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Conserved domains on  [gi|229891788|sp|B9TQX2|]
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RecName: Full=Unique cartilage matrix-associated protein; Contains: RecName: Full=Unique cartilage matrix-associated protein C-terminal fragment; Short=Ucma-C; AltName: Full=Gla-rich protein; Short=GRP; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UCMA super family cl25314
Unique cartilage matrix associated protein; UCMA is a secreted cartilage-specific protein ...
 25-129 6.79e-29

Unique cartilage matrix associated protein; UCMA is a secreted cartilage-specific protein located in chromosome 2 that is predominantly expressed in resting chondrocytes. It is secreted into the extracellular matrix as an uncleaved precursor and shows the same restricted distribution pattern in cartilage as UCMA mRNA. This protein is proteolytically processed and contains tyrosine sulfates. It seems to be to be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of foetal cartilage.


The actual alignment was detected with superfamily member pfam17085:

Pssm-ID: 293690  Cd Length: 134  Bit Score: 102.37  E-value: 6.79e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229891788   25 DSAAVRDDSKAGHPK--GPARQVFVPESEASNFFKRRSRRSPRSYAELQAEQRVKIAANERWREYNEEQRNEHENYAEEA 102
Cdd:pfam17085  25 DSASVSDKRDAVNPAseGAKRKIFMQESDASNFFKRRGKRSPKSQDEINAENRQRLAADERRREYYEEQRNEFENYVEEE 104

                          90       100
                  ....*....|....*....|....*..
gi 229891788  103 RDESDERSRETHEQIREYHYDGLYPRY 129
Cdd:pfam17085 105 NDEQEERSREKTEQWRQWHYDGLDPSY 131
 
Name Accession Description Interval E-value
UCMA pfam17085
Unique cartilage matrix associated protein; UCMA is a secreted cartilage-specific protein ...
 25-129 6.79e-29

Unique cartilage matrix associated protein; UCMA is a secreted cartilage-specific protein located in chromosome 2 that is predominantly expressed in resting chondrocytes. It is secreted into the extracellular matrix as an uncleaved precursor and shows the same restricted distribution pattern in cartilage as UCMA mRNA. This protein is proteolytically processed and contains tyrosine sulfates. It seems to be to be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of foetal cartilage.


Pssm-ID: 293690  Cd Length: 134  Bit Score: 102.37  E-value: 6.79e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229891788   25 DSAAVRDDSKAGHPK--GPARQVFVPESEASNFFKRRSRRSPRSYAELQAEQRVKIAANERWREYNEEQRNEHENYAEEA 102
Cdd:pfam17085  25 DSASVSDKRDAVNPAseGAKRKIFMQESDASNFFKRRGKRSPKSQDEINAENRQRLAADERRREYYEEQRNEFENYVEEE 104

                          90       100
                  ....*....|....*....|....*..
gi 229891788  103 RDESDERSRETHEQIREYHYDGLYPRY 129
Cdd:pfam17085 105 NDEQEERSREKTEQWRQWHYDGLDPSY 131
 
Name Accession Description Interval E-value
UCMA pfam17085
Unique cartilage matrix associated protein; UCMA is a secreted cartilage-specific protein ...
 25-129 6.79e-29

Unique cartilage matrix associated protein; UCMA is a secreted cartilage-specific protein located in chromosome 2 that is predominantly expressed in resting chondrocytes. It is secreted into the extracellular matrix as an uncleaved precursor and shows the same restricted distribution pattern in cartilage as UCMA mRNA. This protein is proteolytically processed and contains tyrosine sulfates. It seems to be to be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of foetal cartilage.


Pssm-ID: 293690  Cd Length: 134  Bit Score: 102.37  E-value: 6.79e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229891788   25 DSAAVRDDSKAGHPK--GPARQVFVPESEASNFFKRRSRRSPRSYAELQAEQRVKIAANERWREYNEEQRNEHENYAEEA 102
Cdd:pfam17085  25 DSASVSDKRDAVNPAseGAKRKIFMQESDASNFFKRRGKRSPKSQDEINAENRQRLAADERRREYYEEQRNEFENYVEEE 104

                          90       100
                  ....*....|....*....|....*..
gi 229891788  103 RDESDERSRETHEQIREYHYDGLYPRY 129
Cdd:pfam17085 105 NDEQEERSREKTEQWRQWHYDGLDPSY 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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