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Conserved domains on  [gi|224611699|ref|NP_001139133|]
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endothelial transcription factor GATA-2 isoform 1 [Homo sapiens]

Protein Classification

GATA-type transcription factor( domain architecture ID 10078896)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0008270|GO:0043565
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 349-398 1.68e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.65  E-value: 1.68e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 224611699 349 CANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNVNRPLTMKKEG-IQTRNR 398
Cdd:cd00202    2 CSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 294-344 1.05e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.64  E-value: 1.05e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 224611699 294 ECVNCGATATPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 344
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 349-398 1.68e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.65  E-value: 1.68e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 224611699 349 CANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNVNRPLTMKKEG-IQTRNR 398
Cdd:cd00202    2 CSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 294-344 1.05e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.64  E-value: 1.05e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 224611699 294 ECVNCGATATPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 344
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
344-393 1.59e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 76.30  E-value: 1.59e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 224611699   344 RAGTCCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNV-NRPLTMKKEGI 393
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
290-338 2.82e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 67.06  E-value: 2.82e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 224611699   290 SEGRECVNCGATATPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 338
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 349-383 4.35e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.11  E-value: 4.35e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224611699  349 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLHNVN 383
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 295-329 1.86e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 61.18  E-value: 1.86e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224611699  295 CVNCGATATPLWRRDGTGHY-LCNACGLYHKMNGQN 329
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
297-398 5.77e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 58.34  E-value: 5.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224611699 297 NCGATATPLWRR-DGTGHYLCNACGLYHKMNGQNRPLikPKRRLSAARRAGTCCANCQTTTTTLWRRNANGdpvCNACGL 375
Cdd:COG5641  303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKILSPPTT---SNSPGA 377

                         90       100
                 ....*....|....*....|...
gi 224611699 376 YYKLHNVNRPLTMKKEGIQTRNR 398
Cdd:COG5641  378 QVKLPNQTRSTGATKKKITRRRM 400
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
295-373 1.32e-06

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 50.64  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224611699 295 CVNCGATATPLWRRD-----GTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTT-TTLWRRNANGDP 368
Cdd:COG5641  161 CSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTESIGNSSA 240


                 ....*
gi 224611699 369 VCNAC 373
Cdd:COG5641  241 SKLTK 245
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 349-398 1.68e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.65  E-value: 1.68e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 224611699 349 CANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNVNRPLTMKKEG-IQTRNR 398
Cdd:cd00202    2 CSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 294-344 1.05e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.64  E-value: 1.05e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 224611699 294 ECVNCGATATPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 344
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
344-393 1.59e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 76.30  E-value: 1.59e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 224611699   344 RAGTCCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNV-NRPLTMKKEGI 393
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
290-338 2.82e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 67.06  E-value: 2.82e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 224611699   290 SEGRECVNCGATATPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 338
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 349-383 4.35e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.11  E-value: 4.35e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224611699  349 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLHNVN 383
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 295-329 1.86e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 61.18  E-value: 1.86e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224611699  295 CVNCGATATPLWRRDGTGHY-LCNACGLYHKMNGQN 329
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
297-398 5.77e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 58.34  E-value: 5.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224611699 297 NCGATATPLWRR-DGTGHYLCNACGLYHKMNGQNRPLikPKRRLSAARRAGTCCANCQTTTTTLWRRNANGdpvCNACGL 375
Cdd:COG5641  303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKILSPPTT---SNSPGA 377

                         90       100
                 ....*....|....*....|...
gi 224611699 376 YYKLHNVNRPLTMKKEGIQTRNR 398
Cdd:COG5641  378 QVKLPNQTRSTGATKKKITRRRM 400
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
349-398 1.29e-08

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 57.19  E-value: 1.29e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 224611699 349 CANCQTTTTTLWRR-----NANGDPVCNACGLYYKLHNVNR-PLTMKKEGIQTRNR 398
Cdd:COG5641  161 CSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRSS 216
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
295-373 1.32e-06

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 50.64  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224611699 295 CVNCGATATPLWRRD-----GTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTT-TTLWRRNANGDP 368
Cdd:COG5641  161 CSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTESIGNSSA 240


                 ....*
gi 224611699 369 VCNAC 373
Cdd:COG5641  241 SKLTK 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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