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Conserved domains on  [gi|22907060|ref|NP_060712|]
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multidrug and toxin extrusion protein 1 [Homo sapiens]

Protein Classification

MATE family efflux transporter( domain architecture ID 10192067)

MATE (multidrug and toxic compound extrusion) family efflux transporter functions in protecting cells against oxidative stress and bile salts and may be part of the SOS system; similar to Arabidopsis thaliana MATE proteins which confer aluminum tolerance

Gene Ontology:  GO:0016020|GO:0015297|GO:0022857
PubMed:  26246409|33774036|31866287
TCDB:  2.A.66

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 34-468 0e+00

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


:

Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 526.76  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  34 ELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVG 113
Cdd:cd13132   1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 114 VILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVA 193
Cdd:cd13132  81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 194 ANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCME 273
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 274 WWAYEVGSFLSGIL-GMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSV 352
Cdd:cd13132 241 WWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAI 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 353 LLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATT 432
Cdd:cd13132 321 LLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVLG 400

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 22907060 433 LGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQ 468
Cdd:cd13132 401 LGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 34-468 0e+00

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 526.76  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  34 ELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVG 113
Cdd:cd13132   1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 114 VILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVA 193
Cdd:cd13132  81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 194 ANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCME 273
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 274 WWAYEVGSFLSGIL-GMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSV 352
Cdd:cd13132 241 WWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAI 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 353 LLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATT 432
Cdd:cd13132 321 LLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVLG 400

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 22907060 433 LGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQ 468
Cdd:cd13132 401 LGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
35-456 1.50e-70

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 233.11  E-value: 1.50e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  35 LRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:COG0534   7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARR 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 115 ILQRSALVLLLCCFPCWAL-FLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVA 193
Cdd:COG0534  86 VLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 194 ANLVNALANYLFLHQLHLGVIGSALANLISQY-TLALLLFLYILGKKLHQATWGGWSLEcLQDWASFLRLAIPSMLMLCM 272
Cdd:COG0534 166 GNVLNIVLDPLLIFGGGLGVAGAALATVISQAvSALLLLYYLFRKRSLLRLRLRDLRPD-RKILKRILRIGLPAGLQQLA 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 273 EWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSV 352
Cdd:COG0534 245 ESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLAL 324

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 353 LLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFaTT 432
Cdd:COG0534 325 LLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LG 403

                       410       420
                ....*....|....*....|....
gi 22907060 433 LGVMGLWSGIIICTVFQAVCFLGF 456
Cdd:COG0534 404 LGLTGVWLALPIGEVLRALLLLLR 427
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 44-383 1.18e-60

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 204.40  E-value: 1.18e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060    44 PAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAiAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVL 123
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   124 LLCCFPCWALFLNTQHILLLFRQ-DPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALAN 202
Cdd:TIGR00797  80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   203 YLFLHQLH--LGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVG 280
Cdd:TIGR00797 160 YILIFGKFgfLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   281 SFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDH 360
Cdd:TIGR00797 240 ALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREF 319

                         330       340
                  ....*....|....*....|...
gi 22907060   361 VGYIFTTDRDIINLVAQVVPIYA 383
Cdd:TIGR00797 320 IARLFTNDPEVLELAAIYLIFVA 342
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 29-444 2.32e-41

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 155.36  E-value: 2.32e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   29 SAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAiAVINVTGVSVGFGLSSACDTLISQTYGSQN 108
Cdd:PRK01766   5 QKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIG-TSIWLPVILFGHGLLLALTPIVAQLNGAGR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  109 LKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQ-DPDVSRLTQTYVTIFIPALPATFLYmlQVKYLLNQGIVLPQ 187
Cdd:PRK01766  84 RERIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNlEPEVADIAVGYLHALLWGIPAYLLY--QVLRSFIDGLGKTK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  188 I--VTGVAANLVNALANYLFLHQL----HLGVIGSALANLISqYTLALLLFLYILGKKLHQAT---WGGWSLECLQDWAS 258
Cdd:PRK01766 162 PtmVIGFLGLLINIPLNYIFIYGKfgfpELGGVGCGVATAIV-YWVMFLAMLIYIKRARRFRDfrlFKGLYKPDWAVIKR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  259 FLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTV 338
Cdd:PRK01766 241 LLKLGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  339 SLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYV 418
Cdd:PRK01766 321 GLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWV 400

                        410       420
                 ....*....|....*....|....*.
gi 22907060  419 VGLPIGIALMFATTLGVMGLWSGIII 444
Cdd:PRK01766 401 LGLPLGYILALTDPMGPFGFWIGLII 426
MatE pfam01554
MatE; The MatE domain
 265-424 9.95e-26

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 103.41  E-value: 9.95e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   265 PSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITV 344
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   345 LFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGyYVVGLPIG 424
Cdd:pfam01554  81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPLN 159
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 34-468 0e+00

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 526.76  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  34 ELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVG 113
Cdd:cd13132   1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 114 VILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVA 193
Cdd:cd13132  81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 194 ANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCME 273
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 274 WWAYEVGSFLSGIL-GMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSV 352
Cdd:cd13132 241 WWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAI 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 353 LLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATT 432
Cdd:cd13132 321 LLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVLG 400

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 22907060 433 LGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQ 468
Cdd:cd13132 401 LGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
35-456 1.50e-70

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 233.11  E-value: 1.50e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  35 LRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:COG0534   7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARR 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 115 ILQRSALVLLLCCFPCWAL-FLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVA 193
Cdd:COG0534  86 VLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 194 ANLVNALANYLFLHQLHLGVIGSALANLISQY-TLALLLFLYILGKKLHQATWGGWSLEcLQDWASFLRLAIPSMLMLCM 272
Cdd:COG0534 166 GNVLNIVLDPLLIFGGGLGVAGAALATVISQAvSALLLLYYLFRKRSLLRLRLRDLRPD-RKILKRILRIGLPAGLQQLA 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 273 EWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSV 352
Cdd:COG0534 245 ESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLAL 324

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 353 LLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFaTT 432
Cdd:COG0534 325 LLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LG 403

                       410       420
                ....*....|....*....|....
gi 22907060 433 LGVMGLWSGIIICTVFQAVCFLGF 456
Cdd:COG0534 404 LGLTGVWLALPIGEVLRALLLLLR 427
MATE_NorM_like cd13131
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ...
 34-463 1.51e-70

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.


Pssm-ID: 240536 [Multi-domain]  Cd Length: 435  Bit Score: 233.16  E-value: 1.51e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  34 ELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKHVG 113
Cdd:cd13131   1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 114 VILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVA 193
Cdd:cd13131  80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 194 ANLVNALANYLFLHQL----HLGVIGSALANLISQY-TLALLLFLYILGKKLHQ-ATWGGWSLECLQDWASFLRLAIPSM 267
Cdd:cd13131 160 ALVLNIPLNYVLIFGKfglpALGGAGAGLATAIVYWlMFLALAFYIRRHKRFRRyRLFARFWRPDWARLKELLRLGLPIG 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 268 LMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFA 347
Cdd:cd13131 240 LTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFA 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 348 VAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIAL 427
Cdd:cd13131 320 ALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLGYLL 399

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 22907060 428 MFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWK 463
Cdd:cd13131 400 AFTTGLGAFGVWIGLIIGLALAAILLLWRFRRLQRR 435
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 44-383 1.18e-60

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 204.40  E-value: 1.18e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060    44 PAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAiAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVL 123
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   124 LLCCFPCWALFLNTQHILLLFRQ-DPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALAN 202
Cdd:TIGR00797  80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   203 YLFLHQLH--LGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVG 280
Cdd:TIGR00797 160 YILIFGKFgfLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   281 SFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDH 360
Cdd:TIGR00797 240 ALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREF 319

                         330       340
                  ....*....|....*....|...
gi 22907060   361 VGYIFTTDRDIINLVAQVVPIYA 383
Cdd:TIGR00797 320 IARLFTNDPEVLELAAIYLIFVA 342
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 42-458 6.75e-55

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 191.38  E-value: 6.75e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  42 AGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINvTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSAL 121
Cdd:cd12082   1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIA-LLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 122 VLLLCCFPCWALFL-NTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNAL 200
Cdd:cd12082  80 LAILLGLLLAALLLfFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 201 ANYLFLHQL---HLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAY 277
Cdd:cd12082 160 LDPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 278 EVGSFL-SGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLS 356
Cdd:cd12082 240 LIIVAIvAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILL 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 357 CKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFAtTLGVM 436
Cdd:cd12082 320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYL-GLGLY 398

                       410       420
                ....*....|....*....|..
gi 22907060 437 GLWSGIIICTVFQAVCFLGFII 458
Cdd:cd12082 399 GIWLALVISLILAALVLLLFFR 420
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 36-463 1.62e-51

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 182.33  E-value: 1.62e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  36 RALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVsVGFGLSSACDTLISQTYGSQNLKHVGVI 115
Cdd:cd13137   1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLV-LNMALGTGTVALVSQSYGAGDYERARRA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 116 LQRSALVLLLCCFP-CWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAA 194
Cdd:cd13137  80 LGQSLLLALLLSLPlALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 195 NLVNALANYLF----LHQLHLGVIGSALANLISQYTLALLLFLYILGKKLH-QATWGGWSLEcLQDWASFLRLAIPSMLM 269
Cdd:cd13137 160 NVLNIVLDYVLifglWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPiKISFKGFRLD-RKIIKKLLRIGLPAGLE 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 270 LCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVA 349
Cdd:cd13137 239 QLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGL 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 350 FSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMF 429
Cdd:cd13137 319 LGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGF 398

                       410       420       430
                ....*....|....*....|....*....|....
gi 22907060 430 ATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWK 463
Cdd:cd13137 399 VLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 35-462 8.69e-46

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 166.93  E-value: 8.69e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  35 LRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAiAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13133   4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGR 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 115 ILQRSALVLLLCCFPCWAL-FLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLY-MLQVKYLlnqGIVLPQIVTG- 191
Cdd:cd13133  83 VLWQGLYFSLLLAPLLALLsALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGaALRAFFS---GIGRTRVVMVa 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 192 -VAANLVNALANYLF----LHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQ--ATWGGWSLEcLQDWASFLRLAI 264
Cdd:cd13133 160 nLVMVVVNIVLDYALifgkLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRrfGLRRAWRFD-RELLRRILRLGL 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 265 PSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITV 344
Cdd:cd13133 239 PSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLAL 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 345 LFAVAFSVLLLSCKDHVGYIFTTDRD---IINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGL 421
Cdd:cd13133 319 AYMLLLGILFLLFPELLLSIFTPGADfalIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLL 398

                       410       420       430       440
                ....*....|....*....|....*....|....*....|.
gi 22907060 422 PIGIALMFAtTLGVMGLWSGIIICTVFQAVCFLGFIIQLNW 462
Cdd:cd13133 399 PPAYLLVVL-GAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 29-444 2.32e-41

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 155.36  E-value: 2.32e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   29 SAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAiAVINVTGVSVGFGLSSACDTLISQTYGSQN 108
Cdd:PRK01766   5 QKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIG-TSIWLPVILFGHGLLLALTPIVAQLNGAGR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  109 LKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQ-DPDVSRLTQTYVTIFIPALPATFLYmlQVKYLLNQGIVLPQ 187
Cdd:PRK01766  84 RERIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNlEPEVADIAVGYLHALLWGIPAYLLY--QVLRSFIDGLGKTK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  188 I--VTGVAANLVNALANYLFLHQL----HLGVIGSALANLISqYTLALLLFLYILGKKLHQAT---WGGWSLECLQDWAS 258
Cdd:PRK01766 162 PtmVIGFLGLLINIPLNYIFIYGKfgfpELGGVGCGVATAIV-YWVMFLAMLIYIKRARRFRDfrlFKGLYKPDWAVIKR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  259 FLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTV 338
Cdd:PRK01766 241 LLKLGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  339 SLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYV 418
Cdd:PRK01766 321 GLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWV 400

                        410       420
                 ....*....|....*....|....*.
gi 22907060  419 VGLPIGIALMFATTLGVMGLWSGIII 444
Cdd:PRK01766 401 LGLPLGYILALTDPMGPFGFWIGLII 426
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 36-464 1.07e-40

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 153.04  E-value: 1.07e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  36 RALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVsVGFGLSSACDTLISQTYGSQNLKHVGVI 115
Cdd:cd13134   3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLIL-IFSFISTGTSILIAQYLGAKDKKKARQI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 116 LQRS-ALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAA 194
Cdd:cd13134  82 AGVAlLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIM 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 195 NLVNALANYLFLHQLH----LGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLml 270
Cdd:cd13134 162 NILNIVGNYLLIFGWFglpkLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLPSAG-- 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 271 cmEWWAYEVGSFLS----GILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLF 346
Cdd:cd13134 240 --EELSYNLSQTVItafiARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLV 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 347 AVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIA 426
Cdd:cd13134 318 SLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYL 397

                       410       420       430
                ....*....|....*....|....*....|....*...
gi 22907060 427 LMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKK 464
Cdd:cd13134 398 LGIVLGLGLLGVWIAFAADEWVRGIIMLWRWRSGKWIK 435
MATE_yoeA_like cd13138
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 35-463 2.00e-35

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240543 [Multi-domain]  Cd Length: 431  Bit Score: 137.98  E-value: 2.00e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  35 LRALLVLAGPAFLVQLMVFLISFISSVFCGH-LGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKHVG 113
Cdd:cd13138   2 LKTLLLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLL-TAIGMGLSMGGTILISQYIGAKDEEKAK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 114 -------VILQRSALVLLLCCFPCwalflnTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYmlqvkYLLN---QGI 183
Cdd:cd13138  81 kavgtllVLFLILGIVLTILGLLF------APPILRLMNTPAEILELAVSYLRICFLGIPFIFGY-----NAYSailRGL 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 184 ---VLPQIVTGVAAnLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHqatwGGWSLECLQ-DWASF 259
Cdd:cd13138 150 gdsKTPLYFVIIAC-VLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLP----FKLSLKDFRfDKEIL 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 260 ---LRLAIPSMLMLCMewwayevgSFLSGIL--------GMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGD 328
Cdd:cd13138 225 keiLKIGLPSALQQSL--------VSISFLIinsivnsyGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGK 296

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 329 MEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVG 408
Cdd:cd13138 297 IERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFP 376

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22907060 409 AIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWK 463
Cdd:cd13138 377 MIISILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
MATE_like_12 cd13142
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 35-464 6.20e-35

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240547 [Multi-domain]  Cd Length: 444  Bit Score: 136.94  E-value: 6.20e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  35 LRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVInVTGVSVGFGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13142  10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLI-FLFISLGGGLTVAGTALVAQYTGAGDYDKANK 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 115 ILQRSALVLLLCCFPCWAL--FLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMlqVKYLLNQGI---VLPQIV 189
Cdd:cd13142  89 VAGQTFSFVIILSLILAVLgyILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFF--VFNSLLRGIgdtKTPMKI 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 190 TGVAAnLVNALANYLFLHQL----HLGVIGSALANLISQYTLALLLFLYILGKKLHqatwGGWSLECLQ-DW---ASFLR 261
Cdd:cd13142 167 MFGSV-LLNVILDPLLIFGIgpfpGLGVAGAALATVISRGIAAVIGLYLLFKGRVG----LKISLRDLKpDWewlKKIFR 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 262 LAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLL 341
Cdd:cd13142 242 IGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAAL 321

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 342 ITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGL 421
Cdd:cd13142 322 LIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRI 401

                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 22907060 422 PIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKK 464
Cdd:cd13142 402 PLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWKK 444
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
 36-462 2.20e-33

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 131.91  E-value: 2.20e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  36 RALLVLAGPAFLVQLMVFLISFISSVFCGHLGKL-ELDAVTLAIAVINVTGVSVGFgLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13136   3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVALGTTIFNTLFWLFGF-LRMGTTGLVAQALGAGDREEAIA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 115 ILQRS-------ALVLLLCCFPcwaLFLntqHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQ 187
Cdd:cd13136  82 LLVRAlllalaiGLLLILLQSP---LLA---LALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTP 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 188 IVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSM 267
Cdd:cd13136 156 LILQIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKLNRDIF 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 268 LM-----LCMEWWAYevgsfLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLI 342
Cdd:cd13136 236 IRtlallAAFLFFTA-----LAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQW 310

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 343 TVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGA---IVNTIGYYVV 419
Cdd:cd13136 311 GLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRnsmLVSLAVFLPL 390

                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 22907060 420 glpigiALMFATTLGVMGLWSGIIIctvFQAVCFLGFIIQLNW 462
Cdd:cd13136 391 ------LFLLVPLWGNHGLWLALIL---FMLLRGLTLALRLPR 424
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 36-439 4.49e-32

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 128.40  E-value: 4.49e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  36 RALLVLAGPAFLVQLMVFLISFISSVFCGHL-GKLELDAVTLAIAVIN-VTGVSVGFGLSSAcdTLISQTYGSQNLKHVG 113
Cdd:cd13143   4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMlLMALGLMIGVGGA--SLISRRLGAGDREKAN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 114 VILQRS-ALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGV 192
Cdd:cd13143  82 RIFSTAlLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGML 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 193 AANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKK-LHQATWGGWSLEcLQDWASFLRLAIPSMLMlc 271
Cdd:cd13143 162 IGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKsLLKLSLLRFKLS-LKIIKEILALGFPSFLM-- 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 272 mewwayEVGSFLSGIL---------GMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLI 342
Cdd:cd13143 239 ------QLSSSVVTIVlnltllgygGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIV 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 343 TVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVvgLP 422
Cdd:cd13143 313 ALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGL--FL 390

                       410
                ....*....|....*..
gi 22907060 423 IGIALMFATTLGVMGLW 439
Cdd:cd13143 391 IPLLLILPRLFGLDGIW 407
MatE pfam01554
MatE; The MatE domain
 265-424 9.95e-26

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 103.41  E-value: 9.95e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   265 PSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITV 344
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   345 LFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGyYVVGLPIG 424
Cdd:pfam01554  81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPLN 159
MatE pfam01554
MatE; The MatE domain
 44-204 6.97e-25

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 101.10  E-value: 6.97e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060    44 PAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVsVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVL 123
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFM-FLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   124 LLCCFP-CWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALAN 202
Cdd:pfam01554  80 LLLSLPiALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159


                  ..
gi 22907060   203 YL 204
Cdd:pfam01554 160 YL 161
MATE_like_1 cd13140
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 35-463 6.37e-23

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240545 [Multi-domain]  Cd Length: 435  Bit Score: 101.45  E-value: 6.37e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  35 LRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAV---------TLAIAVINVTGVSVGfglssacdtlISQTYG 105
Cdd:cd13140   4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVgtagffvwlAYALALLSKIGAQVK----------VSQSIG 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 106 SQNLKHVGVILQRSALVLLLCCFpCWALFL---NTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQG 182
Cdd:cd13140  74 AKDEKEARKYARNALQLNLLLGI-LYGLLLllfAKPLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALG 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 183 -IVLPQIVTGVAaNLVNALANYLFLHQL----HLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWA 257
Cdd:cd13140 153 dSKTPFIINAIG-LVLNIILDPLLIFGFgpfpALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIK 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 258 SFLRLAIP----SMLMLCMEWWayeVGSFLSGiLGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQAR 333
Cdd:cd13140 232 EILKLGLPvalqSILFALISMI---LARIIAS-FGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIR 307

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 334 KSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNT 413
Cdd:cd13140 308 KGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISI 387

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 22907060 414 IGyyvVGLPIGIALMFA-TTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWK 463
Cdd:cd13140 388 VF---NGLRIPLALLLSpTGLGLNGIWWAISISSILKGIILTIWFLLYKKK 435
PRK00187 PRK00187
NorM family multidrug efflux MATE transporter;
32-477 2.20e-22

NorM family multidrug efflux MATE transporter;


Pssm-ID: 166843 [Multi-domain]  Cd Length: 464  Bit Score: 100.20  E-value: 2.20e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   32 REELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLEL-----DAVTLAIAVINVTGVSVGFGlssacdTLISQTYGS 106
Cdd:PRK00187   6 TTELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALaggglGAASYSFVSIFCVGVIAAVG------TLVAIRHGA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  107 QNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLP 186
Cdd:PRK00187  80 GDIEGATRLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  187 QIVTGVAANLVNALANYLFLHQL----HLGVIGsalANLISQYTLALLLFLYILGKKLHQA-----TWGGWSLECLQDWA 257
Cdd:PRK00187 160 VMVISLAGAVANLLLNYALIEGWfglpKLGLMG---IGLVTALVSNGMALALALYIRRHPAyaaypLRKGLSRPSRAALR 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  258 SFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSST 337
Cdd:PRK00187 237 ELWRLGLPIGGTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGR 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  338 VSLLITVLFAVAFSVLLLSCKDHVGYIFT-----TDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVN 412
Cdd:PRK00187 317 VGIGFGAVVMLLFAGLFWLLPEAIIGLFLdrndpAFAEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIG 396

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22907060  413 TIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVcflGFIIQLNWKKACQQAQVHANLKV 477
Cdd:PRK00187 397 LACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAAV---ALTLAFEWKTARLLRKARASEAV 458
MATE_like_14 cd13139
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 36-464 5.88e-18

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240544 [Multi-domain]  Cd Length: 448  Bit Score: 86.51  E-value: 5.88e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  36 RALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKHVGVI 115
Cdd:cd13139  14 RAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 116 LQRSALVLLLCCFPCWAL-FLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYmlqvkYLLN---QGIVLPQIV-- 189
Cdd:cd13139  93 AVQAILLGVALSLILSILgYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLL-----FLINgifRGAGDAAIAmr 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 190 TGVAANLVNALANYLFLHQL----HLGVIGSALANLISQYTLALLlflyilgkKLHQATWGGWSLECLQ-----DWA--- 257
Cdd:cd13139 168 SLWLANGLNIILDPLFIFGLgpipAMGVTGAAIATTIGRSIGVLY--------QLYHLFKGKGRIQIRRrhlklDWAiik 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 258 SFLRLAIPSML--MLCMEWWAyevgsFLSGILGmvELGAQSIV-YELAIIVYMV---PA-GFSVAASVRVGNALGAGDME 330
Cdd:cd13139 240 KIIKIAVGGILqfLIASSSWI-----FLVRIIA--EFGSTALAgYTIAIRIIMFallPAwGLSNAAATLVGQNLGAGQPD 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 331 QARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAI 410
Cdd:cd13139 313 RAEKSVWRAGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTL 392

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 22907060 411 VNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKK 464
Cdd:cd13139 393 INLVGFWLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKWKT 446
MATE_like_4 cd13144
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 35-439 5.31e-16

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240549 [Multi-domain]  Cd Length: 434  Bit Score: 80.35  E-value: 5.31e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  35 LRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13144   7 LRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEANK 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 115 ILQRS-ALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVA 193
Cdd:cd13144  86 AANNGlLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLI 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 194 ANLVNALANYLFLHQLH----LGVIGSALANLISQYTLALLLFLYILGKKL-HQATWGGWSLEcLQDWASFLRLAIPSML 268
Cdd:cd13144 166 GAIINIILDPILIFGLFgfpaMGIAGAAIATVIGQILAMFLAFFFLLRKNKdVQPDLRLFRPS-LRIIKEIYAVGLPSII 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 269 MLCMewwayevGSFLSGILGMVELG-------AQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLL 341
Cdd:cd13144 245 MQAI-------SSVMVFGLNKILAGfgptavaVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAIL 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 342 ITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGL 421
Cdd:cd13144 318 IAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLL 397

                       410
                ....*....|....*...
gi 22907060 422 PigIALMFATTLGVMGLW 439
Cdd:cd13144 398 P--LAWLLAKMFGLNGVW 413
MATE_like_9 cd13135
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 38-444 2.33e-15

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240540 [Multi-domain]  Cd Length: 429  Bit Score: 78.49  E-value: 2.33e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  38 LLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINvTGVSVGFGLSSACDTLISQTYGSQNLKHvgvILQ 117
Cdd:cd13135   3 INHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFN-TITGFLGSISIGFTILGSQSVGAKDIKR---IND 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 118 RSALVLLLCCFPCWALFL----NTQHILLLFRQDPDVSRLTQTYVTIFIPAL-----PATFLYMLQVkyllnQGIVLPQI 188
Cdd:cd13135  79 YAISSIVYNSIIGVILFLlwlfGARIIFVLFGVDGQILGYSINYVRIFSIYLlllgiLFTFSSILQG-----IGETKPIM 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 189 VTGVAANLVNALANYLF----LHQLHLGVIGSALANLISQYTLAL-LLFLYILGKKLHQATWGGWSLEclQDWASFL--- 260
Cdd:cd13135 154 YGGIIKNLLNVILDYVLifgnFGFPRLGIIGAAIATTIANVLNLIiLVYLCRKIKKLTFKLSNTKVLK--ANIRPYKfti 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 261 RLAIPSMlmlcMEWWAYEVG-----SFLSGIlGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKS 335
Cdd:cd13135 232 KLGLPLG----GEEFLWNIGnlaviRILNRI-GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRI 306

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 336 STVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQK---VGAIVN 412
Cdd:cd13135 307 GNICLGLGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKwmlYTQIIG 386

                       410       420       430
                ....*....|....*....|....*....|..
gi 22907060 413 TIgyYVVGLpiGIALMFATTLGVMGLWSGIII 444
Cdd:cd13135 387 TI--IVVSV--ALLLIFVFKLGLAGVYITLFI 414
MATE_like_2 cd13149
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 35-444 2.90e-13

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240554 [Multi-domain]  Cd Length: 434  Bit Score: 71.95  E-value: 2.90e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  35 LRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGvSVGFGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13149   8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLN-SLTIGLGIGASAVISRAIGAGDRNKAKR 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 115 ILQRSALVLLLCCFPCWALFLNTQHILL-LFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQG-IVLPQIVTGV 192
Cdd:cd13149  87 LATDSLILSLLLSVIVSLLGLFTIPPLFsLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGdTKRPSLVMLG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 193 AAnLVNALANYLFLHQL----HLGVIGSALANLISQyTLALLLFLYILGKKLHQATWGGWSL-ECLQDWASFLRLAIPSM 267
Cdd:cd13149 167 AA-LVNVILDPILIFGFgpipGMGIAGAAIATVISR-ALGLGAALYFLHYHHRLIDFSEPSLkALFRSWKDILSIGIPAA 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 268 LMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFA 347
Cdd:cd13149 245 LSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYG 324

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 348 VAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPigIAL 427
Cdd:cd13149 325 AILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIP--LAY 402

                       410
                ....*....|....*..
gi 22907060 428 MFATTLGVMGLWSGIII 444
Cdd:cd13149 403 VGSHLLGFAGVFIGALA 419
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
21-223 6.78e-12

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 67.48  E-value: 6.78e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  21 RGSRCLRLSAF-----REELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSA 95
Cdd:COG0534 209 RKRSLLRLRLRdlrpdRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQA 287

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  96 CDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALF-LNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQ 174
Cdd:COG0534 288 AQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLfLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVL 367

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 22907060 175 VKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLIS 223
Cdd:COG0534 368 SGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIG 416
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
 46-454 2.25e-09

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 59.19  E-value: 2.25e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  46 FLVQLMVFLISFISSVFCGH-LGKLELDAVTLAIAVINVTGVSVGFGLSSAcdtlISQTYGSQNLKHVGVILQRSALVLL 124
Cdd:COG2244  12 LLGQLLGALLGFLLLPLLARlLGPEEYGLFALALSIVALLSVLADLGLSTA----LVRFIAEYREEELRRLLSTALLLRL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 125 LCCFPCWALFLNTQHILLLFRQDPDVsrltQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYL 204
Cdd:COG2244  88 LLSLLLALLLLLLAPFIAALLGEPEL----ALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLLLALL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 205 FLhqlhlgvigsalanlisqytlalllflyilgkklhqatWGGWSLeclqdWASFLRLAIPSMLMLCMEWWAYEVGSF-L 283
Cdd:COG2244 164 LA--------------------------------------LLGLGL-----WGLVLKYSLPLLLSGLLGLLLTNLDRLlL 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 284 SGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGY 363
Cdd:COG2244 201 GALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLS 280

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 364 IFTTDRDIInlVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGyyvVGLPIGIALMFATTLGVMGLWSGII 443
Cdd:COG2244 281 LLFGPEYAE--AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIG---AVLNLVLNLLLIPRYGLVGAAIATL 355

                       410
                ....*....|.
gi 22907060 444 ICTVFQAVCFL 454
Cdd:COG2244 356 LSYLVLLLLLL 366
MATE_like_6 cd13146
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 87-450 2.02e-08

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240551 [Multi-domain]  Cd Length: 433  Bit Score: 56.64  E-value: 2.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  87 SVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWAL-FLNTQHILLLFRQDPDVSRLTQTYVTIFIPAL 165
Cdd:cd13146  61 ALGNGIQVGVSSLLARAIGAQRAKELDQAADSGLALALLAATVIVVLgYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGV 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 166 PATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKK----LH 241
Cdd:cd13146 141 PFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKsnvtIH 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 242 QA-TWGGWSLeclqdWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRV 320
Cdd:cd13146 221 IKlSNISSSV-----IVEILRVGLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIA 295

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 321 GNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLR 400
Cdd:cd13146 296 GQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQ 375

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 22907060 401 GSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQA 450
Cdd:cd13146 376 AIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSANFFTA 425
MATE_like_3 cd13148
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 260-454 8.53e-07

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240553 [Multi-domain]  Cd Length: 441  Bit Score: 51.50  E-value: 8.53e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 260 LRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAG-FSVAASVRVGNALGAGDMEQARKSSTV 338
Cdd:cd13148  15 LRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTQMMSNGaMGGGVSSAIARALGAGDRERAEALVWH 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 339 SLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVnTIGYYV 418
Cdd:cd13148  95 ALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALV-TLVGAV 173

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 22907060 419 VGLPIGIALMF----ATTLGVMGLWSGIIICTVFQAVCFL 454
Cdd:cd13148 174 VQIPLSPGLILgwgpLPRLGVAGAAVAAVLYYALAALVLL 213
MATE_like_1 cd13140
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 260-464 1.84e-06

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240545 [Multi-domain]  Cd Length: 435  Bit Score: 50.60  E-value: 1.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 260 LRLAIPSMLMLCME--------WWAYEVGSflsgilgmvelGAQSIVYELAIIVYMVPAGFSVA---ASVRVGNALGAGD 328
Cdd:cd13140   8 LRLALPIMGTSFIQmaynltdmFWVGRLGS-----------DAVAAVGTAGFFVWLAYALALLSkigAQVKVSQSIGAKD 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 329 MEQARKSSTVSLLITVLFAVAFSVLLLSCKDhvGYIfttdrDIINLVAQVVPIYAVSHLFeALACTS---------GGVL 399
Cdd:cd13140  77 EKEARKYARNALQLNLLLGILYGLLLLLFAK--PLI-----GFFNLGDAEVISLAITYLR-IVALGLifsflnpvfTGIF 148

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22907060 400 RGSGNQKVGAIVNTIGyyvVGL-----PIgiaLMF----ATTLGVMglwsGIIICTVF-QAVCFLGFIIQLNWKK 464
Cdd:cd13140 149 NALGDSKTPFIINAIG---LVLniildPL---LIFgfgpFPALGVA----GAALATVLaQAIVFLLFLYALKKKK 213
MATE_like_13 cd13141
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 38-451 3.44e-06

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240546 [Multi-domain]  Cd Length: 443  Bit Score: 49.62  E-value: 3.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  38 LLVLAGP---AFLVQLMVFLISFIssvFCGHLGKLELDAVTLA----IAVINVTGVsvgfgLSSACDTLISQTYGSQNLK 110
Cdd:cd13141  13 IISMALPiaiGMIIQTLYFLVDLY---FVGQLGDAALAGVSLAgnvmFFVMALTQV-----LNVGTAALVSHAVGRKDQG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 111 HVGVILQRSALVLLLCCFPCWAL-FLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIV 189
Cdd:cd13141  85 EANAVFNQSLLLAAVLGLVVLVLgYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMV 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 190 TGVAANLVNALANYLFLHQL----HLGVIGSALANLISQYTLALLLFL-YILGKKLHQATWGGWSLEcLQDWASFLRLAI 264
Cdd:cd13141 165 IQILAVLLNIILAPILITGWgtgrALGVAGAGLASSISVAIAVVLLLYyFLRLEKYLRLDLALWRPD-LPTWKRLLKIGL 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 265 PS----MLMLC---MEWWAY-EVGS-----FLSG--ILGMVELGAQSIVYELAIIvymvpagfsvaasvrVGNALGAGDM 329
Cdd:cd13141 244 PSggefLLTFVymaVIYWALrPFGAaaqagFGIGsrIMQSLFLPAMAIAFAAPAI---------------AGQNFGAGNY 308

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 330 EQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGA 409
Cdd:cd13141 309 DRVRETFRITAILTTALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSL 388

                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 22907060 410 IVNTIGYYVVGLPIgIALMFATTLGVMGLWSGIIICTVFQAV 451
Cdd:cd13141 389 LSSASRLLTFALPV-IWLSAQPDFRIEQIWYLSVATTILQAA 429
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 26-173 6.00e-06

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 48.66  E-value: 6.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  26 LRLSAFREELRALLVLAGPAFLVQLMvflISFISSVFCGHLGKLELDAVTLAIAVIN-VTGVS--VGFGLSSACDTLISQ 102
Cdd:cd13143 216 LRFKLSLKIIKEILALGFPSFLMQLS---SSVVTIVLNLTLLGYGGDIGVAAFGIVTrILTFLflPLIGLSQGLQPIIGY 292

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22907060 103 TYGSQNLKHVGVILQRSALVLLLCCFPCWA-LFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYML 173
Cdd:cd13143 293 NYGAGNYDRVKQALKLALIVALIYGLVLFLiLLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIV 364
MATE_like_5 cd13145
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 86-454 6.26e-06

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240550 [Multi-domain]  Cd Length: 440  Bit Score: 48.75  E-value: 6.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  86 VSVGFGLSSACDTLISQTYGSQNLKHV-GVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYV-TIFIp 163
Cdd:cd13145  58 IAIGVGIGTGTTALIGNALGAGDRRKArRYAAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMdVIFA- 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 164 alpATFLYMLQvkYLLNqGIVLPQIVTGVAAN------LVNALANYLFLH----QLHLGVIGSALANLISQYTLALLLFL 233
Cdd:cd13145 137 ---GSIFFLLN--FGLN-GILNAQGDTKSYRNfliigfFLNIILDPLFIFggggIPAMGVSGIALATIISQFIGMFYLLY 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 234 YILGKKLHQATWGGWSLECLQDWASFLRLAIPSML-MLCMEWWAYEVGSFLSGiLGMVELGAQSIVYELAIIVYMVPAGF 312
Cdd:cd13145 211 KVRKSGIISGCRLRDFIPRLDVYKEILKQGFPASLnMMTIGLGIFVITYFVGQ-FGDEAVAAYGIALRIEQILLLPTIGL 289

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 313 SVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQ-------VVPIYAVs 385
Cdd:cd13145 290 NTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGylridalIFYAYVV- 368

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22907060 386 hLFealacTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFL 454
Cdd:cd13145 369 -LF-----ISVSVLQGLKRPIFALWIGLYRQLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIAL 431
vmrA PRK09575
MATE family efflux transporter;
58-447 2.64e-05

MATE family efflux transporter;


Pssm-ID: 236576 [Multi-domain]  Cd Length: 453  Bit Score: 46.91  E-value: 2.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060   58 ISSVFCGH-LGKLELDAVTLAIAVInvtGVSVGFGLSSACDT--LISQTYGSQNLKHVGVILQrSALVLLLCCFPCWA-- 132
Cdd:PRK09575  34 VDGIFIGHyVGAEGLAGINMAWPVI---GIILGIGLMVGMGTgsLLSIKRGEGDLEKAKRILT-TGLLLLLLLGPIVSvi 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  133 LFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIvlPQIVTG--VAANLVNALANYLFLHQLH 210
Cdd:PRK09575 110 LFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDES--PNLATGlmVIGALINIVLDYLFIGWLD 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  211 LGVIGSALANLISQYTlallLFLYILGKKLHQATWGGWSLECLQ-DWASFLRLAIPSMLMLCMewwaYEVGSF---LSGI 286
Cdd:PRK09575 188 WGLTGAAIATALAQLV----VTVLGLGYFFSSRANIRLTLKELRfNWSLAPKIVLLGSSSFFM----YLYGSFvvaLHNR 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  287 LGM-----VELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLL-LSCKDH 360
Cdd:PRK09575 260 LFMeygsaLTVGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTVLAGIAWVLLLnLFPETM 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  361 VGYIFTTDRDIINlvAQVVPIYAvsHLFeALACTSGGVLRG----SGNQKVGAIVNTIGYYVVGLPIgiaLMF-ATTLGV 435
Cdd:PRK09575 340 IALFNSGDSELIA--ETIVGIRL--HLF-AMFLDGFLVLASayfmAVNQGGKALFISIGNMLIQLPF---LFIlPKWLGV 411

                        410
                 ....*....|....*..
gi 22907060  436 MGLW-----SGIIICTV 447
Cdd:PRK09575 412 DGVWlamplSNIALSLV 428
MATE_MJ0709_like cd13147
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ...
 36-458 3.78e-05

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240552 [Multi-domain]  Cd Length: 441  Bit Score: 46.38  E-value: 3.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  36 RALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKHVGVI 115
Cdd:cd13147   9 KAIIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMII-IGLGNGLGAGASSAISRRIGAKDKEGADNA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 116 LQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAAN 195
Cdd:cd13147  88 AVHSILLGLIISIILTIVLLPFLEPILVLMGAGEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGS 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 196 LVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKK-------LHQATwggWSLECLQDwasFLRLAIPSML 268
Cdd:cd13147 168 ILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVKKdtyvslsLKNFK---FDKKIVKD---ILKVGIPASL 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 269 -MLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFA 347
Cdd:cd13147 242 eQLIMSVLMIILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIE 321

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 348 VAFSVLLLSCKDHVGYIFTTDRDIINLVAQVV---PIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIgyYVVGLPIG 424
Cdd:cd13147 322 LIIAILIFIFAPQIAYLFTYSEESAHLAPEIVaflRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITIL--RELIFQVL 399

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 22907060 425 IALMFATTL--GVMGLWSGIIICTVfqAVCFLGFII 458
Cdd:cd13147 400 FAYLFAIVLglGLFGVWWGIVLGNA--IGSIVGYLW 433
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 32-226 5.59e-05

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 45.58  E-value: 5.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  32 REELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTgVSVGFGLSSACDTLISQTYGSQNLKH 111
Cdd:cd13137 222 RKIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLA-FMPGFGFSMAASTLVGQNLGAGDPDE 300

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 112 VGVILQRSAL--VLLLCCFpCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIV 189
Cdd:cd13137 301 ARRYGKRALRlgVLFMGLL-GLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLI 379

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 22907060 190 TGVAANLVNALA-NYLFLHQLHLGVIGSALANLISQYT 226
Cdd:cd13137 380 INLISMWLVRLPlAYLLGFVLGLGLTGIWLAMFVDTIV 417
MurJ COG0728
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ...
 26-308 9.04e-04

Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440492 [Multi-domain]  Cd Length: 503  Bit Score: 42.06  E-value: 9.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  26 LRLSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGkleldavTLAIAVIN--------VTGVsVGFGLSSACD 97
Cdd:COG0728 212 PRFDLRDPGVRRVLKLMLPALLGVSVSQINLLVDTILASFLP-------EGSVSALYyadrlyqlPLGL-FGVAIGTALL 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060  98 TLISQTYGSQNLKHVGVILQRSALVLLLCCFPC--WALFLNTQHILLLF---RQDPDVSRLTQTYVTIFIPALPATFLYM 172
Cdd:COG0728 284 PRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAavGLIVLAEPIVRLLFergAFTAEDTALTALALAAYALGLPAFALVK 363

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907060 173 LQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHqlHLGVIGSALANLISqYTLALLLFLYILGKKLHQATWGGWslec 252
Cdd:COG0728 364 VLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVP--PLGHAGLALATSLS-ALVNALLLLVLLRRRLGGLPLRGI---- 436

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22907060 253 lqdWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMV 308
Cdd:COG0728 437 ---LRTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFA 489
MATE_like_5 cd13145
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 279-354 8.79e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240550 [Multi-domain]  Cd Length: 440  Bit Score: 38.73  E-value: 8.79e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22907060 279 VGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKsstvSLLITVLFAVAFSVLL 354
Cdd:cd13145  31 VDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARR----YAAQGLSFGIILAILL 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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