NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|226823220|ref|NP_032495|]
View 

keratin, type I cytoskeletal 15 [Mus musculus]

Protein Classification

intermediate filament family protein( domain architecture ID 11981676)

intermediate filament (IF) family protein is a primordial component of the cytoskeleton and the nuclear envelope; such as type I keratins

CATH:  1.20.5.170
Gene Ontology:  GO:0005882
PubMed:  2183847|12596228|28101862

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
97-409 1.90e-140

Intermediate filament protein;


:

Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 404.69  E-value: 1.90e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   97 NEKVTMQNLNDRLASYLDKVRALEQANTELEVKIRDWYQKQSPAsPDRDYSHYFKTMEEIRDKILAATIDNSRVVLEIDN 176
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGAE-PSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220  177 ARLAADDFRLKYENELTLRQGVEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFSSQLA-GQVNVE 255
Cdd:pfam00038  80 LRLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSdTQVNVE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220  256 MDAAPGVDLTRMLAEMREQYEAIAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLSM 335
Cdd:pfam00038 160 MDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQ 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226823220  336 KAGLENSLAEVECRYATQLQQIQGVITGLETQLSELRCEMEAQNQEYNMLLDIKTRLEQEIATYRNLLEGQDAK 409
Cdd:pfam00038 240 KASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
97-409 1.90e-140

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 404.69  E-value: 1.90e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   97 NEKVTMQNLNDRLASYLDKVRALEQANTELEVKIRDWYQKQSPAsPDRDYSHYFKTMEEIRDKILAATIDNSRVVLEIDN 176
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGAE-PSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220  177 ARLAADDFRLKYENELTLRQGVEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFSSQLA-GQVNVE 255
Cdd:pfam00038  80 LRLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSdTQVNVE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220  256 MDAAPGVDLTRMLAEMREQYEAIAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLSM 335
Cdd:pfam00038 160 MDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQ 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226823220  336 KAGLENSLAEVECRYATQLQQIQGVITGLETQLSELRCEMEAQNQEYNMLLDIKTRLEQEIATYRNLLEGQDAK 409
Cdd:pfam00038 240 KASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 115-398 1.53e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.83  E-value: 1.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   115 KVRALEQANTELEVKIRDWYQKQSPASPDRDYSHyfKTMEEIRDKILAATIDNSRVVLEIDNARLAADDFRLKYENELTL 194
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELEELEEELEQLR--KELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAE 762

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   195 RQGVEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFSsqlagQVNVEMDaapgvDLTRMLAEMREQ 274
Cdd:TIGR02168  763 IEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELT-----LLNEEAA-----NLRERLESLERR 832

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   275 YEAIAEKNRRDVEAWffsktEELNKEVASNTEmiqtsktEITDLRRTLQGLEIELQSQLSMKAGLENSLAEVECRYATQL 354
Cdd:TIGR02168  833 IAATERRLEDLEEQI-----EELSEDIESLAA-------EIEELEELIEELESELEALLNERASLEEALALLRSELEELS 900

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 226823220   355 QQIQgvitGLETQLSELRCEMEAQNQEYNMLLDIKTRLEQEIAT 398
Cdd:TIGR02168  901 EELR----ELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 151-418 9.90e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.01  E-value: 9.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 151 KTMEEIRDKILAATIDNSRVVLEIDNARLAADDFRLKYENELTLRQGVEADINGLRRVLDELTLARTDLEMQIEQLNEEL 230
Cdd:COG1196  246 AELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEEL 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 231 AYLKKNHEEEMKEFSSQLAGQVNVEMDAApgvDLTRMLAEMREQYEAIAEKNRRDVEAWffsktEELNKEVASNTEMIQT 310
Cdd:COG1196  326 AELEEELEELEEELEELEEELEEAEEELE---EAEAELAEAEEALLEAEAELAEAEEEL-----EELAEELLEALRAAAE 397

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 311 SKTEITDLRRTLQGLEIELQSQLSMKAGLENSLAEVE----------CRYATQLQQIQGVITGLETQLSELRCEMEAQNQ 380
Cdd:COG1196  398 LAAQLEELEEAEEALLERLERLEEELEELEEALAELEeeeeeeeealEEAAEEEAELEEEEEALLELLAELLEEAALLEA 477

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 226823220 381 EYNMLLDIKTRLEQEIATYRNLLEGQDAKMAGIGVREV 418
Cdd:COG1196  478 ALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALL 515
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 204-322 9.43e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.16  E-value: 9.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   204 GLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFssQLAGQVNVEMDAAPGVDLTRMLAEMREQYEAIAEKNR 283
Cdd:smart00787 148 GLDENLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEEL--RQLKQLEDELEDCDPTELDRAKEKLKKLLQEIMIKVK 225

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 226823220   284 RDVEawFFSKTEELNKEVASNTEMIQTSKTEITDLRRTL 322
Cdd:smart00787 226 KLEE--LEEELQELESKIEDLTNKKSELNTEIAEAEKKL 262
PRK11281 PRK11281
mechanosensitive channel MscK;
292-408 1.65e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.05  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220  292 SKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLSMKAgLENSLAEVEcryaTQLQQIQGVITGLETQLSEL 371
Cdd:PRK11281   80 EETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLSTLSLRQ-LESRLAQTL----DQLQNAQNDLAEYNSQLVSL 154

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 226823220  372 RCEME-AQNQEYNMLldikTRLeQEIatyRNLLEGQDA 408
Cdd:PRK11281  155 QTQPErAQAALYANS----QRL-QQI---RNLLKGGKV 184
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
97-409 1.90e-140

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 404.69  E-value: 1.90e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   97 NEKVTMQNLNDRLASYLDKVRALEQANTELEVKIRDWYQKQSPAsPDRDYSHYFKTMEEIRDKILAATIDNSRVVLEIDN 176
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGAE-PSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220  177 ARLAADDFRLKYENELTLRQGVEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFSSQLA-GQVNVE 255
Cdd:pfam00038  80 LRLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSdTQVNVE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220  256 MDAAPGVDLTRMLAEMREQYEAIAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLSM 335
Cdd:pfam00038 160 MDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQ 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226823220  336 KAGLENSLAEVECRYATQLQQIQGVITGLETQLSELRCEMEAQNQEYNMLLDIKTRLEQEIATYRNLLEGQDAK 409
Cdd:pfam00038 240 KASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 115-398 1.53e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.83  E-value: 1.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   115 KVRALEQANTELEVKIRDWYQKQSPASPDRDYSHyfKTMEEIRDKILAATIDNSRVVLEIDNARLAADDFRLKYENELTL 194
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELEELEEELEQLR--KELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAE 762

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   195 RQGVEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFSsqlagQVNVEMDaapgvDLTRMLAEMREQ 274
Cdd:TIGR02168  763 IEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELT-----LLNEEAA-----NLRERLESLERR 832

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   275 YEAIAEKNRRDVEAWffsktEELNKEVASNTEmiqtsktEITDLRRTLQGLEIELQSQLSMKAGLENSLAEVECRYATQL 354
Cdd:TIGR02168  833 IAATERRLEDLEEQI-----EELSEDIESLAA-------EIEELEELIEELESELEALLNERASLEEALALLRSELEELS 900

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 226823220   355 QQIQgvitGLETQLSELRCEMEAQNQEYNMLLDIKTRLEQEIAT 398
Cdd:TIGR02168  901 EELR----ELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 151-418 9.90e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.01  E-value: 9.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 151 KTMEEIRDKILAATIDNSRVVLEIDNARLAADDFRLKYENELTLRQGVEADINGLRRVLDELTLARTDLEMQIEQLNEEL 230
Cdd:COG1196  246 AELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEEL 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 231 AYLKKNHEEEMKEFSSQLAGQVNVEMDAApgvDLTRMLAEMREQYEAIAEKNRRDVEAWffsktEELNKEVASNTEMIQT 310
Cdd:COG1196  326 AELEEELEELEEELEELEEELEEAEEELE---EAEAELAEAEEALLEAEAELAEAEEEL-----EELAEELLEALRAAAE 397

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 311 SKTEITDLRRTLQGLEIELQSQLSMKAGLENSLAEVE----------CRYATQLQQIQGVITGLETQLSELRCEMEAQNQ 380
Cdd:COG1196  398 LAAQLEELEEAEEALLERLERLEEELEELEEALAELEeeeeeeeealEEAAEEEAELEEEEEALLELLAELLEEAALLEA 477

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 226823220 381 EYNMLLDIKTRLEQEIATYRNLLEGQDAKMAGIGVREV 418
Cdd:COG1196  478 ALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALL 515
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 170-406 1.06e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.06  E-value: 1.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   170 VVLEIDNARLAADDFRL-KYENELTLRQGVeadINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFSS-- 246
Cdd:TIGR02169  625 VVEDIEAARRLMGKYRMvTLEGELFEKSGA---MTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRie 701

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   247 QLAGQVNVEMDaapgvDLTRMLAEMREQYEAIAEKNRRDVEawffskteelnkEVASNTEMIQTSKTEITDLRRTLQGLE 326
Cdd:TIGR02169  702 NRLDELSQELS-----DASRKIGEIEKEIEQLEQEEEKLKE------------RLEELEEDLSSLEQEIENVKSELKELE 764

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   327 IELQSQLSMKAGLENSLAEVECRYA-TQLQQIQGVITGLETQLSELRCEMEAQNQEYNMLLDIKTRLEQEIAT---YRNL 402
Cdd:TIGR02169  765 ARIEELEEDLHKLEEALNDLEARLShSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQElqeQRID 844


                   ....
gi 226823220   403 LEGQ 406
Cdd:TIGR02169  845 LKEQ 848
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 186-420 2.93e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 2.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 186 LKYENELTLRQGVEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLT 265
Cdd:COG1196  232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERR 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 266 RMLAEMREQYEAIAEKNRRDVEAwFFSKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLSMKAGLENSLAE 345
Cdd:COG1196  312 RELEERLEELEEELAELEEELEE-LEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226823220 346 VEcryaTQLQQIQGVITGLETQLSELRCEMEAQNQEYNMLLDIKTRLEQEIATYRNLLEGQDAKMAGIGVREVSL 420
Cdd:COG1196  391 AL----RAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEAL 461
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
205-404 3.30e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.08  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 205 LRRVLDELTLARTDLEMQIEQLNEELAylkkNHEEEMKEFSSQlAGQVNVEMDAApgvDLTRMLAEMREQYEAiAEKNRR 284
Cdd:COG3206  166 LELRREEARKALEFLEEQLPELRKELE----EAEAALEEFRQK-NGLVDLSEEAK---LLLQQLSELESQLAE-ARAELA 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 285 DVEAWFFSKTEELNKEVASNTEMIQTSktEITDLRRTLQGLEIELQSQLS-----------MKAGLENSLAEVECRYATQ 353
Cdd:COG3206  237 EAEARLAALRAQLGSGPDALPELLQSP--VIQQLRAQLAELEAELAELSArytpnhpdviaLRAQIAALRAQLQQEAQRI 314

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 226823220 354 LQQIQGVITGLETQLSELRCEMEAQNQEYNMLLDIK---TRLEQEIATYRNLLE 404
Cdd:COG3206  315 LASLEAELEALQAREASLQAQLAQLEARLAELPELEaelRRLEREVEVARELYE 368
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 179-419 5.76e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 5.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 179 LAADDFRLKYENELtlrQGVEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKK---NHEEEMKEFSSQLAgQVNVE 255
Cdd:COG4942   16 AAQADAAAEAEAEL---EQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARrirALEQELAALEAELA-ELEKE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 256 MDAapgvdLTRMLAEMREQYE----AIAEKNRRDVEAWFFSKTE--ELNKEVASNTEMIQTSKTEITDLRRTLQGLEIEL 329
Cdd:COG4942   92 IAE-----LRAELEAQKEELAellrALYRLGRQPPLALLLSPEDflDAVRRLQYLKYLAPARREQAEELRADLAELAALR 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 330 QSQLSMKAGLENSLAEVEcryaTQLQQIQGVITGLETQLSELRCEMEAQNQEYnmlldikTRLEQEIATYRNLLEGQDAK 409
Cdd:COG4942  167 AELEAERAELEALLAELE----EERAALEALKAERQKLLARLEKELAELAAEL-------AELQQEAEELEALIARLEAE 235

                        250
                 ....*....|
gi 226823220 410 MAGIGVREVS 419
Cdd:COG4942  236 AAAAAERTPA 245
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 198-420 6.87e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 6.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   198 VEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRMLAEMREQYEA 277
Cdd:TIGR02168  682 LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEA 761

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   278 IAEKNRRDVEAWFF------SKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLSMKAGLENSLAEVECRY- 350
Cdd:TIGR02168  762 EIEELEERLEEAEEelaeaeAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLe 841

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   351 ------------------------------ATQLQQIQGVITGLETQLSELRCEMEAQNQEYNMLLDIKTRLEQEIATYR 400
Cdd:TIGR02168  842 dleeqieelsedieslaaeieeleelieelESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELR 921

                          250       260
                   ....*....|....*....|
gi 226823220   401 NLLEGQDAKMAGIGVREVSL 420
Cdd:TIGR02168  922 EKLAQLELRLEGLEVRIDNL 941
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 204-322 9.43e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.16  E-value: 9.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   204 GLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFssQLAGQVNVEMDAAPGVDLTRMLAEMREQYEAIAEKNR 283
Cdd:smart00787 148 GLDENLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEEL--RQLKQLEDELEDCDPTELDRAKEKLKKLLQEIMIKVK 225

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 226823220   284 RDVEawFFSKTEELNKEVASNTEMIQTSKTEITDLRRTL 322
Cdd:smart00787 226 KLEE--LEEELQELESKIEDLTNKKSELNTEIAEAEKKL 262
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 219-394 1.46e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 40.88  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220  219 LEMQIEQLNEELAYLKKNHEEEMKEFSSQL-AGQVNVEMDAAPGVDLTRMLAEMREQYEAIAEKNRRDVE---------A 288
Cdd:pfam05557   7 SKARLSQLQNEKKQMELEHKRARIELEKKAsALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAElnrlkkkylE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220  289 WFFSKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLSMKAGLENSLAEVECRYA------TQLQQIQGVIT 362
Cdd:pfam05557  87 ALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASeaeqlrQNLEKQQSSLA 166

                         170       180       190
                  ....*....|....*....|....*....|..
gi 226823220  363 GLETQLSELRCEMEAQNQEYNMLLDIKTRLEQ 394
Cdd:pfam05557 167 EAEQRIKELEFEIQSQEQDSEIVKNSKSELAR 198
PRK11281 PRK11281
mechanosensitive channel MscK;
292-408 1.65e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.05  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220  292 SKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLSMKAgLENSLAEVEcryaTQLQQIQGVITGLETQLSEL 371
Cdd:PRK11281   80 EETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLSTLSLRQ-LESRLAQTL----DQLQNAQNDLAEYNSQLVSL 154

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 226823220  372 RCEME-AQNQEYNMLldikTRLeQEIatyRNLLEGQDA 408
Cdd:PRK11281  155 QTQPErAQAALYANS----QRL-QQI---RNLLKGGKV 184
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 196-378 2.97e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.14  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 196 QGVEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEE---EMKEFSSQLAgqvnvemdaapgvDLTRMLAEMR 272
Cdd:COG1579   13 QELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDlekEIKRLELEIE-------------EVEARIKKYE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 273 EQYEAIaeKNRRDVEAwffskteeLNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLSMKAGLENSLAEVECRYAT 352
Cdd:COG1579   80 EQLGNV--RNNKEYEA--------LQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDE 149

                        170       180
                 ....*....|....*....|....*.
gi 226823220 353 QLQQIQGVITGLETQLSELRCEMEAQ 378
Cdd:COG1579  150 ELAELEAELEELEAEREELAAKIPPE 175
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 198-412 5.64e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 39.33  E-value: 5.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   198 VEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRM----LAEMRE 273
Cdd:pfam15921  595 LEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTsrneLNSLSE 674

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220   274 QYEAIAEKnrrdveawFFSKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEielqsqlsmkaGLENSLAEVECRYATQ 353
Cdd:pfam15921  675 DYEVLKRN--------FRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSME-----------GSDGHAMKVAMGMQKQ 735

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 226823220   354 LQQIQGVITGLETQLSELRCEMEAQNQEYNMLLDIKTRLEQEIATyrnlLEGQDAKMAG 412
Cdd:pfam15921  736 ITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELST----VATEKNKMAG 790
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
173-394 6.51e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 38.84  E-value: 6.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 173 EIDNARLAADDFRLKyeNELTlrqGVEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFSSQLAGQV 252
Cdd:COG3206  190 ELEEAEAALEEFRQK--NGLV---DLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSPV 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220 253 NVEMDAAPgVDLTRMLAEMREQYeaiAEKNrrdveawffSKTEELNKEVASNTEMIQTSkteitdLRRTLQGLEIELQSQ 332
Cdd:COG3206  265 IQQLRAQL-AELEAELAELSARY---TPNH---------PDVIALRAQIAALRAQLQQE------AQRILASLEAELEAL 325

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226823220 333 LSMKAGLENSLAevecryatQLQQIQGVITGLETQLSELRCEMEAQNQEYNMLLdikTRLEQ 394
Cdd:COG3206  326 QAREASLQAQLA--------QLEARLAELPELEAELRRLEREVEVARELYESLL---QRLEE 376
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 196-381 8.27e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 38.34  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220  196 QGVEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEE-EMKEFSSQLAGQVNVEMDAAPGVDLTRMLAEMREQ 274
Cdd:pfam07888  55 RQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEElEEKYKELSASSEELSEEKDALLAQRAAHEARIREL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823220  275 YEAIAEKNRRDVEAWffSKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLSMKAGLENSLAEVEcryaTQL 354
Cdd:pfam07888 135 EEDIKTLTQRVLERE--TELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRD----TQV 208

                         170       180       190
                  ....*....|....*....|....*....|
gi 226823220  355 QQIQGVITGLETQLSELR---CEMEAQNQE 381
Cdd:pfam07888 209 LQLQDTITTLTQKLTTAHrkeAENEALLEE 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH