|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
26-1252 |
0e+00 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 1736.70 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 26 CVWYGECGIATGDKRYNCKYSGPPKPLPKDGYDLVQELCpGLFFDNVS--LCCDIQQLQTLKSNLQLPLQFLSRCPSCFY 103
Cdd:TIGR00917 1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVRCPACLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 104 NLMTLFCELTCSPHQSQFLNVTATEDYfdpktpENKTNVKELEYYVGQSFANAMYNACRDVEAPSSNEKALGLLCGRDAR 183
Cdd:TIGR00917 80 NFLNLFCELTCSPDQSLFINVTSTTKV------KTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 184 ACNATNWIEYMFNKDNGQAPFTIIPVFSDLSIL-GMEPMRNATKGCNESVDEVTGPCSCQDCSIVCGPKPQPPPPPMPWR 262
Cdd:TIGR00917 154 FKEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVSsGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 263 IWGLDAMYVIMWVTYVAFLFVFFG--ALLAVWCHRRRYFVSEYTPIDSNIAFSVNSSDKGEASCCDPLGAAFDDCLRRMF 340
Cdd:TIGR00917 234 KLGVKCVDFILAILYIVLVSVFLGggLLHPVRGKKKTSQMGTLSEADGEINSVNQQKDQNTPQRNWGQLSTVQGHLARFF 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 341 TKWGAFCVRNPTCIIFFSLAFITVCSSGLVFVQVTTNPVELWSAPHSQARLEKEYFDKHFGPFFRTEQLIIQAPNTSvhi 420
Cdd:TIGR00917 314 GKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTS--- 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 421 yepypagADVPFGPPLNKEILHQVLNLQIAIESITASYNNETVTLQDICVAPLSPYNknCTIMSVLNYFQNSHAVLDSQV 500
Cdd:TIGR00917 391 -------SHEKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIYSTCKKLQNMYSKLKPEN 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 501 GDDFYIyADYHTHFLYCVRAPAslndtsllhgPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTERLQR 580
Cdd:TIGR00917 462 YDDYGG-VDYVKYCFEHFTSPE----------SCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVTFPVNNFVNKTNKTEK 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 581 AWAWEKEFISFVKNYKNPNL--TISFTAERSIEDELNRESNSDVFTVIISYVVMFLYISLALGHIQSCSRLLVDSKISLG 658
Cdd:TIGR00917 531 AVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLG 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 659 IAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERLQ---------EETLDQQLGRIL 729
Cdd:TIGR00917 611 LSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYrqvgvdneqELTLERRLSRAL 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 730 GEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCVRGADDGQ 809
Cdd:TIGR00917 691 MEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSI 770
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 810 G-----SHASESYLFRFFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDSYVIANFKSLAQYL 884
Cdd:TIGR00917 771 SaekgsGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLL 850
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 885 HSGPPVYFVLEEGYNYSSRKGQNMVCGGMGCDNDSLVQQifnaaeLDTYTRVGFAPSSWIDDYFDWVSPQSSCCRLYNVT 964
Cdd:TIGR00917 851 EVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTN 924
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 965 HQFCNasVMDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPNPKCGKGGHAAYGSAVNIVGDDTYIGATYFMTYHTI 1044
Cdd:TIGR00917 925 GTFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQGYATIIQASSFRTYHTP 1002
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1045 LKTSADYTDAMKKARLIASNITEtmrskGSDYRVFPYSVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLGCELWSA 1124
Cdd:TIGR00917 1003 LNTQVDFINAMRAAQEFAAKVSR-----SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSV 1077
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1125 VIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITL 1204
Cdd:TIGR00917 1078 VNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITL 1157
|
1210 1220 1230 1240
....*....|....*....|....*....|....*....|....*...
gi 2251242 1205 TKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIG 1252
Cdd:TIGR00917 1158 TKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
|
|
| NPC1_N |
pfam16414 |
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ... |
24-248 |
1.61e-92 |
|
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.
Pssm-ID: 465110 Cd Length: 239 Bit Score: 297.59 E-value: 1.61e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 24 QSCVWYGECGIAT-GDKRYNCKYSGPPKPLPKDGYDLVQELCPGLFFDNVSLCCDIQQLQTLKSNLQLPLQFLSRCPSCF 102
Cdd:pfam16414 1 GRCAWYGECGKKSlFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSRCPACK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 103 YNLMTLFCELTCSPHQSQFLNVTATEdyfdpKTPENKTNVKELEYYVGQSFANAMYNACRDVEAPSSNEKALGLLCGrda 182
Cdd:pfam16414 81 KNFANLFCEFTCSPNQSTFLNVTKTK-----KSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICG--- 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2251242 183 RACNATNWIEYMFNKDNGQAPFTIIPVFSDLSI-LGMEPMRNATKGCNESVDEvTGPCSCQDCSIVC 248
Cdd:pfam16414 153 GACNYTRWLKFMGDKKNGGSPFQINFPDPPEEDpSGMVPLNPNTKDCNESYDA-SYACSCVDCPLSC 218
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
482-1249 |
1.65e-69 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 250.35 E-value: 1.65e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 482 IMSVLNYFQNSHAVldsQVGDDFYIYADYHTHFLYC---VRAPASLNDTSLLHG-------PCLGTFGGPVFPWLVLGG- 550
Cdd:pfam02460 67 IYQLNDYISTNVEI---QVDGIIISFKDLCSRYCDLncpVNKHYNGMLLSRRHNtridityPIMPVLGTPIYLGPHFGGv 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 551 --YDDQNYNNATALVITFPVNnyYNDTERLQRAWAWEKEFISFVKN-YKNPNLTISFTAERSIEDELNRESNSDVFTVII 627
Cdd:pfam02460 144 dfEPPGNISYAKAIVLWYFLK--FDEEEVEEDSKEWEDELSQLLHNkYASEHIQFTIFHDQILNDELVRNALTLTPFFVI 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 628 SYVVMFLYISLALGHIQSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIeVIPFLVLAVGVDNIFILV 707
Cdd:pfam02460 222 GFFLLLTFSIIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVC-VTPFLVLAIGVDDMFLMV 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 708 QTYQRDERlqEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLD 787
Cdd:pfam02460 301 AAWQRTTA--TLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAIC 378
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 788 IKRQ-EKNHLDILC-------CVRGADDGQGSHASESYLFRFFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDI 859
Cdd:pfam02460 379 AKPEaEGRHCLFVWatsspqrIDSEGSEPDKSHNIEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKE 458
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 860 GLDQSLSMPNDSYVIANFKSLAQYL-HSGPPVYFVLEEGYNYS---SRKGQNmvcggmgcdndslvqQIFNAAELDTYTR 935
Cdd:pfam02460 459 GLEPDKLVLEDSPLVEYLSLREKHFwPEGLQIQVAVNNPPNLTipeSRDRMN---------------EMVDEFENTPYSL 523
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 936 VGFAPSSWIDDYFDWVSPQssccrlynvthqfcNASVMD----PTCVRCRPLTPEGKQRPQGKEFMKFlpmflsdnpnpk 1011
Cdd:pfam02460 524 GPNSTLFWLREYENFLSTL--------------NMEEEEdeekEWSYGNLPSFLKAPGNSHWAGDLVW------------ 577
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1012 cgkgghaaygsavnivGDDTYIGATY-FMTYHTILKTSADYTDAMKKARLIAsnitetmrSKGSDYRVFPYSVFYVFYEQ 1090
Cdd:pfam02460 578 ----------------DDNTTMVTKFrFTLAGKGLSTWNDRTRALQEWRSIA--------DQYPEFNVTVFDEDAPFADQ 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1091 YLTIIDDTIFNLSVSLGSIFLVTLVVLGcELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSH 1170
Cdd:pfam02460 634 YLTILPSTIQNIVITLICMFIVCFLFIP-NPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAH 712
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2251242 1171 ITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITLTkFGGIVVLAFAKSQIFEIFYFRMYLaMVLLGATHGLIFLPVLLS 1249
Cdd:pfam02460 713 IAYHFVRSRGDTPAERVVDALEALGWPVFQGGLST-ILGVLVLLFVPSYMVVVFFKTVFL-VVAIGLLHGLFILPIILS 789
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
650-804 |
2.83e-61 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 206.28 E-value: 2.83e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 650 LVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERlqEETLDQQLGRIL 729
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPR--SLDVSERIAEAL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2251242 730 GEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCVRG 804
Cdd:pfam12349 79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
583-1253 |
5.87e-59 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 222.45 E-value: 5.87e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 583 AWEKEFISFVKNY--KNPNLTISFTAERSIEDELNRESNSDVFTVIISYVVMFLYislalghiqSCSRLL----VDSKIS 656
Cdd:TIGR00918 358 AWQRNFSEEVQQSlpKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAY---------ACLTMLrwdcAKSQGS 428
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 657 LGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQrdERLQEETLDQQLGRILGEVAPTM 736
Cdd:TIGR00918 429 VGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFS--ETGQNIPFEERTGECLKRTGASV 506
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 737 FLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCV-------------- 802
Cdd:TIGR00918 507 VLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFfspcsarviqiepq 586
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 803 --------------------------RGAD-------------------------DGQGS-------------HASESYL 818
Cdd:TIGR00918 587 ayadgsappvysshmqstvqlrteydPGTQhyyttneprshlsvqpsdplscqspDIAGStrdllsqfedskaACLSLPC 666
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 819 FR-----FFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDS----YVIANFKSLAQYlhsgpP 889
Cdd:TIGR00918 667 ARwtlatFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTnehdFLDAQFRYFSFY-----N 741
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 890 VYFVLEEGYNYSSRKgqnmvcggmgcdndslvQQIFNAAelDTYTRV--------GFAPSSWIDDYFDWVSP-QSSCCRL 960
Cdd:TIGR00918 742 MYAVTQGNFDYPTQQ-----------------QLLYDLH--QSFSSVkyvlkednGQLPRMWLHYFRDWLQGlQKAFDED 802
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 961 YN----VTHQFCNAS--------VMDPTCVRCRPLTPE--GKQRPQGKE-------FMKFLPMFLSDNPnpkcgkgghAA 1019
Cdd:TIGR00918 803 WRdgriTKENYRNGSddavlaykLLVQTGHRDKPVDKEqlTTQRLVNADgiinpnaFYIYLSAWVSNDP---------VA 873
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1020 YG-SAVNI-------VGDDT-YIGATY------------FMTYHTILKTSADYTDAMKKARLIASNITetmrskGSDYRV 1078
Cdd:TIGR00918 874 YAaSQANIyphppewLHDKNdYDPENLripaaepleyaqFPFYLNGLRETSQFVEAIEHVRAICNNYE------GFGLPS 947
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1079 FPYSVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLgCELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLV 1158
Cdd:TIGR00918 948 YPSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLL-LNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILI 1026
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1159 MSCGISVEFCSHITRAFtMSTKGSRVSRAEEALAHMGSSVFSGITLTKFGgivVLAFAKSQI-FEIFYFRMYLAMV-LLG 1236
Cdd:TIGR00918 1027 ASVGIGVEFTVHIALGF-LTAIGDRNRRAVLALEHMFAPVLDGALSTLLG---VLMLAGSEFdFIVRYFFAVLAVLtCLG 1102
|
810
....*....|....*..
gi 2251242 1237 ATHGLIFLPVLLSYIGP 1253
Cdd:TIGR00918 1103 VLNGLVLLPVLLSMFGP 1119
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
337-1259 |
9.04e-35 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 143.46 E-value: 9.04e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 337 RRMFTKWGAFCVRNPTCIIFFSLAFITVCSSGLVFVQVTTNPVElWSAPHSQARLEKEYFDKHFGPffrTEQLIIqapnt 416
Cdd:COG1033 1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVV----- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 417 svhIYEPYPagaDVpfgppLNKEILHQVLNLQIAIESItasynnETVTlqdicvaplspynkncTIMSVLNyFQNSHAVL 496
Cdd:COG1033 72 ---AVEGKD---DI-----FTPETLEALRELTEELEEI------PGVD----------------SVTSLTN-VRATEGTE 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 497 DSQVGDDFyIYADYHThflycvrAPASLND--TSLLHGPclgtfggpvfpwlvlgGYDDQNYNN---ATALVITFPVNNY 571
Cdd:COG1033 118 DGLTVEPL-IPDELPA-------SPEELAElrEKVLSSP----------------LYVGRLVSPdgkATLIVVTLDPDPL 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 572 YNDTERLQRAwaweKEFISFVKNYKNPNLTISFTAERSIEDELNRESNSDVFTVI-ISYVVMFLYISLALGHIqscsrll 650
Cdd:COG1033 174 SSDLDRKEVV----AEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFpLALLLILLLLFLFFRSL------- 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 651 vdskiSLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIeVIPFLVLAVGVDNIFILVQTYqRDERLQEETLDQQLGRILG 730
Cdd:COG1033 243 -----RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYGIHLLNRY-REERRKGLDKREALREALR 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 731 EVAPTMFLSSFseTSAFFFGAL--SSMPAVHTFSLFAGMAVLIDFLLQITCFVSLL-GLDIKRqeknhldilccvrgadD 807
Cdd:COG1033 316 KLGPPVLLTSL--TTAIGFLSLlfSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLsLLPRPK----------------P 377
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 808 GQGSHASESYLFRFFKNyFAPLLLKdwLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDSYVIANFKSLAQYLHSG 887
Cdd:COG1033 378 KTRRLKKPPELGRLLAK-LARFVLR--RPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGS 454
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 888 PPVYFVLEEGYNYssrkgqnmvcggmGCDNDSLVQQIFN-AAELDTYTRVGFAPSswIDDYFDWVSpqssccRLYNvthq 966
Cdd:COG1033 455 DPLEVVVDTGEPD-------------GLKDPEVLKEIDRlQDYLESLPEVGKVLS--LADLVKELN------QALN---- 509
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 967 fcnasvmdptcvrcrPLTPEGKQRPQGKEFMKFLPMFLSDNPnpkcgkgghaayGSAVN--IVGDDTYIGATYFMTYHti 1044
Cdd:COG1033 510 ---------------EGDPKYYALPESRELLAQLLLLLSSPP------------GDDLSrfVDEDYSAARVTVRLKDL-- 560
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1045 lktSADYTDAMKKArlIASNITETMRSKGSDYRVfpYSVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLGcELWSA 1124
Cdd:COG1033 561 ---DSEEIKALVEE--VRAFLAENFPPDGVEVTL--TGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFR-SLRLG 632
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1125 VIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFT--MSTKGSRVSRAEEALAHMGSSV-FSG 1201
Cdd:COG1033 633 LISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAIlFTS 712
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 2251242 1202 ITLtkFGGIVVLAFAKSQIfeIFYFRMYLAMVLLGATHG-LIFLPVLLSYIGPSVNKAK 1259
Cdd:COG1033 713 LTL--AAGFGVLLFSSFPP--LADFGLLLALGLLVALLAaLLLLPALLLLLDPRIAKKR 767
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
336-784 |
2.11e-12 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 71.81 E-value: 2.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 336 LRRMFTKWGAFCVRNPTCIIFFSLAFITVCSSGLVFVQVTTNPVElWSAPHSQARLEKEYFDKHFGPFfrteqliiqapn 415
Cdd:COG1033 388 LGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFED-YLPEDSPIRQDLDFIEENFGGS------------ 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 416 TSVHIYepypagadVPFGPP---LNKEILHQVLNLQIAIESItasynnETVTlqdicvaplspynkncTIMSVLNYFQNS 492
Cdd:COG1033 455 DPLEVV--------VDTGEPdglKDPEVLKEIDRLQDYLESL------PEVG----------------KVLSLADLVKEL 504
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 493 HAVLDSQVGDDFYIyadyhthflycvraPASLNDTSLLHGPCLGTFGGpvfpwlVLGGYDDQNYNNAtalVITFPVNNyy 572
Cdd:COG1033 505 NQALNEGDPKYYAL--------------PESRELLAQLLLLLSSPPGD------DLSRFVDEDYSAA---RVTVRLKD-- 559
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 573 NDTERLQRAWAWEKEFISfvKNYKNPNLTISFTAERSIEDELNRE-SNSDVFTVIISYVVMFLYISLALGhiqscsrllv 651
Cdd:COG1033 560 LDSEEIKALVEEVRAFLA--ENFPPDGVEVTLTGSAVLFAAINESvIESQIRSLLLALLLIFLLLLLAFR---------- 627
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 652 dsKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPfLVLAVGVDN-IFILvqTYQRDERLQEETLDQQLGRILG 730
Cdd:COG1033 628 --SLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYtIHFL--SRYREERRKGGDLEEAIRRALR 702
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 2251242 731 EVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLL 784
Cdd:COG1033 703 TTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALL 756
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
1047-1263 |
2.99e-10 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 64.88 E-value: 2.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1047 TSADYTDAMKKARliasNITETMRSKGSDYRVFpySVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLGCeLWSAVI 1126
Cdd:COG1033 175 SDLDRKEVVAEIR----AIIAKYEDPGVEVYLT--GFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRS-LRGVLL 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1127 MCITIAMILVNMFGVMWLWGISLNAVS--LVNLVMscGISVEFCSHITRAFT--MSTKGSRVSRAEEALAHMGSSVFSGi 1202
Cdd:COG1033 248 PLLVVLLAVIWTLGLMGLLGIPLSPLTilVPPLLL--AIGIDYGIHLLNRYReeRRKGLDKREALREALRKLGPPVLLT- 324
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2251242 1203 TLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHgLIFLPVLLSYIGPSVNKAKRHTT 1263
Cdd:COG1033 325 SLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS-LTLLPALLSLLPRPKPKTRRLKK 384
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
572-800 |
7.77e-08 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 56.77 E-value: 7.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 572 YNDTERlqrawawEKEFISFVKNYK---NPNLTISFTAERSIEDELNResnsdvfTVIISYVVMFLYIslalghiqscsr 648
Cdd:TIGR00921 157 YNDVER-------SLERTNPPSGKFldvTGSPAINYDIEREFGKDMGT-------TMAISGILVVLVL------------ 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 649 LLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPfLVLAVGVDNIfILVQTYQRDERLQEETLDQQLGRI 728
Cdd:TIGR00921 211 LLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVP-MLIGVGIDYG-IQTLNRYEEERDIGRAKGEAIVTA 288
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2251242 729 LGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGL-DIKRQEKNHLDILC 800
Cdd:TIGR00921 289 VRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSiDIGREKVKKEIIAI 361
|
|
| 2A060605 |
TIGR00920 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ... |
612-793 |
1.19e-07 |
|
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273339 [Multi-domain] Cd Length: 886 Bit Score: 56.40 E-value: 1.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 612 DELNRESNS-DVFTVIISYVVMFLYIslalgHIQSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIViEV 690
Cdd:TIGR00920 51 PKFEEEYLSsDVIVMTITRCIAVLYI-----YYQFCNLRQLGSKYILGIAGLFTIFSSFVFSTAVIHFLGSELTGLN-EA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 691 IPFLVLAVGVDNIFILVQtYQRDERLQEETLDqQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVL 770
Cdd:TIGR00920 125 LPFFLLLIDLSKASALAK-FALSSNSQDEVRD-NIARGMAILGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVL 202
|
170 180
....*....|....*....|....*.
gi 2251242 771 IDFLLQITCF---VSLLgLDIKRQEK 793
Cdd:TIGR00920 203 ANYFVFMTFFpacLSLV-LELSRSGR 227
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
598-786 |
3.06e-07 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 54.84 E-value: 3.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 598 PNLTISFTAERSIEDELNRESNSDVFTVIISYVVMFLYISLAlghiqscsrllVDSKISLGIAGILIVLSSVACSLGIFS 677
Cdd:TIGR00921 545 PGVKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLA-----------VFRNPIKAVFPLIAIGSGILWAIGLMG 613
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 678 YMGMPLTLIVIEVIPfLVLAVGVDNIFILVQTY--QRDERLQEETLDQQLGRilgeVAPTMFLSSFseTSAFFFGAL--S 753
Cdd:TIGR00921 614 LRGIPSFLAMATTIS-IILGLGMDYSIHLAERYfeERKEHGPKEAITHTMER----TGPGILFSGL--TTAGGFLSLllS 686
|
170 180 190
....*....|....*....|....*....|...
gi 2251242 754 SMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGL 786
Cdd:TIGR00921 687 HFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
1095-1278 |
6.00e-07 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 53.95 E-value: 6.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1095 IDDTIFNLSVSLGSIFLVTLVVLGcELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISV-------Ef 1167
Cdd:COG0841 330 IEEVVKTLLEAILLVVLVVFLFLR-SWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVddaivvvE- 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1168 csHITRafTMSTKGSRVSRAEEALAHMGSSVFSgITLTKfggIVV---LAFAKSQIFEIFYfrmYLAMVLLGAT-----H 1239
Cdd:COG0841 408 --NIER--HMEEGLSPLEAAIKGAREVAGAVIA-STLTL---VAVflpLAFMGGITGQLFR---QFALTVAIALlislfV 476
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2251242 1240 GLIFLPVLLSYIGPSVNKAKRHTTYERY-RGTER-----ERLLNF 1278
Cdd:COG0841 477 ALTLTPALCARLLKPHPKGKKGRFFRAFnRGFDRltrgyGRLLRW 521
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
659-786 |
9.33e-07 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 52.29 E-value: 9.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 659 IAGILIVLS---SVACSLGI------FSYMGMPLTLIVIEVIpfLVLAVGVD-NIFiLVQTYqRDERLQEETLDQQLGRI 728
Cdd:pfam03176 167 VAALLPLLTvglSLGAAQGLvailahILGIGLSTFALNLLVV--LLIAVGTDyALF-LVSRY-REELRAGEDREEAVIRA 242
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 729 LGEVAPTMFLSSFseTSAFFFGAL--SSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGL 786
Cdd:pfam03176 243 VRGTGKVVTAAGL--TVAIAMLALsfARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
627-776 |
4.99e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 47.92 E-value: 4.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 627 ISYVVMFLYISLALGhiqscsrllvdsKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIeVIPFLVLAVGVD-NIFI 705
Cdd:COG4258 647 LALLLILLLLLLRLR------------SLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHL-IALLLVLGIGIDyALFF 713
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2251242 706 LVQTYQRDERLqeETLdqqlgrilgevaPTMFLSSFseTSAFFFG--ALSSMPAVHTFSLF----AGMAVLIDFLLQ 776
Cdd:COG4258 714 TEGLLDKGELA--RTL------------LSILLAAL--TTLLGFGllAFSSTPALRSFGLTvllgILLALLLAPLLA 774
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
1095-1215 |
5.02e-05 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 47.72 E-value: 5.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1095 IDDTIFNLSVSL--GSIfLVTLVV---LGcELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCG------- 1162
Cdd:COG3696 330 IDRAIHTVTKNLleGAL-LVILVLflfLG-NLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDFGiivdgav 407
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 2251242 1163 ISVEFC-SHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITltkfggIVVLAF 1215
Cdd:COG3696 408 VMVENIlRRLEENRAAGTPRERLEVVLEAAREVRRPIFFATL------IIILVF 455
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
1079-1251 |
5.13e-05 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 47.67 E-value: 5.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1079 FPYSVFY-VFYEQYLTI---IDDTIFNLSVSLGSIFLVTLVVLGcELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSL 1154
Cdd:pfam00873 310 FPQGVEIvVVYDTTPFIrasIEEVVKTLLEAIVLVILVMFLFLQ-NWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTL 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1155 VNLVMSCGISV-------EFCSHITRAFTMSTKgsrvsraEEALAHMGSSVFSGItltkFGGIVVLAFaksqifeifyfr 1227
Cdd:pfam00873 389 GGLVLAIGLVVddaivvvENIERVLEENGLKPL-------EAAYKSMGEIGGALV----AIALVLSAV------------ 445
|
170 180
....*....|....*....|....
gi 2251242 1228 mYLAMVLLGATHGLIFLPVLLSYI 1251
Cdd:pfam00873 446 -FLPILFLGGLTGRIFRQFAITIV 468
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
1087-1262 |
4.07e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 44.84 E-value: 4.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1087 FYEQYLtiiDDTIFNLSVSLGSIFLVTLVVLGcELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVE 1166
Cdd:COG4258 633 LFGRYR---NDALWLLLLALLLILLLLLLRLR-SLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGID 708
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1167 FCSHITRAFTmstkgsrvsRAEEALAHMGSSVFSGI-TLTKFGgivVLAFAKSQIfeifyfrmyLA----MVLLGathgl 1241
Cdd:COG4258 709 YALFFTEGLL---------DKGELARTLLSILLAALtTLLGFG---LLAFSSTPA---------LRsfglTVLLG----- 762
|
170 180
....*....|....*....|.
gi 2251242 1242 IFLPVLLSYIGPSVNKAKRHT 1262
Cdd:COG4258 763 ILLALLLAPLLAPRRRPRRAA 783
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
1086-1166 |
6.15e-04 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 44.24 E-value: 6.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1086 VFYEQYLTI---IDDTIFNLSVSLGSIFLVTLVVLGcELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCG 1162
Cdd:NF033617 317 VLYDRTRFIrasIDEVESTLLEAVALVILVVFLFLR-NLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIG 395
|
....
gi 2251242 1163 ISVE 1166
Cdd:NF033617 396 LVVD 399
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
1100-1251 |
9.58e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 43.67 E-value: 9.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2251242 1100 FNLSVSLGSIFLVTLVVLGCELWSAVIMCITIAMILVNM-FGVMWLWGISLNAVSLVNLVMSCGISVEFCSHI-TRAFTM 1177
Cdd:TIGR00921 195 MGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTlNRYEEE 274
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2251242 1178 STKGSRVSRA-EEALAHMGSSVFSGITLTKFGgivVLAFAKSQIFEIFYFRMYLAM-VLLGATHGLIFLPVLLSYI 1251
Cdd:TIGR00921 275 RDIGRAKGEAiVTAVRRTGRAVLIALLTTSAG---FAALALSEFPMVSEFGLGLVAgLITAYLLTLLVLPALLQSI 347
|
|
| |
