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Conserved domains on  [gi|224809397|ref|NP_001139255|]
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BLOC-1-related complex subunit 8 isoform 2 [Homo sapiens]

Protein Classification

BORCS8 domain-containing protein( domain architecture ID 10562761)

BORCS8 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BORCS8 pfam10167
BLOC-1-related complex sub-unit 8; This is the N-terminal 80 residues of a family of proteins ...
 8-109 2.36e-43

BLOC-1-related complex sub-unit 8; This is the N-terminal 80 residues of a family of proteins conserved from plants to humans. It contains a characteriztic NEP sequence motif. Family members include BORCS8 (BLOC-1-related complex sub-unit 8) also known as MEF2BNB. It constitutes sub-unit 8 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of lysosomes toward the cell periphery.


:

Pssm-ID: 462974  Cd Length: 107  Bit Score: 136.99  E-value: 2.36e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809397    8 LKGKKVTDKFTESVYVLANEPSVALYRLQEHVRRSLPELAQHKADMQRWEEQSQGAIYTVEYACSAVKNLVDSSVYFRSV 87
Cdd:pfam10167   1 DKVKKATEKISENIHIVANEPSLALYRLQEHVRKALPAIVELRKEVQQLQEQLQGHCYDVEYAISAVKSMKESESSFENI 80

                          90       100
                  ....*....|....*....|..
gi 224809397   88 EGLLKQAISIRDHMNASAQGHR 109
Cdd:pfam10167  81 QELLKNSIFLKQQLKYEESRIR 102
 
Name Accession Description Interval E-value
BORCS8 pfam10167
BLOC-1-related complex sub-unit 8; This is the N-terminal 80 residues of a family of proteins ...
 8-109 2.36e-43

BLOC-1-related complex sub-unit 8; This is the N-terminal 80 residues of a family of proteins conserved from plants to humans. It contains a characteriztic NEP sequence motif. Family members include BORCS8 (BLOC-1-related complex sub-unit 8) also known as MEF2BNB. It constitutes sub-unit 8 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of lysosomes toward the cell periphery.


Pssm-ID: 462974  Cd Length: 107  Bit Score: 136.99  E-value: 2.36e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809397    8 LKGKKVTDKFTESVYVLANEPSVALYRLQEHVRRSLPELAQHKADMQRWEEQSQGAIYTVEYACSAVKNLVDSSVYFRSV 87
Cdd:pfam10167   1 DKVKKATEKISENIHIVANEPSLALYRLQEHVRKALPAIVELRKEVQQLQEQLQGHCYDVEYAISAVKSMKESESSFENI 80

                          90       100
                  ....*....|....*....|..
gi 224809397   88 EGLLKQAISIRDHMNASAQGHR 109
Cdd:pfam10167  81 QELLKNSIFLKQQLKYEESRIR 102
 
Name Accession Description Interval E-value
BORCS8 pfam10167
BLOC-1-related complex sub-unit 8; This is the N-terminal 80 residues of a family of proteins ...
 8-109 2.36e-43

BLOC-1-related complex sub-unit 8; This is the N-terminal 80 residues of a family of proteins conserved from plants to humans. It contains a characteriztic NEP sequence motif. Family members include BORCS8 (BLOC-1-related complex sub-unit 8) also known as MEF2BNB. It constitutes sub-unit 8 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of lysosomes toward the cell periphery.


Pssm-ID: 462974  Cd Length: 107  Bit Score: 136.99  E-value: 2.36e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809397    8 LKGKKVTDKFTESVYVLANEPSVALYRLQEHVRRSLPELAQHKADMQRWEEQSQGAIYTVEYACSAVKNLVDSSVYFRSV 87
Cdd:pfam10167   1 DKVKKATEKISENIHIVANEPSLALYRLQEHVRKALPAIVELRKEVQQLQEQLQGHCYDVEYAISAVKSMKESESSFENI 80

                          90       100
                  ....*....|....*....|..
gi 224809397   88 EGLLKQAISIRDHMNASAQGHR 109
Cdd:pfam10167  81 QELLKNSIFLKQQLKYEESRIR 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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