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Conserved domains on  [gi|237858701|ref|NP_001153716|]
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RPA-interacting protein isoform c [Homo sapiens]

Protein Classification

RPA_interact_N and RPA_interact_M domain-containing protein( domain architecture ID 10632126)

protein containing domains RPA_interact_N, RPA_interact_M, and RPA_interact_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPA_interact_N pfam14766
Replication protein A interacting N-terminal; This family of proteins represents the ...
 8-47 3.99e-15

Replication protein A interacting N-terminal; This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta.


:

Pssm-ID: 464304  Cd Length: 39  Bit Score: 65.23  E-value: 3.99e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 237858701    8 PRRSLYKlVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQA 47
Cdd:pfam14766   1 PRRASYK-SRSPPWKETLRERCLERLRESRQQLLWKFRSG 39
RPA_interact_M pfam14767
Replication protein A interacting middle; This family of proteins represents the middle domain ...
 60-127 4.74e-14

Replication protein A interacting middle; This family of proteins represents the middle domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA.


:

Pssm-ID: 434193  Cd Length: 82  Bit Score: 63.97  E-value: 4.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237858701   60 LVQEVMEEEWNALQSVENCPE-------DLAQLEELIDM------AVLEEIQQELINQEQSIISEYEKSLQFDEKCLSIM 126
Cdd:pfam14767   2 AVQEVMSDELEKLKQSSTSLPslkiptaDNDDMGESEDIllemelALYEDIQQELMSQELSILEEYEESLQEEEEYLAAA 81


                  .
gi 237858701  127 L 127
Cdd:pfam14767  82 V 82
RPA_interact_C super family cl20691
Replication protein A interacting C-terminal; This family of proteins represents the ...
 136-165 7.84e-08

Replication protein A interacting C-terminal; This family of proteins represents the C-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The C-terminal domain is a putative zinc finger.


The actual alignment was detected with superfamily member pfam14768:

Pssm-ID: 464305  Cd Length: 80  Bit Score: 47.29  E-value: 7.84e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 237858701  136 ICPVCTKYNLRITSGVVVCQCGLSIPSHAC 165
Cdd:pfam14768   1 ICPVCQKGNLRENSNFISCSCGLRLNTGDS 30
 
Name Accession Description Interval E-value
RPA_interact_N pfam14766
Replication protein A interacting N-terminal; This family of proteins represents the ...
 8-47 3.99e-15

Replication protein A interacting N-terminal; This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta.


Pssm-ID: 464304  Cd Length: 39  Bit Score: 65.23  E-value: 3.99e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 237858701    8 PRRSLYKlVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQA 47
Cdd:pfam14766   1 PRRASYK-SRSPPWKETLRERCLERLRESRQQLLWKFRSG 39
RPA_interact_M pfam14767
Replication protein A interacting middle; This family of proteins represents the middle domain ...
 60-127 4.74e-14

Replication protein A interacting middle; This family of proteins represents the middle domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA.


Pssm-ID: 434193  Cd Length: 82  Bit Score: 63.97  E-value: 4.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237858701   60 LVQEVMEEEWNALQSVENCPE-------DLAQLEELIDM------AVLEEIQQELINQEQSIISEYEKSLQFDEKCLSIM 126
Cdd:pfam14767   2 AVQEVMSDELEKLKQSSTSLPslkiptaDNDDMGESEDIllemelALYEDIQQELMSQELSILEEYEESLQEEEEYLAAA 81


                  .
gi 237858701  127 L 127
Cdd:pfam14767  82 V 82
RPA_interact_C pfam14768
Replication protein A interacting C-terminal; This family of proteins represents the ...
 136-165 7.84e-08

Replication protein A interacting C-terminal; This family of proteins represents the C-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The C-terminal domain is a putative zinc finger.


Pssm-ID: 464305  Cd Length: 80  Bit Score: 47.29  E-value: 7.84e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 237858701  136 ICPVCTKYNLRITSGVVVCQCGLSIPSHAC 165
Cdd:pfam14768   1 ICPVCQKGNLRENSNFISCSCGLRLNTGDS 30
 
Name Accession Description Interval E-value
RPA_interact_N pfam14766
Replication protein A interacting N-terminal; This family of proteins represents the ...
 8-47 3.99e-15

Replication protein A interacting N-terminal; This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta.


Pssm-ID: 464304  Cd Length: 39  Bit Score: 65.23  E-value: 3.99e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 237858701    8 PRRSLYKlVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQA 47
Cdd:pfam14766   1 PRRASYK-SRSPPWKETLRERCLERLRESRQQLLWKFRSG 39
RPA_interact_M pfam14767
Replication protein A interacting middle; This family of proteins represents the middle domain ...
 60-127 4.74e-14

Replication protein A interacting middle; This family of proteins represents the middle domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA.


Pssm-ID: 434193  Cd Length: 82  Bit Score: 63.97  E-value: 4.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237858701   60 LVQEVMEEEWNALQSVENCPE-------DLAQLEELIDM------AVLEEIQQELINQEQSIISEYEKSLQFDEKCLSIM 126
Cdd:pfam14767   2 AVQEVMSDELEKLKQSSTSLPslkiptaDNDDMGESEDIllemelALYEDIQQELMSQELSILEEYEESLQEEEEYLAAA 81


                  .
gi 237858701  127 L 127
Cdd:pfam14767  82 V 82
RPA_interact_C pfam14768
Replication protein A interacting C-terminal; This family of proteins represents the ...
 136-165 7.84e-08

Replication protein A interacting C-terminal; This family of proteins represents the C-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The C-terminal domain is a putative zinc finger.


Pssm-ID: 464305  Cd Length: 80  Bit Score: 47.29  E-value: 7.84e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 237858701  136 ICPVCTKYNLRITSGVVVCQCGLSIPSHAC 165
Cdd:pfam14768   1 ICPVCQKGNLRENSNFISCSCGLRLNTGDS 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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