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RecName: Full=UPAR/Ly6 domain-containing protein qvr; AltName: Full=Protein quiver; AltName: Full=Protein sleepless; Flags: Precursor
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
TFP_LU_ECD_Qvr | cd23595 | extracellular domain (ECD) found in Drosophila melanogaster protein quiver and similar ... |
37-127 | 8.35e-39 | |||
extracellular domain (ECD) found in Drosophila melanogaster protein quiver and similar proteins; Quiver (Qvr, also called protein SLEEPLESS) is a glycosylphosphatidylinositol (GPI)-anchored protein required for homeostatic regulation of sleep under normal conditions and after sleep deprivation in Drosophila. It is a bifunctional regulator of excitability and cholinergic synaptic transmission. It is critical for regulating the levels, localization, and activity of the sleep-modulating potassium channel Shaker. Quiver is a member of the Drosophila Ly6 superfamily. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). : Pssm-ID: 467124 Cd Length: 90 Bit Score: 127.09 E-value: 8.35e-39
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Name | Accession | Description | Interval | E-value | |||
TFP_LU_ECD_Qvr | cd23595 | extracellular domain (ECD) found in Drosophila melanogaster protein quiver and similar ... |
37-127 | 8.35e-39 | |||
extracellular domain (ECD) found in Drosophila melanogaster protein quiver and similar proteins; Quiver (Qvr, also called protein SLEEPLESS) is a glycosylphosphatidylinositol (GPI)-anchored protein required for homeostatic regulation of sleep under normal conditions and after sleep deprivation in Drosophila. It is a bifunctional regulator of excitability and cholinergic synaptic transmission. It is critical for regulating the levels, localization, and activity of the sleep-modulating potassium channel Shaker. Quiver is a member of the Drosophila Ly6 superfamily. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467124 Cd Length: 90 Bit Score: 127.09 E-value: 8.35e-39
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QVR | pfam17064 | Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for ... |
39-127 | 1.90e-15 | |||
Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for homoeostatic regulation of sleep under normal conditions and following sleep deprivation. It is a novel potassium channel subunit that modulates the Shaker potassium channel which regulates the sleep. Pssm-ID: 435716 Cd Length: 85 Bit Score: 67.24 E-value: 1.90e-15
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Name | Accession | Description | Interval | E-value | |||
TFP_LU_ECD_Qvr | cd23595 | extracellular domain (ECD) found in Drosophila melanogaster protein quiver and similar ... |
37-127 | 8.35e-39 | |||
extracellular domain (ECD) found in Drosophila melanogaster protein quiver and similar proteins; Quiver (Qvr, also called protein SLEEPLESS) is a glycosylphosphatidylinositol (GPI)-anchored protein required for homeostatic regulation of sleep under normal conditions and after sleep deprivation in Drosophila. It is a bifunctional regulator of excitability and cholinergic synaptic transmission. It is critical for regulating the levels, localization, and activity of the sleep-modulating potassium channel Shaker. Quiver is a member of the Drosophila Ly6 superfamily. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467124 Cd Length: 90 Bit Score: 127.09 E-value: 8.35e-39
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QVR | pfam17064 | Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for ... |
39-127 | 1.90e-15 | |||
Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for homoeostatic regulation of sleep under normal conditions and following sleep deprivation. It is a novel potassium channel subunit that modulates the Shaker potassium channel which regulates the sleep. Pssm-ID: 435716 Cd Length: 85 Bit Score: 67.24 E-value: 1.90e-15
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TFP_LU_ECD_Rtv | cd23589 | extracellular domain (ECD) found in Drosophila melanogaster protein retroactive and similar ... |
41-129 | 4.37e-06 | |||
extracellular domain (ECD) found in Drosophila melanogaster protein retroactive and similar proteins; Retroactive (Rtv) is a membrane-anchored extracellular protein required for cuticle organization in the larva of Drosophila melanogaster. It is a member of the Drosophila Ly6 superfamily. Retroactive contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467118 Cd Length: 94 Bit Score: 42.81 E-value: 4.37e-06
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TFP_LU_ECD_Crok | cd23592 | extracellular domain (ECD), Ly6/uPAR superfamily, three finger domain (TFD) fold, found in ... |
38-129 | 1.28e-03 | |||
extracellular domain (ECD), Ly6/uPAR superfamily, three finger domain (TFD) fold, found in Drosophila melanogaster protein crooked and similar proteins; Crooked (Crok) is a glycosylphosphatidylinositol (GPI)-anchored protein that plays an essential role in septa formation, the membrane accumulation of SJ components and paracellular barrier functions. It required for septate junction (SJ) formation and function in a tissue-autonomous manner. Crooked is specifically required for correct membrane trafficking of Neurexin IV, a central SJ component. Crooked is a member of the Drosophila Ly6 superfamily. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467121 Cd Length: 104 Bit Score: 36.32 E-value: 1.28e-03
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TFP | cd00117 | three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ... |
39-127 | 3.61e-03 | |||
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances. Pssm-ID: 467060 Cd Length: 81 Bit Score: 34.77 E-value: 3.61e-03
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