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Conserved domains on  [gi|224127398|ref|XP_002320064|]
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brefeldin A-inhibited guanine nucleotide-exchange protein 2 [Populus trichocarpa]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 11477399)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 1-1783 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 3635.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398    1 MASTEADSRLSQVVSPALEKIIKNASWRKHSKLGHECKSVLEILTSPEPQEQPPPTSTSDDSSPSESSLPapLHDGGSHE 80
Cdd:PLN03076    1 MASSEADSRLGKVVSPALEKIIKNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSASASSLPGP--LHDGGSIE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398   81 YSLAESETILSPLINACNTQFLKIVDPAVDCIQKLIAHGYIRGEADPTGGAEAKLLAKLIESVCKCYDLGDDGVELLVLR 160
Cdd:PLN03076   79 YSLAESELILSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHDLGDEGIELLVLK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  161 TLLSAVTSISLRIHGDSLLQIVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPMEKS 240
Cdd:PLN03076  159 TLLSAVTSTSLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPAEKS 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  241 DVDGSMAVFVQGFITKIMQDIDGVLNPGTPSKASMMGAHDGAFETTTSTVEStNPADLLDSTDKDMLDAKYWEISMYKTA 320
Cdd:PLN03076  239 DSDTSMTQFVQGFITKIMQDIDGVLNPATAGKSSGSGAHDGAFETTATVETT-NPADLLDSTDKDMLDAKYWEISMYKSA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  321 LEGRKGELADGEGERDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALTDPQLMRGKIVALELLKILLENAGAVFRT 400
Cdd:PLN03076  318 LEGRKGELADGEVEKDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALADPQLMRGKILALELLKILLENAGAVFRT 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  401 SDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNYQQKIIVLRFL 480
Cdd:PLN03076  398 SDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQKMIVLRFL 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  481 DKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGAPPGTATTLLPPQEVSMKLEAMKCLVGILKSMGDWMNKQL 560
Cdd:PLN03076  478 DKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQL 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  561 RIPDPHSTKKPDAAENSPEPGSLPMANGNGDEPVDGSDSHSETSTEASDVSTIEQRRAYKLELQEGISLFNRKPKKGIEF 640
Cdd:PLN03076  558 RLPDPASLKKLDAVENNLEPGSLPVANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEF 637

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  641 LINANKVGHSAEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQDLEFDEAIRVFLQGFRLPGEAQKIDR 720
Cdd:PLN03076  638 LINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDR 717

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  721 IMEKFAERYCKCNPKVFSSADTAYVLAYSVIMLNTDAHNPMVKSKMSADDFIRNNRGIDDGKDLPEEFLRSLFERISKSE 800
Cdd:PLN03076  718 IMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNE 797

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  801 IKMKEDNLDLQQKQSLNSNRILGLDSILNIVIRKRGEEKHMETSDDLIRHMQEQFKEKARKSESVYYAATDVVILRFMVE 880
Cdd:PLN03076  798 IKMKEDDLVPQQKQSANSNRILGLDSILNIVIRKRGEDSYMETSDDLIKHMQEQFKEKARKSESVYYAATDVVILRFMVE 877

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  881 VCWAPMLAAFSVPLDQSDDEVVIALCLEGIRCAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVTIA 960
Cdd:PLN03076  878 VCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVSIA 957

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  961 DEDGNYLQEAWEHILTCVSRFEHLHLMGEGAPPDATFFAFPQSDSEKSKQTKSTILPVLKKKGPGRMQYAAASVMRGSYD 1040
Cdd:PLN03076  958 DEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATFFAAPQNESDKSKQAKSPILPVLKRKGPGKLQYAAAAVRRGSYD 1037

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1041 SAGIGGNTAGAVTSEQMNNLVSNLNMLEQVGSSEMSRIFTRSQKLNSEAIIDFVKALCKVSMEELRSASDPRVFSLTKIV 1120
Cdd:PLN03076 1038 SAGVGGKASGVVTSEQMNNLVSNLNMLEQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIV 1117

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1121 EIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAV 1200
Cdd:PLN03076 1118 EIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAV 1197

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1201 EIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIRDYFPYITETETTTFTDCVNCLIAF 1280
Cdd:PLN03076 1198 EIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAF 1277

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1281 TNSRFNKDISLNAIAFLRFCATKLAEGDLGFSSRNKDKEAPgkisIPSPRTGKDGKQENGEITDREDHLYFWFPLLAGLS 1360
Cdd:PLN03076 1278 TNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAP----PSSPQSGKDGKQESGEFTDKDDHLYFWFPLLAGLS 1353

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1361 ELSFDPRPEIRKSALQILFETLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPTGGDAPE-QGIDGDTGELDQDAWLY 1439
Cdd:PLN03076 1354 ELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPSGGDEPEgQGVDGDQGELDQDAWLY 1433

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1440 ETCTLALQLVVDLFVKFYNTVNPLLRKVLLLLVSFIRRPHQSLAGIGIAAFVRLMSNAGDLFSEEKWLEVVLSLKEAANA 1519
Cdd:PLN03076 1434 ETCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANA 1513

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1520 TLPDFSYIVSGE---ASVISHEQSDGEKSGDMPDGDSEGLMAHRLYSSISDAKCRAAVQLLLIQAVMEIYSMYRSHLSAK 1596
Cdd:PLN03076 1514 TLPDFSYVVSGEympAENIQDSENAEAASSSTADNDAEAERSRRLYAAISDAKCRAAVQLLLIQAVMEIYNMYRPRLSAK 1593

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1597 SALVLFDALHDVASHAHSINTNIALRSKLLEFGSMTQMQDPPLLRLENESYQICLTFLQNLILDRPPTYDEAQVESCLVN 1676
Cdd:PLN03076 1594 NTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQDPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVE 1673

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1677 LCEEVLQFYIATAHAGQTSETSPSGQSQWLIPLGSGKRRELATRAPLIVATLQAICSLGDSLFEKNLAHFFPLLSSLISC 1756
Cdd:PLN03076 1674 LCEEVLQFYIETSTAGQDSEDSSSQQPRWLIPLGSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFPLLAGLISC 1753

                        1770      1780
                  ....*....|....*....|....*..
gi 224127398 1757 EHGSNEVQVALSDMLSSSVGPVLLRSC 1783
Cdd:PLN03076 1754 EHGSNEVQVALSDMLSSWVGPVLLQSC 1780
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 1-1783 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 3635.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398    1 MASTEADSRLSQVVSPALEKIIKNASWRKHSKLGHECKSVLEILTSPEPQEQPPPTSTSDDSSPSESSLPapLHDGGSHE 80
Cdd:PLN03076    1 MASSEADSRLGKVVSPALEKIIKNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSASASSLPGP--LHDGGSIE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398   81 YSLAESETILSPLINACNTQFLKIVDPAVDCIQKLIAHGYIRGEADPTGGAEAKLLAKLIESVCKCYDLGDDGVELLVLR 160
Cdd:PLN03076   79 YSLAESELILSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHDLGDEGIELLVLK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  161 TLLSAVTSISLRIHGDSLLQIVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPMEKS 240
Cdd:PLN03076  159 TLLSAVTSTSLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPAEKS 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  241 DVDGSMAVFVQGFITKIMQDIDGVLNPGTPSKASMMGAHDGAFETTTSTVEStNPADLLDSTDKDMLDAKYWEISMYKTA 320
Cdd:PLN03076  239 DSDTSMTQFVQGFITKIMQDIDGVLNPATAGKSSGSGAHDGAFETTATVETT-NPADLLDSTDKDMLDAKYWEISMYKSA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  321 LEGRKGELADGEGERDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALTDPQLMRGKIVALELLKILLENAGAVFRT 400
Cdd:PLN03076  318 LEGRKGELADGEVEKDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALADPQLMRGKILALELLKILLENAGAVFRT 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  401 SDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNYQQKIIVLRFL 480
Cdd:PLN03076  398 SDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQKMIVLRFL 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  481 DKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGAPPGTATTLLPPQEVSMKLEAMKCLVGILKSMGDWMNKQL 560
Cdd:PLN03076  478 DKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQL 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  561 RIPDPHSTKKPDAAENSPEPGSLPMANGNGDEPVDGSDSHSETSTEASDVSTIEQRRAYKLELQEGISLFNRKPKKGIEF 640
Cdd:PLN03076  558 RLPDPASLKKLDAVENNLEPGSLPVANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEF 637

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  641 LINANKVGHSAEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQDLEFDEAIRVFLQGFRLPGEAQKIDR 720
Cdd:PLN03076  638 LINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDR 717

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  721 IMEKFAERYCKCNPKVFSSADTAYVLAYSVIMLNTDAHNPMVKSKMSADDFIRNNRGIDDGKDLPEEFLRSLFERISKSE 800
Cdd:PLN03076  718 IMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNE 797

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  801 IKMKEDNLDLQQKQSLNSNRILGLDSILNIVIRKRGEEKHMETSDDLIRHMQEQFKEKARKSESVYYAATDVVILRFMVE 880
Cdd:PLN03076  798 IKMKEDDLVPQQKQSANSNRILGLDSILNIVIRKRGEDSYMETSDDLIKHMQEQFKEKARKSESVYYAATDVVILRFMVE 877

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  881 VCWAPMLAAFSVPLDQSDDEVVIALCLEGIRCAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVTIA 960
Cdd:PLN03076  878 VCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVSIA 957

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  961 DEDGNYLQEAWEHILTCVSRFEHLHLMGEGAPPDATFFAFPQSDSEKSKQTKSTILPVLKKKGPGRMQYAAASVMRGSYD 1040
Cdd:PLN03076  958 DEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATFFAAPQNESDKSKQAKSPILPVLKRKGPGKLQYAAAAVRRGSYD 1037

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1041 SAGIGGNTAGAVTSEQMNNLVSNLNMLEQVGSSEMSRIFTRSQKLNSEAIIDFVKALCKVSMEELRSASDPRVFSLTKIV 1120
Cdd:PLN03076 1038 SAGVGGKASGVVTSEQMNNLVSNLNMLEQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIV 1117

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1121 EIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAV 1200
Cdd:PLN03076 1118 EIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAV 1197

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1201 EIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIRDYFPYITETETTTFTDCVNCLIAF 1280
Cdd:PLN03076 1198 EIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAF 1277

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1281 TNSRFNKDISLNAIAFLRFCATKLAEGDLGFSSRNKDKEAPgkisIPSPRTGKDGKQENGEITDREDHLYFWFPLLAGLS 1360
Cdd:PLN03076 1278 TNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAP----PSSPQSGKDGKQESGEFTDKDDHLYFWFPLLAGLS 1353

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1361 ELSFDPRPEIRKSALQILFETLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPTGGDAPE-QGIDGDTGELDQDAWLY 1439
Cdd:PLN03076 1354 ELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPSGGDEPEgQGVDGDQGELDQDAWLY 1433

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1440 ETCTLALQLVVDLFVKFYNTVNPLLRKVLLLLVSFIRRPHQSLAGIGIAAFVRLMSNAGDLFSEEKWLEVVLSLKEAANA 1519
Cdd:PLN03076 1434 ETCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANA 1513

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1520 TLPDFSYIVSGE---ASVISHEQSDGEKSGDMPDGDSEGLMAHRLYSSISDAKCRAAVQLLLIQAVMEIYSMYRSHLSAK 1596
Cdd:PLN03076 1514 TLPDFSYVVSGEympAENIQDSENAEAASSSTADNDAEAERSRRLYAAISDAKCRAAVQLLLIQAVMEIYNMYRPRLSAK 1593

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1597 SALVLFDALHDVASHAHSINTNIALRSKLLEFGSMTQMQDPPLLRLENESYQICLTFLQNLILDRPPTYDEAQVESCLVN 1676
Cdd:PLN03076 1594 NTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQDPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVE 1673

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1677 LCEEVLQFYIATAHAGQTSETSPSGQSQWLIPLGSGKRRELATRAPLIVATLQAICSLGDSLFEKNLAHFFPLLSSLISC 1756
Cdd:PLN03076 1674 LCEEVLQFYIETSTAGQDSEDSSSQQPRWLIPLGSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFPLLAGLISC 1753

                        1770      1780
                  ....*....|....*....|....*..
gi 224127398 1757 EHGSNEVQVALSDMLSSSVGPVLLRSC 1783
Cdd:PLN03076 1754 EHGSNEVQVALSDMLSSWVGPVLLQSC 1780
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 620-801 2.27e-100

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 319.79  E-value: 2.27e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398   620 KLELQEGISLFNRKPKKGIEFLINANKVGHSAEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQDLEFD 699
Cdd:pfam01369    2 KKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRID 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398   700 EAIRVFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKVFSSADTAYVLAYSVIMLNTDAHNPMVKSKMSADDFIRNNRGID 779
Cdd:pfam01369   82 EALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRGIN 161

                          170       180
                   ....*....|....*....|..
gi 224127398   780 DGKDLPEEFLRSLFERISKSEI 801
Cdd:pfam01369  162 DGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 619-801 9.30e-87

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 281.03  E-value: 9.30e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  619 YKLELQEGISLFNRKPKKGIEFLINANKV-GHSAEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQDLE 697
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  698 FDEAIRVFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKVF-SSADTAYVLAYSVIMLNTDAHNPMVKSKMSADDFIRNNR 776
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFsSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLR 160

                         170       180
                  ....*....|....*....|....*
gi 224127398  777 GIDDGKDLPEEFLRSLFERISKSEI 801
Cdd:cd00171   161 GINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 617-801 1.31e-78

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 257.60  E-value: 1.31e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398    617 RAYKLELQEGISLFNRKPKKGIEFLINANKVGH-SAEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQD 695
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398    696 LEFDEAIRVFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKVFS--SADTAYVLAYSVIMLNTDAHNPMVKSKMSADDFIR 773
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSkaNADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 224127398    774 NNRGIDDGKDLPEEFLRSLFERISKSEI 801
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 1-1783 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 3635.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398    1 MASTEADSRLSQVVSPALEKIIKNASWRKHSKLGHECKSVLEILTSPEPQEQPPPTSTSDDSSPSESSLPapLHDGGSHE 80
Cdd:PLN03076    1 MASSEADSRLGKVVSPALEKIIKNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSASASSLPGP--LHDGGSIE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398   81 YSLAESETILSPLINACNTQFLKIVDPAVDCIQKLIAHGYIRGEADPTGGAEAKLLAKLIESVCKCYDLGDDGVELLVLR 160
Cdd:PLN03076   79 YSLAESELILSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHDLGDEGIELLVLK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  161 TLLSAVTSISLRIHGDSLLQIVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPMEKS 240
Cdd:PLN03076  159 TLLSAVTSTSLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPAEKS 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  241 DVDGSMAVFVQGFITKIMQDIDGVLNPGTPSKASMMGAHDGAFETTTSTVEStNPADLLDSTDKDMLDAKYWEISMYKTA 320
Cdd:PLN03076  239 DSDTSMTQFVQGFITKIMQDIDGVLNPATAGKSSGSGAHDGAFETTATVETT-NPADLLDSTDKDMLDAKYWEISMYKSA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  321 LEGRKGELADGEGERDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALTDPQLMRGKIVALELLKILLENAGAVFRT 400
Cdd:PLN03076  318 LEGRKGELADGEVEKDDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALADPQLMRGKILALELLKILLENAGAVFRT 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  401 SDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNYQQKIIVLRFL 480
Cdd:PLN03076  398 SDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQKMIVLRFL 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  481 DKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGAPPGTATTLLPPQEVSMKLEAMKCLVGILKSMGDWMNKQL 560
Cdd:PLN03076  478 DKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQL 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  561 RIPDPHSTKKPDAAENSPEPGSLPMANGNGDEPVDGSDSHSETSTEASDVSTIEQRRAYKLELQEGISLFNRKPKKGIEF 640
Cdd:PLN03076  558 RLPDPASLKKLDAVENNLEPGSLPVANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEF 637

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  641 LINANKVGHSAEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQDLEFDEAIRVFLQGFRLPGEAQKIDR 720
Cdd:PLN03076  638 LINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDR 717

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  721 IMEKFAERYCKCNPKVFSSADTAYVLAYSVIMLNTDAHNPMVKSKMSADDFIRNNRGIDDGKDLPEEFLRSLFERISKSE 800
Cdd:PLN03076  718 IMEKFAERYCKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNE 797

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  801 IKMKEDNLDLQQKQSLNSNRILGLDSILNIVIRKRGEEKHMETSDDLIRHMQEQFKEKARKSESVYYAATDVVILRFMVE 880
Cdd:PLN03076  798 IKMKEDDLVPQQKQSANSNRILGLDSILNIVIRKRGEDSYMETSDDLIKHMQEQFKEKARKSESVYYAATDVVILRFMVE 877

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  881 VCWAPMLAAFSVPLDQSDDEVVIALCLEGIRCAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVTIA 960
Cdd:PLN03076  878 VCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVSIA 957

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  961 DEDGNYLQEAWEHILTCVSRFEHLHLMGEGAPPDATFFAFPQSDSEKSKQTKSTILPVLKKKGPGRMQYAAASVMRGSYD 1040
Cdd:PLN03076  958 DEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPDATFFAAPQNESDKSKQAKSPILPVLKRKGPGKLQYAAAAVRRGSYD 1037

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1041 SAGIGGNTAGAVTSEQMNNLVSNLNMLEQVGSSEMSRIFTRSQKLNSEAIIDFVKALCKVSMEELRSASDPRVFSLTKIV 1120
Cdd:PLN03076 1038 SAGVGGKASGVVTSEQMNNLVSNLNMLEQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIV 1117

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1121 EIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAV 1200
Cdd:PLN03076 1118 EIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAV 1197

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1201 EIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIRDYFPYITETETTTFTDCVNCLIAF 1280
Cdd:PLN03076 1198 EIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAF 1277

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1281 TNSRFNKDISLNAIAFLRFCATKLAEGDLGFSSRNKDKEAPgkisIPSPRTGKDGKQENGEITDREDHLYFWFPLLAGLS 1360
Cdd:PLN03076 1278 TNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAP----PSSPQSGKDGKQESGEFTDKDDHLYFWFPLLAGLS 1353

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1361 ELSFDPRPEIRKSALQILFETLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPTGGDAPE-QGIDGDTGELDQDAWLY 1439
Cdd:PLN03076 1354 ELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPSGGDEPEgQGVDGDQGELDQDAWLY 1433

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1440 ETCTLALQLVVDLFVKFYNTVNPLLRKVLLLLVSFIRRPHQSLAGIGIAAFVRLMSNAGDLFSEEKWLEVVLSLKEAANA 1519
Cdd:PLN03076 1434 ETCTLALQLVVDLFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANA 1513

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1520 TLPDFSYIVSGE---ASVISHEQSDGEKSGDMPDGDSEGLMAHRLYSSISDAKCRAAVQLLLIQAVMEIYSMYRSHLSAK 1596
Cdd:PLN03076 1514 TLPDFSYVVSGEympAENIQDSENAEAASSSTADNDAEAERSRRLYAAISDAKCRAAVQLLLIQAVMEIYNMYRPRLSAK 1593

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1597 SALVLFDALHDVASHAHSINTNIALRSKLLEFGSMTQMQDPPLLRLENESYQICLTFLQNLILDRPPTYDEAQVESCLVN 1676
Cdd:PLN03076 1594 NTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQDPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVE 1673

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398 1677 LCEEVLQFYIATAHAGQTSETSPSGQSQWLIPLGSGKRRELATRAPLIVATLQAICSLGDSLFEKNLAHFFPLLSSLISC 1756
Cdd:PLN03076 1674 LCEEVLQFYIETSTAGQDSEDSSSQQPRWLIPLGSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFPLLAGLISC 1753

                        1770      1780
                  ....*....|....*....|....*..
gi 224127398 1757 EHGSNEVQVALSDMLSSSVGPVLLRSC 1783
Cdd:PLN03076 1754 EHGSNEVQVALSDMLSSWVGPVLLQSC 1780
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 620-801 2.27e-100

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 319.79  E-value: 2.27e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398   620 KLELQEGISLFNRKPKKGIEFLINANKVGHSAEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQDLEFD 699
Cdd:pfam01369    2 KKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRID 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398   700 EAIRVFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKVFSSADTAYVLAYSVIMLNTDAHNPMVKSKMSADDFIRNNRGID 779
Cdd:pfam01369   82 EALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRGIN 161

                          170       180
                   ....*....|....*....|..
gi 224127398   780 DGKDLPEEFLRSLFERISKSEI 801
Cdd:pfam01369  162 DGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 619-801 9.30e-87

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 281.03  E-value: 9.30e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  619 YKLELQEGISLFNRKPKKGIEFLINANKV-GHSAEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQDLE 697
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  698 FDEAIRVFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKVF-SSADTAYVLAYSVIMLNTDAHNPMVKSKMSADDFIRNNR 776
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFsSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLR 160

                         170       180
                  ....*....|....*....|....*
gi 224127398  777 GIDDGKDLPEEFLRSLFERISKSEI 801
Cdd:cd00171   161 GINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 617-801 1.31e-78

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 257.60  E-value: 1.31e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398    617 RAYKLELQEGISLFNRKPKKGIEFLINANKVGH-SAEEIAAFLKNASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQD 695
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398    696 LEFDEAIRVFLQGFRLPGEAQKIDRIMEKFAERYCKCNPKVFS--SADTAYVLAYSVIMLNTDAHNPMVKSKMSADDFIR 773
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSkaNADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 224127398    774 NNRGIDDGKDLPEEFLRSLFERISKSEI 801
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 347-502 1.04e-51

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 179.23  E-value: 1.04e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398   347 LRRDAFLVFRALCKLSMKTPPKEALTDPQLMRGKIVALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMI 426
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSNGKPLSKSDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSSFP 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 224127398   427 IFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAqpNYQQKIIVLRFLDKLCVDSQILVDIFINYDCDVN 502
Cdd:pfam12783   81 VFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLESDS--SLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1573-1772 5.56e-43

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 155.09  E-value: 5.56e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  1573 AVQLLLIQAVMEIYSMYRSHLSAKSALVLFDALHDVASHAHSINTNIALRSKLLEFGSMTQMqdPPLLRLENESYQICLT 1652
Cdd:pfam20252    1 VVQLLLIQTVNEILDEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLELRTALWRAGFMKQL--PNLLKQETSSLSTYLR 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  1653 FLQNLILD-RPPTYDEAQVESCLVNLCEEVLQFYIATAHagqtsetspsgqsqwliplgSGKRRELATRAPLIVATLQAI 1731
Cdd:pfam20252   79 ILFRLYADdEPRTSQREEVEERLIPLCEDILEYYLSLDE--------------------EEKQRELAAWTPVVVLILQGL 138

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 224127398  1732 CSLGDSLFEKNLAHFFPLLSSLISCEhGSNEVQVALSDMLS 1772
Cdd:pfam20252  139 LALPDDDFRRHLPEFYPLLCDLILCE-LSPEVRLALREFFS 178
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 6-216 1.19e-41

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 151.25  E-value: 1.19e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398     6 ADSRLSQVVSPALeKIIKNASWRKHSKLGHECKSVLEILTSpepqeqppptstsddsspsesslpapLHDGGSHEYSLA- 84
Cdd:pfam16213    1 QGSKLLEALQSDL-RTLSSEAKRKYPPVKEASEKGILRLRT--------------------------VHSSSPLMQNLLs 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398    85 ESETILSPLINACNTQFLKIVDPAVDCIQKLIAHGYIRGEADPtggaeakllaKLIESVCKCYDLGDDgVELLVLRTLLS 164
Cdd:pfam16213   54 ASEDILKPFVLACETKNPKLVQIALGCLQKLISHDAISQSAAP----------YILDTLWMLMELGSE-IELKVLQTVLL 122

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 224127398   165 AVTSISlRIHGDSLLQIVRTCYDIYLgSKNVVNQTTAKASLIQMLVIVFRRM 216
Cdd:pfam16213  123 LITTNS-VIHGDTLAKALVLCFRLHF-SKDPTVQNTASATLRQLVSVVFERV 172
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1170-1253 3.75e-36

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 131.84  E-value: 3.75e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  1170 KFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFE 1249
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ....
gi 224127398  1250 IIEK 1253
Cdd:pfam09324   81 ILEL 84
Mon2_C pfam16206
C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and ...
 1351-1453 1.33e-11

C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and is a scaffold protein involved in multiple aspects of endo membrane trafficking. This C-terminal region is essential for Mon2 activity.


Pssm-ID: 465066  Cd Length: 827  Bit Score: 69.76  E-value: 1.33e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224127398  1351 FWFPLLAGLSELSFDPRPEIRKSALQILFETLRNHGHLFSLPLWERVFESVLFPIFDYVRHaidpTGGDAPEQGIDGDTG 1430
Cdd:pfam16206   92 LWLCLYAKLGELCVDLRPAVRKSAGQTLFSTIGAHGSLLNHPTWHALIWKVLFNLLDNVRA----LSSSADKEKIDAGGG 167

                           90       100       110
                   ....*....|....*....|....*....|.
gi 224127398  1431 EL--------DQDAWLyETCTLALQLVVDLF 1453
Cdd:pfam16206  168 NIlihhsrdtAEKQWA-ETQVLTLAGVARIF 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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