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Conserved domains on  [gi|228312204]
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Chain G, 50S ribosomal protein L10E

Protein Classification

50S ribosomal protein L10( domain architecture ID 11480103)

50S ribosomal protein L10 binds and anchors the two L7/L12 dimers to the large ribosomal subunit

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rplP0 PRK04019
acidic ribosomal protein P0; Validated
 9-311 3.07e-154

acidic ribosomal protein P0; Validated


:

Pssm-ID: 179712 [Multi-domain]  Cd Length: 330  Bit Score: 436.22  E-value: 3.07e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204   9 TETIPEWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGTAELRVSRNTLLERALDDVD-DGLEDLNGYITG 87
Cdd:PRK04019   1 TEHVPEWKKEEVEELKELIKSYPVVGIVDLEGIPARQLQEIRRKLRGKAELKVSKNTLIKRALEEAGeEDLEKLEDYLEG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  88 QVGLIGTDDNPFSLFQELEASKTPAPIGAGEVAPNDIVIPEGDTGVDPGPFVGELQSVGADARIQEGSIQVLSDSTVLDT 167
Cdd:PRK04019  81 QVALIFTNMNPFKLYKLLEKSKTPAPAKPGDIAPEDIVVPAGPTGFPPGPILSELQKLGIPARIQKGKIVIKKDTVVAKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204 168 GEEVSQELSNVLNELGIEPKEVGLDLRAVFADGVLFEPEELELDIDEYRSDIQAAAGRAFNLSVNADYPTATTAPTMLQS 247
Cdd:PRK04019 161 GEVISPELANVLQKLGIKPIEVGLDLKAAYEDGVIYTPEVLAIDEEKYRSDIQEAAQNAFNLAVNAAYPTPETLETLIQK 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 228312204 248 ARGNAKSLALQAAIEDPEVVPDLVSKADAQVRALASQIDDEEALPEELQGVEADVATEEPTDDQ 311
Cdd:PRK04019 241 AFREAKALAVEAGIVTPETADDILSKAVAQALALAAALADKDALDEELKEVLSAQAQAAAAEEE 304
 
Name Accession Description Interval E-value
rplP0 PRK04019
acidic ribosomal protein P0; Validated
 9-311 3.07e-154

acidic ribosomal protein P0; Validated


Pssm-ID: 179712 [Multi-domain]  Cd Length: 330  Bit Score: 436.22  E-value: 3.07e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204   9 TETIPEWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGTAELRVSRNTLLERALDDVD-DGLEDLNGYITG 87
Cdd:PRK04019   1 TEHVPEWKKEEVEELKELIKSYPVVGIVDLEGIPARQLQEIRRKLRGKAELKVSKNTLIKRALEEAGeEDLEKLEDYLEG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  88 QVGLIGTDDNPFSLFQELEASKTPAPIGAGEVAPNDIVIPEGDTGVDPGPFVGELQSVGADARIQEGSIQVLSDSTVLDT 167
Cdd:PRK04019  81 QVALIFTNMNPFKLYKLLEKSKTPAPAKPGDIAPEDIVVPAGPTGFPPGPILSELQKLGIPARIQKGKIVIKKDTVVAKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204 168 GEEVSQELSNVLNELGIEPKEVGLDLRAVFADGVLFEPEELELDIDEYRSDIQAAAGRAFNLSVNADYPTATTAPTMLQS 247
Cdd:PRK04019 161 GEVISPELANVLQKLGIKPIEVGLDLKAAYEDGVIYTPEVLAIDEEKYRSDIQEAAQNAFNLAVNAAYPTPETLETLIQK 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 228312204 248 ARGNAKSLALQAAIEDPEVVPDLVSKADAQVRALASQIDDEEALPEELQGVEADVATEEPTDDQ 311
Cdd:PRK04019 241 AFREAKALAVEAGIVTPETADDILSKAVAQALALAAALADKDALDEELKEVLSAQAQAAAAEEE 304
Ribosomal_P0_L10e cd05795
Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal ...
 14-186 1.05e-77

Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These eukaryotic and archaeal P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 240221 [Multi-domain]  Cd Length: 175  Bit Score: 235.93  E-value: 1.05e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  14 EWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGTAELRVSRNTLLERALDDVDDGLEDLN---GYITGQVG 90
Cdd:cd05795    1 EWKKEYVEKLTELLKSYPKVLIVDADNVGSKQLQKIRRSLRGKAEILMGKNTLIRRALRNLGDENPELEkllPYLKGNVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  91 LIGTDDNPFSLFQELEASKTPAPIGAGEVAPNDIVIPEGDTGVDPGPFVgELQSVGADARIQEGSIQVLSDSTVLDTGEE 170
Cdd:cd05795   81 FIFTNGDPFEIRKILEENKVPAPAKPGAIAPCDVVVPAGPTGMPPGPTS-FFQALGIPTKIEKGKIEIISDVVVVKKGEK 159

                        170
                 ....*....|....*.
gi 228312204 171 VSQELSNVLNELGIEP 186
Cdd:cd05795  160 VGASEATLLNKLNIKP 175
Ribosomal_L10 pfam00466
Ribosomal protein L10;
12-107 2.99e-25

Ribosomal protein L10;


Pssm-ID: 459822 [Multi-domain]  Cd Length: 99  Bit Score: 97.61  E-value: 2.99e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204   12 IPEWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGT-AELRVSRNTLLERALDdvDDGLEDLNGYITGQVG 90
Cdd:pfam00466   2 TREKKEELVEELKELLKEYKSVVVVDYRGLTVAQLTELRKKLRENgAELKVGKNTLMRRALE--ETGEEKLEDYLKGPTA 79

                          90
                  ....*....|....*..
gi 228312204   91 LIGTDDNPFSLFQELEA 107
Cdd:pfam00466  80 LLFTNEDPVAVAKVLED 96
RplJ COG0244
Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 ...
 16-98 4.80e-10

Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440014  Cd Length: 172  Bit Score: 57.77  E-value: 4.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  16 KQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGT-AELRVSRNTLLERALDDVddGLEDLNGYITGQVGLIGT 94
Cdd:COG0244    6 KKAVVAELKEKLKEAQAVVLTDYRGLTVAQMTELRRKLREAgVEYKVVKNTLARIALEGT--GFEGLDDLLKGPTAIAFS 83


                 ....
gi 228312204  95 DDNP 98
Cdd:COG0244   84 YEDP 87
 
Name Accession Description Interval E-value
rplP0 PRK04019
acidic ribosomal protein P0; Validated
 9-311 3.07e-154

acidic ribosomal protein P0; Validated


Pssm-ID: 179712 [Multi-domain]  Cd Length: 330  Bit Score: 436.22  E-value: 3.07e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204   9 TETIPEWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGTAELRVSRNTLLERALDDVD-DGLEDLNGYITG 87
Cdd:PRK04019   1 TEHVPEWKKEEVEELKELIKSYPVVGIVDLEGIPARQLQEIRRKLRGKAELKVSKNTLIKRALEEAGeEDLEKLEDYLEG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  88 QVGLIGTDDNPFSLFQELEASKTPAPIGAGEVAPNDIVIPEGDTGVDPGPFVGELQSVGADARIQEGSIQVLSDSTVLDT 167
Cdd:PRK04019  81 QVALIFTNMNPFKLYKLLEKSKTPAPAKPGDIAPEDIVVPAGPTGFPPGPILSELQKLGIPARIQKGKIVIKKDTVVAKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204 168 GEEVSQELSNVLNELGIEPKEVGLDLRAVFADGVLFEPEELELDIDEYRSDIQAAAGRAFNLSVNADYPTATTAPTMLQS 247
Cdd:PRK04019 161 GEVISPELANVLQKLGIKPIEVGLDLKAAYEDGVIYTPEVLAIDEEKYRSDIQEAAQNAFNLAVNAAYPTPETLETLIQK 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 228312204 248 ARGNAKSLALQAAIEDPEVVPDLVSKADAQVRALASQIDDEEALPEELQGVEADVATEEPTDDQ 311
Cdd:PRK04019 241 AFREAKALAVEAGIVTPETADDILSKAVAQALALAAALADKDALDEELKEVLSAQAQAAAAEEE 304
Ribosomal_P0_L10e cd05795
Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal ...
 14-186 1.05e-77

Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These eukaryotic and archaeal P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 240221 [Multi-domain]  Cd Length: 175  Bit Score: 235.93  E-value: 1.05e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  14 EWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGTAELRVSRNTLLERALDDVDDGLEDLN---GYITGQVG 90
Cdd:cd05795    1 EWKKEYVEKLTELLKSYPKVLIVDADNVGSKQLQKIRRSLRGKAEILMGKNTLIRRALRNLGDENPELEkllPYLKGNVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  91 LIGTDDNPFSLFQELEASKTPAPIGAGEVAPNDIVIPEGDTGVDPGPFVgELQSVGADARIQEGSIQVLSDSTVLDTGEE 170
Cdd:cd05795   81 FIFTNGDPFEIRKILEENKVPAPAKPGAIAPCDVVVPAGPTGMPPGPTS-FFQALGIPTKIEKGKIEIISDVVVVKKGEK 159

                        170
                 ....*....|....*.
gi 228312204 171 VSQELSNVLNELGIEP 186
Cdd:cd05795  160 VGASEATLLNKLNIKP 175
PTZ00135 PTZ00135
60S acidic ribosomal protein P0; Provisional
 14-294 4.98e-47

60S acidic ribosomal protein P0; Provisional


Pssm-ID: 240285 [Multi-domain]  Cd Length: 310  Bit Score: 161.72  E-value: 4.98e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  14 EWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGTAELRVSRNTLLERAL----DDVDDgLEDLNGYITGQV 89
Cdd:PTZ00135   8 AKKKAYFEKLYELLEKYKKILIVSVDNVGSKQMQDIRRSLRGKAELLMGKNTLIRKALkqrlEELPE-LEKLLPHVKGNV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  90 GLIGTDDNPFSLFQELEASKTPAPIGAGEVAPNDIVIPEGDTGVDPGPfVGELQSVGADARIQEGSIQVLSDSTVLDTGE 169
Cdd:PTZ00135  87 GFVFTKDDLFEVKPVILENKVPAPARAGVIAPIDVVIPAGPTGMDPSQ-TSFFQALGIATKIVKGQIEITNEVHLIKEGQ 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204 170 EVSQELSNVLNELGIEPKEVGLDLRAVFADGVLFEPEELELDIDEYRSDIQAAAGRAFNLSVNADYPTATTAPTMLQSAR 249
Cdd:PTZ00135 166 KVGASQAVLLQKLNIKPFSYGLEVLSIYDNGSIYDAKVLDITDEDIVAKFQEGVQNVAAISLAAGYPTEASAPHSILNAF 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 228312204 250 GNAKSLALQ------------AAIEDPEVVPDLVSKADAQVRAlASQIDDEEALPEE 294
Cdd:PTZ00135 246 KNLAAIGLEsgftfplaekikEALANPSAAAAAAAAAAAAAAA-AAAAPAEEEEEEE 301
Ribosomal_L10_P0 cd00379
Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in ...
 14-137 2.77e-26

Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in bacteria, P0 in eukaryotes, and L10e in archaea, as well as uncharacterized P0-like eukaryotic proteins. In all three kingdoms, L10 forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). Some eukaryotic P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 238222 [Multi-domain]  Cd Length: 155  Bit Score: 102.26  E-value: 2.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  14 EWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGT-AELRVSRNTLLERALDdvDDGLEDLNGYITGQVGLI 92
Cdd:cd00379    1 EKKEELVEELKELLKKYKSVVVVDYRGLTVAQLTELRKELRESgAKLKVGKNTLMRRALK--GTGFEELKPLLKGPTALA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 228312204  93 GTDDNPFSLFQELEASKTP---APIGAGEVApNDIVIPEGDTGVDPGP 137
Cdd:cd00379   79 FTNEDPVEVAKVLKDFAKEnkkLFAKGGVVA-GKVLDPAGVTALAKLP 125
Ribosomal_L10 pfam00466
Ribosomal protein L10;
12-107 2.99e-25

Ribosomal protein L10;


Pssm-ID: 459822 [Multi-domain]  Cd Length: 99  Bit Score: 97.61  E-value: 2.99e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204   12 IPEWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGT-AELRVSRNTLLERALDdvDDGLEDLNGYITGQVG 90
Cdd:pfam00466   2 TREKKEELVEELKELLKEYKSVVVVDYRGLTVAQLTELRKKLRENgAELKVGKNTLMRRALE--ETGEEKLEDYLKGPTA 79

                          90
                  ....*....|....*..
gi 228312204   91 LIGTDDNPFSLFQELEA 107
Cdd:pfam00466  80 LLFTNEDPVAVAKVLED 96
PTZ00240 PTZ00240
60S ribosomal protein P0; Provisional
 11-248 1.22e-24

60S ribosomal protein P0; Provisional


Pssm-ID: 140267 [Multi-domain]  Cd Length: 323  Bit Score: 101.96  E-value: 1.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  11 TIPEWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGTAELRVSRNTL----LERALDDVDDGLEDLNGY-- 84
Cdd:PTZ00240   3 SITTAKREYEERLVDCLTKYSCVLFVGMDNVRSQQVHDVRRALRGKAEFVMGKKTLqakiVEKRAQAKKASAEAKLFNdq 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  85 ------ITGQVGLIGTDDNPFSLFQELEASKTPAPIGAGEVAPNDIVIPEGDTGVDPGPfVGELQSVGADARIQEGSIQV 158
Cdd:PTZ00240  83 ceeknlLSGNTGLIFTNNEVQEITSVLDSHRVKAPARVGAIAPCDVIVPAGSTGMEPTQ-TSFFQALNIATKIAKGMVEI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204 159 LSDSTVLDTGEEVSQELSNVLNELGIEPKEVGLDLRAVFADGVLFEPEELELDIDEYRSDIQAAAGRAFNLSVNADYPTA 238
Cdd:PTZ00240 162 VTEKKVLSVGDKVDNSTATLLQKLNISPFYYQVEVLSVWDRGVLFTREDLSMTEDVVEKMLMEGLSNVAAMSLGAGIPTA 241

                        250
                 ....*....|
gi 228312204 239 TTAPTMLQSA 248
Cdd:PTZ00240 242 ATIGPMLVDA 251
RL10P_insert pfam17777
Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and ...
 116-184 2.49e-13

Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and archaeal ribosomal L10 protein.


Pssm-ID: 465500 [Multi-domain]  Cd Length: 71  Bit Score: 64.15  E-value: 2.49e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 228312204  116 AGEVAPNDIVIPEGDTGVDPGPFVGELQSVGADARIQEGSIQVLSDSTVLDTGEEVSQELSNVLNELGI 184
Cdd:pfam17777   3 AGAIATEDVVLPAGPTGLAPGPIEPQLRALGIPTKIKKGKIEITKDYTVCKEGEKLTPEQANLLKLLGI 71
Ribosomal_P0_like cd05796
Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized ...
 14-172 1.49e-12

Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be involved in mRNA decay. P0 forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. It occupies the L7/L12 stalk of the ribosome. The stalk is known to contain the binding site for elongation factors EF-G and EF-Tu; however, there is disagreement as to whether or not P0 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, P0 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). Some eukaryotic P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 240222 [Multi-domain]  Cd Length: 163  Bit Score: 64.91  E-value: 1.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  14 EWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGTaELRVSRNTLLERAL-----DDVDDGLEDLNGYITGQ 88
Cdd:cd05796    1 ELKQKLVENIREAVDKYKYIYVFSVDNMRNNKLKDIRQEWKDS-RFFFGKNKVMQVALgrtpeDEYKPNLHKLSKYLKGQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  89 VGLIGTDDNPFSLFQELEASKTPAPIGAGEVAPNDIVIPEGDTGVDPGPFVGELQSVGADARIQEGSIQVLSDSTVLDTG 168
Cdd:cd05796   80 VGLLFTNEPPEEVIEYFDSYSEPDFARAGSIATETVTLPEGPLEQFPHSMEPQLRKLGLPTKLKKGVITLEADYVVCEEG 159


                 ....
gi 228312204 169 EEVS 172
Cdd:cd05796  160 KVLT 163
Ribosomal_L10 cd05797
Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and ...
 16-100 3.75e-11

Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These bacteria and eukaryotic sequences have no additional C-terminal domain, present in other eukaryotic and archaeal orthologs.


Pssm-ID: 240223  Cd Length: 157  Bit Score: 60.60  E-value: 3.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  16 KQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGT-AELRVSRNTLLERALDDVddGLEDLNGYITGQVGLIGT 94
Cdd:cd05797    5 KEEIVAELKEKLKEAKSVVVADYRGLTVAQLTELRKELREAgVKLKVVKNTLAKRALEGT--GFEDLDDLLKGPTAIAFS 82


                 ....*.
gi 228312204  95 DDNPFS 100
Cdd:cd05797   83 EEDPVA 88
RplJ COG0244
Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 ...
 16-98 4.80e-10

Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440014  Cd Length: 172  Bit Score: 57.77  E-value: 4.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  16 KQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGT-AELRVSRNTLLERALDDVddGLEDLNGYITGQVGLIGT 94
Cdd:COG0244    6 KKAVVAELKEKLKEAQAVVLTDYRGLTVAQMTELRRKLREAgVEYKVVKNTLARIALEGT--GFEGLDDLLKGPTAIAFS 83


                 ....
gi 228312204  95 DDNP 98
Cdd:COG0244   84 YEDP 87
rplJ PRK00099
50S ribosomal protein L10; Reviewed
 16-96 1.22e-08

50S ribosomal protein L10; Reviewed


Pssm-ID: 234632  Cd Length: 172  Bit Score: 53.61  E-value: 1.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228312204  16 KQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGT-AELRVSRNTLLERALDDVddGLEDLNGYITGQVGLI-G 93
Cdd:PRK00099   6 KKEIVAELAEKLKKAQSAVVADYRGLTVAQMTELRKKLREAgVEYKVVKNTLARRALEGT--GFEGLDDLLKGPTAIAfS 83


                 ...
gi 228312204  94 TDD 96
Cdd:PRK00099  84 YED 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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