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Conserved domains on  [gi|23397572|ref|NP_695002|]
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kelch-like protein 34 [Homo sapiens]

Protein Classification

kelch-like protein 34( domain architecture ID 13033229)

kelch-like protein 34 (KLHL34) is a BTB-Kelch family protein

Gene Ontology:  GO:0005515
PubMed:  10603472|27521773|17120193|15544948
SCOP:  4003219|4001139

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-136 3.72e-90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 275.52  E-value: 3.72e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   1 MSYFLSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGL 80
Cdd:cd18264   1 MSYFLAYSKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23397572  81 QRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAAN 136
Cdd:cd18264  81 QRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENCCFSAN 136
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 126-233 1.19e-55

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


:

Pssm-ID: 350548  Cd Length: 106  Bit Score: 184.17  E-value: 1.19e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 126 LAPENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLR 205
Cdd:cd18473   1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLASDADDAGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLN 80

                        90       100
                ....*....|....*....|....*...
gi 23397572 206 QEPttERLAHCTELLERVRFGLVPADVL 233
Cdd:cd18473  81 QDE--SRLAYANALLSRIRYGLVPVEEL 106
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
333-578 3.65e-30

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 119.88  E-value: 3.65e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 333 TQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTA-GNFLFVLGGESPSGSASSPLADdsrvvtaqVHRYDPRFHAWTEVPAM 411
Cdd:COG3055  37 SNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVFGGFTGANPSSTPLND--------VYVYDPATNTWTKLAPM 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 412 REARAHFWCGAVGERLLAVGGLGAGGEVlASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGvvyisggkagrgeggas 491
Cdd:COG3055 109 PTPRGGATALLLDGKIYVVGGWDDGGNV-AWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDG----------------- 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 492 slrDLYVLG-----PEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSEIERYDPGADQWTRLRPLPYDRFCYGL 566
Cdd:COG3055 171 ---KILVIGgrngsGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGELPTPRHGHAA 247

                       250
                ....*....|..
gi 23397572 567 AVVEETALLLGG 578
Cdd:COG3055 248 VLTDGKVYVIGG 259
 
Name Accession Description Interval E-value
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-136 3.72e-90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 275.52  E-value: 3.72e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   1 MSYFLSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGL 80
Cdd:cd18264   1 MSYFLAYSKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23397572  81 QRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAAN 136
Cdd:cd18264  81 QRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENCCFSAN 136
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 126-233 1.19e-55

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 184.17  E-value: 1.19e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 126 LAPENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLR 205
Cdd:cd18473   1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLASDADDAGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLN 80

                        90       100
                ....*....|....*....|....*...
gi 23397572 206 QEPttERLAHCTELLERVRFGLVPADVL 233
Cdd:cd18473  81 QDE--SRLAYANALLSRIRYGLVPVEEL 106
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
333-578 3.65e-30

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 119.88  E-value: 3.65e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 333 TQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTA-GNFLFVLGGESPSGSASSPLADdsrvvtaqVHRYDPRFHAWTEVPAM 411
Cdd:COG3055  37 SNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVFGGFTGANPSSTPLND--------VYVYDPATNTWTKLAPM 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 412 REARAHFWCGAVGERLLAVGGLGAGGEVlASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGvvyisggkagrgeggas 491
Cdd:COG3055 109 PTPRGGATALLLDGKIYVVGGWDDGGNV-AWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDG----------------- 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 492 slrDLYVLG-----PEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSEIERYDPGADQWTRLRPLPYDRFCYGL 566
Cdd:COG3055 171 ---KILVIGgrngsGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGELPTPRHGHAA 247

                       250
                ....*....|..
gi 23397572 567 AVVEETALLLGG 578
Cdd:COG3055 248 VLTDGKVYVIGG 259
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 19-126 1.05e-28

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 110.04  E-value: 1.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572    19 YQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLsLSMDT 98
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 23397572    99 VEDTLEAASYLQVTEALGLCGRYLERQL 126
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 30-126 6.41e-24

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 96.22  E-value: 6.41e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572     30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYL 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 23397572    110 QVTEALGLCGRYLERQL 126
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
PHA03098 PHA03098
kelch-like protein; Provisional
 29-603 5.89e-14

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 74.80  E-value: 5.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   29 CDVTL--ETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPsaagLQRLLDFIYTAWLSLSMDTVEDTLEAA 106
Cdd:PHA03098  10 CDESIiiVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINLNIDYDS----FNEVIKYIYTGKINITSNNVKDILSIA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  107 SYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARgagpAGLLELNPTSLRAVLGAP 186
Cdd:PHA03098  86 NYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYND----PDFIYLSKNELIKILSDD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  187 DVARVPEARLLGLALAWLRQEPTtERLAHCTELLERVRFGLVPADVLRRvysgsglvlparvkgliIQALNYHTTPSRQP 266
Cdd:PHA03098 162 KLNVSSEDVVLEIIIKWLTSKKN-NKYKDICLILKVLRITFLSEEGIKK-----------------LKRWKLRIKKKKIV 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  267 LMQGEQTSIRSpqtrillVGGRRAREVVIEEvaapqraargqvaapepeeEEEELEEEEEEEEWELTQNVVAFDVYNhRW 346
Cdd:PHA03098 224 FNKRCIKIIYS-------KKYNLNKILPRSS-------------------TFGSIIYIHITMSIFTYNYITNYSPLS-EI 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  347 RSLTQLPTPLLGHSVcTAGNFLFVLGGespsgsassplADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGER 426
Cdd:PHA03098 277 NTIIDIHYVYCFGSV-VLNNVIYFIGG-----------MNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNR 344

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  427 LLAVGGLGAGGEVlASVEMYDLRRDRWTAAGAL--PRAlhgHAGAVGDRGVVYIsggkAGRGEGGASSLRDLYVLGPEEQ 504
Cdd:PHA03098 345 IYVIGGIYNSISL-NTVESWKPGESKWREEPPLifPRY---NPCVVNVNNLIYV----IGGISKNDELLKTVECFSLNTN 416

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  505 VWSKKAPMGTARFGHHMAVLRGAVFAFLG-----RYEPFSEIERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGL 579
Cdd:PHA03098 417 KWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGD 496

                        570       580
                 ....*....|....*....|....
gi 23397572  580 KWRdsrqVPTRNVVGYDLDLDRWE 603
Cdd:PHA03098 497 KYE----YYINEIEVYDDKTNTWT 516
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 131-236 1.16e-11

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 61.59  E-value: 1.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572    131 CCFAANVAARFGLAHTLDAAERCIVSHLQELlargAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLRQEPTt 210
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEV----SSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPE- 75

                           90       100
                   ....*....|....*....|....*.
gi 23397572    211 ERLAHCTELLERVRFGLVPADVLRRV 236
Cdd:smart00875  76 KRREHLPELLEHVRLPLLSPDYLLEV 101
Kelch_6 pfam13964
Kelch motif;
357-415 7.49e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.40  E-value: 7.49e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 23397572   357 LGHSVCTAGNFLFVLGGESPSGSASSpladdsrvvtaQVHRYDPRFHAWTEVPAMREAR 415
Cdd:pfam13964   3 TFHSVVSVGGYIYVFGGYTNASPALN-----------KLEVYNPLTKSWEELPPLPTPR 50
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 131-236 1.99e-04

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 40.99  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   131 CCFAANVAARFGLAHTLDAAERCIVSHLQELLARgagpAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLRQEPTt 210
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKS----EEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVE- 75

                          90       100
                  ....*....|....*....|....*.
gi 23397572   211 ERLAHCTELLERVRFGLVPADVLRRV 236
Cdd:pfam07707  76 RRKKHLPELLSAVRLPLLSPQYLLNL 101
Kelch smart00612
Kelch domain;
441-472 8.06e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.84  E-value: 8.06e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 23397572    441 ASVEMYDLRRDRWTAAGALPRALHGHAGAVGD 472
Cdd:smart00612  15 KSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
 
Name Accession Description Interval E-value
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-136 3.72e-90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 275.52  E-value: 3.72e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   1 MSYFLSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGL 80
Cdd:cd18264   1 MSYFLAYSKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23397572  81 QRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAAN 136
Cdd:cd18264  81 QRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENCCFSAN 136
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 126-233 1.19e-55

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 184.17  E-value: 1.19e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 126 LAPENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLR 205
Cdd:cd18473   1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLASDADDAGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLN 80

                        90       100
                ....*....|....*....|....*...
gi 23397572 206 QEPttERLAHCTELLERVRFGLVPADVL 233
Cdd:cd18473  81 QDE--SRLAYANALLSRIRYGLVPVEEL 106
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-131 1.02e-38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 138.68  E-value: 1.02e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18255   1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18255  81 ELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-131 3.26e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 132.24  E-value: 3.26e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSE--FPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIY 88
Cdd:cd18239   6 HSSVVLQGFDQLRGEGLLCDVTLVPGDGDetFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIY 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 23397572  89 TAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18239  86 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-131 1.05e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 119.47  E-value: 1.05e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   6 SYCKAhggaLLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLD 85
Cdd:cd18242   3 SHAKS----ILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLD 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 23397572  86 FIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18242  79 FVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
333-578 3.65e-30

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 119.88  E-value: 3.65e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 333 TQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTA-GNFLFVLGGESPSGSASSPLADdsrvvtaqVHRYDPRFHAWTEVPAM 411
Cdd:COG3055  37 SNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVFGGFTGANPSSTPLND--------VYVYDPATNTWTKLAPM 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 412 REARAHFWCGAVGERLLAVGGLGAGGEVlASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGvvyisggkagrgeggas 491
Cdd:COG3055 109 PTPRGGATALLLDGKIYVVGGWDDGGNV-AWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDG----------------- 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 492 slrDLYVLG-----PEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSEIERYDPGADQWTRLRPLPYDRFCYGL 566
Cdd:COG3055 171 ---KILVIGgrngsGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGELPTPRHGHAA 247

                       250
                ....*....|..
gi 23397572 567 AVVEETALLLGG 578
Cdd:COG3055 248 VLTDGKVYVIGG 259
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-109 1.64e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 111.49  E-value: 1.64e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAAS 107
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                ..
gi 23397572 108 YL 109
Cdd:cd18186  81 KL 82
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-131 1.87e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 112.94  E-value: 1.87e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  10 AHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYT 89
Cdd:cd18250   3 AHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYT 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 23397572  90 AWLSLSMDTVEDTLEAASYLQ---VTEAlglCGRYLERQLAPENC 131
Cdd:cd18250  83 GRVTVTQDNVEALLRAADLFQfpsVKEA---CCAYLQQRLDVSNC 124
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 19-126 1.05e-28

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 110.04  E-value: 1.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572    19 YQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLsLSMDT 98
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 23397572    99 VEDTLEAASYLQVTEALGLCGRYLERQL 126
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-131 4.20e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 106.22  E-value: 4.20e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  22 LRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVED 101
Cdd:cd18238   9 FYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQS 88

                        90       100       110
                ....*....|....*....|....*....|
gi 23397572 102 TLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18238  89 LLYAASLLQVEEVAKACCEFMKDHLHPSNC 118
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-131 7.32e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 106.19  E-value: 7.32e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   7 YCKA-HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLD 85
Cdd:cd18244   8 YNSSiHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQ 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 23397572  86 FIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18244  88 FMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNC 133
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-126 1.86e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 104.66  E-value: 1.86e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   5 LSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLL 84
Cdd:cd18261   5 LCQSKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQAL 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 23397572  85 DFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQL 126
Cdd:cd18261  85 DFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQEL 126
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-130 1.40e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 102.20  E-value: 1.40e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  10 AHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYT 89
Cdd:cd18251   5 AHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYT 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 23397572  90 AWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPEN 130
Cdd:cd18251  85 SELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-128 4.26e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 100.58  E-value: 4.26e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  21 ALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVE 100
Cdd:cd18235  14 ELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQ 93

                        90       100
                ....*....|....*....|....*...
gi 23397572 101 DTLEAASYLQVTEALGLCGRYLERQLAP 128
Cdd:cd18235  94 VLLPAANLLQLTDVRDACCDFLQSQLHP 121
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-131 4.50e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 100.56  E-value: 4.50e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18256   3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTG 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18256  83 VVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNC 123
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-131 5.87e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 100.29  E-value: 5.87e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18253   1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18253  81 KVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-131 1.60e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 98.94  E-value: 1.60e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  19 YQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDT 98
Cdd:cd18240   8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAEN 87

                        90       100       110
                ....*....|....*....|....*....|...
gi 23397572  99 VEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18240  88 VEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-131 1.75e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 99.52  E-value: 1.75e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   5 LSYC-KAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRL 83
Cdd:cd18259   8 LDFClPSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESL 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 23397572  84 LDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18259  88 IDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNC 135
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-131 3.38e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 98.32  E-value: 3.38e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  15 LLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSL 94
Cdd:cd18268  10 LLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILI 89

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 23397572  95 SMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18268  90 TRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENC 126
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 30-126 6.41e-24

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 96.22  E-value: 6.41e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572     30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYL 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 23397572    110 QVTEALGLCGRYLERQL 126
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-131 1.93e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 95.13  E-value: 1.93e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAAS 107
Cdd:cd18234   1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                        90       100
                ....*....|....*....|....
gi 23397572 108 YLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18234  81 LLQLSEVVEACCGFLMKQLHPSNC 104
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-131 2.26e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 95.63  E-value: 2.26e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  20 QALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTV 99
Cdd:cd18237  13 NNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNNV 92

                        90       100       110
                ....*....|....*....|....*....|..
gi 23397572 100 EDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18237  93 QSLLDAANQYQIEPVKKMCVDFLKEQLDASNC 124
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-131 3.31e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 95.27  E-value: 3.31e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKshtQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18260   1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLGLATVITYAYTG 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18260  78 KLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENC 118
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-118 3.79e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 94.61  E-value: 3.79e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQesrarVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18206   5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKD-----VVHLDISNAAGLGQVLEFMYTA 79

                        90       100
                ....*....|....*....|....*...
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLC 118
Cdd:cd18206  80 KLSLSPENVDDVLAVATFLQMQDIVTAC 107
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-131 1.40e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 93.68  E-value: 1.40e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18265   6 HAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGG 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18265  86 GLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNC 126
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-131 1.66e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 93.53  E-value: 1.66e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  14 ALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLS 93
Cdd:cd18270  12 SLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLA 91

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 23397572  94 LSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18270  92 INDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENC 129
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 16-131 2.27e-22

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 92.57  E-value: 2.27e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  16 LTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLS 95
Cdd:cd18263   1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLS 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 23397572  96 MDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18263  81 WENLFEATCTALQLQISGALALCLDFLQREISPARC 116
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-123 3.46e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 92.02  E-value: 3.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  15 LLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSH---TQESRARVIHLHVpSAAGLQRLLDFIYTAW 91
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNppkDDGSTYKIELEGI-SVEVMEEILDYIYTGQ 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 23397572  92 LSLSMDTVEDTLEAASYLQVTEALGLCGRYLE 123
Cdd:cd18245  80 IKLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-131 1.90e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 90.01  E-value: 1.90e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18306  81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNC 121
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-123 1.04e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 88.07  E-value: 1.04e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18326   8 HSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTA 87

                        90       100       110
                ....*....|....*....|....*....|...
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLE 123
Cdd:cd18326  88 TLTVSTSNVGDILSAARLLEIPAVSHVCADLLD 120
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-131 1.14e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 88.73  E-value: 1.14e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  10 AHGGALLTGYQALRAEGFLCDVTLETEGSE--------FPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQ 81
Cdd:cd18273   8 AHARALLAQLKSFYDARLLTDVTIEVNGPGsgpgsgrlFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMA 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 23397572  82 RLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18273  88 LIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNC 137
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
404-578 1.25e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 92.14  E-value: 1.25e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 404 AWTEVPAMREARAHFwCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKA 483
Cdd:COG3055   2 TWSSLPDLPTPRSEA-AAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 484 GRGEGGaSSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPF--SEIERYDPGADQWTRLRPLPYDR 561
Cdd:COG3055  81 GANPSS-TPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGnvAWVEVYDPATGTWTQLAPLPTPR 159

                       170
                ....*....|....*..
gi 23397572 562 FCYGLAVVEETALLLGG 578
Cdd:COG3055 160 DHLAAAVLPDGKILVIG 176
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-128 1.52e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 87.59  E-value: 1.52e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTG 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAP 128
Cdd:cd18257  81 TVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-130 2.07e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 87.64  E-value: 2.07e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18266   8 HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYSS 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPEN 130
Cdd:cd18266  88 ELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEEN 127
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-131 4.50e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 86.44  E-value: 4.50e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  13 GALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWL 92
Cdd:cd18236   9 LVLQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKV 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 23397572  93 SLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18236  89 LITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENC 127
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-123 6.28e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 85.33  E-value: 6.28e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRaRVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18233   1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKN-DVFHLDIKNVGGIGQILDFMYTS 79

                        90       100       110
                ....*....|....*....|....*....|...
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLE 123
Cdd:cd18233  80 HLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-131 1.03e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 85.72  E-value: 1.03e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   2 SYFLSYC---KAHGGALLTGYQAL-RAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSA 77
Cdd:cd18272   2 NYFVSYTftdRSHSSRVAQSIMDLcLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSE 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 23397572  78 AGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18272  82 SVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNC 135
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-122 1.27e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 84.91  E-value: 1.27e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALF-------KSHTQESRARVIHLHVPSAAGLQRL 83
Cdd:cd18228   2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLvgqasprLVLVSPAGKCVLDLHHVTVTGFAPL 81

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 23397572  84 LDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYL 122
Cdd:cd18228  82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-123 1.52e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 84.53  E-value: 1.52e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18198   8 HSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYTA 87

                        90       100       110
                ....*....|....*....|....*....|...
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLE 123
Cdd:cd18198  88 TLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-128 2.00e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 84.35  E-value: 2.00e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  22 LRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVED 101
Cdd:cd18338  15 LRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQV 94

                        90       100
                ....*....|....*....|....*..
gi 23397572 102 TLEAASYLQVTEALGLCGRYLERQLAP 128
Cdd:cd18338  95 LLPAAGLLQLQDVKKTCCEFLESQLHP 121
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-128 2.17e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 84.39  E-value: 2.17e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  10 AHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYT 89
Cdd:cd18339   3 AHMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYT 82

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 23397572  90 AWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAP 128
Cdd:cd18339  83 AEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-118 2.47e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 83.65  E-value: 2.47e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQEsrarVIHLHVP--SAAGLQRLLDFIY 88
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDN----IVFLDQSqvSADGFQKLLEFIY 76

                        90       100       110
                ....*....|....*....|....*....|
gi 23397572  89 TAWLSLSMDTVEDTLEAASYLQVTEALGLC 118
Cdd:cd18217  77 TGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-125 4.39e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 83.10  E-value: 4.39e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  20 QALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTV 99
Cdd:cd18247  11 EEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTSNV 90

                        90       100
                ....*....|....*....|....*.
gi 23397572 100 EDTLEAASYLQVTEALGLCGRYLERQ 125
Cdd:cd18247  91 QSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-126 4.47e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 83.57  E-value: 4.47e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  10 AHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALF-KSHTQESRARVIHLHVPSAAGLQRLLDFIY 88
Cdd:cd18230   3 SHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYcQVQKTSDQATVTHLDIVTAQGFKAIIDFMY 82

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 23397572  89 TAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQL 126
Cdd:cd18230  83 SAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAAL 120
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-131 6.65e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 83.17  E-value: 6.65e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAAS 107
Cdd:cd18336  19 LCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESLLAAAC 98

                        90       100
                ....*....|....*....|....
gi 23397572 108 YLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18336  99 LLQLSQVIDVCCNFLMKQLHPSNC 122
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-131 7.84e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 82.93  E-value: 7.84e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18276   4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSS 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18276  84 DLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNC 124
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-129 1.35e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 82.18  E-value: 1.35e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKShtQESRARVIHLH--VPSAAGLQRLLDFIY 88
Cdd:cd18194   6 HSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRD--RLDKRDLVRLNsdIVTAPAFGLLLDFMY 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 23397572  89 TAWLSLSMDTVEDTLEAASYLQVTEALGLC-GRYLERQLAPE 129
Cdd:cd18194  84 EGRLALRDLPVEDVLAAASYLHMYDIVKVCkGRLQEKALAEA 125
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-126 1.72e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 81.66  E-value: 1.72e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  22 LRAEGFLCDVTLETEGS----EFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMD 97
Cdd:cd18248  15 LRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTASISVGEK 94

                        90       100
                ....*....|....*....|....*....
gi 23397572  98 TVEDTLEAASYLQVTEALGLCGRYLERQL 126
Cdd:cd18248  95 CVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-106 2.17e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 81.13  E-value: 2.17e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLS---MDTVEDTLEAA 106
Cdd:cd18287  24 DVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRLTLTdlkEDVLLDVLGLA 103
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-131 2.84e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 81.96  E-value: 2.84e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   1 MSYFLSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHV---PSA 77
Cdd:cd18267  13 MNIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDsihPEV 92

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 23397572  78 agLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18267  93 --LELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNC 144
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-131 4.33e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 80.91  E-value: 4.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  15 LLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSL 94
Cdd:cd18269  14 LQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDL 93

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 23397572  95 SMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18269  94 NDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNC 130
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-130 6.85e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 80.47  E-value: 6.85e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTqesrarvIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18243  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSINN-------LVLQGCSSIGLRLVLEYLYTA 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPEN 130
Cdd:cd18243  88 NVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-131 1.43e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 79.49  E-value: 1.43e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYL 109
Cdd:cd18340  29 DCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMF 108

                        90       100
                ....*....|....*....|..
gi 23397572 110 QVTEALGLCGRYLERQLAPENC 131
Cdd:cd18340 109 QIPSIFTVCVSFLQKRLCLSNC 130
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-131 2.32e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 78.65  E-value: 2.32e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18249   6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTS 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18249  86 QITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNC 126
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-119 2.94e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 78.29  E-value: 2.94e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  26 GFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQ-ESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLE 104
Cdd:cd18293  13 GVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPpAGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLA 92

                        90
                ....*....|....*
gi 23397572 105 AASYLQVTEALGLCG 119
Cdd:cd18293  93 AARRLQISELESLCL 107
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-122 3.84e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 77.46  E-value: 3.84e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  23 RAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQES-RARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVED 101
Cdd:cd18199  13 RKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTgRPSTASFDVFSSDAFSIILDFVYSGKLSLTSQNVIE 92

                        90       100
                ....*....|....*....|.
gi 23397572 102 TLEAASYLQVTEALGLCGRYL 122
Cdd:cd18199  93 VMSAASYLQMTDVINVCKTFI 113
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-122 6.07e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 76.89  E-value: 6.07e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  15 LLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQES-RARVIHLHVPSAAGLQRLLDFIYTAWLS 93
Cdd:cd18330   5 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSgRHSTASLDIVTSEAFSIILDFLYSGKLD 84

                        90       100
                ....*....|....*....|....*....
gi 23397572  94 LSMDTVEDTLEAASYLQVTEALGLCGRYL 122
Cdd:cd18330  85 LCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-121 8.69e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 76.34  E-value: 8.69e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  23 RAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESrarvIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDT 102
Cdd:cd18232  13 REEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGS----VVLPESFAEVFGLLLDFFYTGELALTRENRDRV 88

                        90
                ....*....|....*....
gi 23397572 103 LEAASYLQVTEALGLCGRY 121
Cdd:cd18232  89 LLAAKELRVPEAVELCQRF 107
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-131 9.08e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 76.97  E-value: 9.08e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  10 AHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHV---PSAagLQRLLDF 86
Cdd:cd18254   4 SHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDslhPEV--LELLLDF 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 23397572  87 IYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18254  82 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNC 126
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-127 1.72e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 76.02  E-value: 1.72e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18323   6 HSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRDLVCINNEIVTAPAFSLLLEFMYEG 85

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLE-RQLA 127
Cdd:cd18323  86 RLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQaRALA 123
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-129 1.81e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 76.00  E-value: 1.81e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARV-IHLHVPSAAGLQRLLDFIYT 89
Cdd:cd18956   6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGRDTVrLNGDIVTAPAFGRLLDFMYE 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 23397572  90 AWLSLSMDTVEDTLEAASYLQVTEALGLC-GRYLERQLAPE 129
Cdd:cd18956  86 GRLDLRSLPVEDVLAAASYLHMYDIVKVCkGRLREKDPALP 126
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-130 1.88e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 76.23  E-value: 1.88e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKShtQESRARVIHLH--VPSAAGLQRLLDFIY 88
Cdd:cd18325   6 HSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRD--QLDKRDIVHLNsdIVTAPAFSLLLEFMY 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 23397572  89 TAWLSLSMDTVEDTLEAASYLQVTEALGLC-GRYLERQLAPEN 130
Cdd:cd18325  84 EGKLEFSSLPVEDVLAAASYLHMYDIVKVCkGKLKDKELCSEE 126
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-131 8.62e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 74.10  E-value: 8.62e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   8 CKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFI 87
Cdd:cd18271   4 AECHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYA 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 23397572  88 YTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18271  84 YTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNC 127
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-126 1.18e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 73.45  E-value: 1.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   6 SYCKAhggaLLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRAR--VIHLHVPSAAGLQRL 83
Cdd:cd18201   3 SYCYQ----LLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQttVTHLDVVAVQGFSVI 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 23397572  84 LDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQL 126
Cdd:cd18201  79 LDFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDAL 121
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-131 1.25e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 73.54  E-value: 1.25e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAAS 107
Cdd:cd18335  19 LCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAAC 98

                        90       100
                ....*....|....*....|....
gi 23397572 108 YLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18335  99 LLQLSQVVEVCCHFLMKLLHPSNC 122
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-118 1.48e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 72.94  E-value: 1.48e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  10 AHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQE-SRARVIHLHVPSAAGLQRLLDFIY 88
Cdd:cd18329   3 SHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKEtGQPTVATFDVFSPDTFTIILDFVY 82

                        90       100       110
                ....*....|....*....|....*....|
gi 23397572  89 TAWLSLSMDTVEDTLEAASYLQVTEALGLC 118
Cdd:cd18329  83 SGKLSLTSQNVIEVMSAASYLQMTDVISVC 112
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-131 1.89e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 73.10  E-value: 1.89e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  10 AHGGALLTGYQALRAEGFLCDVTLETE-GSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIY 88
Cdd:cd18274   4 LHACSILQQLKAMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAY 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 23397572  89 TAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18274  84 TSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNS 126
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-111 2.05e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 72.91  E-value: 2.05e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   9 KAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRArVIHLHVPSAAGLQRLLDFIY 88
Cdd:cd18212   4 KTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQS-IYMLEGMVAETFGALLEFIY 82

                        90       100
                ....*....|....*....|...
gi 23397572  89 TAWLSLSMDTVEDTLEAASYLQV 111
Cdd:cd18212  83 TGCLQVGEKSLEQILATAQFLKV 105
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-123 4.09e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 71.84  E-value: 4.09e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18328   8 HSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYTS 87

                        90       100       110
                ....*....|....*....|....*....|...
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLE 123
Cdd:cd18328  88 TLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-111 5.13e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 71.80  E-value: 5.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESR-------ARVIHLHVPSAAGLQRL 83
Cdd:cd18327   8 HSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGdlgagggQDVCELDFVGPEALGAL 87

                        90       100
                ....*....|....*....|....*...
gi 23397572  84 LDFIYTAWLSLSMDTVEDTLEAASYLQV 111
Cdd:cd18327  88 LEFAYTATLTISSSNMREVLRAARLLEI 115
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-131 6.08e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 71.78  E-value: 6.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  10 AHGGALLTGYQALRAEGFLCDVTLE-TEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIY 88
Cdd:cd18252   3 SHPADFLDAFRTFYLDGLFTDITLQcASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVY 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 23397572  89 TAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18252  83 TSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNC 125
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-124 6.70e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 71.54  E-value: 6.70e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTqesrarVIHLHVP--SAAGLQRLLDFIY 88
Cdd:cd18334   4 HAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDN------LINLDTDmvNPTVFRQILDFIY 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 23397572  89 TAWLsLSMDTVEDT-----LEAASYLQVTEALGLCGRYLER 124
Cdd:cd18334  78 TGKL-LTSDQPGEQnfnalLTAASYLQLHDLAALCRKKLKR 117
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-129 7.66e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 71.99  E-value: 7.66e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKShtQESRARVIHLH--VPSAAGLQRLLDFIY 88
Cdd:cd18324   6 HSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKD--QLDKRDIVHLNsdIVTAPAFALLLEFMY 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 23397572  89 TAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPE 129
Cdd:cd18324  84 EGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTE 124
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-128 8.20e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 71.60  E-value: 8.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  22 LRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVED 101
Cdd:cd18246  33 MRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQT 112

                        90       100
                ....*....|....*....|....*..
gi 23397572 102 TLEAASYLQVTEALGLCGRYLERQLAP 128
Cdd:cd18246 113 LLPAASLLQLNGVRDACCKFLLSQLDP 139
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-118 1.34e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 70.34  E-value: 1.34e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  28 LCDV--TLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARvIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEA 105
Cdd:cd18231  14 LCDVdiVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQRVE-LSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNA 92

                        90
                ....*....|...
gi 23397572 106 ASYLQVTEALGLC 118
Cdd:cd18231  93 AAVLQMNDIAASC 105
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-131 1.39e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 70.86  E-value: 1.39e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAAS 107
Cdd:cd18337  23 LCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYTGRLELKEDNIECLLSTAC 102

                        90       100
                ....*....|....*....|....
gi 23397572 108 YLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18337 103 LLQLSQVVEACCKFLMKQLHPSNC 126
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-118 3.35e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 69.49  E-value: 3.35e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALF--KSHTQESRArVIHLHVPSAAGLQRLLDFIY 88
Cdd:cd18202   2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFieKGAVSSHEA-VVDLSGFCKSSFLPLLEFAY 80

                        90       100       110
                ....*....|....*....|....*....|
gi 23397572  89 TAWLSLSMDTVEDTLEAASYLQVTEALGLC 118
Cdd:cd18202  81 TSELTFDFCSMAEVAMLARHLFMNEVLEIC 110
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-131 3.49e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 69.87  E-value: 3.49e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  15 LLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSL 94
Cdd:cd18341  14 LQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDL 93

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 23397572  95 SMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18341  94 NDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANC 130
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-131 3.82e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 69.89  E-value: 3.82e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   8 CKAHGGALLTGYQALRAEGFLCDVTL---ETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAG----- 79
Cdd:cd18241   3 CSSHCSELSWRQNEQRKQGLFCDITLafgGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPgpdpd 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 23397572  80 -LQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18241  83 tVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
PHA03098 PHA03098
kelch-like protein; Provisional
 29-603 5.89e-14

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 74.80  E-value: 5.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   29 CDVTL--ETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPsaagLQRLLDFIYTAWLSLSMDTVEDTLEAA 106
Cdd:PHA03098  10 CDESIiiVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINLNIDYDS----FNEVIKYIYTGKINITSNNVKDILSIA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  107 SYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARgagpAGLLELNPTSLRAVLGAP 186
Cdd:PHA03098  86 NYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYND----PDFIYLSKNELIKILSDD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  187 DVARVPEARLLGLALAWLRQEPTtERLAHCTELLERVRFGLVPADVLRRvysgsglvlparvkgliIQALNYHTTPSRQP 266
Cdd:PHA03098 162 KLNVSSEDVVLEIIIKWLTSKKN-NKYKDICLILKVLRITFLSEEGIKK-----------------LKRWKLRIKKKKIV 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  267 LMQGEQTSIRSpqtrillVGGRRAREVVIEEvaapqraargqvaapepeeEEEELEEEEEEEEWELTQNVVAFDVYNhRW 346
Cdd:PHA03098 224 FNKRCIKIIYS-------KKYNLNKILPRSS-------------------TFGSIIYIHITMSIFTYNYITNYSPLS-EI 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  347 RSLTQLPTPLLGHSVcTAGNFLFVLGGespsgsassplADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGER 426
Cdd:PHA03098 277 NTIIDIHYVYCFGSV-VLNNVIYFIGG-----------MNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNR 344

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  427 LLAVGGLGAGGEVlASVEMYDLRRDRWTAAGAL--PRAlhgHAGAVGDRGVVYIsggkAGRGEGGASSLRDLYVLGPEEQ 504
Cdd:PHA03098 345 IYVIGGIYNSISL-NTVESWKPGESKWREEPPLifPRY---NPCVVNVNNLIYV----IGGISKNDELLKTVECFSLNTN 416

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  505 VWSKKAPMGTARFGHHMAVLRGAVFAFLG-----RYEPFSEIERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGL 579
Cdd:PHA03098 417 KWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGD 496

                        570       580
                 ....*....|....*....|....
gi 23397572  580 KWRdsrqVPTRNVVGYDLDLDRWE 603
Cdd:PHA03098 497 KYE----YYINEIEVYDDKTNTWT 516
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-123 6.23e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 68.34  E-value: 6.23e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFkshTQESRARVIHLHVPS---AAGLQRLLDFI 87
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIF---SGRVGEGVSVLTLPSgleARGFQLLLDFM 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 23397572  88 YTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLE 123
Cdd:cd18332  79 YTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-124 7.06e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 68.33  E-value: 7.06e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTqesrarVIHLH--VPSAAGLQRLLDFIY 88
Cdd:cd18216   3 HATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDN------LIHLDqdMVSPTVFQQILDFIY 76

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 23397572  89 TAWLSLSMDTVED---TLEAASYLQVTEALGLCGRYLER 124
Cdd:cd18216  77 TGKLLDSLFEEPNlseVLAAANYLQLPDLAALCRSKLKR 115
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-122 7.65e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 68.44  E-value: 7.65e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVpSAAGLQRLLDFIYTA 90
Cdd:cd18278  14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLPEEV-TARGFGPLLQFAYTA 92

                        90       100       110
                ....*....|....*....|....*....|..
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYL 122
Cdd:cd18278  93 KLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 31-109 9.95e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 66.54  E-value: 9.95e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23397572  31 VTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYL 109
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 28-111 1.86e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 66.03  E-value: 1.86e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRArVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAAS 107
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHP-VIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79


                ....
gi 23397572 108 YLQV 111
Cdd:cd18315  80 LLQI 83
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-131 2.14e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 67.31  E-value: 2.14e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  20 QALRAEGFlCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARV---IHLHVPSAAGLQRLLDFIYTAWLSLSM 96
Cdd:cd18258  10 QQRRAKEF-TDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEkleLTMSNINADVLELLLEFVYTGSLIIDS 88

                        90       100       110
                ....*....|....*....|....*....|....*
gi 23397572  97 DTVEDTLEAASYLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18258  89 ANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNC 123
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-115 6.16e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 65.83  E-value: 6.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  12 GGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKShtqeSRARVIHLhvPSAA---GLQRLLDFIY 88
Cdd:cd18290  11 GNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVEL--PAAVqpqSFQQILSFCY 84

                        90       100
                ....*....|....*....|....*..
gi 23397572  89 TAWLSLSMDTVEDTLEAASYLQVTEAL 115
Cdd:cd18290  85 TGRLSMNVGDQFLLMYTAGFLQIQEIM 111
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-124 6.94e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 65.69  E-value: 6.94e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  10 AHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFkshTQESRARVIHLHVpSAAGLQRLLDFIYT 89
Cdd:cd18333   3 SHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLV---VHDNLINLDHEMV-SPGIFRLILDYIYT 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 23397572  90 AWLSLSMDTVEDT----LEAASYLQVTEALGLCGRYLER 124
Cdd:cd18333  79 GRLSEGDPGSEQNlgavLAAASYLQIPDLVALCKKKLKR 117
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-118 7.98e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 65.62  E-value: 7.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFkSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18224   9 HPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLF-LSTELDVARTYVVDFITPANFEKVLSFIYTS 87

                        90       100
                ....*....|....*....|....*...
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLC 118
Cdd:cd18224  88 ELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-118 8.49e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 65.65  E-value: 8.49e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   9 KAHGGALLTGYQALRAEGFLCDVTLETE--GS--EFPAHRSLLACSSDYFRALF-KSHTQESRARVIHLHVPSAAGLQRL 83
Cdd:cd18211   6 KSAPSNLLNEMHKLRLLGHLCDVTVQVEhqGSkeEFSAHKAVLAASSKYFKEVFlNEKISDGKNTNVMLNEIYTADFASF 85

                        90       100       110
                ....*....|....*....|....*....|....*
gi 23397572  84 LDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLC 118
Cdd:cd18211  86 LEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETC 120
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-111 1.91e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 63.64  E-value: 1.91e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESrarvIHLHVP---SAAGLQRLLDFIYTAWLSLSMDTVEDTLE 104
Cdd:cd18955   1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGD----LVITLPeevTVKGFEPLLQFAYTAKLLLSKENVLEVCR 76


                ....*..
gi 23397572 105 AASYLQV 111
Cdd:cd18955  77 CAEFLGV 83
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-118 2.39e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 64.22  E-value: 2.39e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  26 GFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHT-QESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLE 104
Cdd:cd18207  25 GRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEgDGGTPRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMT 104

                        90
                ....*....|....
gi 23397572 105 AASYLQVTEALGLC 118
Cdd:cd18207 105 AAKFLLMRSVIDIC 118
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-123 3.41e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 63.91  E-value: 3.41e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  14 ALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRalfkSHTQESRARVIHLHVPSAAGL-QRLLDFIYTAWL 92
Cdd:cd18222  11 SVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFR----DHMSLNEMSTVSISVIKNPTVfEQLLSFCYTGRI 86

                        90       100       110
                ....*....|....*....|....*....|.
gi 23397572  93 SLSMDTVEDTLEAASYLQVTEALGLCGRYLE 123
Cdd:cd18222  87 CLQLADIISYLTAASFLQMQHIIDKCTQILE 117
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-94 7.15e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 62.99  E-value: 7.15e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHT-------------QESRARVIHL-HVPS 76
Cdd:cd18195   1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLplgaaavaaapgaTQSPERVLELpGVKA 80

                        90
                ....*....|....*...
gi 23397572  77 AAgLQRLLDFIYTAWLSL 94
Cdd:cd18195  81 GV-FSDVLNFIYSSRVAL 97
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 15-119 7.27e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 62.66  E-value: 7.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  15 LLTGYQalraEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSL 94
Cdd:cd18286   8 LLQLFL----NGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDL 83

                        90       100
                ....*....|....*....|....*
gi 23397572  95 SmdtveDTLEAASYLQVTEALGLCG 119
Cdd:cd18286  84 P-----DDVNLGELLSLADMYGLDG 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 131-236 1.16e-11

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 61.59  E-value: 1.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572    131 CCFAANVAARFGLAHTLDAAERCIVSHLQELlargAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLRQEPTt 210
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEV----SSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPE- 75

                           90       100
                   ....*....|....*....|....*.
gi 23397572    211 ERLAHCTELLERVRFGLVPADVLRRV 236
Cdd:smart00875  76 KRREHLPELLEHVRLPLLSPDYLLEV 101
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-121 1.18e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 61.92  E-value: 1.18e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  20 QALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKS-HTQESRARVIHLHVPS--AAGLQRLLDFIYTAWLSLSM 96
Cdd:cd18292   9 AQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNdWWSESKQSEIELVEDPecAAVFEKFLRYLYTGQISVNL 88

                        90       100
                ....*....|....*....|....*
gi 23397572  97 DTVEDTLEAASYLQVTEALGLCGRY 121
Cdd:cd18292  89 ETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-128 1.89e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 61.60  E-value: 1.89e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  19 YQALRaeGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHL--HVPSAAGLQRLLDFIYTAWLSLSM 96
Cdd:cd18196  14 YQRLH--GQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLdsEVVTAEAFAALIDMMYTSTLMLGE 91

                        90       100       110
                ....*....|....*....|....*....|..
gi 23397572  97 DTVEDTLEAASYLQVTEALGLCGRYLERQLAP 128
Cdd:cd18196  92 SNVMDVLLAASHLHLNSVVKACKHYLTTRTLP 123
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-112 1.90e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 61.34  E-value: 1.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18223   1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIYSS 80

                        90       100
                ....*....|....*....|...
gi 23397572  91 WLSL-SMDTVEDTLEAASYLQVT 112
Cdd:cd18223  81 KVVVkRQETVTDLVAAGKKLGIT 103
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-123 2.43e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 61.19  E-value: 2.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  15 LLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRalfkSHTQESRARVIHLHV-PSAAGLQRLLDFIYTAWLS 93
Cdd:cd18220  12 VLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFR----DHSALSTMSGLSISViKNPNVFEQLLSFCYTGRMS 87

                        90       100       110
                ....*....|....*....|....*....|
gi 23397572  94 LSMDTVEDTLEAASYLQVTEALGLCGRYLE 123
Cdd:cd18220  88 LQLKDVVSFLTAASFLQMQCVIDKCTQILE 117
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-121 2.50e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 61.04  E-value: 2.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYTS 81

                        90       100       110
                ....*....|....*....|....*....|.
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRY 121
Cdd:cd18215  82 RLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-125 2.89e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 60.43  E-value: 2.89e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRarvihLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18205   1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYT-----LDFLSPKTFQQILEYAYTA 75

                        90       100       110
                ....*....|....*....|....*....|....*
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVtealglcgRYLERQ 125
Cdd:cd18205  76 TLQAKVEDLDDLLYAAEILEI--------EYLEEQ 102
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-115 3.54e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 60.40  E-value: 3.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESrarVIHLHVPSAAGLQRLLDFIYTAWLSL-SMDTVEDTLEAASY 108
Cdd:cd18221  20 DITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEP---LVEIEGVSNMAFRHLIEFTYTAKLMVqGEEEANDVWKAAEY 96


                ....*..
gi 23397572 109 LQVTEAL 115
Cdd:cd18221  97 LQMQEAI 103
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 25-126 4.58e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 59.95  E-value: 4.58e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  25 EGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLS-LSMDTVEDTL 103
Cdd:cd18300   6 KGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPiLEDGDCVGLI 85

                        90       100
                ....*....|....*....|...
gi 23397572 104 EAASYLQVTEALGLCGRYLERQL 126
Cdd:cd18300  86 VLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-122 8.11e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 59.69  E-value: 8.11e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVpSAAGLQRLLDFIYTA 90
Cdd:cd18277  10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADAELNITLPEEV-TVKGFEPLIQFAYTA 88

                        90       100       110
                ....*....|....*....|....*....|..
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYL 122
Cdd:cd18277  89 KLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-110 1.13e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 58.34  E-value: 1.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  40 FPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLS----------MDTVEDTLEAASYL 109
Cdd:cd18319  13 YNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESqgdstdtleeNELLEDLVEAASFL 92


                .
gi 23397572 110 Q 110
Cdd:cd18319  93 Q 93
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-122 1.45e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 58.80  E-value: 1.45e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSdyfRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18218   1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGAS---QQLGRQLTNPNPGQWCLGEGISPSTFKQLLDFVYGE 77

                        90       100       110
                ....*....|....*....|....*....|..
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYL 122
Cdd:cd18218  78 SVEVQPGELRPLLEAARALEVESLEEACWRAL 109
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-131 2.79e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 57.50  E-value: 2.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRAlfkshtQESRaRVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYL 109
Cdd:cd18275   6 DLVIEVSGQRIRAHKSVLAAKSDYFRA------RLSR-DILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                        90       100
                ....*....|....*....|..
gi 23397572 110 QVTEALGLCGRYLERQLAPENC 131
Cdd:cd18275  79 QMPCAAQCAVDAVRAQLCLGNC 100
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-111 4.41e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 58.12  E-value: 4.41e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  12 GGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESrarvihLHVPSA---AGLQRLLDFIY 88
Cdd:cd18289  13 GNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSA------FELPATvppACFQQILSFCY 86

                        90       100
                ....*....|....*....|...
gi 23397572  89 TAWLSLSMDTVEDTLEAASYLQV 111
Cdd:cd18289  87 TGKLTMAASEQLVVMYTAGFLQI 109
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-123 4.76e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 57.17  E-value: 4.76e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFR-ALFKSHTQesraRVIHLHVPSAAGLQRLLDFIYT 89
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHdKLLLNDTN----CLVLPSVIEAAAFENLLQLIYS 76

                        90       100       110
                ....*....|....*....|....*....|....
gi 23397572  90 AWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLE 123
Cdd:cd18200  77 GRLTLCMDALPSHLLVASGLQMWQVVDRCSELLK 110
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-92 4.86e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 57.19  E-value: 4.86e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRArVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18209   1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENESQS-VFQLDFCEPDAFENVLNYIYSS 79


                ..
gi 23397572  91 WL 92
Cdd:cd18209  80 SL 81
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-122 5.87e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 57.17  E-value: 5.87e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFkSHTQESRARVIHLHVP-SAAGLQRLLDFIYT 89
Cdd:cd18331   7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIF-TDQLKCNLSVINLDPEiNPEGFNILLDFMYT 85

                        90       100       110
                ....*....|....*....|....*....|...
gi 23397572  90 AWLSLSMDTVEDTLEAASYLQVTEALGLCGRYL 122
Cdd:cd18331  86 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-130 6.41e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 56.90  E-value: 6.41e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAW---LSLSMDTVEDTLE 104
Cdd:cd18297  12 MSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGvesLDVAQDDALELLR 91

                        90       100
                ....*....|....*....|....*.
gi 23397572 105 AASYLQVTEALGLCGRYLERQLAPEN 130
Cdd:cd18297  92 AASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-112 6.42e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 56.76  E-value: 6.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQesrarVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18219   4 YSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVAGQ-----VVELNFIRADIFAEILNYIYSS 78

                        90       100
                ....*....|....*....|...
gi 23397572  91 WL-SLSMDTVEDTLEAASYLQVT 112
Cdd:cd18219  79 KIvRVRSDLLEELIKSGQLLGVK 101
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 28-109 7.56e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 56.72  E-value: 7.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAA- 106
Cdd:cd18352  13 LSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAAd 92


                ...
gi 23397572 107 SYL 109
Cdd:cd18352  93 QYL 95
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-117 9.72e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 56.35  E-value: 9.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  29 CDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLhvpSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASY 108
Cdd:cd18226  23 CDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTDAVTLDHV---SYSVFQHLLEFLYTSEFFVYENEIPLVLEAAKF 99


                ....*....
gi 23397572 109 LQVTEALGL 117
Cdd:cd18226 100 LDIIDAVKL 108
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-119 1.05e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 56.52  E-value: 1.05e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  19 YQALRAEGFLCDVTLETEGSEFPAHRSLLaCSSDYFRALFKSHTQESRARVIHLHVP----SAAGLQRLLDFIYTAWLSL 94
Cdd:cd18305   6 YQTLFLNGENSDITICALGREWKLHKIYL-CQSGYFASMFSGSWKESKETVINLEIPddniTVEALNVVFGSLYRDEIEI 84

                        90       100
                ....*....|....*....|....*
gi 23397572  95 SMDTVEDTLEAASYLQVTEALGLCG 119
Cdd:cd18305  85 KPSRVVSILAAATLLQLDGLIQQCS 109
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-121 1.69e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 55.19  E-value: 1.69e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  29 CDVTLETEGSEFPAHRSLLACSSDYFRALFKSH---TQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEA 105
Cdd:cd18307   2 CDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNdmkATDELSITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKG 81

                        90
                ....*....|....*.
gi 23397572 106 ASYLQVTEALGLCGRY 121
Cdd:cd18307  82 AKYFNIPRLKDHCVDF 97
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-120 1.92e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 55.81  E-value: 1.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESrARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18204   1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDS-SSVIEIDFLRSDIFEEVLNYMYTA 79

                        90       100       110
                ....*....|....*....|....*....|
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGR 120
Cdd:cd18204  80 KISVKKEDVNLMMSSGQILGIRFLDKLCSQ 109
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 30-89 3.62e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 54.22  E-value: 3.62e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIH--LHVPSAAG--LQRLLDFIYT 89
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVGCdvVHIEKVPPeiFEQLLQFIYT 83
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-123 4.02e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 54.95  E-value: 4.02e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  23 RAEGFLCDVTLETEGSEFPAHRSLLACSSDYF--RALFKshtqeSRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVE 100
Cdd:cd18227  20 RQQGQLCDISVVVQGHLFRAHKAVLAASSPYFcdQVLLK-----NSRRIVLPDVMNPRVFENILLSCYTGRLVLPAPEIV 94

                        90       100
                ....*....|....*....|...
gi 23397572 101 DTLEAASYLQVTEALGLCGRYLE 123
Cdd:cd18227  95 SYLTAASFLQMWHVVDKCTELLE 117
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-122 4.17e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 54.56  E-value: 4.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  29 CDVTLET--EGSEFPAHRSLLACSSDYFRALFKSHTQESRA--RVIHLHVPSAAGLQrLLDFIYTAWLSLSMDTVEDTLE 104
Cdd:cd18294  15 SDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKESTqsPLVLSDIEPEVFRA-VLEFIYTNCVTLSNHTVIEVLA 93

                        90
                ....*....|....*...
gi 23397572 105 AASYLQVTEALGLCGRYL 122
Cdd:cd18294  94 AAVEYGLDELRKLCERFI 111
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 30-118 6.50e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 53.50  E-value: 6.50e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYL 109
Cdd:cd18314   8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKY 87


                ....*....
gi 23397572 110 QVTEALGLC 118
Cdd:cd18314  88 QVPDLEKLC 96
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-130 7.33e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 54.07  E-value: 7.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYL 109
Cdd:cd18279  20 DCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADDLLAAADKY 99

                        90       100
                ....*....|....*....|.
gi 23397572 110 QVTEALGLCGRYLERQLAPEN 130
Cdd:cd18279 100 ALERLKVMCEDALCSNLSVEN 120
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-128 8.63e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 54.11  E-value: 8.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALF-KSHTQESRARVIHlhvpSAAGLQRLLDFIYT 89
Cdd:cd18203   8 HEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFlLNPSSELQVSLMH----SSRVVADLLLSCYT 83

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 23397572  90 AWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAP 128
Cdd:cd18203  84 GALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-124 9.02e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 53.92  E-value: 9.02e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  23 RAEGFLCDVTLETEGSEFPAHRSLLACSSDYFR-ALFKSHTQESRARVIhlhvpSAAGLQRLLDFIYTAWLSLSMDTVED 101
Cdd:cd18208  20 RNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQdKLLLGYSDIEIPSVV-----SVQSVQKLIDFMYSGVLRVSQSEALQ 94

                        90       100
                ....*....|....*....|...
gi 23397572 102 TLEAASYLQVTEALGLCGRYLER 124
Cdd:cd18208  95 ILTAASILQIKTVIDECTRIVSQ 117
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 20-101 1.03e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 53.79  E-value: 1.03e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  20 QALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVI-HLHVPSAAgLQRLLDFIYTAWLSLSMDT 98
Cdd:cd18295  11 RRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLkHPLVNPDA-FRALLQYLYTGRLEIHVDD 89


                ...
gi 23397572  99 VED 101
Cdd:cd18295  90 VED 92
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 29-130 1.10e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 53.93  E-value: 1.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  29 CDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHL--HVPSAAGLQRLLDFIYTAwlSLSMDTvEDTLE-- 104
Cdd:cd18309  21 CDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIgeMVPSRQAFDSLLRYIYYG--DVTMPP-EDSLYlf 97

                        90       100       110
                ....*....|....*....|....*....|....
gi 23397572 105 AASY--------LQvtealGLCGRYLERQLAPEN 130
Cdd:cd18309  98 SAPYfygftnnrLQ-----AYCKQNLEMNVSFEN 126
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-110 1.19e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 52.43  E-value: 1.19e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23397572  36 EGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQ 110
Cdd:cd18320   9 EEQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGLSARGFRIMLRVLAGERPILNGEEILQAIECAAFLQ 83
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-122 1.19e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 53.31  E-value: 1.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  12 GGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYF--RALFKSHTqesraRVIHLHVPSAAGLQRLLDFIYT 89
Cdd:cd18210   5 TSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFhdQVLLKNMS-----SISLPGVMDPGAFESVLASAYT 79

                        90       100       110
                ....*....|....*....|....*....|...
gi 23397572  90 AWLSLSMDTVEDTLEAASYLQVTEALGLCGRYL 122
Cdd:cd18210  80 GKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 30-106 2.13e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 52.68  E-value: 2.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRAR-----VIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLE 104
Cdd:cd18296  19 DVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLY 98


                ..
gi 23397572 105 AA 106
Cdd:cd18296  99 VA 100
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 26-89 2.15e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 52.75  E-value: 2.15e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 23397572  26 GFLCDVTLETE-GSEFPAHRSLLACSSDYFRALFKSHTQE-SRARVIHLHVPSAAgLQRLLDFIYT 89
Cdd:cd18302   3 SDLYDVTIVSEdGKEFPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTMPIPSDI-LEIILDYLYT 67
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-130 4.41e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 52.27  E-value: 4.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWL----SLSMDTveDTLEA 105
Cdd:cd18344  25 DCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAphlhSHSMAC--DVLAA 102

                        90       100
                ....*....|....*....|....*
gi 23397572 106 ASYLQVTEALGLCGRYLERQLAPEN 130
Cdd:cd18344 103 ADKYGLEGLKVLCEDALCRNLSVEN 127
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-107 5.49e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 51.56  E-value: 5.49e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23397572  29 CDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTawlslsmDTVEDTLEAAS 107
Cdd:cd18280  15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYK-------DELPDDVEPAG 86
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 30-122 6.83e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 50.67  E-value: 6.83e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSE-FPAHRSLLACSSDYFRALFKSHTqesrarVIHL--HVpSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAA 106
Cdd:cd18299  14 DVVFILQGGVrIFAHRIVLAAASSVFADLFLMMT------VVTLdsDI-TPEAFRRVLEFLYTGVLDENEDDLKELKDAA 86

                        90
                ....*....|....*.
gi 23397572 107 SYLQVTEALGLCGRYL 122
Cdd:cd18299  87 ELLELFDLVMMCTNVL 102
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-130 7.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 51.54  E-value: 7.22e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAwLSLSMDTVEDTLEAASYL 109
Cdd:cd18343  23 DCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTG-KAPNLDKMADNLLAAADK 101

                        90       100
                ....*....|....*....|..
gi 23397572 110 QVTEALG-LCGRYLERQLAPEN 130
Cdd:cd18343 102 YALERLKvMCEEALCNNLSVEN 123
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-124 2.15e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 49.86  E-value: 2.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  14 ALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFR-ALFKSHTQESRARVIhlhvpSAAGLQRLLDFIYTAWL 92
Cdd:cd18229   4 SLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHdKLLLGHSEIEVPPVV-----PAQTVRQLVEFMYSGSL 78

                        90       100       110
                ....*....|....*....|....*....|..
gi 23397572  93 SLSMDTVEDTLEAASYLQVTEALGLCGRYLER 124
Cdd:cd18229  79 VVAQSEALQILTAASILQIKTVIDECTQIISQ 110
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-128 3.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 49.44  E-value: 3.32e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKshTQESRARVIHLHVPSAAGLQRLLDfIYTA 90
Cdd:cd18214   8 YGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFL--LNDSREVQISILQNSEVGRQLLLS-CYTG 84

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAP 128
Cdd:cd18214  85 VLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 122
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 15-117 4.85e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 48.74  E-value: 4.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  15 LLTGYQALRAEGFLCDVTLET-EGSEFPAHRSLLACSSDYFRALFKSHTQESRArvihLHVPS---AAGLQRLLDFIYTA 90
Cdd:cd18311   1 FLQRLQNLFNKTEYCDLTLQFrDNEQLKVHRLVLSACTDYFNVLEQTCEIVDDT----LIMPNelqADAVVPVINFMYTG 76

                        90       100
                ....*....|....*....|....*..
gi 23397572  91 WLSLSMDTVEDTLEAASYLQVTEALGL 117
Cdd:cd18311  77 QLEFEEKSYGKLLRTAKELNMTVLLKL 103
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-115 1.03e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 47.94  E-value: 1.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFK-SHTQESRARVIHlhvpSAAGLQRLLDFIYT 89
Cdd:cd18197   8 QGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLlNQSKQVRITILQ----SAEVGRKLLLSCYT 83

                        90       100       110
                ....*....|....*....|....*....|...
gi 23397572  90 AWLSLSMDTVEDTLEAASYLQV-------TEAL 115
Cdd:cd18197  84 GALEVKKKELLKYLTAASYLQMvhivekcTEAL 116
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-130 1.19e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 47.92  E-value: 1.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSlSMDTVEDTLEAASYL 109
Cdd:cd18345  20 DVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAP-NLDKMADDLLAAADK 98

                        90       100
                ....*....|....*....|..
gi 23397572 110 QVTEALG-LCGRYLERQLAPEN 130
Cdd:cd18345  99 YALERLKvMCEEALCSNLSVEN 120
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 23-117 1.25e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 47.33  E-value: 1.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  23 RAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAG-LQRLLDFIYTAWLSLSMDTVED 101
Cdd:cd18312   4 RDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPSEIELNDFPGGAEaFELVAKFCYGMPINLTATNVVG 83

                        90
                ....*....|....*.
gi 23397572 102 TLEAASYLQVTEALGL 117
Cdd:cd18312  84 LRCAAEYLEMTESGNL 99
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-130 1.54e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 47.82  E-value: 1.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  28 LCDVTL----ETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQrLLDFIYTAWLSLSMDTVEDTL 103
Cdd:cd18281  22 LSDVHFivgkGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELPDVEPAAFLA-LLRFLYSDEVQIGPETVMTTL 100

                        90       100
                ....*....|....*....|....*..
gi 23397572 104 EAASYLQVTEALGLCGRYLERQLAPEN 130
Cdd:cd18281 101 YTAKKYAVPALESACVEFLKKNLSSDN 127
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 24-100 4.69e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 46.11  E-value: 4.69e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23397572  24 AEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLS--LSMDTVE 100
Cdd:cd18358  16 SKGTFSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSptADLDPLE 94
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-64 6.25e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 45.75  E-value: 6.25e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQE 64
Cdd:cd18193   4 HGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTSE 57
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-111 6.82e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 45.58  E-value: 6.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  23 RAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQ-ESRARVIHLHVpSAAGLQRLLDFIYTAWLSLSMDTVED 101
Cdd:cd18192  16 REWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHtTAQLNLSNMKI-SAECFDLILQFMYLGKIMTAPSDFEQ 94

                        90
                ....*....|
gi 23397572 102 TLEAASYLQV 111
Cdd:cd18192  95 LKVAMNYLQL 104
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 11-109 1.11e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 44.51  E-value: 1.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSdyfrALFKSHTQESRARVIHLH-VPSAAGLQRLLDFIYT 89
Cdd:cd18262   1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVS----SLFRERLLGSNGPLPPLSlEVTPVGWEAVLTFAYT 76

                        90       100
                ....*....|....*....|
gi 23397572  90 AWLSLSMDTVEDTLEAASYL 109
Cdd:cd18262  77 GVLGRNPATVGDILVAAEAL 96
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-126 1.27e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 44.59  E-value: 1.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  41 PAHRSLLACSSDYFRALFKSHTQESRARVihlHVPSA--AGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLC 118
Cdd:cd18349  25 PAHKYVLAVGSSVFYAMFYGDLAEVKSEI---HIPDVepAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKAC 101


                ....*...
gi 23397572 119 GRYLERQL 126
Cdd:cd18349 102 VNFLETSL 109
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-130 1.76e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 44.71  E-value: 1.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSlSMDTVEDTLEAASYL 109
Cdd:cd18342  24 DCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAP-NLDKMADDLLAAADK 102

                        90       100
                ....*....|....*....|..
gi 23397572 110 QVTEALG-LCGRYLERQLAPEN 130
Cdd:cd18342 103 YALERLKvMCEDALCSNLSVEN 124
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 25-90 3.25e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 43.11  E-value: 3.25e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23397572  25 EGFLCDVTLETEGSEFPAHRS-LLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTA 90
Cdd:cd18285  12 EELHTDVTFYVGSTLFKAHKAiLLARVPEFFSHIIGKLSSLEDQEPINIENLEASEFKTFLRQVYTS 78
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-64 6.05e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 42.96  E-value: 6.05e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 23397572  10 AHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQE 64
Cdd:cd18213   3 SHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSE 57
Kelch_6 pfam13964
Kelch motif;
357-415 7.49e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.40  E-value: 7.49e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 23397572   357 LGHSVCTAGNFLFVLGGESPSGSASSpladdsrvvtaQVHRYDPRFHAWTEVPAMREAR 415
Cdd:pfam13964   3 TFHSVVSVGGYIYVFGGYTNASPALN-----------KLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-132 8.23e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 42.70  E-value: 8.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  41 PAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQrLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGR 120
Cdd:cd18348  38 PGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLA-MLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVN 116

                        90
                ....*....|..
gi 23397572 121 YLERQLAPENCC 132
Cdd:cd18348 117 FLETSLSAKNAC 128
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-111 9.90e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 42.12  E-value: 9.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  15 LLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESrarvIHLHVPSAAGLQRLLDFIYTAWLSL 94
Cdd:cd18225  10 LLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTIS----IDASVVSPEEFALLLEMVYTGKLPP 85

                        90
                ....*....|....*..
gi 23397572  95 SMDTVEDTLEAASYLQV 111
Cdd:cd18225  86 GKHNFTKIISVADSLQM 102
PHA02713 PHA02713
hypothetical protein; Provisional
 11-133 1.02e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 45.39  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   11 HGGALLTGYQALRAEGFLCDVTLET-EGSEFPAHRSLLACSSDYFRALFKSH--TQESRARViHLHVPSAAGLQRLLDFI 87
Cdd:PHA02713   8 HNRRVVSNISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTTPmiIRDLVTRV-NLQMFDKDAVKNIVQYL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 23397572   88 YTAWLSlSMDTVeDTLEAASYLQVTEALGLCGRYLERQLAPENCCF 133
Cdd:PHA02713  87 YNRHIS-SMNVI-DVLKCADYLLIDDLVTDCESYIKDYTNHDTCIY 130
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 30-101 1.67e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 40.78  E-value: 1.67e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFkSHTQESRARVIhLHVPSA----AGLQRLLDFIYTAWLSLSMDTVED 101
Cdd:cd18283   4 DVDLVFQGTCFPVHRAILSARCPFFRDLL-SSSPGYGAEIP-VDLPTAgidvPMFSALLRYLYTGEFGSEDSRSQN 77
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
335-382 1.98e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 43.61  E-value: 1.98e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 23397572 335 NVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASS 382
Cdd:COG3055 221 EVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVRTP 268
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 131-236 1.99e-04

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 40.99  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572   131 CCFAANVAARFGLAHTLDAAERCIVSHLQELLARgagpAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLRQEPTt 210
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKS----EEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVE- 75

                          90       100
                  ....*....|....*....|....*.
gi 23397572   211 ERLAHCTELLERVRFGLVPADVLRRV 236
Cdd:pfam07707  76 RRKKHLPELLSAVRLPLLSPQYLLNL 101
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 28-126 2.20e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 40.99  E-value: 2.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYT-AWLSLSMDTVEDTLEAA 106
Cdd:cd18360  10 LADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTdSCCPASILQAMALLICA 89

                        90       100
                ....*....|....*....|
gi 23397572 107 SYLQVTEALGLCGRYLERQL 126
Cdd:cd18360  90 EMYQVSRLQHICELYIITQL 109
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-126 3.12e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 40.46  E-value: 3.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  41 PAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQrLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGR 120
Cdd:cd18282  24 PAHKYVLATGSSVFYAMFYGGLAENKNEIEIPDVEPAAFLN-LLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQ 102


                ....*.
gi 23397572 121 YLERQL 126
Cdd:cd18282 103 FLETSL 108
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 355-412 3.87e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.36  E-value: 3.87e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 23397572   355 PLLGHSVCTAGNFLFVLGGESPSGSASSpladdsrvvtaqVHRYDPRFHAWTEVPAMR 412
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNS------------VEVYDPETNTWSKLPSMP 46
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 179-229 8.70e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 39.05  E-value: 8.70e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 23397572 179 LRAVLGAPDVARVPEARLLGLALAWLRQEPttERLAHCTELLERVRFGLVP 229
Cdd:cd18475  51 LCQYLSSNQVQHECEHDLLQAALQWLTQSP--ERENEAYQVLSNIHFPLIP 99
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 515-558 1.12e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 23397572   515 ARFGHHMAVLRGAVFAFLGRY--EPFSEIERYDPGADQWTRLRPLP 558
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDgnQSLNSVEVYDPETNTWSKLPSMP 46
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 24-97 1.39e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 39.22  E-value: 1.39e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23397572  24 AEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMD 97
Cdd:cd18359  16 AKGTFSDVTFMLDDGTISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQFSSSPD 89
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-118 1.46e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 38.77  E-value: 1.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSmdtVEDTLE----A 105
Cdd:cd18298  14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLP---PEDAIGlldlA 90

                        90
                ....*....|...
gi 23397572 106 ASYLQvTEALGLC 118
Cdd:cd18298  91 NSYCE-ERLKKLC 102
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-130 1.58e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 39.27  E-value: 1.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  41 PAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQrLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGR 120
Cdd:cd18346  45 PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLA-LLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVE 123

                        90
                ....*....|
gi 23397572 121 YLERQLAPEN 130
Cdd:cd18346 124 FLTKHLRADN 133
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-131 2.06e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 38.46  E-value: 2.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAaglqrLLDFIYTAWLSLSMDTVE--DTLEAAS 107
Cdd:cd18303  20 DITIKLADKSIPAHKFVLAARSEKWSNENLASTNELDLSDISYEVVLA-----LLRWLYTDELDLTLDDEFllELMKAAK 94

                        90       100
                ....*....|....*....|....
gi 23397572 108 YLQVTEALGLCGRYLERQLAPENC 131
Cdd:cd18303  95 RFQLTDLVERCERALMSSVNVDNC 118
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 129-228 2.31e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 37.93  E-value: 2.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 129 ENCCFAANVAARFGLAHTLDAAERCIVSHLQELlargAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLrqEP 208
Cdd:cd18470   4 ENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEF----SETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWL--DF 77

                        90       100
                ....*....|....*....|
gi 23397572 209 TTERLAHCTELLERVRFGLV 228
Cdd:cd18470  78 DQKRVKYAADLLSNIRFGTI 97
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 30-107 2.58e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 37.11  E-value: 2.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHL--HVPSAAGLQRLLDFIYTAWLSLS-MDTVEDTLEAA 106
Cdd:cd18190   1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFeeNGISIEAMRAVIDFSVTGRLDLFsVENVHEVLELA 80


                .
gi 23397572 107 S 107
Cdd:cd18190  81 S 81
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-111 3.30e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 38.29  E-value: 3.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHT-QESRA-RVIHLHVPSAAGLQRLLDFIY---TAWLSLSMDTVEDT 102
Cdd:cd18350  24 MSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSeQESQGsKTIEISDIKYHIFQMLMQYLYyggTESMEIPIADVLEL 103


                ....*....
gi 23397572 103 LEAASYLQV 111
Cdd:cd18350 104 LSAASLFQL 112
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-89 5.81e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 37.24  E-value: 5.81e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYT 89
Cdd:cd18353  22 DLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLYT 81
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 129-225 6.47e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 36.63  E-value: 6.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572 129 ENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGagpaGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLRQEP 208
Cdd:cd18449   4 ENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTG----DFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHED 79

                        90
                ....*....|....*..
gi 23397572 209 ttERLAHCTELLERVRF 225
Cdd:cd18449  80 --DRMQFAAKLMENIRF 94
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-130 6.60e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 37.36  E-value: 6.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397572  41 PAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQrLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGR 120
Cdd:cd18347  39 PAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLA-LLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVE 117

                        90
                ....*....|
gi 23397572 121 YLERQLAPEN 130
Cdd:cd18347 118 FLKKNLRADN 127
Kelch smart00612
Kelch domain;
441-472 8.06e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.84  E-value: 8.06e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 23397572    441 ASVEMYDLRRDRWTAAGALPRALHGHAGAVGD 472
Cdd:smart00612  15 KSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
Kelch smart00612
Kelch domain;
536-571 8.23e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.84  E-value: 8.23e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 23397572    536 EPFSEIERYDPGADQWTRLRPLPYDRFCYGLAVVEE 571
Cdd:smart00612  12 QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-90 9.11e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 36.30  E-value: 9.11e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23397572  30 DVTLETEG-SEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLH-VPSAAgLQRLLDFIYTA 90
Cdd:cd18313   3 DVEIETDNnSHIPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILgVPCDA-VRVFIRFLYSS 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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