NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|227452255|ref|NP_060364|]
View 

zinc finger and SCAN domain-containing protein 2 isoform 2 [Homo sapiens]

Protein Classification

SCAN domain-containing protein( domain architecture ID 10488381)

SCAN domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 72-134 8.74e-29

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


:

Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 101.03  E-value: 8.74e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 227452255   72 GPQGALGRLRELCRRWLRPEVHTKEQM---------LTMLPKEIQAWLQEHRPESSEEAAALVEDLTQTLQD 134
Cdd:pfam02023  18 GPREALSQLRELCHQWLRPEKHTKEQIlellvleqfLTILPEEIQSWVREHHPESGEEAVALAEDLLLERGE 89
 
Name Accession Description Interval E-value
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 72-134 8.74e-29

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 101.03  E-value: 8.74e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 227452255   72 GPQGALGRLRELCRRWLRPEVHTKEQM---------LTMLPKEIQAWLQEHRPESSEEAAALVEDLTQTLQD 134
Cdd:pfam02023  18 GPREALSQLRELCHQWLRPEKHTKEQIlellvleqfLTILPEEIQSWVREHHPESGEEAVALAEDLLLERGE 89
SCAN smart00431
leucine rich region;
70-141 4.67e-26

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 95.06  E-value: 4.67e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227452255    70 TRGPQGALGRLRELCRRWLRPEVHTKEQML---------TMLPKEIQAWLQEHRPESSEEAAALVEDLTQTLQDSAVAVV 140
Cdd:smart00431  16 TSGPREALSRLRELCRQWLRPELHTKEQILellvleqflTILPGELQAWVREHHPESGEEAVTLLEDLERELDEPGQQVS 95


                   .
gi 227452255   141 A 141
Cdd:smart00431  96 A 96
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 72-130 1.28e-22

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 85.39  E-value: 1.28e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 227452255  72 GPQGALGRLRELCRRWLRPEVHTKEQM---------LTMLPKEIQAWLQEHRPESSEEAAALVEDLTQ 130
Cdd:cd07936   18 GPREALQRLRELCRQWLRPEIHTKEQIlellvleqfLIILPPEVQAWVRERKPESGEEAATLAEDLLA 85
 
Name Accession Description Interval E-value
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 72-134 8.74e-29

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 101.03  E-value: 8.74e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 227452255   72 GPQGALGRLRELCRRWLRPEVHTKEQM---------LTMLPKEIQAWLQEHRPESSEEAAALVEDLTQTLQD 134
Cdd:pfam02023  18 GPREALSQLRELCHQWLRPEKHTKEQIlellvleqfLTILPEEIQSWVREHHPESGEEAVALAEDLLLERGE 89
SCAN smart00431
leucine rich region;
70-141 4.67e-26

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 95.06  E-value: 4.67e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227452255    70 TRGPQGALGRLRELCRRWLRPEVHTKEQML---------TMLPKEIQAWLQEHRPESSEEAAALVEDLTQTLQDSAVAVV 140
Cdd:smart00431  16 TSGPREALSRLRELCRQWLRPELHTKEQILellvleqflTILPGELQAWVREHHPESGEEAVTLLEDLERELDEPGQQVS 95


                   .
gi 227452255   141 A 141
Cdd:smart00431  96 A 96
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 72-130 1.28e-22

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 85.39  E-value: 1.28e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 227452255  72 GPQGALGRLRELCRRWLRPEVHTKEQM---------LTMLPKEIQAWLQEHRPESSEEAAALVEDLTQ 130
Cdd:cd07936   18 GPREALQRLRELCRQWLRPEIHTKEQIlellvleqfLIILPPEVQAWVRERKPESGEEAATLAEDLLA 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH