|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
34-468 |
0e+00 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 526.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 34 ELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVG 113
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 114 VILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVA 193
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 194 ANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCME 273
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 274 WWAYEVGSFLSGIL-GMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSV 352
Cdd:cd13132 241 WWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 353 LLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATT 432
Cdd:cd13132 321 LLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVLG 400
|
410 420 430
....*....|....*....|....*....|....*.
gi 22907060 433 LGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQ 468
Cdd:cd13132 401 LGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
35-456 |
1.50e-70 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 233.11 E-value: 1.50e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 35 LRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:COG0534 7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 115 ILQRSALVLLLCCFPCWAL-FLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVA 193
Cdd:COG0534 86 VLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 194 ANLVNALANYLFLHQLHLGVIGSALANLISQY-TLALLLFLYILGKKLHQATWGGWSLEcLQDWASFLRLAIPSMLMLCM 272
Cdd:COG0534 166 GNVLNIVLDPLLIFGGGLGVAGAALATVISQAvSALLLLYYLFRKRSLLRLRLRDLRPD-RKILKRILRIGLPAGLQQLA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 273 EWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSV 352
Cdd:COG0534 245 ESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLAL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 353 LLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFaTT 432
Cdd:COG0534 325 LLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LG 403
|
410 420
....*....|....*....|....
gi 22907060 433 LGVMGLWSGIIICTVFQAVCFLGF 456
Cdd:COG0534 404 LGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
34-463 |
1.51e-70 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 233.16 E-value: 1.51e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 34 ELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKHVG 113
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 114 VILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVA 193
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 194 ANLVNALANYLFLHQL----HLGVIGSALANLISQY-TLALLLFLYILGKKLHQ-ATWGGWSLECLQDWASFLRLAIPSM 267
Cdd:cd13131 160 ALVLNIPLNYVLIFGKfglpALGGAGAGLATAIVYWlMFLALAFYIRRHKRFRRyRLFARFWRPDWARLKELLRLGLPIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 268 LMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFA 347
Cdd:cd13131 240 LTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 348 VAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIAL 427
Cdd:cd13131 320 ALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLGYLL 399
|
410 420 430
....*....|....*....|....*....|....*.
gi 22907060 428 MFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWK 463
Cdd:cd13131 400 AFTTGLGAFGVWIGLIIGLALAAILLLWRFRRLQRR 435
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
44-383 |
1.18e-60 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 204.40 E-value: 1.18e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 44 PAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAiAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVL 123
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 124 LLCCFPCWALFLNTQHILLLFRQ-DPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALAN 202
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 203 YLFLHQLH--LGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVG 280
Cdd:TIGR00797 160 YILIFGKFgfLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 281 SFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDH 360
Cdd:TIGR00797 240 ALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREF 319
|
330 340
....*....|....*....|...
gi 22907060 361 VGYIFTTDRDIINLVAQVVPIYA 383
Cdd:TIGR00797 320 IARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
42-458 |
6.75e-55 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 191.38 E-value: 6.75e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 42 AGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINvTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSAL 121
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIA-LLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 122 VLLLCCFPCWALFL-NTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNAL 200
Cdd:cd12082 80 LAILLGLLLAALLLfFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 201 ANYLFLHQL---HLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAY 277
Cdd:cd12082 160 LDPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 278 EVGSFL-SGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLS 356
Cdd:cd12082 240 LIIVAIvAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 357 CKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFAtTLGVM 436
Cdd:cd12082 320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYL-GLGLY 398
|
410 420
....*....|....*....|..
gi 22907060 437 GLWSGIIICTVFQAVCFLGFII 458
Cdd:cd12082 399 GIWLALVISLILAALVLLLFFR 420
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
36-463 |
1.62e-51 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 182.33 E-value: 1.62e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 36 RALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVsVGFGLSSACDTLISQTYGSQNLKHVGVI 115
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLV-LNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 116 LQRSALVLLLCCFP-CWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAA 194
Cdd:cd13137 80 LGQSLLLALLLSLPlALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 195 NLVNALANYLF----LHQLHLGVIGSALANLISQYTLALLLFLYILGKKLH-QATWGGWSLEcLQDWASFLRLAIPSMLM 269
Cdd:cd13137 160 NVLNIVLDYVLifglWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPiKISFKGFRLD-RKIIKKLLRIGLPAGLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 270 LCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVA 349
Cdd:cd13137 239 QLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 350 FSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMF 429
Cdd:cd13137 319 LGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGF 398
|
410 420 430
....*....|....*....|....*....|....
gi 22907060 430 ATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWK 463
Cdd:cd13137 399 VLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-462 |
8.69e-46 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 166.93 E-value: 8.69e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 35 LRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAiAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13133 4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 115 ILQRSALVLLLCCFPCWAL-FLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLY-MLQVKYLlnqGIVLPQIVTG- 191
Cdd:cd13133 83 VLWQGLYFSLLLAPLLALLsALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGaALRAFFS---GIGRTRVVMVa 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 192 -VAANLVNALANYLF----LHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQ--ATWGGWSLEcLQDWASFLRLAI 264
Cdd:cd13133 160 nLVMVVVNIVLDYALifgkLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRrfGLRRAWRFD-RELLRRILRLGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 265 PSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITV 344
Cdd:cd13133 239 PSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 345 LFAVAFSVLLLSCKDHVGYIFTTDRD---IINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGL 421
Cdd:cd13133 319 AYMLLLGILFLLFPELLLSIFTPGADfalIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLL 398
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 22907060 422 PIGIALMFAtTLGVMGLWSGIIICTVFQAVCFLGFIIQLNW 462
Cdd:cd13133 399 PPAYLLVVL-GAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
29-444 |
2.32e-41 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 155.36 E-value: 2.32e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 29 SAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAiAVINVTGVSVGFGLSSACDTLISQTYGSQN 108
Cdd:PRK01766 5 QKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIG-TSIWLPVILFGHGLLLALTPIVAQLNGAGR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 109 LKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQ-DPDVSRLTQTYVTIFIPALPATFLYmlQVKYLLNQGIVLPQ 187
Cdd:PRK01766 84 RERIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNlEPEVADIAVGYLHALLWGIPAYLLY--QVLRSFIDGLGKTK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 188 I--VTGVAANLVNALANYLFLHQL----HLGVIGSALANLISqYTLALLLFLYILGKKLHQAT---WGGWSLECLQDWAS 258
Cdd:PRK01766 162 PtmVIGFLGLLINIPLNYIFIYGKfgfpELGGVGCGVATAIV-YWVMFLAMLIYIKRARRFRDfrlFKGLYKPDWAVIKR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 259 FLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTV 338
Cdd:PRK01766 241 LLKLGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 339 SLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYV 418
Cdd:PRK01766 321 GLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWV 400
|
410 420
....*....|....*....|....*.
gi 22907060 419 VGLPIGIALMFATTLGVMGLWSGIII 444
Cdd:PRK01766 401 LGLPLGYILALTDPMGPFGFWIGLII 426
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-464 |
1.07e-40 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 153.04 E-value: 1.07e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 36 RALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVsVGFGLSSACDTLISQTYGSQNLKHVGVI 115
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLIL-IFSFISTGTSILIAQYLGAKDKKKARQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 116 LQRS-ALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAA 194
Cdd:cd13134 82 AGVAlLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 195 NLVNALANYLFLHQLH----LGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLml 270
Cdd:cd13134 162 NILNIVGNYLLIFGWFglpkLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLPSAG-- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 271 cmEWWAYEVGSFLS----GILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLF 346
Cdd:cd13134 240 --EELSYNLSQTVItafiARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 347 AVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIA 426
Cdd:cd13134 318 SLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYL 397
|
410 420 430
....*....|....*....|....*....|....*...
gi 22907060 427 LMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKK 464
Cdd:cd13134 398 LGIVLGLGLLGVWIAFAADEWVRGIIMLWRWRSGKWIK 435
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
35-463 |
2.00e-35 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 137.98 E-value: 2.00e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 35 LRALLVLAGPAFLVQLMVFLISFISSVFCGH-LGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKHVG 113
Cdd:cd13138 2 LKTLLLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLL-TAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 114 -------VILQRSALVLLLCCFPCwalflnTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYmlqvkYLLN---QGI 183
Cdd:cd13138 81 kavgtllVLFLILGIVLTILGLLF------APPILRLMNTPAEILELAVSYLRICFLGIPFIFGY-----NAYSailRGL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 184 ---VLPQIVTGVAAnLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHqatwGGWSLECLQ-DWASF 259
Cdd:cd13138 150 gdsKTPLYFVIIAC-VLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLP----FKLSLKDFRfDKEIL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 260 ---LRLAIPSMLMLCMewwayevgSFLSGIL--------GMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGD 328
Cdd:cd13138 225 keiLKIGLPSALQQSL--------VSISFLIinsivnsyGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGK 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 329 MEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVG 408
Cdd:cd13138 297 IERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFP 376
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 22907060 409 AIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWK 463
Cdd:cd13138 377 MIISILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-464 |
6.20e-35 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 136.94 E-value: 6.20e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 35 LRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVInVTGVSVGFGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13142 10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLI-FLFISLGGGLTVAGTALVAQYTGAGDYDKANK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 115 ILQRSALVLLLCCFPCWAL--FLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMlqVKYLLNQGI---VLPQIV 189
Cdd:cd13142 89 VAGQTFSFVIILSLILAVLgyILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFF--VFNSLLRGIgdtKTPMKI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 190 TGVAAnLVNALANYLFLHQL----HLGVIGSALANLISQYTLALLLFLYILGKKLHqatwGGWSLECLQ-DW---ASFLR 261
Cdd:cd13142 167 MFGSV-LLNVILDPLLIFGIgpfpGLGVAGAALATVISRGIAAVIGLYLLFKGRVG----LKISLRDLKpDWewlKKIFR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 262 LAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLL 341
Cdd:cd13142 242 IGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAAL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 342 ITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGL 421
Cdd:cd13142 322 LIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRI 401
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 22907060 422 PIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKK 464
Cdd:cd13142 402 PLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWKK 444
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
36-462 |
2.20e-33 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 131.91 E-value: 2.20e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 36 RALLVLAGPAFLVQLMVFLISFISSVFCGHLGKL-ELDAVTLAIAVINVTGVSVGFgLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVALGTTIFNTLFWLFGF-LRMGTTGLVAQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 115 ILQRS-------ALVLLLCCFPcwaLFLntqHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQ 187
Cdd:cd13136 82 LLVRAlllalaiGLLLILLQSP---LLA---LALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 188 IVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSM 267
Cdd:cd13136 156 LILQIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKLNRDIF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 268 LM-----LCMEWWAYevgsfLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLI 342
Cdd:cd13136 236 IRtlallAAFLFFTA-----LAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQW 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 343 TVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGA---IVNTIGYYVV 419
Cdd:cd13136 311 GLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRnsmLVSLAVFLPL 390
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 22907060 420 glpigiALMFATTLGVMGLWSGIIIctvFQAVCFLGFIIQLNW 462
Cdd:cd13136 391 ------LFLLVPLWGNHGLWLALIL---FMLLRGLTLALRLPR 424
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
36-439 |
4.49e-32 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 128.40 E-value: 4.49e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 36 RALLVLAGPAFLVQLMVFLISFISSVFCGHL-GKLELDAVTLAIAVIN-VTGVSVGFGLSSAcdTLISQTYGSQNLKHVG 113
Cdd:cd13143 4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMlLMALGLMIGVGGA--SLISRRLGAGDREKAN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 114 VILQRS-ALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGV 192
Cdd:cd13143 82 RIFSTAlLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGML 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 193 AANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKK-LHQATWGGWSLEcLQDWASFLRLAIPSMLMlc 271
Cdd:cd13143 162 IGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKsLLKLSLLRFKLS-LKIIKEILALGFPSFLM-- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 272 mewwayEVGSFLSGIL---------GMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLI 342
Cdd:cd13143 239 ------QLSSSVVTIVlnltllgygGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 343 TVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVvgLP 422
Cdd:cd13143 313 ALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGL--FL 390
|
410
....*....|....*..
gi 22907060 423 IGIALMFATTLGVMGLW 439
Cdd:cd13143 391 IPLLLILPRLFGLDGIW 407
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
265-424 |
9.95e-26 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 103.41 E-value: 9.95e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 265 PSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITV 344
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 345 LFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGyYVVGLPIG 424
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPLN 159
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
44-204 |
6.97e-25 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 101.10 E-value: 6.97e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 44 PAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVsVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVL 123
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFM-FLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 124 LLCCFP-CWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALAN 202
Cdd:pfam01554 80 LLLSLPiALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 22907060 203 YL 204
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-463 |
6.37e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 101.45 E-value: 6.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 35 LRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAV---------TLAIAVINVTGVSVGfglssacdtlISQTYG 105
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVgtagffvwlAYALALLSKIGAQVK----------VSQSIG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 106 SQNLKHVGVILQRSALVLLLCCFpCWALFL---NTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQG 182
Cdd:cd13140 74 AKDEKEARKYARNALQLNLLLGI-LYGLLLllfAKPLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 183 -IVLPQIVTGVAaNLVNALANYLFLHQL----HLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWA 257
Cdd:cd13140 153 dSKTPFIINAIG-LVLNIILDPLLIFGFgpfpALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 258 SFLRLAIP----SMLMLCMEWWayeVGSFLSGiLGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQAR 333
Cdd:cd13140 232 EILKLGLPvalqSILFALISMI---LARIIAS-FGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIR 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 334 KSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNT 413
Cdd:cd13140 308 KGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISI 387
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 22907060 414 IGyyvVGLPIGIALMFA-TTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWK 463
Cdd:cd13140 388 VF---NGLRIPLALLLSpTGLGLNGIWWAISISSILKGIILTIWFLLYKKK 435
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
32-477 |
2.20e-22 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 100.20 E-value: 2.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 32 REELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLEL-----DAVTLAIAVINVTGVSVGFGlssacdTLISQTYGS 106
Cdd:PRK00187 6 TTELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALaggglGAASYSFVSIFCVGVIAAVG------TLVAIRHGA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 107 QNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLP 186
Cdd:PRK00187 80 GDIEGATRLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 187 QIVTGVAANLVNALANYLFLHQL----HLGVIGsalANLISQYTLALLLFLYILGKKLHQA-----TWGGWSLECLQDWA 257
Cdd:PRK00187 160 VMVISLAGAVANLLLNYALIEGWfglpKLGLMG---IGLVTALVSNGMALALALYIRRHPAyaaypLRKGLSRPSRAALR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 258 SFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSST 337
Cdd:PRK00187 237 ELWRLGLPIGGTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 338 VSLLITVLFAVAFSVLLLSCKDHVGYIFT-----TDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVN 412
Cdd:PRK00187 317 VGIGFGAVVMLLFAGLFWLLPEAIIGLFLdrndpAFAEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIG 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22907060 413 TIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVcflGFIIQLNWKKACQQAQVHANLKV 477
Cdd:PRK00187 397 LACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAAV---ALTLAFEWKTARLLRKARASEAV 458
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-464 |
5.88e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 86.51 E-value: 5.88e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 36 RALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKHVGVI 115
Cdd:cd13139 14 RAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 116 LQRSALVLLLCCFPCWAL-FLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYmlqvkYLLN---QGIVLPQIV-- 189
Cdd:cd13139 93 AVQAILLGVALSLILSILgYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLL-----FLINgifRGAGDAAIAmr 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 190 TGVAANLVNALANYLFLHQL----HLGVIGSALANLISQYTLALLlflyilgkKLHQATWGGWSLECLQ-----DWA--- 257
Cdd:cd13139 168 SLWLANGLNIILDPLFIFGLgpipAMGVTGAAIATTIGRSIGVLY--------QLYHLFKGKGRIQIRRrhlklDWAiik 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 258 SFLRLAIPSML--MLCMEWWAyevgsFLSGILGmvELGAQSIV-YELAIIVYMV---PA-GFSVAASVRVGNALGAGDME 330
Cdd:cd13139 240 KIIKIAVGGILqfLIASSSWI-----FLVRIIA--EFGSTALAgYTIAIRIIMFallPAwGLSNAAATLVGQNLGAGQPD 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 331 QARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAI 410
Cdd:cd13139 313 RAEKSVWRAGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTL 392
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 22907060 411 VNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKK 464
Cdd:cd13139 393 INLVGFWLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKWKT 446
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-439 |
5.31e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 80.35 E-value: 5.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 35 LRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13144 7 LRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEANK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 115 ILQRS-ALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVA 193
Cdd:cd13144 86 AANNGlLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 194 ANLVNALANYLFLHQLH----LGVIGSALANLISQYTLALLLFLYILGKKL-HQATWGGWSLEcLQDWASFLRLAIPSML 268
Cdd:cd13144 166 GAIINIILDPILIFGLFgfpaMGIAGAAIATVIGQILAMFLAFFFLLRKNKdVQPDLRLFRPS-LRIIKEIYAVGLPSII 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 269 MLCMewwayevGSFLSGILGMVELG-------AQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLL 341
Cdd:cd13144 245 MQAI-------SSVMVFGLNKILAGfgptavaVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAIL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 342 ITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGL 421
Cdd:cd13144 318 IAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLL 397
|
410
....*....|....*...
gi 22907060 422 PigIALMFATTLGVMGLW 439
Cdd:cd13144 398 P--LAWLLAKMFGLNGVW 413
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
38-444 |
2.33e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 78.49 E-value: 2.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 38 LLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINvTGVSVGFGLSSACDTLISQTYGSQNLKHvgvILQ 117
Cdd:cd13135 3 INHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFN-TITGFLGSISIGFTILGSQSVGAKDIKR---IND 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 118 RSALVLLLCCFPCWALFL----NTQHILLLFRQDPDVSRLTQTYVTIFIPAL-----PATFLYMLQVkyllnQGIVLPQI 188
Cdd:cd13135 79 YAISSIVYNSIIGVILFLlwlfGARIIFVLFGVDGQILGYSINYVRIFSIYLlllgiLFTFSSILQG-----IGETKPIM 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 189 VTGVAANLVNALANYLF----LHQLHLGVIGSALANLISQYTLAL-LLFLYILGKKLHQATWGGWSLEclQDWASFL--- 260
Cdd:cd13135 154 YGGIIKNLLNVILDYVLifgnFGFPRLGIIGAAIATTIANVLNLIiLVYLCRKIKKLTFKLSNTKVLK--ANIRPYKfti 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 261 RLAIPSMlmlcMEWWAYEVG-----SFLSGIlGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKS 335
Cdd:cd13135 232 KLGLPLG----GEEFLWNIGnlaviRILNRI-GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRI 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 336 STVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQK---VGAIVN 412
Cdd:cd13135 307 GNICLGLGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKwmlYTQIIG 386
|
410 420 430
....*....|....*....|....*....|..
gi 22907060 413 TIgyYVVGLpiGIALMFATTLGVMGLWSGIII 444
Cdd:cd13135 387 TI--IVVSV--ALLLIFVFKLGLAGVYITLFI 414
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-444 |
2.90e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 71.95 E-value: 2.90e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 35 LRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGvSVGFGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13149 8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLN-SLTIGLGIGASAVISRAIGAGDRNKAKR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 115 ILQRSALVLLLCCFPCWALFLNTQHILL-LFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQG-IVLPQIVTGV 192
Cdd:cd13149 87 LATDSLILSLLLSVIVSLLGLFTIPPLFsLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGdTKRPSLVMLG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 193 AAnLVNALANYLFLHQL----HLGVIGSALANLISQyTLALLLFLYILGKKLHQATWGGWSL-ECLQDWASFLRLAIPSM 267
Cdd:cd13149 167 AA-LVNVILDPILIFGFgpipGMGIAGAAIATVISR-ALGLGAALYFLHYHHRLIDFSEPSLkALFRSWKDILSIGIPAA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 268 LMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFA 347
Cdd:cd13149 245 LSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYG 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 348 VAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPigIAL 427
Cdd:cd13149 325 AILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIP--LAY 402
|
410
....*....|....*..
gi 22907060 428 MFATTLGVMGLWSGIII 444
Cdd:cd13149 403 VGSHLLGFAGVFIGALA 419
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
21-223 |
6.78e-12 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 67.48 E-value: 6.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 21 RGSRCLRLSAF-----REELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSA 95
Cdd:COG0534 209 RKRSLLRLRLRdlrpdRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 96 CDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALF-LNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQ 174
Cdd:COG0534 288 AQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLfLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVL 367
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 22907060 175 VKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLIS 223
Cdd:COG0534 368 SGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIG 416
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
46-454 |
2.25e-09 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 59.19 E-value: 2.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 46 FLVQLMVFLISFISSVFCGH-LGKLELDAVTLAIAVINVTGVSVGFGLSSAcdtlISQTYGSQNLKHVGVILQRSALVLL 124
Cdd:COG2244 12 LLGQLLGALLGFLLLPLLARlLGPEEYGLFALALSIVALLSVLADLGLSTA----LVRFIAEYREEELRRLLSTALLLRL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 125 LCCFPCWALFLNTQHILLLFRQDPDVsrltQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYL 204
Cdd:COG2244 88 LLSLLLALLLLLLAPFIAALLGEPEL----ALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLLLALL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 205 FLhqlhlgvigsalanlisqytlalllflyilgkklhqatWGGWSLeclqdWASFLRLAIPSMLMLCMEWWAYEVGSF-L 283
Cdd:COG2244 164 LA--------------------------------------LLGLGL-----WGLVLKYSLPLLLSGLLGLLLTNLDRLlL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 284 SGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGY 363
Cdd:COG2244 201 GALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLS 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 364 IFTTDRDIInlVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGyyvVGLPIGIALMFATTLGVMGLWSGII 443
Cdd:COG2244 281 LLFGPEYAE--AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIG---AVLNLVLNLLLIPRYGLVGAAIATL 355
|
410
....*....|.
gi 22907060 444 ICTVFQAVCFL 454
Cdd:COG2244 356 LSYLVLLLLLL 366
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
87-450 |
2.02e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 56.64 E-value: 2.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 87 SVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWAL-FLNTQHILLLFRQDPDVSRLTQTYVTIFIPAL 165
Cdd:cd13146 61 ALGNGIQVGVSSLLARAIGAQRAKELDQAADSGLALALLAATVIVVLgYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGV 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 166 PATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKK----LH 241
Cdd:cd13146 141 PFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKsnvtIH 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 242 QA-TWGGWSLeclqdWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRV 320
Cdd:cd13146 221 IKlSNISSSV-----IVEILRVGLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIA 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 321 GNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLR 400
Cdd:cd13146 296 GQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQ 375
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 22907060 401 GSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQA 450
Cdd:cd13146 376 AIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSANFFTA 425
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
260-454 |
8.53e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 51.50 E-value: 8.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 260 LRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAG-FSVAASVRVGNALGAGDMEQARKSSTV 338
Cdd:cd13148 15 LRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTQMMSNGaMGGGVSSAIARALGAGDRERAEALVWH 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 339 SLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVnTIGYYV 418
Cdd:cd13148 95 ALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALV-TLVGAV 173
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 22907060 419 VGLPIGIALMF----ATTLGVMGLWSGIIICTVFQAVCFL 454
Cdd:cd13148 174 VQIPLSPGLILgwgpLPRLGVAGAAVAAVLYYALAALVLL 213
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
260-464 |
1.84e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 50.60 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 260 LRLAIPSMLMLCME--------WWAYEVGSflsgilgmvelGAQSIVYELAIIVYMVPAGFSVA---ASVRVGNALGAGD 328
Cdd:cd13140 8 LRLALPIMGTSFIQmaynltdmFWVGRLGS-----------DAVAAVGTAGFFVWLAYALALLSkigAQVKVSQSIGAKD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 329 MEQARKSSTVSLLITVLFAVAFSVLLLSCKDhvGYIfttdrDIINLVAQVVPIYAVSHLFeALACTS---------GGVL 399
Cdd:cd13140 77 EKEARKYARNALQLNLLLGILYGLLLLLFAK--PLI-----GFFNLGDAEVISLAITYLR-IVALGLifsflnpvfTGIF 148
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22907060 400 RGSGNQKVGAIVNTIGyyvVGL-----PIgiaLMF----ATTLGVMglwsGIIICTVF-QAVCFLGFIIQLNWKK 464
Cdd:cd13140 149 NALGDSKTPFIINAIG---LVLniildPL---LIFgfgpFPALGVA----GAALATVLaQAIVFLLFLYALKKKK 213
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
38-451 |
3.44e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 49.62 E-value: 3.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 38 LLVLAGP---AFLVQLMVFLISFIssvFCGHLGKLELDAVTLA----IAVINVTGVsvgfgLSSACDTLISQTYGSQNLK 110
Cdd:cd13141 13 IISMALPiaiGMIIQTLYFLVDLY---FVGQLGDAALAGVSLAgnvmFFVMALTQV-----LNVGTAALVSHAVGRKDQG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 111 HVGVILQRSALVLLLCCFPCWAL-FLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIV 189
Cdd:cd13141 85 EANAVFNQSLLLAAVLGLVVLVLgYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 190 TGVAANLVNALANYLFLHQL----HLGVIGSALANLISQYTLALLLFL-YILGKKLHQATWGGWSLEcLQDWASFLRLAI 264
Cdd:cd13141 165 IQILAVLLNIILAPILITGWgtgrALGVAGAGLASSISVAIAVVLLLYyFLRLEKYLRLDLALWRPD-LPTWKRLLKIGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 265 PS----MLMLC---MEWWAY-EVGS-----FLSG--ILGMVELGAQSIVYELAIIvymvpagfsvaasvrVGNALGAGDM 329
Cdd:cd13141 244 PSggefLLTFVymaVIYWALrPFGAaaqagFGIGsrIMQSLFLPAMAIAFAAPAI---------------AGQNFGAGNY 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 330 EQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGA 409
Cdd:cd13141 309 DRVRETFRITAILTTALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSL 388
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 22907060 410 IVNTIGYYVVGLPIgIALMFATTLGVMGLWSGIIICTVFQAV 451
Cdd:cd13141 389 LSSASRLLTFALPV-IWLSAQPDFRIEQIWYLSVATTILQAA 429
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
26-173 |
6.00e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 48.66 E-value: 6.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 26 LRLSAFREELRALLVLAGPAFLVQLMvflISFISSVFCGHLGKLELDAVTLAIAVIN-VTGVS--VGFGLSSACDTLISQ 102
Cdd:cd13143 216 LRFKLSLKIIKEILALGFPSFLMQLS---SSVVTIVLNLTLLGYGGDIGVAAFGIVTrILTFLflPLIGLSQGLQPIIGY 292
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22907060 103 TYGSQNLKHVGVILQRSALVLLLCCFPCWA-LFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYML 173
Cdd:cd13143 293 NYGAGNYDRVKQALKLALIVALIYGLVLFLiLLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIV 364
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
86-454 |
6.26e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 48.75 E-value: 6.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 86 VSVGFGLSSACDTLISQTYGSQNLKHV-GVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYV-TIFIp 163
Cdd:cd13145 58 IAIGVGIGTGTTALIGNALGAGDRRKArRYAAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMdVIFA- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 164 alpATFLYMLQvkYLLNqGIVLPQIVTGVAAN------LVNALANYLFLH----QLHLGVIGSALANLISQYTLALLLFL 233
Cdd:cd13145 137 ---GSIFFLLN--FGLN-GILNAQGDTKSYRNfliigfFLNIILDPLFIFggggIPAMGVSGIALATIISQFIGMFYLLY 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 234 YILGKKLHQATWGGWSLECLQDWASFLRLAIPSML-MLCMEWWAYEVGSFLSGiLGMVELGAQSIVYELAIIVYMVPAGF 312
Cdd:cd13145 211 KVRKSGIISGCRLRDFIPRLDVYKEILKQGFPASLnMMTIGLGIFVITYFVGQ-FGDEAVAAYGIALRIEQILLLPTIGL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 313 SVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQ-------VVPIYAVs 385
Cdd:cd13145 290 NTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGylridalIFYAYVV- 368
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22907060 386 hLFealacTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFL 454
Cdd:cd13145 369 -LF-----ISVSVLQGLKRPIFALWIGLYRQLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIAL 431
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
58-447 |
2.64e-05 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 46.91 E-value: 2.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 58 ISSVFCGH-LGKLELDAVTLAIAVInvtGVSVGFGLSSACDT--LISQTYGSQNLKHVGVILQrSALVLLLCCFPCWA-- 132
Cdd:PRK09575 34 VDGIFIGHyVGAEGLAGINMAWPVI---GIILGIGLMVGMGTgsLLSIKRGEGDLEKAKRILT-TGLLLLLLLGPIVSvi 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 133 LFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIvlPQIVTG--VAANLVNALANYLFLHQLH 210
Cdd:PRK09575 110 LFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDES--PNLATGlmVIGALINIVLDYLFIGWLD 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 211 LGVIGSALANLISQYTlallLFLYILGKKLHQATWGGWSLECLQ-DWASFLRLAIPSMLMLCMewwaYEVGSF---LSGI 286
Cdd:PRK09575 188 WGLTGAAIATALAQLV----VTVLGLGYFFSSRANIRLTLKELRfNWSLAPKIVLLGSSSFFM----YLYGSFvvaLHNR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 287 LGM-----VELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLL-LSCKDH 360
Cdd:PRK09575 260 LFMeygsaLTVGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTVLAGIAWVLLLnLFPETM 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 361 VGYIFTTDRDIINlvAQVVPIYAvsHLFeALACTSGGVLRG----SGNQKVGAIVNTIGYYVVGLPIgiaLMF-ATTLGV 435
Cdd:PRK09575 340 IALFNSGDSELIA--ETIVGIRL--HLF-AMFLDGFLVLASayfmAVNQGGKALFISIGNMLIQLPF---LFIlPKWLGV 411
|
410
....*....|....*..
gi 22907060 436 MGLW-----SGIIICTV 447
Cdd:PRK09575 412 DGVWlamplSNIALSLV 428
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
36-458 |
3.78e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 46.38 E-value: 3.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 36 RALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKHVGVI 115
Cdd:cd13147 9 KAIIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMII-IGLGNGLGAGASSAISRRIGAKDKEGADNA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 116 LQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAAN 195
Cdd:cd13147 88 AVHSILLGLIISIILTIVLLPFLEPILVLMGAGEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 196 LVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKK-------LHQATwggWSLECLQDwasFLRLAIPSML 268
Cdd:cd13147 168 ILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVKKdtyvslsLKNFK---FDKKIVKD---ILKVGIPASL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 269 -MLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFA 347
Cdd:cd13147 242 eQLIMSVLMIILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIE 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 348 VAFSVLLLSCKDHVGYIFTTDRDIINLVAQVV---PIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIgyYVVGLPIG 424
Cdd:cd13147 322 LIIAILIFIFAPQIAYLFTYSEESAHLAPEIVaflRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITIL--RELIFQVL 399
|
410 420 430
....*....|....*....|....*....|....*.
gi 22907060 425 IALMFATTL--GVMGLWSGIIICTVfqAVCFLGFII 458
Cdd:cd13147 400 FAYLFAIVLglGLFGVWWGIVLGNA--IGSIVGYLW 433
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
32-226 |
5.59e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 45.58 E-value: 5.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 32 REELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKH 111
Cdd:cd13137 222 RKIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLA-FMPGFGFSMAASTLVGQNLGAGDPDE 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 112 VGVILQRSAL--VLLLCCFpCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIV 189
Cdd:cd13137 301 ARRYGKRALRlgVLFMGLL-GLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLI 379
|
170 180 190
....*....|....*....|....*....|....*...
gi 22907060 190 TGVAANLVNALA-NYLFLHQLHLGVIGSALANLISQYT 226
Cdd:cd13137 380 INLISMWLVRLPlAYLLGFVLGLGLTGIWLAMFVDTIV 417
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
26-308 |
9.04e-04 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 42.06 E-value: 9.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 26 LRLSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGkleldavTLAIAVIN--------VTGVsVGFGLSSACD 97
Cdd:COG0728 212 PRFDLRDPGVRRVLKLMLPALLGVSVSQINLLVDTILASFLP-------EGSVSALYyadrlyqlPLGL-FGVAIGTALL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 98 TLISQTYGSQNLKHVGVILQRSALVLLLCCFPC--WALFLNTQHILLLF---RQDPDVSRLTQTYVTIFIPALPATFLYM 172
Cdd:COG0728 284 PRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAavGLIVLAEPIVRLLFergAFTAEDTALTALALAAYALGLPAFALVK 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 173 LQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHqlHLGVIGSALANLISqYTLALLLFLYILGKKLHQATWGGWslec 252
Cdd:COG0728 364 VLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVP--PLGHAGLALATSLS-ALVNALLLLVLLRRRLGGLPLRGI---- 436
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 22907060 253 lqdWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMV 308
Cdd:COG0728 437 ---LRTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFA 489
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
279-354 |
8.79e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 38.73 E-value: 8.79e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22907060 279 VGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKsstvSLLITVLFAVAFSVLL 354
Cdd:cd13145 31 VDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARR----YAAQGLSFGIILAILL 102
|
|
|