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Conserved domains on  [gi|223890168|ref|NP_001138799|]
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leucine rich repeat containing protein 20 sclp [Bombyx mori]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-181 6.68e-21

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 6.68e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168  53 QLDLSECQLMQVPDAVYHLmrhTELKSCDLSGNVITKIPPKFAvKFSLITDLNLSNNQMARLPDELCTLACLQRLDISHN 132
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNL---TNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN 215

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 223890168 133 TFVALPHITFQCPSLHTLLAHHNQIieVDVDRLARSQALEYVDLSDNPI 181
Cdd:COG4886  216 QLTDLPEPLANLTNLETLDLSNNQL--TDLPELGNLTNLEELDLSNNQL 262
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-181 6.68e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 6.68e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168  53 QLDLSECQLMQVPDAVYHLmrhTELKSCDLSGNVITKIPPKFAvKFSLITDLNLSNNQMARLPDELCTLACLQRLDISHN 132
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNL---TNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN 215

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 223890168 133 TFVALPHITFQCPSLHTLLAHHNQIieVDVDRLARSQALEYVDLSDNPI 181
Cdd:COG4886  216 QLTDLPEPLANLTNLETLDLSNNQL--TDLPELGNLTNLEELDLSNNQL 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 73-179 3.52e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 3.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168  73 RHTELKSCDLSGNVITKIPPKFAVKFSLITDLNLSNNQMA-RLPDELCTLACLQRLDISHNTFVA-LPHITFQCPSLHTL 150
Cdd:PLN00113 473 GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGqIPASFSEMPVLSQL 552

                         90       100
                 ....*....|....*....|....*....
gi 223890168 151 LAHHNQIIEVDVDRLARSQALEYVDLSDN 179
Cdd:PLN00113 553 DLSQNQLSGEIPKNLGNVESLVQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
75-132 1.45e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 1.45e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 223890168   75 TELKSCDLSGNVITKIPPKFAVKFSLITDLNLSNNQMARL-PDELCTLACLQRLDISHN 132
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 115-181 1.92e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 1.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 223890168 115 PDELCTLA-CLQRLDISHNtfvalpHIT----FQC-PSLHTLLAHHNQI--IEVDVDRLARSQALEYVDLSDNPI 181
Cdd:cd21340  112 PRSLAALSnSLRVLNISGN------NIDslepLAPlRNLEQLDASNNQIsdLEELLDLLSSWPSLRELDLTGNPV 180
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-181 6.68e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 6.68e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168  53 QLDLSECQLMQVPDAVYHLmrhTELKSCDLSGNVITKIPPKFAvKFSLITDLNLSNNQMARLPDELCTLACLQRLDISHN 132
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNL---TNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN 215

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 223890168 133 TFVALPHITFQCPSLHTLLAHHNQIieVDVDRLARSQALEYVDLSDNPI 181
Cdd:COG4886  216 QLTDLPEPLANLTNLETLDLSNNQL--TDLPELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-181 1.32e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 1.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168  52 SQLDLSECQLMQVPDAVYHLmrhTELKSCDLSGNVITKIPPKFAvKFSLITDLNLSNNQMARLPDELCTLACLQRLDISH 131
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANL---TNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 223890168 132 NTFVALPHITFQCPSLHTLLAHHNQIIEVDVDrLARSQALEYVDLSDNPI 181
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-181 4.29e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 4.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168  71 LMRHTELKSCDLSGNvitkippKFAVKFSLITDLNLSNNQMARLPDELCTLACLQRLDISHNTFVALPHITFQCPSLHTL 150
Cdd:COG4886   92 LGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSL 164

                         90       100       110
                 ....*....|....*....|....*....|.
gi 223890168 151 LAHHNQIIEVDVDrLARSQALEYVDLSDNPI 181
Cdd:COG4886  165 DLSNNQLTDLPEE-LGNLTNLKELDLSNNQI 194
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 73-179 3.52e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 3.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168  73 RHTELKSCDLSGNVITKIPPKFAVKFSLITDLNLSNNQMA-RLPDELCTLACLQRLDISHNTFVA-LPHITFQCPSLHTL 150
Cdd:PLN00113 473 GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGqIPASFSEMPVLSQL 552

                         90       100
                 ....*....|....*....|....*....
gi 223890168 151 LAHHNQIIEVDVDRLARSQALEYVDLSDN 179
Cdd:PLN00113 553 DLSQNQLSGEIPKNLGNVESLVQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
75-132 1.45e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 1.45e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 223890168   75 TELKSCDLSGNVITKIPPKFAVKFSLITDLNLSNNQMARL-PDELCTLACLQRLDISHN 132
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
54-184 2.74e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.30  E-value: 2.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168  54 LDLSECQLMQVPDAVyhlmrHTELKSCDLSGNVITKIPPKFAvkfSLITDLNLSNNQMARLPDEL-----------CTLA 122
Cdd:PRK15370 267 LDLFHNKISCLPENL-----PEELRYLSVYDNSIRTLPAHLP---SGITHLNVQSNSLTALPETLppglktleageNALT 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168 123 C--------LQRLDISHNTFVALPHITfqCPSLHTLLAHHN-------------QIIEVDVDRLAR-SQALEYVdLSDNP 180
Cdd:PRK15370 339 SlpaslppeLQVLDVSKNQITVLPETL--PPTITTLDVSRNaltnlpenlpaalQIMQASRNNLVRlPESLPHF-RGEGP 415


                 ....
gi 223890168 181 IPAR 184
Cdd:PRK15370 416 QPTR 419
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-114 7.62e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 7.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223890168  54 LDLSECQLMQVPDavyhLMRHTELKSCDLSGNVITKIPPkfAVKFSLITDLNLSNNQMARL 114
Cdd:COG4886  233 LDLSNNQLTDLPE----LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-181 1.42e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168 100 LITDLNLSNNQMARLPDELCTLACLQRLDISHNTFVA-----------------LPHITFQCPSLHTLLAHHNQIIEVDV 162
Cdd:COG4886   74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSnltnlesldlsgnqltdLPEELANLTNLKELDLSNNQLTDLPE 153

                         90
                 ....*....|....*....
gi 223890168 163 DrLARSQALEYVDLSDNPI 181
Cdd:COG4886  154 P-LGNLTNLKSLDLSNNQL 171
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-203 1.44e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168  72 MRHTELKSCDLSGnvitKIPPKFaVKFSLITDLNLSNNQM-ARLPDELCTLACLQRLDISHNTFVA-LPHiTFQCPSLHT 149
Cdd:PLN00113 406 LRRVRLQDNSFSG----ELPSEF-TKLPLVYFLDISNNNLqGRINSRKWDMPSLQMLSLARNKFFGgLPD-SFGSKRLEN 479

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 223890168 150 LLAHHNQIIEVDVDRLARSQALEYVDLSDNPIPARTHDDLKQLSR-PSVTLSDRQ 203
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKlVSLDLSHNQ 534
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-132 1.83e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168  53 QLDLSECQLMQ-VPDAvyhLMRHTELKSCDLSGNVITKIPPKFAVKFSLITDLNLSNNQMA-RLPDELCTLACLQRLDIS 130
Cdd:PLN00113 479 NLDLSRNQFSGaVPRK---LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLS 555


                 ..
gi 223890168 131 HN 132
Cdd:PLN00113 556 QN 557
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 115-181 1.92e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 1.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 223890168 115 PDELCTLA-CLQRLDISHNtfvalpHIT----FQC-PSLHTLLAHHNQI--IEVDVDRLARSQALEYVDLSDNPI 181
Cdd:cd21340  112 PRSLAALSnSLRVLNISGN------NIDslepLAPlRNLEQLDASNNQIsdLEELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
124-181 2.40e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 2.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 223890168  124 LQRLDISHNTFVALPHITFQ-CPSLHTLLAHHNQIIEVDVDRLARSQALEYVDLSDNPI 181
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 49-192 7.46e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 36.69  E-value: 7.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168  49 QENSQ---LDLSECQLmQVPDAVY---HLMRHTELKSCDLSGNVIT-----KIPPKFAvKFSLITDLNLSNNQ-----MA 112
Cdd:COG5238  261 KNNTTvetLYLSGNQI-GAEGAIAlakALQGNTTLTSLDLSVNRIGdegaiALAEGLQ-GNKTLHTLNLAYNGigaqgAI 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890168 113 RLPDELCTLACLQRLDISHNTF-----VALPHITFQCPSLHTLLAHHNQIIEVDVDRLARS---QALEYVDLSDNPIPAR 184
Cdd:COG5238  339 ALAKALQENTTLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAlqtNRLHTLILDGNLIGAE 418


                 ....*...
gi 223890168 185 THDDLKQL 192
Cdd:COG5238  419 AQQRLEQL 426
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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