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Conserved domains on  [gi|2290794|gb|AAB65169|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Arizelocichla masukuensis roehli]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 super family cl33352
NADH dehydrogenase subunit 2; Provisional
 1-93 9.63e-47

NADH dehydrogenase subunit 2; Provisional


The actual alignment was detected with superfamily member MTH00112:

Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 151.90  E-value: 9.63e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290794     1 MNPQANLIFVTSLLLGTTITISSNHWITAWAGLEINTLAILPLISKSHHPRAIEAATKYFLTQATASTLLLFSSMTNAWY 80
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80

                         90
                 ....*....|...
gi 2290794    81 TGQWDITQ**YPM 93
Cdd:MTH00112  81 TGQWDITQLTNPT 93
 
Name Accession Description Interval E-value
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-93 9.63e-47

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 151.90  E-value: 9.63e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290794     1 MNPQANLIFVTSLLLGTTITISSNHWITAWAGLEINTLAILPLISKSHHPRAIEAATKYFLTQATASTLLLFSSMTNAWY 80
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80

                         90
                 ....*....|...
gi 2290794    81 TGQWDITQ**YPM 93
Cdd:MTH00112  81 TGQWDITQLTNPT 93
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 14-72 5.50e-08

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 48.19  E-value: 5.50e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290794   14 LLGTTITISSNHWITAWAGLEINTLAILPLIS-KSHHPRAIEAATKYFLTQATASTLLLF 72
Cdd:COG1007 112 TLGMMLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLY 171
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-88 1.22e-05

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 41.53  E-value: 1.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2290794     23 SNHWITAWAGLEINTLAILPLI-SKSHHPRAIEAATKYFLTQATASTLLLFSSMTNAWYTGQWDITQ 88
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIgYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDE 67
 
Name Accession Description Interval E-value
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-93 9.63e-47

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 151.90  E-value: 9.63e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290794     1 MNPQANLIFVTSLLLGTTITISSNHWITAWAGLEINTLAILPLISKSHHPRAIEAATKYFLTQATASTLLLFSSMTNAWY 80
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80

                         90
                 ....*....|...
gi 2290794    81 TGQWDITQ**YPM 93
Cdd:MTH00112  81 TGQWDITQLTNPT 93
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-93 1.28e-42

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 141.48  E-value: 1.28e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290794     1 MNPQANLIFVTSLLLGTTITISSNHWITAWAGLEINTLAILPLISKSHHPRAIEAATKYFLTQATASTLLLFSSMTNAWY 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                         90
                 ....*....|...
gi 2290794    81 TGQWDITQ**YPM 93
Cdd:MTH00135  81 TGQWDIQQMSHPL 93
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-93 1.37e-41

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 138.90  E-value: 1.37e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290794     1 MNPQANLIFVTSLLLGTTITISSNHWITAWAGLEINTLAILPLISKSHHPRAIEAATKYFLTQATASTLLLFSSMTNAWY 80
Cdd:MTH00070   1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80

                         90
                 ....*....|...
gi 2290794    81 TGQWDITQ**YPM 93
Cdd:MTH00070  81 TGEWTIMNMQTPL 93
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-93 1.08e-34

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 120.72  E-value: 1.08e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290794     1 MNPQANLIFVTSLLLGTTITISSNHWITAWAGLEINTLAILPLISKSHHPRAIEAATKYFLTQATASTLLLFSSMTNAWY 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90
                 ....*....|...
gi 2290794    81 TGQWDITQ**YPM 93
Cdd:MTH00105  81 SGQWTITKLTNPT 93
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-93 1.06e-29

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 107.75  E-value: 1.06e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290794     1 MNPQANLIFVTSLLLGTTITISSNHWITAWAGLEINTLAILPLISKSHHPRAIEAATKYFLTQATASTLLLFSSMTNAWY 80
Cdd:MTH00200   1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWT 80

                         90
                 ....*....|...
gi 2290794    81 TGQWDITQ**YPM 93
Cdd:MTH00200  81 SGQWGISEMLGPL 93
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-88 7.47e-25

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 95.00  E-value: 7.47e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290794     1 MNPQANLIFVTSLLLGTTITISSNHWITAWAGLEINTLAILPLISKSHHPRAIEAATKYFLTQATASTLLLFSSMTNAWY 80
Cdd:MTH00041   1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80


                 ....*...
gi 2290794    81 TGQWDITQ 88
Cdd:MTH00041  81 SGSWSING 88
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-77 4.50e-18

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 76.40  E-value: 4.50e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2290794     1 MNPQANLIFVTSLLLGTTITISSNHWITAWAGLEINTLAILPLISKSHHPRAIEAATKYFLTQATASTLLLFSSMTN 77
Cdd:MTH00160   2 MMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILN 78
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 5-86 8.27e-17

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 73.00  E-value: 8.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290794     5 ANLIFVTSLLLGTTITISSNHWITAWAGLEINTLAILPLISKSHHPRAIEAATKYFLTQATASTLLLFSSMTNAWYTGQW 84
Cdd:MTH00144   5 SNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSW 84


                 ..
gi 2290794    85 DI 86
Cdd:MTH00144  85 FS 86
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 7-74 4.47e-11

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 57.10  E-value: 4.47e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2290794     7 LIFVTSLLLGTTITISSNHWITAWAGLEINTLAILPLISKSHHPRAIEAATKYFLTQATASTLLLFSS 74
Cdd:MTH00011   9 FLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGM 76
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 8-75 2.72e-09

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 51.98  E-value: 2.72e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2290794     8 IFVTSLLLGTTITISSNHWITAWAGLEINTLAILPLISKSHHPRAIEAATKYFLTQATASTLLLFSSM 75
Cdd:MTH00197   2 LFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGS 69
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 14-72 5.50e-08

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 48.19  E-value: 5.50e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290794   14 LLGTTITISSNHWITAWAGLEINTLAILPLIS-KSHHPRAIEAATKYFLTQATASTLLLF 72
Cdd:COG1007 112 TLGMMLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLY 171
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
14-72 1.37e-06

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 44.43  E-value: 1.37e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290794    14 LLGTTITISSNHWITAWAGLEINTLAILPLIS-KSHHPRAIEAATKYFLTQATASTLLLF 72
Cdd:PRK05777 113 LLGMMVMVSANDLLTLFLGLELLSLPLYALAAlRRDRRRSLEAAIKYFVLGALASGFLLY 172
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-88 1.22e-05

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 41.53  E-value: 1.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2290794     23 SNHWITAWAGLEINTLAILPLI-SKSHHPRAIEAATKYFLTQATASTLLLFSSMTNAWYTGQWDITQ 88
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIgYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDE 67
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 13-72 2.60e-04

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 38.09  E-value: 2.60e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2290794    13 LLLGTTITISSNHWITAWAGLEINTLAILPLI-SKSHHPRAIEAATKYFLTQATASTLLLF 72
Cdd:MTH00196   2 VALGILCLISSSNWLSVYLAIELQTLSLFILIaQNRGSGYSAEAGLKYFVLGALSSGLFLF 62
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 8-72 7.52e-04

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 36.53  E-value: 7.52e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2290794     8 IFVTSLLLGTTITISSNHWITAWAGLEINTLAILPLIS-KSHHPRAIEAATKYFLTQATASTLLLF 72
Cdd:MTH00199 101 ILILIVALGSLLLVSSINWLSIYLAIELQTLTLFILVAlKRDSAYSTEAGLKYFVLGAVSSGLFLF 166
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 8-74 6.81e-03

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 33.75  E-value: 6.81e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2290794     8 IFVTSLLLgttiTISSNHWITAWAGLEINTLAILPLISKSHHPRAIEAATKYFL------TQATASTLLLFSS 74
Cdd:PRK06458 116 LFLFTMLL----ALTSNNLGLMWVAIEATTLSSALLVGIYRTRASLEAAWKYIIicsvgvAFALFGTILVYAN 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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