|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
126-542 |
1.56e-150 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 444.59 E-value: 1.56e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 126 SFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRvqAIRVLVLTPT 205
Cdd:COG0513 3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPR--APQALILAPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 206 RELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSmSVDLEDLAVLILDEADRLLE 285
Cdd:COG0513 81 RELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERG-ALDLSGVETLVLDEADRMLD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 286 LGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRLAADPSTKRPATLTEEVVRIRRMREvnQEAVLLALC 365
Cdd:COG0513 160 MGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDK--LELLRRLLR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 366 SKTFTaKAIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLDIIGVQTVINY 445
Cdd:COG0513 238 DEDPE-RAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 446 ACPRDLTSYVHRVGRTARAGREGYAVTFVTDNDRSLLKSIVKRAGSKLRSRIVAEQSIIKWSHmIEQMEDQVAAILQEER 525
Cdd:COG0513 317 DLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQKIEEEELPGFEPVEEKR-LERLKPKIKEKLKGKK 395
|
410
....*....|....*..
gi 225457931 526 EERILRKAEMEATKAEN 542
Cdd:COG0513 396 AGRGGRPGPKGERKARR 412
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
136-330 |
5.31e-121 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 360.03 E-value: 5.31e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQAIRVLVLTPTRELAVQVHSM 215
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKKKAATRVLVLVPTRELAMQCFSV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 216 MEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMSVDLEDLAVLILDEADRLLELGFNAEIREL 295
Cdd:cd17947 81 LQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFDLDSIEILVLDEADRMLEEGFADELKEI 160
|
170 180 190
....*....|....*....|....*....|....*
gi 225457931 296 VRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRL 330
Cdd:cd17947 161 LRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
127-500 |
1.17e-93 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 298.01 E-value: 1.17e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 127 FLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLL-FRPKRVQAIRVLVLTPT 205
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLdFPRRKSGPPRILILTPT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 206 RELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSmSVDLEDLAVLILDEADRLLE 285
Cdd:PRK11192 83 RELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEE-NFDCRAVETLILDEADRMLD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 286 LGFNAEIRELVRLCPKRRQTMLFSATMT-EEVDELVKLSMTKPMRLAADPSTKRPATLTEEVVRIRRMRevNQEAVLLAL 364
Cdd:PRK11192 162 MGFAQDIETIAAETRWRKQTLLFSATLEgDAVQDFAERLLNDPVEVEAEPSRRERKKIHQWYYRADDLE--HKTALLCHL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 365 CSKTFTAKAIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLDIIGVQTVIN 444
Cdd:PRK11192 240 LKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVIN 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 225457931 445 YACPRDLTSYVHRVGRTARAGREGYAVTFVTDNDRSLLKSIVKRAGSKLRSRIVAE 500
Cdd:PRK11192 320 FDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIERYIEEPLKARVIDE 375
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
124-478 |
1.30e-93 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 299.02 E-value: 1.30e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 124 ANSFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQAirvLVLT 203
Cdd:PRK11776 3 MTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQA---LVLC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 204 PTRELAVQVHSMMEKLAQFTD-IRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSmSVDLEDLAVLILDEADR 282
Cdd:PRK11776 80 PTRELADQVAKEIRRLARFIPnIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKG-TLDLDALNTLVLDEADR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 283 LLELGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRLAADPstkrpatlTEEVVRIR-RMREVN----Q 357
Cdd:PRK11776 159 MLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVES--------THDLPAIEqRFYEVSpderL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 358 EAVLLALcSKTFTAKAIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLDII 437
Cdd:PRK11776 231 PALQRLL-LHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIK 309
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 225457931 438 GVQTVINYACPRDLTSYVHRVGRTARAGREGYAVTFVTDND 478
Cdd:PRK11776 310 ALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEE 350
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
136-330 |
7.61e-89 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 276.63 E-value: 7.61e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPK-RVQAIRVLVLTPTRELAVQVHS 214
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKkKGRGPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 215 MMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSmSVDLEDLAVLILDEADRLLELGFNAEIRE 294
Cdd:cd00268 81 VARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERG-KLDLSNVKYLVLDEADRMLDMGFEEDVEK 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 225457931 295 LVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRL 330
Cdd:cd00268 160 ILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
126-485 |
1.48e-82 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 274.80 E-value: 1.48e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 126 SFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLlfrPKRVQAIRVLVLTPT 205
Cdd:PRK11634 7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNL---DPELKAPQILVLAPT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 206 RELAVQVHSMMEKLA-QFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSmSVDLEDLAVLILDEADRLL 284
Cdd:PRK11634 84 RELAVQVAEAMTDFSkHMRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRG-TLDLSKLSGLVLDEADEML 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 285 ELGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRLAADPS-TKRPaTLTEEVVRIRRMREvnQEAVLLA 363
Cdd:PRK11634 163 RMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSvTTRP-DISQSYWTVWGMRK--NEALVRF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 364 LCSKTFTAkAIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLDIIGVQTVI 443
Cdd:PRK11634 240 LEAEDFDA-AIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVV 318
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 225457931 444 NYACPRDLTSYVHRVGRTARAGREGYAVTFVTDNDRSLLKSI 485
Cdd:PRK11634 319 NYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNI 360
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
127-473 |
1.97e-80 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 262.99 E-value: 1.97e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 127 FLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRP----KRVQAIRVLVL 202
Cdd:PRK04837 10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPapedRKVNQPRALIM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 203 TPTRELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMsVDLEDLAVLILDEADR 282
Cdd:PRK04837 90 APTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNH-INLGAIQVVVLDEADR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 283 LLELGFNAEIRELVRLCP--KRRQTMLFSATMTEEVDELVKLSMTKPMRLAADPSTKRPATLTEEVvrirrMREVNQE-- 358
Cdd:PRK04837 169 MFDLGFIKDIRWLFRRMPpaNQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEEL-----FYPSNEEkm 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 359 AVLLALCSKTFTAKAIIFSGTKqaaHRLKILFG-LA--GFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLD 435
Cdd:PRK04837 244 RLLQTLIEEEWPDRAIIFANTK---HRCEEIWGhLAadGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLH 320
|
330 340 350
....*....|....*....|....*....|....*...
gi 225457931 436 IIGVQTVINYACPRDLTSYVHRVGRTARAGREGYAVTF 473
Cdd:PRK04837 321 IPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
126-473 |
1.92e-79 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 264.89 E-value: 1.92e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 126 SFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRP----KRVQAIRVLV 201
Cdd:PRK04537 10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPaladRKPEDPRALI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 202 LTPTRELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMSVDLEDLAVLILDEAD 281
Cdd:PRK04537 90 LAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHACEICVLDEAD 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 282 RLLELGFNAEIRELVRLCPKR--RQTMLFSATMTEEVDELVKLSMTKPMRLAADPSTKRPATLTEevvRIRRMREVNQEA 359
Cdd:PRK04537 170 RMFDLGFIKDIRFLLRRMPERgtRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQ---RIYFPADEEKQT 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 360 VLLALCSKTFTAKAIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLDIIGV 439
Cdd:PRK04537 247 LLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGV 326
|
330 340 350
....*....|....*....|....*....|....
gi 225457931 440 QTVINYACPRDLTSYVHRVGRTARAGREGYAVTF 473
Cdd:PRK04537 327 KYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISF 360
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
126-331 |
2.72e-77 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 246.84 E-value: 2.72e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 126 SFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQAirvLVLTPT 205
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRFFA---LVLAPT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 206 RELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMSVDLEDLAVLILDEADRLLE 285
Cdd:cd17954 78 RELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKGFSLKSLKFLVMDEADRLLN 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 225457931 286 LGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRLA 331
Cdd:cd17954 158 MDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKIE 203
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
126-485 |
1.33e-76 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 253.96 E-value: 1.33e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 126 SFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFR---PKRVQAIRVLVL 202
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRqphAKGRRPVRALIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 203 TPTRELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDhLRNSMSVDLEDLAVLILDEADR 282
Cdd:PRK10590 82 TPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLD-LEHQNAVKLDQVEILVLDEADR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 283 LLELGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRLaadpSTKRPATLTEEVVRIRRMREVNQEAVLL 362
Cdd:PRK10590 161 MLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEI----EVARRNTASEQVTQHVHFVDKKRKRELL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 363 A-LCSKTFTAKAIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLDIIGVQT 441
Cdd:PRK10590 237 SqMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPH 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 225457931 442 VINYACPRDLTSYVHRVGRTARAGREGYAVTFVTDNDRSLLKSI 485
Cdd:PRK10590 317 VVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDI 360
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
127-328 |
2.38e-75 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 241.74 E-value: 2.38e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 127 FLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQAirvLVLTPTR 206
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFA---LVLTPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 207 ELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNS--MSVDLEDLAVLILDEADRLL 284
Cdd:cd17955 78 ELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSddTTKVLSRVKFLVLDEADRLL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 225457931 285 ELGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPM 328
Cdd:cd17955 158 TGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
116-494 |
1.11e-71 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 241.36 E-value: 1.11e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 116 PADGASfhanSFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQ 195
Cdd:PRK01297 82 PQEGKT----RFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKE 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 196 ----AIRVLVLTPTRELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRS-MPDVVVATPGRMIDHLRNSmSVDLE 270
Cdd:PRK01297 158 rymgEPRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEArFCDILVATPGRLLDFNQRG-EVHLD 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 271 DLAVLILDEADRLLELGFNAEIRELVRLCPKR--RQTMLFSATMTEEVDELVKLSMTKPMRLAADPSTKRPATLTEEVVR 348
Cdd:PRK01297 237 MVEVMVLDEADRMLDMGFIPQVRQIIRQTPRKeeRQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYA 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 349 IRRMrevNQEAVLLALCSKTFTAKAIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATD 428
Cdd:PRK01297 317 VAGS---DKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATD 393
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225457931 429 VAARGLDIIGVQTVINYACPRDLTSYVHRVGRTARAGREGYAVTFVTDNDRSLLKSIVKRAGSKLR 494
Cdd:PRK01297 394 VAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEELLGRKIS 459
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
126-487 |
1.87e-67 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 231.97 E-value: 1.87e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 126 SFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRP--KRVQAIRVLVLT 203
Cdd:PTZ00110 131 SFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQPllRYGDGPIVLVLA 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 204 PTRELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMSvDLEDLAVLILDEADRL 283
Cdd:PTZ00110 211 PTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVT-NLRRVTYLVLDEADRM 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 284 LELGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVK-LSMTKPMR-------LAADPSTKRPATLTEEVVRIRRMREV 355
Cdd:PTZ00110 290 LDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARdLCKEEPVHvnvgsldLTACHNIKQEVFVVEEHEKRGKLKML 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 356 NQEAVllalcskTFTAKAIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLD 435
Cdd:PTZ00110 370 LQRIM-------RDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLD 442
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 225457931 436 IIGVQTVINYACPRDLTSYVHRVGRTARAGREGYAVTFVTDNDRSLLKSIVK 487
Cdd:PTZ00110 443 VKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPDKYRLARDLVK 494
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
126-327 |
8.80e-66 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 216.40 E-value: 8.80e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 126 SFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVqAIRVLVLTPT 205
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTV-GARALILSPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 206 RELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIdHLRNSMSVDLEDLAVLILDEADRLLE 285
Cdd:cd17959 81 RELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLL-HLLVEMNLKLSSVEYVVFDEADRLFE 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 225457931 286 LGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKP 327
Cdd:cd17959 160 MGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEP 201
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
125-485 |
2.08e-62 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 214.31 E-value: 2.08e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 125 NSFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRpkrVQAIRVLVLTP 204
Cdd:PTZ00424 28 DSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYD---LNACQALILAP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 205 TRELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLrNSMSVDLEDLAVLILDEADRLL 284
Cdd:PTZ00424 105 TRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMI-DKRHLRVDDLKLFILDEADEML 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 285 ELGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRLAAdpstkRPATLTEEVVRIRRMREVNQEAVLLAL 364
Cdd:PTZ00424 184 SRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILV-----KKDELTLEGIRQFYVAVEKEEWKFDTL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 365 CS--KTFT-AKAIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLDIIGVQT 441
Cdd:PTZ00424 259 CDlyETLTiTQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSL 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 225457931 442 VINYACPRDLTSYVHRVGRTARAGREGYAVTFVTDNDRSLLKSI 485
Cdd:PTZ00424 339 VINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEI 382
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
132-322 |
2.62e-61 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 204.35 E-value: 2.62e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 132 LSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRV---QAIRVLVLTPTREL 208
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESgeeQGTRALILVPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 209 AVQVHSMMEKLAQFT--DIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMSVDLEDLAVLILDEADRLLEL 286
Cdd:cd17961 81 AQQVSKVLEQLTAYCrkDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVLSY 160
|
170 180 190
....*....|....*....|....*....|....*.
gi 225457931 287 GFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKL 322
Cdd:cd17961 161 GYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKL 196
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
136-329 |
2.01e-59 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 199.34 E-value: 2.01e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQ--AIRVLVLTPTRELAVQVH 213
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANLKkgQVGALIISPTRELATQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 214 SMMEKLA--QFTDIRCCLIVGGLSSKMQ-ETALRSMPDVVVATPGRMIDHL-RNSMSVDLEDLAVLILDEADRLLELGFN 289
Cdd:cd17960 81 EVLQSFLehHLPKLKCQLLIGGTNVEEDvKKFKRNGPNILVGTPGRLEELLsRKADKVKVKSLEVLVLDEADRLLDLGFE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 225457931 290 AEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMR 329
Cdd:cd17960 161 ADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVR 200
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
137-327 |
2.74e-59 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 198.67 E-value: 2.74e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 137 LRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLlFRPK--RVQAIRVLVLTPTRELAVQVHS 214
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKL-YRERwtPEDGLGALIISPTRELAMQIFE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 215 MMEKLAQFTDIRCCLIVGGLSSKMQETALRSMpDVVVATPGRMIDHLRNSMSVDLEDLAVLILDEADRLLELGFNAEIRE 294
Cdd:cd17941 81 VLRKVGKYHSFSAGLIIGGKDVKEEKERINRM-NILVCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDMGFKETLDA 159
|
170 180 190
....*....|....*....|....*....|...
gi 225457931 295 LVRLCPKRRQTMLFSATMTEEVDELVKLSMTKP 327
Cdd:cd17941 160 IVENLPKSRQTLLFSATQTKSVKDLARLSLKNP 192
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
137-327 |
4.27e-59 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 198.35 E-value: 4.27e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 137 LRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLE---RLLFRPKRVQAirVLVLTPTRELAVQVH 213
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIEllyKLKFKPRNGTG--VIIISPTRELALQIY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 214 SMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMSVDLEDLAVLILDEADRLLELGFNAEIR 293
Cdd:cd17942 80 GVAKELLKYHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEADRILEIGFEEEMR 159
|
170 180 190
....*....|....*....|....*....|....
gi 225457931 294 ELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKP 327
Cdd:cd17942 160 QIIKLLPKRRQTMLFSATQTRKVEDLARISLKKK 193
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
126-486 |
2.55e-58 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 206.18 E-value: 2.55e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 126 SFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERL-LFRPKRVQAIR---VLV 201
Cdd:PLN00206 122 SFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCcTIRSGHPSEQRnplAMV 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 202 LTPTRELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDhLRNSMSVDLEDLAVLILDEAD 281
Cdd:PLN00206 202 LTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLID-LLSKHDIELDNVSVLVLDEVD 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 282 RLLELGFNAEIRELVRLCPKRrQTMLFSATMTEEVdELVKLSMTKPMRLAADPSTKRPATLTEEVVRIRRMREVNQEAVL 361
Cdd:PLN00206 281 CMLERGFRDQVMQIFQALSQP-QVLLFSATVSPEV-EKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQKLFD 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 362 LALCSKTFTAKAIIFSGTKQAAHRL-KILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLDIIGVQ 440
Cdd:PLN00206 359 ILKSKQHFKPPAVVFVSSRLGADLLaNAITVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVR 438
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 225457931 441 TVINYACPRDLTSYVHRVGRTARAGREGYAVTFVTDNDRSLLKSIV 486
Cdd:PLN00206 439 QVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNLFPELV 484
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
136-330 |
1.11e-57 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 194.34 E-value: 1.11e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLfRPKRVQAIRVLVLTPTRELAVQVHSM 215
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLG-KPRKKKGLRALILAPTRELASQIYRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 216 MEKLAQFTDIRCCLIvgglsSKMQETALRSMP------DVVVATPGRMIDHLRNSmSVDLEDLAVLILDEADRLLELGFN 289
Cdd:cd17957 80 LLKLSKGTGLRIVLL-----SKSLEAKAKDGPksitkyDILVSTPLRLVFLLKQG-PIDLSSVEYLVLDEADKLFEPGFR 153
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 225457931 290 AEIRELVRLCP-KRRQTMLFSATMTEEVDELVKLSMTKPMRL 330
Cdd:cd17957 154 EQTDEILAACTnPNLQRSLFSATIPSEVEELARSVMKDPIRI 195
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
132-326 |
6.76e-57 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 192.80 E-value: 6.76e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 132 LSRPLLRACEALGYTKPTPIQAACIPIAL-TGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQA--IRVLVLTPTREL 208
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILsTGDDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGRRsgVSALIISPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 209 AVQVHSMMEKLAQF-TDIRCCLIVGGLSSKMQETALRSM-PDVVVATPGRMIDHLRNSMS-VDLEDLAVLILDEADRLLE 285
Cdd:cd17964 81 ALQIAAEAKKLLQGlRKLRVQSAVGGTSRRAELNRLRRGrPDILVATPGRLIDHLENPGVaKAFTDLDYLVLDEADRLLD 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 225457931 286 LGFNAEIRELVRLCPKR----RQTMLFSATMTEEVDELVKLSMTK 326
Cdd:cd17964 161 MGFRPDLEQILRHLPEKnadpRQTLLFSATVPDEVQQIARLTLKK 205
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
126-319 |
8.30e-57 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 192.70 E-value: 8.30e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 126 SFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLL-------FRPKRVQAIR 198
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLedgppsvGRGRRKAYPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 199 VLVLTPTRELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHL-RNsmSVDLEDLAVLIL 277
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIeRG--RISLSSIKFLVL 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 225457931 278 DEADRLLELGFNAEIRELVR---LCPKR-RQTMLFSATMTEEVDEL 319
Cdd:cd17967 159 DEADRMLDMGFEPQIRKIVEhpdMPPKGeRQTLMFSATFPREIQRL 204
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
136-326 |
2.99e-56 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 192.07 E-value: 2.99e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALT-GRDICGSAITGSGKTAAFSLPTLERLL------FRPKRVQAIRVLVLTPTREL 208
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILERLLsqkssnGVGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 209 AVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHL--RNSMSVDLEDLAVLILDEADRLLEL 286
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIqeGNEHLANLKSLRFLVLDEADRMLEK 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 225457931 287 GFNAEIRELVRLCP-------KRRQTMLFSATMTEEVDELVKLSMTK 326
Cdd:cd17946 161 GHFAELEKILELLNkdragkkRKRQTFVFSATLTLDHQLPLKLNSKK 207
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
149-319 |
2.75e-55 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 186.68 E-value: 2.75e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 149 TPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKrvqAIRVLVLTPTRELAVQVHSMMEKLAQFTDIRCC 228
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDN---GPQALVLAPTRELAEQIYEELKKLGKGLGLKVA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 229 LIVGGLSSKMQETALRSmPDVVVATPGRMIDHLRNSmsVDLEDLAVLILDEADRLLELGFNAEIRELVRLCPKRRQTMLF 308
Cdd:pfam00270 78 SLLGGDSRKEQLEKLKG-PDILVGTPGRLLDLLQER--KLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLL 154
|
170
....*....|.
gi 225457931 309 SATMTEEVDEL 319
Cdd:pfam00270 155 SATLPRNLEDL 165
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
136-327 |
7.05e-54 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 184.83 E-value: 7.05e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKR-----VQAIRVLVLTPTRELAV 210
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLdeetkDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 211 QVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMSVdLEDLAVLILDEADRLLELGF-- 288
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLV-LNQCTYVVLDEADRMIDMGFep 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 225457931 289 ------------------NAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKP 327
Cdd:cd17945 160 qvtkildampvsnkkpdtEEAEKLAASGKHRYRQTMMFTATMPPAVEKIAKGYLRRP 216
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
143-330 |
3.31e-53 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 182.79 E-value: 3.31e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 143 LGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLL---FRPKRVQAIRVLVLTPTRELAVQVHSMMEKL 219
Cdd:cd17949 9 MGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLslePRVDRSDGTLALVLVPTRELALQIYEVLEKL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 220 AQ-FTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMSVDLEDLAVLILDEADRLLELGFNAEIRELVRL 298
Cdd:cd17949 89 LKpFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMGFEKDITKILEL 168
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 225457931 299 -------------CPKRRQTMLFSATMTEEVDELVKLSMTKPMRL 330
Cdd:cd17949 169 lddkrskaggeksKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
123-319 |
3.64e-53 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 184.40 E-value: 3.64e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 123 HANSFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFR------PKRVQA 196
Cdd:cd18052 41 AILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEgltassFSEVQE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 197 IRVLVLTPTRELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLrNSMSVDLEDLAVLI 276
Cdd:cd18052 121 PQALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFI-GRGKISLSKLKYLI 199
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 225457931 277 LDEADRLLELGFNAEIRELVRLC---PK-RRQTMLFSATMTEEVDEL 319
Cdd:cd18052 200 LDEADRMLDMGFGPEIRKLVSEPgmpSKeDRQTLMFSATFPEEIQRL 246
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
141-339 |
1.69e-50 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 174.99 E-value: 1.69e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 141 EALGYTKPTPIQAACIPIALTG-RDICGSAITGSGKTAAFSLPTLERLlfrpKRVQAIRVLVLTPTRELAVQVHSMMEKL 219
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEAL----KRGKGGRVLVLVPTRELAEQWAEELKKL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 220 AQFTDIRCCLIVGGLSSKMQETALRS-MPDVVVATPGRMIDHLRNSmSVDLEDLAVLILDEADRLLELGFNAEIRELVRL 298
Cdd:smart00487 78 GPSLGLKVVGLYGGDSKREQLRKLESgKTDILVTTPGRLLDLLEND-KLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKL 156
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 225457931 299 CPKRRQTMLFSATMTEEVDELVKLSMTKPMRLAADPSTKRP 339
Cdd:smart00487 157 LPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEP 197
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
129-330 |
1.26e-49 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 172.51 E-value: 1.26e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 129 ELNLSRPLLRACEALGYTKPTPI-QAACIPIaLTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQAirvLVLTPTRE 207
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIqQRAIVPI-IKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQA---LVLAPTRE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 208 LAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSmSVDLEDLAVLILDEADRLLELG 287
Cdd:cd17939 77 LAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRR-SLRTDKIKMFVLDEADEMLSRG 155
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 225457931 288 FNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRL 330
Cdd:cd17939 156 FKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRI 198
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
136-330 |
5.31e-49 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 170.67 E-value: 5.31e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRP--KRVQAIRVLVLTPTRELAVQVH 213
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRelEKGEGPIAVIVAPTRELAQQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 214 SMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSmSVDLEDLAVLILDEADRLLELGFNAEIR 293
Cdd:cd17952 81 LEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKK-ATNLQRVTYLVLDEADRMFDMGFEYQVR 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 225457931 294 ELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRL 330
Cdd:cd17952 160 SIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
342-474 |
8.60e-49 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 167.68 E-value: 8.60e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 342 LTEEVVRIRRMREVNqeAVLLALCSKTFTAKAIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQV 421
Cdd:cd18787 1 IKQLYVVVEEEEKKL--LLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKV 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 225457931 422 DFLIATDVAARGLDIIGVQTVINYACPRDLTSYVHRVGRTARAGREGYAVTFV 474
Cdd:cd18787 79 RVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
129-328 |
3.39e-48 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 169.48 E-value: 3.39e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 129 ELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRP--KRVQAIRVLVLTPTR 206
Cdd:cd17953 16 QCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRpvKPGEGPIGLIMAPTR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 207 ELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHL--RNSMSVDLEDLAVLILDEADRLL 284
Cdd:cd17953 96 ELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILtaNNGRVTNLRRVTYVVLDEADRMF 175
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 225457931 285 ELGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPM 328
Cdd:cd17953 176 DMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPI 219
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
136-328 |
2.70e-47 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 165.90 E-value: 2.70e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQairVLVLTPTRELAVQVHSM 215
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQ---VLILAPTREIAVQIHDV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 216 MEKLAQ-FTDIRCCLIVGGLSSKMQETALRSmPDVVVATPGRmIDHLRNSMSVDLEDLAVLILDEADRLLELGFNAEIRE 294
Cdd:cd17943 78 FKKIGKkLEGLKCEVFIGGTPVKEDKKKLKG-CHIAVGTPGR-IKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNW 155
|
170 180 190
....*....|....*....|....*....|....
gi 225457931 295 LVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPM 328
Cdd:cd17943 156 IFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPV 189
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
127-327 |
5.30e-47 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 165.55 E-value: 5.30e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 127 FLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLlfRPKRvQAIRVLVLTPTR 206
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKI--DPKK-DVIQALILVPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 207 ELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMSvDLEDLAVLILDEADRLLEL 286
Cdd:cd17940 78 ELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVA-DLSHCKTLVLDEADKLLSQ 156
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 225457931 287 GFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKP 327
Cdd:cd17940 157 DFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNP 197
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
136-319 |
1.40e-46 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 164.08 E-value: 1.40e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRP--KRVQAIRVLVLTPTRELAVQVH 213
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPplERGDGPIVLVLAPTRELAQQIQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 214 SMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLrNSMSVDLEDLAVLILDEADRLLELGFNAEIR 293
Cdd:cd17966 81 QEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFL-DQGKTNLRRVTYLVLDEADRMLDMGFEPQIR 159
|
170 180
....*....|....*....|....*.
gi 225457931 294 ELVRLCPKRRQTMLFSATMTEEVDEL 319
Cdd:cd17966 160 KIVDQIRPDRQTLMWSATWPKEVRRL 185
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
127-328 |
4.64e-46 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 162.88 E-value: 4.64e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 127 FLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLerllfrpkrvQAIRVLVLTPTR 206
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVL----------QIVVALILEPSR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 207 ELAVQVHSMMEKLAQFTD---IRCCLIVGGLSSKMQETALRSMPDVVVATPGRmIDHLRNSMSVDLEDLAVLILDEADRL 283
Cdd:cd17938 71 ELAEQTYNCIENFKKYLDnpkLRVALLIGGVKAREQLKRLESGVDIVVGTPGR-LEDLIKTGKLDLSSVRFFVLDEADRL 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 225457931 284 LELGFNAEIRELVRLCPK------RRQTMLFSATM-TEEVDELVKLSMTKPM 328
Cdd:cd17938 150 LSQGNLETINRIYNRIPKitsdgkRLQVIVCSATLhSFEVKKLADKIMHFPT 201
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
136-327 |
3.76e-45 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 161.26 E-value: 3.76e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALTG---------RDICGSAITGSGKTAAFSLPTLERLLFRPKRVqaIRVLVLTPTR 206
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALSKRVVPR--LRALIVVPTK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 207 ELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALR--------SMPDVVVATPGRMIDHLRNSMSVDLEDLAVLILD 278
Cdd:cd17956 79 ELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLvdtsgrylSRVDILVATPGRLVDHLNSTPGFTLKHLRFLVID 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225457931 279 EADRLLELGFN------------------AEIRELVRLCPKRR--QTMLFSATMTEEVDELVKLSMTKP 327
Cdd:cd17956 159 EADRLLNQSFQdwletvmkalgrptapdlGSFGDANLLERSVRplQKLLFSATLTRDPEKLSSLKLHRP 227
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
136-328 |
2.15e-43 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 155.57 E-value: 2.15e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQAIR-----VLVLTPTRELAV 210
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPFIKgegpyGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 211 QVHSMMEKLAQ------FTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHL-RNSMSVDLedLAVLILDEADRL 283
Cdd:cd17951 81 QTHEVIEYYCKalqeggYPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLnKKKINLDI--CRYLCLDEADRM 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 225457931 284 LELGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPM 328
Cdd:cd17951 159 IDMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPV 203
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
123-321 |
2.98e-42 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 154.04 E-value: 2.98e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 123 HANSFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLL-------------F 189
Cdd:cd18051 19 HIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYeqgpgeslpsesgY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 190 RPKRVQAIRVLVLTPTRELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMsVDL 269
Cdd:cd18051 99 YGRRKQYPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGK-IGL 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 225457931 270 EDLAVLILDEADRLLELGFNAEIRELVRLC--PKR--RQTMLFSATMTEEVDELVK 321
Cdd:cd18051 178 DYCKYLVLDEADRMLDMGFEPQIRRIVEQDtmPPTgeRQTLMFSATFPKEIQMLAR 233
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
136-330 |
5.09e-42 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 151.16 E-value: 5.09e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQAirvLVLTPTRELAVQVHSM 215
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPSA---LILTPTRELAVQIEDQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 216 MEKLAQ-FTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSmSVDLEDLAVLILDEADRLLELGFNAEIRE 294
Cdd:cd17962 78 AKELMKgLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQS-SVELDNIKIVVVDEADTMLKMGFQQQVLD 156
|
170 180 190
....*....|....*....|....*....|....*.
gi 225457931 295 LVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRL 330
Cdd:cd17962 157 ILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
136-328 |
1.16e-41 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 150.31 E-value: 1.16e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRP-KRVQAIR--VLVLTPTRELAVQV 212
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPiPREQRNGpgVLVLTPTRELALQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 213 HSMMEKLAqFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDhLRNSMSVDLEDLAVLILDEADRLLELGFNAEI 292
Cdd:cd17958 81 EAECSKYS-YKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLND-LQMNNVINLKSITYLVLDEADRMLDMGFEPQI 158
|
170 180 190
....*....|....*....|....*....|....*.
gi 225457931 293 RELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPM 328
Cdd:cd17958 159 RKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPM 194
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
127-330 |
8.47e-41 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 148.36 E-value: 8.47e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 127 FLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQAirvLVLTPTR 206
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQA---LVLAPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 207 ELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHL-RNSMSVDleDLAVLILDEADRLLE 285
Cdd:cd18046 78 ELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMInRRYLRTD--YIKMFVLDEADEMLS 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 225457931 286 LGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRL 330
Cdd:cd18046 156 RGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRI 200
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
132-336 |
2.15e-40 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 146.95 E-value: 2.15e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 132 LSRPLLRACEALGYTKPTPIQAACIPIALTG--RDICGSAITGSGKTAAFSLPTLERLLFRPKRVQAirvLVLTPTRELA 209
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQA---LCLAPTRELA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 210 VQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSmpdVVVATPGRMIDHLRnSMSVDLEDLAVLILDEADRLLEL-GF 288
Cdd:cd17963 78 RQIGEVVEKMGKFTGVKVALAVPGNDVPRGKKITAQ---IVIGTPGTVLDWLK-KRQLDLKKIKILVLDEADVMLDTqGH 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 225457931 289 NAEIRELVRLCPKRRQTMLFSATMTEEVDELVKlsmtkpmRLAADPST 336
Cdd:cd17963 154 GDQSIRIKRMLPRNCQILLFSATFPDSVRKFAE-------KIAPNANT 194
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
126-330 |
5.46e-40 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 145.95 E-value: 5.46e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 126 SFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQairVLVLTPT 205
Cdd:cd17950 3 GFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVS---VLVICHT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 206 RELAVQVHSMMEKLAQF-TDIRCCLIVGGLSSKMQETALRSM-PDVVVATPGRMIDHLRNSmSVDLEDLAVLILDEADRL 283
Cdd:cd17950 80 RELAFQISNEYERFSKYmPNVKTAVFFGGVPIKKDIEVLKNKcPHIVVGTPGRILALVREK-KLKLSHVKHFVLDECDKM 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 225457931 284 LE-LGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRL 330
Cdd:cd17950 159 LEqLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEI 206
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
127-321 |
2.62e-36 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 136.68 E-value: 2.62e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 127 FLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRP--KRVQAIRVLVLTP 204
Cdd:cd18049 26 FYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPflERGDGPICLVLAP 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 205 TRELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMSvDLEDLAVLILDEADRLL 284
Cdd:cd18049 106 TRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKT-NLRRCTYLVLDEADRML 184
|
170 180 190
....*....|....*....|....*....|....*..
gi 225457931 285 ELGFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVK 321
Cdd:cd18049 185 DMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAE 221
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
127-330 |
9.22e-35 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 131.05 E-value: 9.22e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 127 FLELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLlfrPKRVQAIRVLVLTPTR 206
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCL---DIQVRETQALILSPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 207 ELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSmSVDLEDLAVLILDEADRLLEL 286
Cdd:cd18045 78 ELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRR-SLRTRHIKMLVLDEADEMLNK 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 225457931 287 GFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKPMRL 330
Cdd:cd18045 157 GFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
145-321 |
3.12e-34 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 132.06 E-value: 3.12e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 145 YTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRP--KRVQAIRVLVLTPTRELAVQVHSMMEKLAQF 222
Cdd:cd18050 82 FKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPylERGDGPICLVLAPTRELAQQVQQVADDYGKS 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 223 TDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRnSMSVDLEDLAVLILDEADRLLELGFNAEIRELVRLCPKR 302
Cdd:cd18050 162 SRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLE-AGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPD 240
|
170
....*....|....*....
gi 225457931 303 RQTMLFSATMTEEVDELVK 321
Cdd:cd18050 241 RQTLMWSATWPKEVRQLAE 259
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
136-319 |
7.60e-33 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 126.71 E-value: 7.60e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRP----KRVQAIRVLVLTPTRELAVQ 211
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKllaeGPFNAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 212 VHSMMEKLAQFTDIRCCLIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMsVDLEDLAVLILDEADRLLELGFNAE 291
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRI-YSLEQLRHLVLDEADTLLDDSFNEK 159
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 225457931 292 IRELVRLCP--KRR-----------QTMLFSATMTEEVDEL 319
Cdd:cd17948 160 LSHFLRRFPlaSRRsentdgldpgtQLVLVSATMPSGVGEV 200
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
359-465 |
1.28e-30 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 116.16 E-value: 1.28e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 359 AVLLALCSKTFTAKAIIFSGTKQAAHrLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLDIIG 438
Cdd:pfam00271 4 EALLELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPD 82
|
90 100
....*....|....*....|....*..
gi 225457931 439 VQTVINYACPRDLTSYVHRVGRTARAG 465
Cdd:pfam00271 83 VDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
141-326 |
4.82e-30 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 117.64 E-value: 4.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 141 EALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERL---LFRPKRVQAIRVLVLTPTRELAVQVHSMME 217
Cdd:cd17944 6 QARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLqedQQPRKRGRAPKVLVLAPTRELANQVTKDFK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 218 KLAQFTDIRCclIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSmSVDLEDLAVLILDEADRLLELGFNAEIRELVR 297
Cdd:cd17944 86 DITRKLSVAC--FYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNG-RLDLTKLKHVVLDEVDQMLDMGFAEQVEEILS 162
|
170 180 190
....*....|....*....|....*....|....
gi 225457931 298 LCPKRR-----QTMLFSATMTEEVDELVKLSMTK 326
Cdd:cd17944 163 VSYKKDsednpQTLLFSATCPDWVYNVAKKYMKS 196
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
385-465 |
4.56e-24 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 96.51 E-value: 4.56e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 385 RLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLDIIGVQTVINYACPRDLTSYVHRVGRTARA 464
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRA 81
|
.
gi 225457931 465 G 465
Cdd:smart00490 82 G 82
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
122-316 |
5.88e-23 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 98.17 E-value: 5.88e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 122 FHANSFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTG--RDICGSAITGSGKTAAFSLPTLERLLFRPKRVQAirv 199
Cdd:cd18048 15 FSVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQC--- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 200 LVLTPTRELAVQVHSMMEKLAQF-TDIRcclIVGGLSSKMQETALRSMPDVVVATPGRMIDHLRNSMSVDLEDLAVLILD 278
Cdd:cd18048 92 LCLSPTFELALQTGKVVEEMGKFcVGIQ---VIYAIRGNRPGKGTDIEAQIVIGTPGTVLDWCFKLRLIDVTNISVFVLD 168
|
170 180 190
....*....|....*....|....*....|....*....
gi 225457931 279 EADRLLEL-GFNAEIRELVRLCPKRRQTMLFSATMTEEV 316
Cdd:cd18048 169 EADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSV 207
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
171-629 |
1.20e-18 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 90.08 E-value: 1.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 171 TGSGKTAAFSLpTLERLLFRPkrvqaiRVLVLTPTRELAVQvhsMMEKLAQFTDIRcclIVGGLSSKMQEtalrsmpDVV 250
Cdd:COG1061 109 TGTGKTVLALA-LAAELLRGK------RVLVLVPRRELLEQ---WAEELRRFLGDP---LAGGGKKDSDA-------PIT 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 251 VATPGRMIDHLRNSMSVDLEDLavLILDEADRLLELGFnaeiRELVRLCPKRRqTMLFSAT------MTEEVDELVKLSM 324
Cdd:COG1061 169 VATYQSLARRAHLDELGDRFGL--VIIDEAHHAGAPSY----RRILEAFPAAY-RLGLTATpfrsdgREILLFLFDGIVY 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 325 TKPMRLAAD-----------------PSTKRPATLTEEVV-RIRRMREVNQEAVLLALCSKTFTAKAIIFSGTKQAAHRL 386
Cdd:COG1061 242 EYSLKEAIEdgylappeyygirvdltDERAEYDALSERLReALAADAERKDKILRELLREHPDDRKTLVFCSSVDHAEAL 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 387 KILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLDIIGVQTVINYACPRDLTSYVHRVGRTARAGR 466
Cdd:COG1061 322 AELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAP 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 467 EGYAVTF--VTDNDRSLLKSIVKRAGSKLRSRIVAEQSIIKWSHMIEQMEDQVAAILQEEREERILRKAEMEATKAENMI 544
Cdd:COG1061 402 GKEDALVydFVGNDVPVLEELAKDLRDLAGYRVEFLDEEESEELALLIAVKPALEVKGELEEELLEELELLEDALLLVLA 481
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 545 AHKDDIYSRPKRTWFATEKEKKSVAKAAKDSLEKENGSGNNVISAQQAEDLKMKEKRKREREKNLPRKKRRKLEAARERL 624
Cdd:COG1061 482 ELLLLELLALALELLELAKAEGKAEEEEEEKELLLLLALAKLLKLLLLLLLLLLLELLELLAALLRLEELAALLLKELLR 561
|
....*
gi 225457931 625 EDENQ 629
Cdd:COG1061 562 AALAA 566
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
126-327 |
4.23e-18 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 83.23 E-value: 4.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 126 SFLELNLSRPLLRACEALGYTKPTPIQAACIPIALTG--RDICGSAITGSGKTAAFSLPTLERLLFRPKRVQAirvLVLT 203
Cdd:cd18047 2 SFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQC---LCLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 204 PTRELAVQVHSMMEKLAQF-TDIRCCLIVGGlssKMQETALRSMPDVVVATPGRMIDHLRNSMSVDLEDLAVLILDEADR 282
Cdd:cd18047 79 PTYELALQTGKVIEQMGKFyPELKLAYAVRG---NKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADV 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 225457931 283 LLEL-GFNAEIRELVRLCPKRRQTMLFSATMTEEVDELVKLSMTKP 327
Cdd:cd18047 156 MIATqGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
169-311 |
1.53e-17 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 79.75 E-value: 1.53e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 169 AITGSGKTAAFSLPTLERLLFRPKRVqairvLVLTPTRELAVQVHSMMEKLAQfTDIRCCLIVGGLSSKMQETALRSMPD 248
Cdd:cd00046 8 APTGSGKTLAALLAALLLLLKKGKKV-----LVLVPTKALALQTAERLRELFG-PGIRVAVLVGGSSAEEREKNKLGDAD 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225457931 249 VVVATPGRMIDHLRNSMSVDLEDLAVLILDEADRLLELGFNAEIREL--VRLCPKRRQTMLFSAT 311
Cdd:cd00046 82 IIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLavRKAGLKNAQVILLSAT 146
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
143-317 |
1.55e-15 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 77.03 E-value: 1.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 143 LGYTKPTPIQAACIPIALTGRDICG----------------SAITGSGKTAAFSLPTLERL--------LFRPKRVQ--- 195
Cdd:cd17965 26 DEEIKPSPIQTLAIKKLLKTLMRKVtkqtsneepklevfllAAETGSGKTLAYLAPLLDYLkrqeqepfEEAEEEYEsak 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 196 ---AIRVLVLTPTRELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQETAL--RSMPDVVVATPGRMIDHLRNSMSVdLE 270
Cdd:cd17965 106 dtgRPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFGPSYQRLQLafKGRIDILVTTPGKLASLAKSRPKI-LS 184
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 225457931 271 DLAVLILDEADRLLELGFNAEIRELVRLCPKRRQTMLFSATMTEEVD 317
Cdd:cd17965 185 RVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKEFD 231
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
136-581 |
5.35e-12 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 68.77 E-value: 5.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 136 LLRACEALGYTKPTPIQAACIP-IALTGRDICGSAITGSGKTAAFSLPTLERLLfrpkrvQAIRVLVLTPTRELAVQVHS 214
Cdd:COG1204 11 VIEFLKERGIEELYPPQAEALEaGLLEGKNLVVSAPTASGKTLIAELAILKALL------NGGKALYIVPLRALASEKYR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 215 MMEKLAQFTDIRccliVGGLSSKMQETALRSM-PDVVVATPGRMIDHLRNSMSVdLEDLAVLILDEA------DRllelG 287
Cdd:COG1204 85 EFKRDFEELGIK----VGVSTGDYDSDDEWLGrYDILVATPEKLDSLLRNGPSW-LRDVDLVVVDEAhliddeSR----G 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 288 FNAE--IRELVRLCPkRRQTMLFSATM--TEEVDELvklsmtkpmrLAADP--STKRPATLTEEVV--RIRRMREVNQEA 359
Cdd:COG1204 156 PTLEvlLARLRRLNP-EAQIVALSATIgnAEEIAEW----------LDAELvkSDWRPVPLNEGVLydGVLRFDDGSRRS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 360 --VLLALCSKTF--TAKAIIFSGTKQAA------------------------------HRLKILFGLaGFKAAEL----- 400
Cdd:COG1204 225 kdPTLALALDLLeeGGQVLVFVSSRRDAeslakkladelkrrltpeereeleelaeelLEVSEETHT-NEKLADClekgv 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 401 ---HGNLTQVQRlDALE-LFRKQQVDFLIATD-VAArgldiiGV----QTVInyacprdLTSYvHRVGRTA--------- 462
Cdd:COG1204 304 afhHAGLPSELR-RLVEdAFREGLIKVLVATPtLAA------GVnlpaRRVI-------IRDT-KRGGMVPipvlefkqm 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 463 --RAGR-----EGYAVTFV--TDNDRSLLKSIVKRAGSKLRSRIVAEQSIIkwSHMIeqmedqvAAILQEEREERilrka 533
Cdd:COG1204 369 agRAGRpgydpYGEAILVAksSDEADELFERYILGEPEPIRSKLANESALR--THLL-------ALIASGFANSR----- 434
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 225457931 534 emeatkaenmiahkDDIYSRPKRTWFATEKEKKSVAKAAKDSLE--KENG 581
Cdd:COG1204 435 --------------EELLDFLENTFYAYQYDKGDLEEVVDDALEflLENG 470
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
128-478 |
6.62e-11 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 65.63 E-value: 6.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 128 LELNLSRPLLRACEALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKrvqaIRVLVLTPTRE 207
Cdd:COG1205 37 WPDWLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDPG----ATALYLYPTKA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 208 LAV-QVHSMMEkLAQFT--DIRCCLIVGGLSSKmQETALRSMPDVVVATPGrMIDH--LRNSMSVD--LEDLAVLILDEA 280
Cdd:COG1205 113 LARdQLRRLRE-LAEALglGVRVATYDGDTPPE-ERRWIREHPDIVLTNPD-MLHYglLPHHTRWArfFRNLRYVVIDEA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 281 D----------RLLelgfnaeIRELVRLCPKRRQTMLF---SATMteevdelvklsmtkpmrlaADPS------TKRPAT 341
Cdd:COG1205 190 HtyrgvfgshvANV-------LRRLRRICRHYGSDPQFilaSATI-------------------GNPAehaerlTGRPVT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 342 LTEE----------------VVRIRRMREVNQEAVLLAlcsKTFT---AKAIIFSGTKQAAHRLKILF------------ 390
Cdd:COG1205 244 VVDEdgsprgertfvlwnppLVDDGIRRSALAEAARLL---ADLVregLRTLVFTRSRRGAELLARYArralrepdladr 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 391 ------GL---------AGFKAAELHG----NltqvqrldALELfrkqqvdfliatdvaarGLDIIGVQTVINYACPRDL 451
Cdd:COG1205 321 vaayraGYlpeerreieRGLRSGELLGvvstN--------ALEL-----------------GIDIGGLDAVVLAGYPGTR 375
|
410 420
....*....|....*....|....*..
gi 225457931 452 TSYVHRVGRTARAGREGYAVtFVTDND 478
Cdd:COG1205 376 ASFWQQAGRAGRRGQDSLVV-LVAGDD 401
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
152-312 |
2.26e-10 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 60.29 E-value: 2.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 152 QAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLfRPKRVQAirvLVLTPTRELAV-QVHSMMEKLAQF-TDIRCCL 229
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALL-RDPGSRA---LYLYPTKALAQdQLRSLRELLEQLgLGIRVAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 230 IVGGLSSKMQETALRSMPDVVVATPgRMIDH--LRNSMSVD--LEDLAVLILDEADRlLELGFNAE----IRELVRLCPK 301
Cdd:cd17923 81 YDGDTPREERRAIIRNPPRILLTNP-DMLHYalLPHHDRWArfLRNLRYVVLDEAHT-YRGVFGSHvallLRRLRRLCRR 158
|
170
....*....|....
gi 225457931 302 RR---QTMLFSATM 312
Cdd:cd17923 159 YGadpQFILTSATI 172
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
371-464 |
2.86e-10 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 58.76 E-value: 2.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 371 AKAIIFSGTKQAAHRLKILF-----GLAGFKAAEL--HGNLTQVQRL--------DALELFRKQQVDFLIATDVAARGLD 435
Cdd:cd18802 26 FRGIIFVERRATAVVLSRLLkehpsTLAFIRCGFLigRGNSSQRKRSlmtqrkqkETLDKFRDGELNLLIATSVLEEGID 105
|
90 100
....*....|....*....|....*....
gi 225457931 436 IIGVQTVINYACPRDLTSYVHRVGRtARA 464
Cdd:cd18802 106 VPACNLVIRFDLPKTLRSYIQSRGR-ARA 133
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
145-460 |
2.75e-08 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 57.42 E-value: 2.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 145 YTKPTPIQAACIPIALTGRDICGSAITGSGKT-AAFsLPTLERLLFRP---KRVQAIRVLVLTPTRELAVQVH-SMMEKL 219
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGESTLLIAPTGSGKTlAAF-LPALDELARRPrpgELPDGLRVLYISPLKALANDIErNLRAPL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 220 AQFTDIRCCLIV--------GGLSSKMQETALRSMPDVVVATP-----------GRMIdhlrnsmsvdLEDLAVLILDE- 279
Cdd:COG1201 101 EEIGEAAGLPLPeirvgvrtGDTPASERQRQRRRPPHILITTPeslallltspdAREL----------LRGVRTVIVDEi 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 280 ---AD--R--LLELGfnaeIRELVRLCPKRRQTMLFSATMtEEVDE----LVKLSMTKPMRLAADPSTKRP--ATLTEEV 346
Cdd:COG1201 171 halAGskRgvHLALS----LERLRALAPRPLQRIGLSATV-GPLEEvarfLVGYEDPRPVTIVDAGAGKKPdlEVLVPVE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 347 VRIRRMR---EVNQEAV--LLALC--SKTftakAIIF----SGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALEL 415
Cdd:COG1201 246 DLIERFPwagHLWPHLYprVLDLIeaHRT----TLVFtntrSQAERLFQRLNELNPEDALPIAAHHGSLSREQRLEVEEA 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 225457931 416 FRKQQVDFLIAT---DVaarGLDIIGVQTVINYACPRDLTSYVHRVGR 460
Cdd:COG1201 322 LKAGELRAVVATsslEL---GIDIGDVDLVIQVGSPKSVARLLQRIGR 366
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
372-445 |
3.88e-08 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 52.48 E-value: 3.88e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225457931 372 KAIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRK--QQVDFLIATDVAARGLDIIGVQTVINY 445
Cdd:cd18793 29 KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEdpDIRVFLLSTKAGGVGLNLTAANRVILY 104
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
149-311 |
4.19e-08 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 53.80 E-value: 4.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 149 TPIQAACI-PIALTGRDICGSAITGSGKTAAFSLPTLERLlfrpkRVQAIRVLVLTPTRELAVQVHSMMEKLAQFTDIRC 227
Cdd:cd17921 3 NPIQREALrALYLSGDSVLVSAPTSSGKTLIAELAILRAL-----ATSGGKAVYIAPTRALVNQKEADLRERFGPLGKNV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 228 CLIVGGLSSKMQETALrsmPDVVVATPGRMIDHLRNSMSVDLEDLAVLILDEA------DR--LLELGfnaeIRELVRLC 299
Cdd:cd17921 78 GLLTGDPSVNKLLLAE---ADILVATPEKLDLLLRNGGERLIQDVRLVVVDEAhligdgERgvVLELL----LSRLLRIN 150
|
170
....*....|..
gi 225457931 300 PKRRQTMLfSAT 311
Cdd:cd17921 151 KNARFVGL-SAT 161
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
423-474 |
1.00e-07 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 49.62 E-value: 1.00e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 225457931 423 FLIATDVAARGLDIIGVQTVINYACPRDLTSYVHRVGRTARAG-REGYAVTFV 474
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGkDEGEVILFV 77
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
171-280 |
3.81e-07 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 51.11 E-value: 3.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 171 TGSGKT--AAF---SLPTLERLLFRPKRvqaiRVLVLTPTRELAVQvhsmmeklaQFTDIR--CCLIVGGLSSKMQETAL 243
Cdd:cd18034 25 TGSGKTliAVMlikEMGELNRKEKNPKK----RAVFLVPTVPLVAQ---------QAEAIRshTDLKVGEYSGEMGVDKW 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 225457931 244 RSM--------PDVVVATPGRMIDHLRNSMsVDLEDLAVLILDEA 280
Cdd:cd18034 92 TKErwkeelekYDVLVMTAQILLDALRHGF-LSLSDINLLIFDEC 135
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
171-311 |
9.04e-07 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 48.84 E-value: 9.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 171 TGSGKTA-AFSLPtleRLLFRPkrvqaiRVLVLTPTRELAVQvhsMMEKLAQFTDIRCCLIVGGLSSKMQETAlrsmpDV 249
Cdd:cd17926 27 TGSGKTLtALALI---AYLKEL------RTLIVVPTDALLDQ---WKERFEDFLGDSSIGLIGGGKKKDFDDA-----NV 89
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225457931 250 VVATPgrmidhlrNSMSVDLEDL-------AVLILDEADRLLELGFNAEIRELvrLCPKRrqtMLFSAT 311
Cdd:cd17926 90 VVATY--------QSLSNLAEEEkdlfdqfGLLIVDEAHHLPAKTFSEILKEL--NAKYR---LGLTAT 145
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
292-511 |
1.44e-06 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 51.29 E-value: 1.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 292 IRELVRLCPkRRQTMLFSATMTEEV-DELVK-LSMTKPMRLAAdpSTKRPaTLTeevVRIRRMREVNQEAVLLALCSKTF 369
Cdd:COG0514 157 LGELRERLP-NVPVLALTATATPRVrADIAEqLGLEDPRVFVG--SFDRP-NLR---LEVVPKPPDDKLAQLLDFLKEHP 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 370 TAKAIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATdVA-ARGLDIIGVQTVINYACP 448
Cdd:COG0514 230 GGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT-IAfGMGIDKPDVRFVIHYDLP 308
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225457931 449 RDLTSYVHRVGRTARAGREGYAVTFVTDNDRSLLKSIVKRAGSKLRSRIVAEQsiiKWSHMIE 511
Cdd:COG0514 309 KSIEAYYQEIGRAGRDGLPAEALLLYGPEDVAIQRFFIEQSPPDEERKRVERA---KLDAMLA 368
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
169-460 |
1.93e-06 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 51.46 E-value: 1.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 169 AITGSGKTAAFSLPTLERLlFR--------PKRVQAIRVLVLTPT--------RELAVQVHSMMEKLAQFTDIRCCLIVG 232
Cdd:PRK09751 3 APTGSGKTLAAFLYALDRL-FReggedtreAHKRKTSRILYISPIkalgtdvqRNLQIPLKGIADERRRRGETEVNLRVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 233 GLS--SKMQETA--LRSMPDVVVATPGRMIDHLRNSMSVDLEDLAVLILDE------ADRLLELGFNAEirELVRLCPKR 302
Cdd:PRK09751 82 IRTgdTPAQERSklTRNPPDILITTPESLYLMLTSRARETLRGVETVIIDEvhavagSKRGAHLALSLE--RLDALLHTS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 303 RQTMLFSATMTEEVDELVKLSMTKPMRLAADPSTKRP--------------------------------------ATLTE 344
Cdd:PRK09751 160 AQRIGLSATVRSASDVAAFLGGDRPVTVVNPPAMRHPqirivvpvanmddvssvasgtgedshagregsiwpyieTGILD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 345 EVVRiRRMREV--NQEAVLLALCSKTFTAKAIIFSGTKQAAHRLKILFGLAG-----------FKAAELHGNLTQVQRLD 411
Cdd:PRK09751 240 EVLR-HRSTIVftNSRGLAEKLTARLNELYAARLQRSPSIAVDAAHFESTSGatsnrvqssdvFIARSHHGSVSKEQRAI 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 225457931 412 ALELFRKQQVDFLIATDVAARGLDIIGVQTVINYACPRDLTSYVHRVGR 460
Cdd:PRK09751 319 TEQALKSGELRCVVATSSLELGIDMGAVDLVIQVATPLSVASGLQRIGR 367
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
404-479 |
2.22e-06 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 51.27 E-value: 2.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 404 LTQVQRLDALELFRKQQVDFLIATDVAARGLDIIGVQTVINY-ACP---RdltsYVHRVGRTARaGREGYAVTFVTDNDR 479
Cdd:COG1111 395 LTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYePVPseiR----SIQRKGRTGR-KREGRVVVLIAKGTR 469
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
373-468 |
2.95e-06 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 47.20 E-value: 2.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 373 AIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLDIIGVQTVINYACPRDLT 452
Cdd:cd18794 33 GIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSME 112
|
90
....*....|....*.
gi 225457931 453 SYVHRVGrtaRAGREG 468
Cdd:cd18794 113 SYYQESG---RAGRDG 125
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
162-254 |
1.01e-05 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 46.42 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 162 GRDICGSAITGSGKTAAFSLPTLERLLFRPKrvQAIRVLVLTPTRELAVQVHSMMEKLAQ--FTDIRCCLIVGGLSSKMQ 239
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPE--KGVQVLYISPLKALINDQERRLEEPLDeiDLEIPVAVRHGDTSQSEK 78
|
90
....*....|....*
gi 225457931 240 ETALRSMPDVVVATP 254
Cdd:cd17922 79 AKQLKNPPGILITTP 93
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
171-282 |
2.95e-05 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 47.42 E-value: 2.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 171 TGSGKTAAFSLPTLERLLFRPKrvqaiRVLVLTPTRELAVQVHSMMEKLAQFTDIRCCLIVGGLSSKMQEtALRSMPDVV 250
Cdd:COG1111 26 TGLGKTAVALLVIAERLHKKGG-----KVLFLAPTKPLVEQHAEFFKEALNIPEDEIVVFTGEVSPEKRK-ELWEKARII 99
|
90 100 110
....*....|....*....|....*....|..
gi 225457931 251 VATPGRMIDHLRNSMsVDLEDLAVLILDEADR 282
Cdd:COG1111 100 VATPQVIENDLIAGR-IDLDDVSLLIFDEAHR 130
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
404-479 |
3.63e-05 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 47.18 E-value: 3.63e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 225457931 404 LTQVQRLDALELFRKQQVDFLIATDVAARGLDIIGVQTVINY-ACPRDLTSyVHRVGRTARaGREGYAVTFVTDNDR 479
Cdd:PRK13766 407 MSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYePVPSEIRS-IQRKGRTGR-QEEGRVVVLIAKGTR 481
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
147-279 |
4.06e-05 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 45.16 E-value: 4.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 147 KPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTLERLLFRPKRVQAIRVLVLTPTRELAVQvhsmmEKLAQFTDIR 226
Cdd:cd18036 2 ELRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEKRRSAGEKGRVVVLVNKVPLVEQ-----QLEKFFKYFR 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225457931 227 CCLIVGGLS------SKMQETALRSmpDVVVATPGRMIDHLRN---SMSVDLEDLAVLILDE 279
Cdd:cd18036 77 KGYKVTGLSgdsshkVSFGQIVKAS--DVIICTPQILINNLLSgreEERVYLSDFSLLIFDE 136
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
159-299 |
5.34e-05 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 44.73 E-value: 5.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 159 ALTGRDICGSAITGSGKTAAfSLPTLERLLFRPKRVQAIRVLVLTPTRELAVQvhsMMEKLAQFTDiRCCLIVGGLSSKM 238
Cdd:cd17927 14 ALKGKNTIICLPTGSGKTFV-AVLICEHHLKKFPAGRKGKVVFLANKVPLVEQ---QKEVFRKHFE-RPGYKVTGLSGDT 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 225457931 239 QETAlrSMP------DVVVATPGRMIDHLRNSMSVDLEDLAVLILDEADRLLElgfNAEIRELVRLC 299
Cdd:cd17927 89 SENV--SVEqivessDVIIVTPQILVNDLKSGTIVSLSDFSLLVFDECHNTTK---NHPYNEIMFRY 150
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
141-327 |
1.13e-04 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 43.68 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 141 EALGYTKPTPIQAACIPIALTGRDICGSAITGSGKTAAFSLPTlerLLFRPKrvqairVLVLTPTRELavqVHSMMEKLA 220
Cdd:cd17920 6 EVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPA---LLLDGV------TLVVSPLISL---MQDQVDRLQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 221 QfTDIRCCLIVGGLSSKMQETALRSMP----DVVVATP-----GRMIDHLRNSMSVDLedLAVLILDEADRLLELGFN-- 289
Cdd:cd17920 74 Q-LGIRAAALNSTLSPEEKREVLLRIKngqyKLLYVTPerllsPDFLELLQRLPERKR--LALIVVDEAHCVSQWGHDfr 150
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 225457931 290 ---AEIRELVRLCPkRRQTMLFSATMTEEV-DELVK-LSMTKP 327
Cdd:cd17920 151 pdyLRLGRLRRALP-GVPILALTATATPEVrEDILKrLGLRNP 192
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
404-471 |
1.30e-04 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 42.73 E-value: 1.30e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225457931 404 LTQVQRLDALELFRKQQVDFLIATDVAARGLDIIGVQTVINYACPRDLTSYVHRVGRTARaGREGYAV 471
Cdd:cd18801 74 MSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR-KRQGRVV 140
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
372-445 |
8.10e-04 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 42.90 E-value: 8.10e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225457931 372 KAIIFSGTKQAAHRLKILFGLAGFKAAELHGNLTQVQRLDALELFRKQQ--VDFLIATDVAARGLDIIGVQTVINY 445
Cdd:COG0553 551 KVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPeaPVFLISLKAGGEGLNLTAADHVIHY 626
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
171-282 |
9.92e-04 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 42.55 E-value: 9.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 171 TGSGKTAAFSLPTLERLLFRPKRVqairvLVLTPTRELAVQvHSmmEKLAQFTDIRCCLIVG--GLSSKMQETALRSMPD 248
Cdd:PRK13766 38 TGLGKTAIALLVIAERLHKKGGKV-----LILAPTKPLVEQ-HA--EFFRKFLNIPEEKIVVftGEVSPEKRAELWEKAK 109
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 225457931 249 VVVATP---------GRmidhlrnsmsVDLEDLAVLILDEADR 282
Cdd:PRK13766 110 VIVATPqviendliaGR----------ISLEDVSLLIFDEAHR 142
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
171-282 |
2.69e-03 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 39.42 E-value: 2.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 171 TGSGKTAAFSLPTLERLlfrpkRVQAIRVLVLTPTRELAVQVHSMMEKLAQFTDiRCCLIVGGLSSKMQETALRSmPDVV 250
Cdd:cd18035 25 TGLGKTIIAILVAADRL-----TKKGGKVLILAPSRPLVEQHAENLKRVLNIPD-KITSLTGEVKPEERAERWDA-SKII 97
|
90 100 110
....*....|....*....|....*....|..
gi 225457931 251 VATPGRMIDHLRNSmSVDLEDLAVLILDEADR 282
Cdd:cd18035 98 VATPQVIENDLLAG-RITLDDVSLLIFDEAHH 128
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
168-291 |
3.39e-03 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 39.23 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 168 SAITGSGKTAaFSLPTLerlLFRPKRVQaiRVLVLTPTRELAVQVHSMMEKLAQFTDIRCCLIV--GGLSSKMQETALRS 245
Cdd:cd17924 38 IAPTGVGKTT-FGLATS---LYLASKGK--RSYLIFPTKSLVKQAYERLSKYAEKAGVEVKILVyhSRLKKKEKEELLEK 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 225457931 246 MP----DVVVATPGRMIDHLRNSMSvdlEDLAVLILDEADRLLELGFNAE 291
Cdd:cd17924 112 IEkgdfDILVTTNQFLSKNFDLLSN---KKFDFVFVDDVDAVLKSSKNID 158
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
372-468 |
5.25e-03 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 38.00 E-value: 5.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 372 KAIIFSGTKQAAHRLKILFGLAGfkaaeLHGNLTQVQRLDALELFRKQQVDFLIATDVAARGLDI----IGVQTVINYAC 447
Cdd:cd18789 51 KIIVFTDNVEALYRYAKRLLKPF-----ITGETPQSEREEILQNFREGEYNTLVVSKVGDEGIDLpeanVAIQISGHGGS 125
|
90 100
....*....|....*....|.
gi 225457931 448 PRDltsYVHRVGRTARAGREG 468
Cdd:cd18789 126 RRQ---EAQRLGRILRPKKGG 143
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
147-311 |
6.81e-03 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 38.17 E-value: 6.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 147 KPTPIQAACI---------PIALTgRDICGSaiTGSGKTAAFSLPTLErLLFRPKRVqairvLVLTPTRELAVQVHSMME 217
Cdd:cd17918 15 SLTKDQAQAIkdiekdlhsPEPMD-RLLSGD--VGSGKTLVALGAALL-AYKNGKQV-----AILVPTEILAHQHYEEAR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225457931 218 KLaqFTDIRCCLIVGGLSSKMQetalrSMPDVVVATpgrmidHLRNSMSVDLEDLAVLILDEADRllelgFNAEIRElvR 297
Cdd:cd17918 86 KF--LPFINVELVTGGTKAQIL-----SGISLLVGT------HALLHLDVKFKNLDLVIVDEQHR-----FGVAQRE--A 145
|
170
....*....|....*
gi 225457931 298 LCPKRRQTML-FSAT 311
Cdd:cd17918 146 LYNLGATHFLeATAT 160
|
|
| |
