPESSIKVASTES----SVSMVSM 668
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 19-121 4.44e-21

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 86.68  E-value: 4.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238231421  19 LKGPKEISGFEGDTVSLRCTYVEKMKEHRKYWCRQGGilvSRCGDIVyaNQDQEVTRGRMSIRDSPQELSMTVIMRDLTL 98
Cdd:cd05716    1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS---EGCQTLV--SSEGVVPGGRISLTDDPDNGVFTVTLNQLRK 75

                         90       100
                 ....*....|....*....|....
gi 238231421  99 KDSGKYWCGI-DRLGRDESFEVTL 121
Cdd:cd05716   76 EDAGWYWCGVgDDGDRGLTVQVKL 99
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 21-123 7.55e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.32  E-value: 7.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238231421   21 GPKEISGFEGDTVSLRCTYVEKMKEH--RKYWCRQGGILVSRCGDIVYAN-QDQEVTRGRMSIRDSPQELSMTVIMRDLT 97
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEAstSVYWYRQPPGKGPTFLIAYYSNgSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*..
gi 238231421   98 LKDSGKYWCGI-DRLGRDESFEVTLIV 123
Cdd:pfam07686  82 LSDSGTYTCAViPSGEGVFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 22-123 1.05e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 51.74  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238231421    22 PKEISGFEGDTVSLRCTyVEKMKEHRKYWCRQGGILVSrcgdivyanqdqevTRGRMSIRDSPQELSMTviMRDLTLKDS 101
Cdd:smart00410   1 PPSVTVKEGESVTLSCE-ASGSPPPEVTWYKQGGKLLA--------------ESGRFSVSRSGSTSTLT--ISNVTPEDS 63

                           90       100
                   ....*....|....*....|..
gi 238231421   102 GKYWCGIDRLGRDESFEVTLIV 123
Cdd:smart00410  64 GTYTCAATNSSGSASSGTTLTV 85
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 105-245 3.70e-04

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 42.38  E-value: 3.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238231421 105 WCGIDRLGRDESFEVTLIVF------------PASPGLHP-TVVTAKQGKTGVKAPVFTEVAPawSTGTSQVPPGISPYA 171
Cdd:PLN02217 524 WPGIKKLSDEEILKFTPAQYiqgdawipgkgvPYIPGLFAgNPGSTNSTPTGSAASSNTTFSS--DSPSTVVAPSTSPPA 601

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238231421 172 ---GSSPhtATPARSAGTSQVPPgiSPYAGRSPHTATSPHagSSRPVVWLPLTTPQDSRAVASSVSkpsvSIPMVRM 245
Cdd:PLN02217 602 ghlGSPP--ATPSKIVSPSTSPP--ASHLGSPSTTPSSPE--SSIKVASTETASPESSIKVASTES----SVSMVSM 668
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 19-121 4.44e-21

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 86.68  E-value: 4.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238231421  19 LKGPKEISGFEGDTVSLRCTYVEKMKEHRKYWCRQGGilvSRCGDIVyaNQDQEVTRGRMSIRDSPQELSMTVIMRDLTL 98
Cdd:cd05716    1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS---EGCQTLV--SSEGVVPGGRISLTDDPDNGVFTVTLNQLRK 75

                         90       100
                 ....*....|....*....|....
gi 238231421  99 KDSGKYWCGI-DRLGRDESFEVTL 121
Cdd:cd05716   76 EDAGWYWCGVgDDGDRGLTVQVKL 99
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 21-123 7.55e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.32  E-value: 7.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238231421   21 GPKEISGFEGDTVSLRCTYVEKMKEH--RKYWCRQGGILVSRCGDIVYAN-QDQEVTRGRMSIRDSPQELSMTVIMRDLT 97
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEAstSVYWYRQPPGKGPTFLIAYYSNgSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*..
gi 238231421   98 LKDSGKYWCGI-DRLGRDESFEVTLIV 123
Cdd:pfam07686  82 LSDSGTYTCAViPSGEGVFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 22-123 1.05e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 51.74  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238231421    22 PKEISGFEGDTVSLRCTyVEKMKEHRKYWCRQGGILVSrcgdivyanqdqevTRGRMSIRDSPQELSMTviMRDLTLKDS 101
Cdd:smart00410   1 PPSVTVKEGESVTLSCE-ASGSPPPEVTWYKQGGKLLA--------------ESGRFSVSRSGSTSTLT--ISNVTPEDS 63

                           90       100
                   ....*....|....*....|..
gi 238231421   102 GKYWCGIDRLGRDESFEVTLIV 123
Cdd:smart00410  64 GTYTCAATNSSGSASSGTTLTV 85
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 105-245 3.70e-04

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 42.38  E-value: 3.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238231421 105 WCGIDRLGRDESFEVTLIVF------------PASPGLHP-TVVTAKQGKTGVKAPVFTEVAPawSTGTSQVPPGISPYA 171
Cdd:PLN02217 524 WPGIKKLSDEEILKFTPAQYiqgdawipgkgvPYIPGLFAgNPGSTNSTPTGSAASSNTTFSS--DSPSTVVAPSTSPPA 601

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238231421 172 ---GSSPhtATPARSAGTSQVPPgiSPYAGRSPHTATSPHagSSRPVVWLPLTTPQDSRAVASSVSkpsvSIPMVRM 245
Cdd:PLN02217 602 ghlGSPP--ATPSKIVSPSTSPP--ASHLGSPSTTPSSPE--SSIKVASTETASPESSIKVASTES----SVSMVSM 668
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 22-104 2.55e-03

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 37.37  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238231421  22 PKEISGFEGDTVSLRC--TYVEKMKEHRK---YWCRQGGILVSRcGDIVYANQDQEV---TRGRMSIRDSPQELSMTVIM 93
Cdd:cd05712    6 PKSVTVQEGLCVLIPCsfSYPADYWVSNPvhgYWYRGGPYPKYR-PPVATNNRTREVhesTQGRFRLLGDPGKKNCSLSI 84

                         90
                 ....*....|.
gi 238231421  94 RDLTLKDSGKY 104
Cdd:cd05712   85 SDARPEDSGKY 95
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 22-106 7.24e-03

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 35.89  E-value: 7.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238231421  22 PKEISGFEGDTVSLRCTYV--EKMKEHRKYWCRQGGilVSRCGDIVYANQD----QEVTRGRMSIRDSPQEL-SMTVIMR 94
Cdd:cd05718    6 PTEVTGFLGGSVTLPCSLTspGTTKITQVTWMKIGA--GSSQNVAVFHPQYgpsvPNPYAERVEFLAARLGLrNATLRIR 83

                         90
                 ....*....|..
gi 238231421  95 DLTLKDSGKYWC 106
Cdd:cd05718   84 NLRVEDEGNYIC 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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