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Conserved domains on  [gi|226442878|ref|NP_998769|]
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ADAMTS-like protein 5 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NTR_like cd03523
NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in ...
 365-466 6.82e-32

NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex.


:

Pssm-ID: 239600  Cd Length: 105  Bit Score: 117.57  E-value: 6.82e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878 365 HYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPL----RAREYVWAPGHCPC-PMLAPHRDYLMAVQRLVSpdgt 439
Cdd:cd03523    2 AFCKSDYVVRAKIKEIKEENDDVKYEVKIIKIYKTGKAKadkaDLRFYYTAPACCPChPILNPGREYLIMGKEEDS---- 77

                         90       100
                 ....*....|....*....|....*...
gi 226442878 440 QDQLLLPHAGYARPWSPA-EDSRIRLTA 466
Cdd:cd03523   78 QGGLVLDPLSFVEPWSPLsLRQDRRLRE 105
ADAMTS_spacer1 super family cl20316
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 205-301 5.81e-28

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


The actual alignment was detected with superfamily member pfam05986:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 107.28  E-value: 5.81e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878  205 GYWNVTLIPEGARHIRVEHR--SRNHLALMGGDGRYVLNGHWVVSP-PGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDL 281
Cdd:pfam05986  13 GYVTFVTIPAGATHIHIVNRkpSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPALEELHAPGPTQEDL 92

                          90       100
                  ....*....|....*....|...
gi 226442878  282 LLQVLLQ---EPNPGIEFEFWLP 301
Cdd:pfam05986  93 EIQVLRQygkGTNPGITYEYFIP 115
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 38-87 1.98e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 58.75  E-value: 1.98e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 226442878    38 WTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCP 87
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqnGGGPCTGEDVETRACNEQPCP 53
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 93-190 2.79e-11

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 60.49  E-value: 2.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878   93 FRDLQCALYNGRPVL---GTQKTYQW---VPFHGAPNQCDLNCLAEGHAFYHSFG-RVLDGTACSP------GAQGVCVA 159
Cdd:pfam19236   5 FMSQQCARTDGQPLRsspGGASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGdSFLDGTRCMPsgpredGTLSLCVL 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 226442878  160 GRCLSAGCDGLLGSGALEDRCGRCGGANDSC 190
Cdd:pfam19236  85 GSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
 
Name Accession Description Interval E-value
NTR_like cd03523
NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in ...
 365-466 6.82e-32

NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex.


Pssm-ID: 239600  Cd Length: 105  Bit Score: 117.57  E-value: 6.82e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878 365 HYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPL----RAREYVWAPGHCPC-PMLAPHRDYLMAVQRLVSpdgt 439
Cdd:cd03523    2 AFCKSDYVVRAKIKEIKEENDDVKYEVKIIKIYKTGKAKadkaDLRFYYTAPACCPChPILNPGREYLIMGKEEDS---- 77

                         90       100
                 ....*....|....*....|....*...
gi 226442878 440 QDQLLLPHAGYARPWSPA-EDSRIRLTA 466
Cdd:cd03523   78 QGGLVLDPLSFVEPWSPLsLRQDRRLRE 105
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 205-301 5.81e-28

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 107.28  E-value: 5.81e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878  205 GYWNVTLIPEGARHIRVEHR--SRNHLALMGGDGRYVLNGHWVVSP-PGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDL 281
Cdd:pfam05986  13 GYVTFVTIPAGATHIHIVNRkpSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPALEELHAPGPTQEDL 92

                          90       100
                  ....*....|....*....|...
gi 226442878  282 LLQVLLQ---EPNPGIEFEFWLP 301
Cdd:pfam05986  93 EIQVLRQygkGTNPGITYEYFIP 115
NTR pfam01759
UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein ...
 365-463 1.54e-19

UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in. Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs). The TIMPs are classified as a separate family in Pfam (pfam00965). This expanded domain family has been named as the NTR module.


Pssm-ID: 396359  Cd Length: 106  Bit Score: 83.55  E-value: 1.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878  365 HYC-GSDFVFQARVLGHHHQAQETRYEVRIQLVYK--NRSPLRAREYVWAP-GHCPCPMLAPHRDYLMAVQrlVSPDGTQ 440
Cdd:pfam01759   2 KACkGSDYVYKVKVLSVEEEGSFDKYTVKVKEVLKegTDKIQRGKVRLFLKrGDCRCPQLRLGKEYLIMGK--VGDLEGR 79

                          90       100
                  ....*....|....*....|...
gi 226442878  441 DQLLLPHAGYARPWSPAEDSRIR 463
Cdd:pfam01759  80 GRYVLDKNSWVEPWPTKWECKLR 102
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 38-87 1.98e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 58.75  E-value: 1.98e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 226442878    38 WTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCP 87
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqnGGGPCTGEDVETRACNEQPCP 53
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 93-190 2.79e-11

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 60.49  E-value: 2.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878   93 FRDLQCALYNGRPVL---GTQKTYQW---VPFHGAPNQCDLNCLAEGHAFYHSFG-RVLDGTACSP------GAQGVCVA 159
Cdd:pfam19236   5 FMSQQCARTDGQPLRsspGGASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGdSFLDGTRCMPsgpredGTLSLCVL 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 226442878  160 GRCLSAGCDGLLGSGALEDRCGRCGGANDSC 190
Cdd:pfam19236  85 GSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP_1 pfam00090
Thrombospondin type 1 domain;
39-86 6.89e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 45.87  E-value: 6.89e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 226442878   39 TPWVSWTRCSSSCGRGVSVRSRRC-LRLPGEEPCWGDSHEYRLCQLPDC 86
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCkSPFPGGEPCTGDDIETQACKMDKC 49
C345C smart00643
Netrin C-terminal Domain;
365-445 3.89e-05

Netrin C-terminal Domain;


Pssm-ID: 214759  Cd Length: 114  Bit Score: 42.74  E-value: 3.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878   365 HYCGS--DFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPL--RAREYVW---APGHCPCPM-LAPHRDYL-MAVQRLVS 435
Cdd:smart00643   3 KACKSdvDYVYKVKVLSVEEEGGFDKYTVKILEVIKSGTDElvRGKNKLRvfiSRASCRCPLlLKLGKSYLiMGKSGDLW 82

                           90
                   ....*....|
gi 226442878   436 PDGTQDQLLL 445
Cdd:smart00643  83 DAKGRGQYVL 92
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 40-92 8.72e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 44.95  E-value: 8.72e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 226442878  40 PWVSWTRCSSSCGRGVSVRSRRCLrlpgEEPCwgDSHEYRLCQLPDCPPGAVP 92
Cdd:PTZ00441 242 PWDEWTPCSVTCGKGTHSRSRPIL----HEGC--TTHMVEECEEEECPVEPEP 288
ACR smart00608
ADAM Cysteine-Rich Domain;
96-164 1.87e-03

ADAM Cysteine-Rich Domain;


Pssm-ID: 214743  Cd Length: 137  Bit Score: 38.50  E-value: 1.87e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226442878    96 LQCALYNGRPVLGTQKTYQWVPFHgapnqcDLNCLAeghAFYHS-----FGRVLDGTACSPGAqgVCVAGRCLS 164
Cdd:smart00608  74 LQCTNVSELPLLGEHATVIYSNIG------GLVCWS---LDYHLgtdpdIGMVKDGTKCGPGK--VCINGQCVD 136
 
Name Accession Description Interval E-value
NTR_like cd03523
NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in ...
 365-466 6.82e-32

NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex.


Pssm-ID: 239600  Cd Length: 105  Bit Score: 117.57  E-value: 6.82e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878 365 HYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPL----RAREYVWAPGHCPC-PMLAPHRDYLMAVQRLVSpdgt 439
Cdd:cd03523    2 AFCKSDYVVRAKIKEIKEENDDVKYEVKIIKIYKTGKAKadkaDLRFYYTAPACCPChPILNPGREYLIMGKEEDS---- 77

                         90       100
                 ....*....|....*....|....*...
gi 226442878 440 QDQLLLPHAGYARPWSPA-EDSRIRLTA 466
Cdd:cd03523   78 QGGLVLDPLSFVEPWSPLsLRQDRRLRE 105
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 205-301 5.81e-28

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 107.28  E-value: 5.81e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878  205 GYWNVTLIPEGARHIRVEHR--SRNHLALMGGDGRYVLNGHWVVSP-PGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDL 281
Cdd:pfam05986  13 GYVTFVTIPAGATHIHIVNRkpSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPALEELHAPGPTQEDL 92

                          90       100
                  ....*....|....*....|...
gi 226442878  282 LLQVLLQ---EPNPGIEFEFWLP 301
Cdd:pfam05986  93 EIQVLRQygkGTNPGITYEYFIP 115
NTR pfam01759
UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein ...
 365-463 1.54e-19

UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in. Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs). The TIMPs are classified as a separate family in Pfam (pfam00965). This expanded domain family has been named as the NTR module.


Pssm-ID: 396359  Cd Length: 106  Bit Score: 83.55  E-value: 1.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878  365 HYC-GSDFVFQARVLGHHHQAQETRYEVRIQLVYK--NRSPLRAREYVWAP-GHCPCPMLAPHRDYLMAVQrlVSPDGTQ 440
Cdd:pfam01759   2 KACkGSDYVYKVKVLSVEEEGSFDKYTVKVKEVLKegTDKIQRGKVRLFLKrGDCRCPQLRLGKEYLIMGK--VGDLEGR 79

                          90       100
                  ....*....|....*....|...
gi 226442878  441 DQLLLPHAGYARPWSPAEDSRIR 463
Cdd:pfam01759  80 GRYVLDKNSWVEPWPTKWECKLR 102
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 38-87 1.98e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 58.75  E-value: 1.98e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 226442878    38 WTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCP 87
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqnGGGPCTGEDVETRACNEQPCP 53
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 93-190 2.79e-11

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 60.49  E-value: 2.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878   93 FRDLQCALYNGRPVL---GTQKTYQW---VPFHGAPNQCDLNCLAEGHAFYHSFG-RVLDGTACSP------GAQGVCVA 159
Cdd:pfam19236   5 FMSQQCARTDGQPLRsspGGASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGdSFLDGTRCMPsgpredGTLSLCVL 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 226442878  160 GRCLSAGCDGLLGSGALEDRCGRCGGANDSC 190
Cdd:pfam19236  85 GSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
NTR_netrin-1_like cd03579
NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called ...
 363-468 2.62e-09

NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural development. These proteins may be chemoattractive to some neurons and chemorepellant for others. In the case of netrin-1, attraction and repulsion responses are mediated by the DCC and UNC-5 receptor families. The biological activities of C. elegans UNC-6, which may either attract or repel migrating cells or axons, are mediated by its different domains. The C-terminal NTR domain of UNC-6 has been shown to inhibit axon branching activity.


Pssm-ID: 239634  Cd Length: 115  Bit Score: 54.94  E-value: 2.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878 363 LLHYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYK-NRSPLRARE-YVWAPGH---CPCPMLAPHRDYLMAVQrlVSPD 437
Cdd:cd03579    1 LKKYCKKDYAVQAQVLSRETAGEWAKFTVNVQTVYKrGTSRLRRGDqPLWVPRKdlaCKCPKLKVGKSYLLLGK--DEDS 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 226442878 438 GTQDQLLLPHAGYARPWSPAEDSRIRLTARR 468
Cdd:cd03579   79 PERGGLILDKRSLVIEWRDEWARRLRRFQRR 109
TSP_1 pfam00090
Thrombospondin type 1 domain;
39-86 6.89e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 45.87  E-value: 6.89e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 226442878   39 TPWVSWTRCSSSCGRGVSVRSRRC-LRLPGEEPCWGDSHEYRLCQLPDC 86
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCkSPFPGGEPCTGDDIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 39-86 1.15e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.35  E-value: 1.15e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 226442878   39 TPWVSWTRCSSSCGRGVSVRSRRCLRLP--GEEPCwGDSHEYRLCQLPDC 86
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRTVIVEPqnGGRPC-PELLERRPCNLPPC 52
C345C smart00643
Netrin C-terminal Domain;
365-445 3.89e-05

Netrin C-terminal Domain;


Pssm-ID: 214759  Cd Length: 114  Bit Score: 42.74  E-value: 3.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878   365 HYCGS--DFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPL--RAREYVW---APGHCPCPM-LAPHRDYL-MAVQRLVS 435
Cdd:smart00643   3 KACKSdvDYVYKVKVLSVEEEGGFDKYTVKILEVIKSGTDElvRGKNKLRvfiSRASCRCPLlLKLGKSYLiMGKSGDLW 82

                           90
                   ....*....|
gi 226442878   436 PDGTQDQLLL 445
Cdd:smart00643  83 DAKGRGQYVL 92
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 40-92 8.72e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 44.95  E-value: 8.72e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 226442878  40 PWVSWTRCSSSCGRGVSVRSRRCLrlpgEEPCwgDSHEYRLCQLPDCPPGAVP 92
Cdd:PTZ00441 242 PWDEWTPCSVTCGKGTHSRSRPIL----HEGC--TTHMVEECEEEECPVEPEP 288
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 38-88 1.31e-03

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 40.70  E-value: 1.31e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 226442878  38 WTPWVSWTRCSSSCGR--GVSVRSRRCLRLPGEepCW-GDSHEYRLCQLPdCPP 88
Cdd:PTZ00087 233 YTEWGEWSNCSMECDHpdNVQIRERKCAHPSGD--CFkGDLKETRPCQVP-LPP 283
ACR smart00608
ADAM Cysteine-Rich Domain;
96-164 1.87e-03

ADAM Cysteine-Rich Domain;


Pssm-ID: 214743  Cd Length: 137  Bit Score: 38.50  E-value: 1.87e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226442878    96 LQCALYNGRPVLGTQKTYQWVPFHgapnqcDLNCLAeghAFYHS-----FGRVLDGTACSPGAqgVCVAGRCLS 164
Cdd:smart00608  74 LQCTNVSELPLLGEHATVIYSNIG------GLVCWS---LDYHLgtdpdIGMVKDGTKCGPGK--VCINGQCVD 136
NTR_TIMP_like cd03577
NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential ...
 365-398 3.45e-03

NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by non-covalently binding their active zinc-binding sites. This group contains domains similar to the TIMP NTR domain, which binds MMPs. Members of this group may or may not function as MMP inhibitors.


Pssm-ID: 239632  Cd Length: 116  Bit Score: 37.34  E-value: 3.45e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 226442878 365 HYCGSDFVFQARVLGHHHQAQ--ETRYEVRIQLVYK 398
Cdd:cd03577   11 KYCQADFVIKVKVLKKKLDGAglNIRYTIEIKKVYK 46
NTR_Sfrp3_like cd03581
NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily; composed of proteins ...
 371-454 7.30e-03

NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily; composed of proteins similar to human Sfrp3 and Sfrp4. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse functions and are thought to work in Wnt signaling indirectly, as modulators or antagonists by binding Wnt ligands, and directly, via the Wnt receptor, Frizzled. They participate in regulating the patterning along the anteroposterior axis in vertebrates. Human Sfrp3 may suppress the growth and invasiveness of androgen-independent prostate cancer cells.


Pssm-ID: 239636  Cd Length: 111  Bit Score: 36.29  E-value: 7.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442878 371 FVFQARVLGHHHQAQETRYEVRIQLVYKNRSPLRAREYV--WAPGHCPCPMLAPHRDYL-MAVQrlvspDGTQDQLLLPH 447
Cdd:cd03581   10 YVIRAKVKEVKRGCHEVTAVVEVKEILKSSLVNIPRDTVtlYTNSGCLCPPLTPNEEYIiMGYE-----DEERSRLLLVE 84


                 ....*..
gi 226442878 448 AGYARPW 454
Cdd:cd03581   85 GSLAEKW 91
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 41-86 7.88e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 34.74  E-value: 7.88e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 226442878   41 WV--SWTRCSSSCGRGVSVRSRRCLRLPGEEPcWGDS--------HEYRLCQLPDC 86
Cdd:pfam19030   1 WVagPWGECSVTCGGGVQTRLVQCVQKGGGSI-VPDSecsaqkkpPETQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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