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Conserved domains on  [gi|225690558|ref|NP_149050|]
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putative keratin-associated protein 4-X [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 42-155 2.89e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 68.66  E-value: 2.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690558   42 PSCCVSSCCRPQCCQSVCCQPTCCRPTCCETTCCHPRCCISSCCRPSCcmSSCCKPQCCQSVCCQPTCCRPSCCRPCCCL 121
Cdd:pfam01500  12 PTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQTGCGGIGYGQ 89

                          90       100       110
                  ....*....|....*....|....*....|....
gi 225690558  122 RPVCGRVSCHTTCYRPTCVISTCPRPLCCASSCC 155
Cdd:pfam01500  90 EGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCT 123
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 42-155 2.89e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 68.66  E-value: 2.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690558   42 PSCCVSSCCRPQCCQSVCCQPTCCRPTCCETTCCHPRCCISSCCRPSCcmSSCCKPQCCQSVCCQPTCCRPSCCRPCCCL 121
Cdd:pfam01500  12 PTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQTGCGGIGYGQ 89

                          90       100       110
                  ....*....|....*....|....*....|....
gi 225690558  122 RPVCGRVSCHTTCYRPTCVISTCPRPLCCASSCC 155
Cdd:pfam01500  90 EGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCT 123
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
24-108 3.51e-06

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 45.31  E-value: 3.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690558  24 CCRPSCCQTTCCRTTCYRPSCCvssCCRPQCCqsvCCQPTCCRPTCCETTCCHPRCCISSCCRPSCCMssCCkpQCCQSV 103
Cdd:COG3901  606 FRRLCLLGLALAAAALARRRLW---RRRRREC---CCGCCCCCCKCCCIVIIIDGIIIINECCCCCCL--CC--RRCQDD 675


                 ....*
gi 225690558 104 CCQPT 108
Cdd:COG3901  676 PLCPP 680
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 42-155 2.89e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 68.66  E-value: 2.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690558   42 PSCCVSSCCRPQCCQSVCCQPTCCRPTCCETTCCHPRCCISSCCRPSCcmSSCCKPQCCQSVCCQPTCCRPSCCRPCCCL 121
Cdd:pfam01500  12 PTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQTGCGGIGYGQ 89

                          90       100       110
                  ....*....|....*....|....*....|....
gi 225690558  122 RPVCGRVSCHTTCYRPTCVISTCPRPLCCASSCC 155
Cdd:pfam01500  90 EGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCT 123
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-154 5.68e-14

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 65.20  E-value: 5.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690558    3 SSCCGSVCSDQG-CSQDLCQETCCRPSCCQTTCCRTTCYRPSCCVSSCCRPQC---CQSVCCQPTCCRPTCCETTCCHPR 78
Cdd:pfam01500   7 SFCGFPTCSTGGtCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIG 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225690558   79 CCISSCCRPSCCMSSCCKPQCCQSVCCQPTCcrpscCRPCCCLRPVCGRVSCHTTCYRPTCVISTCPRPLCCASSC 154
Cdd:pfam01500  87 YGQEGSSGAVSSRTRWCRPDCRVEGTCLPPC-----CVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
44-88 5.70e-12

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 57.01  E-value: 5.70e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 225690558   44 CCVSSCCRPQCCQSVCCQPTCCRPTCCETTCCHPRCCISSCCRPS 88
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
49-90 1.87e-11

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 55.47  E-value: 1.87e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 225690558   49 CCRPQCCQSVCCQPTCCRPTCCETTCCHPRCCISSCCRPSCC 90
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
41-77 1.43e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 50.84  E-value: 1.43e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 225690558   41 RPSCCVSSCCRPQCCQSVCCQPTCCRPTCCETTCCHP 77
Cdd:pfam13885   8 QPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQP 44
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
69-108 4.49e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 49.30  E-value: 4.49e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 225690558   69 CCETTCCHPRCCISSCCRPSCCMSSCCKPQCCQSVCCQPT 108
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSS 40
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
74-109 1.02e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 43.14  E-value: 1.02e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 225690558   74 CCHPRCCISSCCRPSCCMSSCCKPQCCQSVCCQPTC 109
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSC 36
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
24-108 3.51e-06

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 45.31  E-value: 3.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690558  24 CCRPSCCQTTCCRTTCYRPSCCvssCCRPQCCqsvCCQPTCCRPTCCETTCCHPRCCISSCCRPSCCMssCCkpQCCQSV 103
Cdd:COG3901  606 FRRLCLLGLALAAAALARRRLW---RRRRREC---CCGCCCCCCKCCCIVIIIDGIIIINECCCCCCL--CC--RRCQDD 675


                 ....*
gi 225690558 104 CCQPT 108
Cdd:COG3901  676 PLCPP 680
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
15-68 9.22e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 40.83  E-value: 9.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 225690558   15 CSQDLCQETCCRPSCCqttccrttcyRPSCCVSSCCRPQCCQSVCCQPTCCRPT 68
Cdd:pfam13885   2 CQPSCCQPSCCQPSCC----------QPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
79-110 1.49e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 40.06  E-value: 1.49e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 225690558   79 CCISSCCRPSCCMSSCCKPQCCQSVCCQPTCC 110
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCC 32
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 1-155 2.04e-04

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 39.80  E-value: 2.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690558    1 MVSSCCGSVCSDQGCSQDLC-QETCCRPSCCQTTCCRTTCYRPSCCVSSCCRPQCCQSVCCQPTCCRPTCCETTCCHPRC 79
Cdd:pfam05287   1 MSYNCCSGNFSSRSLRNHLHyPVSSCGSSCPSNLSYSTDLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSY 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 225690558   80 CISSCCRPSCCM-SSCCKPQCCQSVCCQPTCCRPSCCRPCCCLRPVCGRVSCHTTCYRPTCVISTCPRPLCCASSCC 155
Cdd:pfam05287  81 CVPSPCQRSCYSpRTSCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGYGSSFC 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
84-147 1.17e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.05  E-value: 1.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 225690558   84 CCRPSCCMSSCCKPQCCQSVCCQPTCCrpsccrpccclrpvcgrvscHTTCYRPTCVISTCPRP 147
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCC--------------------QPSCCRPSCCRSSCCQP 44
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 5-140 1.64e-03

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 37.10  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225690558    5 CCGSVCSDQGCSQDLCQETCCRPSCCQTTCCRTTCYRPSCCVSSCCRPQC------CQSVCCQPTCCRPTCCETTCCHPR 78
Cdd:pfam05287  41 CSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVPSPCQRSCysprtsCVCSPCQTTSAGSLGFGSSSCQSL 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225690558   79 CCISSCCRPSCCMSSCCKPQCCQSVCCQPtccrpSCCRPCCCLRPVCGRVSCHTTCYRPTCV 140
Cdd:pfam05287 121 GYGSNSCQPLGCGSSGFRPLGCLSKGFQS-----LGYGSSFCRPSYVSSRSYQPSCFRPSCG 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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