NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|226438309]
View 

Chain A, SspH2 (Leucine-rich repeat protein)

Protein Classification

NEL-type E3 ubiquitin ligase domain-containing protein( domain architecture ID 1008379)

NEL-type E3 ubiquitin ligase domain-containing protein similar to Salmonella enterica E3 ubiquitin-protein ligase SspH1, an E3 ubiquitin-protein ligase that interferes with the host's ubiquitination pathway and targets host proteins for proteasomal degradation

CATH:  3.80.10.10
Gene Ontology:  GO:0004842
SCOP:  4003209

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK15387 super family cl33133
type III secretion system effector E3 ubiquitin transferase SspH2;
1-622 0e+00

type III secretion system effector E3 ubiquitin transferase SspH2;


The actual alignment was detected with superfamily member PRK15387:

Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 1228.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309   1 GPVDPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALP 80
Cdd:PRK15387 162 APQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALP 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  81 PELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALP 160
Cdd:PRK15387 242 PELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALP 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 161 SELCKLWAYNNQLTSLPMLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLP 240
Cdd:PRK15387 322 SELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLP 401

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 241 SELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIRF 320
Cdd:PRK15387 402 SELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIRF 481

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 321 DMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLAE 400
Cdd:PRK15387 482 DMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLAE 561

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 401 DEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVDE 480
Cdd:PRK15387 562 DEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVDE 641

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 481 IEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALREK 560
Cdd:PRK15387 642 IEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALREK 721

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226438309 561 QISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNV 622
Cdd:PRK15387 722 QISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNV 783
 
Name Accession Description Interval E-value
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
1-622 0e+00

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 1228.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309   1 GPVDPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALP 80
Cdd:PRK15387 162 APQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALP 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  81 PELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALP 160
Cdd:PRK15387 242 PELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALP 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 161 SELCKLWAYNNQLTSLPMLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLP 240
Cdd:PRK15387 322 SELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLP 401

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 241 SELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIRF 320
Cdd:PRK15387 402 SELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIRF 481

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 321 DMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLAE 400
Cdd:PRK15387 482 DMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLAE 561

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 401 DEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVDE 480
Cdd:PRK15387 562 DEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVDE 641

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 481 IEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALREK 560
Cdd:PRK15387 642 IEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALREK 721

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226438309 561 QISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNV 622
Cdd:PRK15387 722 QISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNV 783
NEL pfam14496
C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at ...
 341-553 1.07e-85

C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred.


Pssm-ID: 433992 [Multi-domain]  Cd Length: 216  Bit Score: 266.51  E-value: 1.07e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  341 WLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDA-GFKAQISSWLAQLAEDEALRANTFAMATEATSSC 419
Cdd:pfam14496   1 WLQACAELRPERLAAWRALEAEEGAAAFFRFLARLRETASFRNDAeALRERVWAVLQAAAHDPALRAQLFAIAGDAPASC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  420 EDRVTFFLHQMKNVQLVHNAEKGQYDND-LAALVATGREMFRLGKLEQIAREKVRTLALVDEIEVWLAYQNKLKKSLGLT 498
Cdd:pfam14496  81 EDRVTLTFNNLELAVLVHQAEDGAYDGNrLAALLSLGRRLFRLDQLEDIAREKVARRRRVDEIEVRLAYRVRLRESLDLP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 226438309  499 SVTSEMRFFDVSGVTVTDLQDAELQVKAAE-KSEFREWILQWGPLHRVLERKAPER 553
Cdd:pfam14496 161 NQPPEMRFFNISGVTDADLDRAEARVRAAEtPEAFARWLAQRPFWRQYLERIHPER 216
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-356 5.00e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 5.00e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  61 AHITTLVIPDNNLTSLPAL---PPELRTLEVSGNQLTSLPvlppgllelsifsNPLTHLPALPSglckLWIFGNQLTSLP 137
Cdd:COG4886  113 TNLESLDLSGNQLTDLPEElanLTNLKELDLSNNQLTDLP-------------EPLGNLTNLKS----LDLSNNQLTDLP 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 138 V----LPpGLQELSVSDNQLASLPALPSELC---KLWAYNNQLTSLPM----LPSgLQELSVSDNQLASLPTLP--SELY 204
Cdd:COG4886  176 EelgnLT-NLKELDLSNNQITDLPEPLGNLTnleELDLSGNQLTDLPEplanLTN-LETLDLSNNQLTDLPELGnlTNLE 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 205 KLWAYNNRLTSLPALP--SGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIH 282
Cdd:COG4886  254 ELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226438309 283 LSSETTVNLEGNPLSERTLQALREITSAPGYS--GPIIRFDMAGASAPRETRALHLAAADWLVPAREGEPAPADRW 356
Cdd:COG4886  334 LVTLTTLALSLSLLALLTLLLLLNLLSLLLTLllTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 123-297 2.49e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 2.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 123 LCKLWIFGNQLTSLPVLP--PGLQELSVSDNQLASLP---ALPSeLCKLWAYNNQLTSLPML--PSGLQELSVSDNQLAS 195
Cdd:cd21340   26 LKVLYLYDNKITKIENLEflTNLTHLYLQNNQIEKIEnleNLVN-LKKLYLGGNRISVVEGLenLTNLEELHIENQRLPP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 196 lptlpselyklwayNNRLT----SLPALPSGLKELIVSGNRLTSLPVLP--SELKELMVSGNRLTSLpmlpsgllslsvy 269
Cdd:cd21340  105 --------------GEKLTfdprSLAALSNSLRVLNISGNNIDSLEPLAplRNLEQLDASNNQISDL------------- 157

                        170       180
                 ....*....|....*....|....*...
gi 226438309 270 rNQLTRLPESLIHLsseTTVNLEGNPLS 297
Cdd:cd21340  158 -EELLDLLSSWPSL---RELDLTGNPVC 181
 
Name Accession Description Interval E-value
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
1-622 0e+00

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 1228.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309   1 GPVDPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALP 80
Cdd:PRK15387 162 APQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALP 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  81 PELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALP 160
Cdd:PRK15387 242 PELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALP 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 161 SELCKLWAYNNQLTSLPMLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLP 240
Cdd:PRK15387 322 SELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLP 401

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 241 SELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIRF 320
Cdd:PRK15387 402 SELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIRF 481

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 321 DMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLAE 400
Cdd:PRK15387 482 DMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLAE 561

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 401 DEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVDE 480
Cdd:PRK15387 562 DEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVDE 641

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 481 IEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALREK 560
Cdd:PRK15387 642 IEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALREK 721

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226438309 561 QISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNV 622
Cdd:PRK15387 722 QISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNV 783
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
1-605 0e+00

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 541.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309   1 GPVDPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPA-L 79
Cdd:PRK15370 139 GSKDAVNYELIWSEWVKEAPAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPEnL 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  80 PPELRTLEVSGNQLTSLP-VLPPGLLELSIFSNPLTHLPA-LPSGLCKLWIFGNQLTSLP-VLPPGLQELSVSDNQLASL 156
Cdd:PRK15370 219 QGNIKTLYANSNQLTSIPaTLPDTIQEMELSINRITELPErLPSALQSLDLFHNKISCLPeNLPEELRYLSVYDNSIRTL 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 157 PA-LPSELCKLWAYNNQLTSLP-MLPSGLQELSVSDNQLASLPTlpselyklwaynnrltslpALPSGLKELIVSGNRLT 234
Cdd:PRK15370 299 PAhLPSGITHLNVQSNSLTALPeTLPPGLKTLEAGENALTSLPA-------------------SLPPELQVLDVSKNQIT 359

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 235 SLP-VLPSELKELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRLPESLIHLSSE----TTVNLEGNPLSERTLQALREIT 308
Cdd:PRK15370 360 VLPeTLPPTITTLDVSRNALTNLPEnLPAALQIMQASRNNLVRLPESLPHFRGEgpqpTRIIVEYNPFSERTIQNMQRLM 439

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 309 SAPGYSGPIIRFDMAGASAPRETRALHLAAADWLVPAREGEpapADRWHMFGQEDNADAFSLFLDRLSETENfIKDAGFK 388
Cdd:PRK15370 440 SSVGYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTNLEEED---VNQWRAFETEVNAAAFSMFLDRLSDTQN-TRHPDFK 515

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 389 AQISSWLAQLAEDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIA 468
Cdd:PRK15370 516 EQVSAWLMRLAEDSALRETAFIIAMDATISCEDRVTLAYHQMQEATLVHDAERGAFDSHLAELIMAGREIFRLEQIESLA 595

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 469 REKVRTLALVDEIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLER 548
Cdd:PRK15370 596 REKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSGITESDLDEAEIRIKIAENRDFHKWFALWGPWHKVLER 675

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 226438309 549 KAPERVNALREKQIsDYEET--YRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFL 605
Cdd:PRK15370 676 IAPEEWREMMAKRA-ECIETdeYQSRVNAELEALGIAGDPDAERMAGMRIMEEINQTLF 733
NEL pfam14496
C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at ...
 341-553 1.07e-85

C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred.


Pssm-ID: 433992 [Multi-domain]  Cd Length: 216  Bit Score: 266.51  E-value: 1.07e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  341 WLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDA-GFKAQISSWLAQLAEDEALRANTFAMATEATSSC 419
Cdd:pfam14496   1 WLQACAELRPERLAAWRALEAEEGAAAFFRFLARLRETASFRNDAeALRERVWAVLQAAAHDPALRAQLFAIAGDAPASC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  420 EDRVTFFLHQMKNVQLVHNAEKGQYDND-LAALVATGREMFRLGKLEQIAREKVRTLALVDEIEVWLAYQNKLKKSLGLT 498
Cdd:pfam14496  81 EDRVTLTFNNLELAVLVHQAEDGAYDGNrLAALLSLGRRLFRLDQLEDIAREKVARRRRVDEIEVRLAYRVRLRESLDLP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 226438309  499 SVTSEMRFFDVSGVTVTDLQDAELQVKAAE-KSEFREWILQWGPLHRVLERKAPER 553
Cdd:pfam14496 161 NQPPEMRFFNISGVTDADLDRAEARVRAAEtPEAFARWLAQRPFWRQYLERIHPER 216
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-356 5.00e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 5.00e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  61 AHITTLVIPDNNLTSLPAL---PPELRTLEVSGNQLTSLPvlppgllelsifsNPLTHLPALPSglckLWIFGNQLTSLP 137
Cdd:COG4886  113 TNLESLDLSGNQLTDLPEElanLTNLKELDLSNNQLTDLP-------------EPLGNLTNLKS----LDLSNNQLTDLP 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 138 V----LPpGLQELSVSDNQLASLPALPSELC---KLWAYNNQLTSLPM----LPSgLQELSVSDNQLASLPTLP--SELY 204
Cdd:COG4886  176 EelgnLT-NLKELDLSNNQITDLPEPLGNLTnleELDLSGNQLTDLPEplanLTN-LETLDLSNNQLTDLPELGnlTNLE 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 205 KLWAYNNRLTSLPALP--SGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIH 282
Cdd:COG4886  254 ELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226438309 283 LSSETTVNLEGNPLSERTLQALREITSAPGYS--GPIIRFDMAGASAPRETRALHLAAADWLVPAREGEPAPADRW 356
Cdd:COG4886  334 LVTLTTLALSLSLLALLTLLLLLNLLSLLLTLllTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-308 7.58e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 7.58e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  44 VLNVGESGLTTLPDCLPA--HITTLVIPDNNLTSLPA-LP--PELRTLEVSGNQLTSLPV----LPpGLLELSIFSNPLT 114
Cdd:COG4886  117 SLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEpLGnlTNLKSLDLSNNQLTDLPEelgnLT-NLKELDLSNNQIT 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 115 HLPALPSGLC---KLWIFGNQLTSLPV-LP--PGLQELSVSDNQLASLPALP--SELCKLWAYNNQLTSLPMLP--SGLQ 184
Cdd:COG4886  196 DLPEPLGNLTnleELDLSGNQLTDLPEpLAnlTNLETLDLSNNQLTDLPELGnlTNLEELDLSNNQLTDLPPLAnlTNLK 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 185 ELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLL 264
Cdd:COG4886  276 TLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLL 355

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 226438309 265 SLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREIT 308
Cdd:COG4886  356 LNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-298 8.84e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 8.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  46 NVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCK 125
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 126 LWIFGNQLTSLPVLPPGLQELSVSDNQ-LASLPALPSelckLWAYNNQLTSLPMLPSG---LQELSVSDNQLASLPT--- 198
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEeLSNLTNLES----LDLSGNQLTDLPEELANltnLKELDLSNNQLTDLPEplg 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 199 -LPSeLYKLWAYNNRLTSLPA----LPSgLKELIVSGNRLTSLPvlpSELKELmvsgnrltslpmlpSGLLSLSVYRNQL 273
Cdd:COG4886  157 nLTN-LKSLDLSNNQLTDLPEelgnLTN-LKELDLSNNQITDLP---EPLGNL--------------TNLEELDLSGNQL 217

                        250       260
                 ....*....|....*....|....*
gi 226438309 274 TRLPESLIHLSSETTVNLEGNPLSE 298
Cdd:COG4886  218 TDLPEPLANLTNLETLDLSNNQLTD 242
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 123-297 2.49e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 2.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 123 LCKLWIFGNQLTSLPVLP--PGLQELSVSDNQLASLP---ALPSeLCKLWAYNNQLTSLPML--PSGLQELSVSDNQLAS 195
Cdd:cd21340   26 LKVLYLYDNKITKIENLEflTNLTHLYLQNNQIEKIEnleNLVN-LKKLYLGGNRISVVEGLenLTNLEELHIENQRLPP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 196 lptlpselyklwayNNRLT----SLPALPSGLKELIVSGNRLTSLPVLP--SELKELMVSGNRLTSLpmlpsgllslsvy 269
Cdd:cd21340  105 --------------GEKLTfdprSLAALSNSLRVLNISGNNIDSLEPLAplRNLEQLDASNNQISDL------------- 157

                        170       180
                 ....*....|....*....|....*...
gi 226438309 270 rNQLTRLPESLIHLsseTTVNLEGNPLS 297
Cdd:cd21340  158 -EELLDLLSSWPSL---RELDLTGNPVC 181
PRK15386 PRK15386
type III secretion effector GogB;
186-268 1.19e-07

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 54.49  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 186 LSVSDNQLASLPTLPSELYKLWAYN-NRLTSLP-ALPSGLKELIVSgnRLTSLPVLPSELKELMVSGNRLTSLPMLPSGL 263
Cdd:PRK15386  57 LYIKDCDIESLPVLPNELTEITIENcNNLTTLPgSIPEGLEKLTVC--HCPEISGLPESVRSLEIKGSATDSIKNVPNGL 134


                 ....*
gi 226438309 264 LSLSV 268
Cdd:PRK15386 135 TSLSI 139
PRK15386 PRK15386
type III secretion effector GogB;
66-192 6.03e-07

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 52.18  E-value: 6.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  66 LVIPDNNLTSLPALPPELRTLEVSG-NQLTSLP-VLPPGLLELSIFSNPltHLPALPSGLCKLWIFGNQLTSLPVLPPGL 143
Cdd:PRK15386  57 LYIKDCDIESLPVLPNELTEITIENcNNLTTLPgSIPEGLEKLTVCHCP--EISGLPESVRSLEIKGSATDSIKNVPNGL 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 226438309 144 QELSVSD----NQLASLPALPSELCKLWAYNNQLTSLPM-LPSGLQELSVSDNQ 192
Cdd:PRK15386 135 TSLSINSynpeNQARIDNLISPSLKTLSLTGCSNIILPEkLPESLQSITLHIEQ 188
PRK15386 PRK15386
type III secretion effector GogB;
52-152 4.35e-05

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 46.40  E-value: 4.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  52 LTTLPDCLPAHITTLVIpdNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELSIFS-NPLTHL---PALPSGLCKLW 127
Cdd:PRK15386  85 LTTLPGSIPEGLEKLTV--CHCPEISGLPESVRSLEIKGSATDSIKNVPNGLTSLSINSyNPENQAridNLISPSLKTLS 162

                         90       100
                 ....*....|....*....|....*.
gi 226438309 128 IFGNQLTSLPV-LPPGLQELSVSDNQ 152
Cdd:PRK15386 163 LTGCSNIILPEkLPESLQSITLHIEQ 188
LRR_8 pfam13855
Leucine rich repeat;
241-296 1.66e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.66e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226438309  241 SELKELMVSGNRLTSLPM-----LPSgLLSLSVYRNQLTRL-PESLIHLSSETTVNLEGNPL 296
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgafkgLSN-LKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15386 PRK15386
type III secretion effector GogB;
86-308 1.89e-04

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 44.09  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  86 LEVSGNQLTSLPVLPPGLLELSIFSnplthlpalpsglCklwifgNQLTSLP-VLPPGLQELSVSdnQLASLPALPSELC 164
Cdd:PRK15386  57 LYIKDCDIESLPVLPNELTEITIEN-------------C------NNLTTLPgSIPEGLEKLTVC--HCPEISGLPESVR 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 165 KLWAYNNQLTSLPMLPSGLQELSVSDnqlaslptlpselyklwaYNNrltslpalpsglkeliVSGNRLTSLpvLPSELK 244
Cdd:PRK15386 116 SLEIKGSATDSIKNVPNGLTSLSINS------------------YNP----------------ENQARIDNL--ISPSLK 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226438309 245 ELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREIT 308
Cdd:PRK15386 160 TLSLTGCSNIILPEkLPESLQSITLHIEQKTTWNISFEGFPDGLDIDLQNSVLLSPDVFKDKNIT 224
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 140-311 2.13e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 2.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 140 PPGLQELSVSDNQLASLP----ALPSELCKLWaynnqltslpmlpsGLQELSVSDNQL--ASLPTLPS--------ELYK 205
Cdd:cd00116   50 QPSLKELCLSLNETGRIPrglqSLLQGLTKGC--------------GLQELDLSDNALgpDGCGVLESllrssslqELKL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 206 LwayNNRL---------TSLPALPSGLKELIVSGNRLTS---------LPVLPSeLKELMVSGNRLT---------SLPM 258
Cdd:cd00116  116 N---NNGLgdrglrllaKGLKDLPPALEKLVLGRNRLEGascealakaLRANRD-LKELNLANNGIGdagiralaeGLKA 191

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 226438309 259 LpSGLLSLSVYRNQLTR-----LPESLIHLSSETTVNLEGNPLSERTLQALREITSAP 311
Cdd:cd00116  192 N-CNLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAGAAALASALLSP 248
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-221 2.19e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.15  E-value: 2.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  45 LNVGESGLTTLPD--CLPaHITTLVIPDNNLTSLPALP--PELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALP 120
Cdd:COG4886  233 LDLSNNQLTDLPElgNLT-NLEELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 121 SGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPMLPSGLQELSVSDNQLASLPTLP 200
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391

                        170       180
                 ....*....|....*....|.
gi 226438309 201 SELYKLWAYNNRLTSLPALPS 221
Cdd:COG4886  392 LLLTTTAGVLLLTLALLDAVN 412
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 99-295 2.29e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.01  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309   99 LPPGLLELSIFSNPLTHLPA--LPSGLCKLWIFGNQLTSL--PVLP-PGLQELSV--SDNqLASLP--ALPSELCKLwaY 169
Cdd:PLN03210  587 LPPKLRLLRWDKYPLRCMPSnfRPENLVKLQMQGSKLEKLwdGVHSlTGLRNIDLrgSKN-LKEIPdlSMATNLETL--K 663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  170 NNQLTSLPMLPSGLQELsvsdNQLAS--------LPTLPS--ELYKLWAYN----NRLTSLPALPSGLKELIVSGnrlTS 235
Cdd:PLN03210  664 LSDCSSLVELPSSIQYL----NKLEDldmsrcenLEILPTgiNLKSLYRLNlsgcSRLKSFPDISTNISWLDLDE---TA 736

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309  236 LPVLPSELK-----EL----MVSGNR------LTSL-PMLPSGLLSLSVYRNQ-LTRLPES------LIHLSSETTVNLE 292
Cdd:PLN03210  737 IEEFPSNLRlenldELilceMKSEKLwervqpLTPLmTMLSPSLTRLFLSDIPsLVELPSSiqnlhkLEHLEIENCINLE 816


                  ...
gi 226438309  293 GNP 295
Cdd:PLN03210  817 TLP 819
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 116-234 9.30e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.49  E-value: 9.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 116 LPALPSGLCKLWIFGNQLTSLP------VLP--PGLQELSVSDNQL------ASLPALP--SELCKLWAYNNQLTS---- 175
Cdd:cd00116  132 LKDLPPALEKLVLGRNRLEGAScealakALRanRDLKELNLANNGIgdagirALAEGLKanCNLEVLDLNNNGLTDegas 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226438309 176 -----LPMLPSgLQELSVSDNQLAS---------LPTLPSELYKLWAYNNRLT---------SLPALPSgLKELIVSGNR 232
Cdd:cd00116  212 alaetLASLKS-LEVLNLGDNNLTDagaaalasaLLSPNISLLTLSLSCNDITddgakdlaeVLAEKES-LLELDLRGNK 289


                 ..
gi 226438309 233 LT 234
Cdd:cd00116  290 FG 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH