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Conserved domains on  [gi|227343670]
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Chain B, SLIT HOMOLOG 2 PROTEIN C-PRODUCT

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
13-138 1.02e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  13 TVVRCSNKGLKVLPKGIPR--DVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNqSFSNMTQLLTLILSYNRL 90
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI 194

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 227343670  91 RCIPPrTFDGLKSLRLLSLHGNDISVVPEgAFNDLSALSHLAIGANPL 138
Cdd:COG4886  195 TDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQL 240
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 109-184 5.00e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.87  E-value: 5.00e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 227343670   109 LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE---YKEPGIARCAGPGEMADKLLLTTPSKKFTC 184
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvkVRQPEAALCAGPGALAGQPLLGIPLLDSGC 80
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
13-138 1.02e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  13 TVVRCSNKGLKVLPKGIPR--DVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNqSFSNMTQLLTLILSYNRL 90
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI 194

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 227343670  91 RCIPPrTFDGLKSLRLLSLHGNDISVVPEgAFNDLSALSHLAIGANPL 138
Cdd:COG4886  195 TDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
55-114 4.63e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.09  E-value: 4.63e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670   55 HLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDI 114
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 31-131 4.63e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 4.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  31 RDVTELYLDGNQFTLVPkELSNYKHLTLIDLSNNRISTLSNqsFSNMTQLLTLILSYNRLRCIPPrtFDGLKSLRLLSLH 110
Cdd:cd21340    2 KRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                         90       100
                 ....*....|....*....|.
gi 227343670 111 GNDISVVpEGaFNDLSALSHL 131
Cdd:cd21340   77 GNRISVV-EG-LENLTNLEEL 95
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 109-184 5.00e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.87  E-value: 5.00e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 227343670   109 LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE---YKEPGIARCAGPGEMADKLLLTTPSKKFTC 184
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvkVRQPEAALCAGPGALAGQPLLGIPLLDSGC 80
PLN03150 PLN03150
hypothetical protein; Provisional
 46-115 2.72e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 58.67  E-value: 2.72e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  46 VPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDIS 115
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
LRRCT smart00082
Leucine rich repeat C-terminal domain;
136-184 2.12e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 2.12e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 227343670   136 NPLYCDCNMQWLSDWVKSE--YKEPGIARCAGPGEMADKLLLTTPSkKFTC 184
Cdd:smart00082   1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGPLLELLHS-EFKC 50
LRRNT smart00013
Leucine rich repeat N-terminal domain;
4-35 4.19e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.62  E-value: 4.19e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 227343670     4 CPTECTCLDTVVRCSNKGLKVLPKGIPRDVTE 35
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
13-138 1.02e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  13 TVVRCSNKGLKVLPKGIPR--DVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNqSFSNMTQLLTLILSYNRL 90
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI 194

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 227343670  91 RCIPPrTFDGLKSLRLLSLHGNDISVVPEgAFNDLSALSHLAIGANPL 138
Cdd:COG4886  195 TDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
13-138 4.08e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 4.08e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  13 TVVRCSNKGLKVLPKGIPR--DVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNqSFSNMTQLLTLILSYNRL 90
Cdd:COG4886  139 KELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL 217

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 227343670  91 RCIPPrTFDGLKSLRLLSLHGNDISVVPEgaFNDLSALSHLAIGANPL 138
Cdd:COG4886  218 TDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-138 3.20e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  32 DVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNqSFSNMTQLLTLILSYNRLRCIPPrTFDGLKSLRLLSLHG 111
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSN 191

                         90       100
                 ....*....|....*....|....*..
gi 227343670 112 NDISVVPEgAFNDLSALSHLAIGANPL 138
Cdd:COG4886  192 NQITDLPE-PLGNLTNLEELDLSGNQL 217
LRR_8 pfam13855
Leucine rich repeat;
55-114 4.63e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.09  E-value: 4.63e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670   55 HLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDI 114
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-115 1.08e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 1.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  34 TELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSnqSFSNMTQLLTLILSYNRLRCIPPrtFDGLKSLRLLSLHGND 113
Cdd:COG4886  208 EELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQ 283


                 ..
gi 227343670 114 IS 115
Cdd:COG4886  284 LT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-138 1.14e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.64  E-value: 1.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  33 VTELYLDGNqftlvpKELSNYKHLTLIDLSNNRISTLSNqSFSNMTQLLTLILSYNRLRCIPPrTFDGLKSLRLLSLHGN 112
Cdd:COG4886   98 LTELDLSGN------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN 169

                         90       100
                 ....*....|....*....|....*.
gi 227343670 113 DISVVPEgAFNDLSALSHLAIGANPL 138
Cdd:COG4886  170 QLTDLPE-ELGNLTNLKELDLSNNQI 194
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 31-131 4.63e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 4.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  31 RDVTELYLDGNQFTLVPkELSNYKHLTLIDLSNNRISTLSNqsFSNMTQLLTLILSYNRLRCIPPrtFDGLKSLRLLSLH 110
Cdd:cd21340    2 KRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                         90       100
                 ....*....|....*....|.
gi 227343670 111 GNDISVVpEGaFNDLSALSHL 131
Cdd:cd21340   77 GNRISVV-EG-LENLTNLEEL 95
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 109-184 5.00e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.87  E-value: 5.00e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 227343670   109 LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE---YKEPGIARCAGPGEMADKLLLTTPSKKFTC 184
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvkVRQPEAALCAGPGALAGQPLLGIPLLDSGC 80
PLN03150 PLN03150
hypothetical protein; Provisional
 46-115 2.72e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 58.67  E-value: 2.72e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  46 VPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDIS 115
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
10-138 3.34e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 3.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  10 CL---DTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKEL-SNYKHLT------------------LIDLSNNRIS 67
Cdd:PRK15370 175 CLknnKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLqGNIKTLYansnqltsipatlpdtiqEMELSINRIT 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 227343670  68 TLSNQSFSnmtQLLTLILSYNRLRCIPPRTFDGlksLRLLSLHGNDISVVPEgafNDLSALSHLAIGANPL 138
Cdd:PRK15370 255 ELPERLPS---ALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPA---HLPSGITHLNVQSNSL 316
LRR_8 pfam13855
Leucine rich repeat;
33-90 1.13e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 1.13e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 227343670   33 VTELYLDGNQFTLVPKE-LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRL 90
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
78-138 1.76e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.76e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 227343670   78 TQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPL 138
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
136-184 2.12e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 2.12e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 227343670   136 NPLYCDCNMQWLSDWVKSE--YKEPGIARCAGPGEMADKLLLTTPSkKFTC 184
Cdd:smart00082   1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGPLLELLHS-EFKC 50
LRRNT smart00013
Leucine rich repeat N-terminal domain;
4-35 4.19e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.62  E-value: 4.19e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 227343670     4 CPTECTCLDTVVRCSNKGLKVLPKGIPRDVTE 35
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 32-140 1.25e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  32 DVTELYLDGNQFT-LVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLH 110
Cdd:PLN00113 500 ELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNIS 579

                         90       100       110
                 ....*....|....*....|....*....|..
gi 227343670 111 GNDI--SVVPEGAFndlSALSHLAIGANPLYC 140
Cdd:PLN00113 580 HNHLhgSLPSTGAF---LAINASAVAGNIDLC 608
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 4-30 7.19e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 41.07  E-value: 7.19e-06
                          10        20
                  ....*....|....*....|....*..
gi 227343670    4 CPTECTCLDTVVRCSNKGLKVLPKGIP 30
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 34-115 7.32e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 7.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  34 TELYLD------GNQFTLVP---KELSNykHLTLIDLSNNRISTLSnqSFSNMTQLLTLILSYNRLRCIPP--RTFDGLK 102
Cdd:cd21340   93 EELHIEnqrlppGEKLTFDPrslAALSN--SLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWP 168

                         90
                 ....*....|...
gi 227343670 103 SLRLLSLHGNDIS 115
Cdd:cd21340  169 SLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 36-138 7.59e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 7.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  36 LYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDIS 115
Cdd:PLN00113 457 LSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536

                         90       100
                 ....*....|....*....|...
gi 227343670 116 VVPEGAFNDLSALSHLAIGANPL 138
Cdd:PLN00113 537 GQIPASFSEMPVLSQLDLSQNQL 559
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-138 2.27e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 2.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  29 IPRDVTEL------YLDGNQFT-LVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGL 101
Cdd:PLN00113 324 IPVALTSLprlqvlQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGAC 403

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 227343670 102 KSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPL 138
Cdd:PLN00113 404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 30-121 1.33e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  30 PRDVTELYLDGNQFT-----LVPKELSNYKHLTLIDLSNNRISTLS----NQSFSNMTQLLTLILSYNRLR---CIP-PR 96
Cdd:COG5238  263 NTTVETLYLSGNQIGaegaiALAKALQGNTTLTSLDLSVNRIGDEGaialAEGLQGNKTLHTLNLAYNGIGaqgAIAlAK 342

                         90       100
                 ....*....|....*....|....*
gi 227343670  97 TFDGLKSLRLLSLHGNDISVvpEGA 121
Cdd:COG5238  343 ALQENTTLHSLDLSDNQIGD--EGA 365
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 25-138 1.50e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  25 LPKGIPRDVTELYLDGNQFT-LVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKS 103
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKS 213

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 227343670 104 LRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPL 138
Cdd:PLN00113 214 LKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNL 248
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 36-115 2.05e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 2.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  36 LYLDGNQFT-LVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDI 114
Cdd:PLN00113 480 LDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559


                 .
gi 227343670 115 S 115
Cdd:PLN00113 560 S 560
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
13-154 4.02e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.22  E-value: 4.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  13 TVVRCSNKGLKVLP--KGIPRdVTELYLDGNQFTLVPkELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRL 90
Cdd:COG4886  231 ETLDLSNNQLTDLPelGNLTN-LEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 227343670  91 RCIPP-RTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE 154
Cdd:COG4886  309 NLLELlILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 21-138 8.83e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 36.36  E-value: 8.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227343670  21 GLKVLPKGIPRDVTE------LYLDGNQFT-LVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCI 93
Cdd:PLN00113 172 GGNVLVGKIPNSLTNltslefLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGP 251

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 227343670  94 PPRTFDGLKSLRLLSLHGNDIS-VVPEGAFNdLSALSHLAIGANPL 138
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSL 296
LRR smart00370
Leucine-rich repeats, outliers;
77-100 9.35e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 32.71  E-value: 9.35e-03
                           10        20
                   ....*....|....*....|....
gi 227343670    77 MTQLLTLILSYNRLRCIPPRTFDG 100
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
77-100 9.35e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 32.71  E-value: 9.35e-03
                           10        20
                   ....*....|....*....|....
gi 227343670    77 MTQLLTLILSYNRLRCIPPRTFDG 100
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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