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E1 protein, partial [Rubella virus]
List of domain hits
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Name | Accession | Description | Interval | E-value | |||||
Rubella_E1 super family | cl05356 | Rubella membrane glycoprotein E1; Rubella virus (RV), the sole member of the genus Rubivirus ... |
1-246 | 0e+00 | |||||
Rubella membrane glycoprotein E1; Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus. The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58 kDa) and E2 (42-46 kDa). In virus infected cells, RV matures by budding either at the plasma membrane, or at the internal membranes depending on the cell type and enters adjacent uninfected cells by a membrane fusion process in the endosome, directed by E1-E2 heterodimers. The heterodimer formation is crucial for E1 transport out of the endoplasmic reticulum to the Golgi and plasma membrane. In RV E1, a cysteine at position 82 is crucial for the E1-E2 heterodimer formation and cell surface expression of the two proteins. The E1 has been shown to be a type 1 membrane protein, rich in cysteine residues with extensive intramolecular disulfide bonds. The actual alignment was detected with superfamily member pfam05748: Pssm-ID: 283418 Cd Length: 496 Bit Score: 506.20 E-value: 0e+00
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Name | Accession | Description | Interval | E-value | |||||
Rubella_E1 | pfam05748 | Rubella membrane glycoprotein E1; Rubella virus (RV), the sole member of the genus Rubivirus ... |
1-246 | 0e+00 | |||||
Rubella membrane glycoprotein E1; Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus. The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58 kDa) and E2 (42-46 kDa). In virus infected cells, RV matures by budding either at the plasma membrane, or at the internal membranes depending on the cell type and enters adjacent uninfected cells by a membrane fusion process in the endosome, directed by E1-E2 heterodimers. The heterodimer formation is crucial for E1 transport out of the endoplasmic reticulum to the Golgi and plasma membrane. In RV E1, a cysteine at position 82 is crucial for the E1-E2 heterodimer formation and cell surface expression of the two proteins. The E1 has been shown to be a type 1 membrane protein, rich in cysteine residues with extensive intramolecular disulfide bonds. Pssm-ID: 283418 Cd Length: 496 Bit Score: 506.20 E-value: 0e+00
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Name | Accession | Description | Interval | E-value | |||||
Rubella_E1 | pfam05748 | Rubella membrane glycoprotein E1; Rubella virus (RV), the sole member of the genus Rubivirus ... |
1-246 | 0e+00 | |||||
Rubella membrane glycoprotein E1; Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus. The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58 kDa) and E2 (42-46 kDa). In virus infected cells, RV matures by budding either at the plasma membrane, or at the internal membranes depending on the cell type and enters adjacent uninfected cells by a membrane fusion process in the endosome, directed by E1-E2 heterodimers. The heterodimer formation is crucial for E1 transport out of the endoplasmic reticulum to the Golgi and plasma membrane. In RV E1, a cysteine at position 82 is crucial for the E1-E2 heterodimer formation and cell surface expression of the two proteins. The E1 has been shown to be a type 1 membrane protein, rich in cysteine residues with extensive intramolecular disulfide bonds. Pssm-ID: 283418 Cd Length: 496 Bit Score: 506.20 E-value: 0e+00
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