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Conserved domains on  [gi|223951272|gb|ACN29565|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Gobiobotia brevibarba]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475913)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-348 0e+00

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 568.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   1 MNPYVLMVLLSSLGLGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWI 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  81 SGEWDMNNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAvDPLLLTSLGLM 160
Cdd:MTH00135  81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPT-NPTLLITLGLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 161 STRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIFMTSAAFLTLKTSSATKINTLAMVWSNNPTL 240
Cdd:MTH00135 160 STLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 241 MTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAMTLTISPNTTNSTTPWRVQTT 320
Cdd:MTH00135 240 TALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPST 319

                        330       340
                 ....*....|....*....|....*...
gi 223951272 321 QLSLPLTISTTAALGLLPLTPAILMLVT 348
Cdd:MTH00135 320 QLTLPLAISTTATLMLLPLTPAILALLT 347
 
Name Accession Description Interval E-value
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-348 0e+00

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 568.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   1 MNPYVLMVLLSSLGLGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWI 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  81 SGEWDMNNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAvDPLLLTSLGLM 160
Cdd:MTH00135  81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPT-NPTLLITLGLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 161 STRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIFMTSAAFLTLKTSSATKINTLAMVWSNNPTL 240
Cdd:MTH00135 160 STLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 241 MTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAMTLTISPNTTNSTTPWRVQTT 320
Cdd:MTH00135 240 TALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPST 319

                        330       340
                 ....*....|....*....|....*...
gi 223951272 321 QLSLPLTISTTAALGLLPLTPAILMLVT 348
Cdd:MTH00135 320 QLTLPLAISTTATLMLLPLTPAILALLT 347
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 4-300 2.34e-26

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 109.05  E-value: 2.34e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   4 YVLMVLLSSLGLgtTLTFASSHWLLAWMGLEINTLAIVPLMA-QHHHPRAVEATTKYFLTQATAAAMILF--------AS 74
Cdd:COG1007  104 FYALLLFATLGM--MLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLYgisllygaTG 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  75 TTN----AWISGEWDMNNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVD 150
Cdd:COG1007  182 SLNlagiAAALAAGGANSPLLLLGLVLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLVEAF 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 151 P-------LLLTSLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQL----TLLALGTYIFMTSAAFLTL 219
Cdd:COG1007  262 PglaadwqLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLgvsaALFYLLAYLFMNLGAFAVI 341

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 220 -----KTSSATKINTLAMVWSNNPTLMTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYL 294
Cdd:COG1007  342 lllsrKGGEAEEIEDLAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYL 421


                 ....*.
gi 223951272 295 RLCYAM 300
Cdd:COG1007  422 RVVKAM 427
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 4-300 1.90e-20

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 91.93  E-value: 1.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272    4 YVLMVLLSSLGLGttLTFASSHWLLAWMGLEINTLAIVPLMA-QHHHPRAVEATTKYFLTQATAAAMILFASTTNAWISG 82
Cdd:TIGR01770 104 FYILLLFALLGIF--LLVSSNDLLSIYLGLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTG 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   83 EWDMNNLSSPVATTM------------IITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQ------ 144
Cdd:TIGR01770 182 SLNFEDLLLFLSNGMlnisllllgivlILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRlflyil 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  145 -TAQAVDPLLLTSLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALG----TYIFMTSAAFLTL 219
Cdd:TIGR01770 262 fGFSEAWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLfyifIYALMSLGAFGVL 341

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  220 KTSSATK------INTLAMVWSNNPTLMTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFY 293
Cdd:TIGR01770 342 SLLRSYKdewieyISDFAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYY 421


                  ....*..
gi 223951272  294 LRLCYAM 300
Cdd:TIGR01770 422 LRVVKVM 428
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-268 3.37e-20

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 89.29  E-value: 3.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   23 SSHWLLAWMGLEINTLAIVPLMA-QHHHPRAVEATTKYFLTQATAAAMILFASTTNAWISGEWDMNNLSSPVATT----- 96
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTGGlnssg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   97 ------MIITALALKIGLAPMHFWMPEVLQGMDLLTGLIL-STWQKLAPLALI-----IQTAQAVDPLLLTSLGLMSTRA 164
Cdd:pfam00361  81 llllflLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLIrrsllYLPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  165 GGGGGLNQTQLRKILAYSSIAHMGWMVVIL----QYPPQLTLLALGTYIFMTSAAFL-----TLKTSSATKINTLAMVWS 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALgagtIYGIQAAIFHLLTHGLFSAGLFLcagsvIYRRVHTRNIRDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 223951272  236 NNPTLMTTTAVVLLSLGGLPPLTGFMPKWLILQ 268
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILA 273
 
Name Accession Description Interval E-value
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-348 0e+00

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 568.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   1 MNPYVLMVLLSSLGLGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWI 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  81 SGEWDMNNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAvDPLLLTSLGLM 160
Cdd:MTH00135  81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPT-NPTLLITLGLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 161 STRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIFMTSAAFLTLKTSSATKINTLAMVWSNNPTL 240
Cdd:MTH00135 160 STLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 241 MTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAMTLTISPNTTNSTTPWRVQTT 320
Cdd:MTH00135 240 TALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPST 319

                        330       340
                 ....*....|....*....|....*...
gi 223951272 321 QLSLPLTISTTAALGLLPLTPAILMLVT 348
Cdd:MTH00135 320 QLTLPLAISTTATLMLLPLTPAILALLT 347
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-346 4.61e-149

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 423.56  E-value: 4.61e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   1 MNPYVLMVLLSSLGLGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWI 80
Cdd:MTH00070   1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  81 SGEWDMNNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVDPLLLTSLGLM 160
Cdd:MTH00070  81 TGEWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 161 STRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIFMTSAAFLTLKTSSATKINTLAMVWSNNPTL 240
Cdd:MTH00070 161 STLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 241 MTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAMTLTISPNTTNSTTPWRvQTT 320
Cdd:MTH00070 241 TSMMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWR-FKN 319

                        330       340
                 ....*....|....*....|....*.
gi 223951272 321 QLSLPLTISTTAALGLLPLTPAILML 346
Cdd:MTH00070 320 KTNNLLSLTIILSLMLLPITPTILNL 345
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-347 2.48e-128

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 371.08  E-value: 2.48e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   1 MNPYVLMVLLSSLGLGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWI 80
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  81 SGEWDMNNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVDPLLLTSLGLM 160
Cdd:MTH00112  81 TGQWDITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 161 STRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIFMTSAAFLTLKTSSATKINTLAMVWSNNPTL 240
Cdd:MTH00112 161 STLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 241 MTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAMTLTISPNTTNSTTPWRVQTT 320
Cdd:MTH00112 241 NTTLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTKPK 320

                        330       340
                 ....*....|....*....|....*..
gi 223951272 321 QlSLPLTISTTAALGLLPLTPAILMLV 347
Cdd:MTH00112 321 K-NTLTATLTTLSTLLLPLSPMILTII 346
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-346 6.41e-122

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 354.92  E-value: 6.41e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   1 MNPYVLMVLLSSLGLGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWI 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  81 SGEWDMNNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVDPLLLTSLGLM 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 161 STRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIFMTSAAFLTLKTSSATKINTLAMVWSNNPTL 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 241 MTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAMTLTISPNTTNSTTPWRVQTT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330       340
                 ....*....|....*....|....*.
gi 223951272 321 QLSLPLTISTTAALGLLPLTPAILML 346
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSIL 346
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-346 1.24e-112

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 331.16  E-value: 1.24e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   1 MNPYVLMVLLSSLGLGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWI 80
Cdd:MTH00200   1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  81 SGEWDMNNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVDPLLLTSLGLM 160
Cdd:MTH00200  81 SGQWGISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 161 STRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIFMTSAAFLTLKTSSATKINTLAMVWSNNPTL 240
Cdd:MTH00200 161 SVLVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPIL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 241 MTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAMTLTISPNTTNSTTPWRVQTT 320
Cdd:MTH00200 241 SMLLGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKSN 320

                        330       340
                 ....*....|....*....|....*.
gi 223951272 321 qLSLPLTISTTAALGLLPLTPAILML 346
Cdd:MTH00200 321 -SNLLVGLLLLLSILGLPLTPQLLFL 345
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-341 1.48e-87

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 267.18  E-value: 1.48e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   1 MNPYVLMVLLSSLGLGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWI 80
Cdd:MTH00041   1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  81 SGEWDMNNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVDPLLLTSLGLM 160
Cdd:MTH00041  81 SGSWSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 161 STRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIFMTSAAFLTLKTSSATKINTLAMVWSNNPTL 240
Cdd:MTH00041 161 SVLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPIS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 241 MTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAMTLTISPNTTNSTTPWRVQTT 320
Cdd:MTH00041 241 AFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSWRNSGN 320

                        330       340
                 ....*....|....*....|.
gi 223951272 321 QLSLPLTISTTAALGLLPLTP 341
Cdd:MTH00041 321 ITVYGVILSILSSISILGLLL 341
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-312 2.05e-54

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 181.56  E-value: 2.05e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   1 MNPYVLMvLLSSLGLGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWi 80
Cdd:MTH00160   3 MNSSKLL-FLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  81 sgewdMNNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQavdPLLLTSLGLM 160
Cdd:MTH00160  81 -----NLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLIN---NNFIIIIIIL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 161 STRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIFMTSAAFLTLKTSSATKINTLAMVWSNNPTL 240
Cdd:MTH00160 153 SAIIGAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKI 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223951272 241 MTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAMTLTISPNTTNST 312
Cdd:MTH00160 233 KFLLFLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNL 304
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 6-338 8.35e-47

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 161.49  E-value: 8.35e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   6 LMVLLSSLGLGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNawisgeWD 85
Cdd:MTH00011   8 MFLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMM------WS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  86 MNNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVDPLLLTSLGLMSTRAG 165
Cdd:MTH00011  82 FPSLLKNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMAAMSALAG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 166 GGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIFMTSAAFLTLKTSSATKINTLAMVWSNNPTLMTTTA 245
Cdd:MTH00011 162 GLGGMNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLF 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 246 VVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAMTlTISPNTTNSTTPWRVQTTQLSLP 325
Cdd:MTH00011 242 IMLLSLGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFNFM-YLSPTFSSLKSAPYEPKTKILIS 320

                        330
                 ....*....|...
gi 223951272 326 LtisTTAALGLLP 338
Cdd:MTH00011 321 M---CTLSLGLIP 330
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 7-302 1.77e-45

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 158.13  E-value: 1.77e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   7 MVLLSSLGLGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWISGEWDM 86
Cdd:MTH00144   7 LLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWFS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  87 nnlsspvaTTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVDPL-LLTSLGLMSTRAG 165
Cdd:MTH00144  87 --------MSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLAyLLCVISVLSALVG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 166 GGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIFMTSAAFLTLKTSSatkINTLAMVWSNNPTLMTTTA 245
Cdd:MTH00144 159 SIGGLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGD---SGSMKDLGSLKPSYKTGLS 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 223951272 246 VVLLSLGGLPP--LTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAMTL 302
Cdd:MTH00144 236 IISLLLSLGGLppFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFL 294
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 7-298 6.41e-43

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 150.98  E-value: 6.41e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   7 MVLLSSLGLGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAwisgewdM 86
Cdd:MTH00197   1 FLFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSF-------S 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  87 NNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLalIIQTAQAVDPLLLTSLGLMSTRAGG 166
Cdd:MTH00197  74 NLYLSLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPL--LILAFNSSSFMGLLICSVLSSLIGG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 167 GGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIFMTSAAFLTLKTSSATKINTLAMVWSNNPTLMTTTAV 246
Cdd:MTH00197 152 IGGMNQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGL 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 223951272 247 VLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCY 298
Cdd:MTH00197 232 SFLSLGGLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAY 283
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 4-300 2.34e-26

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 109.05  E-value: 2.34e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   4 YVLMVLLSSLGLgtTLTFASSHWLLAWMGLEINTLAIVPLMA-QHHHPRAVEATTKYFLTQATAAAMILF--------AS 74
Cdd:COG1007  104 FYALLLFATLGM--MLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLYgisllygaTG 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  75 TTN----AWISGEWDMNNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVD 150
Cdd:COG1007  182 SLNlagiAAALAAGGANSPLLLLGLVLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLVEAF 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 151 P-------LLLTSLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQL----TLLALGTYIFMTSAAFLTL 219
Cdd:COG1007  262 PglaadwqLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLgvsaALFYLLAYLFMNLGAFAVI 341

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 220 -----KTSSATKINTLAMVWSNNPTLMTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYL 294
Cdd:COG1007  342 lllsrKGGEAEEIEDLAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYL 421


                 ....*.
gi 223951272 295 RLCYAM 300
Cdd:COG1007  422 RVVKAM 427
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 15-296 1.23e-25

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 105.50  E-value: 1.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  15 LGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHP-RAVEATTKYFLTQATAAAMILFASTTNAWISGEWDMN------ 87
Cdd:MTH00196   4 LGILCLISSSNWLSVYLAIELQTLSLFILIAQNRGSgYSAEAGLKYFVLGALSSGLFLFGCALLCGTTGGLHLSyinlvl 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  88 -------NLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVDPLLLtsLGLM 160
Cdd:MTH00196  84 nsgqsfsSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLI--GGLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 161 STRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPP----QLTLLALGTYIFMTSAAFLTLKTSSATK--INTLAMVW 234
Cdd:MTH00196 162 SLFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIGSfesiQASLVYLFIYIIMSICVFSIILALNVYKnlIIEFSGLS 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223951272 235 SNNPTLMTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRL 296
Cdd:MTH00196 242 RRLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRI 303
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 5-296 3.86e-21

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 93.93  E-value: 3.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   5 VLMVLLSSLglgttLTFASSHWLLAWMGLEINTLAIVPLMA-QHHHPRAVEATTKYFLTQATAAAMILFASTTNAWISGE 83
Cdd:MTH00199 103 ILIVALGSL-----LLVSSINWLSIYLAIELQTLTLFILVAlKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTGE 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  84 WDM----NNLSSPVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVDPLLLTslGL 159
Cdd:MTH00199 178 TSIqginSILTGDVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLIC--AV 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 160 MSTRAGGGGGLNQTQLRKILAYSSIAHMG---WMVVILQYPP-QLTLLALGTYIFMTSAAFLTLKTSSATK--INTLAMV 233
Cdd:MTH00199 256 LSIIYGAIGALNQTKIKRLLAYSGIGHMGfilFGVAIGSFESiQASLIYMIIYVIMSICSFSIILSLKLTKglIVEVSGL 335

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223951272 234 WSNNPTLMTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRL 296
Cdd:MTH00199 336 SRKNPVIALTLALTFLSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYYVRV 398
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 4-300 1.90e-20

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 91.93  E-value: 1.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272    4 YVLMVLLSSLGLGttLTFASSHWLLAWMGLEINTLAIVPLMA-QHHHPRAVEATTKYFLTQATAAAMILFASTTNAWISG 82
Cdd:TIGR01770 104 FYILLLFALLGIF--LLVSSNDLLSIYLGLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTG 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   83 EWDMNNLSSPVATTM------------IITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQ------ 144
Cdd:TIGR01770 182 SLNFEDLLLFLSNGMlnisllllgivlILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRlflyil 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  145 -TAQAVDPLLLTSLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALG----TYIFMTSAAFLTL 219
Cdd:TIGR01770 262 fGFSEAWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLfyifIYALMSLGAFGVL 341

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  220 KTSSATK------INTLAMVWSNNPTLMTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFY 293
Cdd:TIGR01770 342 SLLRSYKdewieyISDFAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYY 421


                  ....*..
gi 223951272  294 LRLCYAM 300
Cdd:TIGR01770 422 LRVVKVM 428
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
4-338 2.23e-20

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 91.81  E-value: 2.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   4 YVLMVLLSSLGLgttLTFASS-HWLLAWMGLEINTLAIVPLMAQH-HHPRAVEATTKYFLTQATAAAMILF--------- 72
Cdd:PRK05777 105 FYLLVLFALLGM---MVMVSAnDLLTLFLGLELLSLPLYALAALRrDRRRSLEAAIKYFVLGALASGFLLYgmsllygat 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  73 ASTTNAWISGEWDMNNLSSPV---ATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAV 149
Cdd:PRK05777 182 GSLSFAGIAKALADGSGNSLLllfGLVFLLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRLLVVA 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 150 DP-------LLLTSLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQL----TLLALGTYIFMTSAAF-- 216
Cdd:PRK05777 262 FGglsedwqQVLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEgysaVLFYLLAYLFMTLGAFgv 341

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 217 ---LTLKTSSATKINTLAMVWSNNPTLMTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFY 293
Cdd:PRK05777 342 islLRRKGGEAESISDFAGLSKRSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYY 421

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 223951272 294 LRLCYAMTLtiSPNTTNSTTPWRVQTTQLSLPLTISTTAALGLLP 338
Cdd:PRK05777 422 LRVIKLMYF--DEPPRDAPVNWPLSAGGAVLSVSALLVLVLGIFP 464
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-268 3.37e-20

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 89.29  E-value: 3.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   23 SSHWLLAWMGLEINTLAIVPLMA-QHHHPRAVEATTKYFLTQATAAAMILFASTTNAWISGEWDMNNLSSPVATT----- 96
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTGGlnssg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   97 ------MIITALALKIGLAPMHFWMPEVLQGMDLLTGLIL-STWQKLAPLALI-----IQTAQAVDPLLLTSLGLMSTRA 164
Cdd:pfam00361  81 llllflLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLIrrsllYLPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  165 GGGGGLNQTQLRKILAYSSIAHMGWMVVIL----QYPPQLTLLALGTYIFMTSAAFL-----TLKTSSATKINTLAMVWS 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALgagtIYGIQAAIFHLLTHGLFSAGLFLcagsvIYRRVHTRNIRDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 223951272  236 NNPTLMTTTAVVLLSLGGLPPLTGFMPKWLILQ 268
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILA 273
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 15-300 8.29e-15

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 74.80  E-value: 8.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  15 LGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWISGEWDMNNLSSPVA 94
Cdd:COG0651  118 AGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATGTLNMADLAARLA 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  95 T----------TMIITALALKIGLAPMHFWMPE-----------VLQGMDLLTGL--ILSTWQklapLALIIQTAQAVDP 151
Cdd:COG0651  198 EldpglllaafALLLVGFGIKAALFPLHFWLPDaypaapspvsaLLSGLLTKVGVyaILRVLT----LLFGADPALFLGT 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 152 LLLTsLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYI----FMTSAAFLT----LKTSS 223
Cdd:COG0651  274 LLLV-LGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLlnhaLAKALLFLAagaiERATG 352

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223951272 224 ATKINTLAMVWSNNPTLMTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAM 300
Cdd:COG0651  353 TRDLDKLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRIFGRA 429
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 13-230 5.00e-13

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 69.89  E-value: 5.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  13 LGLGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAV---------EATTKYFLTQATAAAMILFASTTNAWISGE 83
Cdd:MTH00198 197 VGLGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGCALYFGFTGN 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  84 WDM--NNLSSPVATT------------MIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLapLALIIQTAQAV 149
Cdd:MTH00198 277 EGMlgTILSATLETTnielrqgslgylFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKF--TVYILLTSLVI 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 150 DPLLLTSLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIFMtsaaFLTLKTSSATKINT 229
Cdd:MTH00198 355 TSKLLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFILIGVSAGTYESLQASWTYAVT----YLVSALASFTVICT 430


                 .
gi 223951272 230 L 230
Cdd:MTH00198 431 L 431
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 291-341 1.18e-11

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 59.19  E-value: 1.18e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 223951272  291 YFYLRLCYAMTLTISPNTTNSTTPWRVQTTQLSLPLTISTTAALGLLPLTP 341
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKNTLLLPTLTTLSILLLPLTP 51
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 33-347 8.85e-09

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 56.81  E-value: 8.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  33 LEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWISGEWDMNNLSSP--------VATTMIITALAL 104
Cdd:PRK08375 135 LEIMSLSSYALVAMGGDRRALAAARKYLIVGLIGSTFLLIGVGLLYGVTGTLNMADLAGAlaenptvvTAFGFVLLALAL 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 105 KIGLAPMHFWMPEVLQGM-DLLTGLILSTWQKLAPLALIIQTAQAVDP---------LLLTSLGLMSTRAGGGGGLNQTQ 174
Cdd:PRK08375 215 KAAVFPLHTWLPRAYPAApPVVTALLSGLVTKVAVYALIRIYFTVFGGdfrfalglgWLLAVLALLSMLVGSLAALGQDD 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 175 LRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYIF----MTSAAFLTL----KTSSATKINTLAMVWSNNPTLMTTTAV 246
Cdd:PRK08375 295 VKRVLAYSTVSQMGYILLGLALLTPLALAAGLLHLLhhalMKGALFLAAgaieVTYGTRRLSELSGLGRRMPLTAAAFAV 374

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 247 VLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAMTLTISPNttNSTTPWRVQTTQLSLPL 326
Cdd:PRK08375 375 ASLSLIGVPPTSGFVSKWYLVVGAVEAGQWLVLAVLLASSLLALLYFLRIWYRAFFGPPPP--GSEAPKQEAPLGMLAPS 452

                        330       340
                 ....*....|....*....|.
gi 223951272 327 TISTTAALGLLPLTPAILMLV 347
Cdd:PRK08375 453 LALALLSLLLGIYAGPLLQLA 473
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 44-300 1.20e-07

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 53.05  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  44 MAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWISGEWDMNNLS----------------SPVATTMIITALAL--- 104
Cdd:PRK12667 154 AYYRDRGDAVEAAIKYALIGAVGTTLYFLALAFLYATFGTLNMADLSakirglsfpltgglagNPPLALGVALALALwaf 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 105 --KIGLAPMHFWMPEV-----------LQGMDLLTG---------LILSTWQKLAPLALIIQtaqavdpLLLTSLGLMST 162
Cdd:PRK12667 234 tiKAAIFPNHFWLPDAhpaapspvsamLSGLVVNVGayaiirflyTIFGISPSLIDFRAALS-------PILIILGAVSA 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 163 RAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLALGTYI----------FMTSAAFltLKTSSATKINTLAM 232
Cdd:PRK12667 307 IIGALMMVVQKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIinhaiaksllFLASGVF--IHAAGTRDIDELAG 384

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223951272 233 VWSNNPTLMTTTAVVLLSLGGLPPLTGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAM 300
Cdd:PRK12667 385 LGRKMPIASFAFLIGALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLLIASAISLVGYFRAWYSL 452
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
50-300 6.46e-07

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 50.82  E-value: 6.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  50 PRAVEATTKYFLTQATAAAMILFASTTNAWISGE-----------WDMNNLSSPVATTMIITALALKIGLAPMHFWMPEV 118
Cdd:PRK02504 157 PRSNEAALKYLLIGAASSAIFLYGSSLLYGLSGGstqlsaialalITSPSLGLALALVFVIAGIAFKISAVPFHQWTPDV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 119 LQGMDLLTGLILSTWQKLAPLALIIQTAQAVDP-------LLLTSLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMV 191
Cdd:PRK02504 237 YEGSPTPVVAFLSVGSKAAGFALAIRLLVTAFPsfdeqwkLLFTALAILSMVLGNVVALAQTSMKRMLAYSSIGQAGFVM 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 192 VILQYPPQ----LTLLALGTYIFMTSAAFL-----TLKTSSaTKINTLAMVWSNNPTLMTTTAVVLLSLGGLPPLTGFMP 262
Cdd:PRK02504 317 IGLVAGTEagyaSMVFYLLAYLFMNLGAFAcvilfSLRTGT-DQISDYAGLYQKDPLLTLGLSLCLLSLGGIPPLAGFFG 395

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 223951272 263 KwLILQELAKQDLPITATIMAL-AALLSLYFYLRLCYAM 300
Cdd:PRK02504 396 K-IYLFWAGWQAGLYLLVLVGLvTSVISIYYYIRVIKMM 433
ndhB CHL00049
NADH dehydrogenase subunit 2
 51-334 1.05e-06

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 50.00  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  51 RAVEATTKYFLTQATAAAMILFASTTNAWISG-------------EWDM-NNLSSPVATTMIITALALKIGLAPMHFWMP 116
Cdd:CHL00049 159 RSNEATMKYLLMGGASSSILVYGFSWLYGLSGgeielqeivngliNTQMyNSPGISIALIFITVGIGFKLSLAPFHQWTP 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 117 EVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVDP-------LLLTSLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGW 189
Cdd:CHL00049 239 DVYEGSPTPVVAFLSVTSKVAASALATRIFDIPFYfssnewhLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGY 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 190 MVVIL-------QYPPQLTLLALgtYIFMTSAAF-----LTLKTSSaTKINTLAMVWSNNPTLMTTTAVVLLSLGGLPPL 257
Cdd:CHL00049 319 VIIGIivgdsndGYASMITYMLF--YIFMNLGTFacivlFGLRTGT-DNIRDYAGLYTKDPFLALSLALCLLSLGGIPPL 395

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 258 TGFMPKWLILQELAKQDLPITATIMALAALLSLYFYLRLCYAM----TLTISPNTTNSTTPWRVQTTQLSLPLTISTTAA 333
Cdd:CHL00049 396 AGFFGKLYLFWCGWQAGLYFLVSIGLLTSVISIYYYLKIIKLLmtgrNQEITPYVRNYRRSPLRSNNSIELSMIVCVIAS 475


                 .
gi 223951272 334 L 334
Cdd:CHL00049 476 T 476
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 33-300 8.20e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 47.40  E-value: 8.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  33 LEINTLAIVPLMAQHHH-PRAVEATTKYFLTQATAAAMILFA---------STTNAWISGEWDMN-NLSSPVATTMIITA 101
Cdd:PRK08376 150 LEIMSIASYALVAFRNDtWEAIEAGIKYMFVGSLASSMVLLGiallygqygTLNMAYLAVKMSENpTVVAKIALALFIAG 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 102 LALKIGLAPMHFWMP----EVLQGMDLLtgLILSTWQKLAPLALIIQT--AQAVDPL----LLTSLGLMSTRAGGGGGLN 171
Cdd:PRK08376 230 LAMKSGAVPVHMWLPdaypAAPSSISAM--LLVIKQAGLYALARVLFSiyGPAINLAtvgwVIIILGCLTMFVGVAMAVV 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 172 QTQLRKILAYSSIAHMGWMVVILQyppqLTLLALGT--------------------YIFMTSAAFLT-------LKTSSA 224
Cdd:PRK08376 308 QKDVKRLLAYHSVSQIGYMLLGLG----VGLAALGDpamasygeialaggiyhivnHALYKALLFLTagaviyeTGTRNL 383

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223951272 225 TKINTLA--MVWSNNPTLMTTTAVVLLSLGglpplTGFMPKWLILQELAKQDlPITATIMALAALLSLYFYLRLCYAM 300
Cdd:PRK08376 384 NELGGLArtMPKTTIAFLIGAAAIVGLPPF-----NGFASKWLIYESSALFN-PILGVIAMIGSVLTLASFVKVFHTA 455
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
4-204 1.34e-05

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 46.62  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   4 YVLMVLLSSlglGTTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWISG- 82
Cdd:PRK06473 110 YSLLLLLNA---GVSGAFLAQDLLLFFLFYELELIPLYLLIAIWGGQRRGYAATKFLLYTAISGILILVSFLGLVWLSGa 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  83 -EWDMNNLSS---PVATTM-----IITALALKIGLAPMHFWMPE-----------VLQGMDLLTG----------LILST 132
Cdd:PRK06473 187 sSFDYEPLRShtlPLSTQLlllapILVGFGIKIPLVPFHTWLPDahveastpvsvLLAGVLLKLGtygllrfgvgLFPEA 266

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223951272 133 WQKLAPLaliiqtaqavdpllLTSLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMVVILQYPPQLTLLA 204
Cdd:PRK06473 267 WVYLAPW--------------LATWAVVSVLYGASCAIAQKDMKKMVAYSSIGHMGYILLAAAAATPLSILA 324
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
55-203 8.87e-05

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 44.32  E-value: 8.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  55 ATTKYFLTQATAAAMILFASTTNAWISG--EWDMNNLSSP--------VATTMIITALALKIGLAPMHFWMP----EVLQ 120
Cdd:PRK07363 158 ASIKFLIYTAVSGLLVLAAFLGIVWLSGstSFDYDAISTQnlslntqlILLTGLLLGFGIKIPLVPLHTWLPdaytEASP 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 121 GMDLLTGLILStwqKLAP-------LALIIQTAQAVDPLLLTsLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMVVI 193
Cdd:PRK07363 238 AVAILLGGVLA---KLGTygllrfgLQLFPQTWSLVAPGLAI-IGTISVIYGALSAIAQKDIKRMVAYSSIGHMGYILVA 313

                        170
                 ....*....|
gi 223951272 194 LQYPPQLTLL 203
Cdd:PRK07363 314 AAAGTQLSLL 323
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 49-192 5.55e-04

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 41.61  E-value: 5.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  49 HPRAVEATTKYFLTQATAAAMILFASTTNAWISGEW--DMNNLSS---PVATTMII-----TALALKIGLAPMHFWMPEV 118
Cdd:COG1008  156 GERRIYAAIKFFLYTLAGSLLMLVAILALYFLAGALtfDIAELAAaplPLTAQLLLflaffIAFAVKVPMFPFHTWLPDA 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 119 LQ-----GMDLLTGLILstwqKLAPLALI-------IQTAQAVDPLLLTsLGLMSTRAGGGGGLNQTQLRKILAYSSIAH 186
Cdd:COG1008  236 HVeaptaGSVLLAGVLL----KMGGYGLLrfalplfPEASAYFAPLLAA-LGVIGIIYGALVALAQTDLKRLIAYSSVSH 310


                 ....*.
gi 223951272 187 MGWMVV 192
Cdd:COG1008  311 MGFVLL 316
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 101-188 6.41e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 41.58  E-value: 6.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 101 ALALKIGLAPMHFWMPEV-----LQGMDLLTGLILstwqKLA-------PLALIIQTAQAVDPLLLTsLGLMSTRAGGGG 168
Cdd:MTH00217 215 SLAIKIPKIPFHIWLPQAhveapVAGSVILAGVLL----KLGgygfirfSWPLLPEASEYFSPLIQT-LSLLAIIYGSLT 289

                         90       100
                 ....*....|....*....|
gi 223951272 169 GLNQTQLRKILAYSSIAHMG 188
Cdd:MTH00217 290 TCRQVDLKRIIAYSSVAHMG 309
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 4-192 1.02e-03

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 40.69  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272    4 YVLMVLLSSLGLGTtltFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWISGE 83
Cdd:TIGR01972 109 YALLLLLEAGVIGV---FLALDLFLFYVFWEAMLIPMYLLIGVWGGPNRIYAAMKFFLYTLAGSLLMLLAILGLYFLGGG 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   84 W----DMNNLSSPVATTMII-----TALALKIGLAPMHFWMPEV-----LQGMDLLTGLILstwqKLAPLALII------ 143
Cdd:TIGR01972 186 TfdllELLNLPLPFGVQTWLflaffIAFAVKVPLFPLHTWLPDAhveapTAGSVILAGVLL----KMGTYGFLRfnlplf 261

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 223951272  144 -QTAQAVDPLLLtSLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMVV 192
Cdd:TIGR01972 262 pDASLYFAPVLA-ALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLL 310
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
 17-192 1.25e-03

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 40.51  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  17 TTLTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATA------AAMILFASTTNAWISGEWDMNNLS 90
Cdd:PRK08676 115 ITFAFFSDNLALFWIFAELTTVFSAMLIAILSARENIDAALKYIFIASTAmifafiGLIFLFSLTRQALGTGTLNWTELA 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  91 SPV----------ATTMIITALALKIGLAPMHFWMPEVLQGMD-----LLTGLILSTWQ----KLAPLALIIQTAQAVDP 151
Cdd:PRK08676 195 AHAsllspsvlgaSFLFIFIGFLAKSGLVPFHTWLPAAYAKAPsvvsaLLSGTVLNIGIygilRLSALLRQSGAAEQFSN 274

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 223951272 152 LLLtSLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMVV 192
Cdd:PRK08676 275 VLI-GLGIFSIAVAAFSMLSQRNLKKLIAFSSIEHMGLMLL 314
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 98-194 1.86e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 39.90  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  98 IITALALKIGLAPMHFWMPEV-----LQGMDLLTGLILstwqKLAPLALIIQT-------AQAVDPLLLtSLGLMSTRAG 165
Cdd:MTH00226 236 IFLAMAVKIPIFPFHIWLPKAhveapVAGSVLLAGILL----KLGGYGLVRLSwpilplgAQNLAPAVI-AMGIVGIVYG 310

                         90       100
                 ....*....|....*....|....*....
gi 223951272 166 GGGGLNQTQLRKILAYSSIAHMGWMVVIL 194
Cdd:MTH00226 311 SFATCRQIDVKRLVAYSSVAHMGLVSITL 339
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 19-192 2.49e-03

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 39.53  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  19 LTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFL------TQATAAAMILFASTTNAWISGEWDM---NNL 89
Cdd:PRK06458 123 LALTSNNLGLMWVAIEATTLSSALLVGIYRTRASLEAAWKYIIicsvgvAFALFGTILVYANAATVMGDGEMAIlwtELL 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  90 SSPVATTMIITALAL---------KIGLAPMHFWMPevlqgmD-----------LLTGLILstwqKLAPLALI---IQTA 146
Cdd:PRK06458 203 KHASLLDPTLMKLAFvflligfgtKVGLFPMHAWLP------DahseapspvsaLLSGVLL----NVALYAVLryyILID 272

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 223951272 147 QAVDPLLLTSL----GLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMVV 192
Cdd:PRK06458 273 AAIGSDFPGRLllifGLLSVLVAAFFLLRQRDIKRLFAYSSIEHMGLIAF 322
ND5 MTH00032
NADH dehydrogenase subunit 5; Provisional
 111-194 3.73e-03

NADH dehydrogenase subunit 5; Provisional


Pssm-ID: 214407 [Multi-domain]  Cd Length: 669  Bit Score: 39.17  E-value: 3.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 111 MHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVDP-----LLLTSLGLMSTRAGGGGGLNQTQLRKILAYSSIA 185
Cdd:MTH00032 244 LHTWLPDAMEGPTPVSALIHAATMVTAGVFLMIRSFPLFEKapltlLIITIFGALTAFFAATVGLVQNDLKKVIAYSTCS 323


                 ....*....
gi 223951272 186 HMGWMVVIL 194
Cdd:MTH00032 324 QLGYMVLII 332
PRK07234 PRK07234
putative monovalent cation/H+ antiporter subunit D; Reviewed
 6-288 4.91e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235978 [Multi-domain]  Cd Length: 470  Bit Score: 38.78  E-value: 4.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   6 LMVLLSSLGLgttlTFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWISGEWD 85
Cdd:PRK07234 100 LLILHGSVNA----AFVCADLISLYVALEVLSIATFLLVAYPRTDRAIWVGLRYLFYSNVAMLFYLIGAVLVYQANGTFA 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  86 MNNLSS--PVATTMIITALALKIGLAPMHFWMPEVLQGMDLLTGLILSTWQKLAPLALIIQTAQAVDPL--LLTSLGLMS 161
Cdd:PRK07234 176 FSGLATadPEAFALIALGLLVKGGIFVSGLWLPLTHSEAEPPVSALLSGVVVKAGVFPLVRCALDVPGLdlIVRIFGVGT 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272 162 TRAGGGGGLNQTQLRKILAYSSIAHMGWmvvILQYPPQLTLLALgTYIFMTSAAFL---TLKTSSATK-INTLAMVWSNN 237
Cdd:PRK07234 256 ALLGVLFALLEKDLKRMLAFSTISQLGF---ILAAPLVGGLYAL-AHGLVKSTLFLcagALPSRNFTElISQMLGIGKWI 331

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 223951272 238 PTLMTTTAVVLLSLGGlppltGFMPKWLILQELakqdLPITATIMALAALL 288
Cdd:PRK07234 332 PLTMASFSIAGFPLLA-----GFVSKVLTLKNL----LPWQAIALNLAAVG 373
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 4-192 9.70e-03

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 37.70  E-value: 9.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272   4 YVLMVLLSSLGLGTtltFASSHWLLAWMGLEINTLAIVPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWISGE 83
Cdd:PRK12561  90 YFLMLVLYSAQIGV---FLAQDLLLFFLMWELELVPVYLLISIWGGQKRLYAATKFILYTALASIFILVAGLALALSGDT 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223951272  84 --WDMNNLSS---PVATTMI-----ITALALKIGLAPMHFWMPEV-----LQGMDLLTGLILstwqKLAPLALI------ 142
Cdd:PRK12561 167 ftFDLAELGAksyPLALELLlyagfLIAFGVKLPIFPLHTWLPDAhgeasAPVSMILAGVLL----KMGGYALIrfnvqm 242

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 223951272 143 IQTAQAVDPLLLTSLGLMSTRAGGGGGLNQTQLRKILAYSSIAHMGWMVV 192
Cdd:PRK12561 243 LPDAHVYFAPALAILGVVNIIYGALNAFAQDNVKRRLAYSSVSHMGFVLL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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