BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   6 YYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSDAFSIILDFLYS 85
Cdd:cd18330    1 YYTKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSEAFSIILDFLYS 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 224591419  86 GKLDLCGENVIEVMSAASYLQMNDVVNFCKTYI 118
Cdd:cd18330   81 GKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113

C2H2-type zinc-finger domain;

                          10        20
                  ....*....|....*....|....*
gi 224591419  341 HKCPFCPYTAKQKGILKRHIRSHTG 365
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   6 YYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSDAFSIILDFLYS 85
Cdd:cd18330    1 YYTKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSEAFSIILDFLYS 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 224591419  86 GKLDLCGENVIEVMSAASYLQMNDVVNFCKTYI 118
Cdd:cd18330   81 GKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419    25 DCSIIVEGRIFKAHRNILFANSGYFRALLIHyIQDSGRHSTASLDIVTSDAFSIILDFLYSGKLDLCGENVIEVMSAASY 104
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSS-DFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 224591419   105 LQMNDVVNFCKTYIRSSL 122
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*
gi 224591419  356 LKRHIRSHTGERPYPCETCGKRFTR 380
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   6 YYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSDAFSIILDFLYS 85
Cdd:cd18330    1 YYTKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSEAFSIILDFLYS 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 224591419  86 GKLDLCGENVIEVMSAASYLQMNDVVNFCKTYI 118
Cdd:cd18330   81 GKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   5 SYYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSDAFSIILDFLY 84
Cdd:cd18329    3 SHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFSPDTFTIILDFVY 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 224591419  85 SGKLDLCGENVIEVMSAASYLQMNDVVNFCKTYI 118
Cdd:cd18329   83 SGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   5 SYYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTAS-LDIVTSDAFSIILDFL 83
Cdd:cd18201    3 SYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTTVThLDVVAVQGFSVILDFM 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 224591419  84 YSGKLDLCGENVIEVMSAASYLQMNDVVNFCKTYIRSSLD 123
Cdd:cd18201   83 YSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419  10 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRAllihYIQDSGrHSTASLD--IVTSDAFSIILDFLYSGK 87
Cdd:cd18217    5 LLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGA----QYKDTE-DNIVFLDqsQVSADGFQKLLEFIYTGN 79

                         90       100
                 ....*....|....*....|....*....
gi 224591419  88 LDLCGENVIEVMSAASYLQMNDVVNFCKT 116
Cdd:cd18217   80 LNLDSWNVAEIHQAASYLGMEEVVAKCKI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   1 MEMQSYYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRalLIHYIQDSGRHSTASL--DIVTSDAFSI 78
Cdd:cd18956    1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH--LFYRDRPAGGRDTVRLngDIVTAPAFGR 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 224591419  79 ILDFLYSGKLDLCGENVIEVMSAASYLQMNDVVNFCKTYIR 119
Cdd:cd18956   79 LLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLR 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   5 SYYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLI------HYIQDSGRHSTASLDIVTSDAFSI 78
Cdd:cd18228    1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVgqasprLVLVSPAGKCVLDLHHVTVTGFAP 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 224591419  79 ILDFLYSGKLDLCGENVIEVMSAASYLQMNDVVNFCKTYIRSSL 122
Cdd:cd18228   81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   1 MEMQSYYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRalLIHYIQDSGRHSTA-SLDIVTSDAFSII 79
Cdd:cd18323    1 MEFPDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH--MFYKEQLDKRDLVCiNNEIVTAPAFSLL 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 224591419  80 LDFLYSGKLDLCGENVIEVMSAASYLQMNDVVNFCK 115
Cdd:cd18323   79 LEFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   5 SYYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHyiqdsgrHSTASLD--IVTSDAFSIILDF 82
Cdd:cd18333    3 SHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVH-------DNLINLDheMVSPGIFRLILDY 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 224591419  83 LYSGKLDLCGE----NVIEVMSAASYLQMNDVVNFCKTYIRSS 121
Cdd:cd18333   76 IYTGRLSEGDPgseqNLGAVLAAASYLQIPDLVALCKKKLKRN 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   9 KLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHyiqdsgRHSTASLDIVTSDAFSIILDFLYSGKL 88
Cdd:cd18206    8 HVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVD------QKDVVHLDISNAAGLGQVLEFMYTAKL 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 224591419  89 DLCGENVIEVMSAASYLQMNDVVNFCKTYI 118
Cdd:cd18206   82 SLSPENVDDVLAVATFLQMQDIVTACHALK 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   1 MEMQSYYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRallIHYIQDSGRHSTASL--DIVTSDAFSI 78
Cdd:cd18325    1 MEFPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFH---LFYRDQLDKRDIVHLnsDIVTAPAFSL 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 224591419  79 ILDFLYSGKLDLCGENVIEVMSAASYLQMNDVVNFCK 115
Cdd:cd18325   78 LLEFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419  10 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALL-IHYIQDSGRHSTASLDIVTSDAFSIILDFLYSGKL 88
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLnYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQI 80

                         90       100
                 ....*....|....*....|....*.
gi 224591419  89 DLCGENVIEVMSAASYLQMNDVVNFC 114
Cdd:cd18245   81 KLSEDNIQDIVQAADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   8 AKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSgRHSTASLDIVTSDAFSIILDFLYSGK 87
Cdd:cd18255    3 VTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRES-SQDEIELKGVSAKGLKHILDFAYTSE 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 224591419  88 LDLCGENVIEVMSAASYLQMNDVVNFCKTYIRSSLDI 124
Cdd:cd18255   82 LTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSV 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   1 MEMQSYYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLihyiqdSGrHSTASLDI---VTSDAFS 77
Cdd:cd18289    7 IEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLF------SG-NSKSAFELpatVPPACFQ 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 224591419  78 IILDFLYSGKLDLCGENVIEVMSAASYLQMNDVV 111
Cdd:cd18289   80 QILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIV 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   6 YYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTA-SLDIVTSDAFSIILDFLY 84
Cdd:cd18196    4 HFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQlDSEVVTAEAFAALIDMMY 83

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 224591419  85 SGKLDLCGENVIEVMSAASYLQMNDVVNFCKTYIRS 120
Cdd:cd18196   84 TSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTT 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   1 MEMQSYYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLihyiqDSGrhSTASLD--IVTSDAFSI 78
Cdd:cd18225    1 MELPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLL-----DST--DTISIDasVVSPEEFAL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 224591419  79 ILDFLYSGKLDLCGENVIEVMSAASYLQMNDVVNFCKTYIRS 120
Cdd:cd18225   74 LLEMVYTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTS 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419  10 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHyiQDSGRHSTASLDI-VTSDAFSIILDFLYSGKL 88
Cdd:cd18331   11 VLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTD--QLKCNLSVINLDPeINPEGFNILLDFMYTSRL 88

                         90       100       110
                 ....*....|....*....|....*....|
gi 224591419  89 DLCGENVIEVMSAASYLQMNDVVNFCKTYI 118
Cdd:cd18331   89 NLREGNIMAVMATAMYLQMEHVVDTCRKFI 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419  18 RKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRhSTASLDIVTSDAFSIILDFLYSGKLDLCGENVIE 97
Cdd:cd18264   23 RAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKA-RVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLED 101

                         90       100
                 ....*....|....*....|....*.
gi 224591419  98 VMSAASYLQMNDVVNFCKTYIRSSLD 123
Cdd:cd18264  102 TLEAASYLQVTEAIGLCSQYLINNLA 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419  14 LNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHyiQDSGRHSTASLDIVTSDAFSIILDFLYSGKLDLCGE 93
Cdd:cd18278   22 LNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVG--QTENDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRE 99

                         90       100
                 ....*....|....*....|....*
gi 224591419  94 NVIEVMSAASYLQMNDVVNFCKTYI 118
Cdd:cd18278  100 NIQEVIRCAEFLRMHNLEDSCFRFL 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419  14 LNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIvTSDAFSIILDFLYSGKLDLCGE 93
Cdd:cd18238    6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDI-DEEAVELLVDFAYTGKLTLTVD 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 224591419  94 NVIEVMSAASYLQMNDVVNFCKTYIRSSLDI 124
Cdd:cd18238   85 NVQSLLYAASLLQVEEVAKACCEFMKDHLHP 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   8 AKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIhyiqdSG----RHSTASLDIVTSDAFSIILDFL 83
Cdd:cd18326   10 SDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFT-----SGavvdQQNVYEIDFVSAEALTALLDFA 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 224591419  84 YSGKLDLCGENVIEVMSAASYLQMNDVVNFC 114
Cdd:cd18326   85 YTATLTVSTSNVGDILSAARLLEIPAVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   2 EMQSYYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHyiQDSGRHSTASLDIVTSDAFSIILD 81
Cdd:cd18277    6 ESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVG--QADAELNITLPEEVTVKGFEPLIQ 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 224591419  82 FLYSGKLDLCGENVIEVMSAASYLQMNDVVNFCKTYI 118
Cdd:cd18277   84 FAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   5 SYYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIvTSDAFSIILDFLY 84
Cdd:cd18192    3 SHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKI-SAECFDLILQFMY 81

                         90       100
                 ....*....|....*....|...
gi 224591419  85 SGKLDLCGENVIEVMSAASYLQM 107
Cdd:cd18192   82 LGKIMTAPSDFEQLKVAMNYLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591419   1 MEMQSYYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYF--RALLihyiQDSGRhsTASLDIVTSDAFSI 78
Cdd:cd18227    3 VEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFcdQVLL----KNSRR--IVLPDVMNPRVFEN 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 224591419  79 ILDFLYSGKLDLCGENVIEVMSAASYLQMNDVVNFC 114
Cdd:cd18227   77 ILLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.